KUMAZOE MOTOFUMI
Organization
Faculty of Agriculture Department of Bioscience and Biotechnology Assistant Professor
Title
Assistant Professor
Contact information
Tel
0928024747
Profile
Most of my research focuses on the role of cGMP in the beneficial effects of phytochemicals.
Our group also identified several molecules including Tollip and demonstrated that those signaling pathway-induced by cGMP play crucial role in the resilience of the human body.
Homepage
External link
ORCID
Research Interests・Research Keywords
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Research theme：My research focuses on the role of cGMP in the physiological effects of phytochemicals. Our group previously identified several molecules including Tollip and demonstrated that those signaling pathways-induced by cGMP play crucial role in the resilience of the human body. To understand the physiological role of the cGMP in the beneficial effect of several compounds including phytochemicals, we use several disease mouse models including orthotopic tumor implantation model (Osteosarcoma, MPM, Pancreatic cancer, Lung cancer, breast cancer, etc) and other disease models (Obesity, SLE, IBD, ARDS, IgAN, NASH, PAH, Parkinson’s disease, Rheumatoid arthritis). Based on our findings, our recent clinical study found that GT-gH (our proposed polyphenols combination based by cGMP induction) suppressed weight gain and BMI increase in human subjects (UMIN000040109 Placebo-controlled, randomized, double-blind). My goal is to establish the novel strategy to prevent and treat the difficult diseases.
Keyword：cGMP, Phytochemicals, Chemical biology, Immunology, Oncology
Research period： 2021.12 - 2022.6
Awards
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令和3年度日本農芸化学会西日本支部奨励賞
2022.1 日本農芸化学会西日本支部 緑茶カテキンEGCGのcGMPを介した生体調節作用
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日本農芸化学会 トピックス賞
2021.3 日本農芸化学会 植物マイクロRNAの肺線維化抑制作用
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がん研究助成奨励金
2018.3 日本対がん協会 cGMPによる癌幹細胞抑制機構の解明
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日本農芸化学会トピックス賞
2017.3 日本農芸化学会 新規膵臓がん幹細胞制御分子の同定
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ネスレ栄養科学学会（NNCJ）2014 年度論文賞
2014.11 Nestlé Nutrition Council Japan 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis
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平成25年度 生物資源環境科学府賞
2014.3 九州大学大学院生物資源環境科学府 緑茶ポリフェノールEpigallocatechin-3-ο-gallateによるがん細胞特異的な細胞致死誘導機構に関する研究
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育志賞
2014.2 日本学術振興会 緑茶ポリフェノールEpigallocatechin-gallateによるがん細胞特異的な細胞致死誘導機構の解明
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平成25年度日本農芸化学会西日本支部奨励賞 (学生)
2014.1 日本農芸化学会西日本支部 緑茶カテキンレセプター67-kDa Laminin Receptorが引き起こす癌細胞致死経路の発見とその増強
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日本農芸化学会 トピックス賞
2013.3 日本農芸化学会 蛍光プローブ化緑茶カテキン EGCG を用いたがん細胞の特異的可視化
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平成24年度日本栄養・食糧学会 九州・沖縄支部 優秀発表者賞
2012.9 日本栄養・食糧学会 九州・沖縄支部大会 Epigallocatechin-3-O-gallate(EGCG)によって活性化されるアポトーシス誘導経路の発見
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9. The 4th International Conference on O-CHA (Tea) Culture and Science Symposium Poster Award.
2010.10 ICOS
Papers
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miR-12135 ameliorates liver fibrosis accompanied with downregulation of ITGA11. Reviewed International journal
Kumazoe Motofumi, Miyamoto Emi, Oka Chihiro, Kondo Miyuki, Yoshitomi Ren, Onda Hiroaki, Shimada Yu, Fujimura Yoshinori, Tachibana Hirofumi.
iScience 108730 2023.12
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PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer. Reviewed International journal
Yamashita Mai*, Kumazoe Motofumi* (Equal Contribution), Onda Hiroaki, Hiroi Shun, Shimada Yu, Fujimura Yoshinori, Tachibana Hirofumi.
Biochem Biophys Res Commun. 672 154 - 160 2023.9
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Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1. Reviewed International journal
Kumazoe Motofumi, Ogawa Fumiyo, Hikida Ai, Shimada Yu, Yoshitomi Ren, Watanabe Ryoya, Onda Hiroaki, Fujimura Yoshinori, Tachibana Hirofumi.
Sci Rep 2128 2023.2
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Fustin, a Flavanonol, Synergically Potentiates the Anticancer Effect of Green Tea Catechin Epigallocatechin-3-O-Gallate with Activation of the eNOS/cGMP Axis. International journal
Kumazoe Motofumi, Fujimura Yoshinori, Yoshitomi Ren, Shimada Yu, Tachibana Hirofumi.
Journal of agricultural and food chemistry 70 ( 11 ) 3458 - 3466 2022.3
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Methylated (-)-epigallocatechin 3-O-gallate potentiates the effect of split vaccine accompanied with upregulation of Toll-like receptor 5. International journal
Kumazoe Motofumi, Takamatsu Kanako, Horie Fuyumi, Yoshitomi Ren, Hamagami Hiroki, Tanaka Hiroshi, Fujimura Yoshinori, Tachibana Hirofumi.
Scientific reports 11 ( 1 ) 23101 - 23101 2021.11
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Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG.
Kumazoe Motofumi, Tanaka Yasutake, Yoshitomi Ren, Marugame Yuki, Lee Kwan-Woo, Onda Hiroaki, Fujimura Yoshinori , Yonekura Madoka, Shimamoto Yasuyo, Tachibana Hirofumi.
Journal of natural medicines 75 ( 4 ) 1037 - 1042 2021.9
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Time-dependent increase of plasma cGMP concentration followed by oral EGCG administration in mice. Invited Reviewed International journal
Tanaka Yasutake*, Kumazoe Motofumi* (Equal Contribution), Onda Hiroaki, Fujimura Yoshinori, Tachibana Hirofumi.
Food Bioscience 41 101017 - 101017 2021.6
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Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation. International journal
Kumazoe Motofumi, Kadomatsu Mai, Bae Jaehoon, Otsuka Yushi, Fujimura Yoshinori, Tachibana Hirofumi.
Molecules (Basel, Switzerland) 25 ( 22 ) 2020.11
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Cancer cell selective probe by mimicking EGCG. Reviewed International journal
Kumazoe Motofumi, Hiroi Shun, Tanimoto Yousuke, Miyakawa Jyunichi, Yamanouchi Maasa, Suemasu Yumi, Yoshitomi Ren, Murata Motoki, Fujimura Yoshinori, Takahashi Takashi, Tanaka Hiroshi, Tachibana Hirofumi.
Biochemical and biophysical research communications 525 ( 4 ) 974 - 981 2020.5
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Epigallocatechin-3-O-gallate induces acid sphingomyelinase activation through activation of phospholipase C. International journal
Bae Jaehoon*, Kumazoe Motofumi* (Equal Contribution), Takeuchi Chieri, Hidaka Shiori, Fujimura Yoshinori, Tachibana Hirofumi.
Biochemical and biophysical research communications 520 ( 1 ) 186 - 191 2019.11
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Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression. Reviewed
Kumazoe Motofumi, Yamashita Mai, Nakamura Yuki, Takamatsu Kanako, Bae Jaehoon, Yamashita Shuya, Yamada Shuhei, Onda Hiroaki, Nojiri Takashi, Kangawa Kenji, Tachibana Hirofumi.
JOURNAL OF IMMUNOLOGY 199 ( 9 ) 3261 - 3269 2017.11
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SphK1 inhibitor potentiates the anti-cancer effect of EGCG on leukaemia cells. Reviewed
Tsukamoto Shuntaro*, Kumazoe Motofumi* (Equal Contribution), Huang Yuhui, Lesnick Connie, Kay E. Neil, Shanafelt D. Tait, Tachibana Hirofumi.
BRITISH JOURNAL OF HAEMATOLOGY 178 ( 1 ) 155 - 158 2017.7
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The FOXO3/PGC-1 beta signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. Reviewed
Kumazoe Motofumi, Takai Mika, Hiroi Shun, Takeuchi Chieri, Kadomatsu Mai, Nojiri Takashi, Onda Hiroaki, Bae Jaehoon, Huang Yuhui, Takamatsu Kanako, Yamashita Shuya, Kangawa Kenji, Tachibana Hirofumi.
JOURNAL OF BIOLOGICAL CHEMISTRY 292 ( 26 ) 10813 - 10823 2017.6
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FOXO3 is essential for CD44 expression in pancreatic cancer cells. Reviewed International journal
Kumazoe Motofumi, Takai Mika, Bae Jaehoon, Hiroi Shun, Huang Yuhui, Takamatsu Kanako, Won Yeong Seon, Yamashita Mai, Hidaka Shiori, Yamashita Shuya, Yamada Shuhei, Murata Motoki, Tsukamoto Shuntaro, Tachibana Hirofumi.
ONCOGENE 36 ( 19 ) 2643 - 2654 2017.5
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PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma. Reviewed
Kumazoe Motofumi, Takai Mika, Hiroi Shun, Takeuchi Chieri, Yamanouchi Maasa, Nojiri Takashi, Onda Hiroaki, Bae Jaehoon, Huang Yuhui, Takamatsu Kanako, Yamashita Shuya, Yamada Shuhei, Kangawa Kenji, Takahashi Takashi, Tanaka Hiroshi, Tachibana Hirofumi.
SCIENTIFIC REPORTS 7 ( 1 ) 1917 2017.5
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Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216. Reviewed
Kumazoe Motofumi, Nakamura Yuki, Yamashita Mai, Suzuki Takashi, Takamatsu Kanako, Huang Yuhui, Bae Jaehoon, Yamashita Shuya, Murata Motoki, Yamada Shuhei, Shinoda Yuki, Yamaguchi Wataru, Toyoda Yui, Tachibana Hirofumi.
JOURNAL OF BIOLOGICAL CHEMISTRY 292 ( 10 ) 4077 - 4088 2017.3
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Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells. Reviewed
Huang Yuhui*, Kumazoe Motofumi* (Equal Contribution), Bae Jaehoon, Yamada Shuhei, Takai Mika, Hidaka Shiori, Yamashita Shuya, Kim Yoonhee, Won Yeongseon, Murata Motoki, Tsukamoto Shuntaro, Tachibana Hirofumi.
ONCOLOGY REPORTS 34 ( 3 ) 1162 - 1168 2015.9
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Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells. Reviewed
Kumazoe Motofumi, Fujimura Yoshinori, Hidaka Shiori, Kim Yoonhee, Murayama Kanako, Takai Mika, Huang Yuhui , Yamashita Shuya, Murata Motoki, Miura Daisuke, Wariishi Hiroyuki, Maeda-Yamamoto Mari, Tachibana Hirofumi.
SCIENTIFIC REPORTS 5 2015.3
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Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells. Reviewed
Kumazoe Motofumi, Tsukamoto Shuntaro, Lesnick Connie, Kay E. Neil, Yamada Koji, Shanafelt D. Tait, Tachibana Hirofumi.
BRITISH JOURNAL OF HAEMATOLOGY 168 ( 4 ) 610 - 613 2015.2
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Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis. Reviewed
Kumazoe Motofumi, Kim Yoonhee, Bae Jaehoon, Takai Mika, Murata Motoki, Suemasu Yumi, Sugihara Kaori, Yamashita Shuya, Tsukamoto Shuntaro, Huang Yuhui, Nakahara Kanami, Yamada Koji, Tachibana Hirofumi.
FEBS LETTERS 587 ( 18 ) 3052 - 3057 2013.9
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67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. Reviewed
Kumazoe Motofumi, Sugihara Kaori, Tsukamoto Shuntaro, Huang Yuhui, Tsurudome Yukari, Suzuki Takashi, Suemasu Yumi, Ueda Naoki, Yamashita Shuya, Kim Yoonhee, Yamada Koji, Tachibana Hirofumi.
JOURNAL OF CLINICAL INVESTIGATION 123 ( 2 ) 787 - 799 2013.2
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Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway. Reviewed International journal
Shimada Yu, Kumazoe Motofumi, Otsuka Yushi, Rin Tetsuzen, Fujimura Yoshinori, Tachibana Hirofumi.
J Nat Med. 2023.12
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Regulatory effect of Epigallocatechin-3-O-gallate on circular RNA expression in mouse liver. Reviewed International journal
Yoshitomi Ren, Kumazoe Motofumi, Lee Kwan Woo, Marugame Yuki, Fujimura Yoshinori, Tachibana Hirofumi.
J Nutr Biochem. 124 109506 2023.10
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The anti-cancer effect of epigallocatechin-3-O-gallate against multiple myeloma cells is potentiated by 5,7-dimethoxyflavone. Reviewed International journal
Bae Jaehoon, Kumazoe Motofumi, Park Su-Jin, Fujimura Yoshinori, Tachibana Hirofumi.
FEBS Open Bio. 13 2147 - 2156 2023.9
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Dextran sulfate sodium-induced mild chronic colitis induced cognitive impairment accompanied by inhibition of neuronal maturation in adolescent mice. Reviewed International journal
Lee Kwanwoo, Kumazoe Motofumi, Marugame Yuki, Fujimura Yoshinori, Tachibana Hirofumi.
Biochem Biophys Res Commun. 669 46 - 53 2023.8
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67-kDa laminin receptor mediates oolonghomobisflavan B-induced cell growth inhibition in melanoma. Reviewed International journal
Bae Jaehoon, Kumazoe Motofumi, Lee Kwan-Woo, Fujimura Yoshinori, Tachibana Hirofumi.
Phytomedicine 118 ( 154970 ) 2023.7
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Myricetin improves cognitive function in SAMP8 mice and upregulates brain-derived neurotrophic factor and nerve growth factor. International journal
Shimada Yu, Sato Yuka, Kumazoe Motofumi, Kitamura Ryo, Fujimura Yoshinori, Tachibana Hirofumi.
Biochemical and biophysical research communications 616 33 - 40 2022.8
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Metabolic Profiling for Evaluating the Dipeptidyl Peptidase-IV Inhibitory Potency of Diverse Green Tea Cultivars and Determining Bioactivity-Related Ingredients and Combinations. International journal
Fujimura Yoshinori, Watanabe Mototsugu, Morikawa-Ichinose Tomomi, Fujino Konatsu, Yamamoto Mao, Nishioka Seita, Inoue Chihiro, Ogawa Fumiyo, Yonekura Madoka, Nakasone Akari, Kumazoe Motofumi, Tachibana Hirofumi.
Journal of agricultural and food chemistry 70 ( 21 ) 6455 - 6466 2022.6
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Sesame lignans upregulate glutathione S-transferase expression and downregulate microRNA-669c-3p. Invited Reviewed International journal
Marugame Yuki, Takeshita Natsuko, Yamada Shuhei, Yoshitomi Ren, Kumazoe Motofumi, Fujimura Yoshinori, Tachibana Hirofumi.
Bioscience of Microbiota, Food and Health 41 ( 2 ) 66 - 72 2022.6
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Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner. International journal
Yamashita Shuya, Lin Ichian, Oka Chihiro, Kumazoe Motofumi, Komatsu Satomi, Murata Motoki, Kamachi Shoko, Tachibana Hirofumi.
The Journal of nutritional biochemistry 100 108910 - 108910 2022.2
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The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial. International journal
11 ( 1 ) 19067 - 19067 2021.9
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Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of O-Methylated Catechin. International journal
Fujimura Yoshinori, Fujino Konatsu, Yoshimoto Takanori, Nezu Ayaka, Marugame Yuki, Bae Jaehoon, Kumazoe Motofumi, Tachibana Hirofumi.
Journal of natural products 84 ( 6 ) 1823 - 1830 2021.6
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Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3. Reviewed International journal
Yoshitomi Ren, Nakayama Kai, Yamashita Shuya, Kumazoe Motofumi, Lin Ting-An, Mei Chen-Yi, Marugame Yuki, Fujimura Yoshinori, Maeda-Yamamoto Mari, Kuriyama Shinichi, Tachibana Hirofumi.
Scientific Reports 10 ( 1 ) 10283 - 10283 2020.12
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EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol. Reviewed
Murata Motoki, Shimizu Yuki, Marugame Yuki, Nezu Ayaka, Fujino Konatsu, Yamada Shuhei, Kumazoe Motofumi, Fujimura Yoshinori, Tachibana Hirofumi.
Journal of natural medicines 2020.5
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Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67-kDa Laminin Receptor Signaling. International journal
Bae Jaehoon, Kumazoe Motofumi, Murata Kyosuke, Fujimura Yoshinori, Tachibana Hirofumi.
Molecular nutrition & food research 64 ( 7 ) e1900986 2020.4
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Alteration of specific cytokine expression patterns in patients with breast cancer. International journal
Kawaguchi Kosuke, Sakurai Masashi, Yamamoto Yasuko, Suzuki Eiji, Tsuda Moe, Kataoka R Tatsuki, Hirata Masahiro, Nishie Mariko, Nojiri Takashi, Kumazoe Motofumi, Saito Kuniaki, Toi Masakazu.
Scientific reports 9 ( 1 ) 2924 - 2924 2019.2
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Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity. International journal
Bae Jaehoon, Kumazoe Motofumi, Fujimura Yoshinori, Tachibana Hirofumi.
The Journal of nutritional biochemistry 64 152 - 161 2019.2
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Saturated fatty acid attenuates anti-obesity effect of green tea. Reviewed
Yamashita Shuya, Hirashima Asami, Lin I-Chian, Bae Jaehoon, Nakahara Kanami, Murata Motoki, Yamada Shuhei , Kumazoe Motofumi, Yoshitomi Ren, Kadomatsu Mai, Sato Yuka, Nezu Ayaka, Hikida Ai, Fujino Konatsu, Murata Kyosuke , Maeda-Yamamoto Mari, Tachibana Hirofumi.
Scientific Reports 8 ( 1 ) 10023 2018.7
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Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells. Reviewed International journal
Bae Jaehoon, Kumazoe Motofumi, Yamashita Shuya, Tachibana Hirofumi.
SCIENTIFIC REPORTS 7 ( 1 ) 6665 - 6665 2017.7
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Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor. Reviewed
Huang Yuhui, Sumida Mami, Kumazoe Motofumi, Sugihara Kaori, Suemasu Yumi, Yamada Shuhei, Yamashita Shuya, Miyakawa Jyunichi, Takahashi Takashi, Tanaka Hiroshi, Fujimura Yoshinori, Tachibana Hirofumi.
CHEMICAL COMMUNICATIONS 53 ( 12 ) 1941 - 1944 2017.2
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Green tea cultivar 'Benifuuki' potentiates split vaccine-induced immunoglobulin A production. Reviewed
Won Yeong-Seon, Kumazoe Motofumi, Takamatsu Kanako, Shinoda Yuki, Sonoda Saki, Okada Kenji, Okamoto Takehisa, Tachibana Hirofumi.
JOURNAL OF NATURAL MEDICINES 71 ( 1 ) 68 - 75 2017.1
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The Synthesis of trans-Flavan-3-ol Gallates by Regioselective Oxidative Etherification and Their Cytotoxicity Mediated by 67LR. Reviewed
Shiraishi Nana, Kumazoe Motofumi, Fuse Shinichiro, Tachibana Hirofumi, Tanaka Hiroshi.
CHEMISTRY-A EUROPEAN JOURNAL 22 ( 37 ) 13050 - 13053 2016.9
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6-Azido-6-deoxy-L-idose as a Hetero-Bifunctional Spacer for the Synthesis of Azido-Containing Chemical Probes. Reviewed
Hamagami Hiroki, Kumazoe Motofumi, Yamaguchi Yoshiki, Fuse Shinichiro, Tachibana Hirofumi, Tanaka Hiroshi.
CHEMISTRY-A EUROPEAN JOURNAL 22 ( 36 ) 12884 - 12890 2016.8
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The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Is Accompanied by Suppression of Cholesterol Synthesis Enzymes. Reviewed
Yamashita Mai, Kumazoe Motofumi, Nakamura Yuki, Won Yeong Seon, Bae Jaehoon, Yamashita Shuya, Tachibana Hirofumi.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 62 ( 4 ) 249 - 256 2016.8
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Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice. Reviewed
Lin I-Chian, Yamashita Shuya, Murata Motoki, Kumazoe Motofumi, Tachibana Hirofumi.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY 32 101 - 106 2016.6
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Green Tea Catechin Metabolites Exert Immunoregulatory Effects on CD4(+) T Cell and Natural Killer Cell Activities. Reviewed
Kim Yoon Hee, Won Yeong-Seon, Yang Xue, Kumazoe Motofumi, Yamashita Shuya, Hara Aya, Takagaki Akiko, Goto Keiichi, Nanjo Fumio, Tachibana Hirofumi.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64 ( 18 ) 3591 - 3597 2016.5
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gamma-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein. Reviewed
Yamashita Shuya, Baba Kiwako, Makio Akiko, Kumazoe Motofumi, Huang Yuhui, Lin I-Chian, Bae Jaehoon, Murata Motoki, Yamada Shuhei, Tachibana Hirofumi.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 473 ( 4 ) 801 - 807 2016.5
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Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells. Reviewed
Yamada Shuhei, Tsukamoto Shuntaro, Huang Yuhui, Makio Akiko, Kumazoe Motofumi, Yamashita Shuya, Tachibana Hirofumi.
SCIENTIFIC REPORTS 6 19225 2016.1
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Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. Reviewed
Tsukamoto Shuntaro, Huang Yuhui, Kumazoe Motofumi, Lesnick Connie, Yamada Shuhei, Ueda Naoki, Suzuki Takashi, Yamashita Shuya, Kim Yoon Hee, Fujimura Yoshinori, Miura Daisuke, Kay E. Neil, Shanafelt D. Tait, Tachibana Hirofumi.
MOLECULAR CANCER THERAPEUTICS 14 ( 10 ) 2303 - 2312 2015.10
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1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Reviewed
26 ( 1 ) 30 - 36 2015.5
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67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance. Reviewed
Tsukamoto Shuntaro, Huang Yuhui, Umeda Daisuke, Yamada Shuhei, Yamashita Shuya, Kumazoe Motofumi, Kim Yoonhee, Murata Motoki, Yamada Koji, Tachibana Hirofumi.
JOURNAL OF BIOLOGICAL CHEMISTRY 289 ( 47 ) 32671 - 32681 2014.11
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IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation. Reviewed
450 ( 1 ) 824 - 830 2014.7
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Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder. Reviewed
Takashi Suzuki, Motofumi Kumazoe, Yoonhee Kim, Shuya Yamashita, Kanami Nakahara, Shuntaro Tsukamoto, Masako Sasaki, Takatoki Hagihara, Yukari Tsurudome, Yuhui Huang, Mari Maeda-Yamamoto, Yuki Shinoda, Wataru Yamaguchi, Koji Yamada, Hirofumi Tachibana.
SCIENTIFIC REPORTS 3 2013.9
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Anti-Cancer Effect of Water Extracts Prepared from Chrysanthemum Flowers and Leaves Shiranui Himekiku Invited Reviewed
Murayama Kanako, Sawa Tomoko, Koga Hiroaki, Yamaguchi Satoshi, Kumazoe Motofumi, Otsuka Takafumi, Miyazaki Yoshiyuki, Tachibana Hirofumi, Koji Yamada.
Nippon Shokuhin Kagaku Kogaku Kaishi 60 ( 2 ) 80 - 86 2013.2
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Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG. Reviewed
Tsukamoto Shuntaro, Yamashita Shuya, Kim Yoon Hee, Kumazoe Motofumi, Huang Yuhui, Yamada Koji, Tachibana Hirofumi.
FEBS LETTERS 586 ( 19 ) 3441 - 3447 2012.9
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Isoflavones suppress the expression of the FcεRI high-affinity immunoglobulin receptor independent of the estrogen receptor. Reviewed
60 ( 34 ) 8379 - 8385 2012.8
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Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells. Reviewed
443 ( 2 ) 525 - 534 2012.4
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Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract. Reviewed
Kim Yoon Hee, Ida Megumi, Yamashita Shuya, Tsukamoto Shuntaro, Kumazoe Motofumi, Sumida Mami, Kawakami Mitsuo, Yamada Koji, Tachibana Hirofumi.
Bioscience of Microbiota, Food and Healt 31 ( 1 ) 1 - 6 2012.1
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Vitamin A Enhances Antitumor Effect of a Green Tea Polyphenol on Melanoma by Upregulating the Polyphenol Sensing Molecule 67-kDa Laminin Receptor. Reviewed
Lee Ju Hye, Kishikawa Mutsumi, Kumazoe Motofumi, Yamada Koji, Tachibana Hirofumi.
PLOS ONE 5 ( 6 ) 2010.6
Books
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緑茶の機能性と薬理 緑茶カテキンセンシングと機能性増強技術
藤村由紀, 熊添基文, 立花宏文（ Role： Joint author）
機能性食品と薬理栄養 2019.8
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茶カテキンの活性発現機序に基づいた新たながん治療戦略
熊添基文, 立花 宏文（ Role： Joint author）
バイオサイエンスとインダストリー 2018.11
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個人に適した効果的な摂取条件等を特定する手法の開発及び摂取条件等を普及するためのモデル体制の構築(茶)第1章 緑茶の機能性感知調節作用の研究開発
立花宏文, 山下修矢, 熊添基文（ Role： Joint author）
農林水産省農林水産技術会議事務局研究成果 (農林水産技術会議事務局研究成果) 2015.2
Presentations
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メチル化EGCGによるスプリット型ワクチンの作用増強
熊添基文，高松香菜子, 藤村由紀, 立花宏文
2021年度西日本・中四国・関西支部 合同大会 2021.9
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Epigallocatechin-3-O-gallate(EGCG)/Phosphodiesterase3阻害剤併用は膵臓がんのがん幹細胞性を阻害する
熊添基文, 高井美佳, 廣井舜, 高松香菜子, 門松舞, 山下麻衣, 藤村由紀, 立花宏文
日本農芸化学会 2020年度大会 2020.3
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cGMP mediates beneficial effect of EGCG. Invited International conference
Kumazoe M, Yoshinori F, Tachibana H.
International Conference on Food Factors 2019.11
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EGCG induces cancer-specific cell death via the sensing receptor-mediated cGMP production. Invited International conference
Kumazoe M, Tachibana H.
Functional and Medical Foods, Bioactive Compounds and Biomarkers 2015.11
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EGCG induces cancer-specific cell death via the sensing receptor-mediated cGMP production. Invited International conference
Kumazoe M, Tachibana H.
International Conference on Tea. 2013.12
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67-kDa laminin receptor and cGMP induced cancer-selective apoptosis. Invited International conference
Kumazoe M, Tachibana H.
The 6th International Meeting on cGMP 2013.6
MISC
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67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG Reviewed
Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana
Current Pharmacology Reports 2020.1
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緑茶カテキンセンシング機構とその応用展開-カテキンパワーの引き出し方. Reviewed
熊添基文, 立花 宏文
化学と生物 2016.3
Industrial property rights
| Patent | Number of applications: 1 | Number of registrations: 0 |
| Utility model | Number of applications: 0 | Number of registrations: 0 |
| Design | Number of applications: 0 | Number of registrations: 0 |
| Trademark | Number of applications: 0 | Number of registrations: 0 |
Professional Memberships
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日本農芸化学会
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日本栄養・食糧学会
Academic Activities
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座長
日本農芸化学会中四国・西日本支部2023年度合同大会 2023.9
Research Projects
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血管内皮細胞を起点とする抗炎症機構の解明
Grant number：20K05960 2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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血管内皮細胞を起点とする抗炎症機構の解明
Grant number：20K05960 2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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cGMPの生体調節作用
2018.4 - 2022.6
Authorship：Principal investigator
cGMPの生体保護作用の解明とその調節法の開発
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ANPの組織繊維化抑制作用の機序解明と肺線維症治療への応用
Grant number：18K06909 2018 - 2020
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
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cGMP の癌幹細胞抑制作用の機構解明
Grant number：18K14442 2018 - 2019
日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Grant type：Scientific research funding
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小児がんに関する研究 (具体的内容は非公開)
2017 - 2019
がんの子供を守る会
Authorship：Principal investigator Grant type：Contract research
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癌幹細胞に対する直ちに臨床応用可能な治療戦略の確立
2017 - 2018
興和生命科学振興財団
Authorship：Principal investigator Grant type：Contract research
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cGMP の抗がん作用機構の解明と臨床応用への基盤確立
2017 - 2018
武田科学振興財団
Authorship：Principal investigator Grant type：Contract research
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天然物の作用機構解明に基づく新規がん細胞致死機構の探索
Grant number：15K18821 2015 - 2017
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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食品因子センシング調節を介した食品間の機能的相互作用の解明
Grant number：15K16231 2015 - 2016
科学研究費助成事業 若手研究(B)
Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid) Grant type：Scientific research funding
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緑茶カテキンＥＧＣＧをリード化合物とするがん幹細胞を殺傷する新規化合物の作製 （日本学術振興会PD）
Grant number：14J30004 2014 - 2016
日本学術振興会 科学研究費助成事業 特別研究員奨励費
Authorship：Principal investigator Grant type：Scientific research funding
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ＥＧＣＧ のプローブ化によるがん医療への応用 (日本学術振興会DC1)
Grant number：11J01339 2011 - 2013
日本学術振興会 科学研究費助成事業 特別研究員奨励費
Authorship：Principal investigator Grant type：Scientific research funding
Class subject
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食糧化学実験
2023.4 - 2023.9 First semester
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微生物学基礎実験
2022.10 - 2023.3 Second semester
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食糧化学実験
2022.4 - 2022.9 First semester
Media Coverage
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柑橘ポリフェノールと緑茶ポリフェノール併用により顕著な抗肥満作用を発揮することをヒト臨床試験により確認した
マイナビnニュース 2021.10
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緑茶とみかんの成分 抗アレルギー 相乗効果 Newspaper, magazine
日本経済新聞 2018.4
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九大、膵臓がん幹細胞の生存・ 転移に重要なしくみを攻撃する化合物を発見 Newspaper, magazine
日本経済新聞 2017.5
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緑茶の作用を強める組み合わせ Newspaper, magazine
朝日新聞 2013.1