Updated on 2025/02/26

Information

 

写真a

 
SOMAMOTO TOMONORI
 
Organization
Faculty of Agriculture Department of Bioscience and Biotechnology Associate Professor
School of Agriculture Department of Bioresource and Bioenvironment（Concurrent）
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioscience and Biotechnology（Concurrent）
School of Education （Concurrent）
Title
Associate Professor
Contact information
メールアドレス
Tel
0928024792
Profile
ある病原体に感染、発病し治癒するとその病気には二度と罹らないという現象が魚でも存在する。これは哺乳類と同様に一度生体内に侵入した病原体を記憶するという獲得免疫系が魚類でも備わっていることを示している。この獲得免疫系の主役はT細胞であるが、魚類のT細胞機能に関する知見は乏しい。そのようなか、クローンギンブナとそれら由来の細胞株を用いることにより、哺乳類の細胞傷害性T細胞の機能に匹敵する能力が魚の白血球にも備わっていることを明らかにした。今後は、魚の獲得免疫機構がどこまで哺乳類に匹敵するものなのかを明らかにし、養殖魚の感染症のワクチン開発への貢献を目指した研究を行う。
Homepage
External link

Degree

  • PhD

Research History

  • 日本学術振興会特別研究員(PD) 受け入れ先機関名；独立行政法人水産総合研究センター養殖研究所(2003年4月から2005年1月まで)   

    日本学術振興会特別研究員(PD) 受け入れ先機関名；独立行政法人水産総合研究センター養殖研究所(2003年4月から2005年1月まで)

Research Interests・Research Keywords

  • Research theme： Development of oral vaccination for fish using siik protein

    Keyword： 経口投与　ワクチン　魚類　シルクタンパク質

    Research period： 2023.10 - Present

  • Research theme： Prevention of fish disease using affinity silk

    Keyword： affinity silk, fish disease,　prophylaxis

    Research period： 2016.4 - Present

  • Research theme： The study of cell-mediated immunity in fish

    Keyword： cell-mediated immunity, virus, ginbuna crucian carp

    Research period： 2003.4 - Present

  • Research theme： Immune systems of rag-1-deficient zebrafish against bacterial and viral infection.

    Keyword： zebrafish RAG-1-deficient immune system infection

    Research period： 2011.4 - 2014.3

  • Research theme： Development of prophylaxis strategy against infectious disease in koi carp employing hen egg antibody (IgY)

    Keyword： IgY, prophylaxis, koi caro.

    Research period： 2008.5 - 2015.3

Awards

  • 日本魚病学会研究奨励賞

    2023.3   日本魚病学会   魚類の細胞傷害T細胞のウイルスや寄生虫に対する細胞性免疫応答に関する一連の研究が、魚病学や魚類免疫学分野において顕著な研究成果であると認められたことにより、「魚類の病原体に対する細胞性免疫に関する研究」という研究題目で受賞した。本賞は、学術上の貢献著しく、将来一層の発展が期待される業績を挙げた個人または、研究集団に授与する章であり、日本魚病学会の会員の名から毎年0～2名選出される。日本魚病学会は、病原体の分類や生態、病理、治療、予防など、魚介類の疾病に関する広範囲な分野について、研究の進歩と知識の普及を図ることを目的に1966年に設立さた、57年の歴史をもつ学会であり、2023年現在400名以上の会員を有する。

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    魚類の細胞傷害T細胞のウイルスや寄生虫に対する細胞性免疫応答に関する一連の研究が、魚病学や魚類免疫学分野において顕著な研究成果であると認められたことにより、「魚類の病原体に対する細胞性免疫に関する研究」という研究題目で受賞した。

Papers

  • Expression of two CD83 homologs in macrophage subpopulations isolated from the brain and kidney of ginbuna crucian carp Reviewed International journal

    Tran TT, Prakash H, Nagasawa T, Nakao M, Somamoto T.

    Fish and Shellfish Immunology   156   110038   2025.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi.org/10.1016/j.fsi.2024.110038

    Repository Public URL： https://hdl.handle.net/2324/7339180

  • Characterization of CD83 homologs differently expressed during monocytes differentiation in ginbuna crucian carp, <i>Carassius auratus langsdorfii</i>. Reviewed International journal

    Tran, TT; Prakash, H; Nagasawa, T; Nakao, M; Somamoto, T

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   159   105212   2024.10   （ ISSN:0145-305X eISSN:1879-0089 ）

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Developmental and Comparative Immunology  

    CD83 is a costimulatory molecule of antigen-presenting cells (APCs) that plays an important role in eliciting adaptive responses. It is also a well-known surface protein on mature dendritic cells (DCs). Furthermore, monocytes have been reported to differentiate into macrophages and monocyte-derived dendritic cells, which play an important role in innate immunity. CD83 expression affects the activation and maturation of DCs and stimulates cell-mediated immune responses. This study aims to reveal the CD83 expression during monocyte differentiation in teleosts, and the CD83 homologs evolutionary relationship. This study found two distinct CD83 homologs (GbCD83 and GbCD83-L) in ginbuna crucian carp (Gb) and investigated the evolutionary relationship among GbCD83 homologs and other vertebrates and the gene and protein expression levels of the homologs during 4 days of monocyte culture. The phylogenetic tree showed that the two GbCD83 homologs are classified into two distinct branches. Interestingly, only ostariophysians (Gb, common carp, rohu, fathead minnow and channel catfish), but not neoteleosts, mammals, and others, have two CD83 homologs. Morphological observation and colony-stimulating factor-1 receptor (CSF-1R), CD83, CD80/86, and CCR7 gene expressions illustrated that there is a differentiation of monocytes isolated from peripheral blood leukocytes after 4 days. Specifically, gene expression and immunocytochemistry revealed that GbCD83 is mainly expressed on monocytes at the early stage of cell culture, whereas GbCD83-L is expressed in the latter stage. These findings provided the first evidence of differential expression of CD83 homologs during monocytes differentiation in teleost.

    DOI： 10.1016/j.dci.2024.105212

    Web of Science

    Scopus

    PubMed

  • Non-specific cytotoxic cell receptor protein-1 (NCCRP-1) is involved in anti-parasite innate CD8+ T cell-mediated cytotoxicity in ginbuna crucian carp Reviewed International journal

    Sukeda M, Prakash H, Nagasawa T, Nakao M, Somamoto T.

    Fish Shellfish Immunol   139   108904.   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi: 10.1016/j.fsi.2023.108904.

    Repository Public URL： https://hdl.handle.net/2324/6795485

  • Development of a filter device for the prevention of aquatic bacterial disease using a single-chain variable fragment (scFv)-conjugated affinity silk. Reviewed International journal

    Prakash H, Sato M, Kojima K, Sato A, Maruyama S, Nagasawa T, Nakao M, Somamoto T

    Scientific Reports   12   9475   2022.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi.org/10.1038/s41598-022-13408-6

  • Local immune responses to two stages of Ichthyophthirius multifiliis in ginbuna crucian carp. Reviewed International journal

    Shiota K, Sukeda M, Prakasha H, Kondo M, Nakanishi T, Nagasawa T, Nakao M, Somamoto T.

    Fish and Shellfish Immunology   118   19 - 24   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi.org/10.1016/j.fsi.2021.08.013

    Repository Public URL： http://hdl.handle.net/2324/4495875

  • Innate cell-mediated cytotoxicity of CD8+ T cells against the protozoan parasite Ichthyophthirius multifiliis in the ginbuna crucian carp, Carassius auratus langsdorfii. Reviewed International journal

    Sukeda M, Shiota K, Kondo M, Nagasawa T, Nakao M, Somamoto T.

    Developmental and Comparative Immunology   115   103886.   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1016/j.dci.2020.103886

    Repository Public URL： http://hdl.handle.net/2324/4113184

  • Generation of virus-specific CD8+ T cells by vaccination with inactivated virus in the intestine of ginbuna crucian carp. Reviewed International journal

    Seisuke Tajimi, Masakazu Kondo, Teruyuki Nakanishi, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    Developmental and comparative immunology   93   37 - 44   2019.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2018.12.009

    Repository Public URL： http://hdl.handle.net/2324/2552964

  • Development of anti-atypical aeromonas salmonicida monoclonal antibodies for diagnosis of new ulcer disease in koi carp Reviewed

    Tomonori Somamoto, Shinpei Maruyama, Takahiro Nagasawa, Miki Nakao, Atsushi Sato, Hajime Hatta, Mitsuru Sato, Yukie Murakami-Yamaguchi, Kumiko Kizu-Mori, Yuki Hirakawa, Hiroshi Narita

    Fish Pathology   53 ( 1 )   36 - 39   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3147/jsfp.53.36

  • Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts. Reviewed International journal

    Yumie Tokunaga, Masamichi Shirouzu, Ryota Sugahara, Yasutoshi Yoshiura, Ikunari Kiryu, Mitsuru Ototake, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    Scientific reports   7 ( 1 )   7536 - 7536   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-08000-2

  • Functional analysis of membrane-bound complement regulatory protein on T-cell immune response in ginbuna crucian carp Reviewed International journal

    Indriyani Nur, Nevien K. Abdelkhalek, Shiori Motobe, Ryota Nakamura, Masakazu Tsujikura, Tomonori Somamoto, Miki Nakao

    Molecular Immunology   70   1 - 7   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.molimm.2015.11.010

  • Local and systemic adaptive immune responses toward viral infection via gills in ginbuna crucian carp. Reviewed International journal

    Tomonori Somamoto, Yuhei Miura, Teruyuki Nakanishi, Miki Nakao

    Developmental and comparative immunology   52 ( 1 )   81 - 7   2015.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2015.04.016

  • Ulcer disease prophylaxis in koi carp by bath immersion with chicken egg yolk containing anti-Aeromonas salmonicida IgY Reviewed International journal

    Hongjian Gan, Haiwen He, Atsushi Sato, Hajime Hatta, Miki Nakao, Tomonori Somamoto

    RESEARCH IN VETERINARY SCIENCE   99   82 - 86   2015.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.rvsc.2015.01.016

  • Phagocytosis by thrombocytes is a conserved innate immune mechanism in lower vertebrates. Reviewed International journal

    Nagasawa T, Nakayasu C, Rieger AM, Barreda DR, Somamoto T, Nakao M

    Frontiers in Immunology   5   445   2014.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi: 10.3389/fimmu.2014.00445

  • Helper function of CD4⁺ lymphocytes in antiviral immunity in ginbuna crucian carp, Carassius auratus langsdorfii. Reviewed International journal

    Tomonori Somamoto, Masakazu Kondo, Teruyuki Nakanishi, Miki Nakao

    Developmental and comparative immunology   44 ( 1 )   111 - 5   2014.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2013.12.008

  • Molecular characterization and expression analysis of three membrane-bound complement regulatory protein isoforms in the ginbuna crucian carp Carassius auratus langsdorfii Reviewed International journal

    Indriyani Nur, Hikari Harada, Masakazu Tsujikura, Tomonori Somamoto, Miki Nakao

    Fish & shellfish immunology   35 ( 4 )   1333 - 1337   2013.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.fsi.2013.08.002

  • Identification of anti-viral cytotoxic effector cells in the ginbuna crucian carp, Carassius auratus langsdorfii. Reviewed International journal

    Tomonori Somamoto, Teruyuki Nakanishi, Miki Nakao

    Developmental and comparative immunology   39 ( 4 )   370 - 7   2013.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2012.11.001

  • Diversity of CD2 subfamily receptors in cyprinid fishes. Reviewed International journal

    Sameshima S, Nakao M, Somamoto T.

    Result Immunol   2   2012.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Molecular characterization of MHC class I and beta-2 microglobulin in a clonal strain of ginbuna crucian carp, Carassius auratus langsdorfii. Reviewed International journal

    Shinji Urabe, Tomonori Somamoto, Shiro Sameshima, Yoko Unoki-Kato, Teruyuki Nakanishi, Miki Nakao

    Fish & shellfish immunology   31 ( 3 )   469 - 74   2011.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.fsi.2011.06.004

  • In vitro generation of viral-antigen dependent cytotoxic T-cells from ginbuna crucian carp, Carassius auratus langsdorfii. Reviewed International journal

    Tomonori Somamoto, Nobuaki Okamoto, Teruyuki Nakanishi, Mitsuru Ototake, Miki Nakao

    Virology   389 ( 1-2 )   26 - 33   2009.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.virol.2009.04.008

  • Expression profiles of TCRβ and CD8α mRNA correlate with virus-specific cell-mediated cytotoxic activity in ginbuna crucian carp Reviewed International journal

    Tomonori Somamoto, Yasutoshi Yoshiura, Atsushi Sato, Miki Nakao, Teruyuki Nakanishi, Nobuaki Okamoto, Mitsuru Ototake

    Virology   2006.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Identification and characterization of a second CD4-like gene in teleost fish. Reviewed International journal

    J.M. Dijkstra, T. Somamoto, L. Moore, I. Hordvik, M. Ototake, and U. Fischer.

    Molecular Immunology   2006.2

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  • Molecular cloning and characterization of two types of CD8α from ginbuna crucian carp, Carassius auratus langsdorfii. Reviewed International journal

    Tomonori Somamoto, Yasutoshi Yoshiura, Teruyuki Nakanishi, Mitsuru Ototake.

    Developmental and Comparative Immunology   2005.7

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Specific cytotoxic activity generated by mixed leucocyte culture in ginbuna crucian carp. Reviewed International journal

    Tomonori Somamoto, Atsushi Sato, Teruyuki Nakanishi, Mitsuru Ototake, and Nobuaki Okamoto.

    Fish & Shellfish Immunology   2004.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Role of specific cell-mediated cytotoxicity in protecting fish from viral infections. Reviewed International journal

    Tomonori Somamoto, Teruyuki Nakanishi, and Nobuaki Okamoto.

    Virology   2002.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Specific cytotoxic cells of ginbuna crucian carp are responsible for in vivo clearance of carp haematopoietic necrosis virus (CHNV). Reviewed

    Tomonori Somamoto, Teruyuki Nakanishi, and Nobuaki Okamoto.

    Fisheries Science   2002.1

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    Language：English   Publishing type：Research paper (other academic)  

  • Specific cell-mediated cytotoxicity against a virus-infected syngeneic cell line in isogeneic ginbuna crucian carp. Reviewed International journal

    Tomonori Somamoto, Teruyuki Nakanishi, and Nobuaki Okamoto.

    Developmental and Comparative Immunology   2000.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp, Cyprinus carpio. Reviewed International journal

    Nehlah R, Yamamoto A, Nagasawa A, Somamoto T and Miki Nakao.

    Journal of Marine Science and Engineering   11   707   2023.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.3390/jmse11040707

  • Homeostatic Functions of Tecrem, a CD46-Like Regulatory Protein of Complement Activation, on Epithelial Cells in Carp Fish. Reviewed International journal

    Harsha Prakash, Shiori Motobe, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    Journal of Marine Science and Engineering   9 ( 7 )   687   2021.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.3390/jmse9070687

  • Expression profile of kalliklectin, a soluble-type mannose receptor, during embryogenesis and early larval development in fugu (Takifugu rubripes). Reviewed International journal

    Matsui S., Yoshikawa S., Suzuki S., Somamoto T., Yamamoto A., Nakamura O., Tsutsuia S.

    Molecular Immunology   126   129 - 135   2020.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.molimm.2020.07.022.

  • A CD46-like Molecule Functional in Teleost Fish Represents an Ancestral Form of Membrane-Bound Regulators of Complement Activation Reviewed International journal

    Masakazu Tsujikura, Takahiro Nagasawa, Satoko Ichiki, Ryota Nakamura, Tomonori Somamoto, Miki Nakao

    JOURNAL OF IMMUNOLOGY   194 ( 1 )   262 - 272   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.1303179

  • Purification and functional characterization of complement C3 and a novel zymosan-binding protein in tilapia serum Reviewed

    Soha G. R. Abdel-Salam, Masakazu Tsujikura, Masakazu Kondo, Tomonori Somamoto, Miki Nakao

    FISHERIES SCIENCE   80 ( 2 )   301 - 310   2014.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Zymosan, a yeast cell wall preparation that binds activated forms of complement C3, is a useful model target to activate the complement system. In our trial to analyze C3 diversity in Nile tilapia at the protein level using zymosan, we found that a novel 240-kDa serum protein (ZBP-240) also bound to zymosan in addition to C3-derived fragments. In the present study, we aimed to characterize tilapia C3 and ZBP-240, focusing on their immune-related functions. Four distinct C3 isoforms were purified from tilapia serum and shown to possess an intrachain thioester bond. ZBP-240 was also isolated from tilapia serum and examined for its binding properties to various microbial targets. As a result, ZBP-240 showed a wide spectrum of binding to Gram-positive and Gram-negative bacteria and yeasts. Amino acid sequence analysis of CNBr fragments of ZBP-240 suggested that this is a novel protein with no homologous sequence in protein databases. It was also suggested that the binding of ZBP-240 to microbes largely depends on hydrophobic interactions in a divalent-cation-independent manner, and that there may be a divalent-cation-dependent factor that enhances the binding of ZBP-240 in tilapia serum. Interestingly, ZBP-240 showed opsonic activity for tilapia kidney phagocytes at a level comparable to that of C3, implying that ZBP-240 is a novel teleost opsonic serum protein.

    DOI： 10.1007/s12562-014-0700-7

    Repository Public URL： http://hdl.handle.net/2324/4776908

  • Identification of Immune Relevant Genes Using Expressed Sequence Tags (ESTs) in Common carp (Cyprinus carpio) Gills and Intestine Reviewed

    Nevien K. Abdelkhalek, Asuka Komiya, Yoko Kato-Unoki, Tomonori Somamoto, Mild Nakao

    JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY   59 ( 1 )   109 - 116   2014.2

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    Identification of immune related molecules that function in fish organs is important for better understanding of the host defense mechanisms in fish. Expressed sequence tags (ESTs) represent the expressed portion of a genome, so they have proven to be useful tool for gene identification and confirmation of gene predictions. In the present study, a transcriptome analysis of carp gill and intestine EST libraries have been done as an attempt to identify the immune relevant genes expressed in those organs. A total of 2148 EST clones were generated from the two libraries: 1099 clones from gill library in which 632 clones were matched with functional proteins and 1049 clones from intestine library in which 559 clones were matched with functional proteins. The results of gill EST library has more frequency of innate immune molecules containing MHC class I and MEG class II, which showed 18.3&#37; of the immune molecules than those in intestine library which represents 10.8&#37; only. The gill library also showed higher frequency of the cytokines and chemokine molecules and/or their receptors compared to the intestine library.

  • The binding spectra of carp C3 isotypes against natural targets independent of the binding specificity of their thioester. Reviewed International journal

    Satoko Ichiki, Yoko Kato-Unoki, Tomonori Somamoto, Miki Nakao

    Developmental and comparative immunology   38 ( 1 )   10 - 6   2012.9

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    The central component of complement, C3, plays a versatile role in innate immune defense of vertebrates and some invertebrates. A notable molecular characteristic of this component is an intra-chain thioester site that enables C3 to bind covalently to its target. It has been reported that the binding preference of the thioester to hydroxyl or amino groups is primarily defined by presence or absence of the catalytic histidine residue at position 1126 in human C3. In teleosts, a unique C3 (non-His type) has been found, in addition to the common His type C3. These distinct C3 isoforms may provide diversity in the target-binding attributable to the different binding specificities of their thioesters. In the present study, we examine the hypothesized correlation of the catalytic histidine with the binding spectra of two major C3 isotypes of carp towards various model and natural targets. The results reveal that non-His type C3, rather than His type C3, has a wider range of binding spectrum, despite the binding specificity of its thioester being limited to amino groups. It is therefore hypothesized that the binding spectra of C3 isotypes are not defined by the binding specificity of the thioester but is more affected by differences in microbe-associated molecular patterns that activate complement. Overall, the present data imply that non-His type C3 plays a significant role against bacterial infections in the fish defense system.

    DOI： 10.1016/j.dci.2012.03.004

  • Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish. Reviewed International journal

    Hideaki Toda, Yasutaka Saito, Takuhito Koike, Fumio Takizawa, Kyosuke Araki, Takeshi Yabu, Tomonori Somamoto, Hiroaki Suetake, Yuzuru Suzuki, Mitsuru Ototake, Tadaaki Moritomo, Teruyuki Nakanishi

    Developmental and comparative immunology   35 ( 6 )   650 - 60   2011.6

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    The presence of helper and cytotoxic T cells in fish has been suggested, although T cell subsets have yet to be identified at the cellular level. In order to investigate the functions of CD4 and CD8α positive T cells we attempted to produce and characterize monoclonal antibodies (mAbs) against teleost CD4 and CD8α. Here we report the successful production of mAbs against CD4 and CD8α in clonal ginbuna crucian carp Carassius auratus langsdorfii and the function of CD4 positive T cells. In this study we demonstrate the presence of teleost CD4- and CD8α-positive T cell subsets with morphology, tissue distribution and gene expression similar to those of mammalian CD4- and CD8-positive T lymphocytes. Using mAbs we found that CD4/CD8 double positive T cells are only present in the thymus, suggesting that it is the site of T cell development. We further demonstrated in vitro proliferation of CD4 positive T cells by allogeneic combination of mixed leukocyte culture and antigen-specific proliferation of CD4 positive T cells after in vitro sensitization with OVA. In our previous study we showed that CD8α-positive lymphocytes are the primary cell type showing specific cytotoxicity against allogeneic targets. Collectively, these findings suggest that CD4 and CD8α positive T cells in ginbuna are equivalent to helper and cytotoxic T lymphocytes (CTL) in mammals, respectively. This is the first report to show the characteristics and functions of CD4 positive T cells in fish and these findings shed light into the evolutionary origins and primordial functions of helper T cells.

    DOI： 10.1016/j.dci.2011.01.013

  • Molecular evidence for the existence of two distinct IL-8 lineages of teleost CXC-chemokines Reviewed International journal

    Nevien K. Abdelkhalek, Asuka Komiya, Yoko Kato-Unoki, Tomonori Somamoto, Miki Nakao

    Fish & shellfish immunology   27 ( 6 )   763 - 767   2009.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.fsi.2009.08.004

  • Identification of cDNA Sequences Encoding the Complement Components of Zebrafish (Danio rerio) Reviewed

    Vo Kha Tam, Masakazu Tsujikura, Tomonori Somamoto, Miki Nakao

    JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY   54 ( 2 )   373 - 387   2009.10

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    Zebrafish can be utilized for immunological research as a fish model that allows gene targeting, but lacks enough molecular and sequence information on the complement system, a humoral innate immune factor. The present study aimed at identification of all the major complement components at the molecular level with phylogenetic evidence. Complementary DNA sequences encoding C1q, C1r/s, C2 (B/C2-B), C3, C4, C5, C6, C7, C8, C9, factor B (B/C2-A), the mannose-binding lectin (MBL), two MBL-associated serine proteases, properdin, and factor I were identified by cloning from the hepatopancreas and by database mining. As reported for carp and trout, the presence of two distinct isotypes were confirmed for C3, C4, and C7 also in zebrafish, indicating the ancient evolutionary origin of their diversifications in the vertebrate lineage.

  • Expression Responses of the Complement Components in Zebrafish Organs after Stimulation with Poly I:C, Mimicry of Viral Infection Reviewed

    Vo Kha Tam, Masakazu Tsujikura, Tomonori Somamoto, Miki Nakao

    JOURNAL OF THE FACULTY OF AGRICULTURE KYUSHU UNIVERSITY   54 ( 2 )   389 - 395   2009.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    Defensive roles of the complement system in fish are largely unknown, although expressions of several complement components have been examined in some teleost species upon bacterial and parasitic infections. To infer possible anti-virus defensive roles of the complement system in teleost, zebrafish were simulated by intraperitoneal injection of poly 1: C, a double strand RNA analogue, to mimic viral infection, and expression of 24 complement components and their subunits in the gill, brain, kidney, gut, hepatopancreas, gonad, heart, spleen, and skin were analyzed by reverse-transcription PCR. In normal (unstimulated) fish, the hepatopancreas showed highest expression of most genes tested, and considerable extra hepatic expression was also observed for many complement components. Upon stimulation, the hepatopancreas showed decreased expression of CD11/CD18, B/C2-A3, MASP3, and properdin, while marked up-regulation of several complement component genes was observed in the gill, suggesting an important but unknown role of the gill in host, defense against viral infection.

  • Molecular cloning of CD4 from ginbuna crucian carp Carassius auratus langsdorfii Reviewed

    Seiko Nonaka, Tomonori Somamoto, Yoko Kato-Unoki, Mitsuru Ototake, Teruyuki Nakanishi, Miki Nakao

    FISHERIES SCIENCE   74 ( 2 )   341 - 346   2008.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    The clonal triploid ginbuna crucian carp Carassius auratus langsdorfii, a naturally occurring gynogenetic fish, is a useful model for studying T-cell-mediated immunity. CD4, a T-cell receptor (TCR) coreceptor, is a membrane-bound glycoprotein found on helper T-cells, and assists in the binding of major histocompatibility complexes. In the present study, full-length cDNAs encoding the CD4 molecule from the S3n strain of ginbuna crucian carp were cloned and characterized. 5'-rapid amplification of cDNA ends (RACE) and 3'-RACE yielded two distinct cDNA clones of CD4 homolog from the ginbuna, and these sequences share 95&#37; identity at the amino acid level. These ginbuna CD4 molecules consisted of a signal peptide, immunoglobulin superfamily (IgSf) like domains, a transmembrane domain, and a cytoplasmic domain similar to other known CD4. A tyrosine protein kinase p56(lck) binding motif is conserved in the cytoplasmic tail of ginbuna CD4. Phylogenetic tree analysis indicated that ginbuna CD4 sequences are closely related to CD4L-1 from other fish species. Expression of ginbuna CD4 mRNA was detected in the gill, thymus, head kidney, trunk kidney and peripheral blood leukocytes, indicating that its expression pattern is similar to that of ginbuna TCR beta mRNA. The results suggest that ginbuna CD4 sequences are useful as molecular probes for helper T-cells.

    DOI： 10.1111/j.1444-2906.2008.01530.x

  • Genomic organization and expression of CD8α and CD8β genes in fugu Takifugu rubripes Reviewed International journal

    Suetake H, Araki K, Akatsu K, Somamoto T, Dijkstra J. M, Yoshiura Y, Kikuchi K, Suzuki Y

    Fish Shellfish Immunol   23 ( 5 )   1107 - 18   2007.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    Genomic organization and expression of CD8alpha and CD8beta genes in fugu Takifugu rubripes.
    We have cloned cDNAs encoding the alpha and beta chains of CD8 from the tiger pufferfish (fugu), Takifugu rubripes. The cDNA sequences encode a putative leader peptide, extracellular immunoglobulin variable region-like domain, stalk region, transmembrane region, and cytoplasmic tail. A protein tyrosine kinase p56lck binding motif was not found in the putative fugu CD8alpha cytoplasmic tail. O-linked glycosylation sites were found in the stalk of both CD8 chains, suggesting possible stalk formation. Phylogenetic analysis showed that fugu CD8alpha and CD8beta chains cluster with other vertebrate CD8alpha and CD8beta chains, respectively. The fugu CD8 genes comprise six exons separated by five introns. The genes are tandemly aligned 3.6 kb apart and are in the same transcription orientation. Quantitative RT-PCR analysis demonstrated that fugu CD8 is expressed predominantly in lymphoid tissues. In situ hybridization showed that fugu CD8 genes are expressed in thymocytes and lymphocytes within lymphoid organs. Molecular characterization of CD8 in fish provides the basis for development of specific antibodies to identify T-cell subsets, as well as potentially important insights into the evolution of CD8 and the adaptive immunity.

    DOI： 10.1016/j.fsi.2007.05.005

  • Lectin pathway of bony fish complement:Identification of two homologues of the　mannose-binding lectin associated with MASP2 in the common carp (Cyprinus　carpio) Reviewed International journal

    Miki Nakao, Takayuki Kajiya, Yuho Sato, Tomonori Somamoto, Yoko Unoki-Kato, Misao Matsushita, Munehiro Nakata, Teizo Fujita and Tomoki Yano.

    Journal of Immunology   2006.10

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Characterisation of salmon and trout CD8alpha and CD8beta. Reviewed International journal

    L J Moore, T Somamoto, K K Lie, J M Dijkstra, I Hordvik

    Molecular immunology   42 ( 10 )   1225 - 34   2005.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    The genes and corresponding cDNAs of both alpha and beta chains of the Atlantic salmon (Salmo salar) CD8 molecule have been sequenced and characterized. In addition, the cDNAs for alpha and beta chains of brown trout (Salmo trutta) and for the beta chain in rainbow trout (Oncorhynchus mykiss) have been sequenced. The cDNAs code for signal sequences which are preceded by short 5' UTRs. These are followed by typical immunoglobulin superfamily variable sequences all of which contain two conserved cysteines for the intra-chain disulphide bond. The hinge regions display conserved cysteines for dimerisation and several O-glycosylation motifs for each predicted protein. The domain sharing the highest sequence identity with mammals is the single pass transmembrane domain for all sequences. In salmon, each domain is predominantly coded for by a single exon except the cytoplasmic/3' UTR domains, which are coded for by 3 and 2 exons for the alpha and beta genes, respectively. In the alpha gene, the second cytoplasmic exon may be spliced out to form an alternative shorter transcript which if expressed would exhibit a truncated cytoplasmic tail. A splice variant found for the salmon beta gene introduces a stop codon after only 40 amino acids. Overall amino acid identities between salmonid sequences were higher than 90%, whereas they shared only 15-20% identity with species such as, chicken and human. Analysis of the expression patterns of the two salmon genes using quantitative RT-PCR shows a very high expression in the thymus. This is mirrored by the expression of the TCRalpha gene, which is known to be co-expressed with CD8 on mammalian T cells. This is the first report of a sequence for CD8beta in a teleost and together with the CD8alpha sequence, it encodes the ortholog of the CD8 co-receptor molecule on mammalian T cells.

  • Differential spontaneous killing of human and murine tumor cell lines by leucocyte subpopulations from carp peripheral blood leucocytes. Reviewed International journal

    Chihaya Nakayasu, Tomonori Somamoto, Satoshi Hasegawa, Tomoyasu Yoshitomi, and Nobuaki Okamoto.

    Fish & Shellfish Immunology   2005.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Characterisation of salmon and trout CD8α and CD8β. Reviewed International journal

    L.J. Moore, T. Somamoto, K.K. Lie, J.M. Dijkstra and I. Hordvik.

    Molecular Immunology   2005.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Systemic priming of alloreactive cytotoxic cells in carp,　following anal administration of allogeneic cell antigens. Reviewed International journal

    Atsushi Sato, Tomonori Somamoto, Hiroyuki Yokooka, Nobuaki Okamoto.

    Fish & Shellfish Immunology   2005.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Non-specific immune response of rainbow trout (Oncorhynchus mykiss Walbaum) in relation to different status of vitamin E and highly unsaturated fatty acids. Reviewed International journal

    J. Puangkae, V. Kiron, T. Somamoto, N. Okamoto, S. Sato, T. Takeuchi, T. Watanabe.

    Fish & Shellfish Immunology   2004.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • In vivo priming of TNP-reactive effector cells in carp. Reviewed

    Satoshi Hasegawa, Tomonori Somamoto, Maria Raquel Moura Coimbra, Nobuaki Okamoto.

    Fish Pathology   1999.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • A cell line (CFK) from fin of isogeneic ginbuna crucian carp. Reviewed

    Satoshi Hasegawa, Tomonori Somamoto, Chihaya Nakayasu, Teruyuki Nakanishi, Nobuaki Okamoto.

    Fish Pathology   1997.1

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    Language：English   Publishing type：Research paper (scientific journal)  

▼display all

Books

  • Fish Immunology. In Aquaculture Pathophysiology: FINFISH DISEASES

    Tomonori Somamoto, Teruyuki Nakanishi.（Role：Joint author）

    Elsevier-Academic Press.  2022.8 

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    Responsible for pages：Chapter 6. pp.95-119 (edited by Frederick S.B. Kibenge, Bernardo Baldisserotto, and Roger Sie-Maen Chong)：Paperback ISBN: 9780128122112.   Language：English   Book type：Scholarly book

  • The evolution of complement system functions and pathways in vertebrates. in THE EVOLUTION OF THE IMMUNE SYSTEM: A BALANCE BETWEEN CONSERVATION AND DIVERSITY,

    中尾 実樹, 杣本 智軌（Role：Joint author）

    Elsevier  2016.7 

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    Responsible for pages：chapter 6,152-171   Language：English  

  • 補体への招待　「2.5.2. 補体系の進化：脊椎動物」(大井洋之、木下タロウ、松下操　編)

    中尾　実樹　杣本　智軌（Role：Joint author）

    2011.4 

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    Language：Japanese   Book type：General book, introductory book for general audience

Presentations

  • Preventing parasitic infections caused by Ichthyophthirius multifiliis: A novel approach with a　single-chain variable fragment (scFv)-conjugated affinity silk filter device

    Harsha Prakash・Mitsuru Sato・Katsura Kojima・Chisato Sakuma・Akhil Kizhakkumpat・Takahiro Nagasawa・Miki Nakao・Tomonori Somamoto,

    日本魚病学会春季大会  2024.3 

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    Event date： 2024.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：東京海洋大学   Country：Japan  

  • シルクタンパク質を利⽤した陸上養殖の感染症予防システムの開発 Invited

    杣本智軌

    第3回公開シンポジウム　農林水産物の輸出促進研究プラットフォーム＠九州・沖縄  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Country：Japan  

  • The expression of CD83 homologs on macrophage subpopulations isolated from brain and kidney in ginbuna crucian carp

    Tran Thu Trang, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    日本水産学会春季大会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学   Country：Japan  

  • 硬骨魚類の病原体に対する細胞性免疫機構 Invited

    杣本智軌

    令和5年度日本水産学会九州支部大会・ミニシンポジウム  2023.12 

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    Event date： 2023.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：宮崎県企業局・県電ホール   Country：Japan  

  • Expression of CD83 isotypes during the differentiation of monocyte-macrophage lineage in ginbuna crucian carp

    Tran Thu Trang, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto,

    日本比較免疫学会学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州大学伊都キャンパス   Country：Japan  

  • ギンブナ後腸部に存在する嚢状組織のリンパ組織としての特性

    浅沼里利香、長澤貴宏、中尾実樹、杣本智軌,

    日本比較免疫学会学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州大学伊都キャンパス   Country：Japan  

  • Characterization of CD83 isotypes expressed on monocyte-macrophage lineage in ginbuna crucian carp International conference

    Tran Thu Trang, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    15th Congress of the International Society for Developmental and Comparative Immunology (ISDCI)  2023.7 

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    Event date： 2023.7

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Wageningen University   Country：Japan  

  • Differential expression of two CD83 isotypes in monocyte-macrophage lineage in ginbuna crucian carp

    Thu Trang Tran, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    日本水産学会春季大会  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学（東京都港区）   Country：Japan  

  • 魚類の病原体に対する細胞性免疫に関する研究 Invited

    杣本智軌

    日本魚病学会  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：日本大学（神奈川県藤沢市）   Country：Japan  

  • Characterization of CD83 isotypes expressed in monocyte and monocyte-derived dendritic-like cells in ginbuna crucian carp

    Thu Trang Tran, Harsha Prakash, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    日本水産学会秋季大会  2022.9 

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    Event date： 2022.9

    Language：English   Presentation type：Oral presentation (general)  

    Venue：フェニックス・シーガイア・リゾート（宮崎市）   Country：Japan  

  • ギンブナの粘膜T細胞の自然免疫機能

    森岡拓也・趙舸・長澤貴宏・中尾実樹・杣本智軌

    日本水産学会秋季大会  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：フェニックス・シーガイア・リゾート（宮崎市）   Country：Japan  

  • Development of single chain variable fragment (scFv) conjugated affinity silk for the detection of Ichthyophthirius multifiliis

    Harsha Prakash, Mitsuru Sato, Katsura Kojima, Atsushi Sato,Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    日本魚病学会  2022.3 

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    Event date： 2022.3

    Language：English   Presentation type：Oral presentation (general)  

    Venue：オンライン　（主催　東京海洋大学）   Country：Japan  

  • フナ造血器壊死ウイルス（CHNV）に対するDNAワクチン

    高野倫一・松浦雄太・梅田剛佑・吉野友晃（水産機構水技研）中西照幸（ゴトー養殖研究所）・松山知正（水産機構水技研）・杣本智軌（九大院農）

    日本魚病学会春季大会  2022.3 

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    Event date： 2022.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京海洋大学　オンライン   Country：Japan  

  • Exploration of antigen-trapping sites in ginbuna crucian carp

    呉雨・長澤貴宏・中尾実樹・杣本智軌

    日本水産学会九州支部会  2022.1 

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    Event date： 2022.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン　（九州大学）   Country：Japan  

  • Characterization of cell surface receptor NCCRP-1 on CD8+T cells of Ginbuna　crucian carp in the cytotoxic activity against Ichthyophthirius multifiliis

    Prakash H, Sukeda M, Nawasawa T, Nakao M, Somamoto T,

    日本水産学会秋季大会  2021.9 

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    Event date： 2021.9

    Language：English  

    Venue：オンライン　（主催　北海道大学　函館）   Country：Japan  

  • 粘膜組織を介した抗原投与法の違いによるギンブナ抗体産生応答の比較

    阪中晴子・長澤貴宏、中尾実樹、杣本智軌

    日本魚病学会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン　（北海道大学　函館）   Country：Japan  

  • The interaction between Koi Herpesvirus and a CD46-like regulator of complement activation in teleost.

    Nguyen Quang Khai, Harsha Prakash, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    日本魚病学会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン　（北海道大学　函館）   Country：Japan  

  • 魚類リポカリンタンパク質 TBT-bp2 破壊メダカにおける白点虫感染機構の解析

    ＃高井優生,# 助田将樹, #高村匠, #長野陽介, 島崎洋平, 杣本智軌, 大嶋雄治

    日本水産学会春季大会  2021.3 

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    Event date： 2021.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 魚類CD8+ T細胞のMHC非依存的な細胞媒介性細胞傷害における寄生原虫認識受容体の探索

    #助田将樹,長澤貴宏,中尾実樹,杣本智軌

    日本水産学会春季大会  2021.3 

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    Event date： 2021.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • Phagocytosis of CD8α+ T cell in ginbuna crucian carp, Carassius auratus langsdorfii

    #Zhao Ge,@ Takahiro Nagasawa, @Miki Nakao, @Tomonori Somamoto.

    日本水産学九州支部大会  2019.12 

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    Event date： 2019.12

    Language：English   Presentation type：Oral presentation (general)  

    Venue：鹿児島大学（鹿児島市）   Country：Japan  

  • アフィニティーシルクを用いた魚病細菌除去フィルターの開発

    Harsha Prakash、丸山真平、佐藤充、小島桂、佐藤巧視、長澤貴宏、中尾実樹、杣本智軌

    日本魚病学会  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：フェニックス・プラザ（福井市）   Country：Japan  

  • Direct cytotoxic activity of CD8+ T cells against Ichthyophthirius multifiliis in ginbuna crucian carp, Carrassius auratus langsforfii International conference

    Masaki Sukeda, Koumei Shiota, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto,

    3rd International Conference of Fish and Shellfish Immunology  2019.6 

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    Event date： 2019.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Las Palmas de Gran Canaria,   Country：Spain  

  • 塩田昂明, 助田将樹, 中西照幸, 長澤 貴宏, 杣本智軌, 中尾実樹

    繊毛虫Ichtyophthirius multifiliisの成長段階の違いによるギンブナの免疫応答の比較

    日本水産学会春季大会  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 繊毛虫Ichthyophthirius multifiliisに対する魚類CD8+T細胞の傷害機構

    助田将樹,長沢貴宏,中尾実樹,杣本智軌

    日本魚病学会秋季大会  2017.9 

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    Event date： 2018.9

    Language：Japanese  

    Venue：宮崎市   Country：Japan  

  • ギンブナCD8+Tリンパ球の寄生原虫に対する細胞遊走活性

    助田将樹・塩田昴明・長沢貴宏・中尾実樹・杣本智軌

    日本水産学会秋季大会  2018.9 

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    Event date： 2018.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：広島大学　東広島市   Country：Japan  

  • ギンブナCD8+Tリンパ球の細胞外寄生原虫に対する細胞障害機構の解明

    助田将樹, 長澤 貴宏, 中尾 実樹, 杣本智軌

    日本水産学会春季大会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Tokyo   Country：Japan  

  • 卵黄抗体で鯉の穴あき病予防 Invited

    杣本智軌

    日本たまご研究会  2017.11 

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    Event date： 2017.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都女子大学   Country：Japan  

  • アフィニティーシルクの魚病細菌感染症診断への応

    #丸山真平,佐藤充,小島桂,佐藤巧視,@長沢貴宏,@中尾実樹,@杣本智軌

    日本魚病学会秋季大会  2017.9 

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    Event date： 2017.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：宮崎市   Country：Japan  

  • 繊毛虫 Ichthyophthirius multiliis に対するギンブナT 細胞の傷害活性

    助田将樹, 長澤 貴宏, 中尾 実樹, 杣本智軌

    日本水産学会春季大会  2017.3 

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    Event date： 2017.3

    Language：Japanese  

    Venue：東京海洋大学   Country：Japan  

  • ギンブナの細胞性免疫抑制によるKHV病発症

    新内悠介, 満崎敬子, 福田圭佑, 長澤 貴宏, 中尾 実樹, 杣本智軌

    日本水産学会春季大会  2017.3 

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    Event date： 2017.3

    Language：Japanese  

    Venue：東京海洋大学   Country：Japan  

  • 穴あき病原因菌非定型A. salmonicidaに対する感受性の魚種･品種間比較

    藤原もも, 丸山　真平, 佐藤巧視, 長澤 貴宏, 中尾 実樹, 杣本智軌

    日本魚病学会秋季大会  2016.9 

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    Event date： 2016.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：近畿大学（奈良市）   Country：Japan  

  • Induction of T cell immunity by intentional immunization with inactivated virus in ginbuna crucain carp International conference

    Seisuke Tajimi, Tomonori　Somamoto, Teruyuki Nakanishi, Miki Nakao

    13th Congress of the International Society for Developmental and Comparative Immunology  2015.6 

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    Event date： 2015.6 - 2015.7

    Language：English  

    Venue：Murucia   Country：Spain  

  • Characterizations of membrane-bound complement regulatory protein in Ginbuna Crucian Carp Carassius auratus langsdorfii

    Indriyani Nur, Hikari Harada, Ryota Nakamura, Masakazu Tsujikura, Tomonori Somamoto, Miki Nakao

    日本比較免疫学会  2013.8 

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    Event date： 2013.8

    Language：English   Presentation type：Oral presentation (general)  

    Venue：岡山理科大学   Country：Japan  

  • ギンブナ樹状細胞マーカー CD83 に対する抗体の作製と発現

    豊福太樹, 山下基子, 長沢貴宏, 杣本 智軌, 中尾 実樹

    日本水産学会春季大会  2013.3 

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    Event date： 2013.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大   Country：Japan  

  • ギンブナにおけるコイヘルペスウイルスに対する防御機構の解明

    福田圭佑, 杣本 智軌, 中尾 実樹

    日本水産学会九州支部大会  2013.1 

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    Event date： 2013.1

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • Functions of CD8-positive and CD4-positive lymphocytes against virus-infection　in ginbuna crucain carp International conference

    Tomonori Somamoto, Teruyuki Nakanishi, Miki Nakao

    12th Congress of International Society of Developmental and Comparative Immunology  2012.7 

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    Event date： 2012.7

    Presentation type：Oral presentation (general)  

    Venue：Fukuoka city, Hilton Fukuoka Sea Hawk Hotel   Country：Japan  

  • 魚類の細胞性免疫機構について

    中西照幸、杣本智軌、柴崎康宏、藪健史

    第153回日本獣医学会微生物分科会シン ポジウム  2012.3 

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    Event date： 2012.3

    Venue：大宮ソニックシティ   Country：Japan  

  • 不活化ウイルス経腸管感作後のギンブナT細胞の免疫応答

    多治見誠亮・杣本智軌・中西照幸・中尾実樹

    日本水産学会九州支部大会  2012.1 

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    Event date： 2012.1

    Presentation type：Oral presentation (general)  

    Venue：鹿児島大学   Country：Japan  

  • Rag1欠損ゼブラフィッシュにおける獲得免疫不全の検証

    白水 正道・徳永 弓枝・吉浦 康寿、乙竹 充・杣本 智軌・中尾 実樹

    第23回日本比較免疫学会  2011.8 

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    Event date： 2011.8

    Presentation type：Oral presentation (general)  

    Venue：独立行政法人海洋研究開発機構（横浜市）   Country：Japan  

  • ウイルス感染で誘導されたギンブナ細胞傷害T細胞と単球の細胞傷害活性

    杣本 智軌、中西 照幸、中尾 実樹

    第22回日本比較免疫学会  2010.8 

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    Event date： 2010.8 - 2011.5

    Venue：九州大学   Country：Japan  

  • コイ栓球は異物を貪食する

    長澤貴宏・中易千早・杣本智軌・中尾実樹,

    日本比較免疫学会  2009.8 

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    Event date： 2009.8

    Presentation type：Oral presentation (general)  

    Venue：日本大学   Country：Japan  

  • ギンブナFas ligandのcDNAクローニングと発現解析

    中村一規・杣本智軌・中西照幸・中尾実樹,

    日本比較免疫学会  2009.8 

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    Event date： 2009.8

    Presentation type：Oral presentation (general)  

    Venue：日本大学   Country：Japan  

  • Characterization of MHC class I genes in clonal ginbuna crucian carp, Carassius auratus langsdorfii International conference

    Shinichi Urabe, Tomonori Somamoto, Shiro Sameshima, Teruyuki Nakanishi, Mitsuru Ototake, and Miki Nakao,

    11th Congress of International Society of Developmental and Comparative Immunology  2009.6 

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    Event date： 2009.6 - 2009.7

    Presentation type：Symposium, workshop panel (public)  

    Venue：Prague,Czech Republic   Country：Japan  

  • コイ栓球の免疫機能解析

    長沢貴宏・杣本智軌・中尾実樹

    日本水産学会  2009.3 

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    Event date： 2009.3 - 2009.4

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • ギンブナのウイルスに対する細胞性免疫応答 Invited

    杣本智軌

    シンポジウム「ウイルス感染防御のための魚類細胞性免疫機構の解明」  2009.3 

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    Event date： 2009.3

    Presentation type：Oral presentation (invited, special)  

    Venue：日本大学   Country：Japan  

  • ギンブナ2B4様分子

    鮫島史朗・鵜木陽子・杣本智軌・中尾実樹

    水産学会九州支部大会  2009.1 

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    Event date： 2009.1

    Venue：長崎大学   Country：Japan  

  • ウイルス感染時におけるギンブナMHC class I遺伝子の発現動態

    占部慎二・鮫島史朗・杣本智軌・中尾実樹

    水産学会九州支部大会  2009.1 

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    Event date： 2009.1

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • ギンブナ由来細胞株における4種のMHCクラスI遺伝子のクローニングおよび、CHNV感染後の発現動態

    占部慎二、鮫島史朗、杣本智軌、中西照幸、中尾実樹

    日本比較免疫学会  2008.8 

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    Event date： 2008.11

    Country：Japan  

  • コイ補体C1qのcDNAクローニング

    杣本智軌・Vo Kha Tam・加藤陽子・中尾実樹

    日本水産学会  2006.4 

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    Presentation type：Oral presentation (general)  

    Venue：高知   Country：Japan  

  • Molecular cloning and characterization of the complement C1q A, B, and C chains in common carp. International conference

    Tomonori Somamoto, Vo Kha Tam, Miki Nakao

    10th International Society of Developmental and Comparative Immunology Congress  2006.6 

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    Presentation type：Oral presentation (general)  

    Venue：South Carolina   Country：United States  

  • Molecular cloning and characterization of CD4 in ginbuna crucian carp. International conference

    Seiko Nonaka, Tomonori Somamoto, Yoko Kato, Mitsuru Ototake, Teruyuki Nakanishi, and Miki Nakao.

    10th International Society of Developmental and Comparative Immunology Congress  2006.6 

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    Presentation type：Oral presentation (general)  

    Venue：South Carolina   Country：United States  

  • コイ補体C1q A, B, C鎖のcDNAのクローニング

    杣本智軌・Vo Kha Tam・加藤陽子・中尾実樹

    補体シンポジウム  2006.8 

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    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • ギンブナ頭腎、体腎、脾臓の Expressed Sequence Tag 解析

    鮫島史朗、鵜木陽子、杣本智軌、中尾実樹,

    日本比較免疫学会  2007.8 

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    Country：Japan  

  • クローンギンブナ由来細胞株におけるMHCクラスＩによる抗原提示機構関連遺伝子のクローニング

    杣本智軌、占部慎二、鮫島史朗、中西照幸、中尾実樹

    日本比較免疫学会  2007.8 

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    Country：Japan  

  • ２種類のギンブナ CD4 様分子

    野中誠子･杣本智軌･中西照幸･乙竹充･中尾実樹

    日本水産学会九州支部会  2008.1 

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    Country：Japan  

  • ウイルス特異的傷害活性を有するギンブナ培養リンパ球のCD8αとTCRβのmRNAの発現解析

    杣本智軌、中西照幸 、乙竹充、中尾実樹

    日本水産学会  2008.3 

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    Country：Japan  

  • 鶏卵抗体の浸漬投与によるニシキゴイの穴あき病の予防法の確立

    甘　鴻剣, 何海文, 佐藤巧視, 八田一, 中尾 実樹, 杣本智軌

    日本魚病学会  2013.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 不活化ウイルスの経腸管感作によって誘導されるギンブナT細胞の免疫応答及び感染防御効果

    多治見　誠亮, 杣本智軌, 中西　照幸, 中尾 実樹

    日本水産学会春季大会  2013.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 穴あき病発症時におけるコイ補体成分の組織内分布

    前田佑佳, 杣本 智軌, 鶴田幸成, 中尾 実樹

    日本水産学会春季大会  2015.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイとギンブナにおけるコイヘルペスウイルスへの免疫応答の比較

    満崎敬子, 中尾 実樹, 杣本 智軌

    日本水産学会春季大会  2015.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大   Country：Japan  

  • 鯉ヘルペスウイルスの感染抗原に対する鶏卵抗体(IgY)の調製

    八田一, 杣本 智軌, 佐藤巧視, 森本金次郎

    日本農芸化学会  2015.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：岡山大学   Country：Japan  

  • Development of anti-peptide antibody specific for IgM heavy chain of Oryzias latipes and its application to assay of immune response triggered by BSA-coated microplastics

    Akhil Kizhakkumpat, Mako I, Prakash H, Nagasawa T, Somamoto T, Nakao M,

    日本水産学会春季大会  2024.3 

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    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学   Country：Japan  

  • エドワジエラ症耐性ヒラメの粘膜免疫因子の探索

    椿野 鈴, 吉井 啓亮, 岡本 裕之,　大野 薫,　牧野 由美子,　長澤 貴宏,　杣本 智軌,　中尾 実樹

    日本比較免疫学会学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州大学伊都キャンパス   Country：Japan  

  • Molecular cloning of zymosan-binding lectin in the banded houndshark (Triakis scyllium)

    Zhu J, Nagasawa T, Somamoto T, Nakao M,

    日本比較免疫学会学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイ(Cyprinus carpio)栓球はToll様受容体を介して抗原特異的に応答する

    笠　元、長澤貴宏、杣本智軌、中尾実樹,

    日本比較免疫学会学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州大学伊都キャンパス   Country：Japan  

  • コイ血清中の溶血反応阻害タンパク質の精製と同定

    金田誠正、長澤貴宏、杣本智軌、中尾実樹

    日本補体学会学術集会  2023.8 

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    Event date： 2023.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Ligand specificity and active signaling of common carp (Cyprinus carpio) thrombocytes via toll-like receptor pathways International conference

    Tsukasa Ryu, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    15th Congress of the International Society for Developmental and Comparative Immunology (ISDCI)  2023.7 

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    Event date： 2023.7

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Wageningen University   Country：Japan  

  • コイの可溶性補体制御因子の精製 Invited

    金田誠正・長澤貴宏・杣本智軌・中尾実樹

    日本水産学会春季大会  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：日本大学（神奈川県藤沢市）   Country：Japan  

  • 魚類におけるC3の細胞内活性化の可能性

    又吉百音・長澤貴宏・杣本智軌・中尾実樹

    日本補体学会学術集会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：酪農学園大学 （北海道）   Country：Japan  

  • 細胞内補体活性化の系統発生学的検討:コイ末梢血白血球における補体C3の断片化

    又吉百音, 長澤貴宏, 杣本智軌, 中尾実樹

    日本比較免疫学会学術集会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイ(Cyprinus carpio)栓球による免疫応答のパターン認識機構

    笠 元、長澤貴宏、 杣本智軌、中尾実樹

    日本水産学会秋季大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン　（北海道大学　函館）   Country：Japan  

  • コイ体表粘液中の補体成分と補体活性化

    吉迫郁子・長澤貴宏・杣本智軌・中尾実樹,

    日本補体学会学術集会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：千里ライフサイエンスセンター (大阪）   Country：Japan  

  • コイ血清中におけるC3の二量体形成

    畠山紗矢香・長澤貴宏・杣本智軌・中尾実樹,

    日本補体学会学術集会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：千里ライフサイエンスセンター (大阪）   Country：Japan  

  • Adsorption of protein and bacteria on microplastics: Effect on oral intake and adaptive immunity of Oryzias latipes

    Akhil K, Nawasawa T, Somamoto T, Oshima Y, Nakao M.

    日本水産学会秋季大会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン　（主催　北海道大学　函館）   Country：Japan  

  • コイ体表粘液中に存在する補体成分と粘液における補体活性化

    吉迫郁子, 長澤貴宏, 杣本智軌, 中尾実樹

    日本比較免疫学会学術集会  2021.8 

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    Event date： 2021.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン　（主催　水産大学校　下関）   Country：Japan  

  • ドチザメ血清中のザイモサン結合レクチンの同定と発現解析

    朱 珈凝, 友井千帆里, 長澤貴宏, 杣本智軌, 中尾実樹

    日本比較免疫学会学術集会  2021.8 

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    Event date： 2021.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン　（主催　水産大学校　下関）   Country：Japan  

  • アユカリクレクチンはオプソニンとして働く

    長澤貴宏,池尻夏菜,大野　薫,牧野由美子,笠　元,杣本智軌,中尾実樹

    日本水産学会春季大会  2021.3 

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    Event date： 2021.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 魚類における補体成分C3の細胞内活性化 Invited

    #又吉百音,長澤貴宏,杣本智軌,中尾実樹

    日本水産学会九州支部大会  2021.1 

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    Event date： 2021.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • 野生型および魚類リポカリンタンパク質 TBT-bp2 遺伝子 破壊メダカを用いた白点虫感染実験

    ＃高井優生＃助田将樹＃高村匠＃長野陽介@島崎洋平@杣本智軌@大嶋雄治

    日本水産学会春季大会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学（東京都港区）   Country：Japan  

  • アユのザイモサン結合性レクチンの機能解析

    長澤貴宏・池尻夏菜・杣本智軌・中尾実樹

    日本水産学会春季大会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • ギンブナの細胞外寄生原虫に対する細胞傷害機構におけるシグナル伝達経路の探索

    #助田将樹、＠長澤貴宏、＃塩田昂明、＠中尾実樹・＠杣本智軌

    日本水産学会春季大会  2020.3 

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学（東京都港区）   Country：Japan  

  • 魚類炎症反応におけるC5aの役割解明のための組換えゼブラフィッシュ C5aの作製

    #齋藤武尊・@長澤貴宏・@杣本智軌・@中尾実樹,

    日本水産学会秋季大会  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福井県立大学   Country：Japan  

  • ドチザメ血清中のザイモサン結合タンパク質の同定

    友井千帆里, 長澤貴宏, 濵　虹花, 杣本智軌, 中尾実樹

    日本比較免疫学会  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州大学   Country：Japan  

  • Nehlah Rosli・Akira Yamamoto・Takahiro Nagasawa・Tomonori Somamoto・Miki Nakao.

    Functional analysis of two complement C4 isotypes of carp using recombinant proteins

    日本水産学会秋季大会  2018.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：広島大学　東広島市   Country：Japan  

  • 特異抗体を利用したコイ補体成分C5の迅速精製

    中尾実樹, 木村美智代, 長澤 貴宏, 杣本智軌.

    日本水産学会春季大会  2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学　港区   Country：Japan  

  • 魚類炎症反応におけるC5aの役割解明のための抗ゼブラフィッシュC5a抗体の作成

    斎藤武尊, 長澤 貴宏, 杣本智軌, 中尾実樹,

    日本水産学会春季大会  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学   Country：Japan  

  • コイ体表粘液中に存在する補体成分の検出

    吉迫郁子, 黒木将武, 長澤貴宏, 杣本智軌, 中尾実樹,

    日本比較免疫学会学術集会  2018.8 

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    Event date： 2018.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：日本大学生物資源科学部　藤沢市   Country：Japan  

  • Evolutionary implication on the function of the classical pathway of the complement system, Asian Invertebrate Immunity Symposium, 2018.09. International conference

    Nakao　M, Iwanaga　S, Nagasawa　T, Somamoto　T.

    Asian Invertebrate Immunity Symposium  2018.8 

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    Event date： 2018.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：fukuoka   Country：Japan  

  • Type I IFN production by carp thrombocytes as professional antiviral leukocytes, like mammalian plasmacytoid dendritic cells, via IRF signaling pathway International conference

    Nagasawa　T, Somamoto　T, Nakao　M,

    Asian Invertebrate Immunity Symposium  2018.8 

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    Event date： 2018.8

    Language：English   Presentation type：Oral presentation (general)  

    Venue：fukuoka   Country：Japan  

  • 硬骨魚類における古典経路の機能解析から系統発生学的考察

    中尾実樹, 岩永彩代、長沢貴宏、杣本智軌

    日本補体学会学術集会  2018.8 

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    Event date： 2018.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州市   Country：Japan  

  • Viral ligands recognition of carp thrombocytes as natural type I interferon producing cells International conference

    Nagasawa　T,Somamoto T, Nakao　M.

    14th Congress of International Society of Developmental and Comparative Immunology  2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Santa Fe, New Mexico, USA   Country：Japan  

  • Phylogenetic inference on functions of the classical complement pathway in bony fish, 14th Congress of International Society of Developmental and Comparative Immunology International conference

    Nakao　M, Iwanaga　S, Nagasawa　T, Somamoto　T,

    14th Congress of International Society of Developmental and Comparative Immunology  2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Santa Fe, New Mexico, USA   Country：Japan  

  • Homeostatic functional analysis of Tecrem, a CD46-like complement regulatory protein, on epithelial cells in carp fish

    Prakash H, Motobe S, Nagasawa T, Somamoto T, Nakao M

    日本水産学会春季大会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Tokyo   Country：Japan  

  • トラフグカリクレクチンの局在と機能

    鈴木悠也・澁谷航・中村修（北里大海洋）杣本智軌（九大院農）田角聡志（東大水実）○筒井繁行（北里大海洋）

    日本水産学会春季大会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学   Country：Japan  

  • コイ栓球によるI型インターフェロン産生機構

    長沢貴宏,杣本智軌,中尾実樹

    日本魚病学会秋季大会  2017.9 

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    Event date： 2017.9 - 2018.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：宮崎市   Country：Japan  

  • Functional diversity of two C7 isotypes in bony fish, a primitive vertebrate model International conference

    Nakao M, Noguchi M, Akahoshi S, Nagasawa T, Somamoto T,

    European Meeting on Complement in Human Disease  2017.9 

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    Event date： 2017.9

    Language：Japanese  

    Venue：Copenhagen   Country：Japan  

  • Functional analysis of Tecrem, a CD46-like complement regulatory protein, on epithelial cells in the common carp International conference

    Prakash H, Motobe S, Nagasawa T, Somamoto T, Nakao M,

    The JSFS 85th Anniversary-Commemorative International Symposium  2017.9 

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    Event date： 2017.9

    Language：Japanese  

    Venue：Tokyo   Country：Japan  

  • コイ補体成分B/C2-Bの組換え体作成と機能解析

    赤司小百合、長沢貴宏、杣本智軌、中尾実樹

    日本比較免疫学会学術集会  2017.8 

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    Event date： 2017.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北海道大学　札幌   Country：Japan  

  • コイ補体C7アイソタイプの機能解析

    野口真代、長沢貴宏、杣本智軌、中尾実樹,

    日本補体学会学術集会  2017.8 

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    Event date： 2017.8

    Language：Japanese  

    Country：Japan  

  • コイ補体Properdinアイソタイプの機能解析

    黒木将武、吉岡和紀、長沢貴宏、杣本智軌、中尾実樹

    日本補体学会学術集会  2017.8 

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    Event date： 2017.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：コラッセふくしま （福島）   Country：Japan  

  • コイ補体 C7 アイソタイプの機能解析

    野口真代, 長澤 貴宏, 杣本智軌, 中尾 実樹

    日本水産学会春季大会  2017.3 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学   Country：Japan  

  • Expression and homeostatic functions of Tecrem, a CD46-like complement regulatory protein on epithelial cells in bony fish. International conference

    Harsha Prakash, Shiori Motobe, Takahiro Nagasawa, Tomonori　Somamoto, Miki　Nakao

    26th International Complement Workshop  2016.9 

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    Event date： 2016.9 - 2017.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：Kanazawa   Country：Japan  

  • Carp properdin: structural and functional diversity of two isotypes International conference

    Kazuki Yoshioka, Yoko Kato-Unoki, Takahiro　Nagasawa, Tomonori　Somamoto, Miki　Nakao

    26th International Complement Workshop  2016.9 

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    Event date： 2016.9

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Kanazawa   Country：Japan  

  • コイ血清レクチン（MFAP4）の構造および機能解析

    木村美智代, 畑中大作, 一木昭土, 長澤 貴宏, 杣本智軌, 中尾 実樹

    日本比較免疫学会学術集会  2016.8 

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    Event date： 2016.8 - 2017.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：日本医科歯科大学   Country：Japan  

  • 魚類好中球の異物取り込み・付着を判別する新手法

    長澤 貴宏, 杣本智軌, 中尾 実樹

    日本比較免疫学会学術集会  2016.8 

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    Event date： 2016.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：日本医科歯科大学   Country：Japan  

  • Carp thrombocyte phagocytosis needs activation factors secreted from other leukocyte population. International conference

    Takahiro Nagasawa, Tomonori　Somamoto, Miki Nakao

    13th Congress of the International Society for Developmental and Comparative Immunology  2015.6 

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    Event date： 2016.6 - 2016.7

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Murucia   Country：Spain  

  • 大豆タンパク質含有飼料が魚類の抗体産生応答に与える影響

    岡田幸浩, 畑中晃昌, 青木直人, 平澤徳高, 梅田奈央子, 長澤貴宏, 杣本 智軌, 中尾 実樹

    日本水産学会春季大会  2016.3 

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    Event date： 2016.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学, 東京都港区   Country：Japan  

  • 獲得免疫欠損ゼブラフィッシュにおけるミエロペルオキシダーゼ遺伝子のノックアウト

    鵜木（加藤）陽子, 杣本 智軌, 中尾 実樹

    日本水産学会春季大会  2016.3 

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    Event date： 2016.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大学, 東京都港区   Country：Japan  

  • コイ補体成分C5の精製

    世戸口牧子, 杣本 智軌, 中尾 実樹

    日本比較免疫学会学術集会  2015.8 

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    Event date： 2015.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福井県立大学、小浜市   Country：Japan  

  • Structural and functional diversity of properdin isotypes in the common carp complement system. International conference

    Kazuki Yoshioka, Yoko Kato-Unoki, Tomonori　Somamoto, Miki　Nakao

    13th Congress of the International Society for Developmental and Comparative Immunology  2015.6 

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    Event date： 2015.6 - 2015.7

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Murucia   Country：Spain  

  • コイＢ細胞における自然免疫活性化能

    赤木　良太, 長沢　貴宏, 杣本 智軌, 中尾　実樹

    日本水産学会九州支部会  2015.1 

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    Event date： 2015.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：宮崎市民プラザ、宮崎市   Country：Japan  

  • Rag1欠損ゼブラフィッシュの免疫調節機構

    菅原亮太, 吉浦康寿, 杣本 智軌, 中尾　実樹

    日本水産学会秋季大会  2014.9 

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    Event date： 2014.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州大学、福岡   Country：Japan  

  • コイ補体 Properdin アイソフォームの多様性と機能解析

    吉岡　和紀, 鵜木　陽子, 杣本 智軌, 中尾　実樹

    日本比較免疫学会  2014.7 

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    Event date： 2014.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東北大学、仙台   Country：Japan  

  • Preparation of anti-Koi Herpes Virus IgY and its prophylactic effect International conference

    Hajime Hatta, Somamoto T, Atsushi. Satou, Kinjiro Morimoto

    WROCŁAW EGG BANFF FORUM CONFERENCE  2014.6 

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    Event date： 2014.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Wrocław   Country：Poland  

  • コイ栓球は他の白血球により活性化され貪食能を示す

    長沢貴宏, 中易千早, 杣本 智軌, 中尾 実樹

    日本水産学会春季大会  2013.3 

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    Event date： 2013.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大   Country：Japan  

  • 穴あき病発症時におけるコイ補体成分の組織内

    前田佑佳, 杣本 智軌, 鶴田幸成, 中尾 実樹

    日本水産学会春季大会  2013.3 

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    Event date： 2013.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京海洋大   Country：Japan  

  • コイ補体成分 Properdinの cDNA クローニングと構造解析

    鵜木（加藤）陽子・辻倉正和・一木智子・杣本智軌・中尾実樹

    日本水産学会九州支部大会  2013.1 

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    Event date： 2013.1

    Presentation type：Oral presentation (general)  

    Venue：九州大学   Country：Japan  

  • Rag1欠損ゼブラフィッシュにおけるT細胞の機能不全の検証

    白水正道, 杣本 智軌, 吉浦康寿, 中尾 実樹

    日本水産学会九州支部大会  2013.1 

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    Event date： 2013.1

    Presentation type：Oral presentation (general)  

    Venue：九州大学   Country：Japan  

  • コイ膜型補体制御因子 cTecrem のモノクローナル抗体作製と機能解析

    中村亮太・辻倉正和・中尾実樹・杣本智軌

    日本水産学会九州支部大会  2013.1 

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    Event date： 2013.1

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • 魚類CD46様補体制御因子の多様性と機能解析

    中尾実樹、中村亮太、原田光、長澤貴宏、Indriyani Nur、辻倉正和、一木智子、杣本智軌

    補体シンポジウム  2012.8 

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    Event date： 2012.8

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • Isotypic Diversity in the Ontogenetic Expression of the Complement Componentin the Common Carp (Cyprinus carpio) International conference

    Vo Kha Tam, Chie Okura, Masakazu Kondo, Tomonori Somamoto, Miki Nakao

    12th Congress of International Society of Developmental and Comparative Immunology  2012.7 

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    Event date： 2012.7

    Presentation type：Oral presentation (general)  

    Venue：Fukuoka city, Hilton Fukuoka Sea Hawk Hotel   Country：Japan  

  • Characterization of culture supernatant of Streptococcus parauberis: hemolytic factor and leucocyte-stimulation in Japanese flounder International conference

    Haruka Tsukamoto, Yutaka Fukuda, Tomonori Somamoto, Miki Nakao

    12th Congress of International Society of Developmental and Comparative Immunology  2012.7 

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    Event date： 2012.7

    Presentation type：Oral presentation (general)  

    Venue：Fukuoka city, Hilton Fukuoka Sea Hawk Hotel   Country：Japan  

  • Phagocytosis and bactericidal abilities of teleost thrombocytes International conference

    Takahiro Nagasawa, Chihaya Nakayasu, Tomomasa Matsuyama, Aja M. Rieger, Daniel R. Barreda, Tomonori Somamoto, Miki Nakao

    12th Congress of International Society of Developmental and Comparative Immunology  2012.7 

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    Event date： 2012.7

    Presentation type：Oral presentation (general)  

    Venue：Fukuoka city, Hilton Fukuoka Sea Hawk Hotel   Country：Japan  

  • 魚類栓球の異物貪食作用

    長澤貴宏・松山知正・中易千早・杣本智軌・中尾実樹,

    日本水産学会春季大会  2011.3 

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    Event date： 2012.3

    Venue：東京海洋大学   Country：Japan  

  • Streptococcus parauberisに対するヒラメ白血球の活性化

    塚本春香・杣本智軌・中尾実樹

    日本水産学会春季大会  2012.3 

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    Event date： 2012.3

    Presentation type：Oral presentation (general)  

    Venue：東京海洋大学   Country：Japan  

  • ｒａｇ‐１遺伝子欠損によるゼブラフィッシュの獲得免疫不全の検証と遺伝子の発現変動

    徳​永​弓​枝･白​水​正​道･安​住​薫･吉​浦​康​寿･乙​竹​充･田​代​康​介･杣​本​智​軌･中​尾​実​樹

    日本水産学会秋季大会  2011.10 

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    Event date： 2011.9 - 2012.10

    Presentation type：Oral presentation (general)  

    Venue：長崎大学   Country：Japan  

  • コイ補体成分C4 アイソタイプ(C4-1,C4-2)の結合特異性の解析

    山本暁、一木智子、杣本智軌、中尾実樹

    補体シンポジウム  2011.9 

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    Event date： 2011.9

    Presentation type：Oral presentation (general)  

    Venue：名古屋市立大学   Country：Japan  

  • コイC3 アイソタイプの機能解析

    一木智子･鵜木(加藤)陽子･杣本智軌･中尾実樹

    補体シンポジウム  2011.9 

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    Event date： 2011.9

    Venue：名古屋市立大学   Country：Japan  

  • 魚類栓球の貪食作用とその活性科に伴う形態変化

    長沢貴宏･中易千早･松山知正･杣本智軌･中尾実樹

    第23回日本比較免疫学会  2011.8 

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    Event date： 2011.8

    Presentation type：Oral presentation (general)  

    Venue：海洋研究開発機構、横浜   Country：Japan  

  • 魚類の細胞性免疫機構について

    中西照幸、杣本智軌、戸田秀明、柴崎康宏、藪健史

    第151回日本獣医学会　微生物シンポジウム２  2011.3 

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    Event date： 2011.3

    Country：Japan  

  • Function of diversity of the complement component isotypes in bony fish innate immunity: A model study using the common carp Invited International conference

    Nakao M, Ichiki S, Mutsuro J, Tsujikura M, Somamoto T.

    The ninth International Congress on the Biologyof Fish  2010.9 

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    Event date： 2010.9

    Venue：Barcelona, Spain   Country：Spain  

  • コイ補体レクチン経路に関連するコレクチンの異物認識多様性

    一木昭土、塚本春香、杣本智軌、中尾実樹

    第47回補体シンポジウム  2010.9 

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    Event date： 2010.9

    Venue：福島市三河南町   Country：Japan  

  • Characterization of zymosan-binding proteins in Nile Tilapia serum

    Soha Gomma, T. Somamoto, M. Nakao

    第22回日本比較免疫学会  2010.8 

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    Event date： 2010.8

    Venue：九州大学   Country：Japan  

  • 魚類における膜型補体制御因子の同定

    辻倉　正和、塚本　春香、杣本智軌、中尾実樹

    第22回日本比較免疫学会  2010.8 

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    Event date： 2010.8

    Venue：九州大学   Country：Japan  

  • FUNCTIONAL ANALYSIS OF CARP COMPLEMENT C3 ISOTYPES USING MONOCLONAL ANTIBODIES International conference

    Satoko Ichiki, Yoko Kato-Unoki, Tomonori Somamoto, and Miki Nakao,

    11th Congress of International Society of Developmental and Comparative Immunology  2009.6 

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    Event date： 2010.6 - 2010.7

    Presentation type：Oral presentation (general)  

    Venue：Prague,Czech Republic   Country：Japan  

  • コイ補体成分 C7 アイソタイプの機能分化

    赤星佐和・辻倉正和・一木智子・杣本智軌・中尾実樹

    日本水産学会春季大会  2010.3 

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    Event date： 2010.3

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイ補体関連血清レクチンアイソタイプの異物認識多様性

    一木昭土・塚本春香・杣本智軌・中尾実樹

    日本水産学会春季大会  2010.3 

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    Event date： 2010.3

    Presentation type：Oral presentation (general)  

    Venue：日本大学   Country：Japan  

  • 魚類C3アイソタイプの生体防御における機能分化

    一木智子、鵜木 (加藤) 陽子、杣本智軌、中尾実樹,

    第46回補体シンポジウム  2009.8 

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    Event date： 2009.8

    Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイC1複合体の亜成分組成

    市居　敬、辻倉正和、杣本智軌、鵜木陽子、加藤愼一、吉国通庸、中尾実樹,

    第46回補体シンポジウム  2009.8 

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    Event date： 2009.8

    Country：Japan  

  • コイ初期発生におけるC3アイソタイプの発現パターン

    Vo Kha Tam、大蔵千恵、杣本智軌、中尾実樹,

    第46回補体シンポジウム  2009.8 

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    Event date： 2009.8

    Country：Japan  

  • コイ補体C1複合体を構築するサブユニットの同定

    市居　敬・辻倉正和・杣本智軌・鵜木陽子・加藤愼一・吉国通庸・中尾実樹,

    日本比較免疫学会  2009.8 

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    Event date： 2009.8

    Venue：日本大学   Country：Japan  

  • MOLECULAR ARCHITECTURE OF C1 COMPLEX, THE FIRST COMPLEMENT COMPONENT, IDENTIFIED FROM THE COMMON CARP International conference

    Takashi Ichii, Tomonori Somamoto, and Miki Nakao,

    11th Congress of International Society of Developmental and Comparative Immunology  2009.6 

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    Event date： 2009.6 - 2009.7

    Presentation type：Oral presentation (general)  

    Venue：Prague,Czech Republic   Country：Japan  

  • 魚類における抗体依存的な補体活性化経路の構成成分

    中尾実樹・杣本智軌・辻倉正和・一木智子

    第12回日本マリンバイオテクノロジー学会  2009.5 

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    Event date： 2009.5

    Country：Japan  

  • コイ血清レクチンMBL, GalBLの構造と機能

    一木昭土・畑中大作・杣本智軌・中尾実樹

    日本水産学会九州支部大会  2009.1 

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    Event date： 2009.1

    Presentation type：Oral presentation (general)  

    Venue：長崎大学   Country：Japan  

  • Molecular Identification of a Novel Regulator of Complement Activation in Teleost Immune System International conference

    Masakazu TSUJIKURA, Tomonori SOMAMOTO, Yoko KATO-UNOKI, and Miki NAKAO

    World Fisheries Congress  2008.10 

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    Event date： 2008.11

    Country：Japan  

  • 魚類における新規補体制御因子の同定

    辻倉正和・杣本智軌・鵜木陽子・中尾実樹

    日本水産学会  2008.3 

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    Event date： 2008.11

    Country：Japan  

  • コイ補体成分C7アイソタイプのクローニングと発現解析

    赤星佐和、辻倉正和、杣本智軌、中尾実樹

    補体シンポジウム  2008.7 

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    Event date： 2008.11

    Country：Japan  

  • コイおよびゼブラフィッシュの膜型補体制御因子

    辻倉正和・杣本智軌・鵜木陽子・中尾実樹

    日本比較免疫学会  2008.8 

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    Event date： 2008.11

    Country：Japan  

  • 補体レクチン経路に関与するコイ血清レクチンの多様性

    一木昭土、畑中大作、杣本智軌、中尾実樹

    日本比較免疫学会  2008.8 

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    Event date： 2008.11

    Country：Japan  

  • Structural and functional diversity of the complement components in bony fish: implication for innate immune defense International conference

    Miki Nakao, Junichi Mutsuro, Yoko Kato-Unoki, and Tomonori Somamoto

    Ｉnternational Conference of Advanced Research on Marine Bioresources  2008.10 

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    Event date： 2008.11

    Country：Japan  

  • The Complement System of Teleost: Isotypic Diversity of Its Components in the Structure, Expression, and Functions. International conference

    Miki NAKAO, Tomonori SOMAMOTO, Yoko KATO-UNOKI, and Junichi MUTSURO

    Ｉnternational Conference of Advanced Research on Marine Bioresources  2008.10 

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    Event date： 2008.11

    Country：Japan  

  • Identification and Expression Analysis of Two Isotypes of Carp Complement Component C7 International conference

    Sawa AKAHOSHI, Tomonori SOMAMOTO, and Miki NAKAO

    World Fisheries Congress  2008.10 

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    Event date： 2008.11

    Country：Japan  

  • Structural and functional diversity of the complement components in bony fish: implication for innate immune defense International conference

    Miki Nakao, Junichi Mutsuro, Yoko Kato-Unoki, and Tomonori Somamoto

    International Conference of Advanced Research on Marine Bioresources  2008.5 

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    Event date： 2008.5

    Country：Japan  

  • コイ補体B因子アイソタイプ遺伝子の構造と発現制御

    岩谷健太郎・杣本智軌・鵜木陽子・中尾実樹

    日本水産学会  2008.3 

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    Event date： 2008.3

    Country：Japan  

  • ギンブナのウイルス感染同系細胞株に対する特異的細胞傷害活性

    杣本智軌,　岡本信明

    日本水産学会秋季大会  1999.9 

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    Presentation type：Oral presentation (general)  

    Venue：宮城教育大学   Country：Japan  

  • Cytotoxic T-cell function in fish. Invited International conference

    T. Nakanishi, U. Fischer, J.M.Dijkststra, B. Kollner, K. Aoyagi, C. Xia, K. Hashimoto, K. Okamura, S. Hasegawa, T. Somamoto, N. Okamoto, and M. Ototake

    8th International Society of Developmental and Comparative Immunology Congress  2000.7 

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    Presentation type：Oral presentation (invited, special)  

    Venue：Cairns   Country：Australia  

  • Cell-mediated cytotoxicity of ginbuna crucian carp after infection with Crucian carp Haematopoietic Necrosis Virus (CHNV). International conference

    Tomonori Somamoto, Teruyuki Nakanishi, Nobuaki Okamoto

    8th International Society of Developmental and Comparative Immunology Congress  2000.7 

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    Presentation type：Oral presentation (general)  

    Venue：Cairns   Country：Australia  

  • ギンブナのCHNV感染に対する特異的細胞傷害活性の役割

    杣本智軌,中西照幸, 岡本信明

    日本魚病学会春季大会  2001.3 

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    Presentation type：Oral presentation (general)  

    Venue：東京水産大学   Country：Japan  

  • ウイルス感染防除における魚類の特異的細胞傷害能の役割

    杣本智軌, 中西照幸, 岡本信明

    第13回　日本比較免疫学会  2001.8 

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    Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  • Specific cytotoxic cells of ginbuna crucian carp are responsible for in vivo clearance of carp haematopoietic necrosis virus (CHNV). International conference

    Nobuaki Okamoto, Tomonori Somamoto, Teruyuki Nakanishi.

    International Commenorative Symposium 70th Anniversary of Japanese Society of Fisheries Science  2001.10 

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    Presentation type：Oral presentation (general)  

    Venue：東京水産大学   Country：Japan  

  • Non-specific immune response of rainbow trout in relation to different dietary status of vitamin E and highly unsaturated fatty acids.

    V. Kiron, J. Paungkaew, T. Somamoto, N. Okamoto, S. Satoh, T. Takeuchi, T. Watanabe.

    日本水産学会大会  2002.4 

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    Presentation type：Oral presentation (general)  

    Venue：東京水産大学   Country：Japan  

  • Antioxidant and nonspecific immune defense of rainbow trout in relation to dietary status of vitamin E and highly unsaturated fatty acids. International conference

    Paungkaew, V. Kiron, T. Somamoto, N. Okamoto, S. Satoh, T. Takeuchi, T. Watanabe.

    10th International Symposium on Nutrition & Feeding in Fish  2002.6 

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    Presentation type：Oral presentation (general)  

    Venue：Rhodes   Country：Greece  

  • MHC class I polymorphism in rainbow trout (Oncorhynchus mykiss): Disease resistance allograft rejection and behavior International conference

    Johannes Martinus Dijkstra, Ikunari Kiryu, Uwe Fischer, Bernd Kollner, Tomonori Somamoto, Teruyuki Nakanishi, Mitsuru Ototake.

    7th International Workshop on MHC Evolution and VIII coplement genetics  2002.10 

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    Presentation type：Oral presentation (general)  

    Venue：Perth   Country：Australia  

  • 温度ストレスを与えた時のニジマス免疫機能に対する飼料中ビタミンC含有効果

    久住真紗哉,　キロン ヴィスワナス、佐藤秀一、岡本信明、杣本智軌

    日本水産学会大会  2003.4 

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    Presentation type：Oral presentation (general)  

    Venue：東京水産大学   Country：Japan  

  • Sytemic priming of alloreactive cytotoxic cells in carp, following anal administration of allogeneic antigens International conference

    Sato Atsushi, Tomonori Somamoto, Hiroyuki Yokooka, Nobuaki Okamoto.

    9th International Society of Developmental and Comparative Immunology Congress,  2003.6 

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    Presentation type：Oral presentation (general)  

    Venue：St Andrews, Scotland   Country：United Kingdom  

  • In vitro generated viral-antigen dependent cytotoxic cells of ginbuna crucian carp International conference

    Tomonori Somamoto, Atsushi Sato, Teruyuki Nakanishi, Mitsuru Ototake, Nobuaki Okamoto

    9th International Society of Developmental and Comparative Immunology Congress,  2003.6 

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    Presentation type：Oral presentation (general)  

    Venue：St Andrews, Scotland   Country：United Kingdom  

  • ギンブナのウイルス抗原特異的細胞傷害性白血球はsIg陰性でTCRβ, CD8α遺伝子を発現する

    杣本智軌、吉浦康寿、岡本信明、中西照幸、乙竹充

    第16回　日本比較免疫学会  2004.8 

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    Presentation type：Oral presentation (general)  

    Venue：琉球大学   Country：Japan  

  • Divesification of complement component isotypes in the common carp:Expression pattern and some functional aspects International conference

    Chie Okura, Kentaro Iwatani, Daisuke Shibata, Yoko Kato-Unoki, Tomonori Somamoto and Miki Nakao

    10th International Society of Developmental and Comparative Immunology Congress  2006.6 

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    Presentation type：Symposium, workshop panel (public)  

    Venue：South Carolina   Country：United States  

  • ギンブナCD8α鎖に対するモノクローナル抗体の特性解明

    小池　拓人、　戸田　秀明、　瀧澤　文雄、　荒木　亨介、　杣本　智軌、　末武　弘章、　鈴木　譲、　乙竹　充、　森友　忠昭、　中西　照幸

    生体防御学会  2006.7 

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    Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイの新奇補体制御因子のcDNAクローニング

    吉田大志、杣本智軌，加藤陽子，中尾実樹

    日本比較免疫学会学術集会  2006.8 

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    Presentation type：Oral presentation (general)  

    Venue：広島   Country：Japan  

  • ゼブラフィッシュ新奇補体制御因子のｃDNAクローニング

    辻倉正和・杣本智軌・加藤陽子・中尾実樹

    日本魚病学会  2006.9 

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    Presentation type：Oral presentation (general)  

    Venue：長崎   Country：Japan  

  • Identification of the genes encoding complement components from the zebrafish genome database International conference

    Miki Shinbara, Vo Kha Tam, Yoko Kato-Unoki, Tomonori Somamoto, and Miki Nakao,

    Asia-Pacific Aquatic Genomics Symposium 2006  2006.11 

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    Country：Japan  

  • 発現パターンから見た魚類補体の生体防御機能の推定

    大蔵千恵、新原美樹、杣本智軌、中尾実樹、近藤昌和,

    南中九州・西四国水族防疫会議  2007.2 

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    Country：Japan  

  • ゼブラフィッシュ補体成分の遺伝子の同定と発現解析

    新原美樹、杣本智軌、Vo Kha Tam、加藤陽子、中尾実樹,

    日本水産学会大会  2007.3 

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    Country：Japan  

  • コイ補体成分C4, C5の組換え体の発現と機能解析

    中尾実樹、加藤陽子、市居　敬、杣本智軌

    日本水産学会大会  2007.3 

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    Country：Japan  

  • コイ補体成分C1タンパク質の同定

    市居　敬、杣本 智軌、鵜木（加藤）陽子、中尾実樹

    補体シンポジウム  2007.8 

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    Country：Japan  

  • モノクローナル抗体を用いたコイC3アイソタイプの機能解析

    一木智子、鵜木（加藤）陽子、杣本智軌、中尾実樹,

    ,補体シンポジウム  2007.8 

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    Country：Japan  

  • 魚類における新規補体制御因子の同定

    辻倉正和、杣本智軌、鵜木（加藤）陽子、中尾実樹,

    補体シンポジウム  2007.8 

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    Country：Japan  

  • コイの個体発生における補体成分アイソタイプの発現解析

    大蔵千恵、杣本智軌，近藤昌和，中尾実樹,

    ,日本比較免疫学会  2007.8 

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    Country：Japan  

  • Identification and expression analysis of a novel interleukine 8 (IL-8)-like CXC chemokine in carp (Cyprinus carpio)

    Nevien K. Abdelkhalek, Asuka Komiya, Yoko Kato-Unoki, Tomonori Somamoto, Miki Nakao

    日本魚病学会  2007.9 

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    Country：Japan  

  • Functional analysis of carp C3 isotypes using monoclonal antibodies International conference

    Satoko Ichiki, Yoko Kato-Unoki, Tomonori Somamoto, and Miki Nakao,

    Japan-Germany International Cooperative Project on Education and Research,  2007.9 

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    Country：Japan  

  • 非定型Aeromonas salmonicida感染症（穴あき病）発症時におけるコイ補体C3タンパク質の体内分布

    前田　佑佳, 杣本智軌, 中尾 実樹

    補体シンポジウム  2013.7 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：旭川医科大学   Country：Japan  

  • 無魚粉飼料が魚類の補体に及ぼす影響

    栁　綾佳, 畑中晃昌, 青木直人, 杣本智軌, 中尾 実樹

    日本水産学会秋季大会  2013.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：三重大学   Country：Japan  

  • 魚類栓球の異物分解・殺菌

    長沢貴宏, Rieger　AM, Barreda　DR, 杣本智軌, 中尾 実樹

    日本水産学会春季大会  2014.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北海道大学　（函館）   Country：Japan  

  • CD46 様コイ補体制御因子（Tecrem）の上皮細胞における表面発現動態

    元部詩織, 辻倉正和, 中村亮太, 杣本 智軌, 中尾 実樹

    第51回補体シンポジウム  2014.8 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイ補体 Properdin アイソフォームの機能解析,日本水産学会春季大会

    吉岡和紀, 鵜木陽子, 杣本 智軌, 中尾 実樹

    日本水産学会春季大会  2015.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

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MISC

  • 魚類の病原体に対する細胞性免疫に関する研究 Reviewed

    杣本智軌

    魚病研究　(Fish Pathology)   2023.12

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • アフィニティーシルクの養殖魚の感染症予防への応用

    杣本智軌, Harsha Prakash, 小島桂,　佐藤充.

    アグリバイオ   2022.9

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 魚類の粘膜を介したワクチン投与法

    杣本 智軌

    アクアネット　（湊文社）   2020.7

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 私の実験動物 #８　ギンブナ Carassius auratus langsforfi

    杣本　智軌

    JADCI News   2020.6

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Mucosal delivery of fish vaccines: Local and systemic immunity following mucosal immunisations Reviewed

    Tomonori Somamoto, Teruyuki Nakanishi

    Fish and Shellfish Immunology   2020.2

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： 10.1016/j.fsi.2020.01.005

    Repository Public URL： http://hdl.handle.net/2324/2555029

  • Cytotoxic activities of fish leucocytes

    Uwe Fischer, Katrin Utke, Tomonori Somamoto, Bernd Köllner, Mitsuru Ototake, Teruyuki Nakanishi

    Fish & Shellfish Immunology   2006.2

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 魚類α1-酸性糖タンパク質（AGP）－その機能と養殖への応用

    大嶋 雄治, 高井 優生, 助田 将樹, 杣本 智軌, 島崎 洋平

    2020.11

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    Language：Japanese  

  • Antiviral functions of CD8(+) cytotoxic T cells in teleost fish

    Tomonori Somamoto, Erling Olaf Koppang, Uwe Fischer

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   2014.4

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    Language：English  

    Cytotoxic T-cells (CTLs) play a pivotal role in eliminating viruses in mammalian adaptive immune system. Many recent studies on T-cell immunity of fish have suggested that teleost CTLs are also important for antiviral immunity. Cellular functional studies using clonal ginbuan crucian carp and rainbow trout have provided in vivo and in vitro evidence that in many respects, virus-specific CTLs of fish have functions similar to those of mammalian CTLs. In addition, mRNA expression profiles of CTL-related molecules, such as CD8, TCR and MHC class I, have shown that in a wide range of fish species, CTLs are involved in antiviral adaptive immunity. These findings are a basis to formulate possible vaccination strategies to trigger effective antiviral CTL responses in teleost fish. This review describes recent advances in our understanding of antiviral CTL functions in teleost fish and discusses vaccination strategies for efficiently inducing CTL activities. (C) 2013 Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.dci.2013.07.014

  • Cytotoxic T cells in teleost fish. Reviewed

    Teruyuki Nakanishi, Hideaki Toda, Yasuhiro Shibasaki, Tomonori Somamoto

    Developmental and comparative immunology   2011.12

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    Language：English  

    The presence of antigen-specific cytotoxic T cells has been suggested in a number of in vivo and in vitro studies in fish. Acute allograft rejection with an accelerated response on second-set grafts and the presence of graft-versus-host reaction (GVHR) has been reported in teleost. Alloantigen- and virus-specific cytotoxicity has also been demonstrated in ex vivo studies in ginbuna and rainbow trout. In addition, alloantigen-specific cytotoxic T cell clones have been produced in cultures initiated with peripheral blood leukocytes (PBL) from an alloantigen-immunized channel catfish. Over the last decade several fish genomes have been sequenced and genetic information is rapidly accumulating. Thanks to these genome data bases and EST analysis, mRNA expression of T cell surface marker genes in alloantigen- or virus-specific effector cells has been reported in some fish species, e.g. TCR α or β and CD8α in ginbuna and rainbow trout, and TCR α, β or γ in channel catfish. These findings suggest the presence of CD8(+) cytotoxic T lymphocyte (CTL) in fish similar to those of higher vertebrates. Recently, monoclonal antibodies against CD8α and CD4 antigens have been produced in some fish species. Investigation on the characteristics of CTL and cell-mediated immune mechanisms is now possible at defined T cell subsets, although identification of T cell subset is limited in a few fish species at present. In this review, we describe the recent progress in this field focusing on cells involved in antigen specific cytotoxicity.

    DOI： 10.1016/j.dci.2011.03.033

  • The complement system in teleost fish: Progress of post-homolog-hunting researches

    Miki Nakao, Masakazu Tsujikura, Satoko Ichiki, Tam K. Vo, Tomonori Somamoto

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   2011.12

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    Language：English  

    Studies on the complement system of bony fish are now finishing a stage of homologue-hunting identification of the components, unveiling existence of almost all the orthologues of mammalian complement components in teleost. Genomic and transcriptomic data for several teleost species have contributed much for the homologue-hunting research progress. Only an exception is identification of orthologues of mammalian complement regulatory proteins and complement receptors. It is of particular interest that teleost complement components often exist as multiple isoforms with possible functional divergence. This review summarizes research progress of teleost complement system following the molecular identification and sequence analysis of the components. The findings of extensive expression analyses of the complement components with special emphasis of their prominent extrahepatic expression, acute-phase response to immunostimulation and various microbial infections, and ontogenic development including maternal transfer are discussed to infer teleost-specific functions of the complement system. Importance of the protein level characterization of the complement components is also emphasized, especially for understanding of the isotypic diversity of the components, a unique feature of teleost complement system. (C) 2011 Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.dci.2011.03.003

  • 魚類における膜型補体制御因子の同定と機能解析：次世代魚病ワクチンアジュバントへの展開に向けて Reviewed

    辻倉正和, 杣本智軌, 鵜木陽子, 中尾実樹

    生物機能研究   2010.11

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    Language：Others  

  • 補体活性化の系統発生

    中尾実樹, 杣本智軌

    2007.7

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    Language：Japanese  

  • Diversified components of bony fish complement system: More genes for robuster innate defense?

    Nakao M, Kato-Unoki Y, Nakahara M, Mutsuro J and Somamoto T,

    Experimental Medicine and Biology   2006.1

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Cytotoxic T cell function in fish. Reviewed

    Nakanishi T, Fischer U, Dijkstra JM, Hasegawa S, Somamoto T, Okamoto N, Ototake M

    Developmental and comparative immunology   2002.3

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    Language：Others  

    Cytotoxic T cell function in fish.

    DOI： 10.1016/S0145-305X(01)00055-6

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Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Japanese Association for Developmental & Comparative Immunology

  • 国際比較免疫学会

  • The Japanese Society of Fisheries Science

  • The Japanese Society of Fish Pathology

Committee Memberships

  • 日本水産学会   シンポジウム委員   Domestic

    2022.4 - 2026.3   

  • 日本水産学会九州支部会   庶務   Domestic

    2020.4 - 2022.3   

  • International Society of Developmental and Comparative Immunology (ISDCI)   Local organizing Committee   Foreign country

    2011.2 - 2012.7   

  • 日本比較免疫学会   Organizer   Domestic

    2007.7 - 2013.3   

Academic Activities

  • 座長

    日本魚病学会春季大会  （ Japan ） 2024.3

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    Type：Competition, symposium, etc. 

  • 学術集会事務局長

    第34回日本比較免疫学会学術集会  （ Japan ） 2023.9

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    Type：Competition, symposium, etc. 

    Number of participants：60

  • Screening of academic papers

    Role(s)： Peer review

    2023

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：7

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • 座長

    日本水産学会秋季大会  （ Japan ） 2022.9

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    Type：Competition, symposium, etc. 

  • 会場

    日本水産学会　九州支部大会  （ Japan ） 2022.1

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2022

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：10

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • 座長

    日本水産学会春季大会  （ Japan ） 2021.3

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    Type：Competition, symposium, etc. 

  • 会場

    日本水産学会九州支部会  （ Japan ） 2021.1

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2021

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：20

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：21

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • Screening of academic papers

    Role(s)： Peer review

    2019

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：8

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • Screening of academic papers

    Role(s)： Peer review

    2018

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • 座長（Chairmanship）

    日本魚病学会  （ Japan ） 2017.9

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本比較免疫学会  （ Japan ） 2017.8

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2017

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：11

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • 司会（Moderator）

    日本魚病学会  （ Japan ） 2014.9

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    Type：Competition, symposium, etc. 

  • 副委員長

    日本魚病学会  （ Japan ） 2014.9

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    Type：Competition, symposium, etc. 

    Number of participants：100

  • プログラム委員

    日本水産学会秋季大会  （ Japan ） 2014.9

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    Type：Competition, symposium, etc. 

    Number of participants：1,000

  • 座長（Chairmanship）

    日本比較免疫学会  （ Japan ） 2014.7

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本比較免疫学会  （ Japan ） 2013.8

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本水産学会春季大会  （ Japan ） 2013.3

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship） International contribution

    International Society of Developmental and Comparative Immunology  （ Japan ） 2012.7

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    Type：Competition, symposium, etc. 

  • LOCAL ORGANIZING COMMITTEE International contribution

    12th Conress of International Society of Developmental and Comparative Immunology  （ Fukuoka Japan ） 2012.7 - 2012.3

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本比較免疫学会  （ Japan ） 2011.8

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本比較免疫学会  （ Japan ） 2010.8

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本比較免疫学会  （ Japan ） 2009.8

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本水産学会  （ Japan ） 2009.3

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本比較免疫学会  （ Japan ） 2008.8 - 2008.11

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    第19回　日本比較免疫学会  （ Japan ） 2007.8

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    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    日本水産学会九州支部シンポジウム  （ Japan ） 2005.9

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    Type：Competition, symposium, etc. 

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Research Projects

  • 「組換えシルクタンパク質を用いた陸上養殖における病原体検出システムの構築 」 研究成果最適展開支援プログラム（A-STEP）産学共同（育成型）

    2023.10 - 2026.3

    　 More details

    Authorship：Principal investigator 

  • 「養殖魚用経口ワクチンの投与技術の開発と評価」　研究開発成果の社会実装への橋渡しプログラム（BRIDGE）, 「動物用食べるワクチン」の開発による感染症対策の強化　(内閣府)

    2023.10 - 2026.3

    　 More details

    Authorship：Coinvestigator(s) 

  • 戦略的養殖品目の研究開発及び評価

    2023.4 - 2024.3

    Research commissions

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Other funds from industry-academia collaboration

  • 「組換えシルクタンパク質を用いた陸上養殖における病原体検出システムの構築 」

    2023 - 2025

    科学技術振興機構（JST） 研究成果最適展開支援プログラム（A-STEP）産学共同（育成型）

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 「動物用食べるワクチン」の開発による感染症対策の強化　 担当課題「養殖魚用経口ワクチンの投与技術の開発と評価」(実行課題責任者）

    2023 - 2025

    研究開発成果の社会実装への橋渡しプログラム（BRIDGE）(内閣府　農林水産省)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Contract research

  • 「地域のバイオマスを利用した省エネ型エビ養殖システム高度化実証研究（ベトナム）/実証研究」における、SOFC等を含むエビ養殖システム及びエビ養殖生産性向上についての調査

    2022.11 - 2025.3

    Research commissions

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Other funds from industry-academia collaboration

  • 魚類感染症を防除する新規デバイスの開発

    2021.4 - 2027.3

    Joint research

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • 多彩な魚類レクチンを利用した新素材「レクチンシルク」の開発およびその応用

    Grant number：21K18225  2021 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Challenging Research(Pioneering)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 魚類のDNAワクチン有効性発揮メカニズムの解明

    Grant number：20H03081  2020 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 粘膜免疫活性化による魚類の記憶T細胞の誘導機構の解明

    Grant number：20H03075  2020 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 補体C3の細胞内活性化による魚類Ｔ細胞の活性化制御と細胞性免疫応答の強化

    Grant number：19H03050  2019 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 魚類リポカリンタンパク質―性分化機構を中心とした機能の解明

    Grant number：18H02280  2019

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • SIP（スマートバイオ産業・農業基盤技術） 昆虫（カイコ等）による有用タンパク質・新高機能素材の製造技術の開発・実用化

    2018.11 - 2020.3

    内閣府 

    　 More details

    Authorship：Coinvestigator(s) 

    カイコで作製したアフィニティーシルクを利用して簡易魚病診断キット・病原体捕集デバイスの製品化を目指す

  • 昆虫（カイコ等）による有用タンパク質・新高機能素材の製造技術の開発・実用化、担当課題：簡易魚病診断キット・病原体捕集デバイスの製品化

    2018 - 2020

    戦略的イノベーション創造プログラム（SIP）（スマートバイオ産業・農業基盤技術）

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • 寄生虫に対する魚類粘膜組織における獲得免疫機構の解明

    Grant number：17K07939  2017 - 2019

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • アフィニティーシルクによる魚病防除に向けた研究

    2016.7 - 2019.3

    Joint research

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • アフィニティーシルクによる観賞魚の病害防除に向けた研究

    2016.7 - 2019.3

    　 More details

    Authorship：Coinvestigator(s) 

  • 簡便かつ鋭敏な細胞性免疫機能測定による水産用ワクチン有効性評価法の開発

    Grant number：16H04984  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 補体のホメオスタシス機能を活用した魚類粘膜の自然免疫バリアの強化

    Grant number：16H04982  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 高効率燃料電池と再生バイオガスを融合させた地域内エネルギー循環システムの構築 International coauthorship

    2015.4 - 2018.3

    　 More details

    Authorship：Coinvestigator(s) 

  • 抗体を利用したニシキゴイの感染症予防法の開発

    2015.3 - 2017.3

    　 More details

    Authorship：Principal investigator 

  • 高効率燃料電池と再生バイオガスを融合させた地域内エネルギー循環システムの構築

    2015 - 2019

    JST-JICA 地球規模課題対応国際科学技術協力プログラム（SATREPS）

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Contract research

  • 研究助成金

    2015

    　 More details

    Grant type：Donation

  • 魚類の粘膜免疫の活性化による獲得免疫誘導機構の解明

    Grant number：26450286  2014 - 2016

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 栓球による魚類免疫応答の活性化と制御の分子機構

    Grant number：25292127  2013 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 魚類インターフェロンの機能解明による魚類疾病予防法の開発

    Grant number：25292129  2013 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 穴あき病原菌（Aeromonous Salmonicida)とコイヘルペスウイルス(KHV)に対する鶏卵抗体の作製

    2012.6 - 2013.5

    Research commissions

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • 鶏卵抗体を利用したニシキゴイ感染症に対する新しい感染予防法の開発

    2011.6 - 2012.6

    Research commissions

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • コイヘルペスウイルスおよび穴あき病原菌の抗原作製

    2010.4 - 2011.3

    Research commissions

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • 魚類における補体活性化制御因子のを活用した免疫応答の最適化

    2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 魚類の獲得免疫系における細胞性免疫と液性免疫のウイルス感染防御効果

    Grant number：22780176  2010 - 2012

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 魚類免疫応答におけるT細胞機能の解明による魚類疾病の診断・予防法の開発

    Grant number：21380126  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 抗コイヘルペスウイルス(KHV)鶏卵抗体の受動免疫効果の検証

    2008.10 - 2010.10

    Joint research

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • 免疫関連遺伝子発現プロファイルを用いた魚類ウイルス性疾病の診断・予防法の開発

    2006 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 多様化した魚類補体成分アイソタイプが構築する補体活性化ネットワークの解明

    Grant number：18380117  2006 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 魚類におけるウイルス抗原特異的リンパ球の培養システムの構築

    Grant number：18780148  2006 - 2008

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 幅広い魚種で機能する補体マスターキー分子の作出

    Grant number：17658089  2005 - 2006

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Exploratory Research

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 魚類のウイルス抗原特異的細胞傷害能に関する研究

    Grant number：03J02019  2003 - 2004

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

▼display all

Class subject

  • 水族生化学実験

    2024.4 - 2024.9   First semester

  • 水産科学のフロンティア

    2024.4 - 2024.9   First semester

  • 生命の科学Ａ

    2023.12 - 2024.2   Winter quarter

  • 比較免疫学特論

    2023.12 - 2024.2   Winter quarter

  • 動物生産科学概論

    2023.10 - 2024.3   Second semester

  • 生物機能分子化学特別研究第二

    2023.10 - 2024.3   Second semester

  • 生命の科学Ａ

    2023.10 - 2023.12   Fall quarter

  • 魚類免疫学II

    2023.6 - 2023.8   Summer quarter

  • 実地見学（水産科学分野）

    2023.4 - 2024.3   Full year

  • Animal and Marine Life Science

    2023.4 - 2023.9   First semester

  • 生物機能分子化学特別研究第一

    2023.4 - 2023.9   First semester

  • 生物機能分子化学プロジェクト演習

    2023.4 - 2023.9   First semester

  • 生物機能分子化学特論II

    2023.4 - 2023.9   First semester

  • 魚類免疫学Ⅰ

    2023.4 - 2023.6   Spring quarter

  • Master's Thesis Research Ⅱ

    2023.4 - 2023.6   Spring quarter

  • 比較免疫学特論

    2022.12 - 2023.2   Winter quarter

  • 生命の科学Ａ

    2022.12 - 2023.2   Winter quarter

  • 生物機能分子化学特別研究第二

    2022.10 - 2023.3   Second semester

  • 動物生産科学概論

    2022.10 - 2023.3   Second semester

  • 生命の科学Ａ

    2022.10 - 2022.12   Fall quarter

  • 魚類免疫学Ⅱ

    2022.6 - 2022.8   Summer quarter

  • 水産科学のフロンティア

    2022.4 - 2022.9   First semester

  • 水族生化学実験

    2022.4 - 2022.9   First semester

  • Animal and Marine Life Science

    2022.4 - 2022.9   First semester

  • 生物機能分子化学プロジェクト演習

    2022.4 - 2022.9   First semester

  • 生物機能分子化学特論II

    2022.4 - 2022.9   First semester

  • 生物機能分子化学特別研究第一

    2022.4 - 2022.9   First semester

  • 想定外問題解決型プロジェクト演習　Advanced Problem Based Learning

    2022.4 - 2022.9   First semester

  • 魚類免疫学Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 比較免疫学特論

    2021.12 - 2022.2   Winter quarter

  • 生命の科学Ａ

    2021.12 - 2022.2   Winter quarter

  • 生物機能分子化学特別研究第二

    2021.10 - 2022.3   Second semester

  • 動物生産科学概論

    2021.10 - 2022.3   Second semester

  • 生命の科学Ａ

    2021.10 - 2021.12   Fall quarter

  • 生物化学実験

    2021.4 - 2021.9   First semester

  • 生物機能分子化学特別研究第一

    2021.4 - 2021.9   First semester

  • 生物機能分子化学特論I

    2021.4 - 2021.9   First semester

  • 生物機能分子化学プロジェクト演習

    2021.4 - 2021.9   First semester

  • Animal and Marine Life Science

    2021.4 - 2021.9   First semester

  • 魚類免疫学

    2021.4 - 2021.9   First semester

  • 比較免疫学特論

    2020.12 - 2021.2   Winter quarter

  • 生命の科学Ａ

    2020.12 - 2021.2   Winter quarter

  • 生物機能分子化学特別研究第二

    2020.10 - 2021.3   Second semester

  • 動物生産科学概論

    2020.10 - 2021.3   Second semester

  • 生命の科学Ａ

    2020.10 - 2020.12   Fall quarter

  • 生物化学実験

    2020.4 - 2020.9   First semester

  • 生物機能分子化学特別研究第一

    2020.4 - 2020.9   First semester

  • 生物機能分子化学プロジェクト演習

    2020.4 - 2020.9   First semester

  • 生物機能分子化学特論II

    2020.4 - 2020.9   First semester

  • Animal and Marine Life Science

    2020.4 - 2020.9   First semester

  • 魚類免疫学

    2020.4 - 2020.9   First semester

  • 比較免疫学特論

    2019.10 - 2020.3   Second semester

  • 生物機能分子化学特別研究第二

    2019.10 - 2020.3   Second semester

  • 生命の科学A（秋）

    2019.10 - 2020.3   Second semester

  • 生命の科学A（冬）

    2019.10 - 2020.3   Second semester

  • 生物機能分子化学特論I

    2019.4 - 2019.9   First semester

  • 生物化学実験

    2019.4 - 2019.9   First semester

  • 生物機能分子化学特別研究第一

    2019.4 - 2019.9   First semester

  • 生物機能分子化学プロジェクト演習

    2019.4 - 2019.9   First semester

  • Animal and Marine Life Science

    2019.4 - 2019.9   First semester

  • 動物生産科学概論

    2019.4 - 2019.9   First semester

  • 魚類免疫学

    2019.4 - 2019.9   First semester

  • 生物機能分子化学特別研究第二

    2018.10 - 2019.3   Second semester

  • 比較免疫学特論

    2018.10 - 2019.3   Second semester

  • 水産科指導法Ⅱ

    2018.10 - 2019.3   Second semester

  • 生命の科学A（冬）

    2018.10 - 2019.3   Second semester

  • 生命の科学A（秋）

    2018.10 - 2019.3   Second semester

  • 生物機能分子化学特論II

    2018.4 - 2018.9   First semester

  • 生物化学実験

    2018.4 - 2018.9   First semester

  • 生物機能分子化学特別研究第一

    2018.4 - 2018.9   First semester

  • 生物機能分子化学プロジェクト演習

    2018.4 - 2018.9   First semester

  • Animal and Marine Life Science

    2018.4 - 2018.9   First semester

  • 動物生産科学概論

    2018.4 - 2018.9   First semester

  • 魚類免疫学

    2018.4 - 2018.9   First semester

  • 生命の科学A（前半）

    2017.10 - 2018.3   Second semester

  • 実地見学

    2017.10 - 2018.3   Second semester

  • 生物機能分子化学特別研究第二

    2017.10 - 2018.3   Second semester

  • 生命の科学A（後半）

    2017.10 - 2018.3   Second semester

  • 魚類免疫学

    2017.4 - 2017.9   First semester

  • 生物機能分子化学特別研究第一

    2017.4 - 2017.9   First semester

  • Animal and Marine Life Science

    2017.4 - 2017.9   First semester

  • 分子細胞生物化学特論

    2017.4 - 2017.9   First semester

  • 生物機能分子化学プロジェクト演習

    2017.4 - 2017.9   First semester

  • 動物生産科学概論

    2017.4 - 2017.9   First semester

  • 生物化学実験

    2017.4 - 2017.9   First semester

  • 比較免疫学特論

    2016.10 - 2017.3   Second semester

  • 動物生産科学概論

    2016.10 - 2017.3   Second semester

  • 生命の科学A（前半）

    2016.10 - 2017.3   Second semester

  • 生命の科学A（後半）

    2016.10 - 2017.3   Second semester

  • 卒業研究

    2016.4 - 2017.3   Full year

  • 魚類免疫学

    2016.4 - 2016.9   First semester

  • 生物化学実験

    2016.4 - 2016.9   First semester

  • 生物機能分子化学プロジェクト演習

    2016.4 - 2016.9   First semester

  • 分子細胞生物化学特論

    2016.4 - 2016.9   First semester

  • Animal and Marine Life Science

    2016.4 - 2016.9   First semester

  • 生命の科学A（前半）

    2015.10 - 2016.3   Second semester

  • 比較免疫学特論

    2015.10 - 2016.3   Second semester

  • 基礎化学実験

    2015.10 - 2016.3   Second semester

  • 動物生産科学概論

    2015.10 - 2016.3   Second semester

  • 生命の科学A（後半）

    2015.10 - 2016.3   Second semester

  • 魚類免疫学

    2015.4 - 2015.9   First semester

  • 生物機能分子化学プロジェクト演習

    2015.4 - 2015.9   First semester

  • 分子細胞生物化学特論

    2015.4 - 2015.9   First semester

  • 生物化学実験

    2015.4 - 2015.9   First semester

  • Animal and Marine Life Science

    2015.4 - 2015.9   First semester

  • 比較免疫学特論

    2014.10 - 2015.3   Second semester

  • 生命の科学A（後半）

    2014.10 - 2015.3   Second semester

  • 生命の科学A（前半）

    2014.10 - 2015.3   Second semester

  • 動物生産科学概論

    2014.10 - 2015.3   Second semester

  • 基礎化学実験

    2014.10 - 2015.3   Second semester

  • 卒業研究

    2014.4 - 2015.3   Full year

  • 魚類免疫学

    2014.4 - 2014.9   First semester

  • 基礎化学B

    2014.4 - 2014.9   First semester

  • 分子細胞生物化学特論

    2014.4 - 2014.9   First semester

  • 生物化学実験

    2014.4 - 2014.9   First semester

  • Animal and Marine Life Science

    2014.4 - 2014.9   First semester

  • 生物機能分子化学プロジェクト演習

    2014.4 - 2014.9   First semester

  • 基礎化学実験

    2013.10 - 2014.3   Second semester

  • 科学英語I

    2013.10 - 2014.3   Second semester

  • 動物生産科学概論

    2013.10 - 2014.3   Second semester

  • 卒業研究

    2013.4 - 2014.3   Full year

  • 魚類免疫学

    2013.4 - 2013.9   First semester

  • 生物機能分子化学プロジェクト演習

    2013.4 - 2013.9   First semester

  • Animal and Marine Life Science

    2013.4 - 2013.9   First semester

  • 生物化学実験

    2013.4 - 2013.9   First semester

  • 分子細胞生物化学特論

    2013.4 - 2013.9   First semester

  • 比較免疫学特論

    2013.4 - 2013.9   First semester

  • 基礎化学実験

    2012.10 - 2013.3   Second semester

  • 比較免疫学特論

    2012.10 - 2013.3   Second semester

  • 動物生産科学概論

    2012.10 - 2013.3   Second semester

  • 海洋生命化学特別研究第一

    2012.4 - 2013.3   Full year

  • 海洋生命化学特別研究第二

    2012.4 - 2013.3   Full year

  • 分子細胞生物化学特論

    2012.4 - 2012.9   First semester

  • 魚類免疫学

    2012.4 - 2012.9   First semester

  • 生物化学実験

    2012.4 - 2012.9   First semester

  • 動物生産科学概論

    2011.10 - 2012.3   Second semester

  • 基礎化学実験

    2011.10 - 2012.3   Second semester

  • 海洋生命化学特別研究第二

    2011.4 - 2012.3   Full year

  • 海洋生命化学特別研究第一

    2011.4 - 2012.3   Full year

  • 比較免疫学特論

    2011.4 - 2011.9   First semester

  • 分子細胞生物化学特論

    2011.4 - 2011.9   First semester

  • 生物化学実験

    2011.4 - 2011.9   First semester

  • 基礎化学B

    2011.4 - 2011.9   First semester

  • 魚類免疫学

    2011.4 - 2011.9   First semester

  • Bioscience and Biotechnology

    2011.4 - 2011.9   First semester

  • 基礎化学実験

    2010.10 - 2011.3   Second semester

  • 動物生産科学概論

    2010.10 - 2011.3   Second semester

  • 海洋生命化学特別研究第一

    2010.4 - 2011.3   Full year

  • 魚類免疫学

    2010.4 - 2010.9   First semester

  • 生物化学実験第一

    2010.4 - 2010.9   First semester

  • コアセミナー

    2010.4 - 2010.9   First semester

  • Bioscience and Biotechnology

    2010.4 - 2010.9   First semester

  • 比較免疫学特論

    2010.4 - 2010.9   First semester

  • 科学英語　I

    2009.10 - 2010.3   Second semester

  • 動物生産科学概論

    2009.10 - 2010.3   Second semester

  • 海洋生命化学特別研究第一

    2009.4 - 2010.3   Full year

  • 海洋生命化学特別研究第二

    2009.4 - 2010.3   Full year

  • 生物化学実験

    2009.4 - 2009.9   First semester

  • Bioscience and Biotechnology

    2009.4 - 2009.9   First semester

  • 基礎化学B

    2009.4 - 2009.9   First semester

  • 魚類免疫学

    2009.4 - 2009.9   First semester

  • 基礎化学実験

    2008.10 - 2009.3   Second semester

  • 動物生産科学概論

    2008.10 - 2009.3   Second semester

  • 海洋生命化学特別研究第二

    2008.4 - 2009.3   Full year

  • 海洋生命化学演習第二

    2008.4 - 2009.3   Full year

  • 海洋生命化学演習第一

    2008.4 - 2009.3   Full year

  • 海洋生命化学特別研究第二

    2008.4 - 2009.3   Full year

  • 生物化学実験第一

    2008.4 - 2008.9   First semester

  • Bioscience and Biotechnology

    2008.4 - 2008.9   First semester

  • 基礎化学実験

    2007.10 - 2008.3   Second semester

  • 生物化学実験第一

    2007.4 - 2007.9   First semester

  • 基礎化学実験

    2006.10 - 2007.3   Second semester

  • 生物化学実験第一

    2006.4 - 2006.9   First semester

  • コアセミナー

    2006.4 - 2006.9   First semester

▼display all

FD Participation

  • 2022.3   Role：Participation   Title：国費特別プログラム「未来の農を描くビジョンデザイン実践プログラム」実施に向けて

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.1   Role：Participation   Title：ジャーナルをめぐる現状と今後に向けてー論文の出版と入手ー

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2013.7   Role：Participation   Title：基幹教育と基幹教育カリキュラム

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2012.11   Role：Participation   Title：JSPSグローバル人材育成推進事業（特色型） ”国際的視野を持ったアグリバイオリーダーの育成” 事業について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2012.3   Role：Participation   Title：農学部国際コースの専攻教育について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2011.8   Role：Participation   Title：科研費獲得に向けて

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2010.2   Role：Participation   Title：管理下に無い放射性同位元素等に関する一斉点検の実施について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2009.3   Role：Participation   Title：英語による授業の質の向上を目指して

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2008.12   Role：Participation   Title：生物資源環境科学府の組織再編

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2008.6   Role：Participation   Title：セクシュアル・ハラスメント、アカデミック・ハラスメ ント及び男女共同参画

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2006.5   Role：Participation   Title：学生指導について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2006.3   Role：Participation   Title：ＧＰＡ制度について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2005.5   Role：Participation   Title：学生指導について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2005.2   Role：Participation   Title：農林水産研究基本計画について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2023  東京大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：9月7-8日

  • 2021  東京大学  Classification:Intensive course  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：8月10～11日

Participation in international educational events, etc.

  • 2022.10

    Department of Resource Management of Fisheries and Marine Faculty of Fisheries and Marine Science Universitas Brawijaya

    Teaching Collaboration on Fish Health Management

    　 More details

    Venue：オンラインでの参加　主催地　 Indonesia

Other educational activity and Special note

  • 2011  Class Teacher  学部

  • 2009  Class Teacher  学部

Social Activities

  • 九州大学農学水産科学分野の魅力

    佐賀県立唐津東中学校  2019.11

    　More details

    Audience：Infants,　Schoolchildren,　Junior students,　High school students

    Type：Other

  • 第44回全日本総合錦鯉品評会における新型穴あき病に対する予防技術の紹介

    （株）　キョーリン  東京流通センター　第一展示場   2013.2

    　More details

    Audience：General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Other

  • 第43回全日本総合錦鯉品評会における新型穴あき病に対する予防技術の紹介

    （株）　キョーリン  東京流通センター　第一展示場  2012.2

    　More details

    Audience：General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Other

Activities contributing to policy formation, academic promotion, etc.

  • 2023.4 - 2025.3   厚生労働省

    水産用医薬品調査会　薬事・食品衛生審議会委員.

  • 2021.2 - 2023.2   厚生労働省

    水産用医薬品調査会　薬事・食品衛生審議会委員.

  • 2019.3   佐賀県　有明水産振興センター

    技術指導講演

Acceptance of Foreign Researchers, etc.

  • Can Tho University

    Acceptance period： 2015.12   （Period）：Less than 2 weeks

    Nationality：Viet Nam

  • Acceptance period： 2013.9 - 2014.3  

    Nationality：Egypt

Travel Abroad

  • 2019.10

    Staying countory name 1：Viet Nam   Staying institution name 1：カントー大学

  • 2008.3

    Staying countory name 1：Germany   Staying institution name 1：フリードリッヒ　レフラー研究所