記述言語：その他   掲載種別：研究論文（学術雑誌）  

<title>Abstract</title>The maladaptive remodeling of vessel walls with neointima formation is a common feature of proliferative vascular diseases. It has been proposed that neointima formation is caused by the dedifferentiation of mature smooth muscle cells (SMCs). Recent evidence suggests that adventitial cells also participate in neointima formation; however, their cellular dynamics are not fully understood. In this study, we utilized a lineage tracing model of platelet-derived growth factor receptor alpha (PDGFRa) cells and examined cellular behavior during homeostasis and injury response. PDGFRa marked adventitial cells that were largely positive for Sca1 and a portion of medial SMCs, and both cell types were maintained for 2 years. Upon carotid artery ligation, PDGFRa-positive (+) cells were slowly recruited to the neointima and exhibited an immature SMC phenotype. In contrast, in a more severe wire denudation injury, PDGFRa+ cells were recruited to the neointima within 14 days and fully differentiated into SMCs. Under pressure overload induced by transverse aortic constriction, PDGFRa+ cells developed marked adventitial fibrosis<bold>.</bold> Taken together<bold>,</bold> our observations suggest that PDGFRa+ cells serve as a reservoir of adventitial cells and a subset of medial SMCs and underscore their context-dependent response to vascular injuries.

DOI： 10.1038/s41598-021-88126-6

リポジトリ公開URL： https://hdl.handle.net/2324/7238368

記述言語：その他   掲載種別：研究論文（学術雑誌）  

Stem cell (SC) proliferation and differentiation organize tissue homeostasis. However, how SCs regulate coordinate tissue scaling in dynamic organs remain unknown. Here, we delineate SC regulations in dynamic skin. We found that interfollicular epidermal SCs (IFESCs) shape basal epidermal proliferating clusters (EPCs) in expanding abdominal epidermis of pregnant mice and proliferating plantar epidermis. EPCs consist of IFESC-derived Tbx3⁺–basal cells (Tbx3⁺-BCs) and their neighboring cells where Adam8–extracellular signal–regulated kinase signaling is activated. Clonal lineage tracing revealed that Tbx3⁺-BC clones emerge in the abdominal epidermis during pregnancy, followed by differentiation after parturition. In the plantar epidermis, Tbx3⁺-BCs are sustained as long-lived SCs to maintain EPCs invariably. We showed that Tbx3⁺-BCs are vasculature-dependent IFESCs and identified mechanical stretch as an external cue for the vasculature-driven EPC formation. Our results uncover vasculature-mediated IFESC regulations, which explain how the epidermis adjusts its size in orchestration with dermal constituents in dynamic skin.

DOI： 10.1126/sciadv.abd2575

リポジトリ公開URL： https://hdl.handle.net/2324/7238340

記述言語：英語   掲載種別：研究論文（学術雑誌）  

<title>ABSTRACT</title>Adult tissues contain label-retaining cells (LRCs), which are relatively slow-cycling and considered to represent a property of tissue stem cells (SCs). In the ocular surface epithelium, LRCs are present in the limbus and conjunctival fornix; however, the character of these LRCs remains unclear, owing to lack of appropriate molecular markers. Using three CreER transgenic mouse lines, we demonstrate that the ocular surface epithelium accommodates spatially distinct populations with different cell division dynamics. In the limbus, long-lived Slc1a3^CreER-labeled SCs either migrate centripetally toward the central cornea or slowly expand their clones laterally within the limbal region. In the central cornea, non-LRCs labeled with Dlx1^CreER and K14^CreER behave as short-lived progenitor cells. The conjunctival epithelium in the bulbar, fornix and palpebral compartment is regenerated by regionally unique SC populations. Severe damage to the cornea leads to the cancellation of SC compartments and conjunctivalization, whereas milder limbal injury induces a rapid increase of laterally expanding clones in the limbus. Taken together, our work defines compartmentalized multiple SC/progenitor populations of the mouse eye in homeostasis and their behavioral changes in response to injury.

DOI： 10.1242/dev.197590

リポジトリ公開URL： https://hdl.handle.net/2324/7238338

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Aging in the epidermis is marked by a gradual decline in barrier function, impaired wound healing, hair loss, and an increased risk of cancer. This could be due to age-related changes in the properties of epidermal stem cells and defective interactions with their microenvironment. Currently, no biochemical tools are available to detect and evaluate the aging of epidermal stem cells. The cellular glycosylation is involved in cell-cell communications and cell-matrix adhesions in various physiological and pathological conditions. Here, we explored the changes of glycans in epidermal stem cells as a potential biomarker of aging. Using lectin microarray, we performed a comprehensive glycan profiling of freshly isolated epidermal stem cells from young and old mouse skin. Epidermal stem cells exhibited a significant difference in glycan profiles between young and old mice. In particular, the binding of a mannose-binder rHeltuba was decreased in old epidermal stem cells, whereas that of an α2-3Sia-binder rGal8N increased. These glycan changes were accompanied by upregulation of sialyltransferase, St3gal2 and St6gal1 and mannosidase Man1a genes in old epidermal stem cells. The modification of cell surface glycans by overexpressing these glycogenes leads to a defect in the regenerative ability of epidermal stem cells in culture. Hence, our study suggests the age-related global alterations in cellular glycosylation patterns and its potential contribution to the stem cell function. These glycan modifications detected by lectins may serve as molecular markers for aging, and further functional studies will lead us to a better understanding of the process of skin aging.

DOI： 10.1111/acel.13190

リポジトリ公開URL： https://hdl.handle.net/2324/7232059

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Histone H3 K4/9/27 trimethylation levels affect wound healing and stem cell dynamics in adult skin

DOI： 10.1016/j.stemcr.2019.11.007

リポジトリ公開URL： https://hdl.handle.net/2324/7238385

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis

DOI： 10.1371/journal.pone.0215908

リポジトリ公開URL： https://hdl.handle.net/2324/7218263

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jid.2017.02.974

リポジトリ公開URL： https://hdl.handle.net/2324/7238386

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The interfollicular epidermis regenerates from heterogeneous basal skin cell populations that divide at different rates. It has previously been presumed that infrequently dividing basal cells known as label-retaining cells (LRCs) are stem cells, whereas non-LRCs are short-lived progenitors. Here we employ the H2B-GFP pulse-chase system in adult mouse skin and find that epidermal LRCs and non-LRCs are molecularly distinct and can be differentiated by Dlx1(CreER) and Slc1a3(CreER) genetic marking, respectively. Long-term lineage tracing and mathematical modelling of H2B-GFP dilution data show that LRCs and non-LRCs constitute two distinct stem cell populations with different patterns of proliferation, differentiation and upward cellular transport. During homeostasis, these populations are enriched in spatially distinct skin territories and can preferentially produce unique differentiated lineages. On wounding or selective killing, they can temporarily replenish each other's territory. These two discrete interfollicular stem cell populations are functionally interchangeable and intrinsically well adapted to thrive in distinct skin environments.

DOI： 10.1038/ncb3359

リポジトリ公開URL： https://hdl.handle.net/2324/7238746

記述言語：英語   掲載種別：研究論文（学術雑誌）  

In many adult tissues, homeostasis relies on self-renewing stem cells that are primed for differentiation. The reconciliation mechanisms of these characteristics remain a fundamental question in stem cell biology. We propose that regulation at the post-transcriptional level is essential for homeostasis in murine spermatogonial stem cells (SSCs). Here, we show that Nanos2, an evolutionarily conserved RNA-binding protein, works with other cellular messenger ribonucleoprotein (mRNP) components to ensure the primitive status of SSCs through a dual mechanism that involves (1) direct recruitment and translational repression of genes that promote spermatogonial differentiation and (2) repression of the target of rapamycin complex 1 (mTORC1), a well-known negative pathway for SSC self-renewal, by sequestration of the core factor mTOR in mRNPs. This mechanism links mRNA turnover to mTORC1 signaling through Nanos2-containing mRNPs and establishes a post-transcriptional buffering system to facilitate SSC homeostasis in the fluctuating environment within the seminiferous tubule.

DOI： 10.1016/j.devcel.2015.05.014

リポジトリ公開URL： https://hdl.handle.net/2324/7232242

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Quiescent hair follicle (HF) bulge stem cells (SCs) differentiate to early progenitor (EP) hair germ (HG) cells, which divide to produce transit-amplifying matrix cells. EPs can revert to SCs upon injury, but whether this dedifferentiation occurs in normal HF homeostasis (hair cycle) and the mechanisms regulating both differentiation and dedifferentiation are unclear. Here, we use lineage tracing, gain of function, transcriptional profiling, and functional assays to examine the role of observed endogenous Runx1 level changes in the hair cycle. We find that forced Runx1 expression induces hair degeneration (catagen) and simultaneously promotes changes in the quiescent bulge SC transcriptome toward a cell state resembling the EP HG fate. This cell-state transition is functionally reversible. We propose that SC differentiation and dedifferentiation are likely to occur during normal HF degeneration and niche restructuring in response to changes in endogenous Runx1 levels associated with SC location with respect to the niche.

DOI： 10.1016/j.celrep.2013.12.039

リポジトリ公開URL： https://hdl.handle.net/2324/7218281

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Stem cells are maintained by both stem cell-extrinsic niche signals and stem cell-intrinsic factors. During murine spermatogenesis, glial cell line-derived neurotrophic factor (GDNF) signal emanated from Sertoli cells and germ cell-intrinsic factor NANOS2 represent key regulators for the maintenance of spermatogonial stem cells. However, it remains unclear how these factors intersect in stem cells to control their cellular state. Here, we show that GDNF signaling is essential to maintain NANOS2 expression, and overexpression of Nanos2 can alleviate the stem cell loss phenotype caused by the depletion of Gfra1, a receptor for GDNF. By using an inducible Cre-loxP system, we show that NANOS2 expression is downregulated upon the conditional knockout (cKO) of Gfra1, while ectopic expression of Nanos2 in GFRA1-negative spermatogonia does not induce de novo GFRA1 expression. Furthermore, overexpression of Nanos2 in the Gfra1-cKO testes prevents precocious differentiation of the Gfra1-knockout stem cells and partially rescues the stem cell loss phenotypes of Gfra1-deficient mice, indicating that the stem cell differentiation can be suppressed by NANOS2 even in the absence of GDNF signaling. Taken together, we suggest that NANOS2 acts downstream of GDNF signaling to maintain undifferentiated state of spermatogonial stem cells. STEM CELLS 2012; 30:280291.

DOI： 10.1002/stem.790

リポジトリ公開URL： https://hdl.handle.net/2324/7238747

記述言語：その他   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0009300

リポジトリ公開URL： https://hdl.handle.net/2324/7173560

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Spermatogonial stem cells (SSCs) reside in undifferentiated type-A spermatogonia and contribute to continuous spermatogenesis by maintaining the balance between self-renewal and differentiation, thereby meeting the biological demand in the testis. Spermatogonia have to date been characterized principally through their morphology, but we herein report the detailed characterization of undifferentiated spermatogonia in mouse testes based on their gene expression profiles in combination with topological features. The detection of the germ cell-specific proteins Nanos2 and Nanos3 as markets of spermatogonia has enabled the clear dissection of complex populations of these cells as Nanos2 was recently shown to be involved in the maintenance of stem cells. Nanos2 is found to be almost exclusively expressed in A(s) to A(pr) cells, whereas Nanos3 is detectable in most undifferentiated spermatogonia (A(s) to A(al)) and differentiating A(1) spermatogonia. In our present study, we find that A(s) and A(pr) can be basically classified into three categories: (1) GFR alpha 1(+)Nanos2(+)Nanos3(-)Ngn3(-), (2) GFR alpha 1(+)Nanos2(+)Nanos3(+)Ngn3(-), and (3) GFR alpha 1(-)Nanos2(+/-)Nanos3(+)Ngn3(+). We propose that the first of these groups is most likely to include the stem cell population and that Nanos3 may function in transit amplifying cells. (C) 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.ydbio.2009.10.002

リポジトリ公開URL： https://hdl.handle.net/2324/7178705

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Stem cells give rise to differentiated cell types but also preserve their undifferentiated state through cell self-renewal. With the use of transgenic mice, we found that the RNA-binding protein NANOS2 is essential for maintaining spermatogonial stem cells. Lineage-tracing analyses revealed that undifferentiated spermatogonia expressing Nanos2 self-renew and generate the entire spermatogenic cell lineage. Conditional disruption of postnatal Nanos2 depleted spermatogonial stem cell reserves, whereas mouse testes in which Nanos2 had been overexpressed accumulated spermatogonia with undifferentiated, stem cell-like properties. Thus, NANOS2 is a key stem cell regulator that is expressed in self-renewing spermatogonial stem cells and maintains the stem cell state during murine spermatogenesis.

DOI： 10.1126/science.1172645

リポジトリ公開URL： https://hdl.handle.net/2324/7178737

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The expression of C/EBP alpha, which may govern transcription of mature hepatocyte marker genes, was suppressed in periportal hepatoblasts in mouse liver development, leading to biliary cell differentiation. This study was undertaken to analyze how inactivation of the Cebpa gene affects biliary cell differentiation and gene expression of the regulatory genes for that differentiation, including Hnf1b and Hnf6. In the knockout mouse liver at midgestation stages, pseudoglandular structures were abundantly induced in the parenchyma with elevated expression of Hnf6 and Hnf1b mRNAs. The wild-type liver parenchyma expressed mRNAs of these transcription factors at low levels, though periportal biliary progenitors had strong expression of them. These results suggest that expression of Hnf6 and Hnf1b is downstream of C/EBP alpha action in fetal liver development, and that the suppression of C/EBP alpha expression in periportal hepatoblasts may lead to expression of Hnf6 and Hnf1b mRNAs. Immunohistochemical studies with biliary cell markers in knockout livers demonstrated that differentiated biliary epithelial cells were confined to around the portal veins. The suppression of C/EBP alpha expression may result in upregulation of Hnf6 and Hnf1b gene expression, but be insufficient for biliary cell differentiation. When liver fragments of Cebpa-knockout fetuses, in which hepatoblasts were contained as an endodermal component, were transplanted in the testis of Scid (Prkdc) male mice, almost all hepatoblasts gave rise to biliary epithelial cells. Wild-type hepatoblasts constructed mature hepatic tissue accompanied by biliary cell differentiation. These results also demonstrate that the suppression of C/EBP alpha expression may stimulate biliary cell differentiation.

DOI： 10.1242/dev.02591

リポジトリ公開URL： https://hdl.handle.net/2324/7178544

開催年月日： 2022年12月

会議種別：シンポジウム・ワークショップ パネル（公募）  

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開催年月日： 2022年11月 - 2022年12月

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Proliferative heterogeneity of epidermal stem cell populations underlying skin regeneration and aging

開催年月日： 2022年11月 - 2022年12月

会議種別：シンポジウム・ワークショップ パネル（指名）  

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開催年月日： 2022年9月

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開催年月日： 2022年9月

会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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開催年月日： 2022年8月

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開催年月日： 2022年8月

会議種別：シンポジウム・ワークショップ パネル（指名）  

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開催年月日： 2022年6月

記述言語：その他  

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開催年月日： 2022年6月

会議種別：シンポジウム・ワークショップ パネル（指名）  

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開催年月日： 2022年5月 - 2022年6月

記述言語：英語  

国名：その他  

開催年月日： 2022年5月 - 2022年6月

記述言語：英語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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開催年月日： 2021年12月

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開催年月日： 2021年11月

記述言語：日本語  

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開催年月日： 2021年10月

記述言語：英語  

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開催年月日： 2021年6月

記述言語：その他  

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The role of Fibulin-7 in the maintenance of mouse skin epidermal stem cells

開催年月日： 2021年6月

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開催年月日： 2021年5月

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開催年月日： 2021年3月

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開催年月日： 2021年2月

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Skin stem cells shuffle sugars as they age: Glycome profiling reveals dynamic glycan alterations during epidermal stem cell aging

開催年月日： 2020年12月

記述言語：その他  

国名：その他  

Protein glycosylation changes in epidermal stem cell aging

開催年月日： 2020年9月

記述言語：その他  

国名：その他  

Defining heterogeneous stem cell populations in oral and eye surface epithelia

開催年月日： 2019年12月

記述言語：日本語  

国名：その他  

開催年月日： 2019年11月

記述言語：その他  

国名：その他  

Differential glycosylation patterns during epidermal stem cell aging

開催年月日： 2019年11月

記述言語：英語  

国名：その他  

Elucidating the cellular and molecular regulation of epidermal stem cell dynamics: from homeostasis to aging

開催年月日： 2019年9月

記述言語：英語  

国名：その他  

Differential glycosylation patterns during epidermal stem cell aging

開催年月日： 2019年9月

記述言語：英語  

国名：その他  

Contribution of PDGFRα-positive cell populations during vascular remodeling

記述言語：その他  

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記述言語：英語  

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Science, Career, and the Future

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記述言語：英語  

開催地：Taiwan   国名：その他  

Differential surface protein modifications during epidermal stem cell aging

記述言語：英語  

国名：その他  

Maintenance of heterogeneous epidermal stem cell populations by the distinct niche

記述言語：日本語  

開催地：淡路   国名：その他  

Maintenance of heterogeneous epidermal stem cell populations by the distinct niche

記述言語：英語  

開催地：Singapore   国名：その他  

Maintenance of heterogeneous epidermal stem cell populations by the distinct niche

記述言語：英語  

国名：その他  

Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis

記述言語：日本語  

開催地：北海道大学電子科学研究所   国名：その他  

Stem cell dynamics in the mouse skin epidermis

記述言語：日本語  

開催地：東京   国名：その他  

Stem cells and glycans

記述言語：日本語  

国名：その他  

記述言語：日本語  

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記述言語：日本語  

開催地：名古屋   国名：その他  

記述言語：日本語  

国名：その他  

表皮の再生と老化を担う幹細胞ダイナミクス

記述言語：英語  

開催地：Japan Kobe   国名：その他  

Defining the stem cell lineages in adult skin epidermis

記述言語：英語  

開催地：Japan Tsukuba   国名：その他  

Differential surface protein modifications during epidermal stem cell aging

記述言語：英語  

開催地：日本 横浜   国名：その他  

Differential surface protein modifications during epidermal stem cell aging

記述言語：英語  

開催地：Taiwan Tainan   国名：その他  

Differential surface protein modifications during epidermal stem cell aging

記述言語：英語  

開催地：Japan Tsukuba   国名：その他  

Differential surface protein modifications during epidermal stem cell aging

記述言語：英語  

開催地：United States Waterville Valley in Waterville Valley, NH   国名：その他  

Maintenance of heterogeneous epidermal stem cell populations by the distinct niche

記述言語：英語  

開催地：United States Waterville Valley in Waterville Valley, NH   国名：その他  

Slc1a3 is expressed in a subset of the heterogeneous stem cell population within the inter follicular epidermis in mouse and human skin

記述言語：英語  

開催地：Japan Tsukuba   国名：その他  

Wild-type and SAMP8 Mice Show Age-Dependent Changes in Distinct Stem Cell Compartments of the Interfollicular Epidermis

記述言語：日本語  

国名：その他  

皮膚の再生を担う幹細胞ダイナミクス～発生から老化まで～

記述言語：日本語  

開催地：日本 横浜   国名：その他  

皮膚恒常性維持と損傷治癒を担う幹細胞の同定：細胞分裂頻度の違いに着眼して

記述言語：日本語  

開催地：日本 横浜   国名：その他  

眼表面上皮における幹細胞ダイナミクス解析

記述言語：日本語  

開催地：日本 京都   国名：その他  

表皮における幹細胞ダイナミクス

記述言語：日本語  

開催地：日本 愛知   国名：その他  

表皮幹細胞の発生、恒常性維持、老化メカニズムの解明

記述言語：英語  

開催地：Japan The University of Tokyo   国名：その他  

Defining the stem cell lineages in the mouse inter-follicular epidermis

記述言語：日本語  

開催地：東京   国名：その他  

マウス表皮幹細胞の同定と制御メカニズムの解明

記述言語：日本語  

国名：その他  

マウス表皮幹細胞を規定する分子マーカーの同定と制御メカニズムの解明

記述言語：日本語  

開催地：日本 横浜   国名：その他  

細胞分裂頻度の違いに着眼したマウス表皮幹細胞の同定

記述言語：英語  

国名：その他  

Defining the stem cell lineages in the mouse inter-follicular epidermis

記述言語：英語  

国名：その他  

Defining the stem cell lineages in the mouse inter-follicular epidermis

記述言語：英語  

国名：その他  

Defining the stem cell lineages in the mouse inter-follicular epidermis

記述言語：英語  

国名：その他  

Defining the stem cell lineages in adult skin epidermis.

記述言語：英語  

開催地：China Hong Kong   国名：その他  

Stem Cell Lineages of the Interfollicular Epidermis.

会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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記述言語：日本語  

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記述言語：日本語  

会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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記述言語：日本語  

会議種別：シンポジウム・ワークショップ パネル（指名）  

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会議種別：口頭発表（招待・特別）  

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会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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記述言語：日本語  

会議種別：シンポジウム・ワークショップ パネル（指名）  

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記述言語：英語   会議種別：口頭発表（招待・特別）  

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会議種別：シンポジウム・ワークショップ パネル（指名）  

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記述言語：英語  

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会議種別：シンポジウム・ワークショップ パネル（指名）  

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会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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会議種別：シンポジウム・ワークショップ パネル（指名）  

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記述言語：日本語   出版者・発行元：日本基礎老化学会  

世界規模で急速に高齢化が進む中、加齢関連疾患の原因究明と克服は大きな課題となっている。皮膚は、外部刺激や異物の侵入から体内を保護するとともに、生体と外部とのインターフェイスとして機能する。一方、加齢に伴い、皮膚のバリア機能や再生能は低下し、がん発症のリスクは増加する。近年、組織の加齢性機能低下の一因として、分化細胞の供給源である幹細胞の老化(ステムセルエイジング)が提唱されている。しかし、幹細胞老化に関する知見の多くは、個々の遺伝子やゲノム制御に着目したもので、解析の難しいタンパク質の修飾やダイナミクスの視点からの研究が遅れている。本稿では、表皮幹細胞の加齢変化を糖鎖の視点から、最新の知見を交えて概説する。表皮幹細胞の老化メカニズムの解明とその克服は、生体内における予防医療への寄与のみならず、幹細胞異常を起因とする皮膚疾患や再生医療上の課題を解決する糸口となることが期待される。(著者抄録)

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

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記述言語：その他  

記述言語：その他  

記述言語：日本語  

上皮コンパートメントの幹細胞と障害に対する応答性の多様性

記述言語：日本語  

皮膚を作る幹細胞の同定・可視化技術

記述言語：日本語  

マウス表皮には分裂頻度の異なる２種類の幹細胞が共存する

記述言語：日本語  

マウス精原幹細胞を制御する分子メカニズム

種別：学会・研究会等 

種別：学会・研究会等 

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種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

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種別：大会・シンポジウム等 

種別：査読等 

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種別：学会・研究会等 

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種別：学会・研究会等 

種別：大会・シンポジウム等 

種別：大会・シンポジウム等 

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種別：大会・シンポジウム等 

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種別：大会・シンポジウム等 

種別：学会・研究会等 

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種別：学会・研究会等 

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種別：大会・シンポジウム等 

種別：学会・研究会等 

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種別：対話型集会・市民会議

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２種類あった幹細胞

定説覆す第2の表皮幹細胞 ―肌の老化・皮膚がん解明に期待