UEZUMI AKIYOSHI
Organization
Medical Institute of Bioregulation Medical Research Center for High Depth Omics Professor
Graduate School of Medical Sciences Department of Medical Sciences（Joint Appointment）
Graduate School of Medical Sciences Department of Medicine（Joint Appointment）
Title
Professor
Contact information
Tel
0926426803
Profile
生命科学・医学の基礎研究および教育
External link
Degree
-
Ph.D.
Research Interests・Research Keywords
-
Research theme：Mechanisms underlying skeletal muscle integrity, Biological significance of mesenchymal stromal cell heterogeneity
Keyword：Skeletal muscle, Mesenchymal stromal cells, Sarcopenia, Muscle regeneration, Stem cells
Research period： 2010.1
Papers
-
Lack of vitamin D signaling in mesenchymal progenitors causes fatty infiltration in muscle Invited Reviewed International journal
Hosoyama T, Kawai-Takaishi M, Iida H, Yamamoto Y, Nakamichi Y, Watanabe T, Takemura M, Kato S, Uezumi A, Matsui Y
J Cachexia Sarcopenia Muscle 2024.5
-
Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells. International journal
Lidan Zhang, Hayato Saito, Tatsuyoshi Higashimoto, Takayuki Kaji, Ayasa Nakamura, Kanako Iwamori, Ryoko Nagano, Daisuke Motooka, Daisuke Okuzaki, Akiyoshi Uezumi, Shigeto Seno, So-Ichiro Fukada
Cell reports 43 ( 4 ) 114052 - 114052 2024.4
-
The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice.
Hiroshi Sakai, Hideaki Uno, Harumi Yamakawa, Kaori Tanaka, Aoi Ikedo, Akiyoshi Uezumi, Yasuyuki Ohkawa, Yuuki Imai
2023.11
-
Transcriptome analysis of mesenchymal stromal cells of the large and small intestinal smooth muscle layers reveals a unique gastrontestinal stromal signature. International journal
Takashi Chaen, Tamaki Kurosawa, Kazuhisa Kishi, Noriyuki Kaji, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, Masatoshi Hori
Biochemistry and biophysics reports 34 101478 - 101478 2023.7
-
Adipose tissue boosts muscle regeneration by supplying mesenchymal stromal cells. International journal
Akiyoshi Uezumi
Nature reviews. Endocrinology 19 ( 6 ) 317 - 318 2023.6
-
Roles and heterogeneity of mesenchymal progenitors in muscle homeostasis, hypertrophy, and disease. International journal
So-Ichiro Fukada, Akiyoshi Uezumi
Stem cells (Dayton, Ohio) 2023.3
-
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration. International journal
Allah Nawaz, Muhammad Bilal, Shiho Fujisaka, Tomonobu Kado, Muhammad Rahil Aslam, Saeed Ahmed, Keisuke Okabe, Yoshiko Igarashi, Yoshiyuki Watanabe, Takahide Kuwano, Koichi Tsuneyama, Ayumi Nishimura, Yasuhiro Nishida, Seiji Yamamoto, Masakiyo Sasahara, Johji Imura, Hisashi Mori, Martin M Matzuk, Fujimi Kudo, Ichiro Manabe, Akiyoshi Uezumi, Takashi Nakagawa, Yumiko Oishi, Kazuyuki Tobe
Nature communications 13 ( 1 ) 7058 - 7058 2022.11
-
Whole-mount immunofluorescence staining of mesenchymal progenitors in murine plantaris muscle. International journal
Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Akihiro Kaneshige, So-Ichiro Fukada, Akiyoshi Uezumi
STAR protocols 3 ( 3 ) 101593 - 101593 2022.9
-
Detection of muscle stem cell-derived myonuclei in murine overloaded muscles. International journal
Akihiro Kaneshige, Takayuki Kaji, Hayato Saito, Tatsuyoshi Higashimoto, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, So-Ichiro Fukada
STAR protocols 3 ( 2 ) 101307 - 101307 2022.6
-
Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. International journal
Madoka Ikemoto-Uezumi, Heying Zhou, Tamaki Kurosawa, Yuki Yoshimoto, Masashi Toyoda, Nobuo Kanazawa, Tatsu Nakazawa, Mitsuhiro Morita, Kunihiro Tsuchida, Akiyoshi Uezumi
Aging cell 21 ( 1 ) e13536 2022.1
-
Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load
Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-ichiro Fukada
Cell Stem Cell 2021.12
-
Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice
Stem Cell Research & Therapy 12 ( 1 ) 2021.12
-
Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice. International journal
Keitaro Minato, Yuki Yoshimoto, Tamaki Kurosawa, Kei Watanabe, Hiroyuki Kawashima, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi
International journal of molecular sciences 22 ( 22 ) 2021.11
-
Transgenic Expression of Bmp3b in Mesenchymal Progenitors Mitigates Age-Related Muscle Mass Loss and Neuromuscular Junction Degeneration. International journal
Tamaki Kurosawa, Keitaro Minato, Madoka Ikemoto-Uezumi, Jun Hino, Kunihiro Tsuchida, Akiyoshi Uezumi
International journal of molecular sciences 22 ( 19 ) 2021.9
-
Dlk1 regulates quiescence in calcitonin receptor-mutant muscle stem cells. International journal
Lidan Zhang, Manami Kubota, Ayasa Nakamura, Takayuki Kaji, Shigeto Seno, Akiyoshi Uezumi, Ditte Caroline Andersen, Charlotte Harken Jensen, So-Ichiro Fukada
Stem cells (Dayton, Ohio) 39 ( 3 ) 306 - 317 2021.3
-
Retinoic Acid Receptor Agonists Suppress Muscle Fatty Infiltration in Mice. International journal
Hideyuki Shirasawa, Noboru Matsumura, Masaki Yoda, Kazumasa Okubo, Masayuki Shimoda, Akiyoshi Uezumi, Morio Matsumoto, Masaya Nakamura, Keisuke Horiuchi
The American journal of sports medicine 49 ( 2 ) 332 - 339 2021.2
-
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia. International journal
Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Heying Zhou, Tamaki Kurosawa, Yuki Yoshimoto, Masashi Nakatani, Keisuke Hitachi, Hisateru Yamaguchi, Shuji Wakatsuki, Toshiyuki Araki, Mitsuhiro Morita, Harumoto Yamada, Masashi Toyoda, Nobuo Kanazawa, Tatsu Nakazawa, Jun Hino, So-Ichiro Fukada, Kunihiro Tsuchida
The Journal of clinical investigation 131 ( 1 ) 2021.1
-
Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNFα. International journal
12 ( 1 ) 11 - 11 2021.1
-
Desloratadine inhibits heterotopic ossification by suppression of BMP2-Smad1/5/8 signaling. Reviewed International journal
Taiki Kusano, Masashi Nakatani, Naoki Ishiguro, Kinji Ohno, Naoki Yamamoto, Mitsuhiro Morita, Harumoto Yamada, Akiyoshi Uezumi, Kunihiro Tsuchida
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 39 ( 6 ) 1297 - 1304 2020.2
Presentations
-
間葉系間質細胞の不均一性が支える骨格筋維持メカニズム Invited
上住 聡芳
第71回 日本職業・災害医学会学術大会 2023.12
-
間葉系間質細胞学の夜明け Invited
上住 聡芳
第96回日本生化学会大会 2023.11
-
Heterogeneity of mesenchymal stromal cells underlying skeletal muscle integrity Invited International conference
Akiyoshi Uezumi
The 18th international Symposium of the institute Network for Biomedical Science 2023.10
-
間葉系間質細胞による骨格筋維持機構 Invited
上住 聡芳
第22回運動器科学研究会 2023.9
-
間葉系間質細胞の不均一性から紐解く骨格筋の恒常性維持機構 Invited
上住 聡芳
第９回日本筋学会学術集会 2023.8
-
間葉系間質細胞の不均一性から紐解く骨格筋老化のメカニズム Invited
上住 聡芳
第75回 日本細胞生物学会大会 2023.6
-
Mechanisms coupling muscle regeneration and inflammation resolution Invited International conference
Akiyoshi Uezumi
1st Symposium on "Skeletal muscle cells in Growth and Disease" 2023.5
-
間葉系間質細胞の生理的役割解明に向けて Invited
上住 聡芳
2023.2
MISC
-
骨格筋制御メカニズムの最前線
青木 吉嗣, 上住 聡芳, 二川 健, 深田 宗一朗
骨・軟骨・筋科学Update 2024.5
-
間葉系間質細胞による骨格筋組織の健全性維持機構
上住 聡芳
生化学 2023.12
-
サルコペニアの発症機序
上住 円，上住 聡芳
別冊・医学のあゆみ 2023.10
-
Adipose tissue boosts muscle regeneration by supplying mesenchymal stromal cells
Uezumi A
Nat Rev Endocrinol 2023.3
-
Roles and Heterogeneity of Mesenchymal Progenitors in Muscle Homeostasis, Hypertrophy, and Disease Reviewed
Fukada SI, Uezumi A
Stem Cells 2023.3
Professional Memberships
-
The Molecular Biology Society of Japan
-
Japan Muscle Society
-
The Japanese Society for Regenerative Medicine
Academic Activities
-
Frontiers in Cell and Developmental Biology International contribution
2016.1 - Present
Research Projects
-
疾患モデルを駆使した筋ジストロフィーの治療法開発
2023.4 - 2026.3
受託研究
Authorship：Coinvestigator(s) Grant type：Other funds from industry-academia collaboration
-
筋ジストロフィー治療のための間葉系前駆細胞制御法開発
2023.4 - 2026.3
Authorship：Coinvestigator(s)
-
骨格筋の老化を防ぐ運動-間質連関機構の解明
Grant number：23H00456 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(A)
Authorship：Principal investigator Grant type：Scientific research funding
-
結合組織の臓器特異性から紐解くサルコペニアのメカニズム
Grant number：23K18433 2023 - 2024
日本学術振興会 科学研究費助成事業 挑戦的研究（萌芽）
Authorship：Principal investigator Grant type：Scientific research funding
-
間葉系間質細胞の局在依存的特性による筋維持機構の解明
2022.10 - 2026.3
Authorship：Principal investigator
-
間葉系間質細胞の局在依存的特性による筋維持機構の解明
2022 - 2025
戦略的創造研究推進事業 (文部科学省)
Authorship：Principal investigator Grant type：Contract research
-
小林財団研究助成
2022
Grant type：Donation
-
中外創薬科学財団研究助成金A
2022
Grant type：Donation
-
三菱財団自然科学研究助成
2022
Grant type：Donation
-
骨格筋が運動刺激を感知する新規メカニズム
Grant number：21K19753 2021 - 2023
日本学術振興会 科学研究費助成事業 挑戦的研究（萌芽）
Authorship：Principal investigator Grant type：Scientific research funding
-
筋ジストロフィー治療のための間葉系前駆細胞制御法開発
2020.4 - 2023.3
受託研究
Authorship：Coinvestigator(s) Grant type：Other funds from industry-academia collaboration
-
間葉系間質細胞の運命制御機構解明 International coauthorship
2020.1
九州大学（日本）
Authorship：Principal investigator
-
筋再生システムの老化を若返らせる分子機構
Grant number：19H04063 2019 - 2023
日本学術振興会 科学研究費助成事業 基盤研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
Class subject
-
系統生命科学II：生体情報機能学I
2023.10 - 2024.3 Second semester
-
総合医学I・総合生命科学I「生命医科学研究入門」
2023.10 - 2024.3 Second semester
Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.
-
2023 徳島大学医学部 Classification:Part-time lecturer Domestic/International Classification:Japan
-
2023 東北大学医学部 Classification:Part-time lecturer Domestic/International Classification:Japan
-
2023 国立精神・神経医療研究センター神経研究所 Classification:Affiliate faculty Domestic/International Classification:Japan