Updated on 2024/11/01

Information

 

写真a

 
NAGASAWA TAKAHIRO
 
Organization
Faculty of Agriculture Department of Bioscience and Biotechnology Assistant Professor
School of Agriculture Department of Bioresource and Bioenvironment（Concurrent）
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioscience and Biotechnology（Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Profile
近年、水産養殖の現場においてはワクチン等魚自身の免疫系を利用した病害防除手法が用いられているが、これらの手法は主として哺乳類の知見を基にしたものであり、必ずしも魚類に最適な手法とはいえない。脊椎動物である魚類は基本的には我々哺乳類と同様な免疫系を有しているが、水圏環境に適応するため独自に免疫系の一部を進化させてきた側面をもつ。これまでの研究で、従来哺乳類の血小板に相当するとされていた魚類の栓球が、細菌などの異物を積極的に貪食、殺菌する免疫細胞として機能していることを示してきた。これら魚類独自の免疫システムの全容を解明し、次世代の養殖業における病害防除手法開発への知見とすることを目指す。
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Degree

  • PhD (agriculture)

Research Interests・Research Keywords

  • Research theme：Study of for sexual cycles of Elasmobranchii for their reproduction in aquarium

    Keyword：Elasmobranchii, hormone, shark

    Research period： 2017.2

  • Research theme：Study of an activation of innate immune response by fish B cells

    Keyword：Fish immunology, B cell, innnate immunity

    Research period： 2015.12

  • Research theme：Study of a regulation of inflammatory/anti-inflammatory response by phagocytic fish thrombocytes

    Keyword：Fish immunology, thrombocyte, innnate immunity

    Research period： 2015.12

Awards

  • 第七回ユニーク会最優秀ポスター賞

    2022.9  

  • Best Junior Presentation Award -First Prize

    2012.7   International Society of Developmental and Comparative Immunology  

Papers

  • Characterization of CD83 homologs differently expressed during monocytes differentiation in ginbuna crucian carp, <i>Carassius auratus langsdorfii</i>.

    Tran, TT; Prakash, H; Nagasawa, T; Nakao, M; Somamoto, T

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   159   105212   2024.10   （ ISSN:0145-305X eISSN:1879-0089 ）

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    Language：English   Publisher：Developmental and Comparative Immunology  

    CD83 is a costimulatory molecule of antigen-presenting cells (APCs) that plays an important role in eliciting adaptive responses. It is also a well-known surface protein on mature dendritic cells (DCs). Furthermore, monocytes have been reported to differentiate into macrophages and monocyte-derived dendritic cells, which play an important role in innate immunity. CD83 expression affects the activation and maturation of DCs and stimulates cell-mediated immune responses. This study aims to reveal the CD83 expression during monocyte differentiation in teleosts, and the CD83 homologs evolutionary relationship. This study found two distinct CD83 homologs (GbCD83 and GbCD83-L) in ginbuna crucian carp (Gb) and investigated the evolutionary relationship among GbCD83 homologs and other vertebrates and the gene and protein expression levels of the homologs during 4 days of monocyte culture. The phylogenetic tree showed that the two GbCD83 homologs are classified into two distinct branches. Interestingly, only ostariophysians (Gb, common carp, rohu, fathead minnow and channel catfish), but not neoteleosts, mammals, and others, have two CD83 homologs. Morphological observation and colony-stimulating factor-1 receptor (CSF-1R), CD83, CD80/86, and CCR7 gene expressions illustrated that there is a differentiation of monocytes isolated from peripheral blood leukocytes after 4 days. Specifically, gene expression and immunocytochemistry revealed that GbCD83 is mainly expressed on monocytes at the early stage of cell culture, whereas GbCD83-L is expressed in the latter stage. These findings provided the first evidence of differential expression of CD83 homologs during monocytes differentiation in teleost.

    DOI： 10.1016/j.dci.2024.105212

    Web of Science

    Scopus

    PubMed

  • LIGAND SPECIFICITY AND ACTIVE SIGNALING OF COMMON CARP (<i>CYPRINUS CARPIO</i>) THROMBOCYTES VIA TOLL-LIKE RECEPTOR PATHWAYS

    Ryu, T; Nagasawa, T; Somamoto, T; Nakao, M

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   148   2023.11   （ ISSN:0145-305X eISSN:1879-0089 ）

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  • CHARACTERIZATION OF CD83 ISOTYPES EXPRESSED ON MONOCYTE-MACROPHAGE LINEAGE IN GINBUNA CRUCIAN CARP

    Trang, TT; Nagasawa, T; Nakao, M; Somamoto, T

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   148   2023.11   （ ISSN:0145-305X eISSN:1879-0089 ）

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  • Non-specific cytotoxic cell receptor protein-1 (NCCRP-1) is involved in anti-parasite innate CD8+ T cell-mediated cytotoxicity in ginbuna crucian carp Reviewed International journal

    Masaki Sukeda, Harsha Prakash, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    Fish and Shellfish Immunology   139   108904   2023.8   （ ISSN:1050-4648 eISSN:1095-9947 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.fsi.2023.108904

    Web of Science

    Scopus

    PubMed

  • Non-specific cytotoxic cell receptor protein-1 (NCCRP-1) is involved in anti-parasite innate CD8^+ T cell-mediated cytotoxicity in ginbuna crucian carp

    Sukeda Masaki, Prakash Harsha, Nagasawa Takahiro, Nakao Miki, Somamoto Tomonori

    Fish & Shellfish Immunology   139   108904   2023.8   （ ISSN:10504648 eISSN:10959947 ）

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    Language：English  

    CD8^+ cytotoxic T cells (CTLs) are a main cellular component of adaptive immunity. Our previous research has shown that CD8^+ cells demonstrate spontaneous cytotoxic activity against the parasite Ichthyophthirius multifiliis in ginbuna crucian carp, suggesting that CD8^+ cells play an important role in innate immunity. Herein, we investigated the molecules and cellular signal pathways involved in the cytotoxic response of ginbuna crucian carp. We considered non-specific cytotoxic receptor protein-1 (NCCRP-1) as candidate molecule for parasite recognition. We detected NCCRP-1 protein in CD8^+ cells and the thymus as well as in other cells and tissues. CD8^+ cells expressed mRNA for NCCRP-1, Jak2, and T cell-related molecules. In addition, treatment with a peptide containing the presumed antigen recognition site of ginbuna NCCRP-1 significantly inhibited the cytotoxic activity of CD8^+ cells against the parasites. The cytotoxic activity of CD8^+ cells was significantly inhibited by treatment with the JAK1/2 inhibitor baricitinib. These results suggest that teleost CTLs recognize I. multifiliis through NCCRP-1 and are activated by JAK/STAT signaling.

    CiNii Research

  • Functional Analysis of Two Divergent C4 Isotypes in the Classical and Lectin Pathways of Complement Activation in the Common Carp (<i>Cyprinus carpio</i>)

    Nehlah, R; Yamamoto, A; Nagasawa, T; Somamoto, T; Nakao, M

    JOURNAL OF MARINE SCIENCE AND ENGINEERING   11 ( 4 )   2023.4   （ eISSN:2077-1312 ）

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    Publisher：Journal of Marine Science and Engineering  

    In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide range of vertebrate species including teleost fish, possibly supporting the robust activation mechanism of the complement. To better understand the functional diversity of C4 isotypes in the teleost complement system, two C4 isotypes, C4-1 and C4-2, sharing only 32% amino acid sequence identity, were examined for binding specificities towards model target molecules representing microbe antigens and towards Gram-positive and -negative bacteria. The results suggest that C4-1 and C4-2 behave similarly in binding to the tested targets, despite the predicted difference in binding specificity based on the thioester catalytic site. The participation of C4-1 in the classical and lectin pathways of complement activation was also explored using pathway-specific activating enzyme complexes, C1r/s and MBL-MASP2. As a result, C4-1 can be activated in both the classical and the lectin pathways, at higher efficiency in the classical pathway. Taken together, the present results imply that both C4-1 and C4-2 isotypes are fully functional in the complement activation cascades, probably playing comparable roles in innate immunity.

    DOI： 10.3390/jmse11040707

    Web of Science

    Scopus

  • Development of a filter device for the prevention of aquatic bacterial disease using a single-chain variable fragment (scFv)-conjugated affinity silk Reviewed International journal

    Scientific Reports   2022.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-022-13408-6

  • Development of a filter device for the prevention of aquatic bacterial disease using a single-chain variable fragment (scFv)-conjugated affinity silk Invited Reviewed International journal

    Scientific Reports   2022.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-022-13408-6

  • Local immune responses to two stages of Ichthyophthirius multifiliis in ginbuna crucian carp Fish and Shellfish Immunology Invited Reviewed International journal

    Fish and Shellfish Immunology   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Innate cell-mediated cytotoxicity of CD8(+) T cells against the protozoan parasite Ichthyophthirius multifiliis in the ginbuna crucian carp, Carassius auratus langsdorfii Invited Reviewed International journal

    #Sukeda Masaki, #Shiota Koumei, @Kondo Masakazu, Nagasawa Takahiro, Nakao Miki, Somamoto Tomonori

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   115   2021.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2020.103886

  • Generation of virus-specific CD8 + T cells by vaccination with inactivated virus in the intestine of ginbuna crucian carp Reviewed

    Seisuke Tajimi, Masakazu Kondo, Teruyuki Nakanishi, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    Developmental and Comparative Immunology   93   37 - 44   2019.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2018.12.009

  • Development of Anti-atypical Aeromonas salmonicida Monoclonal Antibodies for Diagnosis of "New Ulcer Disease" in Koi Carp. Reviewed International journal

    Tomonori Somamoto, Shinpei Maruyama, Takahiro Nagasawa, Miki Nakao, Atsushi Sato, Hajime Hatta, Mitsuru Sato, Yukie Murakami-Yamaguchi, Kumiko Kizu-Mori, Yuki Hirakawa, Hiroshi Narita.

    Fish Pathology.   2018.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Evaluation of probiotic Bacillus aerius B81e isolated from healthy hybrid catfish on growth, disease resistance and innate immunity of Pla-mong Pangasius bocourti Reviewed

    Ratchanu Meidong, Kulwadee Khotchanalekha, Sompong Doolgindachbaporn, Takahiro Nagasawa, Miki Nakao, Kenji Sakai, Saowanit Tongpim

    Fish and Shellfish Immunology   73   1 - 10   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.fsi.2017.11.032

  • Development of anti-atypical aeromonas salmonicida monoclonal antibodies for diagnosis of “new ulcer disease⇝ in koi carp Reviewed

    53 ( 1 )   36 - 39   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    To develop an accurate diagnosis of “new ulcer disease” in koi carp, we produced four monoclonal antibodies (mAbs) against a strain of atypical Aeromonas salmonicida isolated from koi carp. These mAbs did not cross-react with an isolate of atypical A. salmonicida from Japanese flounder and other pathogenic bacteria. Re-isolation from artificially infected koi carp was achieved by selecting the blue colonies on agar medium containing Coomassie brilliant blue, and some of the colonies were detected by immunofluorescent staining using the mAbs. These results suggested that the mAbs can distinguish atypical A. salmonicida from koi carp from resident aeromo-nads.

    DOI： 10.3147/jsfp.53.36

  • Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish Implication for the robust innate defense mechanisms of teleosts Reviewed

    Yumie Tokunaga, Masamichi Shirouzu, Ryota Sugahara, Yasutoshi Yoshiura, Ikunari Kiryu, Mitsuru Ototake, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    Scientific Reports   7 ( 1 )   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-08000-2

  • Carp properdin: Structural and functional diversity of two isotypes Invited Reviewed International journal

    IMMUNOBIOLOGY   221 ( 10 )   1210 - 1210   2016.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.imbio.2016.06.188

  • Expression and homeostatic functions of Tecrem, a CD46-like complement regulatory protein, on epithelial cells in bony fish Invited Reviewed International journal

    IMMUNOBIOLOGY   221 ( 10 )   1209 - 1210   2016.10

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.imbio.2016.06.187

  • Recombinant carp IL-4/13B stimulates in vitro proliferation of carp IgM+ B cells Reviewed

    Takuya Yamaguchi, Shunsuke Miyata, Fumihiko Katakura, Takahiro Nagasawa, Yasuhiro Shibasaki, Takeshi Yabu, Uwe Fischer, Chihaya Nakayasu, Teruyuki Nakanishi, Tadaaki Moritomo

    Fish and Shellfish Immunology   49   225 - 229   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.fsi.2015.12.043

  • Carp thrombocyte phagocytosis requires activation factors secreted from other leukocytes Reviewed

    Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    Developmental and Comparative Immunology   52 ( 2 )   107 - 111   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2015.05.002

  • Carp thrombocyte phagocytosis requires activation factors secreted from other leukocytes Invited Reviewed International journal

    Takahiro Nagasawa

    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   52 ( 2 )   107 - 111   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.dci.2015.05.002

  • A CD46-like molecule functional in teleost fish represents an ancestral form of membrane-bound regulators of complement activation Reviewed

    Masakazu Tsujikura, Takahiro Nagasawa, Satoko Ichiki, Ryota Nakamura, Tomonori Somamoto, Miki Nakao

    Journal of Immunology   194 ( 1 )   262 - 272   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.1303179

  • Phagocytosis by thrombocytes is a conserved innate immune mechanism in lower vertebrates Reviewed

    Takahiro Nagasawa, Chihaya Nakayasu, Aja M. Rieger, Daniel R. Barreda, Tomonori Somamoto, Miki Nakao

    Frontiers in Immunology   5 ( SEP )   2014.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2014.00445

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Presentations

  • TLR-MEDIATED TYPE-I INTERFERON PRODUCTION AND THE REGULATORY MECHANISMS IN CARP THROMBOCYTES International conference

    Takahiro Nagasawa, Tomonori Somamoto, and Miki Nakao

    International conference on Fish & Shellfish Immunology 2019  2019.6 

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    Event date： 2019.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Spain  

  • VIRAL LIGANDS RECOGNITION OF CARP THROMBOCYTES AS NATURAL TYPE I INTERFERON PRODUCING CELLS. International conference

    Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    14th congress of International Society of Developmental and Comparative Immunology  2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • PHYLOGENETIC INFERENCE ON FUNCTIONS OF THE CLASSICAL COMPLEMENT PATHWAY IN BONY FISH International conference

    Miki nakao, Sayo Iwanaga, Takahiro Nagasawa, Tomonori Somamoto

    14th congress of International Society of Developmental and Comparative Immunology  2018.6 

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    Event date： 2018.6

    Language：English  

    Country：United States  

  • Ligand recognition specificity of carp thrombocytes as the natural type I IFN producing cells. International conference

    2017.9 

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    Event date： 2017.9

    Language：English  

    Country：Japan  

  • Phagocytosis by carp thrombocyte needs activation factors secreted from other leukocytes population International conference

    13th congress of International Society of Developmental and Comparative Immunology  2015.6 

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    Event date： 2015.6

    Language：English  

    Country：Spain  

  • Phagocytosis and bactericidal abilities of teleost thrombocytes. International conference

    12th congress of International Society of Developmental and Comparative Immunology  2012.6 

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    Event date： 2012.6

    Language：English  

    Country：Japan  

  • ザイモザン刺激による免疫応答はタイリクバラタナゴの婚姻色の発達を抑制する

    #笠元、荻野由紀子、長澤貴宏、杣本智軌、中尾実樹

    第47回日本比較内分泌学会大会  2023.11 

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    Event date： 2024.11

    Language：Japanese  

    Country：Japan  

  • Preventing parasitic infections caused by Ichthyophthirius multifiliis: A novel approach with a single-chain variable fragment (scFv)-conjugated affinity silk filter device

    #Harsha Prakash, @Mitsuru Sato, @Katsura Kojima, @Chisato Sakuma, Akhil Kizhakkumpat, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    2024.3 

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    Event date： 2024.3

    Language：English  

    Country：Japan  

  • 板鰓類血中細菌叢の網羅比較解析

    長澤貴宏、@喜屋武樹、@伊東隆臣、@進藤英朗、@久志本鉄平 近藤圭佑、@鈴木泰也、@中村雅之、@大塚美加、@土田洋之

    板鰓類研究会シンポジウム2023  2023.12 

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    Event date： 2023.12

    Language：Japanese  

    Country：Japan  

  • Expression of CD83 isotypes during the differentiation of monocyte-macrophage linnage in ginbuna crusian carp

    #Tran Thu Trang, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    2023.9 

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    Event date： 2023.9

    Language：English  

    Country：Japan  

  • ギンブナ後腸部に存在する嚢状組織のリンパ組織としての特性

    #浅沼里利香、長澤貴宏、中尾実樹、杣本智軌

    日本比較免疫学会第34回学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese  

    Country：Japan  

  • エドワジエラ症耐性ヒラメの粘膜免疫因子の探索

    #椿野鈴、@吉井啓亮、@岡本裕之、@大野薫、@牧野由美子、長澤貴宏、杣本智軌、中尾実樹

    日本比較免疫学会第34回学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese  

    Country：Japan  

  • コイ栓球はToll様受容体を介して抗原特異的に応答する

    #笠元、長澤貴宏、杣本智軌、中尾実樹

    日本比較免疫学会第34回学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese  

    Country：Japan  

  • Molecular cloning of zymosan-binding lectin in the banded houndshark(Triakis schllium)

    #Jianing Zhu, Chihori Tomoi, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    2023.9 

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    Event date： 2023.9

    Language：English  

    Country：Japan  

  • SCR1,2 domain of a CD46-like regulator of complement activation in teleost is potentially the binding site of Koi Herpesvirus for Koi fin-1 cell infection

    #Nguyen Quang Khai, Harsha Prakash, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    2023.9 

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    Event date： 2023.9

    Language：English  

    Country：Japan  

  • Ligand specificity and active signaling of common carp (Cyprinus carpio) thrombocytes via toll-like receptor pathways International conference

    #Tsukasa Ryu, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    16th Congress of the International Society for Developmental and Comparative Immunology  2023.8 

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    Event date： 2023.8 - 2023.9

    Language：English  

    Country：Japan  

  • Characterization of CD83 isotypes expressed in monocyte-macrophage lineage in ginbuna crucian carp International conference

    #Tran Thu Trang, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    16th Congress of the International Society for Developmental and Comparative Immunology  2023.8 

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    Event date： 2023.8 - 2023.9

    Language：English  

    Country：Japan  

  • Exploration of antigen-trapping sites in ginbuna crucian carp

    2022.1 

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    Event date： 2022.1

    Language：Japanese  

    Country：Japan  

  • 板鰓類⾎中に常在する細菌叢の検出と解析

    長澤貴宏

    板鰓類シンポジウム2021  2021.12 

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    Event date： 2021.12

    Language：Japanese  

    Country：Japan  

  • コイ体表粘液中の補体成分と補体活性化

    吉迫郁子、長澤貴宏、杣本智軌、中尾実樹

    日本補体学会  2021.9 

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    Event date： 2021.9

    Language：Japanese  

    Country：Japan  

  • コイ血清中におけるC3 の二量体形成

    畠山紗矢香、長澤貴宏、杣本智軌、中尾実樹

    日本補体学会  2021.9 

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    Event date： 2021.9

    Language：Japanese  

    Country：Japan  

  • 魚類CD8+ T細胞のMHC非依存的な細胞媒介性細胞傷害における寄生原虫認識受容体の同定

    #助田将樹、長澤貴宏、中尾実樹、杣本智軌

    R3年度日本水産学会春季大会  2021.3 

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    Event date： 2021.3

    Language：Japanese  

    Country：Japan  

  • アユカリクレクチンはオプソニンとして働く

    長澤貴宏、@池尻夏菜、@大野薫、@牧野由美子、#笠元、杣本智軌、中尾実樹

    R3年度日本水産学会春季大会  2021.3 

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    Event date： 2021.3

    Language：Japanese  

    Country：Japan  

  • 軟骨魚類自然抗体の抗原結合能に及ぼす生息地域の影響

    @藤村拓実、@室谷冬香、@野崎玲子、@矢澤良輔、長澤貴宏、杣本智軌、中尾実樹、@廣野育生、@近藤秀裕

    R2年度日本水産学会春季大会  2020.3 

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    Event date： 2020.3

    Language：Japanese  

    Country：Japan  

  • アユのザイモサン結合性レクチンの機能解析

    長澤貴宏、@池尻夏菜、杣本智軌、中尾実樹

    R2年度日本水産学会春季大会  2020.3 

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    Event date： 2020.3

    Language：Japanese  

    Country：Japan  

  • イヌザメ血清レクチンの構造・機能解析

    @鳥居爽花、長澤貴宏、中尾実樹

    R2年度日本水産学会春季大会  2020.3 

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    Event date： 2020.3

    Language：Japanese  

    Country：Japan  

  • ギンブナの細胞外寄生原虫に対する細胞傷害機構におけるシグナル伝達経路の探索

    #助田将樹、長澤貴宏、#塩田昂明、中尾実樹、杣本智軌

    R2年度日本水産学会春季大会  2020.3 

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    Event date： 2020.3

    Language：Japanese  

    Country：Japan  

  • 魚類免疫学の近年の概況～粘膜免疫と寄生虫対策～ Invited

    長澤貴宏

    第35回九州沖縄ブロック動物園水族館獣医師臨床研究会  2020.2 

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    Event date： 2020.2

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Country：Japan  

  • 飼育下シロワニの飼育環境変化と繁殖周期

    @鈴木泰也、@牧貴海、@中村雅之、長澤貴宏、@シロワニ繁殖協議会

    第64回水族館技術者研究会  2020.1 

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    Event date： 2020.1

    Language：Japanese  

    Country：Japan  

  • Functional analysis of two complement C4 isotypes of carp using recombinant proteins International conference

    Nehlal Rosli, Takahiro Nagasawa, Tomonri Somamoto, Miki Nakao

    The 1st Congress of Asian Society of Developmental and Comparative Immunology  2019.12 

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    Event date： 2019.12

    Language：English  

    Country：Japan  

  • 魚類免疫学の近年の概況～粘膜免疫と寄生虫対策～

    令和元年度日本水産学会九州支部会  2019.12 

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    Event date： 2019.12

    Language：English  

    Country：Japan  

  • アフィニティーシルクを用いた魚病細菌除去フィルターの開発

    Harsha Prakash、#丸山真平、@佐藤充、@小島桂、@佐藤巧視、長澤貴宏、中尾実樹、杣本智軌

    令和元年度日本魚病学会秋季大会  2019.9 

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    Event date： 2019.9

    Language：English  

    Country：Japan  

  • 魚類炎症反応におけるC5aの役割解明のための組換えゼブラフィッシュ C5aの作製

    #齋藤武尊、長澤貴宏、杣本智軌、中尾実樹

    R元年度日本水産学会秋季大会  2019.9 

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    Event date： 2019.9

    Language：Japanese  

    Country：Japan  

  • ドチザメ血清中のザイモサン結合タンパク質の同定

    #友井千帆里、長澤貴宏、@濵虹花、杣本智軌、中尾実樹

    日本比較免疫学会第31回学術集会  2019.9 

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    Event date： 2019.9

    Language：Japanese  

    Country：Japan  

  • Direct cytotoxic activity of CD8+ T cells against Ichthyophthirius multifiliis in ginbuna crucian carp, Carassius auratus langsdorfii International conference

    Masaki Sukeda, Koumei Shiota, Takahiro Nagasawa, Miki Nakao, Tomonori Somamoto

    International conference on Fish & Shellfish Immunology 2019  2019.6 

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    Event date： 2019.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Spain  

  • 魚類炎症反応におけるC5aの役割解明のための抗ゼブラフィッシュC5a抗体の作成

    斎藤武尊, 長澤 貴宏, 杣本智軌, 中尾実樹

    H31年度日本水産学会春季大会  2019.3 

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    Event date： 2019.3

    Language：Japanese  

    Country：Japan  

  • 特異抗体を利用したコイ補体成分C5の迅速精製

    中尾実樹, 木村美智代, 長澤貴宏, 杣本智軌

    H31年度日本水産学会春季大会  2019.3 

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    Event date： 2019.3

    Language：Japanese  

    Country：Japan  

  • 繊毛虫Ichtyophthiriusmultifiliisの成長段階の違いによるギンブナの免疫応答の比較

    塩田昂明, 助田将樹, 中西照幸, 長澤貴宏, 中尾実樹, 杣本智軌

    H31年度日本水産学会春季大会  2019.3 

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    Event date： 2019.3

    Language：Japanese  

    Country：Japan  

  • シロワニ繁殖協議会の活動について

    中村雅之・⻑澤貴宏・シロワニ繁殖協議会

    板鰓類シンポジウム2018 in長崎  2018.12 

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    Event date： 2018.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Nagasaki, Japan   Country：Japan  

  • Activity of Reproductive Management Committee for Sand Tiger Sharks International conference

    Masayuki Nakamura, Keisuke Kondo,Takahiro Nagasawa and Reproductive Management Committee for Sand Tiger Sharks

    10th Intenational Aquarium Congress 2018 Fukushima Japan  2018.11 

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    Event date： 2018.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Activity of Reproductive Management Committee for Sand Tiger Sharks International conference

    Masayuki Nakamura, Keisuke Kondo,Takahiro Nagasawa and Reproductive Management Committee for Sand Tiger Sharks

    International workshop of Sand Tiger Sharks  2018.9 

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    Event date： 2018.9

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • ギンブナCD8+Tリンパ球の寄生原虫に対する細胞遊走活性

    助田将樹, 塩田昴明, 長澤貴宏, 中尾実樹, 杣本智軌

    H30年度日本水産学会秋季大会  2018.9 

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    Event date： 2018.9

    Language：Japanese  

    Country：Japan  

  • Functional analysis of the classical activation pathway in teleost fish complement system: an evolutionary implication. International conference

    Miki Nakao, Sayo Iwanaga, Takahiro Nagasawa, Tomonori Somamoto

    Asian invertebrate immunity symposium 2018  2018.9 

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    Event date： 2018.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Type I IFN production by carp thrombocytes as professional antiviral leukocytes, like mammalian plasmacytoid dendritic cells, via IRF7 signaling pathway. International conference

    Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    Asian invertebrate immunity symposium 2018  2018.9 

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    Event date： 2018.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 硬骨魚類における古典経路の機能解析から系統発生学的考察

    中尾実樹, 岩永彩代, 長澤貴宏, 杣本智軌

    第55回日本補体学会学術集会  2018.8 

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    Event date： 2018.8 - 2018.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • コイ体表粘液中に存在する補体成分の検出

    吉迫郁子, 黒木将武, 長澤貴宏, 杣本智軌, 中尾実樹

    第30回日本比較免疫学会学術集会  2018.8 

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    Event date： 2018.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Homeostatic functional analysis of Tecrem, a CD46-like complement regulatory protein, on epithelial cells in carp fish

    Harsha Prakash, Shiori Motobe, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    2018.3 

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    Event date： 2018.3

    Language：Japanese  

    Country：Japan  

  • シロワニ未受精卵排出と性ステロイドホルモン濃度変化

    中村雅之,長澤貴宏,シロワニ繁殖協議会

    H29年度水族館技術者研究会  2017.10 

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    Event date： 2017.10

    Language：Japanese  

    Country：Japan  

  • Functional analysis of tecrem, a CD46-like complement regulatory protein, on epithelial cells in the common carp International conference

    Harsha Prakash, Shiori Motobe, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao

    2017.9 

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    Event date： 2017.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • アフィニティーシルクの魚病細菌感染症診断への応用

    丸山真平、佐藤充、小島桂、長澤貴宏、中尾実樹、杣本智軌

    平成29年日本魚病学会秋季大会  2017.9 

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    Event date： 2017.9

    Language：Japanese  

    Country：Japan  

  • 繊毛虫Ichthyophthirius multifiliis に対する魚類CD8+T細胞の傷害機構

    #助田将樹、長澤貴宏、中尾実樹、杣本智軌

    平成29年日本魚病学会秋季大会  2017.9 

    　More details

    Event date： 2017.9

    Language：Japanese  

    Country：Japan  

  • コイ栓球によるI型インターフェロン産生機構

    長澤貴宏、杣本智軌、中尾実樹

    平成29年日本魚病学会秋季大会  2017.9 

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    Event date： 2017.9

    Language：Japanese  

    Country：Japan  

  • コイ補体成分B/C2-Bの組換え体作製と機能解析

    赤司小百合、長澤貴宏、杣本智軌、中尾実樹

    平成29年度日本比較免疫学会学術集会  2017.8 

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    Event date： 2017.8

    Language：Japanese  

    Country：Japan  

  • コイ栓球のI型インターフェロン産生能

    長澤貴宏、杣本智軌、中尾実樹

    平成29年度日本比較免疫学会学術集会  2017.8 

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    Event date： 2017.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 魚類好中球の異物取り込み・付着を判別する新手法

    長澤 貴宏, 杣本智軌, 中尾 実樹

    日本比較免疫学会  2016.8 

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    Event date： 2016.8

    Language：Japanese  

    Country：Japan  

  • 大豆タンパク質含有飼料が魚類の抗体産生応答に与える影響

    長澤 貴宏, 岡田幸浩, 畑中晃昌, 青木直人, 平澤徳高, 梅田奈央子, 杣本智軌, 中尾 実樹

    2016.3 

    　More details

    Event date： 2016.3

    Language：Japanese  

    Country：Japan  

  • Phagocytic activities of carp (Cyprinus carpio ) thrombocytes International conference

    Comparative Immunology and Pathology Workshop  2011.5 

    　More details

    Event date： 2011.5

    Language：English  

    Country：Canada  

▼display all

Professional Memberships

  • 日本比較免疫学会

  • 国際比較免疫学会

  • 日本水産学会

  • Japanese society for elasmobranch studies

Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2019

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2018

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • 座長（Chairmanship）

    H29年度日本水産学会春季大会  2017.3

    　More details

    Type：Competition, symposium, etc. 

  • 座長（Chairmanship）

    H28年度日本比較免疫学会  2016.8

    　More details

    Type：Competition, symposium, etc. 

Research Projects

  • 軟骨魚類を通じて免疫系の源流に迫る -血中細菌との奇妙な関係性-

    Grant number：24K09073  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    長澤 貴宏

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    軟骨魚類血中に常在する細菌群「血中細菌叢」の存在を証明し、それらが宿主に対して果たす役割を解明するとともに、それら血中細菌との共存/共生を可能とする、軟骨魚類免疫系の病原体パターン認識機構とそれによる免疫調節機構を解明する。脊椎動物免疫系のプロトタイプともいえる軟骨魚類の免疫系が血中の微生物を選択的に排除／許容し、不要な反応を起こさないメカニズムを解明することで、我々が抱える自己免疫疾患やアレルギーの原因、解決の糸口が掴めるかもしれない。

    CiNii Research

  • 研究助成金

    2022

    　 More details

    Grant type：Donation

  • 魚類体表粘膜創傷時における修復機構の解明

    Grant number：21K14917  2021 - 2024

    日本学術振興会  科学研究費助成事業  若手研究

    長澤 貴宏

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    魚の体表は粘液に覆われた粘膜組織であり、それらは水中の病原体に常に晒されているが、実際にはそれらの病原体は体表の傷から侵入しているのではないかと考えた。即ちそうした創傷箇所をいかに早く治癒力こそが実際の耐病性の鍵となっていると考え、それら治癒力を評価するための候補因子を探すことを本研究の目的とした。健常な魚と創傷時の魚で粘液のタンパク成分を網羅的に解析、比較し創傷治癒に重要なタンパクを特定する。

    CiNii Research

  • メタン発酵消化液を液肥利用した場合のジャンボタニシへの影響

    2020

    糸島市協定大学等課題解決型研究事業

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    Authorship：Principal investigator  Grant type：Contract research

  • 研究助成金

    2019

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    Grant type：Donation

  • 研究助成金

    2019

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    Grant type：Donation

  • 研究助成金

    2018

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    Grant type：Donation

  • 低魚粉飼料給餌による魚類体表粘膜修復力低下の原因と作用機構の解明

    2018

    農学研究院若手教員支援事業(チャレンジ研究支援(Ⅰ型))

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 補体活性を抑制した急性ショック・炎症フリー魚の作出

    Grant number：17K15323  2017 - 2019

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 粘膜バリアの評価系作出を目指した魚類体表粘液のプロテオーム解析

    2017

    農学研究院若手教員支援事業(チャレンジ研究支援(Ⅰ型))

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 補体のホメオスタシス機能を活用した魚類粘膜の自然免疫バリアの強化

    Grant number：16H04982  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

▼display all

Class subject

  • 比較免疫学特論

    2024.12 - 2025.2   Winter quarter

  • 水族生化学実験

    2024.6 - 2024.8   Summer quarter

  • 生物機能分子化学プロジェクト演習

    2024.4 - 2025.3   Full year

  • 生物機能分子化学特論2

    2024.4 - 2024.9   First semester

  • 水産科学のフロンティア

    2024.4 - 2024.6   Spring quarter

  • 比較免疫学特論

    2023.12 - 2024.2   Winter quarter

  • 水族生化学実験

    2023.6 - 2023.8   Summer quarter

  • 生物機能分子化学プロジェクト演習

    2023.4 - 2024.3   Full year

  • 生物機能分子化学特論2

    2023.4 - 2023.9   First semester

  • Utilization of Animal and Marine Bioresources

    2023.4 - 2023.9   First semester

  • 水産科学のフロンティア

    2023.4 - 2023.6   Spring quarter

  • 専門英語

    2022.10 - 2023.3   Second semester

  • Core Seminar

    2022.10 - 2022.12   Fall quarter

  • 水族生化学実験

    2022.6 - 2022.8   Summer quarter

  • 生物機能分子化学プロジェクト演習

    2022.4 - 2023.3   Full year

  • Utilization of Animal and Marine Bioresources

    2022.4 - 2022.9   First semester

  • 生物機能分子化学特論2

    2022.4 - 2022.9   First semester

  • 水産科学のフロンティア

    2022.4 - 2022.6   Spring quarter

  • 自然科学総合実験（発展）

    2021.12 - 2022.2   Winter quarter

  • 水産化学実験

    2021.10 - 2022.3   Second semester

  • 比較免疫学特論

    2021.10 - 2022.3   Second semester

  • 専門英語

    2021.10 - 2022.3   Second semester

  • Core Seminar

    2021.10 - 2021.12   Fall quarter

  • 生物機能分子化学プロジェクト演習

    2021.4 - 2022.3   Full year

  • 生物機能分子化学特論1E

    2021.4 - 2021.9   First semester

  • Utilization of Animal and Marine Bioresources

    2021.4 - 2021.9   First semester

  • 自然科学総合実験（発展）

    2020.12 - 2021.2   Winter quarter

  • 比較免疫学特論

    2020.10 - 2021.3   Second semester

  • 学術英語３

    2020.10 - 2021.3   Second semester

  • 水産化学実験

    2020.10 - 2021.3   Second semester

  • 生物機能分子化学プロジェクト演習

    2020.4 - 2021.3   Full year

  • 生物機能分子化学特論2

    2020.4 - 2020.9   First semester

  • Utilization of Animal and Marine Bioresources

    2020.4 - 2020.9   First semester

  • 自然科学総合実験（発展）

    2019.12 - 2020.2   Winter quarter

  • 水産化学実験

    2019.10 - 2020.3   Second semester

  • 学術英語３

    2019.10 - 2020.3   Second semester

  • 比較免疫学特論

    2019.10 - 2020.3   Second semester

  • 生物機能分子化学プロジェクト演習

    2019.4 - 2020.3   Full year

  • Utilization of Animal and Marine Bioresources

    2019.4 - 2019.9   First semester

  • 生物機能分子化学特論1

    2019.4 - 2019.9   First semester

  • 比較免疫学特論

    2018.10 - 2019.3   Second semester

  • 学術英語３

    2018.10 - 2019.3   Second semester

  • 水産化学実験

    2018.10 - 2019.3   Second semester

  • 生物機能分子化学プロジェクト演習

    2018.4 - 2019.3   Full year

  • 生物機能分子化学特論２

    2018.4 - 2018.9   First semester

  • 自然科学総合実験（発展）

    2017.12 - 2018.2   Winter quarter

  • 水産化学実験

    2017.10 - 2018.3   Second semester

  • 生物機能分子化学プロジェクト演習

    2017.4 - 2018.3   Full year

  • 水産化学実験

    2016.10 - 2017.3   Second semester

  • 自然科学総合実験

    2016.10 - 2017.3   Second semester

  • 生物機能分子化学プロジェクト演習

    2016.4 - 2017.3   Full year

▼display all

Other educational activity and Special note

  • 2017  Special Affairs 

Activities contributing to policy formation, academic promotion, etc.

  • 2018.4 - 2020.3   国立研究開発法人科学技術振興機構、九州大学

    国立研究開発法人科学技術振興機構　グローバルサイエンスキャンパス委託事業「九州大学未来創成科学者育成プロジェクト（QFC-SP）」　指導教員として参加

Travel Abroad

  • 2019.6

    Staying countory name 1：Spain   Staying institution name 1：Universidad de Las Palmas de Gran Canaria

  • 2017.2

    Staying countory name 1：United States   Staying institution name 1：University of California, Davis

  • 2016.3

    Staying countory name 1：Australia   Staying institution name 1：James Cook University

  • 2012.2

    Staying countory name 1：United States   Staying institution name 1：The University of Pennsylvania

  • 2012.1 - 2012.2

    Staying countory name 1：Canada   Staying institution name 1：University of Alberta