Updated on 2024/10/03

Information

 

写真a

 
FUKUI YOSHINORI
 
Organization
Medical Institute of Bioregulation Department of Immunobiology and Neuroscience Professor
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426828
Profile
Remodeling of the actin cytoskeleton is a fundamental biological response that regulates various cellular functions in the immune system. The aim of my research is to elucidate the mechanism by which remodeling of the actin cytoskeleton is induced in lymphoid and myeloid cells downstream of various receptors, and to define its relevance to cellular functions. This accomplishment will lead to the development of new therapeutics for intractable diseases such as autoimmune diseases, graft rejection and infectious diseases.
External link

Degree

  • Doctor of Medical Science

Research Interests・Research Keywords

  • Research theme:Remodeling of the actin cytoskeleton in the immune system

    Keyword:cytoskeleton, cell migration, antigen recognition, development of the immune system, G proteins

    Research period: 2001.1

Awards

  • 文部科学大臣表彰科学技術賞

    2013.4   文部科学省   免疫応答に重要な細胞骨格制御因子の研究

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    細胞運動、貪食、抗原認識といった免疫応答の根幹を為す種々の細胞高次機能は、低分子量Gタンパク質を介した、細胞骨格の再構築により巧妙に制御されている。低分子量Gタンパク質の中でもとりわけRacは、免疫細胞の遊走や活性化に重要な役割を演じているが、Rac自身の活性化を担う因子は長らく不明であった。
     本研究では、通常と異なる構造を持つ、非古典的Rac活性化分子としてDOCK2を同定し、ノックアウトマウスを作製することで、DOCK2が免疫細胞の遊走・分化・活性化に重要な役割を演じることを明らかにした。また、新たな実験系を開発することで、DOCK2の細胞内局在が2つの異なるリン脂質により連続的に制御されていることを見いだし、DOCK2の細胞骨格制御機構の一端を解明した。さらに、DOCK2の欠損により、移植片の拒絶や自己免疫疾患の発症がブロックできることを実証すると共に、DOCK2によるRac活性化を効果的にブロックできる制御化合物を同定した。
     本成果は、自己免疫疾患や移植片拒絶といった免疫病の新しい治療法・予防法の開発に貢献することが期待される。

  • 日本免疫学会賞

    2003.12   日本免疫学会   T細胞の分化・活性化を制御する抗原認識の分子基盤

Papers

  • DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis. Reviewed International journal

    Kazufumi Kunimura , Sayaka Akiyoshi, Takehito Uruno, Keisuke Matsubara, Daiji Sakata, Kenji Morino, Kenichiro Hirotani, Yoshinori Fukui

    J. Allergy Clin. Immunol.   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury. Reviewed International journal

    Kenji Morino, Kazufumi Kunimura, Yuki Sugiura, Yoshihiro Izumi, Keisuke Matsubara, Sayaka Akiyoshi, Rae Maeda, Kenichiro Hirotani, Daiji Sakata, Seiya Mizuno, Satoru Takahashi, Takeshi Bamba, Takehito Uruno, Yoshinori Fukui

    Front. Immunol.   - 14:1131146   2023.3

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  • DOCK2 is involved in the host genetics and biology of severe COVID-19 Reviewed International journal

    Nature   - 609:754-760   2022.8

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  • Identification of a functional DOCK8 gene polymorphism associated with atopic dermatitis Reviewed International journal

    Kazufumi Kunimura, Kazuhiko Yamamura, Takeshi Nakahara, Makiko Kido-Nakahara, Takehito Uruno, Yoshinori Fukui

    Allergy   - 77:3670-3672   2022.7

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  • Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity Reviewed International journal

    Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Kounosuke Oisaki, Daisuke Takaya, Daiji Sakata, Yoshihiro Izumi, Takaya Togo, Yuko Hattori, Kazufumi Kunimura, Tetsuya Sakurai, Teruki Honma, Takeshi Bamba, Masafumi Nakamura, Motomu Kanai, Makoto Suematsu, Yoshinori Fukui

    Biochem. Biophys. Res. Commun.   - 609:183-188   2022.6

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  • Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells. Reviewed International journal

    Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Daiji Sakata, Yoshihiro Izumi, Tetsuya Sakurai, Yuko Hattori, Eiji Oki, Naoto Kubota, Koshiro Nishimoto, Masafumi Oyama, Kazufumi Kunimura, Takuto Ohki, Takeshi Bamba, Hideaki Tahara, Michiie Sakamoto, Masafumi Nakamura, Makoto Suematsu, Yoshinori Fukui

    Int. Immunol.   - 34:277-289   2022.4

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  • The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. Reviewed International journal

    Kazufumi Kunimura, Yoshinori Fukui

    Int. Immunol.   736   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 33

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  • DOCK8 dificiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells. Reviewed International journal

    Keisuke Matsubara, Kazufumi Kunimura, Nana Yamane, Ryosuke Aihara, Tetsuya Sakurai, Daiji Sakata, Takehito Uruno, Yoshinori Fukui

    Biochem. Biophys. Res. Commun.   140   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 559

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  • Target inhibition of EPAS1-driven IL-31 production by a small-molecule compound. Reviewed International journal

    Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui

    J. Allergy Clin. Immun.   638 - in press   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 148

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  • DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation. Reviewed International journal

    Ryosuke Aihara, Kazufumi Kunimura, Mayuki Watanabe, Takehito Uruno, Nana Yamane, Tetsuya Sakurai, Daiji Sakata, Fusanori Nishimura, Yoshinori Fukui

    Int. Immunol.   160   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 33

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  • A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8. Reviewed International journal

    Tetsuya Sakurai, Mutsuko Kunimoto-Niino, Kazufumi Kunimura, Nana Yamane, Daiji Sakata, Ryosuke Aihara, Tomoharu Yasuda, Shigeyuki Yokoyama, Mikako Shirouzu, Yoshinori Fukui, Takehito Uruno

    Life Sci. Alliance   4   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 4

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  • S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches Reviewed International journal

    Kazufumi Kunimura, Daiji Sakata, Xin Tun, Takehito Uruno, Miho Ushijima, Tomoya Katakai, Akira Shiraishi, Ryosuke Aihara, Yasuhisa Kamikaseda, Keisuke Matsubara, Hirokazu Kanegane, Shinichiro Sawa, Gerard Eberl, Shouichi Ohga, Yasunobu Yoshikai, Yoshinori Fukui

    Cell Rep.   9   28340000000   2019.11

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    https://doi.org/10.1016/j.celrep.2019.10.091

    DOI: 26

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  • Selective role of neurokinin B in IL-31-induced itch response in mice Reviewed International journal

    Daiji Sakata, Takehito Uruno, Keisuke Matsubara, Tsugunobu Andoh, Kazuhiko Yamamura, Yuki Magoshi, Kazufumi Kunimura, Yasuhisa Kamikaseda, Masutaka Furue, Yoshinori Fukui

    J. Allergy. Clin. Immunol.   4   113300000000   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    https://doi.org/10.1016/j.jaci.2019.06.031

    DOI: 144

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  • DOCK-family proteins : key players in immune surveillance mechanisms Reviewed International journal

    Kazufumi Kunimura, Takehito Uruno, Yoshinori Fukui

    Int. Immunol.   2019.10

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    https://doi.org/10.1093/intimm/dxz067

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  • Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye Reviewed

    Tetsuya Sakurai, Takehito Uruno, Takaaki Tatsuguchi, Kazuhiko Yamamura, Miho Ushijima, Yuko Hattori, Mutsuko Kukimoto-Niino, Chiemi Mishima-Tsumagari, Mayuki Watanabe, Makoto Suematsu, Yoshinori Fukui

    Sci. Signal.   541   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    https://doi.org/10.1126/scisignal.aao4874

    DOI: 11

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  • Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis Reviewed

    Masutaka Furue, K. Yamamura, Makiko Nakahara, Takeshi Nakahara, Yoshinori Fukui

    Allergy: European Journal of Allergy and Clinical Immunology   1 ( 29-36 )   36   2018.1

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    https://doi.org/10.1111/all.13239

    DOI: 73

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  • A functional genomics predictive network model identifies regulators of inflammatory bowel disease Reviewed

    Lauren A. Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won Min Song, Eric M. Neiman, Sean R. Llewellyn, Antonio Di Narzo, Brian A. Kidd, Shannon E. Telesco, Yongzhong Zhao, Aleksandar Stojmirovic, Jocelyn Sendecki, Khader Shameer, Riccardo Miotto, Bojan Losic, Hardik Shah, Eunjee Lee, Minghui Wang, Jeremiah J. Faith, Andrew Kasarskis, Carrie Brodmerkel, Mark Curran, Anuk Das, Joshua R. Friedman, Yoshinori Fukui, Mary Beth Humphrey, Brian M. Iritani, Nicholas Sibinga, Teresa K. Tarrant, Carmen Argmann, Ke Hao, Panos Roussos, Jun Zhu, Bin Zhang, Radu Dobrin, Lloyd F. Mayer, Eric E. Schadt

    Nature Genetics   10 ( 1437-1449 )   1449   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    https://doi.org/10.1038/ng.3947

    DOI: 49

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  • Thymic epithelial cell?specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes Reviewed

    Toyoshi Yanagihara, Takahiro Tomino, Takehito Uruno, Yoshinori Fukui

    Biochemical and Biophysical Research Communications   1 ( 44055 )   13   2017.7

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    https://doi.org/10.1016/j.bbrc.2017.05.113

    DOI: 489

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  • Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1 Reviewed

    Hirotada Tajiri, Takehito Uruno, Takahiro Shirai, Daisuke Takaya, Shigeki Matsunaga, Daiki Setoyama, Mayuki Watanabe, Mutsuko Kukimoto-Niino, Kounosuke Oisaki, Miho Ushijima, Fumiyuki Sanematsu, Teruki Honma, Takaho Terada, Eiji Oki, Senji Shirasawa, Yoshihiko Maehara, Dongchon Kang, Jean Fran?ois C?t?, Shigeyuki Yokoyama, Motomu Kanai, Yoshinori Fukui

    Cell Reports   5 ( 969-980 )   980   2017.5

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    https://doi.org/10.1016/j.celrep.2017.04.016

    DOI: 19

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  • DOCK8 protein regulates macrophage migration through Cdc42 protein activation and LRAP35a protein interaction Reviewed

    Akira Shiraishi, Takehito Uruno, Fumiyuki Sanematsu, Miho Ushijima, Daiji Sakata, Toshiro Hara, Yoshinori Fukui

    Journal of Biological Chemistry   6 ( 2191-2202 )   2202   2017.2

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    https://doi.org/10.1074/jbc.M116.736306

    DOI: 292

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  • The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction Reviewed

    Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido-Nakahara, Ikuya Tsuge, Masutaka Furue, Yoshinori Fukui

    Nature communications   2017.1

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    https://doi.org/10.1038/ncomms13946

    DOI: 8

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  • Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis. Reviewed International journal

    Toyoshi Yanagihara, Kentaro Hata, Keisuke Matsubara, Kazufumi Kunimura, Kunihiro Suzuki, Kazuya Tsubouchi, Satoshi Ikegame, Yoshihiro Baba, Yoshinori Fukui, Isamu Okamoto

    eLife   12   2024.4

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    DOI: 10.7554/elife.87288.4

  • The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses. Reviewed International journal

    Kirsti Hornigold, Martin J Baker, Polly A Machin, Stephen A Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C E Welch

    Front. Immunol.   - 14:1223653   2023.11

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  • Mass cytometry analysis of B-cell populations in extranodal marginal-zone lymphoma of mucosa-associated lymphoid tissue of the lung. Reviewed International journal

    Toyoshi Yanagihara, Kentaro Hata, Keisuke Matsubara, Kazufumi Kunimura, Kunihiro Suzuki, Kazuya Tsubouchi, Satoshi Ikegame, Yoshihiro Baba, Yoshinori Fukui, Isamu Okamoto

    Ann Hematol.   10   2961   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 102

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  • Altered macrophage phenotypes in a case of autoimmune pulmonary alveolar proteinosis. Reviewed International journal

    Kentaro Hata, Toyoshi Yanagihara, Keisuke Matsubara, Kazufumi Kunimura, Daisuke Eto, Kunihiro Suzuki, Kazuya Tsubouchi, Satoshi Ikegame, Yoshinori Fukui, Isamu Okamoto

    ERJ Open Research   - in press   2023.9

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  • Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1. Reviewed International journal

    Yoshihiro Ueda , Koichiro Higasa, Yuji Kamioka, Naoyuki Kondo, Shunsuke Horitani, Yoshiki Ikeda Wolfgang Bergmeier, Yoshinori Fukui, Tatsuo Kinashi

    iScience   8   - 107292   2023.8

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    DOI: 26

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  • Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis. Reviewed International journal

    Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch

    Front. Immunol.   - in press   2023.6

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  • Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor. Reviewed International journal

    Mutsuko Kukimoto-Niino, Kentaro Ihara, Chiemi Mishima-Tsumagari, Mio Inoue, Yoshinori Fukui, Shigeyuki Yokoyama, Mikako Shirouzu

    Biochem. Biophys. Res. Commun.   - 653:12-20   2023.4

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  • Expansion of ST2-expressing macrophages in a patient with bronchiolitis obliterans syndrome. Reviewed International journal

    Toyoshi Yanagihara, Kentaro Hata, Kunihiro Suzuki, Keisuke Matsubara, Kazufumi Kunimura, Kazuya Tsubouchi, Daisuke Eto, Hiroyuki Ando, Maki Uehara, Satoshi Ikegame, Yoshinori Fukui, Isamu Okamoto

    ERJ Open Research   - 9:00033-2023   2023.3

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  • Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseases. Reviewed International journal

    Kentaro Hata, Toyoshi Yanagihara, Keisuke Matsubara, Kazufumi Kunimura, Kunihiro Suzuki , Kazuya Tsubouchi, Daisuke Eto, Hiroyuki Ando , Maki Uehara , Satoshi Ikegame , Yoshihiro Baba , Yoshinori Fukui , Isamu Okamoto

    Front. Immunol.   - 14: 1145814   2023.3

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  • Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Reviewed International journal

    Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, Chikara Meno, Eri Nakamura, Norihiro Tada, Yoshinori Fukui, Junichi Kikuta, Masaru Ishii, Yukihiko Sugimoto, Mitsuyoshi Nakao, Takehiko Yokomizo

    Cell. Mol. Immunol.   1449   2020.9

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    DOI: 18

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  • Cul5-type ubiquitin ligase KLHDC1 contributes to the elimination of truncated SELEONS produced by failed UGA/Sec decoding. Reviewed International journal

    Fumiko Okumura, Yuha Fujiki, Nodoka Oki, Kana Osaki, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura

    iScience   3   2020.3

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    DOI: 23

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  • Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation Reviewed

    Kazuhito Gotou, Takafumi Morisaki, Daiki Setoyama, Katsuhiko Sasaki, Mikako Yagi, Ko Igami, Soichi Mizuguchi, Takeshi Uchiumi, Yoshinori Fukui, Dongchon Kang

    Cell Rep.   7 ( 1800-1815.e4 )   18150000   2018.11

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    https://doi.org/10.1016/j.celrep.2018.10.057

    DOI: 25

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  • DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1 P29S mutation. Reviewed

    Takahiro Tomino, Hirotada Tajiri, Takaaki Tatsuguchi, Takahiro Shirai, Kounosuke Oisaki, Shigeki Matsunaga, Fumiyuki Sanematsu, Daiji Sakata, Tomoharu Yoshizumi, Yoshihiko Maehara, Motomu Kanai, Jean Fran?ois Cote, Yoshinori Fukui, Takehito Uruno

    Biochem. Biophys. Res. Commun.   1 ( 298-304 )   304   2018.2

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    https://doi.org/10.1016/j.bbrc.2018.02.073

    DOI: 497

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  • The rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production. Reviewed

    Miho Ushijima, Takehito Uruno, Akihiko Nishikimi, Fumiyuki Sanematsu, Yasuhisa Kamikaseda, Kazufumi Kunimura, Daiji Sakata, Takaharu Okada, Yoshinori Fukui

    Front. Immunol.   FEB   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    https://doi.org/10.3389/fimmu.2018.00243

    DOI: 9

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  • The AP-1 transcription factor JunB is required for Th17 cell differentiation Reviewed

    Soh Yamazaki, Yoshihiko Tanaka, Hiromitsu Araki, Akira Kohda, Fumiyuki Sanematsu, Tomoko Arasaki, Xuefeng Duan, Fumihito Miura, Takaharu Katagiri, Ryodai Shindo, Hiroyasu Nakano, Takashi Ito, Yoshinori Fukui, Shogo Endo, Hideki Sumimoto

    Scientific Reports   1   2017.12

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    https://doi.org/10.1038/s41598-017-17597-3

    DOI: 7

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  • Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2 Reviewed

    Fumihiko Okumura, Akiko Joo-Okumura, Keisuke Obara, Alexander Petersen, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura

    Molecular Biology of the Cell   24 ( 3532-3541 )   3541   2017.11

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    https://doi.org/10.1091/mbc.E17-07-0450

    DOI: 28

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  • Corrigendum to “Thymic epithelial cell-specific deletion of Jmjd6 reduces aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes” [Biochemical and Biophysical Research Communications 489/1 (2017) 8?13] (S0006291X1730997X) (10.1016/j.bbrc.2017.05.113) Reviewed

    4   2017.9

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    The authors regret to say that they found a minor mistake in their article.

    DOI: 491

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  • Antigen availability and DOCK2-driven motility govern CD4+ t cell interactions with dendritic cells in vivo Reviewed

    Markus Ackerknecht, Kathrin Gollmer, Philipp Germann, Xenia Ficht, Jun Abe, Yoshinori Fukui, Jim Swoger, Jorge Ripoll, James Sharpe, Jens V. Stein

    Journal of Immunology   2 ( 520-530 )   530   2017.7

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    https://doi.org/10.4049/jimmunol.1601148

    DOI: 199

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  • Correction Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse [The Journal of Experimental Medicine, 210, 12, November 18, (2013) 2721-2737]doi 10.1084/jem.20131324 Reviewed

    Audrey Le Floc'h, Yoshihiko Tanaka, Niels S. Bantilan, Guillaume Voisinne, Gr?goire Altan-Bonnet, Yoshinori Fukui, Morgan Huse

    Journal of Experimental Medicine   4   2017.4

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    https://doi.org/10.1084/jem.2013132403102017c

    DOI: 214

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  • Parallel regulation of von Hippel-Lindau disease by pVHL-mediated degradation of B-Myb and hypoxia-inducible factor α Reviewed

    12 ( 1803-1817 )   1817   2016.6

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    pVHL, the protein product of the von Hippel-Lindau (VHL) tumor suppressor gene, is a ubiquitin ligase that targets hypoxiainducible factor α (HIF-α) for proteasomal degradation. Although HIF-α activation is necessary for VHL disease pathogenesis, constitutive activation of HIF-α alone did not induce renal clear cell carcinomas and pheochromocytomas in mice, suggesting the involvement of an HIF-α-independent pathway in VHL pathogenesis. Here, we show that the transcription factor B-Myb is a pVHL substrate that is degraded via the ubiquitin-proteasome pathway and that vascular endothelial growth factor (VEGF)- and/or platelet-derived growth factor (PDGF)-dependent tyrosine 15 phosphorylation of B-Myb prevents its degradation. Mice injected with B-Myb knockdown 786-O cells developed dramatically larger tumors than those bearing control cell tumors. Microarray screening of B-Myb-regulated genes showed that the expression of HIF-α-dependent genes was not affected by B-Myb knockdown, indicating that B-Myb prevents HIF-α-dependent tumorigenesis through an HIF-α-independent pathway. These data indicate that the regulation of B-Myb by pVHL plays a critical role in VHL disease.

    DOI: 36

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  • DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection Reviewed

    Zhiping Liu, Si Ming Man, Qifan Zhu, Peter Vogel, Sharon Frase, Yoshinori Fukui, Thirumala Devi Kanneganti

    Scientific reports   2016.6

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    https://doi.org/10.1038/srep27814

    DOI: 6

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  • ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation Reviewed

    Keiji Uematsu, Fumihiko Okumura, Syunsuke Tonogai, Akiko Joo-Okumura, Dawit Hailu Alemayehu, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura

    Journal of Cell Biology   1   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    https://doi.org/10.1083/jcb.201603062

    DOI: 215

    Other Link: 公開

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Books

  • T細胞レセプターとMHC分子「免疫学イラストレイテッド」

    福井宣規( Role: Joint translator)

    2009.1 

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    Book type:General book, introductory book for general audience

  • T細胞による抗原の認識「エッセンシャル免疫学」

    福井宣規( Role: Joint translator)

    メディカル・サイエンス・インターナショナル  2007.4 

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    Responsible for pages:p67-96   Language:Japanese   Book type:Scholarly book

  • 抗原提示細胞「戸田新細菌学」

    福井宣規( Role: Joint author)

    南山堂  2007.4 

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    Responsible for pages:p390-399   Language:Japanese   Book type:Scholarly book

  • Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological serf-tolerance.

    Sakaguchi S, Hori S, Fukui Y, Sasazuki T, Sakaguchi N, Takahashi T( Role: Joint author)

    Novartis Found Symp.  2003.6 

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    Language:English   Book type:Scholarly book

  • Contribution of MHC and non-MHC loci to the susceptibility to the organ-specific autoimmune disease

    Sasazuki T, Fukui Y( Role: Joint author)

    Hogrefe & Huber Publishers  2000.1 

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    Language:English   Book type:Scholarly book

  • Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand in vivo

    Sasazuki T, Fukui Y( Role: Joint author)

    Oxford University Press  1997.1 

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    Language:English   Book type:Scholarly book

  • 遺伝子導入で動物を作り変える

    福井宣規、笹月健彦( Role: Joint author)

    医学書院  1993.1 

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    Responsible for pages:pp1-8   Language:Japanese   Book type:Scholarly book

  • T cell repertoire and self-tolerance in the transgenic mice with HLA-DRA on X chromosome.

    Fukui Y, Esaki Y, Yasunami M, Kimura A, Hirokawa K, Nishimura Y, Sasazuki T( Role: Joint author)

    Oxford University Press  1992.1 

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    Responsible for pages:pp648-650   Language:English   Book type:Scholarly book

  • Functional expression of HLA-DQ4 genes in a line of transgenic C57BL/6 mouse

    Esaki Y, Fukui Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T( Role: Joint author)

    Oxford University Press  1992.1 

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    Responsible for pages:pp651-653   Language:English   Book type:Scholarly book

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Presentations

  • Immune regulatory functions of DOCK family proteins in health and disease. Invited International conference

    Germany-Japan Immunology Seminar  2013.12 

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    Event date: 2013.12 - 2012.12

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Immune regulatory functions of DOCK family proteins in health and disease Invited International conference

    Post-GCOE Symposium and Retreat in Singapore  2013.3 

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    Event date: 2013.3 - 2012.3

    Presentation type:Oral presentation (general)  

    Country:Other  

  • 免疫細胞の遊走・活性化におけるDOCKファミリー分子の役割とその制御 Invited

    福井 宣規

    さきがけ 領域会議 特別講演  2013.1 

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    Event date: 2013.1 - 2012.1

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 免疫系細胞高次機能を司るCDMファミリー分子DOCK2-その分子基盤と創薬への応用- Invited

    福井宣規

    平成23年度ターゲットタンパク研究プログラム公開シンポジウム  2012.3 

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    Event date: 2012.3

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 樹状細胞の遊走・活性化におけるDOCKファミリー分子の役割とその制御 Invited

    福井宣規

    第32回和漢医薬学総合研究所特別セミナー「和漢薬治療のターゲットとしての粘膜免疫機構」  2011.12 

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    Event date: 2011.12

    Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  • Role of phospholipid in DOCK family protein-mediated cellular functions Invited

    Fukui Y, Sanematsu F, Nishikimi A

    2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Immune regulatory functions of DOCK2 in health and disease. International conference

    Fukui Y

    ESF-JSPS Frontier Science Conference Series for Young Researchers  2011.3 

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    Event date: 2011.3

    Presentation type:Oral presentation (general)  

    Country:Netherlands  

  • Immune regulatory functions of DOCK2 in health and disease. International conference

    Fukui Y

    7th Global COE International Symposium  2011.2 

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    Event date: 2011.2

    Presentation type:Oral presentation (general)  

    Country:Singapore  

  • Regulation of leukocyte migration and activation by the CDM family protein DOCK2 -From the molecular basis to its clinical application- International conference

    Fukui Y

    The 2010 Fall Conference of The Korean Association of Immunologists  2010.11 

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    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • 細胞骨格制御シグナルを標的とした免疫難病治療の新戦略

    福井宣規

    CREST「免疫機構」研究領域・第一回シンポジウム  2010.10 

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    Event date: 2010.10

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Signaling and function of the CDM family protein DOCK2. International conference

    Fukui Y

    2010.9 

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    Event date: 2010.9

    Presentation type:Symposium, workshop panel (public)  

    Country:Germany  

  • CDMファミリー分子を介した細胞運動の制御とその機能的意義

    福井宣規

    がん特定研究5領域合同シンポジウム  2010.1 

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    Event date: 2010.1

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 免疫系細胞高次機能を司るCDMファミリー分子DOCK2 Invited

    福井宣規

    第1回膜生物学Global COE Students-Organized Symposium  2009.11 

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    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • Critical roles of the CDM family protein DOCK2 in the immune system Invited International conference

    Fukui Y

    The First CSI/JSI/KAI Joint Symposium on Immunology  2009.11 

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    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Country:China  

  • Molecular mechanism controlling intracellular DOCK2 dynamics during neutrophil chemotaxis Invited International conference

    Fukui Y

    The 3rd Global COE International Symposium  2009.2 

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    Event date: 2009.2

    Country:Singapore  

  • 免疫難病治療の新しい分子標的としてのDOCK2 Invited

    福井宣規

    第58回日本アレルギー学会秋季学術大会  2008.11 

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    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Immune regulatory function of DOCK2 in health and disease Invited

    Fukui Y

    Japan-German Immunology Seminar 2008  2008.11 

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    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 自然免疫システムにおけるDOCK2の役割

    福井宣規

    第32回阿蘇シンポジウム  2008.8 

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    Event date: 2008.8

    Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 免疫系細胞高次機能を司るDOCK2シグナルネットワーク

    福井宣規

    第4回ゲノムネットワークプロジェクト公開シンポジウム  2008.2 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • A novel cytoskeleton-regulating protein, DOCK2: its critical role in migration and function of lymphocytes Invited International conference

    Fukui Y. and Sasazuki T

    International Workshop Kyoto T cell Conference  2002.4 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Critical roles of the CDM family protein DOCK2 in migration and function of lymphoyctes. Invited International conference

    Fukui Y

    The Awaji International Forum on Infection and Immunity  2002.8 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Remodeling of actin cytoskeleton by the CDM family protein DOCK2: its critical role in migration and function of lymphocytes Invited International conference

    Fukui Y

    International Symposium on Regulation of Immune Response in Health and Disease  2003.2 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • MHCによるT細胞レパートリー選択の分子機構と自己免疫疾患 Invited

    福井宣規、笹月健彦

    日本医学会総会  2003.5 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • T細胞の分化・活性化を制御する抗原認識の分子基盤 Invited

    福井 宣規

    日本免疫学会  2003.12 

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    Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • Remodeling of the actin cytoskeleton by the CDM family protein DOCK2: its critical role in migration and function of lymphocytes Invited

    Fukui Y

    2003.12 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Signaling and function of DOCK2, a regulator of the actin cytoskeleton in lymphocytes Invited International conference

    Fukui Y

    German-Japan Immunology Symposium  2003.12 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • リンパ球細胞高次機能を司るCDMファミリー分子DOCK2 Invited

    福井宣規

    日本蛋白質学会  2005.7 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Remodeling of the actin cytoskeleton in the immune system Invited International conference

    Yoshinori Fukui

    8th FIMSA/IIS advanced immunology course  2006.2 

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    Presentation type:Oral presentation (general)  

    Country:India  

  • CDMファミリー分子DOCK2による好中球遊走の制御機構 Invited

    福井宣規

    日本分子生物学会2006フォーラム  2006.12 

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    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • DOCK2 is a Rac activator critical for neutrophil chemotaxis Invited

    2006.12 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 免疫系細胞高次機能を司るCDMファミリー分子DOCK2 Invited

    福井宣規

    第18回フォーラム・イン・ドージン「感染症をめぐる宿主の応答と微生物の戦略」  2007.11 

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    Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury.

    The 52nd Annual Meeting of The Japanese Society for Immunology  2024.1 

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    Event date: 2024.1

    Language:English  

    Country:Japan  

  • Pathogenesis of allergic airway inflammation caused by DOCK2 deficiency.

    The 52nd Annual Meeting of The Japanese Society for Immunology  2024.1 

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    Event date: 2024.1

    Language:English  

    Country:Japan  

  • Identificaton of a functional DOCK8 gene polymorphism associated with atopic dermatitis.

    The 52nd Annual Meeting of The Japanese Society for Immunology  2024.1 

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    Event date: 2024.1

    Language:English  

    Country:Japan  

  • 母体-胎児間インターフェイスにおける免疫特権環境形成の新展開 Invited

    福井宣規

    第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • 免疫組織染色により診断し得た high-grade VUE(Villitis of Unknown Etiology)の一例

    廣谷賢一郎、國村和史、岩崎 健、福井宣規、加藤聖子

    第31回日本胎盤学会学術集会/第41回日本絨毛性疾患研究会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • DOCK2/DOCK8分子を介した多彩な免疫制御メカニズム

    國村和史、宇留野武人、福井宣規

    第96回日本生化学会大会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • A mechanism that grants immune privilege at the feto-maternal interface Invited International conference

    2023.10 

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    Event date: 2023.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • DOCK2は肥満細胞のMRGPRX2/B2介在性脱顆粒と薬剤誘発性アナフィラキシーを制御する International conference

    國村和史、福井宣規

    第18回生命医科学研究所ネットワーク国際シンポジウム  2023.10 

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    Event date: 2023.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • がん免疫療法に対する抵抗性を付与する腫瘍メタボライト

    宇留野武人、竜口崇明、杉浦悠毅、福井宣規

    第27回日本がん免疫学会総会  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重   Country:Japan  

  • 母体−胎児間インターフェイスにおける免疫特権環境形成メカニズムの解明

    國村和史、福井宣規

    第32回Kyoto T Cell Conference (KTCC)  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • DOCK2欠損によって惹起されるアレルギー性気道炎症の分子基盤

    松原圭佑、福井宣規

    第32回Kyoto T Cell Conference (KTCC)  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 薬剤アナフィラキシーに関わるMRGPRB2/X2受容体のシグナル経路の解明

    國村和史、福井宣規

    第51回日本免疫学会学術集会  2022.12 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • コレステロール硫酸は白血球におけるDOCK2-Rac経路の阻害を介して眼の免疫特権環境形成に寄与する

    國村和史、宇留野武人、杉浦悠毅、福井宣規

    第95回日本生化学会大会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 腫瘍によるコレステロール硫酸を介した免疫回避機構の発見

    國村和史、福井宣規

    第31回Kyoto T Cell Conference (KTCC)  2022.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • IL-31産生の分子基盤の解明とその創薬研究への展開 Invited

    福井宣規

    第95回日本薬理学会年会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • アトピー性皮膚炎におけるEPAS1誘導性IL-31産生を抑制する低分子化合物の開発 International conference

    國村和史、福井宣規

    第30回ホットスプリングハーバー国際シンポジウム  2022.1 

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    Event date: 2022.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • ヘルパーT細胞におけるIL-31の産生を阻害する低分子化合物の開発

    福井宣規

    環境医学研究所・順天堂かゆみ研究センター第7回学術シンポジウム  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • EPAS1によって誘導されるIL-31産生を選択的に阻害する低分子化合物の発見

    國村和史、福井宣規

    第50回日本免疫学会学術集会  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良   Country:Japan  

  • IL-31の産生制御機構および痒みの伝達機構:バイオロジーから創薬へ International conference

    國村和史、福井宣規

    第16回生命医科学研究所ネットワーク国際シンポジウム  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • IL-31の産生と痒み伝達の分子基盤:基礎生物学から創薬研究へ International conference

    福井宣規

    第30回国際痒みシンポジウム  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • アトピー性皮膚炎におけるEPAS1誘導性IL-31産生を抑制する低分子化合物の開発

    國村和史、福井宣規

    第70回日本アレルギー学会学術大会  2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • IL-31の産生と痒みの伝達の分子基盤 Invited

    福井宣規、坂田大治、中原剛士、古江増隆

    第50回日本皮膚免疫アレルギー学会総会学術大会  2020.12 

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    Event date: 2020.12 - 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高知   Country:Japan  

  • IL-31による痒み伝達の分子基盤 Invited

    福井宣規

    環境医学研究所・順天堂かゆみ研究センター第5回学術シンポジウム  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • DOCKファミリー分子によるアレルギー疾患制御の分子基盤 Invited

    福井宣規

    第5回総合アレルギー講習会  2018.12 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • Immune regulatory functions of DOCK family proteins in health and diseases Invited International conference

    Yoshinori Fukui

    The 9th Asian Congress of Pediatric Infectious Diseases, Symposium  2018.11 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Immune regulatory functions of DOCK family proteins in health and diseases Invited International conference

    Yoshinori Fukui

    Asian Society for Mitochondrial Research and Medicine  2018.11 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in helper T cells. International conference

    Yoshinori Fukui, Kazuhiko Yamamura

    The 18th Biennial Meeting of the European Society of Immunodeficiencies  2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Portugal  

  • 免疫アレルギー疾患とDOCKファミリー分子 Invited

    福井 宣規

    第55回日本小児アレルギー学会学術大会  2018.10 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岡山   Country:Japan  

  • DOCK2の機能を阻害する代謝産物の発見:その産生と生体機能 Invited

    福井 宣規

    第91回日本生化学会大会シンポジウム  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Immune regulatory function of DOCK8 in health and diseases Invited

    11th International Symposium of the Institute Network "Frontiers in Biomedical Sciences"  2017.1 

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    Event date: 2017.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • DOCK1 as a novel molecular target for controlling cancer invasion, metastasis and survival

    11th International Symposium of the Institute Network "Frontiers in Biomedical Sciences"  2017.1 

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    Event date: 2017.1

    Language:English  

    Country:Japan  

  • Rac活性化を標的とした新しい抗がん剤創出の試み Invited

    福井 宣規

    創薬等支援技術基盤プラットフォーム公開シンポジウム  2016.12 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Critical role of the DHR-1 domain in localization and function of DOCK8

    16th International Congress of Immunology  2016.8 

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    Event date: 2016.8

    Language:English  

    Country:Australia  

  • Identification of molecules critical for neutrophil extracellular trap

    16th International Congress of Immunology  2016.8 

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    Event date: 2016.8

    Language:English  

    Country:Australia  

  • Coordinate regulation of dendritic cell migration by the DOCK family of Rac guanine exchange factors

    16th International Congress of Immunology  2016.8 

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    Event date: 2016.8

    Language:English  

    Country:Australia  

  • B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity

    16th International Congress of Immunology  2016.8 

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    Event date: 2016.8

    Language:English  

    Country:Australia  

  • 生体防御システムにおけるDOCKファミリー分子の機能とその制御機構

    福井 宣規

    生体防御学会シンポジウム  2016.7 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 免疫システムにおけるDOCKファミリー分子の機能とその制御機構

    福井 宣規

    第68回日本細胞生物学会大会  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • DOCK1 as a novel molecular target for controlling cancer invasion and metastasis

    2015.11 

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    Event date: 2015.11

    Language:English  

    Country:Japan  

  • Critical role of DOCK8 in nucleokinesis during macrophage migration

    Akira Shiraishi, 福井 宣規

    2015.11 

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    Event date: 2015.11

    Language:English  

    Venue:札幌   Country:Japan  

  • B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity

    The 44rd Annual Meeting of The Japanese Society for Immunology  2015.11 

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    Event date: 2015.11

    Language:English  

    Country:Japan  

  • DOCK1 as a novel molecular target for controlling cancer invasion and metastasis

    2015.11 

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    Event date: 2015.11

    Language:English  

    Country:Japan  

  • Rac活性化機能を標的とした新規がん治療薬

    宇留野 武人, 福井 宣規

    P-DIRECTアカデミア創薬シーズ発表会  2015.8 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • マスト細胞の脱顆粒反応におけるDOCK5の役割とその制御機構 International conference

    福井 宣規

    第64回日本アレルギー学会学術大会  2015.5 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity International conference

    The 25th Kyoto T cell Conference (KTCC 2015)  2015.5 

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    Event date: 2015.5

    Language:English  

    Country:Japan  

  • Critical role of DOCK8 in the intestinal maintenance of homeostasis International conference

    The 25th Kyoto T cell Conference (KTCC 2015)  2015.5 

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    Event date: 2015.5

    Language:English  

    Country:Japan  

  • A novel mechanism controlling Aire protein expression in the thymus International conference

    The Fourth BIZAN Immunology Symposium  2015.1 

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    Event date: 2015.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Critical roles of DOCK family proteins in migration and activation of leukocytes International conference

    Keystone Symposium  2015.1 

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    Event date: 2015.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • The role of DOCK8 in migration and activation of effector CD4+ T cells during immune responses. International conference

    The 43rd Annual Meeting of The Japanese Society for Immunology  2014.12 

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    Event date: 2014.12

    Language:English  

    Country:Japan  

  • Identification of a novel molecule essential for Aire expression and self-tolerance International conference

    The 43rd Annual Meeting of The Japanese Society for Immunology  2014.12 

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    Event date: 2014.12

    Language:English  

    Country:Japan  

  • DOCK1 as a novel molecular target for controlling cancer invasion and metastasis International conference

    The 25th Annual Meeting of the Japanese Society for Gastroenterolgical Carcinogeniesis  2014.11 

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    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Critical roles of DOCK family proteins in migration and activation of leukocytes International conference

    The 24th Hot Spring Harbor International Symposium  2014.11 

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    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Critical role of DOCK8 in nucleokinesis during macrophage migration International conference

    The 24th Hot Spring Harbor International Symposium  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Japan  

  • B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity International conference

    The 24th Hot Spring Harbor International Symposium  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Japan  

  • Critical role of DOCK8 in the intestinal innate lymphoid cells International conference

    The 24th Hot Spring Harbor International Symposium  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Japan  

  • Identification of a novel molecule essential for Aire expression and self-tolerance International conference

    The 24th Hot Spring Harbor International Symposium  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Japan  

  • The role of DOCK8 in migration and activation of effector CD4+ T cells during immune responses International conference

    The 24th Hot Spring Harbor International Symposium  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Japan  

  • 胸腺上皮細胞の分化・形成に必要な核内酵素の同定とその機能解析 International conference

    Toyoshi Yanagihara, Fumiyuki Sanematsu, Mayuki Watanabe, Takahiro Tomino, Takehito Uruno, 福井 宣規

    2014.5 

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    Event date: 2014.5

    Language:Japanese  

    Venue:京都   Country:Japan  

  • Critical role of DOCK8 in dendritic cell trafficking during T cell immune responses. International conference

    International Symposium between Kyushu U. Post-Global COE and School of Biomedical Sciences, Monash U.  2014.2 

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    Event date: 2014.2

    Country:Australia  

  • DOCK1 as a key molecule for dorsal ruffle formation and cancer cell metastasis. International conference

    International Symposium between Kyushu U. Post-Global COE and School of Biomedical Sciences, Monash U.  2014.2 

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    Event date: 2014.2

    Country:Australia  

  • Identification of a molecule critical for degranulation of mast cells and anaphylactic reaction.

    Annual Meeting of The Japanese Society for Immunology 2013  2013.12 

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    Event date: 2013.12 - 2012.12

    Country:Japan  

  • Critical roles of DOCK2 and DOCK5 in neutrophil chemotaxis, ROS production, and NETs formation.

    Annual Meeting of The Japanese Society for Immunology 2013  2013.12 

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    Event date: 2013.12 - 2012.12

    Country:Japan  

  • Critical roles of DOCK2 and DOCK5 in neutrophil chemotaxis, ROS production, and NETs formation. International conference

    15th International Congress of Immunology  2013.8 

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    Event date: 2013.8 - 2012.8

    Presentation type:Oral presentation (general)  

    Country:Italy  

  • The Rac activator DOCK2 regulates natural killer cell-mediatd cytotoxicity through the lytic synapse formation. International conference

    15th International Congress of Immunology  2013.8 

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    Event date: 2013.8 - 2012.8

    Presentation type:Oral presentation (general)  

    Country:Italy  

  • Identification of a molecule critical for degranulation of mast cells and anaphylactic reaction International conference

    15th International Congress of Immunology  2013.8 

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    Event date: 2013.8 - 2012.8

    Presentation type:Oral presentation (general)  

    Country:Italy  

  • Identification of a molecule critical for degranulation of mast cells and anaphylactic reaction International conference

    15th International Congress of Immunology  2013.8 

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    Event date: 2013.8 - 2012.8

    Presentation type:Oral presentation (general)  

    Country:Italy  

  • B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity. International conference

    15th International Congress of Immunology  2013.8 

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    Event date: 2013.8 - 2012.8

    Presentation type:Oral presentation (general)  

    Country:Italy  

  • DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. International conference

    15th International Congress of Immunology  2013.8 

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    Event date: 2013.8 - 2012.8

    Presentation type:Oral presentation (general)  

    Country:Italy  

  • Critical role of DOCK8 in dendritic cell trafficking during T cell immune responses. International conference

    15th International Congress of Immunology  2013.8 

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    Event date: 2013.8 - 2012.8

    Presentation type:Oral presentation (general)  

    Country:Italy  

  • Selective requirement of DOCK8 for dendritic cell migration in three-dimensional environments. International conference

    The 8th International Symposium of the Institute Network  2013.6 

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    Event date: 2013.6 - 2012.6

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Critical role of DOCK8 in dendritic cell trafficking during T cell immune responses International conference

    Akira Shiraishi, Yoshihiko Tanaka, Yosuke Harada

    Post-GCOE Symposium and Retreat in Singapore  2013.3 

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    Event date: 2013.3 - 2012.3

    Presentation type:Oral presentation (general)  

    Country:Other  

  • DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune response. International conference

    Post-GCOE Symposium and Retreat in Singapore  2013.3 

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    Event date: 2013.3 - 2012.3

    Presentation type:Oral presentation (general)  

    Country:Other  

  • Identification of a molecule critical for degranulation of mast cells and anaphylactic reaction International conference

    Post-GCOE Symposium and Retreat in Singapore  2013.3 

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    Event date: 2013.3 - 2012.3

    Presentation type:Oral presentation (general)  

    Country:Other  

  • Critical roles of DOCK2 and DOCK5 in neutrophil chemotaxis, ROS production, and NETs formation. International conference

    Post-GCOE Symposium and Retreat in Singapore  2013.3 

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    Event date: 2013.3 - 2012.3

    Presentation type:Oral presentation (general)  

    Country:Other  

  • B cell-intrinsic role of DOCK2 in T cell-dependent humoral immunity. International conference

    Post-GCOE Symposium and Retreat in Singapore  2013.3 

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    Event date: 2013.3 - 2012.3

    Presentation type:Oral presentation (general)  

    Country:Other  

  • Dock8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.

    The 23rd CDB Meeting Building multicellular systems from Cellular Cross-Talk  2013.2 

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    Event date: 2013.2 - 2012.2

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • A novel strategy for treatment of immune-related disorders by using cytoskeleton regulating signals as targets.

    JST-CREST International Symposium  2013.2 

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    Event date: 2013.2 - 2012.2

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune response.

    JST-CREST International Symposium  2013.2 

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    Event date: 2013.2 - 2012.2

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • Role of DOCK1 and its regulation during dorsal ruffle formation.

    2012.12 

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    Event date: 2012.12

    Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • 樹状細胞の3次元での動きを制御するCdc42活性化分子DOCK8

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Venue:福岡   Country:Japan  

  • DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.

    2012.7 

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    Event date: 2012.12

    Country:Japan  

  • ヒト免疫不全症の責任分子DOCK8の生理的機能とその制御

    田中 芳彦, 原田 洋輔, 福井 宣規

    2012.7 

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    Event date: 2012.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • Identification of a signaling molecule critical for dendritic cell migration in three-dimensional environments. International conference

    Harada Y, Tanaka Y, Terasawa M, Fukui Y

    The 21st Hot Spring Harbor Symposium jointly with 9th Global COE International Symposium and 8th Young Investigators Forum  2012.1 

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    Event date: 2012.1

    Country:Japan  

  • Structural basis of functional complex formation between DOCK2 and ELMO1. International conference

    Watanabe M, Nishikimi A, Uruno T, Kukimoto-Niino M, Yokoyama S, Fukui Y

    The 10th Global COE International Symposium and 7th Young Investigation Forum  2011.12 

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    Event date: 2011.12

    Country:Singapore  

  • Regulation of NK cell-mediated cytotoxicity by the atypical Rac activators International conference

    Sakai Y, Tanaka Y, Fukui Y

    The 10th Global COE International Symposium and 7th Young Investigation Forum  2011.12 

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    Event date: 2011.12

    Country:Singapore  

  • Functional significance of DOCK2 dimerization in lymphocyte migration International conference

    Yanagihara T, Terasawa M, Uruno T, Mori S, Nishikimi A, Fukui Y

    The 10th Global COE International Symposium and 7th Young Investigation Forum  2011.12 

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    Event date: 2011.12

    Country:Singapore  

  • Identification of a signaling molecule critical for dendritic cell migration in three-dimensional environments International conference

    Harada Y, Tanaka Y, Terasawa M, Fukui Y

    The 10th Global COE International Symposium and 7th Young Investigation Forum  2011.12 

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    Event date: 2011.12

    Country:Singapore  

  • Regulation of FcεRI-mediated mast cell degranulation by the atypical GEF International conference

    2011.12 

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    Event date: 2011.12

    Venue:Singapore   Country:Singapore  

  • リンパ球遊走におけるDOCK2ダイマー形成の機能的意義

    寺澤公男,福井宣規

    第40回日本免疫学会学術集会  2011.11 

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    Event date: 2011.11

    Venue:千葉   Country:Japan  

  • 免疫特異的なRac活性化因子DOCK2を標的とした免疫抑制剤の開発

    錦見昭彦、田中芳彦、福井宣規

    第40回日本免疫学会学術集会  2011.11 

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    Event date: 2011.11

    Venue:千葉   Country:Japan  

  • リンパ球遊走におけるDOCK2ダイマー形成の機能的意義

    寺澤公男,宇留野武人,森沙也子,福井宣規

    第21回Kyoto T Cell Conference  2011.6 

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    Event date: 2011.6

    Venue:京都   Country:Japan  

  • Control of cardiovascular development by the atypical Rac activator DOCK180 International conference

    Sanenatsu F, Fukui Y

    The 6th International symposium of Institute Network  2011.6 

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    Event date: 2011.6

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • The atyipcal Rac activator DOCK5 regulates osteoclast function for bone homeostasis. International conference

    Sakai Y, Tanaka Y, Fukui Y

    7th Global COE International Symposium and 6th Young Investigators Forum  2011.2 

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    Event date: 2011.2

    Country:Singapore  

  • DOCK180 is a Rac activator that regulates cardiovascular development by acting downstrearm of CXCR4. International conference

    Harada Y, Sanematsu F, Fukui Y

    7th Global COE International Symposium and 6th Young Investigators Forum  2011.2 

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    Event date: 2011.2

    Country:Singapore  

  • Critical role of DOCK2 in type I IFN induction in plasmacytoid dendritic cells. International conference

    Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Hoshino K, Kaisho T, Yoshikai Y, Fukui Y

    14th International Congress of Immunology  2010.8 

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    Event date: 2010.8

    Country:Japan  

  • Critical role of DOCK2 in type I IFN induction in plasmacytoid dendritic cells. International conference

    GotohK, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Higashi S, Uruno T, Yoshikai Y, Fukui Y

    The 5th International Symposium of Institute Network, P-2  2010.6 

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    Event date: 2010.6

    Country:Japan  

  • TLRを介した形質細胞様樹状細胞活性化におけるDOCK2の役割

    後藤和人、田中芳彦、福井宣規

    Kyoto T Cell Conference 第20回学術集会  2010.6 

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    Event date: 2010.6

    Venue:京都大学   Country:Japan  

  • Critical role of DOCK2 in type I IFN induction in plasmacytoid dendritic cells. International conference

    Gotoh K, Fukui Y

    The 5th Global COE International Symposium  2010.2 

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    Event date: 2010.2

    Country:Singapore  

  • 形質細胞様樹状細胞による1型インターフェロン産生におけるDOCK2の役割

    後藤和人、田中芳彦、錦見昭彦、吉開泰信、福井宣規

    第39回日本免疫学会総会・学術集会  2009.12 

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    Event date: 2009.12

    Venue:大阪   Country:Japan  

  • Molecular mechanism controlling intracellular DOCK2 dynamics during neutrophil chemotaxis International conference

    Nishikimi A, Fukui Y

    The 4th Global COE International Symposium2009 joint with the 19th Hot Spring Harbor Symposium  2009.11 

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    Event date: 2009.11

    Country:Japan  

  • 免疫応答を司る免疫系受容体のメンブレントラフィックを介した時間的空間的制御 Invited

    田中芳彦、福井宣規

    第82回日本生化学会大会  2009.10 

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    Event date: 2009.10

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • Molecular mechanism controlling intracellular DOCK2 dynamics during neutrophil chemotaxis International conference

    Nishikimi A, Fukui Y

    The 5th International Workshop of Kyoto T Cell Conference  2009.6 

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    Event date: 2009.6

    Country:Japan  

  • リン脂質を介したRac活性化分子DOCK2の時空間的制御 Invited

    錦見昭彦、福井宣規

    第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会  2008.12 

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    Event date: 2008.12

    Venue:神戸   Country:Japan  

  • アレルギー反応を制御するDOCK2-Racシグナルを介した新しい分子メカニズムの解明

    田中芳彦、錦見昭彦、後藤和人、稲吉あゆみ、福井宣規

    第38回日本免疫学会総会  2008.12 

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    Event date: 2008.12

    Venue:京都   Country:Japan  

  • 形質細胞様樹状細胞の遊走・活性化におけるCDM family 分子DOCK2の役割

    後藤和人、田中芳彦、錦見昭彦、前田直良、石川天洋、稲吉あゆみ、吉開泰信、福井宣規

    第38回日本免疫学会総会  2008.12 

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    Event date: 2008.12

    Venue:京都   Country:Japan  

  • 好中球におけるリン脂質を介したRac活性分子DOCK2の時空間制御

    錦見昭彦、田中芳彦、福井宣規

    第38回日本免疫学会総会  2008.12 

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    Event date: 2008.12

    Venue:京都   Country:Japan  

  • Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

    Gotoh K, Tanaka Y, Nishikimi A, Fukui Y

    2008.9 

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    Event date: 2008.9

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 造血系細胞特異的に発現するCDMファミリー遺伝子の単離とその機能解析

    福井 宣規、讃井 彰一、大野 隆真、笹月 健彦

    日本免疫学会  2000.1 

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    Venue:仙台市  

  • 自然発症末梢神経特異的自己免疫疾患マウスモデルの樹立とその発症におけるT細胞レパートリー選択の関与

    大野 隆真、福井 宣規、讃井 彰一、笹月 健彦

    日本免疫学会  2000.1 

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    Venue:仙台市  

  • 高親和性可溶性TCRの樹立とその未知抗原ペプチド同定への応用

    讃井 彰一、福井 宣規、大野 隆真、笹月 健彦

    日本免疫学会  2000.1 

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    Venue:仙台市  

  • 単一MHC/ペプチド複合体上で分化したT細胞が末梢で自己およびアロMHC分子の拘束下で認識する抗原ペプチドの同定

    大野 隆真、福井 宣規、讃井 彰一、笹月 健彦

    日本免疫学会  2001.1 

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    Venue:大阪  

  • リンパ球の運動性を制御する分子の同定

    讃井 彰一、福井 宣規、橋本 修、白井 修一、笹月 健彦

    日本免疫学会  2001.1 

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    Venue:大阪  

  • How peptide/MHC complex phapes the T cell repertoire in the thymus? Invited International conference

    Sasazuki, T. and Fukui, Y

    2001.1 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Thailand  

  • HLA and immune regulation Invited International conference

    Sasazuki T, Fukui Y

    International Congress of Histocompatibility and Immunogenetics  2002.1 

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    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • Development of soluble MHC class II cobalently linked with an immunodominant cholera toxin epitope for thedetection of antigen-specific mucosal Th cells

    Igarashi O, Kim JK, Fukui Y, Yuki Y, Kiyono H

    2002.1 

  • Tリンパ球の細胞高次機能制御におけるCDMファミリー分子DOCK2の役割

    讃井 彰一、福井 宣規、笹月 健彦

    日本免疫学会  2002.1 

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    Venue:東京  

  • DOCK2 is critical for alloreactive T cell homing, activation, and intragraft infiltration during transplant regection. International conference

    Fan Pan, Laurie M, Erickson, Mei-Shiang Jang, Terukazu Sanui, Yuya Kunisaki, Takehiko Sasazuki, Masakazu Kobayashi, Kouichi Tamura,Yoshinori Fukui, Hongsi Jiang

    World Transplantation Congress  2006.7 

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    Presentation type:Oral presentation (general)  

    Country:United States  

  • DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.

    Akihiko Nishikimi, Yuya Kunisaki, Yoshihiko Tanaka, Ryosuke Takii, Ken-ichi Watanabe, Takehiko Sasazuki, Yoshinori Fukui

    2006.12 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 細胞骨格制御分子DOCK2は形質細胞様樹状細胞の遊走を制御する

    後藤和人、田中芳彦、錦見昭彦、國崎祐哉、福井宣規

    第36回日本免疫学会総会  2006.12 

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    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • アレルギー性免疫応答制御における細胞骨格制御分子DOCK2の役割

    田中芳彦、錦見昭彦、國崎祐哉、後藤和人、稲吉あゆみ、福井宣規

    第36回日本免疫学会総会  2006.12 

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    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • DOCK2 links TCR signals to IL-4 receptor downregulation to control lineage commitment of CD4+ T cells International conference

    Tanaka Y and Fukui Y

    THe Awaji International Forum on Infection and Immunity  2007.9 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • B細胞の分化・増殖におけるDOCK2の機能

    川口真喜子、錦見昭彦、田中芳彦、福井宣規

    第37回日本免疫学会総会  2007.11 

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    Venue:東京   Country:Japan  

  • IL-4受容体のメンブレントラフィックを介したDOCK2-RacシグナルによるCD4+T細胞lineage commitment制御機構の解明

    田中芳彦、錦見昭彦、後藤和人、川口真喜子、稲吉あゆみ、福井宣規

    第37回日本免疫学会総会  2007.11 

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    Venue:東京   Country:Japan  

  • DOCK2-Rac signaling pathway controls lineage commitment of CD4+ T cells via intracellular trafficking of the interleukin 4 receptor-alpha subunit International conference

    Tanaka Y and Fukui Y

    International Symposium on Membrane Traffic  2007.11 

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    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • How TCR-MHC-peptide interaction determines the fate of T cells Invited International conference

    Sasazuki T. and Fukui, Y

    US-Japan and German-Japan Joint Immunology Meeting  2000.1 

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    Presentation type:Symposium, workshop panel (public)  

  • T cell repertoire selection snd immune regulation by a single peptide-MHC complex Invited International conference

    Sasazuki, T. and Fukui, Y

    1998.1 

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    Presentation type:Symposium, workshop panel (public)  

  • TCR-MHC-peptide interaction in T cell repertoire selection Invited

    Sasazuki, T. and Fukui, Y

    1998.1 

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    Presentation type:Symposium, workshop panel (public)  

  • 可溶性四量体MHCクラス?/ペプチド複合体を用いた抗原特異的CD4陽性T細胞の同定

    具嶋 敏文、福井 宣規、笹月 健彦

    日本免疫学会  1998.1 

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    Venue:神戸  

  • 単一MHC/ペプチド複合体を発現したトランスジェニック−ノックアウトマウスにおける臓器特異的自己免疫病変

    福井 宣規、橋本 修、大野 隆真、笹月 健彦

    日本免疫学会  1998.1 

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    Venue:神戸  

  • T細胞レパートリー形成における自己抗原ペプチドの関与

    福井 宣規、橋本 修、笹月 健彦

    1998.1 

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    Venue:京都  

  • Diversity' versus 'specificity' of T cell repertoire selected by a single peptide-MHC complex Invited International conference

    Sasazuki, T. and Fukui, Y

    1999.1 

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    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 胸腺でのT細胞レパートリー形成が末梢の免疫応答に及ぼす質的影響

    大野 隆真、福井 宣規、讃井 彰一、広川 勝、笹月 健彦

    日本免疫学会  1999.1 

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    Venue:京都市  

  • 単一MHCクラスII/ペプチド複合体によって形成されるT細胞レパートリーの機能的多様性の解析

    西方 宏昭、上川路 伸博、福井 宣規、笹月 健彦

    日本免疫学会  1999.1 

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    Venue:京都市  

  • 選択に関わる抗原ペプチドの構造によって影響されるT細胞レパートリーの多様性と特異性

    福井 宣規、大野 隆真、讃井 彰一、広川 勝、笹月 健彦

    日本免疫学会  1999.1 

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    Venue:京都市  

  • 単一MHCクラスII/ペプチド複合体を発現したトランスジェニックノックアウトマウスにおける臓器特異的自己免疫病

    福井 宣規、橋本 修、大野 隆真、笹月 健彦

    日本人類遺伝学会  1999.1 

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    Venue:仙台市  

  • T細胞レパートリー選択と自己免疫疾患 Invited

    福井 宣規

    日本臨床免疫学会  2000.1 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:宇都宮市  

  • Contribution of MHC and non-MHC loci to the susceptibility to organ-specific autoimmune disease. Invited International conference

    Sasazuki T. and Fukui, Y

    International Congress on Allergology and Clinical Immunology  2000.1 

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    Presentation type:Oral presentation (general)  

    Country:Australia  

  • MHCによる免疫系のフレームワーク決定機構 Invited

    福井 宣規、笹月 健彦

    日本人類遺伝学会  2000.1 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡  

  • Diversity versus specificity' of T cell repertoire shaped by a single peptide-MHC complex Invited

    Sasazuki, T. and Fukui, Y

    2000.1 

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    Presentation type:Symposium, workshop panel (public)  

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MISC

  • The molecular basis for IL-31 production and IL-31-mediated itch transmission : from biology to durg development. Reviewed

    Kunimura K, Fukui Y

    Int. Immunology   2021.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • DOCK-family proteins:key players in immune surveillance mechanisms. Reviewed

    Kunimura K, Uruno T, Fukui Y

    Int. Immunology   2020.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis. Reviewed

    Furue M, Yamamura K, Kido-Nakahara M, Nakahara T, Fukui Y

    Allergy   2018.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 薬剤性アナフィラキシーに関わるMRGPRX2/B2受容体を介したマスト細胞の脱顆粒制御機構

    國村和史、福井宣規

    月刊 臨床免疫・アレルギー科(科学評論社)   2023.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • アトピー性皮膚炎におけるIL-31の産生制御機構

    國村和史、福井宣規

    月刊 皮膚科 (科学評論社)   2023.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 創薬標的としてのIL-31の分子基盤:DOCK8と転写因子EPAS1

    國村和史、福井宣規

    臨床免疫・アレルギー科 (科学評論社)   2022.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 免疫抑制剤開発の新しい分子標的としてのDOCK2

    宇留野 武人, 福井 宣規

    実験医学増刊   2014.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Immune regulatory functions of DOCK family proteins in health and disease. Reviewed

    Akihiko Nishikimi, Mutsuko Kukimoto-Niino, Shigeyuki Yokoyama, Yoshinori Fukui

    Exp. Cell. Res.   2013.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 新たな免疫抑制剤開発標的としてのRac活性化因子DOCK2

    福井 宣規

    細胞工学   2013.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 心血管形成におけるDOCK180の機能とその制御機構

    實松史幸、福井宣規

    感染・炎症・免疫   2013.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 獲得免疫システムを支える白血球動態の制御機構

    福井宣規

    生化学   2012.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 自然免疫システムにおけるDOCK2の機能とその制御

    田中芳彦、福井宣規

    細胞工学   2011.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 免疫系細胞高次機能を司るCDMファミリー分子DOCK2

    福井宣規

    感染・炎症・免疫   2009.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 2つのリン脂質を介した好中球遊走におけるDOCK2細胞内動態の連続的制御

    錦見昭彦、福井宣規

    細胞工学   2009.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 好中球遊走を制御するRac活性化分子 DOCK2

    福井宣規

    実験医学   2006.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • リンパ球の運動性を制御する分子DOCK2

    福井宣規

    医学のあゆみ   2005.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 免疫シナプス形成を制御するCDMファミリー分子DOCK2

    福井宣規

    Molecular Medicine 増刊「免疫2005」   2004.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • CDMファミリー分子DOCK2による免疫シナプス形成の制御

    讃井彰一、福井宣規

    細胞工学   2003.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 免疫応答におけるリンパ球の動態-HCH欠損マウスの情報-

    讃井彰一、福井宣規

    感染・炎症・免疫   2003.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • CDMファミリー分子DOCK2によるリンパ球遊走の制御

    福井宣規

    Molecular Medicine 増刊「免疫2003」   2002.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • リンパ球遊走、ホーミングの制御機構

    福井宣規

    医学のあゆみ増刊「免疫疾患−state of arts」   2002.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • リンパ球遊走に不可欠なCDMファミリー分子DOCK2

    福井宣規

    蛋白質核酸酵素増刊「免疫研究の最前線:高次複雑免疫システムの包括的理解をめざして」   2002.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • CDMファミリー分子DOCK2によるリンパ球遊走の制御

    福井宣規

    細胞工学   2001.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • リンパ球遊走に不可欠なCDMファミリー分子DOCK2

    福井宣規

    実験医学   2001.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胸腺T細胞の正と負の選択

    福井宣規

    遺伝子医学   1999.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胸腺内T細胞のセレクション

    福井宣規

    血液・免疫・腫瘍BIC Forum別冊   1999.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 胸腺内T細胞の正の選択におけるTCR-MHC-ペプチド相互作用

    福井宣規、笹月健彦

    Molecular Medicine 増刊「免疫1998-99」   1998.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • CDMファミリー分子DOCK2によるリンパ球遊走の制御

    讃井彰一、福井宣規、笹月健彦

    1900

     More details

    Language:Japanese  

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Industrial property rights

Patent   Number of applications: 3   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本免疫学会

  • Kyoto T cell Conference

Committee Memberships

  • Councilor   Domestic

    2006.10 - Present   

  • Kyoto T cell Conference   Steering committee member   Domestic

    2003.4 - Present   

Academic Activities

  • International Immunology International contribution

    2017.1 - 2020.1

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    Type:Academic society, research group, etc. 

  • 戦略的創造研究推進事業(さきがけ)領域アドバイザー

    Role(s): Review, evaluation

    科学技術振興機構  2010.11 - 2012.11

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    免疫学会  ( 京都 ) 2008.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本分子生物学会フォーラム  ( 名古屋国際会議場 ) 2006.12 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本免疫学会  ( 福岡国際会議場 ) 2003.12 - Present

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    Type:Competition, symposium, etc. 

Other

  • Nature/Alliance for Cell Signaling (AfCS)では、生体機能に重要と考えられるシグナル伝達分子を対象に、Molecular Pageと呼ばれるデータベースの構築を行っている。当該研究者は、Nature Publishing Groupeからの依頼を受け、DOCK2のMolecular Pageを担当している。

    2006.1

Research Projects

  • 免疫細胞特異的Rac活性化因子Dock2によるアレルギー性気道炎症制御の分子基盤

    Grant number:24K02263  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 革新的先端研究開発支援事業(CREST)

    2019.10 - 2025.3

    九州大学生体防御医学研究所 

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    Authorship:Principal investigator 

  • 硫酸基転移酵素SULT2B1bの発現制御機構と生体機能の統合的理解

    Grant number:19H00983  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • リジン水酸化酵素Jmjd6を介したAire発現制御の分子基盤とその進化学的考察

    Grant number:16H02497  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • Leading Advanced Medical Innovation (LEAP)

    2015.10 - 2020.3

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    Authorship:Principal investigator 

  • 次世代がん研究プロジェクト

    2011.2 - 2014.3

    文部科学省 

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    Authorship:Principal investigator 

  • 戦略的創造研究推進事業(CREST)

    2008.10 - 2013.3

    科学技術振興機構 

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    Authorship:Principal investigator 

    免疫応答におけるCDMファミリー分子群の機能、構造、シグナル伝達系を包括的に解析し、その理解に立脚して免疫難病の新しい治療法を開発する。

  • グローバルCOEプロジェクト

    2007.9 - 2012.3

    文部科学省 

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    Authorship:Coinvestigator(s) 

    個体恒常性を担う細胞運命の決定機構を解明する

  • ターゲットタンパクプロジェクト

    2007.7 - 2012.3

    文部科学省 

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    Authorship:Principal investigator 

    DOCK2を標的とした創薬研究

  • ゲノムネットワークプロジェクト

    2006.7

    文部科学省 

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    Authorship:Principal investigator 

    受容体刺激からRac活性化に至るDOCK2シグナルネットワークを明らかにする。

  • 戦略的創造研究推進事業(PRESTO)

    2003.11 - 2007.3

    科学技術振興機構 

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    Authorship:Principal investigator 

    受容体刺激から細胞骨格再構築に至るシグナル伝達を解明し、その機能を個体レベルで明らかにすると共に、その成果に立脚して自己免疫疾患、移植片拒絶、感染症など現代医学が抱える難治性疾患の新しい治療法、予防法の開発を目指す。

  • 戦略的基礎研究推進事業(CREST)

    1997.10 - 2002.9

    科学技術振興事業団 

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    Authorship:Coinvestigator(s) 

    T細胞レパートリ形成及び免疫制御機構の分子機構を、TCR-MHC/ペプチド相互作用という観点から解明する。

▼display all

Class subject

  • 口腔免疫学

    2019.10 - 2020.3   Second semester

  • 遺伝学

    2019.10 - 2020.3   Second semester

  • 免疫学

    2019.4 - 2019.9   First semester

  • 口腔免疫学

    2018.10 - 2019.3   Second semester

  • 遺伝学

    2018.10 - 2019.3   Second semester

  • 免疫学

    2018.4 - 2018.9   First semester

  • 口腔免疫学

    2017.10 - 2018.3   Second semester

  • 遺伝学

    2017.10 - 2018.3   Second semester

  • 免疫学

    2017.4 - 2017.9   First semester

  • 口腔免疫学

    2016.10 - 2017.3   Second semester

  • 遺伝学

    2016.10 - 2017.3   Second semester

  • 免疫学

    2016.4 - 2016.9   First semester

  • 口腔免疫学

    2015.10 - 2016.3   Second semester

  • 遺伝学

    2015.10 - 2016.3   Second semester

  • 免疫学

    2015.4 - 2015.9   First semester

  • 口腔免疫学

    2014.10 - 2015.3   Second semester

  • 遺伝学

    2014.10 - 2015.3   Second semester

  • 免疫学

    2014.4 - 2014.9   First semester

  • 口腔免疫学

    2013.10 - 2014.3   Second semester

  • 遺伝学

    2013.10 - 2014.3   Second semester

  • 免疫学

    2013.4 - 2013.9   First semester

  • 生命科学概論1

    2012.10 - 2013.3   Second semester

  • 口腔予防医学

    2012.10 - 2013.3   Second semester

  • 遺伝学

    2012.10 - 2013.3   Second semester

  • 免疫学

    2012.4 - 2012.9   First semester

  • 微生物学・免疫学研究法

    2012.4 - 2012.9   First semester

  • 免疫学

    2011.4 - 2011.9   First semester

  • 生命科学概論1

    2010.10 - 2011.3   Second semester

  • 口腔免疫学

    2010.10 - 2011.3   Second semester

  • 遺伝学

    2010.10 - 2011.3   Second semester

  • 免疫学

    2010.4 - 2010.9   First semester

  • 生命科学概論

    2009.10 - 2010.3   Second semester

  • 遺伝学

    2009.10 - 2010.3   Second semester

  • 分子免疫学

    2009.4 - 2009.9   First semester

  • 免疫学

    2009.4 - 2009.9   First semester

  • 口腔免疫学

    2009.4 - 2009.9   First semester

  • 生命科学概論 1

    2008.10 - 2009.3   Second semester

  • 遺伝学

    2008.4 - 2009.3   Full year

  • 口腔免疫学

    2008.4 - 2008.9   First semester

  • 分子免疫学

    2008.4 - 2008.9   First semester

  • 免疫学

    2007.4 - 2008.3   Full year

  • 微生物学・免疫学研究法

    2007.4 - 2007.9   First semester

  • 口腔免疫学

    2007.4 - 2007.9   First semester

  • 免疫細胞解析学

    2006.10 - 2007.3   Second semester

  • 免疫学

    2006.4 - 2007.3   Full year

  • 遺伝学

    2006.4 - 2007.3   Full year

  • 微生物学・免疫学研究法

    2006.4 - 2006.9   First semester

  • 臨床微生物学特論

    2005.10 - 2006.3   Second semester

  • 遺伝学

    2005.4 - 2006.3   Full year

  • 免疫学

    2005.4 - 2006.3   Full year

  • 微生物学・免疫学研究法

    2005.4 - 2005.9   First semester

  • 臨床微生物学特論

    2004.10 - 2005.3   Second semester

  • 遺伝学

    2004.4 - 2005.3   Full year

  • 免疫学

    2004.4 - 2005.3   Full year

  • 微生物学・免疫学研究法

    2004.4 - 2004.9   First semester

  • 医学総合講義 老年病学

    2003.10 - 2004.3   Second semester

  • 免疫学

    2003.4 - 2004.3   Full year

  • 遺伝学

    2003.4 - 2004.3   Full year

  • 微生物学・免疫学研究法

    2003.4 - 2003.9   First semester

  • 臨床微生物学特論

    2003.4 - 2003.9   First semester

  • 免疫学

    2002.4 - 2003.3   Full year

  • 遺伝学

    2002.4 - 2003.3   Full year

  • 微生物学・免疫学研究法

    2002.4 - 2002.9   First semester

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FD Participation

  • 2009.12   Role:Participation   Title:医学部ファカルティディベロップメント

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2008.12   Role:Participation   Title:医学部ファカルティディベロップメント

    Organizer:[Undergraduate school/graduate school/graduate faculty]

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2022  順天堂大学環境医学研究所  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2013  スイスベルン大学  Classification:Part-time lecturer  Domestic/International Classification:Overseas 

  • 2012  カナダモントリオール/IRCM  Classification:Part-time lecturer  Domestic/International Classification:Overseas 

  • 2010  筑波大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2009  佐賀大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2006  秋田大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:9/15

  • 2006  名古屋大学理学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:11/9-11/10

  • 2005  筑波大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:9/30

  • 2005  宮崎大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:5/20

  • 2003  久留米大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:5/27

  • 2002  久留米大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:5/28

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Media Coverage

  • アトピー性皮膚炎の痒み物質の産生機構 TV or radio program

    NHKなど多数のmedia  2017.1

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    アトピー性皮膚炎の痒み物質の産生機構

  • 研究成果の紹介 TV or radio program

    2012.4

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    西日本新聞  2012.4

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    日刊工業新聞  2012.4

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    毎日新聞  2012.4

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    読売新聞  2012.4

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    日本経済新聞  2012.4

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    朝日新聞  2012.4

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    化学工業日報  2009.3

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    研究成果の紹介

  • 研究成果の紹介 Newspaper, magazine

    日経産業新聞  2009.3

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    研究成果の紹介

  • 研究論文の紹介 TV or radio program

    2007.9

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    毎日新聞  2007.9

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    日本経済新聞  2007.9

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    西日本新聞  2007.9

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    朝日新聞  2007.9

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    研究論文の紹介

  • 研究論文の紹介 TV or radio program

    2007.9

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    日本経済新聞  2001.1

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    日刊工業新聞  2001.1

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    日本工業新聞  2001.1

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    日経産業新聞  2001.1

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    研究論文の紹介

  • 研究論文の紹介 Newspaper, magazine

    西日本新聞  2001.1

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    研究論文の紹介

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Acceptance of Foreign Researchers, etc.

  • China Aguricultural University

    Acceptance period: 2006.10 - Present   (Period):1 month or more

    Nationality:China

    Business entity:Ministry of education

Travel Abroad

  • 1993.4 - 1995.3

    Staying countory name 1:United States   Staying institution name 1:スタンフォード大学/ハワードヒューズ医学研究所