Faculty Profiles - TSE KA FAI WILLIAM

Information

写真a

TSE KA FAI WILLIAM

Organization

Faculty of Agriculture Attached Promotive Center for International Education and Research of Agriculture Associate Professor
Faculty of Agriculture Attached Promotive Center for International Education and Research of Agriculture（Joint Appointment）
School of Agriculture Department of Bioresource and Bioenvironment（Joint Appointment）
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioresource Sciences（Joint Appointment）

Contact information

Tel

0926427046

Profile

Research: We have four major research themes: 1) Developmental functions of deubiquitylating enzyme: Deconjugation of ubiquitin and/or ubiquitin-like modified protein substrates is essential to modulate protein-protein interactions and, thus, signaling processes in cells. Although deubiquitylating (deubiquitinating) enzymes (DUBs) play a key role in this process, however, their function and regulation remain insufficiently understood. Our group performed the first genome-wide DUBs loss-of-function analysis in zebrafish, and we are now undergoing different experiments on selected DUBs to unfold their regulatory mechanisms and specific developmental functions. In 2013, we have identified that zebrafish transforming growth factor-β-stimulated clone 22 domain 3 (Tsc22d3) could function with two DUBs via the bone morphogenetic protein (bmp) pathway (Tse et al., 2013a). We are now working on the biochemical mechanism of the selected DUBs. 2) Disease model and mechanism: Zebrafish have been widely used in developmental biology, their well-established genome database and transparent embryos shaped them as an excellent developmental model. Recently, they are recruited as a new disease model. The zebrafish genome project identified that over 70% human disease causing genes can be found in the zebrafish genome. We own several organ-specific GFP-lines and mutants for different disease-based studies. Our group has a special interest on the mechanism of cleft lip and/or palate (CLP). CLP is one of the most common birth defects in the world, with an average frequency of 1/700. CLP besides affecting the appearance also causes significant morbidity in form and function. We selected several potential human CLP causing genes to study their functional roles in the facial development, which aim to understand the disease mechanism and thus identify small molecules to treat the disease before birth. Recently, we have identified the pathogenesis of the Type 3 Treacher Collins Syndrome by using a zebrafish model (Lau et al. 2016). 3) Osmoregulation: The capability of animal cells to maintain a constant cell volume is a prerequisite for cellular life. When eukaryotic cells are exposed to extracellular osmotic stress, they undergo rapid regulatory processes to maintain their cellular homeostatic status. The mechanism is particularly important in gill epithelia in fishes. Recently, our group applied the next-generation sequencing (NGS) and proteomics technologies to report the first eel gill specific transcriptome data and osmo-responsive proteins in eel gill (Tse et al. 2013b; Tse et al. 2014; Lai et al. 2015). Furthermore, our group use different fish models (eel, medaka, and zebrafish) to understand the molecular issues in the osmoregulation process (Chow et al. 2013; Lai et al. 2013; Tse et al. 2013c). 4) Developmental toxicity: Our group recently starts to apply developmental biology to environmental toxicology studies. Effects of toxicants on embryogenesis can be easily being tested in zebrafish embryos in a large scale. We have found that the exposure of environmental pollutant bisphenol A (BPA) and Triclosan could influence zebrafish embryos’ early development (Tse et al. 2013d) or lipid metabolism (Ho et al. 2016), respectively. Our group is now testing some other pollutants on their potential hazards on embryonic development. Education: I have teaching duties in the English-taught International undergraduate program, and am involved in the "Global Human Resource Development Project" (Hong Kong region).

External link

Research Areas

Natural Science / Biogeosciences

Degree

Ph.D; Hong Kong Baptist University (Hong Kong S.A.R.)

Research History

Kyushu University

2016.4 - Present

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Hong Kong Baptist University, Hong Kong 2012 – 2016 Research Assistant Professor, Department of Biology Beijing Normal University-Hong Kong Baptist University, United International College, Zhuhai, China 2015 Adjunct Assistant Professor , Environmental Science Massachusetts General Hospital, Harvard Medical School, USA 2011 – 2012 Research Fellow, Center for Regenerative Medicine Atmosphere and Ocean Research Institute, the University of Tokyo, Japan 2009 – 2011 JSPS Research Fellow/ Research Associate, Laboratory of Physiology Institute of Molecular and Cell Biology, A*STAR, Singapore 2007 – 2009 Research Fellow, Laboratory of Developmental Signalling and Patterning

Research Interests・Research Keywords

Research theme：Fish Osmoregulation

Keyword：Fish Osmoregulation

Research period： 2024
Research theme：Disease model and mechanism

Keyword：Disease model and mechanism

Research period： 2024
Research theme：Developmental Toxicology

Keyword：Developmental Toxicology

Research period： 2024
Research theme：Deubiquitinase

Keyword：Deubiquitinase

Research period： 2024
Research theme：disease pathogenesis

Keyword：zebrafish; disease model; disease mechanism

Research period： 2013.9
Research theme：developmental toxicology

Keyword：zebrafish; environmental pollutants

Research period： 2013.9
Research theme：Rare disease model; Environmental toxicant screening; Developmental Toxicology; Integrated omics

Keyword：Zebrafish; Disease model; Rare diseases; Craniofacial Developmental Biology; Signaling pathways; Experimental pathology; Environmental Sciences; Pollutant; Developmental toxicology; PFAS; Fish osmoregulation; Osmotic stress; Gill; Gut; Medaka

Research period： 2006.9 - 2034.2
Research theme：osmoregulation

Keyword：fish; gill; cellular volume; ion transporters; cytoskeleton

Research period： 2006.9

Awards

JSPS Postdoctoral Fellowship

2009.9 The Japan Society for the Promotion of Science (JSPS)
APDBN Travel Award

2009.5 The Asia-Pacific Developmental Biology Network (APDBN)
Student Travel Award

2006.1 7th International Congress on the Biology of Fish
Postgraduate studentship

2004.9 Hong Kong Baptist University

Papers

p53 inhibitor or antioxidants reduce the severity of ethmoid plate deformities in zebrafish Type 3 Treacher Collins syndrome model Reviewed International journal

Zulvikar Syambani Ulhaq, May-Su You, Yun-Jin Jiang, William Ka Fai Tse

International Journal of Biological Macromolecules 266 131216 2024.5

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DOI： DOI: 10.1016/j.ijbiomac.2024.131216
p53 inhibitor or antioxidants reduce the severity of ethmoid plate deformities in zebrafish Type 3 Treacher Collins syndrome model Reviewed International journal

Zulvikar Syambani Ulhaq, May-Su You, Yun-Jin Jiang, William Ka Fai Tse

International Journal of Biological Macromolecules 266 131216 2024.5 （ ISSN:01418130 ）

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DOI： 10.1016/j.ijbiomac.2024.131216

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Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation Invited Reviewed International journal

Zulvikar Syambani Ulhaq, Guido Barbieri Bittencourt, Gita Vita Soraya, Lola Ayu Istifiani, Syafrizal Aji Pamungkas, Yukiko Ogino, Dian Kesumapramudya Nurputra, William Ka Fai Tse

Molecular Aspects of Medicine 96 101238 2024.4

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DOI： DOI: 10.1016/j.mam.2023.101238
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation Invited Reviewed International journal

Zulvikar Syambani Ulhaq, Guido Barbieri Bittencourt, Gita Vita Soraya, Lola Ayu Istifiani, Syafrizal Aji Pamungkas, Yukiko Ogino, Dian Kesumapramudya Nurputra, William Ka Fai Tse

Molecular Aspects of Medicine 96 101238 2024.4 （ ISSN:00982997 ）

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DOI： 10.1016/j.mam.2023.101238

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Dysregulation of Spliceosomes Complex Induces Retinitis Pigmentosa–Like Characteristics in sf3b4-Depleted Zebrafish Reviewed International journal

193 ( 9 ) 1223 - 1233 2023.9

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The SF3B4 gene encodes a highly conserved protein that plays a critical role in mRNA splicing. Mutations in this gene are known to cause Nager syndrome, a rare craniofacial disorder. Although SF3B4 expression is detected in the optic vesicle before it is detected in the limb and somite, the role of SF3B4 in the eye is not well understood. This study investigated the function of sf3b4 in the retina by performing transcriptome profiles, immunostaining, and behavioral analysis of sf3b4−/− mutant zebrafish. Results from this study suggest that dysregulation of the spliceosome complex affects not only craniofacial development but also retinogenesis. Zebrafish lacking functional sf3b4 displayed characteristics similar to retinitis pigmentosa (RP), marked by severe retinal pigment epithelium defects and rod degeneration. Pathway analysis revealed altered retinol metabolism and retinoic acid signaling in the sf3b4−/− mutants. Supplementation of retinoic acid rescued key cellular phenotypes observed in the sf3b4−/− mutants, offering potential therapeutic strategies for RP in the future. In conclusion, this study sheds light on the previously unknown role of SF3B4 in retinogenesis and provides insights into the underlying mechanisms of RP.

DOI： DOI: 10.1016/j.ajpath.2023.05.008
Dysregulation of Spliceosomes Complex Induces Retinitis Pigmentosa–Like Characteristics in sf3b4-Depleted Zebrafish Reviewed International journal

Zulvikar Syambani Ulhaq, Keigo Okamoto, Yukiko Ogino, William Ka Fai Tse

American Journal Of Pathology 193 ( 9 ) 1223 - 1233 2023.9 （ ISSN:00029440 ）

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DOI： 10.1016/j.ajpath.2023.05.008

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Perfluorohexanesulfonic acid (PFHxS) induces oxidative stress and causes developmental toxicities in zebrafish embryos Reviewed International journal

Zulvikar Syambani Ulhaq; William Ka Fai Tse

Journal of Hazardous Materials 457 131722 2023.5

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DOI： DOI: 10.1016/j.jhazmat.2023.131722
Perfluorohexanesulfonic acid (PFHxS) induces oxidative stress and causes developmental toxicities in zebrafish embryos Reviewed International journal

Zulvikar Syambani Ulhaq; William Ka Fai Tse

Journal of Hazardous Materials 457 131722 2023.5 （ ISSN:03043894 ）

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DOI： 10.1016/j.jhazmat.2023.131722

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Integrated Omics Approaches Revealed the Osmotic Stress-Responsive Genes and Microbiota in Gill of Marine Medaka Reviewed International journal

Lai, Keng Po; Zhu, Peng; Boncan, Delbert Almerick T.; Yang, Lu; Leung, Cherry Chi Tim; Ho, Jeff Cheuk Hin; Lin, Xiao; Chan, Ting Fung; Kong, Richard Yuen Chong; Tse, William Ka Fai

MSYSTEMS 7 ( 2 ) 2022.4

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DOI： 10.1128/msystems.00047-22

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The use of glutathione to reduce oxidative stress status and its potential for modifying the extracellular matrix organization in cleft lip Reviewed International journal

Li, Rong; Huang, Chen; Ho, Jeff Cheuk Hin; Leung, Cherry Chi Tim; Kong, Richard Yuen Chong; Li, Yu; Liang, Xiao; Lai, Keng Po;@ Tse, William Ka Fai

FREE RADICAL BIOLOGY AND MEDICINE 164 130 - 138 2021.2

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DOI： 10.1016/j.freeradbiomed.2020.12.455
Osmotic stress induces gut microbiota community shift in fish Reviewed International journal

Lai, Keng Po; Lin, Xiao; Tam, Nathan; Ho, Jeff Cheuk Hin; Wong, Marty Kwok-Shing; Gu, Jie; Chan, Ting Fung; Tse, William Ka Fai

ENVIRONMENTAL MICROBIOLOGY 22 ( 9 ) 3784 - 3802 2020.9

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DOI： 10.1111/1462-2920.15150
Pathogenesis of POLR1C-dependent Type 3 Treacher Collins Syndrome revealed by a zebrafish model Reviewed

Marco Chi Chung Lau, Ernest Man Lok Kwong, Keng Po Lai, Jing Woei Li, Jeff Cheuk Hin Ho, Ting Fung Chan, Chris Kong Chu Wong, Yun Jin Jiang, Ka Fai William Tse

Biochimica et Biophysica Acta - Molecular Basis of Disease 1862 ( 6 ) 1147 - 1158 2016.6

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DOI： 10.1016/j.bbadis.2016.03.005
Roles and occurrences of microbiota in the osmoregulatory organs, gills and gut, in marine medaka upon hypotonic stress

Lai K.P., Boncan D.A.T., Qin X., Chan T.F., Tse W.K.F.

Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics 52 2024.12 （ ISSN:1744117X ）

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Gills and gut are the two primary osmoregulatory organs in fish. Recently, studies have expanded beyond the osmoregulatory mechanisms of these organs to explore the microbiota communities inhabiting them. It is now known that microbial communities in both organs shift in response to osmotic stress. However, there are limited studies identifying the major contributors and co-occurrence among these microbiota in both organs under seawater and freshwater transfer conditions. The current data mining report performed a bioinformatics analysis on two previous published datasets from our group, aiming to provide insights into host-bacteria relationships under osmotic stress. We divided the samples into four groups: control seawater gills (LSW); control seawater gut (TSW); freshwater transfer gills (LFW); and freshwater transfer gut (TFW). Our results showed that LSW had higher diversities, richness, and evenness compared to TSW. However, both the LFW and LSW did not show any significant differences after the freshwater transfer experiment. We further applied co-occurrence network analysis and, for the first time, reported on the interactions of taxa shaping the community structure in these two organs. Moreover, we identified enriched ectoine biosynthesis in seawater samples, suggesting its potential role in seawater environments. Increased mRNA expression levels of Na+/K+-atpase, and cftr, were observed in gills after 6 h of ectoine treatment. These findings provide a foundation for future studies on host-bacteria interactions under osmotic stress.

DOI： 10.1016/j.cbd.2024.101285

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Size-dependent deleterious effects of nano- and microplastics on sperm motility

Lin Z., Li Z., Ji S., Lo H.S., Billah B., Sharmin A., Han X., Lui W.y., Tse W.K.F., Fang J.K.H., Zhang C., Shang X., Lai K.P., Li L.

Toxicology 506 2024.8 （ ISSN:0300483X ）

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Introduction: Growing concerns regarding the reproductive toxicity associated with daily life exposure to micro-/nano-plastics (abbreviated as MNPs) have become increasingly prevalent. In reality, MNPs exposure involves a heterogeneous mixture of MNPs of different sizes rather than a single size. Methods: In this study, an oral exposure mouse model was used to evaluate the effects of MNPs of four size ranges: 25–30 nm, 1–5 µm, 20–27 µm, and 125–150 µm. Adult male C57BL/6 J mice were administered environmentally relevant concentrations of 0.1 mg MNPs/day for 21 days. After that, open field test and computer assisted sperm assessment (CASA) were conducted. Immunohistochemical analyses of organ and cell type localization of MNPs were evaluated. Testicular transcriptome analysis was carried out to understand the molecular mechanisms. Results: Our result showed that MNPs of different size ranges all impaired sperm motility, with a decrease in progressive sperm motility, linearity and straight-line velocity of sperm movement. Alterations did not manifest in animal locomotion, body weight, or sperm count. Noteworthy effects were most pronounced in the smaller MNPs size ranges (25–30 nm and 1–5 µm). Linear regression analysis substantiated a negative correlation between the size of MNPs and sperm curvilinear activity. Immunohistochemical analysis unveiled the intrusions of 1–5 µm MNPs, but not 20–27 µm and 125–150 µm MNPs, into Leydig cells and testicular macrophages. Further testicular transcriptomic analysis revealed perturbations in pathways related to spermatogenesis, oxidative stress, and inflammation. Particularly within the 1–5 µm MNPs group, a heightened perturbation in pathways linked to spermatogenesis and oxidative stress was observed. Conclusions: Our data support the size-dependent impairment of MNPs on sperm functionality, underscoring the pressing need for apprehensions about and interventions against the escalation of environmental micro-/nano-plastics contamination. This urgency is especially pertinent to small-sized MNPs.

DOI： 10.1016/j.tox.2024.153834

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Microplastics from face mask impairs sperm motility

Lin Z., Li Z., Ji S., Lo H.S., Billah B., Sharmin A., Lui W.y., Tse W.K.F., Fang J.K.H., Lai K.P., Li L.

Marine Pollution Bulletin 203 2024.6 （ ISSN:0025326X ）

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The COVID-19 pandemic has resulted in unprecedented plastic pollution from single-used personal protective equipment (PPE), especially face masks, in coastal and marine environments. The secondary pollutants, microplastics from face masks (mask MP), rise concern about their detrimental effects on marine organisms, terrestrial organisms and even human. Using a mouse model, oral exposure to mask MP at two doses, 0.1 and 1 mg MP/day for 21 days, caused no change in animal locomotion, total weight, or sperm counts, but caused damage to sperm motility with increased curvilinear velocity (VCL). The high-dose mask MP exposure caused a significant decrease in linearity (LIN) of sperm motility. Further testicular transcriptomic analysis revealed perturbed pathways related to spermatogenesis, oxidative stress, inflammation, metabolism and energy production. Collectively, our findings substantiate that microplastics from face masks yield adverse effects on mammalian reproductive capacity, highlighting the need for improved plastic waste management and development of environmentally friendly materials.

DOI： 10.1016/j.marpolbul.2024.116422

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Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish Reviewed International journal

Zulvikar Syambani Ulhaq, William Ka Fai Tse

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 ( 4 ) 167128 2024.4

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DOI： DOI: 10.1016/j.bbadis.2024.167128
Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish Reviewed International journal

Zulvikar Syambani Ulhaq, William Ka Fai Tse

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 ( 4 ) 167128 2024.4 （ ISSN:09254439 ）

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DOI： 10.1016/j.bbadis.2024.167128

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Transcriptome alterations in sf3b4-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model Reviewed International journal

Zulvikar Syambani Ulhaq, Yukiko Ogino, William Ka Fai Tse

Experimental Eye Research 240 109819 2024.3

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DOI： DOI: 10.1016/j.exer.2024.109819
Transcriptome alterations in sf3b4-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model Reviewed International journal

Zulvikar Syambani Ulhaq, Yukiko Ogino, William Ka Fai Tse

Experimental Eye Research 240 109819 2024.3 （ ISSN:00144835 ）

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DOI： 10.1016/j.exer.2024.109819

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PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease Invited Reviewed International journal

Zulvikar Syambani Ulhaq, William Ka Fai Tse

Genes 15 ( 1 ) 93 2024.1

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DOI： DOI: 10.3390/genes15010093
PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease Invited Reviewed International journal

Zulvikar Syambani Ulhaq, William Ka Fai Tse

Genes 15 ( 1 ) 93 2024.1

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DOI： 10.3390/genes15010093

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Microplastic exposure disturbs sleep structure, reduces lifespan, and decreases ovary size in Drosophila melanogaster

Yan W., Li Z.J., Lin Z.Y., Ji S.Q., Tse W.K.F., Meng Z.Q., Liu C., Li L.

Zoological Research 45 ( 4 ) 805 - 820 2024

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The organ-specific toxicity resulting from microplastic (MP) exposure has been extensively explored, particularly concerning the gut, liver, testis, and lung. However, under natural conditions, these effects are not restricted to specific organs or tissues. Investigating whether MP exposure presents a systemic threat to an entire organism, impacting factors such as lifespan, sleep, and fecundity, is essential. In this study, we investigated the effects of dietary exposure to two different doses of MPs (1–5 μm) using the terrestrial model organism Drosophila melanogaster. Results indicated that the particles caused gut damage and remained within the digestive system. Continuous MP exposure significantly shortened the lifespan of adult flies. Even short-term exposure disrupted sleep patterns, increasing the length of daytime sleep episodes. Additionally, one week of MP exposure reduced ovary size, with a trend towards decreased egg-laying in mated females. Although MPs did not penetrate the brain or ovaries, transcriptome analysis revealed altered gene expression in these tissues. In the ovary, Gene Ontology (GO) analysis indicated genotoxic effects impacting inflammation, circadian regulation, and metabolic processes, with significant impacts on extracellular structure-related pathways. In the brain, GO analysis identified changes in pathways associated with proteolysis and carbohydrate metabolism. Overall, this study provides compelling evidence of the systemic negative effects of MP exposure, highlighting the urgent need to address and mitigate environmental MP pollution.

DOI： 10.24272/j.issn.2095-8137.2024.038

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Insights from metabolomics and transcriptomics studies on Perfluorohexanesulfonic acid (PFHxS) exposed zebrafish embryos Reviewed International journal

Zulvikar Syambani Ulhaq, Delbert Almerick T Boncan, Ting-Fung Chan, William Ka Fai Tse

Science of The Total Environment 904 ( 15 ) 166833 2023.12

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DOI： DOI: 10.1016/j.scitotenv.2023.166833
Insights from metabolomics and transcriptomics studies on Perfluorohexanesulfonic acid (PFHxS) exposed zebrafish embryos Reviewed International journal

Zulvikar Syambani Ulhaq, Delbert Almerick T Boncan, Ting-Fung Chan, William Ka Fai Tse

Science of The Total Environment 904 ( 15 ) 166833 2023.12 （ ISSN:00489697 ）

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DOI： 10.1016/j.scitotenv.2023.166833

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Editorial: Novel small molecules in targeted cancer therapy Invited Reviewed International journal

Rong Li, Xian-Li Ma, Chao Gou, William Ka Fai Tse

Frontiers in Pharmacology 14 1272523 2023.8

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DOI： DOI: 10.3389/fphar.2023.1272523
Editorial: Novel small molecules in targeted cancer therapy Invited Reviewed International journal

Rong Li, Xian-Li Ma, Chao Gou, William Ka Fai Tse

Frontiers in Pharmacology 14 1272523 2023.8

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DOI： 10.3389/fphar.2023.1272523

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Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model Reviewed International journal

Ulhaq, Zulvikar Syambani; Ogino, Yukiko; Tse, William Ka Fai

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 664 100 - 107 2023.7 （ ISSN:0006291X ）

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DOI： 10.1016/j.bbrc.2023.04.096

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Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer Reviewed International journal

Huanhuan Zhou1, Lu Yang, Xiao Lin, Ting Fung Chan, Nikki Pui-Yue Lee, William Ka Fai Tse, Xing Zhang, Rong Li, Keng Po Lai

AGING (Albany NY) 15 ( 10 ) 4304 - 4318 2023.5

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DOI： https://doi.org/10.18632/aging.204733
Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer Reviewed International journal

Huanhuan Zhou1, Lu Yang, Xiao Lin, Ting Fung Chan, Nikki Pui-Yue Lee, William Ka Fai Tse, Xing Zhang, Rong Li, Keng Po Lai

AGING (Albany NY) 15 ( 10 ) 4304 - 4318 2023.5 （ ISSN:19454589 ）

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DOI： 10.18632/aging.204733

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FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18 Reviewed International journal

Ulhaq, Zulvikar Syambani; Ogino, Yukiko; Tse, William Ka Fai

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 652 76 - 83 2023.4 （ ISSN:0006291X ）

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DOI： 10.1016/j.bbrc.2023.02.046

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Editorial: New drugs for treating COVID-19 cancer patients Reviewed International journal

Lai, Keng Po; Li, Rong; Wu, Ka; Tse, William Ka Fai

FRONTIERS IN ENDOCRINOLOGY 14 2023.3

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DOI： 10.3389/fendo.2023.1151942

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A systematic review on Treacher Collins syndrome: Correlation between molecular genetic findings and clinical severity Reviewed International journal

Zulvikar Syambani Ulhaq, Dian Kesumapramudya Nurputra, Gita Vita Soraya, Siti Kurniawati, Lola Ayu Istifiani, Syafrizal Aji Pamungkas, William Ka Fai Tse

CLINICAL GENETICS 103 ( 2 ) 146 - 155 2023.2 （ ISSN:00099163 ）

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DOI： 10.1111/cge.14243

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A Brief Analysis on Clinical Severity of Mandibulofacial Dysostosis Guion-Almeida Type Reviewed International journal

Ulhaq, Zulvikar Syambani; Soraya, Gita Vita; Istifiani, Lola Ayu; Pamungkas, Syafrizal Aji; Arisanti, Ditya; Dini, Badariyatud; Astari, Lina Fitria; Hasan, Yuliono Trika Nur; Ayudianti, Prida; Kusuma, Muhammad A'raaf Sirojan; Shodry, Syifaus; Herawangsa, Sarah; Nurputra, Dian Kesumapramudya; Idaiani, Sri; Tse, William Ka Fai

CLEFT PALATE-CRANIOFACIAL JOURNAL 61 ( 4 ) 688 - 696 2022.11 （ ISSN:10556656 ）

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DOI： 10.1177/10556656221136177

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Micro-CT analysis reveals the changes in bone mineral density in zebrafish craniofacial skeleton with age Reviewed International journal

Liao, Wei-Neng; You, May-Su; Ulhaq, Zulvikar Syambani; Li, Jui-Ping; Jiang, Yun-Jin; Chen, Jen-Kun; Tse, William Ka Fai

JOURNAL OF ANATOMY 242 ( 3 ) 544 - 551 2022.10 （ ISSN:00218782 ）

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DOI： 10.1111/joa.13780

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Osmotic Gradient Is a Factor That Influences the Gill Microbiota Communities in Oryzias melastigma Reviewed International journal

Lai, Keng Po; Boncan, Delbert Almerick T.; Yang, Lu; Leung, Cherry Chi Tim; Ho, Jeff Cheuk Hin; Lin, Xiao; Chan, Ting Fung; Kong, Richard Yuen Chong; Tse, William Ka Fai

BIOLOGY-BASEL 11 ( 10 ) 2022.10

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DOI： 10.3390/biology11101528

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Transcriptomic Analysis in Marine Medaka Gill Reveals That the Hypo-Osmotic Stress Could Alter the Immune Response via the IL17 Signaling Pathway Reviewed International journal

Li, Rong; Liu, Jiaqi; Leung, Chi Tim; Lin, Xiao; Chan, Ting Fung; Tse, William Ka Fai; Lai, Keng Po

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 ( 20 ) 2022.10 （ ISSN:16616596 ）

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DOI： 10.3390/ijms232012417

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Editorial: Homeostasis and physiological regulation in the aquatic animal during osmotic stress Invited Reviewed International journal

Jin, Xingkun; Wang, Xiaodan; Tse, William Ka Fai; Shi, Yan

FRONTIERS IN PHYSIOLOGY 13 2022.8

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DOI： 10.3389/fphys.2022.977185

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Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis Reviewed International journal

Liu, Jiaqi; Leung, Chi Tim; Liang, Luyun; Wang, Yuqin; Chen, Jian; Lai, Keng Po; Tse, William Ka Fai

CANCERS 14 ( 14 ) 2022.7

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DOI： 10.3390/cancers14143547

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SF3B4 Frameshift Variants Represented a More Severe Clinical Manifestation in Nager Syndrome Reviewed International journal

Ulhaq, Zulvikar Syambani; Soraya, Gita Vita; Istifiani, Lola Ayu; Pamungkas, Syafrizal Aji; Tse, William Ka Fai

CLEFT PALATE-CRANIOFACIAL JOURNAL 60 ( 8 ) 1041 - 1047 2022.3 （ ISSN:10556656 ）

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DOI： 10.1177/10556656221089156

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2,4-dichlorophenol exposure induces lipid accumulation and reactive oxygen species formation in zebrafish embryos Invited Reviewed International journal

Tsukazawa, Kazumi Sunny; Li, Lei; Tse, William Ka Fai

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 230 2022.1 （ ISSN:01476513 ）

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DOI： 10.1016/j.ecoenv.2021.113133

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miRNA-mRNA Integrative Analysis Reveals the Roles of miRNAs in Hypoxia-Altered Embryonic Development- and Sex Determination-Related Genes of Medaka Fish Reviewed International journal

Lai, Keng Po; Tam, Nathan Yi Kan; Chen, Yuelong; Leung, Chi Tim; Lin, Xiao; Tsang, Chau Fong; Kwok, Yin Cheung; Tse, William Ka Fai; Cheng, Shuk Han; Chan, Ting Fung; Kong, Richard Yuen Chong

FRONTIERS IN MARINE SCIENCE 8 2022.1

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DOI： 10.3389/fmars.2021.736362

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A brief analysis of proteomic profile changes during zebrafish regeneration

Ulhaq Z.S., Tse W.K.F.

Biomolecules 12 ( 1 ) 2022.1

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Publisher：Biomolecules

Unlike mammals, zebrafish are capable to regenerate many of their organs, however, the response of tissue damage varies across tissues. Understanding the molecular mechanism behind the robust regenerative capacity in a model organism may help to identify and develop novel treatment strategies for mammals (including humans). Hence, we systematically analyzed the current literature on the proteome profile collected from different regenerated zebrafish tissues. Our analyses underlining that several proteins and protein families responsible as a component of cytoskeleton and structure, protein synthesis and degradation, cell cycle control, and energy metabolism were frequently identified. Moreover, target proteins responsible for the initiation of the regeneration process, such as inflammation and immune response were less frequently detected. This highlights the limitation of previous proteomic analysis and suggested a more sensitive modern proteomics analysis is needed to unfold the mechanism. This brief report provides a list of target proteins with predicted functions that could be useful for further biological studies.

DOI： 10.3390/biom12010035

Scopus
Changes of the intestinal microbiota along the gut of Japanese Eel (Anguilla japonica) Reviewed International journal

Zhu, P.; Wong, M. K. -S; Lin, X.; Chan, T. F.; Wong, C. K. C.; Lai, K. P.; Tse, W. K. F.

LETTERS IN APPLIED MICROBIOLOGY 73 ( 4 ) 529 - 541 2021.10

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DOI： 10.1111/lam.13539
Zebrafish as the toxicant screening model: Transgenic and omics approaches Reviewed International journal

Lai, Keng Po; Gong, Zhiyuan; Tse, William Ka Fai

AQUATIC TOXICOLOGY 234 2021.5

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DOI： 10.1016/j.aquatox.2021.105813
Proteomic Response of the Brain to Hypoxic Stress in Marine Medaka Fish (Oryzias melastigma) Reviewed International journal

Lai, Keng Po; Tam, Nathan; Wang, Simon Yuan; Tse, William Ka Fai; Lin, Xiao; Chan, Ting Fung; Tong, Yin; Zhang, Jianwen; Au, Doris Wai Ting; Sun, Rudolf Shiu; Kong, Richard Yuen Chong

FRONTIERS IN MARINE SCIENCE 8 2021.5

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DOI： 10.3389/fmars.2021.618489
Bisphenol A and its analogues in sedimentary microplastics of Hong Kong Reviewed International journal

Lo, Hoi Shing; Po, Beverly Hoi Ki; Li, Laam; Wong, Aman Yi Man; Kong, Richard Yuen Chong; Li, Lei; Tse, William Ka Fai; Wong, Chris Kong Chu; Cheung, Siu Gin; Lai, Keng Po

MARINE POLLUTION BULLETIN 164 2021.3

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DOI： 10.1016/j.marpolbul.2021.112090
Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19 Reviewed International journal

Li, Rong; Wu, Ka; Li, Yu; Liang, Xiao; Tse, William Ka Fai; Yang, Lu; Lai, Keng Po

AGING-US 12 ( 15 ) 15784 - 15796 2020.8

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Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism Reviewed International journal

Dahlem, Charlotte; Siow, Wei Xiong; Lopatniuk, Maria; Tse, William K. F.; Kessler, Sonja M.; Kirsch, Susanne H.; Hoppstaedter, Jessica; Vollmar, Angelika M.; Mueller, Rolf; Luzhetskyy, Andriy; Bartel, Karin; Kiemer, Alexandra K

CANCERS 12 ( 5 ) 2020.5

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DOI： 10.3390/cancers12051288
Role of deubiquitinases in human cancers Potential targeted therapy Invited Reviewed International journal

Keng Po Lai, Jian Chen, William Ka Fai Tse

International journal of molecular sciences 21 ( 7 ) 2020.4

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DOI： 10.3390/ijms21072548
Metabolomic analysis reveals metabolic alterations of human peripheral blood lymphocytes by perfluorooctanoic acid Reviewed

Rong Li, Chao Guo, Ka Fai William Tse, Min Su, Xiaoxi Zhang, Keng Po Lai

Chemosphere 239 2020.1

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DOI： 10.1016/j.chemosphere.2019.124810
The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage Reviewed International journal

FASEB Journal 2020.1

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DOI： 10.1096/fj.201902557RRR
The Glucocorticoid-Induced Leucine Zipper (GILZ) mediates statin-induced muscle damage Invited Reviewed International journal

Perez, J. V. Valbuena; Hoppstaedter, J.; Tse, W. K. F.; Bruscoli, S.; Flamini, S.; Andreas, A.; Herrmann, J.; Mueller, R.; Riccardi, C.; Kiemer, A. K.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 392 S7 - S8 2019.2

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Restoration of polr1c in Early Embryogenesis Rescues the Type 3 Treacher Collins Syndrome Facial Malformation Phenotype in Zebrafish Reviewed

Ernest Man Lok Kwong, Jeff Cheuk Hin Ho, Marco Chi Chung Lau, May Su You, Yun Jin Jiang, Ka Fai William Tse

American Journal of Pathology 188 ( 2 ) 336 - 342 2018.2

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DOI： 10.1016/j.ajpath.2017.10.004
Identification of immune-related genes in gill cells of Japanese eels (Anguilla japonica) in adaptation to water salinity changes Reviewed

Jie Gu, Shuya Dai, Haitao Liu, Quanquan Cao, Shaowu Yin, Keng Po Lai, Ka Fai William Tse, Chris Kong Chu Wong, Haifeng Shi

Fish and Shellfish Immunology 73 288 - 296 2018.2

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DOI： 10.1016/j.fsi.2017.12.026
Comparative transcriptomic characterization of a new mib mutant allele, mibⁿⁿ²⁰⁰², in zebrafish Reviewed

Keng Po Lai, Jing Woei Li, Chia Hao Hsu, May Su You, Ting Fung Chan, Ka Fai William Tse, Yun Jin Jiang

Gene 642 51 - 57 2018.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.gene.2017.11.016
Activation of Ca²⁺-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells Reviewed

Jie Gu, Shuya Dai, Yanmin Liu, Haitao Liu, Yao Zhang, Xingqi Ji, Feng Yu, Yang Zhou, Liang Chen, Ka Fai William Tse, Chris Kong Chu Wong, Binghai Chen, Haifeng Shi

Scientific Reports 8 ( 1 ) 2017.12

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DOI： 10.1038/s41598-018-19327-9
Deubiquitinase Usp18 prevents cellular apoptosis from oxidative stress in liver cells Reviewed

Keng Po Lai, Angela Hoi Yan Cheung, Ka Fai William Tse

Cell Biology International 41 ( 8 ) 914 - 921 2017.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/cbin.10799
Importance of deubiquitinases in zebrafish craniofacial development Reviewed

Ka Fai William Tse

Biochemical and Biophysical Research Communications 487 ( 4 ) 813 - 819 2017.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbrc.2017.04.132
Developmental toxicity of the common UV filter, benophenone-2, in zebrafish embryos Reviewed

Henry C.H. Fong, Jeff C.H. Ho, Angela H.Y. Cheung, K. P. Lai, Ka Fai William Tse

Chemosphere 164 413 - 420 2016.12

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DOI： 10.1016/j.chemosphere.2016.08.073
Treacher Collins syndrome New insights from animal models Reviewed

Ka Fai William Tse

International Journal of Biochemistry and Cell Biology 81 44 - 47 2016.12

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DOI： 10.1016/j.biocel.2016.10.016
Fatty liver disease induced by perfluorooctane sulfonate Novel insight from transcriptome analysis Reviewed

Ka Fai William Tse, Jing Woei Li, Anna Chung Kwan Tse, Ting Fung Chan, Jeff Cheuk Hin Ho, Rudolf Shiu Sun Wu, Chris Kong Chu Wong, Keng Po Lai

Chemosphere 159 166 - 177 2016.9

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DOI： 10.1016/j.chemosphere.2016.05.060
Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos Reviewed

Jeff C.H. Ho, C. D. Hsiao, K. Kawakami, Ka Fai William Tse

Aquatic Toxicology 173 29 - 35 2016.4

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DOI： 10.1016/j.aquatox.2016.01.001
Transcriptomic analysis reveals specific osmoregulatory adaptive responses in gill mitochondria-rich cells and pavement cells of the Japanese eel Reviewed

Keng Po Lai, Jing Woei Li, Je Gu, Ting Fung Chan, Ka Fai William Tse, Chris Kong Chu Wong

BMC Genomics 16 ( 1 ) 2015.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s12864-015-2271-0
Data for transcriptomic and iTRAQ proteomic analysis of Anguilla japonica gills in response to osmotic stress Reviewed

Ka Fai William Tse, Jin Sun, Huoming Zhang, Keng Po Lai, Jie Gu, Alice Yu Sheung Law, Bonnie Ho Yee Yeung, Sheung Ching Chow, Jian Wen Qiu, Chris Kong Chu Wong

Data in Brief 3 120 - 125 2015.6

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DOI： 10.1016/j.dib.2015.02.012
A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect Reviewed

Chia Hao Hsu, Ji Sheng Lin, Keng Po Lai, Jing Woei Li, Ting Fung Chan, May Su You, Ka Fai William Tse, Yun Jin Jiang

Scientific Reports 5 2015.6

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DOI： 10.1038/srep10673
Transcriptomic responses of corpuscle of Stannius gland of Japanese eels (Anguilla japonica) to Changes in Water Salinity Reviewed

Jie Gu, Jing Woei Li, Ka Fai William Tse, Ting Fung Chan, Keng Po Lai, Chris Kong Chu Wong

Scientific Reports 5 2015.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/srep09836
Tissue-specific transcriptome assemblies of the marine medaka Oryzias melastigma and comparative analysis with the freshwater medaka Oryzias latipes Reviewed

Keng P.o. Lai, Jing Woei Li, Simon Y.uan Wang, Jill M.an Ying Chiu, Anna Tse, Karen Lau, Si Lok, Doris W.ai Ting Au, Ka Fai William Tse, Chris K.ong Chu Wong, Ting Fung Chan, Richard Y.uen Chong Kong, Rudolf S.hiu Sun Wu

BMC Genomics 16 2015.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s12864-015-1325-7
ITRAQ-based quantitative proteomic analysis reveals acute hypo-osmotic responsive proteins in the gills of the Japanese eel (Anguilla japonica) Reviewed

Ka Fai William Tse, Jin Sun, Huoming Zhang, Keng Po Lai, Jie Gu, Jian Wen Qiu, Chris Kong Chu Wong

Journal of Proteomics 105 133 - 143 2014.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jprot.2014.01.025
The use of whole mount in situ hybridization screening to understand the developmental toxicology of environmental pollutants in zebrafish embryos

Ka Fai William Tse

Zebrafish: Topics in Reproduction, Toxicology and Development 215 - 224 2014.4

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The role of osmotic stress transcription factor 1 in fishes Reviewed

Ka Fai William Tse

Frontiers in Zoology 11 ( 1 ) 2014

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s12983-014-0086-5
Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis Reviewed

George Kamel, Tatiana Hoyos, Lucie Rochard, Max Dougherty, Yawei Kong, Ka Fai William Tse, Valeriy Shubinets, Michael Grimaldi, Eric C. Liao

Developmental Biology 381 ( 2 ) 423 - 433 2013.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.ydbio.2013.06.012
Transcriptomic and iTRAQ proteomic approaches reveal novel short-term hyperosmotic stress responsive proteins in the gill of the Japanese eel (Anguilla japonica) Reviewed

Ka Fai William Tse, Jin Sun, Huoming Zhang, Alice Yu Sheung Law, Bonnie Ho Yee Yeung, Sheung Ching Chow, Jian Wen Qiu, Chris Kong Chu Wong

Journal of Proteomics 89 81 - 94 2013.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jprot.2013.05.026
Zebrafish transforming growth factor-β-stimulated clone 22 domain 3 (TSC22D3) plays critical roles in Bmp-dependent dorsoventral patterning via two deubiquitylating enzymes Usp15 and Otud4 Reviewed

1830 ( 10 ) 4584 - 4593 2013.7

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Background Osmotic stress transcription factor 1/transforming growth factor-β-stimulated clone 22 domain 3 (Ostf1/Tsc22d3) is a transcription factor that plays an osmoregulatory role in euryhaline fishes. Its mRNA and protein levels are up-regulated under hyperosmotic stress. However, its osmoregulatory and developmental functions have not been studied in any stenohaline freshwater fishes. Zebrafish is an excellent model to perform such study to unfold the functional role of Tsc22d3. Methods We identified the zebrafish Tsc22d3 and performed knockdown studies using morpholino antisense oligonucleotide (MO). Results Zebrafish Tsc22d3 did not response to hypertonic stress and ts22d3 knockdown or overexpression by injecting MO or capped RNA did not change the transcriptional levels of any of the known ionocyte markers. To reveal the unknown function of zebrafish Tsc22d3, we performed several in situ molecular marker studies on tsc22d3 morphants and found that Tsc22d3 plays multi-functional roles in dorsoventral (DV) patterning, segmentation, and brain development. We then aimed to identify the mechanism of Tsc22d3 in the earliest stages of DV patterning. Our results demonstrated that tsc22d3 is a ventralizing gene that can stimulate the transcription of bone morphogenetic protein 4 (bmp4) and, thus, has a positive effect on the Bmp signaling pathway. Furthermore, we showed that Tsc22d3 interacts with deubiquitylating enzymes, ubiquitin-specific protease 15 (Usp15) and ovarian tumor domain containing protein 4 (Otud4). In addition, the interruption of Bmp4 signaling by double knockdown of usp15 and otud4 reduced the ventralized effects in tsc22d3-overexpressing embryos. Conclusions This is the first study to identify new developmental functions of Tsc22d3 in zebrafish. General significance Zebrafish tsc22d3 is a ventralizing gene and plays a role in early embryogenesis.

DOI： 10.1016/j.bbagen.2013.05.006
Dexamethasone (DEX) induces osmotic stress transcription factor 1 (Ostf1) through the Akt-GSK3β pathway in freshwater Japanese eel gill cell cultures Reviewed

2 ( 5 ) 487 - 491 2013.5

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Osmosensing and osmoregulatory processes undertaken in gills of euryhaline fish are coordinated by integrative actions of various signaling molecules/transcriptional factors. Considerable numbers of studies report the hyper- and hypoosmoregulatory functions of fish gills, by illustrating the process of gill cell remodeling and the modulation of the expression of ion channels/transporters. Comparatively mechanistic information relayed from signal integration to transcriptional regulation in mediating gill cell functions has not yet been elucidated. In this study we demonstrate the functional links from cortisol stimulation, to Akt activation, to the expression of the transcriptional factor, Ostf1. Using the synthetic glucocorticoid receptor agonist, dexamethasone (DEX), Ostf1 expression is found to be activated via glucocorticoid receptor (GR) and mediated by the Akt-GSK3β signaling pathway. Pharmacological experiments using kinase inhibitors reveal that the expression of Ostf1 is negatively regulated by Akt activation. The inhibition of PI3K or Akt activities, by the specific kinase inhibitors (wortmannin, LY294002 or SH6), stimulates Ostf1 expression, while a reduction of GSK3β activity by LiCl reduces Ostf1 expression. Collectively, our report for the first time indicates that DEX can induce Ostf1 via GR, with the involvement of the Akt-GSK3β signaling pathway in primary eel gill cell cultures. The data also suggest that Ostf1 may play different roles in gill cell survival during seawater acclimation.

DOI： 10.1242/bio.20134135
Early embryogenesis in zebrafish is affected by bisphenol A exposure Reviewed

Ka Fai William Tse, Bonnie H.Y. Yeung, H. T. Wan, Chris K.C. Wong

Biology Open 2 ( 5 ) 466 - 471 2013.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1242/bio.20134283
Osmotic stress transcription factor 1b (Ostf1b) promotes migration properties with the modulation of epithelial mesenchymal transition (EMT) phenotype in human embryonic kidney cell Reviewed

K. P. Lai, Alice Y.S. Law, Marco C.C. Lau, Y. Takei, Ka Fai William Tse, Chris K.C. Wong

International Journal of Biochemistry and Cell Biology 45 ( 8 ) 1921 - 1926 2013.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biocel.2013.05.023
Eel osmotic stress transcriptional factor 1 (Ostf1) is highly expressed in gill mitochondria-rich cells, where ERK phosphorylated Reviewed

Ka Fai William Tse, Sheung C. Chow, Chris K C Wong

Frontiers in Zoology 9 2012.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1742-9994-9-3
Functional screen of zebrafish deubiquitylating enzymes by morpholino knockdown and in situ hybridization

Ka Fai William Tse, Yun Jin Jiang

Functional Genomics Methods and Protocols 815 321 - 331 2012.1

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Language：English

DOI： 10.1007/978-1-61779-424-7_24
Modulation of gene transcriptional level of different ion transporters in eel gill mitochondria-rich cells upon osmotic stress

Ka Fai William Tse, Chris Kong Chu Wong

Eels: Physiology, Habitat and Conservation 133 - 148 2012

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Medaka osmotic stress transcription factor 1b (Ostf1b/TSC22D3-2) triggers hyperosmotic responses of different ion transporters in medaka gill and human embryonic kidney cells via the JNK signalling pathway Reviewed

Ka Fai William Tse, K. P. Lai, Y. Takei

International Journal of Biochemistry and Cell Biology 43 ( 12 ) 1764 - 1775 2011.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.biocel.2011.08.013
Modulation of ion transporter expression in gill mitochondrion-rich cells of eels acclimated to low-Na+ or-Cl- freshwater Reviewed

Ka Fai William Tse, S. C. Chow, K. P. Lai, D. W T Au, Chris K C Wong

Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 315 A ( 7 ) 385 - 393 2011.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/jez.681
Nbce1 and H+-atpase mRNA expression are stimulated in the mitochondria-rich cells of freshwater-acclimating Japanese eels (Anguilla japonica) Reviewed

Ka Fai William Tse, Chris Kong Chu Wong

Canadian Journal of Zoology 89 ( 4 ) 348 - 355 2011.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1139/z11-009
The deubiquitylating enzyme, Cops6, regulates different developmental processes during early zebrafish embryogenesis Reviewed

Ka Fai William Tse, May Su You, Steven Hao Kee Ho, Yun Jin Jiang

International Journal of Developmental Biology 55 ( 1 ) 19 - 24 2011

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1387/ijdb.103089wt
Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development Reviewed

Ka Fai William Tse, Birgit Eisenhaber, Steven H K Ho, Qimei Ng, Frank Eisenhaber, Yun Jin Jiang

BMC Genomics 10 2009.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/1471-2164-10-637
The cloning of eel osmotic stress transcription factor and the regulation of its expression in primary gill cell culture Reviewed

Ka Fai William Tse, S. C. Chow, C. K C Wong

Journal of Experimental Biology 211 ( 12 ) 1964 - 1968 2008.6

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DOI： 10.1242/jeb.017368
Effect of osmotic shrinkage and hormones on the expression of Na +/H+ exchanger-1, Na+/K+/2C1 - cotransporter and Na+/K+-ATPase in gill pavement cells of freshwater adapted Japanese eel, Anguilla japonica Reviewed

Ka Fai William Tse, Doris W T Au, Chris K C Wong

Journal of Experimental Biology 210 ( 12 ) 2113 - 2120 2007.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1242/jeb.004101
Characterization of ion channel and transporter mRNA expressions in isolated gill chloride and pavement cells of seawater acclimating eels Reviewed

Ka Fai William Tse, Doris W T Au, Chris K C Wong

Biochemical and Biophysical Research Communications 346 ( 4 ) 1181 - 1190 2006.8

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DOI： 10.1016/j.bbrc.2006.06.028
Energy and redox states in the C6 glioma cells following acute exposure to Zn, Se⁺⁴, and Se⁺⁶ and the correlation with apoptosis Reviewed

M. S. Yang, Ka Fai William Tse, L. C. Yu, K. M. Li, N. K. Mak, R. C. Gupta

Toxicology Mechanisms and Methods 16 ( 1 ) 13 - 19 2006.1

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DOI： 10.1080/15376520500194692

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Books

Advances in Environmental Research

SK. TSUKAZAWA, KA FAI WILLIAM TSE（ Role： Joint author）

Nova Science Publishers, New York 2020.2

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Responsible for pages：In: Advances in Environmental Research, Justin A. Daniels (ed.). Nova Science Publishers, New York. 2020. Vol 70: 127-143. Language：English Book type：Scholarly book

The risk of zinc oxide nanoparticles in the aquatic environment.
Advances in medicine and biology

KA FAI WILLIAM TSE（ Role： Sole author）

Nova Science Publishers, New York 2019.1

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Responsible for pages：In: Advances in medicine and biology, Leon V. Berhardt (eds.), Nova Science Publishers, New York. 2019. 201-214. Language：English Book type：Scholarly book

The use of morpholino knockdown technology in zebrafish toxicology studies.
Zebrafish: Topics in Reproduction and Development

KA FAI WILLIAM TSE（ Role： Joint author）

Nova Science Publishers, New York 2014.6

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Responsible for pages：In: Zebrafish: Topics in Reproduction and Development, E. Carver, and CA. Lessman (eds.), Nova Science Publishers, New York. 215-224. Language：English Book type：Scholarly book

The use of whole mount in-situ hybridization screening to understand the developmental toxicology of environmental pollutants in zebrafish embryos.
Eel: Physiology, Habitat and Conservation

KA FAI WILLIAM TSE, CKC Wong（ Role： Joint author）

Nova Science Publishers, New York 2012.1

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Responsible for pages：In: Eel: Physiology, Habitat and Conservation, N. Sachilo, and M. Fujimoto (eds.), Nova Science Publishers, New York. 133-148. Language：English Book type：Scholarly book

Modulation of gene transcriptional level of different ion transporters in eel gill mitochondria-rich cells upon osmotic stress

Presentations

Zebrafish as a toxicant screening model Invited International conference

KA FAI WILLIAM TSE

Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, China 2022.11

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Event date： 2022.11

Language：English Presentation type：Oral presentation (general)

Country：China
The pathogenesis of Type 3 Treacher Collins Syndrome Invited

KA FAI WILLIAM TSE

Institute of Molecular and Cellular Regulation, Gunma University 2018.11

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Event date： 2022.11

Language：English Presentation type：Oral presentation (general)

Country：Japan
Zebrafish as a toxicant screening model Invited International conference

KA FAI WILLIAM TSE

Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, China 2022.11

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Event date： 2022.11

Language：English

Venue：Online Country：China

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The pathogenesis of Type 3 Treacher Collins Syndrome Invited

KA FAI WILLIAM TSE

Institute of Molecular and Cellular Regulation, Gunma University 2018.11

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Event date： 2022.11

Language：English

Venue：Institute of Molecular and Cellular Regulation, Gunma University Country：Japan

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Current trend in developmental toxicology and the application of omics International conference

KA FAI WILLIAM TSE

The 53rd Annual Meeting of the Japanese Society of Developmental Biologists (JSDB) 2020.5

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Event date： 2020.5

Language：English Presentation type：Symposium, workshop panel (public)

Country：Japan
Unfolding the disease mechanism of Type 3 Treacher Collins syndrome by zebrafish model International conference

KA FAI WILLIAM TSE

2019 International Zebrafish Conference 2019.8

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Event date： 2019.8

Language：English

Country：China
The developmental toxicity of metal nanoparticle in zebrafish International conference

KA FAI WILLIAM TSE

The 52nd Annual Meeting of the Japanese Society of Developmental Biologists (JSDB) 2019.5

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Event date： 2019.5

Language：English

Country：Japan
Oxidative stress in Type-3 Treacher Collins Syndrome zebrafish model. International conference

KA FAI WILLIAM TSE

The 24th Japanese Medaka and Zebrafish Meeting 2018.8

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Event date： 2018.8

Language：English

Country：Japan
Reactivation of polr1c restores the ethmoid plate structure in zebrafish Type 3 Treacher Collins Syndrome model International conference

KA FAI WILLIAM TSE

The 51st Annual Meeting of the Japanese Society of Developmental Biologists (JSDB) 2018.6

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Event date： 2018.6

Language：English

Country：Japan
The role of POLR1C in Treacher Collins Syndrome International conference

KA FAI WILLIAM TSE

The 23rd Japanese Medaka and Zebrafish Meeting 2017.8

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Event date： 2017.8

Language：English

Country：Japan
Zebrafish model revealed the functional time window of POLR1C on facial development International conference

KA FAI WILLIAM TSE

The 50th Annual Meeting of the Japanese Society of Developmental Biologists (JSDB) 2017.5

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Event date： 2017.5

Language：English

Country：Japan
Zebrafish as the screening model. Invited

KA FAI WILLIAM TSE

Li Ka Shing Faculty of Medicine, The University of Hong Kong 2015.7

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Event date： 2015.7

Language：English Presentation type：Oral presentation (general)
Zebrafish model revealed the pathogenesis of POLR1C Type 3 Treacher Collins Syndrome. International conference

ML KWONG, KA FAI WILLIAM TSE

The 48h Annual Meeting of the Japanese Society of Developmental Biologists

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Event date： 2015.6

Language：English

Country：Japan
Transcriptome analysis of zebrafish polr1c mutant revealed the importance of p53 pathway in Treacher Collins Syndrome. International conference

KA FAI WILLIAM TSE

The 48th Annual Meeting of the Japanese Society of Developmental Biologists

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Event date： 2015.6

Language：English

Country：Japan
Characterization of polr1c in facial development related to the Treacher Collins Syndrome. International conference

CC LAU, KA FAI WILLIAM TSE

The 47th Annual Meeting of the Japanese Society of Developmental Biologists

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Event date： 2014.5

Language：English

Country：Japan
Loss-of-function analysis of deubiquitylating enzymes reveals their importance in zebrafish craniofacial development. International conference

KA FAI WILLIAM TSE

The 47th Annual Meeting of the Japanese Society of Developmental Biologists

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Event date： 2014.5

Language：English

Country：Japan
Zebrafihs TSC22D3 plays critical roles in Bmp dependent dorsoventral patterning during early embryogenesis. International conference

KA FAI WILLIAM TSE

The 46th Annual Meeting of the Japanese Society of Developmental Biologists

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Event date： 2013.5

Language：English Presentation type：Oral presentation (general)

Country：Japan
Developmental roles of deubiquitylating enzymes in zebrafish. International conference

KA FAI WILLIAM TSE

Hong Kong Society for Developmental Biology Symposium: From Embryology to Disease Mechanisms.

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Event date： 2012.11

Language：English
Deubiquitylating Enzymes, Otud4, Usp5, Usp15, and Usp25, are Essential in Zebrafish Dorsoventral Patterning through BMP pathway. International conference

KA FAI WILLIAM TSE, B EISEHABER, SHK HO, QM NG, F EISEHABER, YJ JIANG

Society for Developmental Biology 68th Annual Meeting.

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Event date： 2009.7

Language：English

Country：United States
Identification of 85 deubiquitinating enzymes in zebrafish and their loss-of-function studies by morpholino knockdowns. International conference

KA FAI WILLIAM TSE, B EISEHABER, SHK HO, QM NG, F EISEHABER, YJ JIANG

The 42nd Annual Meeting of the Japanese Society of Developmental Biologists

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Event date： 2009.5

Language：English

Country：Japan
The Characterization of novel mib alleles. International conference

KA FAI WILLIAM TSE, QM NG, YJ JIANG

8th International meeting on zebrafish development and genetics.

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Event date： 2008.6

Language：English

Country：United States
Temporal characterization of ion channels and transporters expressions in gill chloride cells. International conference

KA FAI WILLIAM TSE, MS YANG, CKC WONG

7th International congress on the biology of fish.

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Event date： 2006.7

Language：English

Country：Canada
Effect of dexamethasone on the expressions of Na+/H+ exchanger and Na+/K+-ATPase in primary gill culture of freshwater adapted Japanese eel, Anguilla japonica. International conference

KA FAI WILLIAM TSE, DWT AU, CKC WONG

Comparative endocrinology and biodiversity in Asia and Oceania.

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Event date： 2006.2

Language：English Presentation type：Oral presentation (general)

Country：Thailand
Cadmium and tert-butyl hydroperoxide induced different redox states in HepG2 cells – Their correlation with the mode of cell death. International conference

Society of Toxicology – The 44th annual meeting.

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Event date： 2005.3

Language：English

Venue：New Orleans Country：United States

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Professional Memberships

The Asia-Pacific Developmental Biology Network
Hong Kong Society for Developmental Biology
Japanese Society of Developmental Biology
Hong Kong Society for Developmental Biology

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Japanese Society of Developmental Biology

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The Asia-Pacific Developmental Biology Network

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Committee Memberships

BMC Biology Associate Editor

2023.11 - Present

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BMC Genomics Associate Editor

2018.5 - Present

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Committee type：Other

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九州大学九州大学外国人教員アドバイザリーグループ SHARE-Q International Advisory Group (SIAG)

2022.4 - 2026.3

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Committee type：Other

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九州大学国際卓越研究大学 WG (広報)

2022.4 - 2022.5

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Committee type：Other

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Kyushu University Promotion and networking WG

2021.4 - 2022.3

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Committee type：Other

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Translational Oncology Advisory Board

2020.8 - Present

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Committee type：Other

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Antibiotics Topic Editor

2019.10 - Present

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Committee type：Other

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Academic Activities

Screening of academic papers

Role(s)： Peer review

2024

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：14
BMC Biology International contribution

2023.11 - Present

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Type：Academic society, research group, etc.
Screening of academic papers

Role(s)： Peer review

2023

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：39
Screening of academic papers

Role(s)： Peer review

2022

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：50
Frontiers in Endocrinology International contribution

2021.10 - Present

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Type：Academic society, research group, etc.
Frontiers in Endocrinology International contribution

Role(s)： Review, evaluation

2021.10

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Type：Peer review

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Frontiers in Public Health International contribution

2021.8 - Present

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Type：Academic society, research group, etc.
Frontiers in Public Health International contribution

Role(s)： Review, evaluation

2021.8

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Type：Peer review

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Frontiers in Physiology International contribution

2021.2 - Present

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Type：Academic society, research group, etc.
Frontier in Physiology International contribution

Role(s)： Review, evaluation

2021.2

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Type：Peer review

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Screening of academic papers

Role(s)： Peer review

2021

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：30
Translational Oncology International contribution

Role(s)： Peer review

2020.8 - Present

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Type：Academic society, research group, etc.
Translational Oncology International contribution

Role(s)： Peer review

2020.8

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Type：Peer review

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Chairperson of the Mini-Symposium 1: Developmental Toxicology and Toxicogenomics International contribution

The 53rd Annual Meeting of the Japanese Society of Developmental Biologists （ Kumamoto Japan ） 2020.5

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Type：Competition, symposium, etc.
Screening of academic papers

Role(s)： Peer review

2020

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：50
Antibiotics International contribution

2019.10 - 2021.8

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Type：Academic society, research group, etc.
Antibiotics International contribution

Role(s)： Review, evaluation

2019.10

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Type：Peer review

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Screening of academic papers

Role(s)： Peer review

2019

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：26
BMC Genomics International contribution

2018.5 - Present

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Type：Academic society, research group, etc.
BMC Genomics International contribution

Role(s)： Review, evaluation

2018.5

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Type：Peer review

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Screening of academic papers

Role(s)： Peer review

2018

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：24

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Research Projects

The osmoregulatory function of metabolites from microbiota in medaka

2024.4 - 2025.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
Transgenerational Impact of PFHxS Exposure and its Association with Cancer Development in Indonesia

2024 - 2025

Japan Society for the Promotion of Science

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Authorship：Principal investigator Grant type：Joint research
Unfolding the pathogenesis of craniofacial related intractable diseases by zebrafish model

2023 - 2025

Japan Society for the Promotion of Science Bilateral program

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Authorship：Principal investigator Grant type：Joint research
Effect of osmotic stress on gill micriobiota in medaka

2022.4 - 2023.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
Glutathione modulates the extracellular matrix organization of craniofacial neural crest cells in Type 3 POLR`C Treacher Collins syndrome

Grant number：22K07025 2022 - 2025

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Principal investigator Grant type：Scientific research funding
The impact of microplastics on brain health and reproductive system health and the damage of barrier function

2022 - 2024

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Authorship：Coinvestigator(s) Grant type：Contract research
The role of polr1c in regulating endodermal cells in Type 3 Treacher Collins syndrome

2020.4 - 2023.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
The osmoregulatory mechanism in medaka

2020.4 - 2022.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
Effects of plastic microparticles and their environmental pollutants enrichment on reproductive ability of parents and offspring

2020 - 2022

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Authorship：Coinvestigator(s) Grant type：Contract research
Triclosan: a risk factor of fatty liver disease

2019.4 - 2021.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
The osmoregulatory roles of Ostf1b in medaka

2019.4 - 2020.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
The role of polr1c in regulating endodermal cells in Type 3 Treacher Collins syndrome

2019.4 - 2020.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
Generation of osmotic stress transcription factor 1b knockout medaka for fish osmoregulation studies

2018.4 - 2019.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
The osmoregulatory roles of Ostf1b in medaka

2018.4 - 2019.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
Triclosan: a risk factor of fatty liver disease

2018.4 - 2019.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
水環境の金属酸化物ナノ粒子の発生毒性影響評価

2018 - 2019

公益財団法人クリタ水・環境科学振興財団

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Authorship：Principal investigator Grant type：Contract research
The emerging craniofacial developmental roles of polr1c in Treacher Collins Syndrome

2018 - 2019

Challenging Research Type II Faculty of Agriculture, Kyushu University

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Generation of knockout medaka for fish osmoregulation studies

2017.4 - 2018.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
The potential use of antioxidant to treat the POLR1C-dependent Type 3 Treacher Collins Syndrome.

2017 - 2019

Japan Society for the Promotion of Science Bilateral program

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Authorship：Principal investigator Grant type：Joint research
ゼブラフィッシュ胚を使用した水質検査ガイドラインの確立/To establish the guideline of using zebrafish embryos to monitor the water quality

2017 - 2018

公益財団法人クリタ水・環境科学振興財団/萌芽的研究

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Authorship：Principal investigator Grant type：Contract research
Screening for transgenic craniofacial developmental model for live-imaging.

2015.4 - 2016.3

Joint research

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Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
Role of deubiquitylating enzyme, cops6, in zebrafish craniofacial palatogenesis.

2015 - 2016

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Authorship：Principal investigator Grant type：Contract research
The Role of DUBs in Cancer Metastasis.

2015

Science Faculty Research Fund, Hong Kong Baptist University.

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Characterization of cpt1a in liver development and the generation of cpt1a transgenic zebrafish for environmental toxicology screening.

2015

Science Faculty Research Fund, Hong Kong Baptist University.

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
To Define the Effects of Endocrine-Disrupting Chemicals on Gonadal Sex Development.

2014 - 2016

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Authorship：Coinvestigator(s) Grant type：On-campus funds, funds, etc.
Functional Studies of polr1c in Facial Development.

2014

Science Faculty Research Fund, Hong Kong Baptist University.

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Functions of Deubiquitylating Enzymes on Craniofacial Development.

2014

Science Faculty Research Fund, Hong Kong Baptist University.

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Start-up

2013 - 2016

Hong Kong Baptist University.

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
The Characterization of Novel mib Alleles.

2013

Science Faculty Research Fund, Hong Kong Baptist University.

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Characterization of Treacher Collins syndrome using zebrafish mutant polr1c line.

2013

Science Faculty Research Fund, Hong Kong Baptist University

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Developmental toxicity International coauthorship

2012.1

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Authorship：Principal investigator
Disease model and mechanism International coauthorship

2012.1

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Authorship：Principal investigator
Developmental functions of deubiquitylating enzyme International coauthorship

2009.1

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Authorship：Principal investigator
Osmoregulation and Osmosensing mechanisms in eel mitochondria-rich cells

Grant number：09F09099 2009 - 2011

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

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Grant type：Scientific research funding
Fish Osmoregulation International coauthorship

2006.1

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Authorship：Principal investigator

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Educational Activities

I am involved in five courses in the IUP:

Applied Cell Biology
Bioresource and Bioenvironment Experiments and Practice 1
Fundamental Cell Biology
Physiology
Special Lecture on Advanced Topics of Agriculture 1

Class subject

Applied Cell Biology Ⅱ

2024.12 - 2025.2 Winter quarter
BBEP；Developmental biology and toxicology

2024.10 - 2024.12 Fall quarter
Physiology Ⅰ

2024.10 - 2024.12 Fall quarter
Applied Cell Biology Ⅰ

2024.10 - 2024.12 Fall quarter
Fundamental Cell Biology Ⅱ

2024.6 - 2024.8 Summer quarter
Master's Thesis Research Ⅰ

2024.4 - 2025.3 Full year
Seminar in a Specified Field Ⅰ

2024.4 - 2025.3 Full year
Fundamental Cell Biology Ⅰ

2024.4 - 2024.6 Spring quarter
Applied Cell Biology Ⅱ

2023.12 - 2024.2 Winter quarter
Physiology Ⅰ

2023.10 - 2023.12 Fall quarter
Applied Cell Biology Ⅰ

2023.10 - 2023.12 Fall quarter
BBEP；Developmental biology and toxicology

2023.10 - 2023.12 Fall quarter
Fundamental Cell Biology Ⅱ

2023.6 - 2023.8 Summer quarter
Fundamental Cell Biology Ⅰ

2023.4 - 2023.6 Spring quarter
Bioresource and Bioenvironment Experiments and Practice 1

2022.12 - 2023.2 Winter quarter
Applied Cell Biology

2022.10 - 2022.12 Fall quarter
Bioresource and Bioenvironment Experiments and Practice 1

2022.10 - 2022.12 Fall quarter
Physiology Ⅰ

2022.10 - 2022.12 Fall quarter
Introduction to BBS1 - I

2022.10 - 2022.12 Fall quarter
Applied Cell Biology

2022.10 - 2022.12 Fall quarter
Fundamental Cell Biology Ⅱ

2022.6 - 2022.8 Summer quarter
Fundamental Cell Biology Ⅱ

2022.6 - 2022.8 Summer quarter
Current Topics in Agriculture and Biotechnology

2022.4 - 2023.3 Full year
Fundamental Cell Biology Ⅰ

2022.4 - 2022.6 Spring quarter
Fundamental Cell Biology Ⅰ

2022.4 - 2022.6 Spring quarter
Physiology

2022.4 - 2022.6 Spring quarter
Bioresource and Bioenvironment Experiments and Practice 1

2021.12 - 2022.2 Winter quarter
Applied Cell Biology

2021.10 - 2021.12 Fall quarter
Bioresource and Bioenvironment Experiments and Practice 1

2021.10 - 2021.12 Fall quarter
Physiology

2021.10 - 2021.12 Fall quarter
Applied Cell Biology

2021.10 - 2021.12 Fall quarter
Fundamental Cell Biology Ⅱ

2021.6 - 2021.8 Summer quarter
Fundamental Cell Biology Ⅱ

2021.6 - 2021.8 Summer quarter
Physiology

2021.4 - 2021.6 Spring quarter
Fundamental Cell Biology Ⅰ

2021.4 - 2021.6 Spring quarter
Fundamental Cell Biology Ⅰ

2021.4 - 2021.6 Spring quarter
Physiology

2021.4 - 2021.6 Spring quarter
Bioresource and Bioenvironment Experiments and Practice 1

2020.12 - 2021.2 Winter quarter
Applied Cell Biology

2020.10 - 2020.12 Fall quarter
Applied Cell Biology

2020.10 - 2020.12 Fall quarter
Bioresource and Bioenvironment Experiments and Practice 1

2020.10 - 2020.12 Fall quarter
Fundamental Cell Biology Ⅱ

2020.6 - 2020.8 Summer quarter
Fundamental Cell Biology Ⅱ

2020.6 - 2020.8 Summer quarter
Physiology

2020.4 - 2020.6 Spring quarter
Fundamental Cell Biology Ⅰ

2020.4 - 2020.6 Spring quarter
Fundamental Cell Biology Ⅰ

2020.4 - 2020.6 Spring quarter
Physiology

2020.4 - 2020.6 Spring quarter
Applied Cell Biology

2019.10 - 2019.12 Fall quarter
Bioresource and Bioenvironment Experiments and Practice 1

2019.10 - 2019.12 Fall quarter
Fundamental Cell Biology Ⅱ

2019.6 - 2019.8 Summer quarter
Special Lecture on Advanced Topics of Agriculture 1

2019.4 - 2019.9 First semester
Physiology

2019.4 - 2019.6 Spring quarter
Fundamental Cell Biology Ⅰ

2019.4 - 2019.6 Spring quarter
Applied Cell Biology

2018.10 - 2018.12 Fall quarter
Bioresource and Bioenvironment Experiments and Practice 1

2018.10 - 2018.12 Fall quarter
Introductory Biology

2018.4 - 2019.3 Full year
Special Lecture on Advanced Topics of Agriculture 1

2018.4 - 2018.9 First semester
Bioresource and Bioenvironment Experiments and Practice 1

2017.10 - 2017.12 Fall quarter
Applied Cell Biology

2017.10 - 2017.12 Fall quarter
Special Lecture on Advanced Topics of Agriculture 1

2017.4 - 2017.9 First semester
Introductory Biology

2017.4 - 2017.6 Spring quarter
Special Lecture on Advanced Topics of Agriculture 1

2016.4 - 2016.9 First semester
Introductory Biology

2016.4 - 2016.9 First semester

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Participation in international educational events, etc.

2019.6

Kyushu University/ City University of Hong Kong

Bilateral Exchange Program (Inbound: City University of Hong Kong to Kyushu University)

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Venue：Japan/ Hong Kong

Number of participants：20
2018.12

Kyushu University/ University of New South Wales

Bilateral Exchange Program (Inbound:University of New South Wales to Kyushu University)

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Venue：Japan/ Canada

Number of participants：12
2018.6

Kyushu University/ City University of Hong Kong

Bilateral Exchange Program (Inbound: City University of Hong Kong to Kyushu University)

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Venue：Japan/ Hong Kong

Number of participants：15
2018.3

Kyushu University/ City University of Hong Kong

Bilateral Exchange Program (Outbound:Kyushu University to City University of Hong Kong)

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Venue：Japan/ Hong Kong

Number of participants：9
2017.6

Kyushu University/ City University of Hong Kong

Bilateral Exchange Program (Inbound: City University of Hong Kong to Kyushu University)

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Venue：Japan/ Hong Kong

Number of participants：18
2017.2

Kyushu University/ City University of Hong Kong

Bilateral Exchange Program (Outbound:Kyushu University to City University of Hong Kong)

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Venue：Japan/ Hong Kong

Number of participants：12
2016.6

Kyushu University/ City University of Hong Kong

Bilateral Exchange Program (Inbound: City University of Hong Kong to Kyushu University)

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Venue：Japan/ Hong Kong

Number of participants：21

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Outline of Social Contribution and International Cooperation activities

My group collaborates with different researchers around the world, such as China, Hong Kong, Germany, and Taiwan.

Social Activities

The Application of Fluorescent Proteins in Biology

Kyushu University IUP: Special Webinar for PSHS Students. Manila, Philippines. 2022.9

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Audience： Infants,　Schoolchildren,　Junior students,　High school students

Type：Seminar, workshop
The Application of Fluorescent Proteins in Biology

Kyushu University IUP: Special Webinar for PSHS Students. Manila, Philippines. 2022.9

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Type：Seminar, workshop

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The Application of Fluorescent Proteins in Biology.

Tokyo Gakugei University International Secondary School, Japan 2017.12

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Audience： Infants,　Schoolchildren,　Junior students,　High school students

Type：Seminar, workshop
The Application of Fluorescent Proteins in Biology.

Tokyo Gakugei University International Secondary School, Japan 2017.12

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Type：Seminar, workshop

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東京学芸大学附属国際中等教育学校大学模擬授業

2017

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東京学芸大学附属国際中等教育学校
大学模擬授業
東京学芸大学附属国際中等教育学校大学模擬授業

2017

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Type：Other

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Media Coverage

Lead contamination should spur Hong Kong to review its water safety protocols: William Tse says while officials must act quickly to clean up the lead contamination in our tap water, society as a whole must review protocols to ensure better standards Newspaper, magazine

South China Morning Post (Hong Kong) 2015.7

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Lead contamination should spur Hong Kong to review its water safety protocols:

William Tse says while officials must act quickly to clean up the lead contamination in our tap water, society as a whole must review protocols to ensure better standards

Acceptance of Foreign Researchers, etc.

National Research and Innovation Agency, Republic of Indonesia

Acceptance period： 2023.12 - 2024.4 （Period）：1 month or more

Nationality：Indonesia

Business entity：Foreign governments, foreign research institutes, international organizations
National Research and Innovation Agency, Republic of Indonesia

Acceptance period： 2022.8 - 2023.7 （Period）：1 month or more

Nationality：Indonesia

Business entity：Private/Foundation
Saarland University

Acceptance period： 2019.4 （Period）：2weeks to less than 1 month

Nationality：Germany

Travel Abroad

2019.4

Staying countory name 1：Other Staying institution name 1：City University of Hong Kong
2019.3

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2018.8

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2018.6 - 2018.7

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2018.3

Staying countory name 1：Other Staying institution name 1：City University of Hong Kong
2018.2 - 2018.3

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2017.12

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2017.11

Staying countory name 1：Other Staying institution name 1：City University of Hong Kong
2017.8

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2017.6

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2017.2 - 2017.3

Staying countory name 1：Other Staying institution name 1：City University of Hong Kong
2016.9

Staying countory name 1：Other Staying institution name 1：Hobg Kong Baptist University
2016.8

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2015.8

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2015.2 - 2015.6

Staying countory name 1：China Staying institution name 1：Beijing Normal University-Hong Kong Baptist University, United International College
2014.8

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2013.8

Staying countory name 1：Taiwan, Province of China Staying institution name 1：National Health Research Institutes
2012.6 - 2016.2

Staying countory name 1：Other Staying institution name 1：Hong Kong Baptist University
2011.9 - 2012.6

Staying countory name 1：United States Staying institution name 1：Massachusetts General Hospital, Harvard Medical School
2007.11 - 2009.9

Staying countory name 1：Singapore Staying institution name 1：Institute of Molecular and Cell Biology, A*STAR

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