PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A-producing γδ T cells Reviewed International journal

220 ( 2 )   2022.12

MHC class II inhibits the generation of IL-17A(+) V gamma 6 gamma delta T cells in the thymus at perinatal stage Reviewed International journal

Shinya Hatano, Keiichiro Mine, Naoto Noguchi, Mitsuru Matsumoto, Yoshihiro Baba, Yasunobu Yoshikai

EUROPEAN JOURNAL OF IMMUNOLOGY   52 ( 8 )   1366 - 1368   2022.5

Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci Reviewed International journal

Hiroyuki Satofuka, Satoshi Abe, Takashi Moriwaki, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Kyotaro Yamazaki, Genki Hichiwa, Kayoko Morimoto, Haruka Takayama, Yuji Nakayama, Shinya Hatano, Yutaro Yada, Yasufumi Murakami, Yoshihiro Baba, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki

NATURE COMMUNICATIONS   13 ( 1 )   2022.4

Dermal Vγ6 ⁺ γδ T17 Cells are Involved in Skin Pressure Ulcers in Mice Reviewed International journal

2022.1

A blend of broadly-reactive and pathogen-selected V gamma 4 V delta 1 T cell receptors confer broad bacterial reactivity of resident memory gamma delta T cells Reviewed International journal

Camille Khairallah, Julie A. Bettke, Oleksandr Gorbatsevych, Zhijuan Qiu, Yue Zhang, Kyungjin Cho, Kwang Soon Kim, Timothy H. Chu, Jessica N. Imperato, Shinya Hatano, Galina Romanov, Yasunobo Yoshikai, Lynn Puddington, Charles D. Surh, James B. Bliska, Adrianus W. M. van der Velden & Brian S. Sheridan

MUCOSAL IMMUNOLOGY   2021.8

V gamma 6(+) gamma delta T cells are critical for protection against infection by Escherichia coli in mice Reviewed International journal

Tun X, Hatano S, Mine K, Noguchi N, Iwakura Y, Sun X, Yoshikai Y.

EUROPEAN JOURNAL OF IMMUNOLOGY   2021.4

gamma delta T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Reviewed International journal

MUCOSAL IMMUNOLOGY   2020.5

Impaired upregulation of Stat2 gene restrictive to pancreatic beta-cells is responsible for virus-induced diabetes in DBA/2 mice Reviewed International journal

Mine K, Nagafuchi S, Hatano S, Tanaka K, Mori H, Takahashi H, Anzai K, Yoshikai Y.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   521 ( 4 )   853 - 860   2020.1

Development of a new monoclonal antibody specific to mouse V gamma 6 chain Reviewed International journal

Hatano S, Tun X, Noguchi N, Yue D, Yamada H, Sun X, Matsumoto M, Yoshikai Y

LIFE SCIENCE ALLIANCE   2 ( 3 )   2019.6

Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion into erythrocytes Reviewed International journal

Ito D, Takashima E, Yamasaki T, Hatano S, Hasegawa T, Miura K, Morita M, Thongkukiatkul A, Diakite M, Long CA, Sattabongkot J, Udomsangpetch R, Iriko H, Ishino T, Tsuboi T

PARASITOLOGY INTERNATIONAL   68 ( 1 )   87 - 91   2019.2

Interleukin-21 Induces Short-Lived Effector CD8(+) T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice Reviewed International journal

Noguchi N, Nakamura R, Hatano S, Yamada H, Sun X, Ohara N, Yoshikai Y

INFECTION AND IMMUNITY   86 ( 8 )   2018.8

Two Types of Interleukin 17A-Producing gamma delta T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae Reviewed International journal

Murakami T, Hatano S, Yamada H, Iwakura Y and Yoshikai Y

JOURNAL OF INFECTIOUS DISEASES   214 ( 11 )   1752 - 1761   2016.12

IL-21 inhibits IL-17A-producing T-cell response after infection with Bacillus Calmette-Guerin via induction of apoptosis Reviewed International journal

Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X,Ohara N and Yoshikai Y

INNATE IMMUNITY   22 ( 8 )   588 - 597   2016.11

Recombinant Mycobacterium bovis bacillus Calmette-Guerin expressing Ag85B-IL-7 fusion protein enhances IL-17A-producing innate gamma delta T cells Reviewed International journal

Hatano S, Tamura T, Umemura M, Matsuzaki G, Ohara N and Yoshikai Y

VACCINE   34 ( 22 )   2490 - 2495   2016.5

Scavenger receptor for lipoteichoic acid is involved in the potent ability of Lactobacillus plantarum strain L-137 to stimulate production of interleukin-12p40 Reviewed International journal

Hatano S, Hirose Y, Yamamoto Y, Murosaki S, Yoshikai Y

INTERNATIONAL IMMUNOPHARMACOLOGY   25 ( 2 )   321 - 331   2015.4

A Genome-Wide Analysis Identifies a Notch-RBP-J kappa-IL-7R alpha Axis That Controls IL-17-Producing gamma delta T Cell Homeostasis in Mice Reviewed International journal

Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K and Yoshikai Y

JOURNAL OF IMMUNOLOGY   194 ( 1 )   243 - 251   2015.1

IFN-gamma-Producing and IL-17-Producing gamma delta T Cells Differentiate at Distinct Developmental Stages in Murine Fetal Thymus Reviewed International journal

Shibata K, Yamada H, Nakamura M, Hatano S, Katsuragi Y, Kominami R and Yoshikai Y

JOURNAL OF IMMUNOLOGY   192 ( 5 )   2210 - 2218   2014.3

Characteristics of Vγ6+ γδ T cells in mice using novel antibody specific for Vγ6 chain

第47回日本免疫学会学術集会  2018.12 

γδT 細胞による生体防御は個体発生を繰り返す

畑野　晋也

2019年度日本生体防御学会奨励賞受賞講演  2019.9 

The Bruton’s tyrosine kinase (Btk) inhibitor acalabrutinib suppress LPS-induced sepsis via inhibition of marginal zone B cells activation International conference

第51回日本免疫学会学術集会  2022.12 

Vγ6 γδT 細胞の分化と維持機構の解析

畑野　晋也

新学術領領域研究「ネオ・セルフの⽣生成・機能・構造」 第3回 若手の会  2020.1 

Development of a recombinant BCG expressing murine IL-7 as a novel vaccine against tuberculosis

2015.3 

マウスにおける新規IFN-γ産生γδT細胞サブセットの解析

畑野晋也、柴田健輔、山田久方、吉開泰信

第26回日本生体防御学会学術総会  2015.7 

Newly identified DN2-γδ T cells developing in Bcl11b-independent manner

第68回日本細菌学会九州支部総会  2015.9 

Newly identified BCL11b-independent γδ T cell subset in the periphery in mice

畑野晋也、村上哲晋、松村友美子、山田久方、吉開泰信

第89回日本細菌学会総会  2016.3 

Bcl11b非依存性primitive γδ T cellによる感染防御機構

畑野 晋也, 村上 哲晋, 野口 直人, 松村 友美子, 山田 久方, 吉開 泰信

第27回日本生体防御学会学術総会  2016.7 

Bcl11b ⾮依存的に発⽣するCD5−NK1.1+ γδ T 細胞は早期の感染防御に関与する

畑野晋也、村上哲晋、野口直人、山田久方、吉開泰信

新学術領域研究「ネオ･セルフの⽣成･機能･構造」第1 回 若⼿の会  2018.1 

Bcl11b-independent CD5−NK1.1+ γδ T cells participate in early protection against Listeria infection

畑野晋也、村上哲晋、野口直人、山田久方、吉開泰信

第91回細菌学会総会  2018.3 

マウスVγ6陽性細胞の特性–新規抗体を用いて–

畑野 晋也、吉開 泰信

新学術領域「ネオ･セルフ」第3回 領域全体班会議  2018.7 

新規抗マウスVγ6抗体を用いたVγ6リガンドの探索

畑野 晋也

新学術領域研究 ネオ･セルフの⽣成･機能･構造 第2 回若⼿の会  2019.1 

The analysis of roles of Vγ6 γδ T cells in host defense using a new monoclonal antibody specific to mouse Vγ6 chain

2019.9 

新規ＩＦＮ－γ産生γδＴ細胞サブセットの解析

Grant number：17J03389  2017 - 2018

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