Updated on 2024/10/07

Information

 

写真a

 
HATANO SHINYA
 
Organization
Medical Institute of Bioregulation Research Center for Systems Immunology Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926426839

Degree

  • Ph. D.

Research Interests・Research Keywords

  • Research theme:development of B cell, analysis of long lived B cell

    Keyword:B cell, antibody, plasma cell, IL-10,

    Research period: 2019.10 - 2020.7

Awards

  • 2019年度日本生体防御学会奨励賞

    2019.9   日本生体防御学会  

  • 第44回日本免疫学会学術集会 ベストプレゼンテーション賞

    2015.11   日本免疫学会  

  • 第68回日本細菌学会九州支部総会 若手奨励賞

    2015.9   日本細菌学会  

Papers

  • CD5(-)NK1.1(+) gamma delta T Cells that Develop in a Bcl11b-Independent Manner Participate in Early Protection against Infection Reviewed International journal

    Hatano S, Murakami T, Noguchi N, Yamada H and Yoshikai Y

    CELL REPORTS   21 ( 5 )   1191 - 1202   2017.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2017.10.007

  • Bruton’s tyrosine kinase inhibition limits endotoxic shock by suppressing IL-6 production by marginal zone B cells in mice Reviewed International journal

    15   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2024.1388947

  • Dectin-1 signaling on colonic gamma delta T cells promotes psychosocial stress responses Reviewed International journal

    Xiaolei Zhu, Shinji Sakamoto, Chiharu Ishii, Matthew D. Smith, Koki Ito, Mizuho Obayashi, Lisa Unger, Yuto Hasegawa, Shunya Kurokawa, Taishiro Kishimoto, Hui Li, Shinya Hatano, Tza-Huei Wang, Yasunobu Yoshikai, Shin-ichi Kano, Shinji Fukuda, Kenji Sanada, Peter A. Calabresi, Atsushi Kamiya

    NATURE IMMUNOLOGY   24 ( 4 )   625 - 636   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41590-023-01447-8

  • PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A-producing γδ T cells Reviewed International journal

    220 ( 2 )   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20211431

  • MHC class II inhibits the generation of IL-17A(+) V gamma 6 gamma delta T cells in the thymus at perinatal stage Reviewed International journal

    Shinya Hatano, Keiichiro Mine, Naoto Noguchi, Mitsuru Matsumoto, Yoshihiro Baba, Yasunobu Yoshikai

    EUROPEAN JOURNAL OF IMMUNOLOGY   52 ( 8 )   1366 - 1368   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/eji.202149542

  • Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci Reviewed International journal

    Hiroyuki Satofuka, Satoshi Abe, Takashi Moriwaki, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Kyotaro Yamazaki, Genki Hichiwa, Kayoko Morimoto, Haruka Takayama, Yuji Nakayama, Shinya Hatano, Yutaro Yada, Yasufumi Murakami, Yoshihiro Baba, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki

    NATURE COMMUNICATIONS   13 ( 1 )   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-022-29421-2

  • Dermal Vγ6 + γδ T17 Cells are Involved in Skin Pressure Ulcers in Mice Reviewed International journal

    2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jid.2021.12.030

  • A blend of broadly-reactive and pathogen-selected V gamma 4 V delta 1 T cell receptors confer broad bacterial reactivity of resident memory gamma delta T cells Reviewed International journal

    Camille Khairallah, Julie A. Bettke, Oleksandr Gorbatsevych, Zhijuan Qiu, Yue Zhang, Kyungjin Cho, Kwang Soon Kim, Timothy H. Chu, Jessica N. Imperato, Shinya Hatano, Galina Romanov, Yasunobo Yoshikai, Lynn Puddington, Charles D. Surh, James B. Bliska, Adrianus W. M. van der Velden & Brian S. Sheridan

    MUCOSAL IMMUNOLOGY   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41385-021-00447-x

  • V gamma 6(+) gamma delta T cells are critical for protection against infection by Escherichia coli in mice Reviewed International journal

    Tun X, Hatano S, Mine K, Noguchi N, Iwakura Y, Sun X, Yoshikai Y.

    EUROPEAN JOURNAL OF IMMUNOLOGY   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/eji.202049010

  • gamma delta T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Reviewed International journal

    MUCOSAL IMMUNOLOGY   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41385-020-0305-7

  • Impaired upregulation of Stat2 gene restrictive to pancreatic beta-cells is responsible for virus-induced diabetes in DBA/2 mice Reviewed International journal

    Mine K, Nagafuchi S, Hatano S, Tanaka K, Mori H, Takahashi H, Anzai K, Yoshikai Y.

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   521 ( 4 )   853 - 860   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2019.10.193

  • Development of a new monoclonal antibody specific to mouse V gamma 6 chain Reviewed International journal

    Hatano S, Tun X, Noguchi N, Yue D, Yamada H, Sun X, Matsumoto M, Yoshikai Y

    LIFE SCIENCE ALLIANCE   2 ( 3 )   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.26508/lsa.201900363

  • Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion into erythrocytes Reviewed International journal

    Ito D, Takashima E, Yamasaki T, Hatano S, Hasegawa T, Miura K, Morita M, Thongkukiatkul A, Diakite M, Long CA, Sattabongkot J, Udomsangpetch R, Iriko H, Ishino T, Tsuboi T

    PARASITOLOGY INTERNATIONAL   68 ( 1 )   87 - 91   2019.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.parint.2018.10.006

  • Interleukin-21 Induces Short-Lived Effector CD8(+) T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice Reviewed International journal

    Noguchi N, Nakamura R, Hatano S, Yamada H, Sun X, Ohara N, Yoshikai Y

    INFECTION AND IMMUNITY   86 ( 8 )   2018.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.00147-18

  • Two Types of Interleukin 17A-Producing gamma delta T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae Reviewed International journal

    Murakami T, Hatano S, Yamada H, Iwakura Y and Yoshikai Y

    JOURNAL OF INFECTIOUS DISEASES   214 ( 11 )   1752 - 1761   2016.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/infdis/jiw443

  • IL-21 inhibits IL-17A-producing T-cell response after infection with Bacillus Calmette-Guerin via induction of apoptosis Reviewed International journal

    Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X,Ohara N and Yoshikai Y

    INNATE IMMUNITY   22 ( 8 )   588 - 597   2016.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1753425916664125

  • Recombinant Mycobacterium bovis bacillus Calmette-Guerin expressing Ag85B-IL-7 fusion protein enhances IL-17A-producing innate gamma delta T cells Reviewed International journal

    Hatano S, Tamura T, Umemura M, Matsuzaki G, Ohara N and Yoshikai Y

    VACCINE   34 ( 22 )   2490 - 2495   2016.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.vaccine.2016.03.096

  • Scavenger receptor for lipoteichoic acid is involved in the potent ability of Lactobacillus plantarum strain L-137 to stimulate production of interleukin-12p40 Reviewed International journal

    Hatano S, Hirose Y, Yamamoto Y, Murosaki S, Yoshikai Y

    INTERNATIONAL IMMUNOPHARMACOLOGY   25 ( 2 )   321 - 331   2015.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.intimp.2015.02.011

  • A Genome-Wide Analysis Identifies a Notch-RBP-J kappa-IL-7R alpha Axis That Controls IL-17-Producing gamma delta T Cell Homeostasis in Mice Reviewed International journal

    Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K and Yoshikai Y

    JOURNAL OF IMMUNOLOGY   194 ( 1 )   243 - 251   2015.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1401619

  • IFN-gamma-Producing and IL-17-Producing gamma delta T Cells Differentiate at Distinct Developmental Stages in Murine Fetal Thymus Reviewed International journal

    Shibata K, Yamada H, Nakamura M, Hatano S, Katsuragi Y, Kominami R and Yoshikai Y

    JOURNAL OF IMMUNOLOGY   192 ( 5 )   2210 - 2218   2014.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1302145

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Presentations

  • Development of IL-17A+ Vγ6 γδ T cells in mouse thymus

    第48回日本免疫学会学術集会  2019.12 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Identification of two distinct IFN-γ-producing γδ T cell subsets in mice

    畑野晋也, 柴田健輔, 山田久方, 吉開泰信

    第43回日本免疫学会学術集会  2014.12 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Analysis of a novel subset of IFN-γ-producing DN2a γδ T cells in the periphery of mice

    第44回日本免疫学会学術集会  2015.11 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • A critical role of primitive γδ T cells developing (from DN2a stage) independently of Bcl11b in early host defense

    第45回日本免疫学会学術集会  2016.12 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Development of new monoclonal antibody specific for murine Vγ6 chain

    第46回日本免疫学会学術集会  2017.12 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Characteristics of Vγ6+ γδ T cells in mice using novel antibody specific for Vγ6 chain

    第47回日本免疫学会学術集会  2018.12 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • γδT 細胞による生体防御は個体発生を繰り返す

    畑野 晋也

    2019年度日本生体防御学会奨励賞受賞講演  2019.9 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • The Bruton’s tyrosine kinase (Btk) inhibitor acalabrutinib suppress LPS-induced sepsis via inhibition of marginal zone B cells activation International conference

    第51回日本免疫学会学術集会  2022.12 

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    Event date: 2024.5

    Language:English  

    Venue:熊本   Country:Japan  

  • Vγ6 γδT 細胞の分化と維持機構の解析

    畑野 晋也

    新学術領領域研究「ネオ・セルフの⽣生成・機能・構造」 第3回 若手の会  2020.1 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Development of a recombinant BCG expressing murine IL-7 as a novel vaccine against tuberculosis

    2015.3 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • マウスにおける新規IFN-γ産生γδT細胞サブセットの解析

    畑野晋也、柴田健輔、山田久方、吉開泰信

    第26回日本生体防御学会学術総会  2015.7 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Newly identified DN2-γδ T cells developing in Bcl11b-independent manner

    第68回日本細菌学会九州支部総会  2015.9 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Newly identified BCL11b-independent γδ T cell subset in the periphery in mice

    畑野晋也、村上哲晋、松村友美子、山田久方、吉開泰信

    第89回日本細菌学会総会  2016.3 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Bcl11b非依存性primitive γδ T cellによる感染防御機構

    畑野 晋也, 村上 哲晋, 野口 直人, 松村 友美子, 山田 久方, 吉開 泰信

    第27回日本生体防御学会学術総会  2016.7 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Bcl11b ⾮依存的に発⽣するCD5−NK1.1+ γδ T 細胞は早期の感染防御に関与する

    畑野晋也、村上哲晋、野口直人、山田久方、吉開泰信

    新学術領域研究「ネオ・セルフの⽣成・機能・構造」第1 回 若⼿の会  2018.1 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • Bcl11b-independent CD5−NK1.1+ γδ T cells participate in early protection against Listeria infection

    畑野晋也、村上哲晋、野口直人、山田久方、吉開泰信

    第91回細菌学会総会  2018.3 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • マウスVγ6陽性細胞の特性–新規抗体を用いて–

    畑野 晋也、吉開 泰信

    新学術領域「ネオ・セルフ」第3回 領域全体班会議  2018.7 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • 新規抗マウスVγ6抗体を用いたVγ6リガンドの探索

    畑野 晋也

    新学術領域研究 ネオ・セルフの⽣成・機能・構造 第2 回若⼿の会  2019.1 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

  • The analysis of roles of Vγ6 γδ T cells in host defense using a new monoclonal antibody specific to mouse Vγ6 chain

    2019.9 

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    Event date: 2020.1

    Language:Japanese  

    Country:Japan  

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Professional Memberships

  • 日本細菌学会

  • 日本生体防御学会

  • 日本免疫学会

Academic Activities

  • 免疫サマースクール2023事務局・スタッフ

    第24回免疫サマースクール  ( 福岡 ) 2023.8

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    Type:Competition, symposium, etc. 

Research Projects

  • 新規加齢性B細胞解析による液性免疫老化の誘導機序の解明

    Grant number:24K10258  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新規加齢性B細胞による液性免疫老化の誘導機序

    2023 - 2027

    武田科学振興材団 医学系研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 新規加齢性B細胞サブセットの解析による免疫老化メカニズムの解明

    Grant number:22K15497  2022 - 2023

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • B-1細胞における制御性B細胞および自己抗体産生細胞への分化機構の解明

    Grant number:20K16288  2020 - 2021

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • B細胞寿命を起点とした免疫老化誘導機序の解明

    2020

    令和2年度QRプログラム わかばチャレンジ

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 新規IFN-γ産生γδT細胞サブセットの解析

    Grant number:17J03389  2017 - 2018

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Class subject

  • 生体応答制御学

    2023.10 - 2024.3   Second semester