TANAKA SHINYA
Organization
Medical Institute of Bioregulation Department of Immunobiology and Neuroscience Associate Professor
Graduate School of Medical Sciences Department of Medicine（Joint Appointment）
Graduate School of Medical Sciences Department of Medical Sciences（Joint Appointment）
Title
Associate Professor
External link
Degree
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学士 (理学)
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修士 (理学)
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Ph.D.
Research Interests・Research Keywords
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Research theme：Visualization and analysis of cell-cell interaction
Keyword：Cell-cell interaction
Research period： 2023.4 - 2023.6
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Research theme：Autoreactive T cell-mediated immune regulation
Keyword：Autoreactive T cells
Research period： 2022.4 - 2022.5
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Research theme：B cell-mediated regulation of inflammation
Keyword：Immunological tolerance, inflammation, regulatory B cells
Research period： 2018.5
Papers
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Humoral responses are enhanced by facilitating B cell viability by Fcrl5 overexpression in B cells. Reviewed International journal
Ono, C., Kochi, Y., Baba, Y., Tanaka, S.
International Immunology 2024.5
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Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease Invited Reviewed International journal
Chisato Ono, Shinya Tanaka, Keiko Myouzen,Takeshi Iwasaki, Mahoko Ueda, Yoshinao Oda,Kazuhiko Yamamoto, Yuta Kochi and Yoshihiro Baba
Frontiers in Immunology 2023.9
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Quiescent B cells acquire sensitivity to cell cycle arresting agents by B cell receptor stimulation Reviewed International journal
Hosokawa, T., Tanaka, S., Mori, T., Baba, Y., and Katayama, Y.
Biological and Pharmaceutical Bulletin 2022.5
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Silencing and activating anergic B cells. Invited Reviewed International journal
Tanaka, S., Ise, W., Baba, Y. & Kurosaki, T.
Immunological Reviews 2021.12
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The Role of TET Proteins in B Cell Biology Reviewed International journal
Shinya Tanaka, Wataru Ise, Yoshihiro Baba and Tomohiro Kurosaki
Journal of Immunological Science 2021.2
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Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity Reviewed International journal
Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A. Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba and Tomohiro Kurosaki
Nature Immunology 2020.8
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Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF4 Reviewed International journal
Kentaro Fujii, Shinya Tanaka, Takanori Hasegawa, Masashi Narazaki, Atsushi Kumanogoh, Haruhiko Koseki, Tomohiro Kurosaki, Wataru Ise
International immunology 2020.6
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Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3 Reviewed International journal
Tanaka K, Martinez GJ, Yan X, Long W, Ichiyama K, Chi X, Kim BS, Reynolds JM, Chung Y, Tanaka S, Liao L, Nakanishi Y, Yoshimura A, Zheng P, Wang X, Tian Q, Xu J, O'Malley BW, Dong C
Cell reports 2018.5
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Trim33 mediates the proinflammatory function of Th17 cells.
Tanaka, S., Jiang, Y., Martinez, G.J., Tanaka, K., Yan, X., Kurosaki, T., Kaartinen, V., Feng, X.H., Tian, Q., Wang, X., and Dong, C.
Journal of experimental medicine 1900
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The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
Ichiyama, K., T. Chen, X. Wang, X. Yan, B.S. Kim, S. Tanaka, D. Ndiaye-Lobry, Y. Deng, Y. Zou, P. Zheng, Q. Tian, I. Aifantis, L. Wei, and C. Dong.
1900
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Fibrinogen-cleavage products and TLR4 promote the generation of programmed cell death 1 ligand 2(PD-L2)+ dendritic cells in allergic asthma.
Cho, M., J.E. Lee, H. Lim, H.W. Shin, R. Khalmuratova, G. Choi, H.S. Kim, W.S. Choi, Y.J. Park, I. Shim, B.S. Kim, C.Y. Kang, J.O. Kim, S. Tanaka, M. Kubo, and Y. Chung.
Journal of Allergy and Clinical Immunology 1900
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Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3.
Tanaka, K., Martinez, G.J., Yan, X., Long, W., Ichiyama, K., Chi, X., Kim, B.S., Reynolds, J.M., Chung, Y., Tanaka, S., et al.
Cell reports 1900
Presentations
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Role of Ten-eleven translocation (Tet) in B cell self-toleranc
Shinya Tanaka, Wataru Ise, Tomohiro Kurosaki, Yoshihiro Baba
2021.12
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Role of Ten-eleven translocation (Tet) in B cell self-tolerance Invited
Shinya Tanaka
FIMSA 2021 2021.10
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Role of Ten-eleven translocation (Tet) in B cell self tolerance Invited International conference
Shinya Tanaka
The 15th International Symposium of the Institute Network for Biomedical Sciences 2020.11
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Ten-eleven translocation (Tet) in B cells prevent autoimmunity
Shinya Tanaka
The 48th Annual Meeting of the Japanese Society for Immunology 2019.12
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Ten-eleven translocation (Tet) demethylases mediate peripheral B cell tolerance. Invited International conference
Shinya Tanaka
The 47th Annual Meeting of the Japanese Society for Immunology 2018.12
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B cell-mediated inflammation by epigenetic regulators Invited International conference
Shinya Tanaka
Fall international convention of the pharmaceutical society of Korea 2018.10
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Ten-eleven translocation (Tet) demethylases mediate peripheral B cell tolerance Invited International conference
Shinya Tanaka
Seminar at Seoul National University 2018.10
MISC
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自己免疫疾患におけるメモリー様B細胞制御
田中伸弥・黒崎知博
実験医学増刊 自己免疫疾患 層別化する新時代へ 2022.9
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エピゲノム制御因子Ten-eleven translocation（Tet）分子によるB細胞自己寛容制御
田中伸弥
2021.1
Research Projects
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自己関連疾患を制御する末梢自己反応性CD4陽性T細胞についての包括的理解
2022 - 2028
科学技術振興調整費 (文部科学省)
Authorship：Principal investigator Grant type：Contract research
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末梢自己反応性B細胞の生体恒常性維持における役割の解明
Grant number：22H03112 2022 - 2026
日本学術振興会 科学研究費助成事業 基盤研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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抗原選択的免疫応答制御を実現する為の基盤システムの構築
Grant number：22K19547 2022 - 2024
日本学術振興会 科学研究費助成事業 挑戦的研究（萌芽）
Authorship：Principal investigator Grant type：Scientific research funding
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自己反応性シンギュラリティT細胞をラベリングする新規システムの構築と動態解析
Grant number：2 1 H 0 0 4 2 9 2021 - 2023
日本学術振興会・文部科学省 科学研究費助成事業 新学術領域研究
Authorship：Principal investigator Grant type：Scientific research funding
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制御性B細胞を用いた物質共生制御
Grant number：21H05530 2021 - 2022
日本学術振興会・文部科学省 科学研究費助成事業 学術変革領域研究(A)
Authorship：Principal investigator Grant type：Scientific research funding
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自己反応性シンギュラリティT細胞をラベリングする新規システムの構築と動態解析
Grant number：21H00429 2021 - 2022
日本学術振興会・文部科学省 科学研究費助成事業 新学術領域研究
Authorship：Principal investigator Grant type：Scientific research funding
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DNA脱メチル化酵素Tetによる免疫寛容メカニズムの解明
Grant number：19K08883 2019 - 2021
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
Class subject
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免疫学・T細胞性免疫応答
2024.4 - 2024.9 First semester
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免疫学・T細胞性免疫応答
2023.4 - 2023.9 First semester
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免疫学・T細胞性免疫応答、液性免疫応答
2022.4 - 2022.9 First semester
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免疫学・獲得免疫 (T, B細胞)
2021.4 - 2021.9 First semester