TAKEO MAKOTO
Organization
Medical Institute of Bioregulation Department of Molecular and Cellular Biology Associate Professor
Title
Associate Professor
Contact information
Tel
0926426966
External link
ORCID
Degree
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Ph.D
Papers
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Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair. International journal
Makoto Takeo, Koh-Ei Toyoshima, Riho Fujimoto, Tomoyo Iga, Miki Takase, Miho Ogawa, Takashi Tsuji
Nature communications 14 ( 1 ) 4478 - 4478 2023.8
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Dedifferentiation maintains melanocyte stem cells in a dynamic niche
Qi Sun, Wendy Lee, Hai Hu, Tatsuya Ogawa, Sophie De Leon, Ioanna Katehis, Chae Ho Lim, Makoto Takeo, Michael Cammer, M. Mark Taketo, Denise L. Gay, Sarah E. Millar, Mayumi Ito
Nature 2023.4
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Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration. International journal
Jun Ishikawa, Makoto Takeo, Ayako Iwadate, Junko Koya, Miho Kihira, Masamitsu Oshima, Yuki Suzuki, Kazushi Taniguchi, Ayaka Kobayashi, Takashi Tsuji
Communications biology 4 ( 1 ) 409 - 409 2021.4
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Expansion and characterization of epithelial stem cells with potential for cyclical hair regeneration. International journal
Scientific reports 11 ( 1 ) 1173 - 1173 2021.2
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Tissue-scale tensional homeostasis in skin regulates structure and physiological function. International journal
Shun Kimura, Ayako Tsuchiya, Miho Ogawa, Miki Ono, Nao Suda, Kaori Sekimoto, Makoto Takeo, Takashi Tsuji
Communications biology 3 ( 1 ) 637 - 637 2020.10
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OPN4 belongs to the photosensitive system of the human skin. International journal
Junya Kusumoto, Makoto Takeo, Kazunobu Hashikawa, Takahide Komori, Takashi Tsuji, Hiroto Terashi, Shunsuke Sakakibara
Genes to cells : devoted to molecular & cellular mechanisms 25 ( 3 ) 215 - 225 2020.3
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A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease. International journal
Qi Sun, Wendy Lee, Yasuaki Mohri, Makoto Takeo, Chae Ho Lim, Xiaowei Xu, Peggy Myung, Radhika P Atit, M Mark Taketo, Rana S Moubarak, Markus Schober, Iman Osman, Denise L Gay, Dieter Saur, Emi K Nishimura, Mayumi Ito
Nature communications 10 ( 1 ) 5023 - 5023 2019.11
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Functional ectodermal organ regeneration as the next generation of organ replacement therapy. International journal
Etsuko Ikeda, Miho Ogawa, Makoto Takeo, Takashi Tsuji
Open biology 9 ( 3 ) 190010 - 190010 2019.3
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Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. International journal
Chae Ho Lim, Qi Sun, Karan Ratti, Soung-Hoon Lee, Ying Zheng, Makoto Takeo, Wendy Lee, Piul Rabbani, Maksim V Plikus, Jason E Cain, David H Wang, D Neil Watkins, Sarah Millar, M Mark Taketo, Peggy Myung, George Cotsarelis, Mayumi Ito
Nature communications 9 ( 1 ) 4903 - 4903 2018.11
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Organ regeneration based on developmental biology: past and future. International journal
Makoto Takeo, Takashi Tsuji
Current opinion in genetics & development 52 42 - 47 2018.10
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Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing. International journal
Qi Sun, Piul Rabbani, Makoto Takeo, Soung-Hoon Lee, Chae Ho Lim, En-Nekema Shandi Noel, M Mark Taketo, Peggy Myung, Sarah Millar, Mayumi Ito
The Journal of investigative dermatology 138 ( 7 ) 1591 - 1600 2018.7
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Epithelium-Derived Wnt Ligands Are Essential for Maintenance of Underlying Digit Bone. International journal
Makoto Takeo, Christopher S Hale, Mayumi Ito
The Journal of investigative dermatology 136 ( 7 ) 1355 - 1363 2016.7
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EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling. International journal
Makoto Takeo, Wendy Lee, Piul Rabbani, Qi Sun, Hai Hu, Chae Ho Lim, Prashiela Manga, Mayumi Ito
Cell reports 15 ( 6 ) 1291 - 302 2016.5
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Wound healing and skin regeneration. International journal
Makoto Takeo, Wendy Lee, Mayumi Ito
Cold Spring Harbor perspectives in medicine 5 ( 1 ) a023267 2015.1
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Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling. International journal
Wei Chin Chou, Makoto Takeo, Piul Rabbani, Hai Hu, Wendy Lee, Young Rock Chung, John Carucci, Paul Overbeek, Mayumi Ito
Nature medicine 19 ( 7 ) 924 - 9 2013.7
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Wnt activation in nail epithelium couples nail growth to digit regeneration. International journal
Makoto Takeo, Wei Chin Chou, Qi Sun, Wendy Lee, Piul Rabbani, Cynthia Loomis, M Mark Taketo, Mayumi Ito
Nature 499 ( 7457 ) 228 - 32 2013.7
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Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. International journal
Peggy S Myung, Makoto Takeo, Mayumi Ito, Radhika P Atit
The Journal of investigative dermatology 133 ( 1 ) 31 - 41 2013.1
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Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. International journal
Piul Rabbani, Makoto Takeo, WeiChin Chou, Peggy Myung, Marcus Bosenberg, Lynda Chin, M Mark Taketo, Mayumi Ito
Cell 145 ( 6 ) 941 - 955 2011.6
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grimp, a novel gene required for stem cell proliferation at an initial stage of regeneration in Enchytraeus japonensis (Enchytraeidae, Oligochaete)
Yoshida-Noro Chikako, Takeo Makoto, Noguchi Shota, Tochinai Shin
DIFFERENTIATION 80 S45 - S45 2010.11
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Stem cell system in sexual and asexual reproduction of Enchytraeus japonensis (Oligochaeta, Annelida)
Chikako Yoshida-Noro, Makoto Takeo, Mutsumi Sugio, Shishin Kawamoto, Shin Tochinai
MECHANISMS OF DEVELOPMENT 126 S284 - S284 2009.8
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Morphallactic regeneration as revealed by region-specific gene expression in the digestive tract of Enchytraeus japonensis (Oligochaeta, Annelida). International journal
Makoto Takeo, Chikako Yoshida-Noro, Shin Tochinai
Developmental dynamics : an official publication of the American Association of Anatomists 237 ( 5 ) 1284 - 94 2008.5
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Histological profiling for head and tail determination in regenerating Enchytraeus japonensis
Shishin Kawamoto, Makoto Takeo, Shin Tochinai
ZOOLOGICAL SCIENCE 21 ( 12 ) 1304 - 1304 2004.12
MISC
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毛髪を"種"から再生する未来の再生医療
小川 美帆, 武尾 真, 岡本 尚一, 辻 孝
現代化学 2019.4
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いきものの不思議 ヤマトヒメミミズ--小さな体にひそむ多くの不思議
武尾 真
生物の科学 遺伝 2009.1
Professional Memberships
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Japanese Society of Developmental Biologists
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The Molecular Biology Society of Japan
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The International Society for Regenerative Biology
Research Projects
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keloidal spheroidとシュワン細胞からなるケロイドモデルの作成
Grant number：22K09874 2022 - 2024
日本学術振興会 科学研究費助成事業 基盤研究(C)
Grant type：Scientific research funding
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ニッチスイッチングによる新たな形態リズム創出メカニズムの解明
2022 - 2024
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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三次元器官の生体外構築を目指した哺乳類成体器官における形態形成メカニズムの解明
Grant number：21K12678 2021 - 2023
日本学術振興会 科学研究費助成事業 基盤研究(C)
Grant type：Scientific research funding
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マウス体毛の周期的形態変化を生み出す細胞動態の解明
2020
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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器官形成運命の転換による革新的器官誘導の基盤技術の開発
Grant number：19H01180 2019 - 2021
日本学術振興会 科学研究費助成事業 基盤研究(C)
Grant type：Scientific research funding
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皮膚付属器官を有する三次元再生皮膚器官系の開発
2019 - 2020
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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皮膚付属器官を有する三次元再生皮膚器官系の開発
2019
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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指・四肢再生技術開発に向けた概念実証研究
2018 - 2020
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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指器官再生を目指した器官誘導能を持つ爪間葉の同定と爪器官再生技術の開発
Grant number：18K06944 2018 - 2020
日本学術振興会 科学研究費助成事業 基盤研究(C)
Grant type：Scientific research funding
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器官誘導能をもつ毛包幹細胞の同定をその誘導メカニズムの解明
2018 - 2019
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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皮膚附属器を有する革新的三次元皮膚評価モデル、バイオスキンの開発
Grant number：16H01851 2016 - 2018
日本学術振興会 科学研究費助成事業 基盤研究(C)
Grant type：Scientific research funding
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器官誘導能をもつ毛包幹細胞の同定と分子機構の解明
Grant number：16H07454 2016 - 2017
日本学術振興会 科学研究費助成事業 基盤研究(C)
Grant type：Scientific research funding