2025/06/30 更新

お知らせ

 

写真a

ヤダ ユウタロウ
矢田 裕太郎
YADA YUTARO
所属
生体防御医学研究所 個体機能制御学部門 助教
職名
助教
連絡先
メールアドレス
電話番号
0926426838
外部リンク

学位

  • 医学博士

研究テーマ・研究キーワード

  • 研究テーマ: 胚中心B細胞の選択におけるメカニズムの解析

    研究キーワード: 胚中心、自己免疫、抗体

    研究期間: 2024年4月

受賞

  • 最優秀論文賞

    2024年11月   九州小児科学会   STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells

    矢田 裕太郎

     詳細を見る

    受賞区分:国内学会・会議・シンポジウム等の賞 

論文

  • STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells 査読 国際誌

    Yada, Y; Matsumoto, M; Inoue, T; Baba, A; Higuchi, R; Kawai, C; Yanagisawa, M; Kitamura, D; Ohga, S; Kurosaki, T; Baba, Y

    JOURNAL OF EXPERIMENTAL MEDICINE   221 ( 1 )   2024年1月   ISSN:0022-1007 eISSN:1540-9538

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Experimental Medicine  

    Positive selection of high-affinity germinal center (GC) B cells is driven by antigen internalization through their B cell receptor (BCR) and presentation to follicular helper T cells. However, the requirements of BCR signaling in GC B cells remain poorly understood. Store-operated Ca2+ entry, mediated by stromal interacting molecule 1 (STIM1) and STIM2, is the main Ca2+ influx pathway triggered by BCR engagement. Here, we showed that STIM-deficient B cells have reduced B cell competitiveness compared with wild-type B cells during GC responses. B cell–specific deletion of STIM proteins decreased the number of high-affinity B cells in the late phase of GC formation. STIM deficiency did not affect GC B cell proliferation and antigen presentation but led to the enhancement of apoptosis due to the impaired upregulation of anti-apoptotic Bcl2a1. STIM-mediated activation of NFAT was required for the expression of Bcl2a1 after BCR stimulation. These findings suggest that STIM-mediated survival signals after antigen capture regulate the optimal selection and maintenance of GC B cells.

    DOI: 10.1084/jem.20222178

    Web of Science

    Scopus

    PubMed

    researchmap

  • Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity

    Imabayashi, K; Yada, Y; Kawata, K; Yoshimura, M; Iwasaki, T; Baba, A; Harada, A; Akashi, K; Niiro, H; Baba, Y

    SCIENCE ADVANCES   11 ( 16 )   eadt8199   2025年4月   ISSN:2375-2548

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Science Advances  

    Age-associated B cells (ABCs) with autoreactive properties accumulate with age and expand prematurely in autoimmune diseases. However, the mechanisms behind ABC generation and maintenance remain poorly understood. We show that continuous B cell receptor (BCR) signaling is essential for ABC development from anergic B cells in aged and autoimmune mice. ABCs exhibit constitutive BCR activation, with surface BCRs being internalized. Notably, anergic B cells, but not nonautoreactive B cells, contributed to ABC formation in these models. Anergic B cells also showed a greater propensity for in vitro differentiation into ABCs, which was inhibited by the expression of the transcription factor Nr4a1. Bruton’s tyrosine kinase (Btk), a key BCR signaling component, was constitutively activated in ABCs from aged and autoimmune mice as well as patients with lupus. Inhibiting Btk reduced ABC numbers and ameliorated the pathogenicity of lupus mice. Our findings reveal critical mechanisms underlying ABC development and offer previously unrecognized therapeutic insights for autoimmune diseases.

    DOI: 10.1126/sciadv.adt8199

    Web of Science

    Scopus

    PubMed

    researchmap

  • TOPICS 免疫学 B細胞受容体によるカルシウムシグナルが制御する胚中心B細胞ポジティブセレクション

    矢田 裕太郎, 馬場 義裕

    医学のあゆみ   292 ( 8 )   654 - 655   2025年2月   ISSN:00392359

     詳細を見る

    出版者・発行元:医歯薬出版  

    DOI: 10.32118/ayu292080654

    CiNii Research

  • Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis

    Sonoda, M; Kinoshita, K; Harada, N; Park, S; Adachi, S; Yada, Y; Eguchi, K; Fujiwara, T; Kido-Nakahara, M; Kinjo, N; Ishimura, M; Ohga, S

    PEDIATRIC RHEUMATOLOGY   23 ( 1 )   6   2025年1月   eISSN:1546-0096

     詳細を見る

    記述言語:英語   出版者・発行元:Pediatric Rheumatology  

    Background: Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory disease of unknown cause, predominantly affecting teens and young adults. The early diagnosis and management are challenging due to the lack of reliable diagnostic markers and the occasional intractable cases despite conventional anti-inflammatory treatments. Janus kinase (JAK) inhibitors have recently shown potential utility; however, reports on their use for pediatric patients with CNO remain limited, and no established biomarkers exist to monitor disease activity. We aimed to investigate the pathophysiology of CNO and explore the rapid testing methods for accurate diagnosis and also assessing the disease activity. Methods: We assessed intracellular phosphorylation of signal transducer and activator of transcription 1 (pSTAT1) in peripheral blood monocytes or T cells following interferon-gamma (IFNγ) stimulation, using flow cytometry in 9 patients under 15 years old with CNO. The pSTAT1 expression levels were compared with those in patients with STAT1-gain of function (STAT1-GOF) mutations (n = 5), other autoinflammatory diseases (n = 7), and healthy controls. Clinical and immunological data were monitored in 4 patients with intractable CNO treated with adjunctive JAK inhibitors, focusing on scoring scales, imaging data, lymphocyte subsets, cytokine profiles, and pSTAT1 levels. Results: Monocyte pSTAT1 expression after IFNγ stimulation was elevated at diagnosis or during active CNO, similar to levels observed in STAT1-GOF cases. The pSTAT1 levels in CNO patients were significantly higher than those in other autoinflammatory diseases (p = 0.024) or controls (p < 0.001). Notably, pSTAT1 levels in CNO monocytes fluctuated with disease activity, decreasing in 5 patients during clinical remission following conventional therapies (p = 0.016). In four intractable cases, pSTAT1 levels remained high despite conventional treatments but significantly decreased after initiating JAK inhibitors (p = 0.036). This reduction correlated with improved patient pain visual analog scale (p = 0.008), CNO clinical disease activity score (p = 0.029), and better bone and joint imaging, though cytokine levels remained unchanged. Conclusions: The monocyte pSTAT1 levels after IFNγ stimulation reflect the activity of CNO, indicating the diagnostic utility as well as the monitoring effect of disease control. Adjunctive JAK inhibitors successfully controlled inflammation in treatment-resistant cases. Rapid pSTAT1 testing may help reduce osteo-articular complications, although the long-term adverse effects and resistance should be further investigated.

    DOI: 10.1186/s12969-025-01059-6

    Web of Science

    Scopus

    PubMed

  • 特集 小児の鉄代謝 6.鉄過剰症

    矢田 裕太郎, 江口 克秀, 石村 匡崇, 落合 正行, 大賀 正一

    小児科   65 ( 9 )   852 - 856   2024年9月   ISSN:00374121

     詳細を見る

    出版者・発行元:金原出版  

    DOI: 10.18888/sh.0000003140

    CiNii Research

  • 特集 公費補助制度を使いこなす! Ⅱ.各論 慢性活動性EBウイルス病

    矢田 裕太郎, 石村 匡崇, 大賀 正一

    小児科診療   87 ( 8 )   1060 - 1063   2024年8月   ISSN:03869806

     詳細を見る

    出版者・発行元:診断と治療社  

    DOI: 10.34433/pp.0000001146

    CiNii Research

  • Post-transplant <i>Schizophyllum commune</i> abscess in a pediatric patient with chronic granulomatous disease 査読

    Yada, Y; Shiraishi, A; Ishimura, M; Eguchi, K; Motomura, Y; Kibe, Y; Kamei, K; Ohga, S

    JOURNAL OF INFECTION AND CHEMOTHERAPY   29 ( 2 )   219 - 222   2023年2月   ISSN:1341-321X eISSN:1437-7780

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Infection and Chemotherapy  

    Schizophyllum commune is a widely distributed basidiomycete fungus that occasionally causes sinusitis or allergic bronchopulmonary mycosis. The invasive infection mostly occurs in immunocompromised adults. The number of reports on S. commune infection have increased in this decade due to the expansion of diagnostic techniques and awareness in clinical practice. However, S.commune infection in patients with primary immunodeficiencies has not been reported yet. Here, we described S. commune-abscesses developed in the brain and lung of a boy with chronic granulomatous disease (CGD) after allogenic hematopoietic cell transplantation (HCT). A 12-year-old CGD patient developed febrile neutropenia from day 4 after HCT, followed by chest pain on day 23. He had no obvious infection before HCT. Diagnostic imaging revealed disseminated lung and brain abscesses. He received administration of voriconazole, and his symptoms improved after engraftment. Chronic administration of voriconazole had also a favorable therapeutic response to brain lesion. A part of the fungus ball exhaled by the patient was cultured to develop a filamentous fungus. S. commune was identified by the analysis of the 28S rRNA gene. The catalase test was positive for S. commune, indicating that S. commune had virulence in this patient with CGD. The assessment of specific-IgG to S. commune suggested peri-transplant infection, although colonization was not excluded. This rare pediatric case of S. commune infection highlights that CGD patients are vulnerable to invasive infection, especially when undergoing HCT.

    DOI: 10.1016/j.jiac.2022.10.015

    Web of Science

    Scopus

    PubMed

    researchmap

  • 慢性肉芽腫性疾患小児患者における移植後のスエヒロタケ(Schizophyllum commune)膿瘍(Post-transplant Schizophyllum commune abscess in a pediatric patient with chronic granulomatous disease)

    Yada Yutaro, Shiraishi Akira, Ishimura Masataka, Eguchi Katsuhide, Motomura Yoshitomo, Kibe Yasushi, Kamei Katsuhiko, Ohga Shouichi

    Journal of Infection and Chemotherapy   29 ( 2 )   219 - 222   2023年2月   ISSN:1341-321X

     詳細を見る

    記述言語:英語   出版者・発行元:エルゼビア・ジャパン(株)  

    症例は12歳男児で、慢性肉芽腫性疾患の治癒を目的とした臍帯血移植を受けるために当院に入院した。ブスルファンとフルダラビンの移植前処置後に臍帯血を用いた同種造血幹細胞移植を施行した。移植後4日目から発熱性好中球減少症を発症し、23日目に胸痛を発症した。移植前に明らかな感染症はなかった。画像診断で播種性肺膿瘍および脳膿瘍が認められた。ボリコナゾール投与を行い、生着後、症状は改善した。ボリコナゾールの慢性投与により、脳膿瘍の治療効果も良好であった。患者の吐き出した菌球の一部を培養したところ、糸状菌が発生した。28S rRNA遺伝子の解析によりSchizophyllum commune(スエヒロタケ)を同定した。カタラーゼテストはS.communeに陽性であり、S.communeが本症例に病原性を有することが示された。S.communeに対する特異的IgGの評価から、定着は否定されなかったが、移植での周術期感染が示唆された。

  • Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci 査読

    Satofuka, H; Abe, S; Moriwaki, T; Okada, A; Kazuki, K; Tanaka, H; Yamazaki, K; Hichiwa, G; Morimoto, K; Takayama, H; Nakayama, Y; Hatano, S; Yada, Y; Murakami, Y; Baba, Y; Oshimura, M; Tomizuka, K; Kazuki, Y

    NATURE COMMUNICATIONS   13 ( 1 )   1841   2022年12月   eISSN:2041-1723

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature Communications  

    Trans-chromosomic (Tc) mice carrying mini-chromosomes with megabase-sized human immunoglobulin (Ig) loci have contributed to the development of fully human therapeutic monoclonal antibodies, but mitotic instability of human mini-chromosomes in mice may limit the efficiency of hybridoma production. Here, we establish human antibody-producing Tc mice (TC-mAb mice) that stably maintain a mouse-derived, engineered chromosome containing the entire human Ig heavy and kappa chain loci in a mouse Ig-knockout background. Comprehensive, high-throughput DNA sequencing shows that the human Ig repertoire, including variable gene usage, is well recapitulated in TC-mAb mice. Despite slightly altered B cell development and a delayed immune response, TC-mAb mice have more subsets of antigen-specific plasmablast and plasma cells than wild-type mice, leading to efficient hybridoma production. Our results thus suggest that TC-mAb mice offer a valuable platform for obtaining fully human therapeutic antibodies, and a useful model for elucidating the regulation of human Ig repertoire formation.

    DOI: 10.1038/s41467-022-29421-2

    Web of Science

    Scopus

    PubMed

    researchmap

  • Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes 査読

    Chong, PF; Torio, M; Fujii, F; Hirata, Y; Matsuoka, W; Sonoda, Y; Ichimiya, Y; Yada, Y; Kaku, N; Ishimura, M; Sasazuki, M; Koga, Y; Sanefuji, M; Sakai, Y; Ohga, S

    EUROPEAN JOURNAL OF CLINICAL NUTRITION   76 ( 11 )   1618 - 1621   2022年11月   ISSN:0954-3007 eISSN:1476-5640

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:European Journal of Clinical Nutrition  

    Vitamin deficiencies are an emerging concern in the management of children with autism spectrum disorder (ASD). Particular attention is required for recognizing the variable signs caused by unbalanced food intakes. We herein report two patients with multiple vitamin deficiencies who needed critical care showing different prognoses. Patient 1 with ‘Shoshin’ beriberi presenting with cardiac arrest had thiamine deficiency developed severe neurological sequelae despite rapid vitamin supplementation. Patient 2, who had leg pain and a limping gait, showed a rapid recovery with intravenous infusion and tube feeding after being diagnosed with scurvy. A literature search revealed several children with ASD with critically ill thiamine deficiency, but few reports documented a life-threatening condition in the form of cardiac arrest at the onset. Considering the high observation rate of food selectivity in children with ASD, early intervention is required to prevent the exacerbation of vitamin deficiencies to severe neurological disabilities.

    DOI: 10.1038/s41430-022-01170-x

    Web of Science

    Scopus

    PubMed

    researchmap

  • Progressive B cell depletion in human MALT1 deficiency 査読

    Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Yutaro Yada, Nina Lenhartová, Akira Shiraishi, Tamami Tanaka, Yasunari Sakai, Shouichi Ohga

    Clinical and Experimental Immunology   206 ( 3 )   237 - 247   2021年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (MALT1)-deficiency is a rare combined immunodeficiency characterized by recurrent infections, dermatitis and enteropathy. We herein investigate the immunological profiles of our patient and previously reported children with MALT1-deficiency. A mutation analysis was performed by targeted panel sequencing for primary immunodeficiency. Lymphocyte subset, activation and B cell differentiation were analyzed by flow cytometry and t-distributed stochastic neighbor embedding. Pneumocystis pneumonia developed in a 6-month-old Japanese infant with atopic dermatitis, enteritis and growth restriction. This infant showed agammaglobulinemia without lymphopenia. At 8 years of age, the genetic diagnosis of MALT1-deficiency was confirmed on a novel homozygous mutation of c.1102G>T, p.E368X. T cell stimulation tests showed impairments in the production of interleukin-2, phosphorylation of nuclear factor kappa B (NF-κB) p65 and differentiation of B cells. In combination with the literature data, we found that the number of circulatory B cells, but not T cells, were inversely correlated with the age of patients. The hematopoietic cell transplantation (HCT) successfully reconstituted the differentiation of mature B cells and T cells. These data conceptualize that patients with complete MALT1-deficiency show aberrant differentiation and depletion of B cells. The early diagnosis and HCT lead to a cure of the disease phenotype associated with the loss-of-function mutations in human CARD11.

    DOI: 10.1111/cei.13662

  • Brain-sparing cord blood transplantation for the borderline stage of adrenoleukodystrophy 査読

    Yutaro Yada, Michiko Torio, Yuhki Koga, Fumiya Yamashita, Takuya Ichimura, Katsuhide Eguchi, Masataka Ishimura, Yuichi Mushimoto, Akio Hiwatashi, Momoko Sasazuki, Ryutaro Kira, Yasunari Sakai, Shouichi Ohga

    Molecular Genetics and Metabolism Reports   28   2021年9月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Adrenoleukodystrophy (ALD) is an X-linked disorder characterized by rapidly progressive deterioration of neurocognitive functions and premature death. In addition to the difficulty in identifying the earliest signs of ALD, treatment-associated exacerbation of neurological symptoms has been an obstacle to achieve successful hematopoietic cell transplantation (HCT) for affected children. Case report: We report a 9-year-boy with ALD. He presented with impairment in social skills compatible to the diagnosis of autism spectrum disorder from 3 years of age. He showed progressive strabismus, slurred speech and dysmetria at 6 years of age. The head MRI showed symmetrical T2-hyperintense lesions in the occipital white matters with a gadolinium enhancement, which extended to the internal capsules. The Loes score was thus calculated as 13. Very-long-chain-fatty-acids were increased to 1.800 (C24:0/C22:0) and 0.077 (C26:0/C22:0) in leukocytes. Sanger sequencing confirmed the pathogenic variant in ABCD1 (NM_000033.4:p.Gly512Ser). After multidisciplinary discussions over the treatment options, we performed a cord blood HCT with a reduced intensity conditioning (fludarabine, melphalan and brain-sparing total body irradiation). He was fully recovered with >90&#37; chimerism of donor leukocytes at 55 days after HCT. He experienced three times of generalized seizures after discharge, that has been well controlled for 2 years without other complications or neurocognitive deteriorations. Conclusion: For patients with ALD on a borderline indication for HCT, brain-sparing irradiation might be an alternative option in reduced intensity conditioning. Careful decision-making process and tailored conditioning are critical for the successful outcome of HCT for children with ALD.

    DOI: 10.1016/j.ymgmr.2021.100778

  • Cytomegalovirus-Associated Hemolytic Anemia in an Infant Born to a Mother with Lupus 査読

    Shunsuke Yamamoto, Akira Shiraishi, Masataka Ishimura, Yoshitomo Motomura, Yutaro Yada, Hiroyuki Moriuchi, Shouichi Ohga

    Neonatology   118 ( 3 )   368 - 372   2021年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 31-day-old infant was admitted to the pediatric intensive care unit due to shock and anemia. The mother had systemic lupus erythematosus and direct antiglobulin test (DAT)-positive hemolytic anemia. The perinatal course of this infant and the mother was uneventful. Regular health check screenings revealed that activity, growth, and development were unremarkable at birth, 5, and 28 days of life. Passive immune hemolytic anemia due to neonatal lupus erythematosus was diagnosed based on a positive DAT for warm-type IgG antibodies, reticulocytosis, and lupus-specific antibodies at rehospitalization. It was complicated by cytomegalovirus (CMV) antigenemia. Umbilical cord blood and peripheral blood samples obtained from the infant at 5 days after birth were negative for CMV DNA. The infant was curatively treated by intensive care with repeated blood transfusions and antiviral therapy. This is the first report indicating that CMV infection exacerbates hemolytic anemia in patients with maternal red blood cell alloantibodies.

    DOI: 10.1159/000515770

  • Acute isolated Aspergillus appendicitis in pediatric leukemia 査読

    Yutaro Yada, Yuhki Koga, Hiroaki Ono, Yoshitomo Motomura, Genshiro Esumi, Kenichi Kohashi, Yasunori Muraosa, Katsuhiko Kamei, Toshiharu Matsuura, Yoshinao Oda, Shouichi Ohga

    Journal of Infection and Chemotherapy   26 ( 11 )   1229 - 1231   2020年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aspergillus is a widespread fungus in the environment, usually invades through the respiratory tract. Invasive aspergillosis is a fatal disseminated infection in immunocompromised hosts. Appendicitis occurs scarcely in patients with leukemia. We report a case of Aspergillus appendicitis that underwent an urgent appendectomy. An 11-year-old boy received the diagnosis of acute myeloid leukemia, because of the bone pain and results of the bone marrow study. He obtained a complete remission after cancer chemotherapy and received peripheral blood stem cell transplantation from a histocompatible sibling. Leukemia relapsed 5 months post-transplant. Induction therapy with etoposide, cytarabine and mitoxantrone was started on Candida prophylaxis. Fifteen days after the end of chemotherapy, he presented with febrile neutropenia and abdominal pain, that did not respond to broad-spectrum antibiotics. Serum levels of C-reactive protein, β-D-glucan and procalcitonin were unremarkable. Computed tomography scan revealed a swollen appendix and the adjacent tissue inflammation. An urgent appendectomy led to a tentative diagnosis of Aspergillus appendicitis based on the histopathological findings of many fungal hyphal forms. Panfungal polymerase chain reaction using DNA extracted from the lesion determined the pathogen of Aspergillus niger. There was no evidence of invasive aspergillosis. During the prolonged anti-fungal therapy, he achieved a remission of leukemia and underwent the second hematopoietic cell transplantation. To our knowledge, Aspergillus appendicitis was reported to occur in 5 leukemia patients. Four of them survived after appendectomy and one died from intestinal perforation. Early surgical intervention is mandatory for a cure of Aspergillus appendicitis in neutropenic patients on Candida prophylaxis.

    DOI: 10.1016/j.jiac.2020.07.016

▼全件表示

講演・口頭発表等

  • STIM-mediated store-operated calcium entry regulates positive selection and affinity maturation of germinal center B cells 国際共著 国際会議

    Yutaro Yada

    第33回ホットスプリングハーバー国際シンポジウム  2024年10月  第33回ホットスプリングハーバー国際シンポジウム事務局

     詳細を見る

    開催年月日: 2024年10月

    会議種別:シンポジウム・ワークショップ パネル(公募)  

  • STIM-mediated store-operated calcium influx regulates positive selection of germinal center B cells 国際共著 国際会議

    Yutaro Yada

    21st Biennial Meeting of The European Society for Immunodeficiencies  2024年10月  European Society for Immunodeficiency

     詳細を見る

    開催年月日: 2024年10月

    記述言語:英語   会議種別:ポスター発表  

    開催地:Marseille, France  

  • STIM-mediated store-operated calcium entry regulates positive selection and affinity maturation of germinal center B cells 国際共著 国際会議

    矢田 裕太郎

    APSID-JSIAD Congress 2024  2024年3月 

     詳細を見る

    開催年月日: 2024年3月

    記述言語:英語   会議種別:口頭発表(一般)  

    開催地:Tokyo, Japan  

  • 慢性肉芽腫症の臍帯血移植経過中に発症した侵襲性Schizophyllum commune感染症

    矢田 裕太郎, 本村 良知, 江口 克秀, 石村 匡崇, 大賀 正一

    日本小児感染症学会総会・学術集会プログラム・抄録集  2023年11月  (一社)日本小児感染症学会

     詳細を見る

    開催年月日: 2023年11月

    記述言語:日本語  

    researchmap

  • 若年性皮膚筋炎患者における筋炎特異的自己抗体別の臨床像と免疫学的プロファイル 単一施設後ろ向き研究

    朴 崇娟, 園田 素史, 石村 匡崇, 足立 俊一, 木下 恵志郎, 矢田 裕太郎, 江口 克秀, 白石 暁, 市村 裕輝, 沖山 奈緒子, 大賀 正一

    日本臨床免疫学会総会プログラム・抄録集  2023年10月  (一社)日本臨床免疫学会

     詳細を見る

    開催年月日: 2023年10月

    記述言語:日本語  

    researchmap

  • 難治性皮膚免疫、アレルギー疾患 若年性皮膚筋炎患者における筋炎特異的自己抗体別の臨床像と免疫学的プロファイル 単一施設後ろ向き研究

    朴 崇娟, 園田 素史, 石村 匡崇, 足立 俊一, 木下 恵志郎, 矢田 裕太郎, 江口 克秀, 白石 暁, 市村 裕輝, 沖山 奈緒子, 大賀 正一

    日本臨床免疫学会総会プログラム・抄録集  2023年10月  (一社)日本臨床免疫学会

     詳細を見る

    開催年月日: 2023年10月

    記述言語:日本語  

    researchmap

  • 治療抵抗性SAPHO症候群に対してJAK阻害剤を導入した3例の治療経過および免疫学的プロファイルの解析

    園田 素史, 石村 匡崇, 朴 崇娟, 原田 頌隆, 足立 俊一, 木下 恵志郎, 矢田 裕太郎, 江口 克秀, 白石 暁, 大賀 正一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2022年10月  (一社)日本小児リウマチ学会

     詳細を見る

    開催年月日: 2022年10月

    記述言語:日本語  

    researchmap

  • 難治性皮膚免疫、アレルギー疾患 若年性皮膚筋炎患者における筋炎特異的自己抗体別の臨床像と免疫学的プロファイル 単一施設後ろ向き研究

    朴 崇娟, 園田 素史, 石村 匡崇, 足立 俊一, 木下 恵志郎, 矢田 裕太郎, 江口 克秀, 白石 暁, 市村 裕輝, 沖山 奈緒子, 大賀 正一

    日本臨床免疫学会総会プログラム・抄録集  2023年10月  (一社)日本臨床免疫学会

     詳細を見る

    記述言語:日本語  

  • 若年性皮膚筋炎患者における筋炎特異的自己抗体別の臨床像と免疫学的プロファイル 単一施設後ろ向き研究

    朴 崇娟, 園田 素史, 石村 匡崇, 足立 俊一, 木下 恵志郎, 矢田 裕太郎, 江口 克秀, 白石 暁, 市村 裕輝, 沖山 奈緒子, 大賀 正一

    日本臨床免疫学会総会プログラム・抄録集  2023年10月  (一社)日本臨床免疫学会

     詳細を見る

    記述言語:日本語  

  • 治療抵抗性SAPHO症候群に対してJAK阻害剤を導入した3例の治療経過および免疫学的プロファイルの解析

    園田 素史, 石村 匡崇, 朴 崇娟, 原田 頌隆, 足立 俊一, 木下 恵志郎, 矢田 裕太郎, 江口 克秀, 白石 暁, 大賀 正一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2022年10月  (一社)日本小児リウマチ学会

     詳細を見る

    記述言語:日本語  

  • 治療抵抗性SAPHO症候群に対してJAK阻害剤を導入した3例の治療経過および免疫学的プロファイルの解析

    園田 素史, 石村 匡崇, 朴 崇娟, 原田 頌隆, 足立 俊一, 木下 恵志郎, 矢田 裕太郎, 江口 克秀, 白石 暁, 大賀 正一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2022年10月  (一社)日本小児リウマチ学会

     詳細を見る

    記述言語:日本語  

  • 慢性肉芽腫症の臍帯血移植経過中に発症した侵襲性Schizophyllum commune感染症

    矢田 裕太郎, 本村 良知, 江口 克秀, 石村 匡崇, 大賀 正一

    日本小児感染症学会総会・学術集会プログラム・抄録集  2023年11月  (一社)日本小児感染症学会

     詳細を見る

    記述言語:日本語  

  • 抗SARS-CoV-2免疫反応および抗体産生株 STIMを介した貯蔵作動性カルシウムの流入が胚中心B細胞の維持と選択を制御する(Anti SARS-CoV-2 immune responses and Antibody producers STIM-mediated store-operated calcium entry regulates maintenance and selection of germinal center B cells)

    Yada Yutaro, Matsumoto Masanori, Inoue Takeshi, Kitamura Daisuke, Kurosaki Tomohiro, Baba Yoshihiro

    日本免疫学会総会・学術集会記録  2022年11月  (NPO)日本免疫学会

     詳細を見る

    記述言語:英語  

  • 母体・胎児~新生児を血栓症から守る 新生児から成人期までに発症する特発性血栓症(EOT:Early-Onset Thrombophilia)の診療ガイドの概説

    落合 正行, 大賀 正一, 足立 俊一, 池田 勇八, 石黒 精, 石村 匡崇, 市山 正子, 内海 健, 江上 直樹, 江口 克秀, 大森 司, 荻原 建一, 角田 治美, 加藤 聖子, 康 東天, 木下 恵志郎, 木村 緑, 康 勝好, 小林 隆夫, 末延 聡一, 園田 素史, 多賀 崇, 武山 雅博, 津田 博子, 西久保 敏也, 根木 玲子, 野上 恵嗣, 原田 頌隆, 日野 もえ子, 古川 晶子, 堀田 多恵子, 本田 護, 松下 正, 松本 信也, 宮田 敏行, 森下 英理子, 安岡 和昭, 矢田 裕太郎, 山座 孝義, 山村 健一郎, 横田 奈津子, 横山 健次, 渡部 貴秀

    日本周産期・新生児医学会雑誌  2024年6月  (一社)日本周産期・新生児医学会

     詳細を見る

    記述言語:日本語  

  • B cell activation and differentiation Humanized BCR mice are a useful tool for analysis of autoreactive B cells(タイトル和訳中)

    Ito Rinka, Yada Yutaro, Kazuki Yasuhiro, Baba Yoshihiro

    日本免疫学会総会・学術集会記録  2024年11月  (NPO)日本免疫学会

     詳細を見る

    記述言語:英語  

▼全件表示

MISC

  • 【公費補助制度を使いこなす!】慢性活動性EBウイルス病

    矢田 裕太郎, 石村 匡崇, 大賀 正一

    小児科診療   87 ( 8 )   1060 - 1063   2024年8月   ISSN:0386-9806

     詳細を見る

    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    <文献概要>▽慢性活動性EBウイルス病(CAEBV)はその発症メカニズムがいまだ不明な難治性致死性疾患である.▽CAEBVは造血細胞移植を含む適切な治療によって,生命予後の改善が期待できる疾患である.▽現時点ではCAEBVに対する公費補助制度として小児慢性特定疾病のみ申請が可能だが,若年成人でも多く発症があり指定難病として認定されることが望ましい.

  • 【公費補助制度を使いこなす!】慢性活動性EBウイルス病

    矢田 裕太郎, 石村 匡崇, 大賀 正一

    小児科診療   87 ( 8 )   1060 - 1063   2024年8月   ISSN:0386-9806

     詳細を見る

    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    <文献概要>▽慢性活動性EBウイルス病(CAEBV)はその発症メカニズムがいまだ不明な難治性致死性疾患である.▽CAEBVは造血細胞移植を含む適切な治療によって,生命予後の改善が期待できる疾患である.▽現時点ではCAEBVに対する公費補助制度として小児慢性特定疾病のみ申請が可能だが,若年成人でも多く発症があり指定難病として認定されることが望ましい.

    researchmap

  • 胚中心B細胞のポジティブセレクションにおけるカルシウムシグナル

    矢田 裕太郎, 馬場 義裕

    臨床免疫・アレルギー科   81 ( 5 )   491 - 496   2024年5月   ISSN:1881-1930

     詳細を見る

    記述言語:日本語   出版者・発行元:(有)科学評論社  

  • 小児の鉄代謝 6 鉄過剰症

    矢田裕太郎, 江口克秀, 石村匡崇, 落合正行, 大賀正一

    小児科   65 ( 9 )   2024年   ISSN:0037-4121

     詳細を見る

共同研究・競争的資金等の研究課題

  • 胚中心における自己反応性B細胞のネガティブセレクションの機序解明

    研究課題/領域番号:25K18839  2025年4月 - 2028年3月

    若手研究

      詳細を見る

    資金種別:科研費

  • 胚中心における自己反応性B細胞のネガティブセレクションの機序解明

    2024年12月 - 2025年12月

    公益財団法人持田記念医学薬学振興財団  2024年度研究助成金 

      詳細を見る

    担当区分:研究代表者  資金種別:寄附金

指導学生の受賞

  • 第53回日本免疫学会学術集会 ベストプレゼンテーション賞

    授与年月:2024年12月

    受賞学生の区分:修士   受賞学生氏名:伊藤 鈴華

      詳細を見る

医師免許取得年

  • 2012年