Updated on 2024/09/30

Information

 

写真a

 
OGINO YUKIKO
 
Organization
Faculty of Agriculture Attached Promotive Center for International Education and Research of Agriculture Associate Professor
Faculty of Agriculture Attached Promotive Center for International Education and Research of Agriculture（Joint Appointment）
School of Agriculture Department of Bioresource and Bioenvironment（Joint Appointment）
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioresource Sciences（Joint Appointment）
Title
Associate Professor
Contact information
メールアドレス
Tel
0928024766
Profile
Education: I am in charge of the classes regarding Ecology and Evolutionary Biology in IUPE general education courses. Research: My research is focused on the molecular basis of androgen-dependent sex characteristics development and evolution, which brings the morphological specification of male-type sex attractive and reproductive organs, and the wide variety of reproductive strategies in vertebrates.
Homepage
External link

Degree

  • Ph.D

Research History

  • Kyushu University Faculty of Agriculture Attached Promotive Center for International Education and Research of Agriculture  Associate Professor

    2016.4 - Present

  • 大学共同利用機関法人　自然科学研究機構　基礎生物学研究所/総合研究大学院大学（２０１０年９月から２０１６年３月、助教） 熊本大学　生命資源研究・支援センター、発生医学研究所　非常勤研究員（１９９９年４月から２０１０年８月）

Research Interests・Research Keywords

  • Research theme：Genetic Basis for Species Differences in Sexual Characteristics, Comparative analysis between Japanese medaka and Indonesian medaka

    Keyword：androgen, sexual character, species differences

    Research period： 2024.4 - 2026.3

  • Research theme：Elucidation of the transcriptional regulatory mechanism that enables the expression of diverse secondary sex characteristics

    Keyword：androgen receptor, transcriptional regulation

    Research period： 2024.3 - 2026.9

  • Research theme：Sex spectrum of the secondary sex characteristics　:　Regulation of size and tissue specificity of sex characteristics by androgen

    Keyword：tissue specificity, sex characteristics, chromatin, androgen effector gene

    Research period： 2020.4 - 2023.3

  • Research theme：Mechanisms of diversification of sex characteristics: a new insight from the functional analysis of androgen receptor genes

    Keyword：sex characteristics, genome duplication

    Research period： 2019.4 - 2023.3

  • Research theme：Analysis of chromatin dynamics during the sex characteristics development

    Keyword：androgen receptor

    Research period： 2018.11 - 2019.10

  • Research theme：Analysis of the relation between sex characteristics development and the individual recognition, the emotional control system using fish as model animal

    Keyword：environment, endocrine system, stress

    Research period： 2018.1 - 2024.8

  • Research theme：Molecular basis of androgen-dependent sex characteristics development and evolution Generation of bio-monitoring medaka

    Keyword：androgen, sex characteristics, morphological diversification, genome duplication, endocrine disruptors

    Research period： 2016.4 - 2023.3

Papers

  • Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish Reviewed International journal

    Yukiko Ogino1,2*, Satoshi Ansai3,4, Eiji Watanabe5,6, Masaki Yasugi7,8, Yukitoshi Katayama9, Hirotaka Sakamoto9, Keigo Okamoto1, Kataaki Okubo10, Yasuhiro Yamamoto11, Ikuyo Hara12,13, Touko Yamazaki12, Ai Kato13, Yasuhiro Kamei6,14, Kiyoshi Naruse6,12,13, Kohei Ohta15, Hajime Ogino16, Tatsuya Sakamoto9, Shinichi Miyagawa17, Tomomi Sato18, Gen Yamada19, Michael E. Baker20, Taisen Iguchi18

    Nat Commun   14 ( 1 )   article NO.1428   2023.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41467-023-37026-6

  • Neofunctionalization of androgen receptor by gain-of-function mutations in teleost fish lineage Reviewed International journal

    Yukiko Ogino, Shigehiro Kuraku, Hiroshi Ishibashi, Hitoshi Miyakawa, Eri Sumiya, Shinichi Miyagawa, Hajime Matsubara, Gen yamada, Michael E. Baker, Taisen Iguchi

    Molecular Biology and Evolution   33   228 - 244   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Bmp7 and Lef1 are the down stream effectors of androgen signaling in androgen-induced sex characteristics development in medaka Reviewed International journal

    Yukiko Ogino, Ikumi Hirakawa, Keiji Inohaya, Eri Sumiya, Shinichi Miyagawa, Nancy Denslow, Gen Yamada, Norihisa Tatarazako, Taisen Iguchi

    Endocrinology   155   449 - 462   2014.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Essential functions of androgen signaling emerged through the developmental analysis of vertebrate sex characteristics Reviewed International journal

    Yukiko Ogino, Shinichi Miyagawa, Hironori Katoh, Gail S. Prins, Taisen Iguchi, Gen Yamada

    Evolution and Development   13   315 - 325   2011.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Evolutionary history and functional characterization of androgen receptor genes in jawed vertebrates Reviewed International journal

    Yukiko Ogino, Hironori Katoh, Shigehiro Kuraku, Gen Yamada

    Endocrinology   150   5415 - 5427   2009.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Fgf8 contributes to the pathogenesis of Nager syndrome.

    Ulhaq ZS, You MS, Yabe T, Takada S, Chen JK, Ogino Y, Jiang YJ, Tse WKF

    International journal of biological macromolecules   135692   2024.9   （ ISSN:0141-8130 ）

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    Language：English  

    DOI： 10.1016/j.ijbiomac.2024.135692

    PubMed

  • Insights into epigenetic regulation of <i>cyp19a</i> via comparative analysis using the scombrid chub mackerel as model

    Galotta, M; Dam, AT; Eto, Y; Toyoda, A; Itoh, T; Mohapatra, S; Ogino, Y; Saitou, M; Matsuyama, M; Chakraborty, T; Ohta, K

    FRONTIERS IN MARINE SCIENCE   11   2024.6   （ eISSN:2296-7745 ）

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    Publisher：Frontiers in Marine Science  

    Sexual development and reproduction are largely linked to epigenetic changes in many fish species. However, understanding of epigenetic regulation in scombrid species, such as tunas and mackerels, is limited. This study investigates DNA methylation’s impact on cyp19a expression, crucial for estrogen synthesis, focusing on chub mackerel. Given the commercial significance of scombrids and susceptibility of marine fish to environmental changes, elucidating epigenetic mechanisms, particularly in the context of global warming, becomes imperative. We aimed to generalize observations from chub mackerel to other scombrids. Additionally, we studied DNA methylation patterns across fish with different sexual systems to understand aromatase regulation’s phenotypic plasticity. Our in silico analysis revealed highly conserved promoter sequences within scombrids, sharing TFBS like Foxl2, FOS::JUN, ESRR, and Sox3, while CpG content varies. This indicates a conserved regulatory network controlling gene expression. We found sexual dimorphism in DNA methylation, with males hypermethylated and aromatase expression downregulated. Despite similar dnmt1 expression, tet1, tet2, and tet3 were higher expressed in females, suggesting that the observed DNA methylation patterns are maintained through active demethylation rather than differential methylation. Gonochoristic Japanese anchovy and protogynous bamboo leaf wrasse displayed similar trends, but species-specific methylation patterns highlight DNA methylation’s complex role in gonadal changes. In vitro assays confirmed methylation’s regulatory role and identified an SF-1 binding site relevant for promoter activation in chub mackerel. Another studied SF-1 site, present in both chub mackerel and bamboo leaf wrasse, showed regulatory effects, indicating potential similar regulatory mechanisms for cyp19a expression. Overall, our findings suggest that while global methylation affects cyp19a transcription, the variation in CpG density and location could be introducing nuances in its epigenetic regulation. This study contributes to our understanding of the cyp19a regulation in fish gonad maturation.

    DOI： 10.3389/fmars.2024.1408561

    Web of Science

    Scopus

  • Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation

    Ulhaq, ZS; Bittencourt, GB; Soraya, GV; Istifiani, LA; Pamungkas, SA; Ogino, Y; Nurputra, DK; Tse, WKF

    MOLECULAR ASPECTS OF MEDICINE   96   101238   2024.4   （ ISSN:0098-2997 eISSN:1872-9452 ）

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    Language：English   Publisher：Molecular Aspects of Medicine  

    Glaucoma is one of the leading causes of visual impairment and blindness worldwide, and is characterized by the progressive damage of retinal ganglion cells (RGCs) and the atrophy of the optic nerve head (ONH). The exact cause of RGC loss and optic nerve damage in glaucoma is not fully understood. The high energy demands of these cells imply a higher sensitivity to mitochondrial defects. Moreover, it has been postulated that the optic nerve is vulnerable towards damage from oxidative stress and mitochondrial dysfunction. To investigate this further, we conducted a pooled analysis of mitochondrial variants related to energy production, specifically focusing on oxidative phosphorylation (OXPHOS) and fatty acid β-oxidation (FAO). Our findings revealed that patients carrying non-synonymous (NS) mitochondrial DNA (mtDNA) variants within the OXPHOS complexes had an almost two-fold increased risk of developing glaucoma. Regarding FAO, our results demonstrated that longer-chain acylcarnitines (AC) tended to decrease, while shorter-chain AC tended to increase in patients with glaucoma. Furthermore, we observed that the knocking down cpt1a (a key rate-limiting enzyme involved in FAO) in zebrafish induced a degenerative process in the optic nerve and RGC, which resembled the characteristics observed in glaucoma. In conclusion, our study provides evidence that genes encoding mitochondrial proteins involved in energy metabolisms, such as OXPHOS and FAO, are associated with glaucoma. These findings contribute to a better understanding of the molecular mechanisms underlying glaucoma pathogenesis and may offer potential targets for therapeutic interventions in the future.

    DOI： 10.1016/j.mam.2023.101238

    Web of Science

    Scopus

    PubMed

  • Transcriptome alterations in <i>sf3b4</i>-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model

    Ulhaq, ZS; Ogino, Y; Tse, WKF

    EXPERIMENTAL EYE RESEARCH   240   109819   2024.3   （ ISSN:0014-4835 eISSN:1096-0007 ）

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    Language：English   Publisher：Experimental Eye Research  

    Posterior subcapsular cataract (PSC) frequently develops as a complication in patients with retinitis pigmentosa (RP). Despite numerous scientific investigations, the intricate pathomechanisms underlying cataract formation in individuals affected by RP remain elusive. Therefore, our study aims to elucidate the potential pathogenesis of cataracts in an RP model using splicing factor subunit 3b (sf3b4) mutant zebrafish. By analyzing our previously published transcriptome dataset, we identified that, in addition to RP, cataract was listed as the second condition in our transcriptomic analysis. Furthermore, we confirmed the presence of nucleus retention in the lens fiber cells, along with abnormal cytoskeleton expression in both the lens fiber cells and lens epithelial cells in sf3b4-depleted fish. Upon closer examination, we identified 20 differentially expressed genes (DEGs) that played a role in cataract formation, with 95 % of them related to the downregulation of structural lens proteins. Additionally, we also identified that among all the DEGs, 13 % were associated with fibrotic processes. It seems that the significant upregulation of inflammatory mediators, in conjunction with TGF-β signaling, plays a central role in the cellular biology of PSC and posterior capsular opacification (PCO) in sf3b4 mutant fish. In summary, our study provides valuable insights into cataract formation in the RP model of sf3b4 mutants, highlighting its complexity driven by changes in structural lens proteins and increased cytokines/growth factors.

    DOI： 10.1016/j.exer.2024.109819

    Web of Science

    Scopus

    PubMed

  • Dysregulation of Spliceosomes Complex Induces Retinitis Pigmentosa-Like Characteristics in sf3b4-Depleted Zebrafish

    Jlhaq, ZS; Okamoto, K; Ogino, Y; Tse, WKF

    AMERICAN JOURNAL OF PATHOLOGY   193 ( 9 )   1223 - 1233   2023.9   （ ISSN:0002-9440 eISSN:1525-2191 ）

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    Language：English   Publisher：American Journal of Pathology  

    The SF3B4 gene encodes a highly conserved protein that plays a critical role in mRNA splicing. Mutations in this gene are known to cause Nager syndrome, a rare craniofacial disorder. Although SF3B4 expression is detected in the optic vesicle before it is detected in the limb and somite, the role of SF3B4 in the eye is not well understood. This study investigated the function of sf3b4 in the retina by performing transcriptome profiles, immunostaining, and behavioral analysis of sf3b4−/− mutant zebrafish. Results from this study suggest that dysregulation of the spliceosome complex affects not only craniofacial development but also retinogenesis. Zebrafish lacking functional sf3b4 displayed characteristics similar to retinitis pigmentosa (RP), marked by severe retinal pigment epithelium defects and rod degeneration. Pathway analysis revealed altered retinol metabolism and retinoic acid signaling in the sf3b4−/− mutants. Supplementation of retinoic acid rescued key cellular phenotypes observed in the sf3b4−/− mutants, offering potential therapeutic strategies for RP in the future. In conclusion, this study sheds light on the previously unknown role of SF3B4 in retinogenesis and provides insights into the underlying mechanisms of RP.

    DOI： 10.1016/j.ajpath.2023.05.008

    Web of Science

    Scopus

    PubMed

  • Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Invited Reviewed International journal

    Ulhaq ZS, Ogino Y, Tse WKF

    Biochem Biophys Res Commun   26 ( 664 )   100 - 107   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18 Reviewed International journal

    2. Ulhaq ZS, Ogino Y, Tse WKF

    Biochem Biophys Res Commun   １６ ( 652 )   76 - 83   2023.4

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  • Characterization of G protein-coupled estrogen receptors in Japanese medaka, Oryzias latipes. Reviewed International journal

    Miyaoku K, Ogino Y, Lange A, Ono A, Kobayashi T, Ihara M, Tanaka H, Toyota K, Akashi H, Yamagishi G, Sato T, Tyler CR, Iguchi T, Miyagawa S.

    J Appl Toxicol   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jat.4130.

  • Juvenile hormone-independent function of Krüppel homolog 1 in early development of water flea Daphnia pulex Reviewed

    93   12 - 18   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ibmb.2017.12.007

  • Establishment of estrogen receptor 1 (ESR1)-knockout medaka ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes Reviewed

    Saki Tohyama, Yukiko Ogino, Anke Lange, Taijun Myosho, Tohru Kobayashi, Yu Hirano, Gen Yamada, Tomomi Sato, Norihisa Tatarazako, Charles R. Tyler, Taisen Iguchi, Shinichi Miyagawa

    Development Growth and Differentiation   59 ( 6 )   552 - 561   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/dgd.12386

  • Characterization of evolutionary trend in squamate estrogen receptor sensitivity. Reviewed International journal

    Ryohei Yatsu, Yoshinao Katsu, Satomi Kohno, Takeshi Mizutani, Yukiko Ogino, Yasuhiko Ohta, Jan Myburgh, Johannes H. van Wyk, Louis J. Guillette Jt., Shinich Miyagawa, Taisen Iguchi

    General and Comparative Endocrinology   238   88 - 95   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi: 10.1016/j.ygcen.2016.04.005.

  • Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish Reviewed

    Tatsuya Sakamoto, Madoka Yoshiki, Hideya Takahashi, Masayuki Yoshida, Yukiko Ogino, Toshitaka Ikeuchi, Tomoya Nakamachi, Norifumi Konno, Kouhei Matsuda, Hirotaka Sakamoto

    Scientific Reports   6   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep37991

  • Evolution of estrogen receptors in ray-finned fish and their comparative responses to estrogenic substances Reviewed

    Saki Tohyama, Shinichi Miyagawa, Anke Lange, Yukiko Ogino, Takeshi Mizutani, Masaru Ihara, Hiroaki Tanaka, Norihisa Tatarazako, Tohru Kobayashi, Charles R. Tyler, Taisen Iguchi

    Journal of Steroid Biochemistry and Molecular Biology   158   189 - 197   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jsbmb.2015.12.009

  • Neverland regulates embryonic moltings through the regulation of ecdysteroid synthesis in the water flea Daphnia magna, and may thus act as a target for chemical disruption of molting. Reviewed International journal

    Eri Sumiya, Yukiko Ogino, Kenji Toyota, Hitoshi Miyakawa, Shinich Miyagawa, Taisen Iguchi

    Journal of Applied Toxicology   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jat.3306.

  • Comparative developmental staging of female and male water fleas daphnia pulex and daphnia magna during embryogenesis Reviewed

    Kenji Toyota, Chizue Hiruta, Yukiko Ogino, Shinichi Miyagawa, Tetsuro Okamura, Yuta Onishi, Norihisa Tatarazako, Taisen Iguchi

    Zoological Science   33 ( 1 )   31 - 37   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2108/zs150116

  • RNA-seq analysis of the gonadal transcriptome during Alligator mississippiensis temperature-dependent sex determination and differentiation. Reviewed International journal

    Ryohei Yatsu, Shinichi Miyagawa, Satomi Kohno, Benjamin B. Parrott, Katsushi Yamaguchi, Yukiko Ogino, Hitoshi Miyakawa, Russell H. Lowers, Shuji Shigenobu, Louis J. GuilletteJr., Taisen Iguchi

    BMC Genomics   17   77   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi: 10.1186/s12864-016-2396-9.

  • TRPV4 associates environmental temperature and sex determination in the American alligator Reviewed International journal

    Ryohei Yatsu, Shinichi Miyagawa, Satomi Kohno, Shigeru Saito, Russell H. Lowers, Yukiko Ogino, Naomi Fukuta, Yoshinao Katsu, Yasuhiko Ohta, Makoto Tominaga, Louis J. Guillette Jr, Taisen Iguchi

    Scientific Report   5   2015.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep18581

  • Androgen regulates Mafb expression through its 3’UTR during mouse urethral masculinization Reviewed International journal

    157 ( 2 )   844 - 857   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： http://dx.doi.org/10.1210/en.2015-1586

  • Nortestosterone-derived synthetic progestogens do not activate the progestogen receptor of Murray–Darling rainbowfish (Melanotaenia fluviatilis) but are potent agonists of androgen receptors alpha and beta Reviewed International journal

    163   97 - 101   2015.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Understanding the Molecular Basis for Differences in Responses of Fish Estrogen Receptor Subtypes to Environmental Estrogens Reviewed

    Saki Tohyama, Shinichi Miyagawa, Anke Lange, Yukiko Ogino, Takeshi Mizutani, Norihisa Tatarazako, Yoshinao Katsu, Masaru Ihara, Hiroaki Tanaka, Hiroshi Ishibashi, Tohru Kobayashi, Charles R. Tyler, Taisen Iguchi

    Environmental Science & Technology   49 ( 12 )   7439 - 7447   2015.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.est.5b00704

  • Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins Reviewed

    Shinichi Miyagawa, Anke Lange, Saki Tohyama, Yukiko Ogino, Takeshi Mizutani, Tohru Kobayashi, Norihisa Tatarazako, Charles R. Tyler, Taisen Iguchi

    Journal of Applied Toxicology   35 ( 3 )   302 - 309   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jat.3020

  • NMDA receptor activation upstream of methyl farnesoate signaling for short day-induced male offspring production in the water flea, Daphnia pulex Reviewed

    Kenji Toyota, Hitoshi Miyakawa, Katsushi Yamaguchi, Shuji Shigenobu, Yukiko Ogino, Norihisa Tatarazako, Shinichi Miyagawa, Taisen Iguchi

    BMC Genomics   16 ( 1 )   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12864-015-1392-9

  • Differential ligand selectivity of androgen receptors α and β from Murray-Darling rainbowfish (Melanotaenia fluviatilis) Reviewed International journal

    212   84 - 91   2015.2

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  • Targeted gene disruption by use of transcription activator-like effector nuclease (TALEN) in the water flea Daphnia pulex Reviewed International journal

    Chizue Hiruta, Yukiko Ogino, Tetsushi Sakuma, Kenji Toyota, Shinichi Miyagawa, Takashi Yamamoto, Taisen Iguchi

    BMC Biotechnology   14   95   2014.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Rapid Fluorescent Detection of (Anti)androgens with spiggin-gfp Medaka Reviewed International journal

    Environmental Science & Technology   48   10919 - 10928   2014.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Roles of ecdysteroids for progression of reproductive cycle in the fresh water crustacean Reviewed International journal

    Eri Sumiya, Yukiko Ogino, Hitoshi Miyakawa, Chizue Hiruta, Kenji Toyota, Shinichi Taisen, Taisen Iguchi

    Frontiers in Zoology   11   60   2014.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Essential roles of epithelial bone morphogenetic protein signaling during prostatic development Reviewed International journal

    Akiko Omori, Shinichi Miyagawa, Yukiko Ogino, Masayo Harada, Kenichiro Ishii, Yoshiki Sugimura, Hajime Ogino, Naomi Nakagata, Gen Yamada

    Endocrinology   155   2534 - 2544   2014.7

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  • Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor Reviewed

    Shinichi Miyagawa, Anke Lange, Ikumi Hirakawa, Saki Tohyama, Yukiko Ogino, Takeshi Mizutani, Yoshihiro Kagami, Teruhiko Kusano, Masaru Ihara, Hiroaki Tanaka, Norihisa Tatarazako, Yasuhiko Ohta, Yoshinao Katsu, Charles R. Tyler, Taisen Iguchi

    Environmental Science & Technology   48 ( 9 )   5254 - 5263   2014.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/es5002659

  • Di-n-butyl phthalate causes estrogenic effects in adult male Murray rainbowfish (Melanotaenia fluviatilis) Reviewed

    Harpreet Bhatia, Anupama Kumar, Yukiko Ogino, Adrienne Gregg, John Chapman, Mike J. McLaughlin, Taisen Iguchi

    Aquatic Toxicology   149   103 - 115   2014.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.aquatox.2014.01.025

  • Effects of the commercial antiandrogen flutamide on the biomarkers of reproduction in male Murray rainbowfish (Melanotaenia fluviatilis), Reviewed International journal

    Harpreet Bhatia, Anupama Kumar, Yukiko Ogino, Jun Do, Anrienne Gregg, John Chapman, Mike J. Mclaughlin, Taisen Iguchi

    Environmental Toxicology and Chemistry   33   1098 - 1107   2014.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors Reviewed

    Tomohiro Oka, Naoko Mitsui-Watanabe, Norihisa Tatarazako, Yuta Onishi, Yoshinao Katsu, Shinichi Miyagawa, Yukiko Ogino, Ryohei Yatsu, Satomi Kohno, Minoru Takase, Yukio Kawashima, Yasuhiko Ohta, Yasunobu Aoki, Louis J. Guillette, Taisen Iguchi

    Journal of Applied Toxicology   33 ( 9 )   991 - 1000   2013.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jat.2825

  • β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation Reviewed

    32 ( 29 )   3477 - 3482   2013.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    The Wnt/β-catenin signaling is essential for various organogenesis and is often implicated during tumorigenesis. Dysregulated β-catenin signaling is associated with the formation of endometrial adenocarcinomas (EACs), which is considered as the common form of endometrial cancer in women. In the current study, we investigate the downstream target of Wnt/β-catenin signaling in the uterine epithelia and the mechanism leading to the formation of endometrial hyperplasia. We report that conditional ablation and activation of β-catenin in the uterine epithelia lead to aberrant epithelial structures and endometrial hyperplasia formation, respectively. We demonstrate that β-catenin regulates Foxa2 with its candidate upstream region for the uterine epithelia. Furthermore, knockdown of Foxa2 leads to defects in cell cycle regulation, suggesting a possible function of Foxa2 in the control of cell proliferation. We also observe that β-catenin and Foxa2 expression levels are augmented in the human specimens of complex atypical endometrial hyperplasia, which is considered to have a greater risk of progression to EACs. Thus, our study indicates that β-catenin regulates Foxa2 expression, and this interaction is possibly essential to control cell cycle progression during endometrial hyperplasia formation. Altogether, the augmented expression levels of β-catenin and Foxa2 are essential features during the formation of endometrial hyperplasia.

    DOI： 10.1038/onc.2012.376

  • Molecular cloning of doublesex genes of four cladocera (water flea) species Reviewed

    Kenji Toyota, Yasuhiko Kato, Masaru Sato, Naomi Sugiura, Shinichi Miyagawa, Hitoshi Miyakawa, Hajime Watanabe, Shigeto Oda, Yukiko Ogino, Chizue Hiruta, Takeshi Mizutani, Norihisa Tatarazako, Susanne Paland, Craig Jackson, John K. Colbourne, Taisen Iguchi

    BMC Genomics   14 ( 1 )   2013.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1471-2164-14-239

  • Effects of 17β-trenbolone on Eastern and Western mosquitofish (Gambusia holbrooki and G. affinis) anal fin growth and gene expression patterns Reviewed

    128-129   163 - 170   2013.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    The Eastern and Western mosquitofish (Gambusia holbrooki and G. affinis) are potential bioindicator organisms for endocrine disruptors. Male mosquitofish have an elongated anal fin (gonopodium) used for internal fertilization whose formation is driven by androgens. Normal female mosquitofish have a normal, rounded anal fin which undergoes elongation into a gonopodium structure when female mosquitofish are exposed to androgenic chemicals. Significant issues with using mosquitofish as a bioindicator include the lack of knowledge on how anal fin growth in females corresponds to endpoints relevant to biological integrity and the lack of information on the molecular pathways that regulate anal fin growth. The objectives of this study were to understand how androgen-induced anal fin elongation relates to changes in endpoints related to the female reproductive system and to understand how anal fin elongation occurs in androgen-exposed female mosquitofish. To achieve these objectives, adult female G. holbrooki were exposed to a vehicle control or one of three doses of the androgen 17β-trenbolone (TB) at nominal concentrations of 0.1, 1 or 10 μg TB/L. Anal fin measurements were taken and livers were used for quantitative polymerase chain reaction analysis of vitellogenin (vtg) mRNA expression at multiple time points. 10 μg TB/L induced anal fin elongation after 7 days of treatment (one-way ANOVA, p< 0.05) as did 0.1 and 1 μg TB/L at later time points (one-way ANOVA, p< 0.05). 10 μg TB/L significantly reduced hepatic vtg gene expression at all time points assessed (one-way ANOVA, p< 0.05). There was no correlation between anal fin elongation levels and vtg gene expression (Spearman's ρ, p> 0.05). In a separate experiment, female G. holbrooki and G. affinis were exposed to the vehicle control or 1 μg TB/L. Anal fins were used for qualitative gene expression analysis of the genes sonic hedgehog (shh), muscle segment homeobox C (msxC), and fibroblast growth factor receptor 1 (fgfr1) by in situ hybridization. Shh was expressed in the distal tip of the gonopodium while msxC and fgfr1 were more widely expressed along the same anal fin rays during androgen exposure. These data provide insight into the molecular pathways involved in anal fin elongation and pave the way for future work toward developing the mosquitofish into a bioindicator organism for endocrine disruptors.

    DOI： 10.1016/j.aquatox.2012.12.007

  • A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans Reviewed

    Hitoshi Miyakawa, Kenji Toyota, Ikumi Hirakawa, Yukiko Ogino, Shinichi Miyagawa, Shigeto Oda, Norihisa Tatarazako, Toru Miura, John K. Colbourne, Taisen Iguchi

    Nature Communications   4   2013

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ncomms2868

  • Gene expression profiles in the testis associated with testis-ova in adult Japanese medaka (Oryzias latipes) exposed to 17α-ethinylestradiol Reviewed

    87 ( 7 )   668 - 674   2012.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    The occurrence of oocytes in the testis (testis-ova) of several fish species is often associated with exposure of estrogenic chemicals. However, induction mechanisms of the testis-ova remain to be elucidated. To develop marker genes for detecting testis-ova in the testis, adult male medaka were exposed to nominal concentration of 100ngL -1 of 17α-ethinylestradiol (EE2) for 3-5weeks, and 800ng estradiol benzoate (EB) for 3weeks (experiment I), and a measured concentration of 20ngL -1 EE2 for 1-6weeks (experiment II). Histological analysis was performed for the testis, and microarray analyses were performed for the testis, liver and brain. Microarray analysis in the estrogen-exposed medaka liver showed vitellogenin and choriogenin as estrogen responsive genes. Testis-ova were induced in the testis after 4weeks of exposure to 100ngL -1 EE2, 3weeks of exposure to 800ngEB, and 6weeks of exposure to 20ngL -1 EE2. Microarray analysis of estrogen-exposed testes revealed up-regulation of genes related to zona pellucida (ZP) and the oocytes marker gene, 42Sp50. Using quantitative RT-PCR we confirmed that Zpc5 gene can be used as a marker for the detection of testis-ova in male medaka.

    DOI： 10.1016/j.chemosphere.2011.12.047

  • Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring Reviewed

    Anke Lange, Yoshinao Katsu, Shinichi Miyagawa, Yukiko Ogino, Hiroshi Urushitani, Tohru Kobayashi, Toshiaki Hirai, Janice A. Shears, Masaki Nagae, Jun Yamamoto, Yuta Ohnishi, Tomohiro Oka, Norihisa Tatarazako, Yasuhiko Ohta, Charles R. Tyler, Taisen Iguchi

    Aquatic Toxicology   109   250 - 258   2012.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.aquatox.2011.09.004

  • Retinoic Acid Signaling Regulates Sonic Hedgehog and Bone Morphogenetic Protein Signalings During Genital Tubercle Development Reviewed

    Liqing Liu, Kentaro Suzuki, Naomi Nakagata, Kenichiro Mihara, Daisuke Matsumaru, Yukiko Ogino, Kenta Yashiro, Hiroshi Hamada, Zhonghua Liu, Sylvia M. Evans, Cathy Mendelsohn, Gen Yamada

    Birth Defects Research Part B - Developmental and Reproductive Toxicology   95 ( 1 )   79 - 88   2012.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/bdrb.20344

  • Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation Reviewed

    Aki Murashima, Shinichi Miyagawa, Yukiko Ogino, Hisayo Nishida-Fukuda, Kimi Araki, Takahiro Matsumoto, Takehito Kaneko, Kazuya Yoshinaga, Ken Ichi Yamamura, Takeshi Kurita, Shigeaki Kato, Anne M. Moon, Gen Yamada

    Endocrinology   152 ( 4 )   1640 - 1651   2011.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1210/en.2010-1121

  • Sonoporation for gene transfer into embryos Reviewed

    Sho Ohta, Yukiko Ogino, Kentro Suzuki, Mika Kamimura, Katsuro Tachibana, Gen Yamada

    Cold Spring Harbor Protocols   6 ( 3 )   2011.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1101/pdb.prot5581

  • Sonoporation in developmental biology

    Sho Ohta, Kentaro Suzuki, Shinichi Miyagawa, Yukiko Ogino, Mylah Villacorte, Yoshihiro Wada, Gen Yamada

    Electroporation and Sonoporation in Developmental Biology   317 - 326   2009

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    Language：English  

    DOI： 10.1007/978-4-431-09427-2_27

  • Gene transduction by sonoporation Reviewed

    Sho Ohta, Kentaro Suzuki, Yukiko Ogino, Shinichi Miyagawa, Aki Murashima, Daisuke Matsumaru, Gen Yamada

    Development Growth and Differentiation   50 ( 6 )   517 - 520   2008.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1440-169X.2008.01026.x

  • Gene expression analyses on embryonic external genitalia Identification of regulatory genes possibly involved in masculinization processes Reviewed

    Hisayo Nishida, Shinichi Miyagawa, Daisuke Matsumaru, Yoshihiro Wada, Yoshihiko Satoh, Yukiko Ogino, Shinji Fukuda, Taisen Iguchi, Gen Yamada

    Congenital Anomalies   48 ( 2 )   63 - 67   2008.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1741-4520.2008.00180.x

  • Positive regulation of steroidogenic acute regulatory protein gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis Reviewed

    Hisayo Nishida, Shinichi Miyagawa, Maxence Vieux-Rochas, Monica Morini, Yukiko Ogino, Kentaro Suzuki, Naomi Nakagata, Hueng Sik Choi, Giovanni Levi, Gen Yamada

    Endocrinology   149 ( 5 )   2090 - 2097   2008.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1210/en.2007-1265

  • Cloning and expression analysis of androgen receptor gene in chicken embryogenesis Reviewed

    Hironori Katoh, Yukiko Ogino, Gen Yamada

    FEBS Letters   580 ( 6 )   1607 - 1615   2006.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.febslet.2006.01.093

  • Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice Reviewed

    Hidenao Ogi, Kentaro Suzuki, Yukiko Ogino, Mika Kamimura, Mami Miyado, Xu Ying, Zunyi Zhang, Masanori Shinohara, Yiping Chen, Gen Yamada

    Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology   284 ( 1 )   424 - 430   2005.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ar.a.20180

  • The morphological and histological characters of the male external genitalia of the house musk shrew, Suncus murinus Reviewed

    Mami Kamikawa-Miyado, Hidenao Ogi, Yukiko Ogino, Hironori Katoh, Kentaro Suzuki, Masanori Uemura, Junzoh Kitoh, Sen Ichi Oda, Gen Yamada

    Zoological Science   22 ( 4 )   463 - 468   2005.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2108/zsj.22.463

  • Androgen dependent development of a modified anal fin, gonopodium, as a model to understand the mechanism of secondary sexual character expression in vertebrates Reviewed

    Yukiko Ogino, Hironori Katoh, Gen Yamada

    FEBS Letters   575 ( 1-3 )   119 - 126   2004.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.febslet.2004.08.046

    Repository Public URL： https://hdl.handle.net/2324/7173448

  • Regulation of outgrowth and apoptosis for the terminal appendage External genitalia: Development by concerted actions of BMP signaling Reviewed

    Kentaro Suzuki, Daniel Bachiller, Yi Ping P. Chen, Mami Kamikawa, Hidenao Ogi, Ryama Haraguchi, Yukiko Ogino, Yasuhiro Minami, Yuji Mishina, Kyung Ahn, E. Bryan Crenshaw, Gen Yamada

    Development (Cambridge)   130 ( 25 )   6209 - 6220   2003.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1242/dev.00846

  • Embryonic development of mouse external genitalia Insights into a unique mode of organogenesis Reviewed

    Kentaro Suzuki, Yukiko Ogino, Ryutaro Murakami, Yoshihiko Satoh, Daniel Bachiller, Gen Yamada

    Evolution and Development   4 ( 2 )   133 - 141   2002.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1046/j.1525-142X.2002.01061.x

  • External genitalia formation Role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium Reviewed

    Yukiko Ogino, Kentaro Suzuki, Ryuma Haraguchi, Yoshihiko Satoh, Pascal Dolle, Gen Yamada

    Annals of the New York Academy of Sciences   948   13 - 31   2001.1

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Books

  • 遺伝子から解き明かす魚の不思議な世界

    神田真司　高木亙　矢野十織　二階堂雅人　安齋賢　渡邊壮一　石川麻乃　小橋常彦　池永隆徳　佐野香織　飯田敦夫　竹花佑介　荻野由紀子　小林 靖尚　野津了（ Role： Joint author）

    一色出版  2019.8 

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    Language：Japanese   Book type：General book, introductory book for general audience

  • Handbook of Hormones - Comparative Endocrinology for Basic and Clinical Research

    （ Role： Joint author）

    2021.11 

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    Language：English   Book type：Scholarly book

  • Medaka Biology, Management, an Experimental Protocols, Volume　2

    Chief Editor: Kenji Murata, Masato Kinoshita, Kiyoshi Naruse Editors: Minoru Tanaka, Yasuhiro Kamei Chapter9分担執筆（Yukiko Ogino, Taisen Iguchi)（ Role： Joint author）

    2020.1 

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    Responsible for pages：Chapter9（p271-279）担当執筆   Language：Japanese   Book type：Scholarly book

  • Diversified Sex Characteristics Developments in Teleost Fishes: Implication for Evolution of Androgen Receptor (AR) Gene Function (Zebrafish, Medaka, an Other Small Fishes；New model Animals in Biology, Medicine, and Beyond)

    （ Role： Joint author）

    2018.11 

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    Language：English   Book type：Scholarly book

  • 動物学の百科事典

    日本動物学会 編 （分担執筆）泌尿生殖器官の発生ーオスとメスができる仕組み　村嶋亜紀、荻野由紀子（ Role： Joint author）

    丸善出版  2018.9 

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    Language：Japanese   Book type：Scholarly book

  • External genitalia development A model system to study organogenesis

    K. Suzuki, H. Nishida, S. Ohta, Y. Satoh, Y. Xu, Y. Zhang, Y. Wada, Yukiko Ogino, N. Nakagata, T. Ohba, G. Yamada（ Role： Joint author）

    CRC Press  2016.4 

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    Responsible for pages：263-278   Language：English   Book type：Scholarly book

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Presentations

  • 魚類におけるアンドロゲン依存的な二次性徴形質の獲得進化の分子基盤 Molecular basis for evolutionary diversification of androgen-dependent sexual characteristics in teleost

    ＠荻野由紀子

    第46回日本分子生物学会年会シンポジウム  2023.12 

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    Event date： 2023.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：神戸国際会議場   Country：Japan  

  • 魚類の多彩な二次性徴形質の獲得進化の分子基盤 Invited

    ＠荻野由紀子

    第４７回日本比較内分泌学会大会及びシンポジウム  2023.11 

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    Event date： 2023.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：九州大学西新プラザ   Country：Japan  

  • アンドロゲン受容体の重複進化による魚類の性的二型形質の多様化 Diversification of sexually dimorphic traits responsible for the gene duplication of androgen receptor in teleost fish Invited

    ＠荻野由紀子

    日本動物学会第94回山形大会シンポジウム  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：山形大学小白川キャンパス   Country：Japan  

  • アンドロゲン受容体の重複進化による魚類の性的二型形質の多様化 Invited

    ＠荻野由紀子

    NBRP主催シンポジウム「バイオリソースで解決する21世紀の社会課題」  2023.2 

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    Event date： 2023.2

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：一橋大学   Country：Japan  

  • アンドロゲン受容体の重複と機能分化から見る魚類の性的二型形質の多様化 Invited

    ＠荻野由紀子

    2022年度日本魚類学会シンポジウム  2022.9 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大阪公立大学杉本キャンパス   Country：Japan  

  • Molecular basis of androgen dependent sex characteristics development and evolution with teleost fishes as model species Invited

    Yukiko Ogino, Satoshi Ansai, Hirotaka Sakamoto, Eiji Watanabe, Kiyoshi Naruse and Taisen Iguchi

    2019.12 

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    Event date： 2019.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 魚類の多彩な繁殖様式を導く二次性徴形質の多様化と進化の分子基盤Molecular basis of sex characteristics development and evolution in teleost fishes Invited

    荻野由紀子、坂本浩隆、渡辺英治、安齋 賢、井口泰泉

    日本動物学会第90回大阪大会  2019.9 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大阪市立大学大学   Country：Japan  

    真骨魚類は爆発的に適応・多様化して繁栄を遂げており、その共通祖先で起きた全ゲノム 重複後の遺伝子の再編成・新機能の獲得と、多様な形質発現との関連性が注目されている。
    中でも雄に特徴的な求愛・闘争行動や装飾的な雄性形質の進化は、多彩な繁殖戦略を可能とし、真骨魚類の繁栄をもたらした重要な要因と考えられる。しかし、多様な雄性形質発現の遺伝的背景、分子機構の詳細は多くが未解明のままである。
    アンドロゲンは脊椎動物において、二次性徴を誘導し、“雄性形質”を特徴付けている。それ故、アンドロゲンは、性決定、生殖腺の分化に続く、個体の性の確立の最終段階を担う実行因子である。哺乳類ではアンドロゲン受容体（AR）遺伝子は1分子種であり、脳神経系や生殖器、外部形態の二次性徴など多面的な発現を示すことから、それ自体の変異が多器官に影響を及ほすため、遺伝的な拘束を強く受けていると考えられる。真骨魚類では、真骨魚類の系統で特異的に起きたゲノム倍数化に伴い、真骨魚類ではARα、ARβの2分子種（ARα、ARβ）に重複したことで拘束を回避し、重要な生殖機能については重複遺伝子の補償作用から冗長性を確保しつつ、新たな機能を獲得したことか予想される。
    本研究では、メダカAR変異体を用いて、AR遺伝子の重複に伴う新機能獲得と、形態・神経機能における二次性徴形質の多様化との関連性を解析するとともに、カダヤシの尻ヒレから交接器（gonopodium:GP）への移行、ソードテールフィッシュの性選択形質である尾ビレの伸長との比較解析から、アンドロゲンによって誘導される多様性の根源的な理解を深めようとしている。
    これまでに、ARの分子進化解析から、進化速度の速いARαは、リガンド非依存的な核局在や、ARβ及び四肢動物のARより極めて高い転写活性化能を示すユニークな ARとして真骨魚類の系統で進化してきたことを報告した。この機能的に異なるAR遺伝子の出現、それに伴うシグナリングネットワークの拡充が、真骨魚類の多様な二次性徴を生み出す一つの重要な原動力（遺伝的背景）となった可能性が考えられる。AR遺伝子変異体メダカを用いた表現型解析から、ARα/βダブル変異体オスは自然交配では繁殖できないが、ARα, ARβそれぞれの変異体オスは繁殖可能であり、外部形態・脳神経機能に果たす役割に相違を示すなど、AR遺伝子重複の生物学的意義が明らかとなりつつある。現在さらに、ARα, ARβそれぞれの生体内におけるタンパクレベルの局在や発現動態の解析から、ARパラログの標的細胞の同定、組織特異的な機能発現の詳細について解析を進めている。また、上記真骨魚類の雄性形質発現過程の比較解析から、二次性徴発現に共通の分子機構が存在していることを見出したので合わせて議論したい。

  • Diversification of androgen receptor function underlies secondary sex characteristics development of teleost fishes. Invited International conference

    Yukiko Ogino, Hirotaka Sakamoto, Eiji Watanabe and Taisen Iguchi

    4th Strategic Meeting for Medaka Research,3rd Regional Fish Meeting  2018.4 

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    Event date： 2018.4

    Language：English   Presentation type：Oral presentation (general)  

    Country：Germany  

  • 真骨魚類をモデルとしたアンドロゲンによる雄性形質発現・生理作用の分子機構解析 Invited

    荻野由紀子、坂本浩隆、井口泰泉

    2017年度生命科学系学会合同年次大会（ConBio2017）  2017.12 

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    Event date： 2017.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：神戸国際会議場（兵庫県神戸市）   Country：Japan  

  • Evolutionary diversification of androgen dependent sex characteristics development in teleost fishes. Invited International conference

    The 22nd International Congress of Zoology  2016.11 

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    Event date： 2017.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 魚類の多様な雄性形質発現の分子機構 Invited

    荻野 由紀子, 井口泰泉

    第26回日本行動神経内分泌研究会  2017.4 

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    Event date： 2017.4

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：牛窓研修センター　カリヨンハウス、岡山県瀬戸内市   Country：Japan  

  • 真骨魚類の多彩な二次性徴形質発現の分子機構 “メダカ、卵胎生魚類カダヤシ、ソードティルフィッシュを用いた比較解析” Invited

    荻野 由紀子

    ユニークな少数派実験動物を扱う若手が最先端アプローチを勉強する会  2016.8 

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    Event date： 2016.8

    Language：Japanese  

    Venue：自然科学研究機構　岡崎コンファレンスセンター   Country：Japan  

  • Functional and evolutionary analyses of androgen receptor gene in teleost fishes: Molecular basis of diversified sex characteristics development

    2016.8 

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    Event date： 2016.8

    Language：English  

    Country：Japan  

  • ザイモザン刺激による免疫応答はタイリクバラタナゴの婚姻色の発達を抑制する

    ＠笠元、＠荻野由紀子、＠長澤貴宏、＠杣本智軌、＠中尾実樹

    第４７回日本比較内分泌学会大会及びシンポジウム  2023.11 

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    Event date： 2023.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：九州大学西新プラザ   Country：Japan  

  • 二次性徴発現の組織特異性を決めるメカニズムとは？

    ＠荻野由紀子

    第８回ユニーク会  2023.9 

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    Event date： 2023.9

    Language：Japanese  

    Venue：鹿児島大学郡元キャンパス   Country：Japan  

  • Regulation of regional development of androgen-dependent secondary sex characteristics

    2021.12 

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    Event date： 2021.12

    Language：Japanese  

    Country：Japan  

  • トリブチルスズ結合タンパク質の性ステロイドに対する結合能とその作用緩和能

    博多響、高井優生、李在萬、太田耕平、荻野由紀子、島崎洋平、大嶋雄治 　学生:３人, 学生以外:4人

    環境ホルモン学会研究発表会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン   Country：Japan  

  • インドネシアメダカのオスにおける臀鰭伸長の分子基盤

    岡本啓吾、安齋賢、荻野由紀子 学生：1人, 学生以外2人

    第９２回日本動物学会年会  2021.9 

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    Event date： 2021.9

    Language：Japanese  

    Venue：オンライン   Country：Japan  

  • メダカのアンドロゲン依存的な性的二型発現の制御機構：RNA-seqとATAC-seqの複合解析

    荻野由紀子、安齋 賢、井口泰泉

    第54 回日本発生生物学会年会  2021.6 

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    Event date： 2021.6

    Language：Japanese  

    Venue：オンライン   Country：Japan  

  • Molecular mechanism of the tissue specific sex characteristics development in medaka、

    第43回日本分子生物学会年会  2020.12 

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    Event date： 2021.5

    Language：Japanese  

    Venue：オンライン   Country：Japan  

  • Functional analysis of two distinct paralogs of androgen receptor for the sex characteristics development in medaka

    Yukiko Ogino, Hirotaka Sakamoto, Eiji Watanabe, Satoshi Ansai, Kiyoshi Naruse and Taisen Iguchi

    52th Annual Meeting of the Japanese Society of Developmental Biologists  2019.5 

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    Event date： 2019.5

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Approach to establishing a knock-in system by using TAL-PITCH in the water flea Daphnia pulex.

    2016.9 

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    Event date： 2016.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

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MISC

  • Gene Duplication of Androgen Receptor As An　Evolutionary Driving Force Underlying the Diversity of　Sexual Characteristics in Teleost Fishes Reviewed

    2024.2

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    Sexual dimorphism allows species to meet their fitness optima based on the physiological availability of each sex. Although intralocus sexual conflict appears to be a genetic constraint for the evolution of sex-specific traits, sex-linked genes and the regulation of sex steroid hormones contribute to resolving this conflict by allowing sex-specific developments. Androgens and their receptor, androgen receptor (Ar), regulate male-biased phenotypes. In teleost fish, ar ohnologs have emerged as a result of teleost-specific whole genome duplication (TSGD). Recent studies have highlighted the evolutionary differentiation of ar ohnologs responsible for the development of sexual characteristics, which sheds light on the need for comparative studies on androgen regulation among different species. In this review, we discuss the importance of ar signaling as a regulator of male-specific traits in teleost species because teleost species are suitable experimental models for comparative studies owing to their great diversity in male-biased morphological and physiological traits. To date, both in vivo and in vitro studies on teleost ar ohnologs have shown a substantial influence of ars as a regulator of male-specific reproductive traits such as fin elongation, courtship behavior, and nuptial coloration. In addition to these sexual characteristics, ar substantially influences immunity, inducing a sex-biased immune response. This review aims to provide a comprehensive understanding of the current state of teleost ar studies and emphasizes the potential of teleost fishes, given their availability, to find molecular evidence that give rise to spectacular diversity among fish species.

  • Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR

    Yukiko Ogino, Saki Tohyama, Satomi Kohno, Kenji Toyota, Gen Yamada, Ryohei Yatsu, Tohru Kobayashi, Norihisa Tatarazako, Tomomi Sato, Hajime Matsubara, Anke Lange, Charles R. Tyler, Yoshinao Katsu, Taisen Iguchi, Shinichi Miyagawa

    Journal of Steroid Biochemistry and Molecular Biology   2018.11

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： 10.1016/j.jsbmb.2018.06.002

  • アンドロゲン受容体の重複進化による二次性徴形質の多様化　魚類の雄の装飾的なかたちや求愛行動の進化の原動力

    岡本 啓吾, 笠 元, 荻野 由紀子

    化学と生物   62 ( 7 )   350 - 359   2024.7   （ ISSN:0453-073X ）

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    Language：Japanese   Publisher：(公社)日本農芸化学会  

  • メダカの　"オスらしさ"の秘密〜アンドロゲン受容体と多様な二次性徴形質の進化について〜

    ＠岡本啓吾、@荻野由紀子

    2024.5

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    Language：Japanese  

  • Regulation of masculinization Androgen signalling for external genitalia development

    Shoko Matsushita, Kentaro Suzuki, Aki Murashima, Daiki Kajioka, Alvin Resultay Acebedo, Shinichi Miyagawa, Ryuma Haraguchi, Yukiko Ogino, Gen Yamada

    Nature Reviews Urology   2018.6

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    Language：English  

    DOI： 10.1038/s41585-018-0008-y

Professional Memberships

  • Japan Society of Endocrine Disrupter Research

  • Japanese Society of Scientific Fisheries

  • Japanese society of developmental biologists

  • The Molecular Biology Society of Japan

  • Zoological Society of Japan

  • Japan Society for Comparative Endocrinology

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Committee Memberships

  • Steering committee member   Domestic

    2023.1 - 2024.12   

  • 日本比較内分泌学会   学術企画委員会委員   Domestic

    2023.1 - 2024.12   

  • 日本比較内分泌学会   2023年度日本比較内分泌学会及びシンポジウム大会長   Domestic

    2022.6 - 2023.12   

  • Steering committee member   Domestic

    2021.1 - 2022.12   

  • 日本比較内分泌学会   若手交流企画委員会委員長   Domestic

    2021.1 - 2022.12   

  • Steering committee member   Foreign country

    2020.4 - 2025.3   

  • Councilor   Domestic

    2018.5 - 2024.6   

  • 環境ホルモン学会   評議員   Domestic

    2018.5 - 2024.6   

  • 日本動物学会   男女共同参画委員   Domestic

    2016.9 - 2025.9   

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Academic Activities

  • 運営委員 International contribution

    １８th　Internationnal Zebrafish Conference (IZFC)  （ 京都府（京都市） ） 2024.8

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    Type：Competition, symposium, etc. 

  • 大会長

    第47回日本比較内分泌学会大会及びシンポジウム 九州大会  （ 九州大学西新プラザ ） 2023.11

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    Type：Competition, symposium, etc. 

    Number of participants：150

  • 世話人

    第８回ユニーク回研究発表会  （ 鹿児島大学理学部 ） 2023.9

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    Type：Competition, symposium, etc. 

    Number of participants：50

  • 運営委員

    （ つくば国際会議場 ） 2021.9

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    Type：Competition, symposium, etc. 

    Number of participants：100

  • Scientific Report International contribution

    2014.10 - 2018.9

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    Type：Academic society, research group, etc. 

Other

  • 第46回日本分子生物学会年会（MBSJ2023）にてシンポジウム『水棲動物のゲノム科学で進化の謎を紐解く』 のオーガナイザーをつとめた。

    2023.12

  • Basic biology of human infant diseases: From embryogenesis to endocrine system

    2018.12

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    成育疾患には遺伝的要因、環境要因、内分泌系の異常など内・外的要因が複合的に関連しており、その発症時期や表現型は多岐にわたる。しかし組織・細胞レベルで紐解くと共通性を見ることが出来る。本ワークショップでは、増殖因子や内分泌因子の役割を中心に、細胞レベルでの解析から個体レベルでの表現型解析まで、様々な階層の疾患・器官形成原理について多様な生物種を用いて包括的に研究を進める若手研究者を集め、成育疾患発症の根本原理を議論したい。

Research Projects

  • ゲノム内分泌学から探る繁殖行動戦略の収斂進化機構

    Grant number：24K21992  2024.6 - 2027.3

    科学研究費助成事業  挑戦的研究(萌芽)

    小北 智之, 荻野 由紀子

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    Grant type：Scientific research funding

    野生動物が示す多様な本能行動の進化機構の解明は大きな科学的挑戦である．野生動物の多様な本能行動の中で，繁殖関連の行動発現は個体の適応度に直結するため，生態・社会的条件と関連した収斂進化的な多様性創出が認められることが多い．自然界における繁殖関連行動の収斂進化は，いったいどのような機能遺伝変異によって達成されてきたのだろうか．また，行動形質の収斂性の背後にある進化遺伝基盤のレパートリーは実際どの程度多様なのだろうか．本研究では，トゲウオ科魚類に認められる雄の繁殖縄張り行動発現の集団間・近縁種間変異に焦点を当て，縄張り行動発現の収斂進化の遺伝基盤とそのレパートリーの多様性を実証的に描き出す．

    CiNii Research

  • 種間比較から紐解く形態的な二次性徴形質の多様化機構の解明

    Grant number：24K02063  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 空間情報と1細胞解析の統合による魚類生殖腺の性的可塑性を制御する分子機構の解明

    Grant number：22H00386  2023 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 二次性徴の進化基盤

    2023 - 2024

    第55回内藤記念科学奨励金・研究助成

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    Authorship：Principal investigator  Grant type：Contract research

  • 種に固有の二次性徴形質の進化基盤

    2022

    数理・データサイセンスに関する教育・研究支援プログラム

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 魚類の性的二型形質発現の進化機構

    2022

    令和3年度研究補助者雇用支援（短期）

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish

    2022

    　 More details

    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • アンドロゲンによる二次性徴発現機構の解明

    2021

    令和3年度研究補助者雇用支援（短期）

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 二次性徴の性スペクトラム『アンドロゲンによる組織特異性とサイズ調節の分子機構』

    Grant number：20H04928  2020 - 2021

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • アンドロゲンによる二次性徴発現機構の解明

    2020

    令和２年度研究補助者雇用支援（短期）

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • アンドロゲン受容体の機能分化からみる多様な雄性形質発現の基本原理

    Grant number：19K06741  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • １細胞解析系と性転換モデルによる魚類生殖腺の性的可塑性に関する分子機構の解明

    Grant number：19H03049  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • アンドロゲンによる二次性徴発現機構の解明

    2019

    平成３１年度研究補助者雇用支援（短期）

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 魚類リポカリンタンパク質―性分化機構を中心とした機能の解明

    2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 二次性徴を決定付けるクロマチン動態の解明

    2018 - 2019

    アステラス病態代謝研究会研究助成金

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    Authorship：Principal investigator  Grant type：Contract research

  • 魚類を用いた二次性徴発現と個体認知・情動制御システムの解明

    2017 - 2019

    内藤記念女性研究者研究助成金

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    Authorship：Principal investigator  Grant type：Contract research

  • アンドロゲン応答形質の多様化と適応の分子機構・内分泌かく乱化学物質モニタリング生物の開発

    2016 - 2018

    女性枠設定による教員採用・研究者養成システム(第II期）

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 魚類のアンドロゲン応答形質が個体間認識・相互作用に果たす役割についての進化学的解明

    2016

    平成２８年度「出産・育児復帰者支援」

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 原点「ミネラルコルチコイドの普遍的機構」から俯瞰するステロイドホルモンの機能分化

    Grant number：15H04395  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • アンドロゲン応答形質の多様化と適応の分子生物学的基盤

    Grant number：15K07138  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 環境依存型性決定研究のモデル化とメカニズム解析

    Grant number：15H04396  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

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Educational Activities

  • To develop the ability of the creative thinking that is necessary to solve the global environmental problem, I teach a wide variety of biological research areas of biological sciences, such as ecology, environmental science, evolutionary biology, and molecular biology.
    In education and research activities for graduate students, I have focused on the hormonal regulatory mechanism of sex characteristics development, which is the basis of biodiversity.

Class subject

  • Technical Communication 3-II

    2024.6 - 2024.7   Summer quarter

  • 進化生物学

    2024.4 - 2024.6   Spring quarter

  • Technical Communication 3-I

    2024.4 - 2024.6   Spring quarter

  • Systematics, Diversity and Evolution Ⅰ

    2024.4 - 2024.6   Spring quarter

  • BBEP M-II；Molecular biology

    2023.12 - 2024.2   Winter quarter

  • Basic Ecology and Biology Ⅱ

    2023.12 - 2024.2   Winter quarter

  • Ecological Developmental Biology Ⅱ

    2023.12 - 2024.2   Winter quarter

  • BBEP M-I；Molecular biology

    2023.10 - 2023.12   Fall quarter

  • Basic Ecology and Biology I

    2023.10 - 2023.12   Fall quarter

  • Ecological Developmental Biology Ⅰ

    2023.10 - 2023.12   Fall quarter

  • Systematics, Diversity and Evolution Ⅱ

    2023.6 - 2023.8   Summer quarter

  • 進化生物学

    2023.4 - 2023.6   Spring quarter

  • Technical Communication 3

    2023.4 - 2023.6   Spring quarter

  • Systematics, Diversity and Evolution Ⅰ

    2023.4 - 2023.6   Spring quarter

  • Ecological Developmental Biology Ⅱ

    2022.12 - 2023.2   Winter quarter

  • Basic Ecology and Biology Ⅱ

    2022.12 - 2023.2   Winter quarter

  • Ecological Developmental Biology Ⅰ

    2022.10 - 2022.12   Fall quarter

  • Bioresource and Bioenvironment Experiments and Practice 2

    2022.10 - 2022.12   Fall quarter

  • Basic Ecology and Biology I

    2022.10 - 2022.12   Fall quarter

  • Systematics, Diversity and Evolution

    2022.4 - 2022.9   First semester

  • 進化生物学

    2022.4 - 2022.6   Spring quarter

  • 動物・海洋生物科学特別研究第一

    2021.12 - 2022.2   Winter quarter

  • 動物・海洋生物科学プロジェクト演習

    2021.12 - 2022.2   Winter quarter

  • 動物・海洋生物科学演習第一

    2021.12 - 2022.2   Winter quarter

  • Technical communication 2

    2021.10 - 2022.3   Second semester

  • Population Biology and Ecology

    2021.10 - 2022.3   Second semester

  • Basic Ecology

    2021.10 - 2022.3   Second semester

  • Bioresource and Bioenvironment Experiments and Practice 2

    2021.10 - 2022.3   Second semester

  • 動物・海洋生物科学特別研究第一

    2021.10 - 2021.12   Fall quarter

  • 動物・海洋生物科学プロジェクト演習

    2021.10 - 2021.12   Fall quarter

  • 動物・海洋生物科学演習第一

    2021.10 - 2021.12   Fall quarter

  • 演技技法I

    2021.6 - 2021.8   Summer quarter

  • Population Biology and Ecology

    2021.4 - 2021.9   First semester

  • Basic Ecology

    2021.4 - 2021.9   First semester

  • 進化生物学

    2021.4 - 2021.6   Spring quarter

  • 動物・海洋生物科学特別研究第一

    2021.4 - 2021.6   Spring quarter

  • Technical communication 2

    2020.10 - 2021.3   Second semester

  • Systematics, Diversity and Evolution

    2020.10 - 2021.3   Second semester

  • Bioresource and Bioenvironment Experiments and Practice 2

    2020.10 - 2021.3   Second semester

  • Basic Ecology

    2020.4 - 2020.9   First semester

  • Population Biology and Ecology

    2020.4 - 2020.9   First semester

  • 進化生物学

    2020.4 - 2020.6   Spring quarter

  • 進化生物学

    2020.4 - 2020.6   Spring quarter

  • Technical communication 2

    2019.10 - 2020.3   Second semester

  • Systematics, Diversity and Evolution

    2019.10 - 2019.12   Fall quarter

  • Bioresource and Bioenvironment Experiments and Practice 2

    2019.10 - 2019.12   Fall quarter

  • Population Biology and Ecology

    2019.4 - 2019.6   Spring quarter

  • Basic Ecology

    2019.4 - 2019.6   Spring quarter

  • Technical communication 2

    2018.10 - 2019.3   Second semester

  • Systematics, Diversity and Evolution

    2018.10 - 2018.12   Fall quarter

  • Bioresource and Bioenvironment Experiments and Practice 2

    2018.10 - 2018.12   Fall quarter

  • Basic Ecology

    2018.4 - 2018.6   Spring quarter

  • Population Biology and Ecology

    2018.4 - 2018.6   Spring quarter

  • Introductory Biology

    2018.4 - 2018.6   Spring quarter

  • Technical Communication 2

    2017.10 - 2018.3   Second semester

  • Systematics, Diversity and Evolution

    2017.10 - 2018.3   Second semester

  • Bioresource and Bioenvironment Experiments and Practice 2

    2017.10 - 2018.3   Second semester

  • Special Lecture on Advanced Topics of Agriculture 1

    2017.4 - 2017.9   First semester

  • Basic Ecology

    2017.4 - 2017.9   First semester

  • Population Biology and Ecology

    2017.4 - 2017.9   First semester

  • Introductory Biology

    2017.4 - 2017.9   First semester

  • Technical Communication 2

    2016.10 - 2017.3   Second semester

  • Bioresource and Bioenvironment Experiments and Practice 2

    2016.10 - 2017.3   Second semester

  • Systematics Diversity and Evolution

    2016.10 - 2017.3   Second semester

  • Special Lecture on Advanced Topics of Agriculture 1

    2016.10 - 2017.3   Second semester

  • Population Biology and Ecology

    2016.4 - 2016.9   First semester

  • Basic Ecology

    2016.4 - 2016.9   First semester

  • Introductory Biology

    2016.4 - 2016.9   First semester

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2016  岡山大学理学部臨海実験所　国際協力教員  Classification:Part-time faculty  Domestic/International Classification:Japan 

Other educational activity and Special note

  • 2017  Special Affairs 

    　詳細を見る

    I am in charge of the classes regarding the ecology, evolutionary biology iin IUPE general education courses. Student can widely learn the mechanism of biodiversity from the scopes of ecology, evolutionary biology, and environmental science.

Travel Abroad

  • 2024.9

    Staying countory name 1：Australia   Staying institution name 1：CSIRO (オーストラリア連邦科学産業研究機構)