Updated on 2024/07/28

Information

 

写真a

 
OHKAWA YASUYUKI
 
Organization
Medical Institute of Bioregulation Medical Research Center for High Depth Omics Professor
Medical Institute of Bioregulation Medical Research Center for High Depth Omics(Concurrent)
Graduate School of Systems Life Sciences Department of Systems Life Sciences(Concurrent)
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
Graduate School of Pharmaceutical Sciences Department of Medicinal Sciences(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0926424534
Profile
生体防御医学研究所附属トランスオミクス医学研究センターに所属し、トランスクリプトミクス分野を主宰している。クロマチン、エピゲノム、そしてトランスクリプトミクス研究分野の関連の研究教育活動を行っている。

Degree

  • Ph.D.

Research Interests・Research Keywords

  • Research theme:Development of epigenomic/trascriptomic technology

    Keyword:epigenome transcriptome technology

    Research period: 2016.10

  • Research theme:Analysis of selective gene expression in organogenesis

    Keyword:epigenetics chromatin deep sequencer epigenome transcriptome

    Research period: 2011.8 - 2021.3

  • Research theme:Epigenetics Analysis in Stem Cell biology

    Keyword:epigenetics chromatin deep sequencer epigenome transcriptome

    Research period: 2011.8 - 2016.3

Awards

  • 令和5年度科学技術分野の文部科学大臣表彰科学技術賞

    2023.4   文部科学省   「高感度エピゲノム解析による遺伝子発現制御機構の研究」

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    発生、分化や脱分化、あるいは、がんを含む疾病のメカニズムの理解には、起点となる細胞を同定し、細胞における遺伝子発現制御を理解することは、医学生物学分野において不可欠である。一方で、組織内に存在するごく少数の幹細胞や病因となる細胞を対象としたトランスクリプトーム解析やエピゲノム解析を行う手法の開発は極めて困難であった。
    本研究は、少数細胞および単一細胞レベルのトランスクリプトーム・エピゲノム解析技術を確立し、これら技術を駆使して骨格筋幹細胞のエピゲノム制御機構を明らかにした。

  • 手島精一記念研究賞

    2020.2   東京工業大学  

  • 研究活動表彰

    2016.11   国立大学法人 九州大学  

  • 研究活動表彰

    2015.11   国立大学法人 九州大学  

  • 研究活動表彰

    2014.11   九州大学  

  • 平成25年度科学技術分野の文部科学大臣表彰 若手科学者賞

    2013.4   文部科学省   骨格筋分化を制御する高次クロマチン構造変換機構の研究

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Papers

  • Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure. Reviewed International journal

    Masahiro Oka, Mayumi Otani, Yoichi Miyamoto, Rieko Oshima, Jun Adachi, Takeshi Tomonaga, Munehiro Asally, Yuya Nagaoka, Kaori Tanaka, Atsushi Toyoda, Kazuki Ichikawa, Shinichi Morishita, Kyoichi Isono, Haruhiko Koseki, Ryuichiro Nakato, Yasuyuki Ohkawa, Yoshihiro Yoneda

    Cell reports   42 ( 8 )   112884 - 112884   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2023.112884

  • Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Reviewed International journal

    Nature   163 ( 7942 )   169 - 178   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41586-022-05535-x.

    Other Link: https://www.nature.com/articles/s41586-022-05535-x

  • Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections. Reviewed International journal

    Mizuki Honda, Ryuichi Kimura, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Yasuyuki Ohkawa, Shinya Oki.

    STAR Protoc.   3 ( 2 )   101346   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.xpro.2022.

    Other Link: https://www.sciencedirect.com/science/article/pii/S266616672200226X?via%3Dihub

  • Modeling population size independent tissue epigenomes by ChIL-seq with single thin sections Reviewed International journal

    Kazumitsu Maehara, Kosuke Tomimatsu, Akihito Harada, Kaori Tanaka, Shoko Sato, Megumi Fukuoka, Seiji Okada, Tetsuya Handa, Hitoshi Kurumizaka, Noriko Saitoh, Hiroshi Kimura, and Yasuyuki Ohkawa*

    Molecular Systems Biology   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • High-depth spatial transcriptome analysis by photo-isolation chemistry. Reviewed International journal

    Nature Communications   12 ( 1 )   4416   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-021-24691-8

  • Modeling population size independent tissue epigenomes by ChIL-seq with single-thin sections Reviewed International journal

    Kazumitsu Maehara, Kosuke Tomimatsu, Akihito Harada, Kaori Tanaka, Shoko Sato, Seiji Okada, Tetsuya Handa, Hitoshi Kurumizaka, Hiroshi Kimura, Yasuyuki Ohkawa

    Mol Syst Biol.   2020.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1101/2020.12.18.423434

  • Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input. Reviewed International journal

    Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura

    Nature protocols   15 ( 10 )   3334 - 3360   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41596-020-0375-8

  • A chromatin integration labelling method enables epigenomic profiling with lower input Reviewed

    Akihito Harada, Kazumitsu Maehara, Tetsuya Handa, Yasuhiro Arimura, Jumpei Nogami, Yoko Hayashi-Takanaka, Katsuhiko Shirahige, Hitoshi Kurumizaka, Hiroshi Kimura, Yasuyuki Ohkawa

    Nature Cell Biology   21 ( 2 )   287 - 296   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41556-018-0248-3

  • Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration Reviewed

    Akihito Harada, Kazumitsu Maehara, Yusuke Ono, Hiroyuki Taguchi, Kiyoshi Yoshioka, Yasuo Kitajima, Yan Xie, Yuko Sato, Takeshi Iwasaki, Jumpei Nogami, Seiji Okada, Tetsuro Komatsu, Yuichiro Semba, Tatsuya Takemoto, Hiroshi Kimura, Hitoshi Kurumizaka, Yasuyuki Ohkawa

    Nature Communications   9 ( 1 )   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-03845-1

  • Sensitive detection of fluorescence in western blotting by merging images Reviewed

    Yukari Kondo, Shinichiro Higa, Takeshi Iwasaki, Tomoya Matsumoto, Kazumitsu Maehara, Akihito Harada, Yoshihiro Baba, Masatoshi Fujita, Yasuyuki Ohkawa

    PLoS One   13 ( 1 )   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0191532

  • Temporal regulation of chromatin during myoblast differentiation Reviewed International journal

    Akihito Harada, Yasuyuki Ohkawa, Anthony N. Imbalzano

    Seminars in Cell and Developmental Biology   72   77 - 86   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.semcdb.2017.10.022

  • Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells Reviewed

    Yuichiro Semba, Akihito Harada, Kazumitsu Maehara, Shinya Oki, Chikara Meno, Jun Ueda, Kazuo Yamagata, Atsushi Suzuki, Mitsuho Onimaru, Jumpei Nogami, Seiji Okada, Koichi Akashi, Yasuyuki Ohkawa

    Nucleic Acids Research   45 ( 15 )   8758 - 8772   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkx475

  • The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation. Reviewed International journal

    Kensuke Kudou, Tetsuro Komatsu, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Yasuyuki Ohkawa

    Open biology   7 ( 9 )   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1098/rsob.170119

  • Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Reviewed

    Hiroyuki Taguchi, Yan Xie, Naoki Horikoshi, Kazumitsu Maehara, Akihito Harada, Jumpei Nogami, Koichi Sato, Yasuhiro Arimura, Akihisa Osakabe, Tomoya Kujirai, Takeshi Iwasaki, Yuichiro Semba, Taro Tachibana, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Biochemistry   56 ( 16 )   2184 - 2196   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.biochem.6b01098

  • Crystal structure of the overlapping dinucleosome composed of hexasome and octasome Reviewed

    Daiki Kato, Akihisa Osakabe, Yasuhiro Arimura, Yuka Mizukami, Naoki Horikoshi, Kazumi Saikusa, Satoko Akashi, Yoshifumi Nishimura, Sam Yong Park, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Atsushi Matsumoto, Hidetoshi Kono, Rintaro Inoue, Masaaki Sugiyama, Hitoshi Kurumizaka

    Science   356 ( 6334 )   205 - 208   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.aak9867

  • Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis Reviewed

    Jun Ueda, Akihito Harada, Takashi Urahama, Shinichi Machida, Kazumitsu Maehara, Masashi Hada, Yoshinori Makino, Jumpei Nogami, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroki Tanaka, Hiroaki Tachiwana, Tatsuma Yao, Minami Yamada, Takashi Iwamoto, Ayako Isotani, Masahito Ikawa, Taro Tachibana, Yuki Okada, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Kazuo Yamagata

    Cell Reports   18 ( 3 )   593 - 600   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2016.12.065

  • The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation Reviewed

    Kensuke Kudou, Tetsuro Komatsu, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Yasuyuki Ohkawa

    Open Biology   7 ( 9 )   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1098/rsob.170119

  • Identification of immunoglobulin gene sequences from a small read number of mRNA-seq using hybridomas Reviewed

    Yuki Kuniyoshi, Kazumitsu Maehara, Takeshi Iwasaki, Masayasu Hayashi, Yuichiro Semba, Masatoshi Fujita, Yuko Sato, Hiroshi Kimura, Akihito Harada, Yasuyuki Ohkawa

    PLoS One   11 ( 10 )   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0165473

  • Tissue-specific expression of histone H3 variants diversified after species separation Reviewed

    Kazumitsu Maehara, Akihito Harada, Yuko Sato, Masaki Matsumoto, Keiichi Nakayama, Hiroshi Kimura, Yasuyuki Ohkawa

    Epigenetics and Chromatin   8 ( 1 )   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13072-015-0027-3

  • Spatial re-organization of myogenic regulatory sequences temporally controls gene expression Reviewed

    Akihito Harada, Chandrashekara Mallappa, Seiji Okada, John T. Butler, Stephen P. Baker, Jeanne B. Lawrence, Yasuyuki Ohkawa, Anthony N. Imbalzano

    Nucleic Acids Research   43 ( 4 )   2008 - 2021   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkv046

  • Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle Reviewed

    Akihito Harada, Kazumitsu Maehara, Yuko Sato, Daijiro Konno, Taro Tachibana, Hiroshi Kimura, Yasuyuki Ohkawa

    Nucleic Acids Research   43 ( 2 )   775 - 786   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gku1346

  • A co-localization model of paired ChIP-seq data using a large ENCODE data set enables comparison of multiple samples Reviewed

    Kazumitsu Maehara, Jun Odawara, Akihito Harada, Tomohiko Yoshimi, Koji Nagao, Chikashi Obuse, Koichi Akashi, Taro Tachibana, Toshio Sakata, Yasuyuki Ohkawa

    Nucleic Acids Research   41 ( 1 )   54 - 62   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gks1010

  • Chd2 interacts with H3.3 to determine myogenic cell fate Reviewed

    Akihito Harada, Seiji Okada, Daijiro Konno, Jun Odawara, Tomohiko Yoshimi, Saori Yoshimura, Hiromi Kumamaru, Hirokazu Saiwai, Toshiaki Tsubota, Hitoshi Kurumizaka, Koichi Akashi, Taro Tachibana, Anthony N. Imbalzano, Yasuyuki Ohkawa

    EMBO Journal   31 ( 13 )   2994 - 3007   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/emboj.2012.136

  • Production of a Monoclonal Antibody for Histone H2b Isoform H2b3b. Reviewed International journal

    Egashira S, Tachibana T, Nakamura M, Ohkawa Y, Harada A.

    Monoclon Antib Immunodiagn Immunother,   43 ( 2 )   75 - 80   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/mab.2023.0025.

  • Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility. Reviewed International journal

    Ishii S, Kakizuka T, Park SJ, Tagawa A, Sanbo C, Tanabe H, Ohkawa Y, Nakanishi M, Nakai K, Miyanari Y.

    Nat Genet.   56 ( 3 )   473 - 482   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41588-024-01658-1.

  • Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties. Reviewed International journal

    Nishimura M, Fujii T, Tanaka H, Maehara K, Morishima K, Shimizu M, Kobayashi Y, Nozawa K, Takizawa Y, Sugiyama M, Ohkawa Y, Kurumizaka H.

    Commun Biol.   7 ( 1 )   61   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-023-05694-1

  • Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.8. Reviewed International journal

    Hirai S, Kujirai T, Akatsu M, Ogasawara M, Ehara H, Sekine SI, Ohkawa Y, Takizawa Y, Kurumizaka H.

    J Biochem.   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvad069.

  • FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation Reviewed International journal

    Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama

    Cell Reports   42 ( 5 )   112530 - 112530   2023.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2023.112530

  • Design and implementation of a hybrid cloud system for large-scale human genomic research. Reviewed International journal

    Masao Nagasaki, Yayoi Sekiya, Akihiro Asakura, Ryo Teraoka, Ryoko Otokozawa, Hiroki Hashimoto, Takahisa Kawaguchi, Keiichiro Fukazawa, Yuichi Inadomi, Ken T Murata, Yasuyuki Ohkawa, Izumi Yamaguchi, Takamichi Mizuhara, Katsushi Tokunaga, Yuji Sekiya, Toshihiro Hanawa, Ryo Yamada, Fumihiko Matsuda.

    Hum Genome Var.   10 ( 1 )   6   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41439-023-00231-2.

    Other Link: https://www.nature.com/articles/s41439-023-00231-2

  • STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity. Reviewed International journal

    Hiroaki Ohishi, Seiru Shimada, Satoshi Uchino, Jieru Li, Yuko Sato, Manabu Shintani, Hitoshi Owada, Yasuyuki Ohkawa, Alexandros Pertsinidis, Takashi Yamamoto, Hiroshi Kimura, Hiroshi Ochiai.

    Nat Commun.   13 ( 1 )   7672   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41467-022-35286-2.

    Other Link: https://www.nature.com/articles/s41467-022-35286-2

  • Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka. Reviewed International journal

    Thomas Fleming, Yukiko Kikuchi, Mikoto Nakajo, Masaya Tachizawa, Tomoaki Inazumi, Soken Tsuchiya, Yukihiko Sugimoto, Daisuke Saito, Mikita Suyama, Yasuyuki Ohkawa, Takashi Baba, Ken-Ichirou Morohashi, Kataaki Okubo

    Commun Biol.   5 ( 1 )   1215   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s42003-022-04195-x.

    Other Link: https://www.nature.com/articles/s42003-022-04195-x

  • Drosophila transcription factor NF-Y suppresses transcription of the lipase 4 gene, a key gene for lipid storage. Invited Reviewed International journal

    Yasuhide Yoshioka, Keisuke Anzai, Ryosuke Kowada, Ken Hiratsuka, Teppei Hirayabu, Masashi Yasuda, Yasuyuki Ohkawa, Tetsuya Sato, Mikita Suyama, Hideki Yoshida, Masamitsu Yamaguchi

    Exp Cell Res.   420 ( 1 )   113307   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.yexcr.2022.113307.

  • Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway Reviewed International journal

    Miki Inoue, Takashi Baba, Fumiya Takahashi, Miho Terao, Shogo Yanai, Yuichi Shima, Daisuke Saito, Kei Sugihara, Takashi Miura, Shuji Takada, Mikita Suyama, Yasuyuki Ohkawa, Ken-Ichirou Morohashi

    Commun Biol.   5 ( 1 )   974   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s42003-022-03941-5.

    Other Link: https://www.nature.com/articles/s42003-022-03941-5

  • Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing. Reviewed International journal

    Toru Masuda, Shojiro Haji, Yasuhiro Nakashima, Mariko Tsuda, Daisaku Kimura, Akiko Takamatsu, Norifusa Iwahashi, Hironobu Umakoshi, Motoaki Shiratsuchi, Chie Kikutake, Mikita Suyama, Yasuyuki Ohkawa, Yoshihiro Ogawa

    iScience   25 ( 8 )   104781   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.isci.2022.104781.

  • A spinal microglia population involved in remitting and relapsing neuropathic pain Reviewed International journal

    Keita Kohno, Ryoji Shirasaka, Kohei Yoshihara, Satsuki Mikuriya, Kaori Tanaka, Keiko Takanami, Kazuhide Inoue, Hirotaka Sakamoto, Yasuyuki Ohkawa, Takahiro Masuda, Makoto Tsuda.

    Science   376 ( 6588 )   86 - 90   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.abf6805.

  • Uterus-specific transcriptional regulation underlies eggshell pigment production in Japanese quail. Reviewed International journal

    Satoshi Ishishita, Shumpei Kitahara, Mayuko Takahashi, Sakura Iwasaki, Shoji Tatsumoto, Izumi Hara, Yoshiki Kaneko, Keiji Kinoshita, Katsushi Yamaguchi, Akihito Harada, Yasushige Ohmori, Yasuyuki Ohkawa, Yasuhiro Go, Shuji Shigenobu, Yoichi Matsuda, Takayuki Suzuki.

    PLoS One   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep4.1911.

  • Uhrf1 governs the proliferation and differentiation of muscle satellite cells Reviewed

    Hiroshi Sakai, Yuichiro Sawada, Naohito Tokunaga, Kaori Tanaka, So Nakagawa, Iori Sakakibara, Yusuke Ono, So-ichiro Fukada, Yasuyuki Ohkawa, Tadahiko Kikugawa, Takashi Saika, Yuuki Imai

    iScience   25 ( 3 )   103928 - 103928   2022.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2022.103928

  • Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation. Reviewed International journal

    Yuki Yoshimoto, Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Kaori Tanaka, Xinyi Yu, Tamaki Kurosawa, Shinsei Yambe, Kazumitsu Maehara, Yasuyuki Ohkawa, Yusuke Sotomaru, Chisa Shukunami.

    Front Cell Dev Biol.   10   780038   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fcell.2022.780038.

    Other Link: https://www.frontiersin.org/articles/10.3389/fcell.2022.780038/full

  • Direct Conversion of Human Endothelial Cells Into Liver Cancer-Forming Cells Using Nonintegrative Episomal Vectors. Reviewed International journal

    Takeshi Goya, Kenichi Horisawa, Miyako Udono, Yasuyuki Ohkawa, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki.

    Hepatol Commun   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep4.1911.

  • Live imaging of transcription sites using an elongating RNA polymerase II-specific probe. Reviewed International journal

    J Cell Biol   221 ( 2 )   e202104134   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1083/jcb.202104134.

  • Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load. Reviewed International journal

    Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada

    Cell Stem Cell   29 ( 2 )   265 - 280.e6.   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stem.2021.11.003.

  • Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant. Reviewed International journal

    Seiya Hirai, Kosuke Tomimatsu, Atsuko Miyawaki-Kuwakado, Yoshimasa Takizawa, Tetsuro Komatsu, Taro Tachibana, Yutaro Fukushima, Yasuko Takeda, Lumi Negishi, Tomoya Kujirai, Masako Koyama, Yasuyuki Ohkawa, Hitoshi Kurumizaka.

    Nucleic Acids Res   50 ( 1 )   72 - 91   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkab1137.

  • Totipotency of mouse zygotes extends to single blastomeres of embryos at the four-cell stage Reviewed International journal

    Marino Maemura, Hiroaki Taketsuru, Yuki Nakajima, Ruiqi Shao, Ayaka Kakihara, Jumpei Nogami, Yasuyuki Ohkawa, Yu-ichi Tsukada

    Scientific Reports   11 ( 1 )   2021.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-90653-1

  • High-throughput single-cell epigenomic profiling by targeted insertion of promoters (TIP-seq) Reviewed International journal

    Daniel A Bartlett, Vishnu Dileep, Tetsuya Handa, Yasuyuki Ohkawa, Hiroshi Kimura, Steven Henikoff, David M Gilbert.

    J Cell Biol   220 ( 12 )   e202103078   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1083/jcb.202103078.

  • Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry. Reviewed International journal

    Yoko Hayashi-Takanaka, Yuichiro Hayashi, Yasuhiro Hirano, Atsuko Miyawaki-Kuwakado, Yasuyuki Ohkawa, Chikashi Obuse, Hiroshi Kimura, Tokuko Haraguchi, Yasushi Hiraoka.

    Nucleic Acids Res   49 ( 21 )   12152 - 12166   2021.12

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    DOI: 10.1093/nar/gkab1068.

  • Recent advances in single-cell epigenomics. Reviewed International journal

    Akihito Harada, Hiroshi Kimura, Yasuyuki Ohkawa.

    Curr Opin Struct Bio   116 - 122   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.sbi.2021.06.010.

  • Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle. Reviewed International journal

    Antonius Christianto, Takashi Baba, Fumiya Takahashi, Kai Inui, Miki Inoue, Mikita Suyama, Yusuke Ono, Yasuyuki Ohkawa, Ken-Ichirou Morohashi

    Communications biology   4 ( 1 )   1264 - 1264   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-021-02790-y

  • Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development. Reviewed International journal

    Sayako Katada, Jun Takouda, Takumi Nakagawa, Mizuki Honda, Katsuhide Igarashi, Takuya Imamura, Yasuyuki Ohkawa, Shoko Sato, Hitoshi Kurumizaka, Kinichi Nakashima

    Genes & development   35 ( 21-22 )   1431 - 1444   2021.11

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    DOI: 10.1101/gad.348797.121

  • Discriminative feature of cells characterizes cell populations of interest by a small subset of genes. Reviewed International journal

    Takeru Fujii, Kazumitsu Maehara, Masatoshi Fujita, Yasuyuki Ohkawa.

    PLoS Comput Biol   17 ( 11 )   e1009579   2021.11

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    DOI: 10.1371/journal.pcbi.1009579.

  • Integrated Analysis of Transcriptome and Histone Modifications in Granulosa Cells During Ovulation in Female Mice Reviewed International journal

    Yuichiro Shirafuta, Isao Tamura, Yasuyuki Ohkawa, Ryo Maekawa, Yumiko Doi-Tanaka, Haruka Takagi, Yumiko Mihara, Masahiro Shinagawa, Toshiaki Taketani, Shun Sato, Hiroshi Tamura, Norihiro Sugino

    Endocrinology   2 ( 9 )   bqab128   2021.9

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    DOI: 10.1210/endocr/bqab128.

  • An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver Reviewed International journal

    Fumiko Matsuzaki, Shinsuke Uda, Yukiyo Yamauchi, Masaki Matsumoto, Tomoyoshi Soga, Kazumitsu Maehara, Yasuyuki Ohkawa, Keiichi I Nakayama, Shinya Kuroda, Hiroyuki Kubota.

    Cell Reports   36 ( 8 )   109569   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2021

  • Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells Reviewed International journal

    Hiroshi Ochiai, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Akihito Harada, Yukiko Shimizu, Kenta Nakano, Noriko Saitoh, Zhe Liu, Takashi Yamamoto, Tadashi Okamura, Yasuyuki Ohkawa, Hiroshi Kimura, Itoshi Nikaido

    SCIENCE ADVANCES   6 ( 25 )   2021.6

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    DOI: 10.1126/sciadv.aaz6699

  • Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. Reviewed International journal

    Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono.

    Science Advances   7 ( 24 )   eabd7924   2021.6

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    DOI: 10.1126/sciadv.abd7924

  • Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay Reviewed International journal

    Hiroaki Tachiwana, Mariko Dacher, Kazumitsu Maehara, Akihito Harada, Yosuke Seto, Ryohei Katayama, Yasuyuki Ohkawa, Hiroshi Kimura, Hitoshi Kurumizaka, Noriko Saitoh

    ELIFE   10   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.66290

  • Totipotency of mouse zygotes extends to single blastomeres of embryos at the four-cell stage. Reviewed International journal

    Marino Maemura, Hiroaki Taketsuru, Yuki Nakajima, Ruiqi Shao, Ayaka Kakihara, Jumpei Nogami, Yasuyuki Ohkawa, Yu-Ichi Tsukada.

    Scientific Reports   11 ( 1 )   11167   2021.5

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  • Transcriptome analysis of gene expression changes upon enzymatic dissociation in skeletal myoblasts Reviewed International journal

    Atsuko Miyawaki-Kuwakado, Qianmei Wu, Akihito Harada, Kosuke Tomimatsu, Takeru Fujii, Kazumitsu Maehara, Yasuyuki Ohkawa.

    Genes to Cells   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12870

  • Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound Reviewed International journal

    Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui.

    The Journal of Allergy and Clinical Immunology   2021.4

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    DOI: 10.1016/j.jaci.2021.03.029

  • Visualizing transcription sites in living cells using a genetically encoded probe specific for the elongating form of RNA polymerase II

    Satoshi Uchino, Yuma Ito, Yuko Sato, Tetsuya Handa, Yasuyuki Ohkawa, Makio Tokunaga, Hiroshi Kimura

    bioRxiv   2021.4

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    DOI: 10.1101/2021.04.27.441582

  • H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing Reviewed International journal

    Journal of Biochemistry   22 ( 3 )   2021.3

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  • Gene expression and functional abnormalities in XX/Sry Leydig cells Reviewed International journal

    Shogo Yanai, Takashi Baba, Kai Inui, Kanako Miyabayashi, Soyun Han, Miki Inoue, Fumiya Takahashi, Yoshiakira Kanai, Yasuyuki Ohkawa, Man Ho Choi, Ken-Ichirou Morohashi

    SCIENTIFIC REPORTS   11 ( 1 )   719   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-80741-z

  • Genome-wide analysis of chromatin structure changes upon MyoD binding in proliferative myoblasts during the cell cycle Reviewed International journal

    Qianmei Wu, Takeru Fujii, Akihito Harada, Kosuke Tomimatsu, Atsuko Miyawaki-Kuwakado, Masatoshi Fujita, Kazumitsu Maehara, Yasuyuki Ohkawa

    Journal of Biochemistry   2021.1

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    DOI: 10.1093/jb/mvab001

  • Transcription factor C/EBPβ induces genome-wide H3K27ac and upregulates gene expression during decidualization of human endometrial stromal cells Reviewed International journal

    520   111085   2021.1

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    We previously reported that H3K27 acetylation (H3K27ac) increases throughout the genome during decidualization of human endometrial stromal cells (ESCs). However, its mechanisms have not been clarified. We also reported that C/EBPβ acts as a pioneer factor initiating chromatin remodeling by increasing H3K27ac of IGFBP-1 and PRL promoters. Therefore, C/EBPβ may be involved in the genome-wide increase of H3K27ac during decidualization. In this study, we investigated whether C/EBPβ causes genome-wide H3K27ac modifications and regulates gene expressions during decidualization. cAMP was used to induce decidualization. Three types of cells (control cells, cAMP-treated cells, and cAMP-treated + C/EBPβ-knockdowned cells by siRNA) were generated. Of 4190 genes that were upregulated by cAMP, C/EBPβ knockdown inhibited these upregulation in 2239 genes (53.4%), indicating that they are under the regulation of C/EBPβ. cAMP increased H3K27ac in 1272 of the 2239 genes. C/EBPβ knockdown abolished the increase of H3K27ac in almost all genes (1263 genes, 99.3%), suggesting that C/EBPβ can upregulate gene expression by increasing H3K27ac. To investigate how C/EBPβ regulates H3K27ac throughout the genome, we tested the hypothesis that C/EBPβ binds to its binding regions and recruits cofactors with histone acetyltransferase activities. To do this, we collated our ChIP-sequence data with public ChIP-sequence database of transcription factors, and found that p300 is the most likely cofactor that binds to the H3K27ac-increased-regions with C/EBPβ. ChIP-qPCR of several genes confirmed that C/EBPβ binds to the target regions, recruits p300, and increases H3K27ac. Our genome-wide analysis revealed that C/EBPβ induces H3K27ac throughout the genome and upregulates gene expressions during decidualization by recruiting p300 to the promoters.

    DOI: 10.1016/j.mce.2020.111085

  • Subnuclear gene positioning through lamina association affects copper tolerance Reviewed International journal

    Yuki Sakamoto, Mayuko Sato, Yoshikatsu Sato, Akihito Harada, Takamasa Suzuki, Chieko Goto, Kentaro Tamura, Kiminori Toyooka, Hiroshi Kimura, Yasuyuki Ohkawa, Ikuko Hara-Nishimura, Shingo Takagi, Sachihiro Matsunaga

    NATURE COMMUNICATIONS   11 ( 1 )   5914   2020.11

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    DOI: 10.1038/s41467-020-19621-z

  • Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells Reviewed International journal

    Hiroki Inada, Miyako Udono , Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki.

    NATURE COMMUNICATIONS   11 ( 1 )   5292   2020.10

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    DOI: 10.1038/s41467-020-19041-z

  • The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors Reviewed International journal

    Kenichi Horisawa, Miyako Udono, Kazuko Ueno, Yasuyuki Ohkawa, Masao Nagasaki, Sayaka Sekiya, Atsushi Suzuki.

    Molecular Cell   79 ( 4 )   660 - 676.e8   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molcel.2020.07.012

  • Tyrosine kinase inhibitors induce alternative spliced BCR-ABL Ins35bp variant via inhibition of RNA polymerase II on genomic BCR-ABL. Reviewed International journal

    Junichiro Yuda, Jun Odawara, Mariko Minami, Tsuyoshi Muta, Kentaro Kohno, Kazuki Tanimoto, Tetsuya Eto, Takahiro Shima, Yoshikane Kikushige, Koji Kato, Katsuto Takenaka, Hiromi Iwasaki, Yosuke Minami, Yasuyuki Ohkawa, Koichi Akashi, Toshihiro Miyamoto.

    Cancer Science   111 ( 7 )   2361 - 2373   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14424

  • Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells. Reviewed International journal

    Hiroshi Ochiai, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Akihito Harada, Yukiko Shimizu, Kenta Nakano, Noriko Saitoh, Zhe Liu, Takashi Yamamoto, Tadashi Okamura, Yasuyuki Ohkawa, Hiroshi Kimura, Itoshi Nikaido

    Science advances   6 ( 25 )   eaaz6699   2020.6

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    DOI: 10.1126/sciadv.aaz6699

  • Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies Through DNMT3A Exclusion Reviewed International journal

    Misuzu Kurihara , Kagayaki Kato , Chiaki Sanbo , Shuji Shigenobu , Yasuyuki Ohkawa , Takeshi Fuchigami , Yusuke Miyanari

    MOLECULAR CELL   78 ( 3 )   493 - 505   2020.5

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    DOI: 10.1016/j.molcel.2020.04.004.

  • TKIs Induce Alternative Spliced BCR-ABL Ins35bp Variant via Inhibition of RNA Polymerase Ⅱ on Genomic BCR-ABL Reviewed International journal

    2020.4

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    To elucidate dynamic changes in native BCR-ABL and alternatively spliced tyrosine kinase inhibitor (TKI)-resistant but function-dead BCR-ABLIns35bp variant, following commencement or discontinuation of TKI therapy, each transcript was serially quantified in patients with chronic myeloid leukemia (CML) by deep sequencing. Because both transcripts were amplified together using conventional PCR system for measuring International Scale (IS), deep sequencing method was used for quantifying such BCR-ABL variants. At the initial diagnosis, 7 of 9 patients presented a small fraction of cells possessing BCR-ABLIns35bp , accounting for 0.8% of the total IS BCR-ABL, corresponding to actual BCR-ABLIns35bp value of 1.1539% IS. TKI rapidly decreased native BCR-ABL but not BCR-ABLIns35bp , leading to the initial increase in the proportion of BCR-ABLIns35bp . Thereafter, both native BCR-ABL and BCR-ABLIns35bp gradually decreased in the course of TKI treatment, whereas small populations positive for TKI-resistant BCR-ABLIns35bp continued fluctuating at low levels, possibly underestimating the molecular response (MR). Following TKI discontinuation, sequencing analysis of 54 patients revealed a rapid relapse, apparently derived from native BCR-ABL+ clones. However, IS fluctuating at low levels around MR4.0 marked a predominant persistence of cells expressing function-dead BCR-ABLIns35bp , suggesting that TKI resumption was unnecessary. We clarified the possible mechanism underlying mis-splicing BCR-ABLIns35bp , occurring at the particular pseudo-splice site within intron8, which can be augmented by TKI treatment through inhibition of RNA polymerase II phosphorylation. No mutations were found in spliceosomal genes. Therefore, monitoring IS functional BCR-ABL extracting BCR-ABLIns35bp would lead us to a correct evaluation of MR status, thus determining the adequate therapeutic intervention.

    DOI: 10.1111/cas.14424.

  • The role of galanin in the differentiation of mucosal mast cells in mice Reviewed International journal

    Tomoko Yamaguchi, Yumi Ikeda, Katsuhisa Tashiro, Yasuyuki Ohkawa, Kenji Kawabata

    EUROPEAN JOURNAL OF IMMUNOLOGY   50 ( 1 )   110 - 118   2020.1

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    DOI: 10.1002/eji.201848061

  • miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation Reviewed International journal

    Takashi Kozuka, Yoshihiro Omori, Satoshi Watanabe, Etsuko Tarusawa, Haruka Yamamoto, Taro Chaya, Mayu Furuhashi, Makiko Morita, Tetsuya Sato, Shinichi Hirose, Yasuyuki Ohkawa, Yumiko Yoshimura, Takatoshi Hikida, Takahisa Furukawa

    Scientific reports   9 ( 1 )   2019.12

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    DOI: 10.1038/s41598-019-38910-2

  • The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis Reviewed International journal

    Mohamed Osama Ali Abdalla, Tatsuro Yamamoto, Kazumitsu Maehara, Jumpei Nogami, Yasuyuki Ohkawa, Hisashi Miura, Rawin Poonperm, Ichiro Hiratani, Hideki Nakayama, Mitsuyoshi Nakao, Noriko Saitoh

    Nature communications   10 ( 1 )   2019.12

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    DOI: 10.1038/s41467-019-11378-4

  • Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo Reviewed International journal

    Yuki Akieda, Shohei Ogamino, Hironobu Furuie, Shizuka Ishitani, Ryutaro Akiyoshi, Jumpei Nogami, Takamasa Masuda, Nobuyuki Shimizu, Yasuyuki Ohkawa, Tohru Ishitani

    Nature communications   10 ( 1 )   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-019-12609-4

  • Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells Reviewed International journal

    Masahiro Oka, Sonoko Mura, Mayumi Otani, Yoichi Miyamoto, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Taro Tachibana, Yoshihiro Yoneda, Yasuyuki Ohkawa

    eLife   8   2019.11

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    DOI: 10.7554/eLife.46667

  • Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI/SNF chromatin remodeling enzyme Reviewed International journal

    Hanna Witwicka, Jumpei Nogami, Sabriya A. Syed, Kazumitsu Maehara, Teresita Padilla-Benavides, Yasuyuki Ohkawa, Anthony N. Imbalzano

    Molecular and cellular biology   39 ( 19 )   2019.10

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    DOI: 10.1128/MCB.00063-19

  • Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo. Reviewed International journal

    Yuki Akieda, Shohei Ogamino, Hironobu Furuie, Shizuka Ishitani, Ryutaro Akiyoshi, Jumpei Nogami, Takamasa Masuda, Nobuyuki Shimizu, Yasuyuki Ohkawa, Tohru Ishitani

    Nature communications   10 ( 1 )   4710 - 4710   2019.10

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    DOI: 10.1038/s41467-019-12609-4

  • Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle Reviewed International journal

    Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, Yu Taro Noguchi, Yusei Takemoto, Lidan Zhang, Kazutake Tsujikawa, Hiroki Kokubo, Akiyoshi Uezumi, Kazumitsu Maehara, Akihito Harada, Yasuyuki Ohkawa, So Ichiro Fukada

    eLife   8   2019.9

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    DOI: 10.7554/eLife.48284

  • Biochemical analysis of nucleosome targeting by Tn5 transposase Reviewed International journal

    Shoko Sato, Yasuhiro Arimura, Tomoya Kujirai, Akihito Harada, Kazumitsu Maehara, Jumpei Nogami, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Open Biology   9 ( 8 )   2019.8

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    DOI: 10.1098/rsob.190116

  • The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis. Reviewed International journal

    Mohamed Osama Ali Abdalla, Tatsuro Yamamoto, Kazumitsu Maehara, Jumpei Nogami, Yasuyuki Ohkawa, Hisashi Miura, Rawin Poonperm, Ichiro Hiratani, Hideki Nakayama, Mitsuyoshi Nakao, Noriko Saitoh

    Nature communications   10 ( 1 )   3778 - 3778   2019.8

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    DOI: 10.1038/s41467-019-11378-4

  • Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes Reviewed International journal

    Daijiro Konno, Chiaki Kishida, Kazumitsu Maehara, Yasuyuki Ohkawa, Hiroshi Kiyonari, Seiji Okada, Fumio Matsuzaki

    Development (Cambridge)   146 ( 15 )   2019.8

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    DOI: 10.1242/dev.174243

  • CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors Reviewed

    Masami Miki, Takamasa Oono, Nao Fujimori, Takehiro Takaoka, Ken Kawabe, Yoshihiro Miyasaka, Takao Ohtsuka, Daisuke Saito, Masafumi Nakamura, Yasuyuki Ohkawa, Yoshinao Oda, Mikita Suyama, Tetsuhide Ito, Yoshihiro Ogawa

    Cancer Medicine   8 ( 8 )   3748 - 3760   2019.7

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    DOI: 10.1002/cam4.2232

  • Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1 Reviewed

    Masato Sorida, Takahiro Hirauchi, Hiroaki Ishizaki, Wataru Kaito, Atsushi Shimada, Chie Mori, Yuji Chikashige, Yasushi Hiraoka, Yutaka Suzuki, Yasuyuki Ohkawa, Hiroaki Kato, Shinya Takahata, Yota Murakami

    PLoS genetics   15 ( 6 )   2019.6

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    DOI: 10.1371/journal.pgen.1008129

  • Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1. Reviewed International journal

    Masato Sorida, Takahiro Hirauchi, Hiroaki Ishizaki, Wataru Kaito, Atsushi Shimada, Chie Mori, Yuji Chikashige, Yasushi Hiraoka, Yutaka Suzuki, Yasuyuki Ohkawa, Hiroaki Kato, Shinya Takahata, Yota Murakami

    PLoS genetics   15 ( 6 )   e1008129   2019.6

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    DOI: 10.1371/journal.pgen.1008129

  • Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants. Reviewed International journal

    Mayo Araki, Massanori Kurihara, Suzuko Kinoshita, Rie Awane, Tetsuya Sato, Yasuyuki Ohkawa, Yoshihiro H Inoue

    Disease models & mechanisms   12 ( 6 )   2019.6

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    DOI: 10.1242/dmm.037721

  • Macrophage centripetal migration drives spontaneous healing process after spinal cord injury Reviewed

    Kazu Kobayakawa, Yasuyuki Ohkawa, Shingo Yoshizaki, Tetsuya Tamaru, Takeyuki Saito, Ken Kijima, Kazuya Yokota, Masamitsu Hara, Kensuke Kubota, Yoshihiro Matsumoto, Katsumi Harimaya, Keiko Ozato, Takahiro Masuda, Tsuda Makoto, Tomohiko Tamura, Kazuhide Inoue, V. Reggie Edgerton, Yukihide Iwamoto, Yasuharu Nakashima, Seiji Okada

    Science Advances   5 ( 5 )   2019.5

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    DOI: 10.1126/sciadv.aav5086

  • Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing Reviewed

    Akira Matsuda, Yosuke Asada, Naomasa Suita, Satoshi Iwamoto, Toshiaki Hirakata, Norihiko Yokoi, Yasuyuki Ohkawa, Yukinori Okada, Takehiko Yokomizo, Nobuyuki Ebihara

    Journal of Allergy and Clinical Immunology   143 ( 4 )   1610 - 1614.e6   2019.4

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    DOI: 10.1016/j.jaci.2018.11.007

  • Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones Reviewed

    Yuko Katoh-Fukui, Takashi Baba, Tetsuya Sato, Hiroyuki Otake, Yuko Nagakui-Noguchi, Miyuki Shindo, Mikita Suyama, Yasuyuki Ohkawa, Hideki Tsumura, Ken-Ichirou Morohashi, Maki Fukami

    Bone   120   219 - 231   2019.3

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    DOI: 10.1016/j.bone.2018.10.021

  • Modeling latent flows on single-cell data using the Hodge decomposition

    Kazumitsu Maehara, Yasuyuki Ohkawa

    bioRxiv   2019.3

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    Modeling latent flows on single-cell data using the Hodge decomposition

    DOI: 10.1101/592089

  • Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection. Reviewed International journal

    Kazu Kobayakawa, Kyleigh Alexis DePetro, Hui Zhong, Bau Pham, Masamitsu Hara, Akihito Harada, Jumpei Nogami, Yasuyuki Ohkawa, V Reggie Edgerton

    Neurorehabilitation and neural repair   33 ( 3 )   225 - 231   2019.3

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    DOI: 10.1177/1545968319829456

  • Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells HeyL requires HeS1 to bind diverse DNA sites Reviewed

    Yu Taro Noguchi, Miki Nakamura, Nobumasa Hino, Jumpei Nogami, Sayaka Tsuji, Takahiko Sato, Lidan Zhang, Kazutake Tsujikawa, Toru Tanaka, Kohei Izawa, Yoshiaki Okada, Takefumi Doi, Hiroki Kokubo, Akihito Harada, Akiyoshi Uezumi, Manfred Gessler, Yasuyuki Ohkawa, So Ichiro Fukada

    Development (Cambridge)   146 ( 4 )   2019.2

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    DOI: 10.1242/dev.163618

  • Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection Reviewed

    Kazu Kobayakawa, Kyleigh Alexis DePetro, Hui Zhong, Bau Pham, Masamitsu Hara, Akihito Harada, Jumpei Nogami, Yasuyuki Ohkawa, V. Reggie Edgerton

    Neurorehabilitation and Neural Repair   2019.1

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    DOI: 10.1177/1545968319829456

  • Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants Reviewed

    Mayo Araki, Massanori Kurihara, Suzuko Kinoshita, Rie Awane, Tetsuya Sato, Yasuyuki Ohkawa, Yoshihiro H. Inoue

    DMM Disease Models and Mechanisms   12 ( 6 )   2019.1

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    DOI: 10.1242/dmm.037721

  • Pathological changes of distal motor neurons after complete spinal cord injury Reviewed

    Kazuya Yokota, Kensuke Kubota, Kazu Kobayakawa, Takeyuki Saito, Masamitsu Hara, Ken Kijima, Takeshi Maeda, Hiroyuki Katoh, Yasuyuki Ohkawa, Yasuharu Nakashima, Seiji Okada

    Molecular Brain   12 ( 1 )   2019.1

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    DOI: 10.1186/s13041-018-0422-3

  • Fetal leydig cells dedifferentiate and serve as adult leydig stem cells Reviewed

    Yuichi Shima, Kanako Miyabayashi, Tetsuya Sato, Mikita Suyama, Yasuyuki Ohkawa, Masao Doi, Hitoshi Okamura, Kentaro Suzuki

    Development (Cambridge)   145 ( 23 )   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.169136

  • Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids Reviewed

    Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro Ishihara, Ju Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, Lixiang Wang, Ryuichiro Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man Ho Choi, Yasuyuki Ohkawa, Ken ichirou Morohashi

    Communications Biology   1 ( 1 )   2018.12

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    DOI: 10.1038/s42003-018-0020-z

  • Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors Reviewed

    Yasuo Takashima, Kenichi Horisawa, Miyako Udono, Yasuyuki Ohkawa, Atsushi Suzuki

    Cancer Science   109 ( 11 )   3543 - 3553   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13798

  • Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors. Reviewed International journal

    Yasuo Takashima, Kenichi Horisawa, Miyako Udono, Yasuyuki Ohkawa, Atsushi Suzuki

    Cancer science   109 ( 11 )   3543 - 3553   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13798

  • Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Reviewed International journal

    Yasuhiro Arimura, Masae Ikura, Risa Fujita, Mamiko Noda, Wataru Kobayashi, Naoki Horikoshi, Jiying Sun, Lin Shi, Masayuki Kusakabe, Masahiko Harata, Yasuyuki Ohkawa, Satoshi Tashiro, Hiroshi Kimura, Tsuyoshi Ikura, Hitoshi Kurumizaka

    Nucleic acids research   46 ( 19 )   10007 - 10018   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gky661

  • Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells Reviewed

    Nozomi Sugimoto, Kazumitsu Maehara, Kazumasa Yoshida, Yasuyuki Ohkawa, Masatoshi Fujita

    Nucleic Acids Research   46 ( 13 )   6683 - 6696   2018.7

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    DOI: 10.1093/nar/gky476

  • The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis Reviewed

    23 ( 7 )   1988 - 2000   2018.5

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    The gene encoding the chromatin remodeler CHD8 is the most frequently mutated gene in individuals with autism spectrum disorder (ASD). Heterozygous mutations in CHD8 give rise to ASD that is often accompanied by macrocephaly, gastrointestinal complaints, and slender habitus. Whereas most phenotypes of CHD8 haploinsufficiency likely result from delayed neurodevelopment, the mechanism underlying slender habitus has remained unknown. Here, we show that CHD8 interacts with CCAAT/enhancer-binding protein β (C/EBPβ) and promotes its transactivation activity during adipocyte differentiation. Adipogenesis was impaired in Chd8-deleted preadipocytes, with the upregulation of C/EBPα and peroxisome-proliferator-activated receptor γ (PPARγ), two master regulators of this process, being attenuated in mutant cells. Furthermore, mice with CHD8 ablation in white preadipocytes had a markedly reduced white adipose tissue mass. Our findings reveal a mode of C/EBPβ regulation by CHD8 during adipogenesis, with CHD8 deficiency resulting in a defect in the development of white adipose tissue. Kita et al. show that autism-related protein CHD8 is essential for adipogenesis and the development of white adipose tissue. Moreover, they demonstrate that CHD8 cooperates with C/EBPβ to regulate transactivation of the genes for C/EBPα and PPARγ during adipogenesis.

    DOI: 10.1016/j.celrep.2018.04.050

  • Direct reprogramming of spiral ganglion non-neuronal cells into neurons Toward ameliorating sensorineural hearing loss by gene therapy Reviewed

    Teppei Noda, Steven J. Meas, Jumpei Nogami, Yutaka Amemiya, Ryutaro Uchi, Yasuyuki Ohkawa, Koji Nishimura, Alain Dabdoub

    Frontiers in Cell and Developmental Biology   6 ( FEB )   2018.2

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    DOI: 10.3389/fcell.2018.00016

  • Identification of miR-305, a microRNA that promotes aging, and its target mRNAs in Drosophila Reviewed

    Makiko Ueda, Tetsuya Sato, Yasuyuki Ohkawa, Yoshihiro H. Inoue

    Genes to Cells   23 ( 2 )   80 - 93   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12555

  • Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence Reviewed

    Yoshimasa Takizawa, Hiroki Tanaka, Shinichi Machida, Masako Koyama, Kazumitsu Maehara, Yasuyuki Ohkawa, Paul A. Wade, Matthias Wolf, Hitoshi Kurumizaka

    Open Biology   8 ( 3 )   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1098/rsob.170255

  • MNase, as a probe to study the sequence-dependent site exposures in the +1 nucleosomes of yeast Reviewed

    Di Luo, Daiki Kato, Jumpei Nogami, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Hidetoshi Kono

    Nucleic acids research   46 ( 14 )   7124 - 7137   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gky502

  • Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome Reviewed

    Yasuhiro Arimura, Masae Ikura, Risa Fujita, Mamiko Noda, Wataru Kobayashi, Naoki Horikoshi, Jiying Sun, Lin Shi, Masayuki Kusakabe, Masahiko Harata, Yasuyuki Ohkawa, Satoshi Tashiro, Hiroshi Kimura, Tsuyoshi Ikura, Hitoshi Kurumizaka

    Nucleic acids research   46 ( 19 )   10007 - 10018   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gky661

  • Roles of histone H3.5 in human spermatogenesis and spermatogenic disorders Reviewed

    K. Shiraishi, A. Shindo, Akihito Harada, H. Kurumizaka, H. Kimura, Yasuyuki Ohkawa, H. Matsuyama

    Andrology   6 ( 1 )   158 - 165   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/andr.12438

  • Histone methyltransferase G9a is a key regulator of the starvation-induced behaviors in Drosophila melanogaster Reviewed

    Kouhei Shimaji, Ryo Tanaka, Toru Maeda, Mamiko Ozaki, Hideki Yoshida, Yasuyuki Ohkawa, Tetsuya Sato, Mikita Suyama, Masamitsu Yamaguchi

    Scientific Reports   7 ( 1 )   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-15344-2

  • Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi Reviewed

    Takuya Kajitani, Hiroaki Kato, Yuji Chikashige, Chihiro Tsutsumi, Yasushi Hiraoka, Hiroshi Kimura, Yasuyuki Ohkawa, Chikashi Obuse, Damien Hermand, Yota Murakami

    Proceedings of the National Academy of Sciences of the United States of America   114 ( 52 )   E11208 - E11217   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1714579115

  • Persistent detection of alternatively spliced BCR-ABL variant results in a failure to achieve deep molecular response Reviewed

    Junichiro Yuda, Toshihiro Miyamoto, Jun Odawara, Yasuyuki Ohkawa, Yuichiro Semba, Masayasu Hayashi, Koichi Miyamura, Mitsune Tanimoto, Kazuhito Yamamoto, Masafumi Taniwaki, Koichi Akashi

    Cancer Science   108 ( 11 )   2204 - 2212   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13353

  • Histone methyltransferase G9a is a key regulator of the starvation-induced behaviors in Drosophila melanogaster. Reviewed International journal

    Kouhei Shimaji, Ryo Tanaka, Toru Maeda, Mamiko Ozaki, Hideki Yoshida, Yasuyuki Ohkawa, Tetsuya Sato, Mikita Suyama, Masamitsu Yamaguchi

    Scientific reports   7 ( 1 )   14763 - 14763   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-15344-2

  • The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms Reviewed

    Yuka Adachi, Mana Umeda, Asako Kawazoe, Tetsuya Sato, Yasuyuki Ohkawa, Sakihito Kitajima, Shingo Izawa, Ikuko Sagami, Shigeru Taketani

    Archives of Biochemistry and Biophysics   631   19 - 29   2017.10

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    DOI: 10.1016/j.abb.2017.08.006

  • Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1 Reviewed

    Fumiyuki Sasaki, Tomoaki Koga, Kazuko Saeki, Toshiaki Okuno, Saiko Kazuno, Tsutomu Fujimura, Yasuyuki Ohkawa, Takehiko Yokomizo

    PLoS One   12 ( 9 )   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0185133

  • Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability Reviewed

    Kei Fukuda, Yukihiro Inoguchi, Kenji Ichiyanagi, Tomoko Ichiyanagi, Yasuhiro Go, Masashi Nagano, Yojiro Yanagawa, Noboru Takaesu, Yasuyuki Ohkawa, Hiroo Imai, Hiroyuki Sasaki

    Human Molecular Genetics   26 ( 18 )   3508 - 3519   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/hmg/ddx236

  • Interaction of reactive astrocytes with type i collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury Reviewed

    Masamitsu Hara, Kazu Kobayakawa, Yasuyuki Ohkawa, Hiromi Kumamaru, Kazuya Yokota, Takeyuki Saito, Ken Kijima, Shingo Yoshizaki, Katsumi Harimaya, Yasuharu Nakashima, Seiji Okada

    Nature Medicine   23 ( 7 )   818 - 828   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nm.4354

  • Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development Reviewed

    Kanako Miyabayashi, Yuichi Shima, Miki Inoue, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Mikita Suyama, Ken-Ichirou Morohashi

    Sexual Development   11 ( 2 )   53 - 63   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000453323

  • GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes Reviewed

    Akiyoshi Nakayama, Hirofumi Nakaoka, Ken Yamamoto, Masayuki Sakiyama, Amara Shaukat, Yu Toyoda, Yukinori Okada, Yoichiro Kamatani, Takahiro Nakamura, Tappei Takada, Katsuhisa Inoue, Tomoya Yasujima, Hiroaki Yuasa, Yuko Shirahama, Hiroshi Nakashima, Seiko Shimizu, Toshihide Higashino, Yusuke Kawamura, Hiraku Ogata, Makoto Kawaguchi, Yasuyuki Ohkawa, Inaho Danjoh, Atsumi Tokumasu, Keiko Ooyama, Toshimitsu Ito, Takaaki Kondo, Kenji Wakai, Blanka Stiburkova, Karel Pavelka, Lisa K. Stamp, Nicola Dalbeth, Yutaka Sakurai, Hiroshi Suzuki, Makoto Hosoyamada, Shin Fujimori, Takashi Yokoo, Tatsuo Hosoya, Ituro Inoue, Atsushi Takahashi, Michiaki Kubo, Hiroshi Ooyama, Toru Shimizu, Kimiyoshi Ichida, Nariyoshi Shinomiya, Tony R. Merriman, Hirotaka Matsuo

    Annals of the Rheumatic Diseases   76 ( 5 )   869 - 877   2017.5

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    DOI: 10.1136/annrheumdis-2016-209632

  • Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms Reviewed

    Tomohumi Nakamura, Kouichi Murakami, Haruto Tada, Yoshihiko Uehara, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Hisato Saitoh, Hideo Nishitani, Tetsuya Ono, Ryotaro Nishi, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa

    Genes to Cells   22 ( 4 )   392 - 405   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12481

  • Structure and function of human histone H3.Y nucleosome. Reviewed International journal

    Tomoya Kujirai, Naoki Horikoshi, Koichi Sato, Kazumitsu Maehara, Shinichi Machida, Akihisa Osakabe, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Nucleic acids research   45 ( 6 )   3612 - 3612   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkw1219

  • ROLES OF HISTONE H3.5 IN HUMAN SPERMATOGENESIS AND SPERMATOGENIC DISORDERS Reviewed

    Koji Shiraishi, Aya Shindo, Akihito Harada, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Hiroshi Kimura, Hideyasu Matsuyama

    JOURNAL OF UROLOGY   197 ( 4 )   E85 - E85   2017.4

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    DOI: 10.1016/j.juro.2017.02.277

  • Erratum Structure and function of human histone H3.Y nucleosome (Nucleic acids research (2016) 44 13 (6127-6141)) Reviewed

    Tomoya Kujirai, Naoki Horikoshi, Koichi Sato, Kazumitsu Maehara, Shinichi Machida, Akihisa Osakabe, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Nucleic acids research   45 ( 6 )   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkw1219

  • Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury Reviewed

    Kazuya Yokota, Kazu Kobayakawa, Takeyuki Saito, Masamitsu Hara, Ken Kijima, Yasuyuki Ohkawa, Akihito Harada, Ken Okazaki, Kohei Ishihara, Shigeo Yoshida, Akira Kudo, Yukihide Iwamoto, Seiji Okada

    American Journal of Pathology   187 ( 3 )   639 - 653   2017.3

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    DOI: 10.1016/j.ajpath.2016.11.010

  • Control of tissue size and development by a regulatory element in the yorkie 3'UTR Reviewed

    Takanari Umegawachi, Hideki Yoshida, Hiromu Koshida, Momoko Yamada, Yasuyuki Ohkawa, Tetsuya Sato, Mikita Suyama, Henry M. Krause, Masamitsu Yamaguchi

    American Journal of Cancer Research   7 ( 3 )   673 - 687   2017.1

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  • Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells Reviewed International journal

    Bing Li, Takashi Baba, Kanako Miyabayashi, Tetsuya Sato, Yuichi Shima, Tomomi Ichinose, Daisuke Miura, Yasuyuki Ohkawa, Mikita Suyama, Ken-Ichirou Morohashi

    Endocrine Journal   64 ( 3 )   315 - 324   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1507/endocrj.EJ16-0467

  • Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells Reviewed

    Yurin Shishido, Takash Baba, Tetsuy Sato, Yuich Shima, Kanak Miyabayashi, Mik Inoue, Haruhik Akiyama, Hirosh Kimura, Yoshiakir Kanai, Yasuhir Ishihara, Shogo Haraguchi, Akir Miyazaki, Damjan Rozman, Takesh Yamazaki, Man Ho Choi, Yasuyuki Ohkawa, Mikit Suyama, Ken-Ichirou Morohashi

    Scientific Reports   7   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep41912

  • A one-step immunostaining method to visualize rodent muscle fiber type within a single specimen Reviewed

    Shoko Sawano, Yusuke Komiya, Riho Ichitsubo, Yasuyuki Ohkawa, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi, Wataru Mizunoya

    PLoS One   11 ( 11 )   2016.11

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    DOI: 10.1371/journal.pone.0166080

  • Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma Reviewed

    Maiko Terada, Kenichi Horisawa, Shizuka Miura, Yasuo Takashima, Yasuyuki Ohkawa, Sayaka Sekiya, Kanae Matsuda-Ito, Atsushi Suzuki

    Scientific Reports   6   2016.10

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    DOI: 10.1038/srep34691

  • MRG15 is required for pre-mRNA splicing and spermatogenesis Reviewed

    Naoki Iwamori, Kaoru Tominaga, Tetsuya Sato, Kevin Riehle, Tokuko Iwamori, Yasuyuki Ohkawa, Cristian Coarfa, Etsuro Ono, Martin M. Matzuk

    Proceedings of the National Academy of Sciences of the United States of America   113 ( 37 )   E5408 - E5415   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1611995113

  • CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Reviewed International journal

    Yuta Katayama, Masaaki Nishiyama, Hirotaka Shoji, Yasuyuki Ohkawa, Atsuki Kawamura, Tetsuya Sato, Mikita Suyama, Toru Takumi, Tsuyoshi Miyakawa, Keiichi I Nakayama

    Nature   537 ( 7622 )   675 - 679   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature19357

  • LATS2 positively regulates polycomb repressive complex 2 Reviewed

    Kosuke Torigata, Okuzaki Daisuke, Satomi Mukai, Akira Hatanaka, Fumiharu Ohka, Daisuke Motooka, Shota Nakamura, Yasuyuki Ohkawa, Norikazu Yabuta, Yutaka Kondo, Hiroshi Nojima

    PLoS One   11 ( 7 )   2016.7

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    DOI: 10.1371/journal.pone.0158562

  • Structure and function of human histone H3.Y nucleosome. Reviewed International journal

    Tomoya Kujirai, Naoki Horikoshi, Koichi Sato, Kazumitsu Maehara, Shinichi Machida, Akihisa Osakabe, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Nucleic acids research   44 ( 13 )   6127 - 41   2016.7

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    DOI: 10.1093/nar/gkw202

  • TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin Reviewed

    Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Tetsuya Sato, Mikita Suyama, Yasuyuki Ohkawa, Toshiyuki Takai, Haifeng Shi, Caroline C. Philpott, Akira Nakamura

    Scientific Reports   6   2016.5

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    DOI: 10.1038/srep26566

  • The feasibility of in vivo imaging of infiltrating blood cells for predicting the functional prognosis after spinal cord injury Reviewed

    Kazuya Yokota, Takeyuki Saito, Kazu Kobayakawa, Kensuke Kubota, Masamitsu Hara, Masaharu Murata, Yasuyuki Ohkawa, Yukihide Iwamoto, Seiji Okada

    Scientific Reports   6   2016.5

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    DOI: 10.1038/srep25673

  • Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing Reviewed

    Wataru Kobayashi, Motoki Takaku, Shinichi Machida, Hiroaki Tachiwana, Kazumitsu Maehara, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Scientific Reports   6   2016.4

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    DOI: 10.1038/srep24228

  • Histone H4 lysine 20 acetylation is associated with gene repression in human cells Reviewed

    Jun Ya Kaimori, Kazumitsu Maehara, Yoko Hayashi-Takanaka, Akihito Harada, Masafumi Fukuda, Satoko Yamamoto, Naotsugu Ichimaru, Takashi Umehara, Shigeyuki Yokoyama, Ryo Matsuda, Tsuyoshi Ikura, Koji Nagao, Chikashi Obuse, Naohito Nozaki, Shiro Takahara, Toshifumi Takao, Yasuyuki Ohkawa, Hiroshi Kimura, Yoshitaka Isaka

    Scientific Reports   6   2016.4

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    DOI: 10.1038/srep24318

  • Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2 Reviewed

    Masayasu Hayashi, Kazumitsu Maehara, Akihito Harada, Yuichiro Semba, Kensuke Kudo, Hidehisa Takahashi, Shinya Oki, Chikara Meno, Kenji Ichiyanagi, Koichi Akashi, Yasuyuki Ohkawa

    Journal of Cellular Biochemistry   117 ( 3 )   780 - 792   2016.3

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    DOI: 10.1002/jcb.25368

  • Isolation and characterization of Fetal Leydig progenitor cells of male mice Reviewed

    Miki Inoue, Yuichi Shima, Kanako Miyabayashi, Kaori Tokunaga, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Haruhiko Akiyama, Mikita Suyama, Ken-Ichirou Morohashi

    Endocrinology   157 ( 3 )   1222 - 1233   2016.3

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    DOI: 10.1210/en.2015-1773

  • Identification of low-abundance proteins in serum via the isolation of HSP72 complexes Reviewed

    Masako Tanaka, Masayuki Shiota, Takafumi Nakao, Ryo Uemura, Satoshi Nishi, Yasuyuki Ohkawa, Masaki Matsumoto, Maki Yamaguchi, Mayuko Osada-Oka, Azusa Inagaki, Katsuyuki Takahashi, Keiichi Nakayama, Min Gi, Yasukatsu Izumi, Katsuyuki Miura, Hiroshi Iwao

    Journal of Proteomics   136   214 - 221   2016.3

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    DOI: 10.1016/j.jprot.2016.01.008

  • CHD8 haploinsufficiency results in autistic-like phenotypes in mice Reviewed

    Yuta Katayama, Masaaki Nishiyama, Hirotaka Shoji, Yasuyuki Ohkawa, Atsuki Kawamura, Tetsuya Sato, Mikita Suyama, Toru Takumi, Tsuyoshi Miyakawa, Keiichi Nakayama

    Nature   537 ( 7622 )   675 - 679   2016.1

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    DOI: 10.1038/nature19357

  • Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis Reviewed

    Takashi Urahama, Akihito Harada, Kazumitsu Maehara, Naoki Horikoshi, Koichi Sato, Yuko Sato, Koji Shiraishi, Norihiro Sugino, Akihisa Osakabe, Hiroaki Tachiwana, Wataru Kagawa, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Epigenetics and Chromatin   9 ( 1 )   2016.1

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    DOI: 10.1186/s13072-016-0051-y

  • Exploration of nucleosome positioning patterns in transcription factor function Reviewed

    Kazumitsu Maehara, Yasuyuki Ohkawa

    Scientific Reports   6   2016.1

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    DOI: 10.1038/srep19620

  • Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes Reviewed

    Masahiro Oka, Sonoko Mura, Kohji Yamada, Percival Sangel, Saki Hirata, Kazumitsu Maehara, Koichi Kawakami, Taro Tachibana, Yasuyuki Ohkawa, Hiroshi Kimura, Yoshihiro Yoneda

    eLife   5 ( JANUARY2016 )   2016.1

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    DOI: 10.7554/eLife.09540

  • Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies Reviewed

    Yoko Hayashi-Takanaka, Kazumitsu Maehara, Akihito Harada, Takashi Umehara, Shigeyuki Yokoyama, Chikashi Obuse, Yasuyuki Ohkawa, Naohito Nozaki, Hiroshi Kimura

    Chromosome Research   23 ( 4 )   753 - 766   2015.12

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    DOI: 10.1007/s10577-015-9486-4

  • Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis Reviewed

    Kouhei Shimaji, Takahiro Konishi, Shintaro Tanaka, Hideki Yoshida, Yasuko Kato, Yasuyuki Ohkawa, Tetsuya Sato, Mikita Suyama, Hiroshi Kimura, Masamitsu Yamaguchi

    Genes to Cells   20 ( 11 )   902 - 914   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12281

  • Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons Reviewed

    Yuki Hatanaka, Kimiko Inoue, Mami Oikawa, Satoshi Kamimura, Narumi Ogonuki, Eiichi N. Kodama, Yasuyuki Ohkawa, Yuichi Tsukada, Atsuo Ogura

    Proceedings of the National Academy of Sciences of the United States of America   112 ( 47 )   14641 - 14646   2015.11

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    DOI: 10.1073/pnas.1512775112

  • Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA Reviewed

    Akihisa Osakabe, Fumiya Adachi, Yasuhiro Arimura, Kazumitsu Maehara, Yasuyuki Ohkawa, Hitoshi Kurumizaka

    Open Biology   5 ( 10 )   2015.10

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    DOI: 10.1098/rsob.150128

  • Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury. Reviewed International journal

    Kazuya Yokota, Kazu Kobayakawa, Kensuke Kubota, Atsushi Miyawaki, Hideyuki Okano, Yasuyuki Ohkawa, Yukihide Iwamoto, Seiji Okada

    Stem cell reports   5 ( 2 )   264 - 77   2015.8

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    DOI: 10.1016/j.stemcr.2015.06.004

  • Agplus A rapid and flexible tool for aggregation plots Reviewed

    Kazumitsu Maehara, Yasuyuki Ohkawa

    Bioinformatics   31 ( 18 )   3046 - 3047   2015.7

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    DOI: 10.1093/bioinformatics/btv322

  • Sex determination. foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka. Reviewed International journal

    Toshiya Nishimura, Tetsuya Sato, Yasuhiro Yamamoto, Ikuko Watakabe, Yasuyuki Ohkawa, Mikita Suyama, Satoru Kobayashi, Minoru Tanaka

    Science (New York, N.Y.)   349 ( 6245 )   328 - 31   2015.7

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    DOI: 10.1126/science.aaa2657

  • Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. Reviewed International journal

    Nozomi Sugimoto, Kazumitsu Maehara, Kazumasa Yoshida, Shuhei Yasukouchi, Satoko Osano, Shinya Watanabe, Masahiro Aizawa, Takashi Yugawa, Tohru Kiyono, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Masatoshi Fujita

    Nucleic acids research   43 ( 12 )   5898 - 911   2015.7

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    DOI: 10.1093/nar/gkv509

  • Foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka Reviewed

    Toshiya Nishimura, Tetsuya Sato, Yasuhiro Yamamoto, Ikuko Watakabe, Yasuyuki Ohkawa, Mikita Suyama, Satoru Kobayashi, Minoru Tanaka

    Science   349 ( 6245 )   328 - 331   2015.7

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    DOI: 10.1126/science.aaa2657

  • Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme Reviewed

    Nature Communications   6   2015.6

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    DOI: 10.1038/ncomms8441

  • PSMC5, a 19S proteasomal ATPase, regulates cocaine action in the nucleus accumbens Reviewed

    Yoko H. Ohnishi, Yoshinori N. Ohnishi, Takanori Nakamura, Mizuki Ohno, Pamela J. Kennedy, Ohkawa Yasuyuki, Akinori Nishi, Rachael Neve, Teruhisa Tsuzuki, Eric J. Nestler

    PloS one   10 ( 5 )   2015.5

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    DOI: 10.1371/journal.pone.0131263

  • A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation Reviewed

    Saori Tomita, Mohamed Osama Ali Abdalla, Saori Fujiwara, Haruka Matsumori, Kazumitsu Maehara, Yasuyuki Ohkawa, Hirotaka Iwase, Noriko Saitoh, Mitsuyoshi Nakao

    Nature Communications   6   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms7966

  • SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies Reviewed

    Tetsuya Kawaguchi, Akie Tanigawa, Takao Naganuma, Yasuyuki Ohkawa, Sylvie Souquere, Gerard Pierron, Tetsuro Hirose, Joan A. Steitz

    Proceedings of the National Academy of Sciences of the United States of America   112 ( 14 )   4304 - 4309   2015.4

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    DOI: 10.1073/pnas.1423819112

  • A genome-wide analysis identifies a Notch-RBP-Jk-IL-7Ra axis that controls IL-17-Producing γδ T cell homeostasis in mice Reviewed

    194 ( 1 )   243 - 251   2015.1

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    Notch signaling is an important regulator for the development and function of both ab and γδ T cells, whereas roles of Notch signaling in T cell maintenance remain unclear. We reported previously that the Notch-Hes1 pathway was involved in the intrathymic development of naturally occurring IL-17-producing (IL-17+) γδ T cells. To gain insight into additional roles for the Notch axis in the homeostasis of γδ T cells, we performed a genome-wide analysis of Notch target genes and identified the novel promoter site of IL-7Ra driven by the Notch-RBP-Jk pathway. Constitutive Notch signaling had the potential to induce IL-7Ra expression on γδ T cells in vivo, as well as in vitro, whereas conditional deletion of RBP-Jk abrogated IL-7Ra expression, but not Hes1 expression, by γδ T cells and selectively reduced the pool size of IL-7Rahigh IL-17+ γδ T cells in the periphery. In the absence of IL-7Ra-mediated signaling, IL-17+ γδ T cells were barely maintained in adult mice. Addition of exogenous IL-7 in vitro selectively expanded IL-17+ γδ T cells. Thus, our results revealed a novel role for the Notch-RBP-Jk-IL-7Ra axis that is independent of Hes1 for homeostasis of IL-17+ γδ T cells.

    DOI: 10.4049/jimmunol.1401619

  • MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex Reviewed

    Hidehisa Takahashi, Ichigaku Takigawa, Masashi Watanabe, Delnur Anwar, Mio Shibata, Chieri Tomomori-Sato, Shigeo Sato, Amol Ranjan, Chris W. Seidel, Tadasuke Tsukiyama, Wataru Mizushima, Masayasu Hayashi, Yasuyuki Ohkawa, Joan W. Conaway, Ronald C. Conaway, Shigetsugu Hatakeyama

    Nature Communications   6   2015.1

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    DOI: 10.1038/ncomms6941

  • Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury Reviewed

    Kazuya Yokota, Kazu Kobayakawa, Kensuke Kubota, Atsushi Miyawaki, Hideyuki Okano, Yasuyuki Ohkawa, Yukihide Iwamoto, Seiji Okada

    Stem Cell Reports   5 ( 2 )   264 - 277   2015.1

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    DOI: 10.1016/j.stemcr.2015.06.004

  • Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture Reviewed

    Nozomi Sugimoto, Kazumitsu Maehara, Kazumasa Yoshida, Shuhei Yasukouchi, Satoko Osano, Shinya Watanabe, Masahiro Aizawa, Takashi Yugawa, Tohru Kiyono, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Masatoshi Fujita

    Nucleic Acids Research   43 ( 12 )   5898 - 5911   2015.1

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    DOI: 10.1093/nar/gkv509

  • Regulation of RNA polymerase II activation by histone acetylation in single living cells Reviewed

    Timothy J. Stasevich, Yoko Hayashi-Takanaka, Yuko Sato, Kazumitsu Maehara, Yasuyuki Ohkawa, Kumiko Sakata-Sogawa, Makio Tokunaga, Takahiro Nagase, Naohito Nozaki, James G. McNally, Hiroshi Kimura

    Nature   516 ( 7530 )   272 - 275   2014.12

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    DOI: 10.1038/nature13714

  • Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. Reviewed International journal

    Masanori Matsumoto, Akemi Baba, Takafumi Yokota, Hiroyoshi Nishikawa, Yasuyuki Ohkawa, Hisako Kayama, Axel Kallies, Stephen L Nutt, Shimon Sakaguchi, Kiyoshi Takeda, Tomohiro Kurosaki, Yoshihiro Baba

    Immunity   41 ( 6 )   1040 - 51   2014.12

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    DOI: 10.1016/j.immuni.2014.10.016

  • Genome-wide analysis of histone modifications in human endometrial stromal cells Reviewed

    Isao Tamura, Yasuyuki Ohkawa, Tetsuya Sato, Mikita Suyama, Kosuke Jozaki, Maki Okada, Lifa Lee, Ryo Maekawa, Hiromi Asada, Shun Sato, Yoshiaki Yamagata, Hiroshi Tamura, Norihiro Sugino

    Molecular Endocrinology   28 ( 10 )   1656 - 1669   2014.10

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    DOI: 10.1210/me.2014-1117

  • Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans. Reviewed International journal

    Kazu Kobayakawa, Hiromi Kumamaru, Hirokazu Saiwai, Kensuke Kubota, Yasuyuki Ohkawa, Junji Kishimoto, Kazuya Yokota, Ryosuke Ideta, Keiichiro Shiba, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Yukihide Iwamoto, Seiji Okada

    Science translational medicine   6 ( 256 )   256ra137   2014.10

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    DOI: 10.1126/scitranslmed.3009430

  • Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2 Reviewed

    Masako Tanaka, Maki Yamaguchi, Masayuki Shiota, Yukiko Kawamoto, Katsuyuki Takahashi, Azusa Inagaki, Mayuko Osada-Oka, Akihito Harada, Hideki Wanibuchi, Yasukatsu Izumi, Katsuyuki Miura, Hiroshi Iwao, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   33 ( 4 )   261 - 269   2014.8

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    DOI: 10.1089/mab.2013.0085

  • Erratum Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO (Stem Cell Reports (2014) 2 (910-924)) Reviewed

    Jun Ueda, Kazumitsu Maehara, Daisuke Mashiko, Takako Ichinose, Tatsuma Yao, Mayuko Hori, Yuko Sato, Hiroshi Kimura, Yasuyuki Ohkawa, Kazuo Yamagata

    Stem Cell Reports   3 ( 1 )   2014.7

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    DOI: 10.1016/j.stemcr.2014.06.006

  • Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, methylRO Reviewed

    Jun Ueda, Kazumitsu Maehara, Daisuke Mashiko, Takako Ichinose, Tatsuma Yao, Mayuko Hori, Yuko Sato, Hiroshi Kimura, Yasuyuki Ohkawa, Kazuo Yamagata

    Stem Cell Reports   2 ( 6 )   910 - 924   2014.6

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    DOI: 10.1016/j.stemcr.2014.05.008

  • Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex Reviewed

    Atsushi Yokoyama, Katsuhide Igarashi, Tetsuya Sato, Kiyoshi Takagi, Maky I. Otsuka, Yurina Shishido, Takashi Baba, Ryo Ito, Jun Kanno, Yasuyuki Ohkawa, Ken-Ichirou Morohashi, Akira Sugawara

    Journal of Biological Chemistry   289 ( 26 )   18152 - 18162   2014.6

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    DOI: 10.1074/jbc.M114.566448

  • Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions Reviewed

    Masako Tanaka, Saya Mun, Akihito Harada, Yasuyuki Ohkawa, Azusa Inagaki, Soichi Sano, Katsuyuki Takahashi, Yasukatsu Izumi, Mayuko Osada-Oka, Hideki Wanibuchi, Masayo Yamagata, Tokihito Yukimura, Katsuyuki Miura, Masayuki Shiota, Hiroshi Iwao

    PLoS One   9 ( 5 )   2014.5

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    DOI: 10.1371/journal.pone.0096785

  • Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1 Reviewed

    Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon Chu Chung, Ken-Ichirou Morohashi

    Nature Communications   5   2014.4

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    DOI: 10.1038/ncomms4634

  • Generation of a monoclonal antibody for INI1/hSNF5/BAF47 Reviewed

    Akihito Harada, Masayasu Hayashi, Yuuki Kuniyoshi, Yuichiro Semba, Satoko Sugahara, Taro Tachibana, Yasuyuki Ohkawa, Masatoshi Fujita

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   33 ( 1 )   49 - 51   2014.2

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    DOI: 10.1089/mab.2013.0065

  • Production of a monoclonal antibody for C/EBPβ The subnuclear localization of C/EBPβ in mouse L929 cells Reviewed

    33 ( 1 )   34 - 37   2014.2

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    The CCAAT/enhancer-binding protein (C/EBP)β belongs to the C/EBP family of proteins that possesses a basic leucine zipper DNA-binding domain. These proteins bind DNA by dimerization and play a role in the transcriptional regulation of various cells. There are six different types of C/EBPs, and some form isoforms through the use of alternative translation initiation sites. The functional analysis of the C/EBP family is therefore difficult to achieve. Here we report on the production of specific monoclonal antibodies against mouse C/EBPβ using a rat medial iliac lymph node method. Immunoblotting using C/EBPβ monoclonal antibodies identified two types of isoforms, while immunostaining revealed a subnuclear localization for C/EBPβ. Use of this antibody should contribute to the further elucidation of the transcriptional regulatory function of C/EBPβ.

    DOI: 10.1089/mab.2013.0069

  • Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans Reviewed

    Kazu Kobayakawa, Hiromi Kumamaru, Hirokazu Saiwai, Kensuke Kubota, Yasuyuki Ohkawa, Junji Kishimoto, Kazuya Yokota, Ryosuke Ideta, Keiichiro Shiba, Hidetoshi Saitoh, Kazuhide Inoue, Yukihide Iwamoto, Seiji Okada

    Science Translational Medicine   6 ( 256 )   2014.1

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    DOI: 10.1126/scitranslmed.3009430

  • The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase a dependent manner Reviewed

    9 ( 1 )   2014.1

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    Differentiation signaling results in reprogramming of cellular gene expression that leads to morphological changes and functional specialization of a precursor cell. This global change in gene expression involves temporal regulation of differentiation-specific genes that are located throughout the genome, raising the idea that genome structure may also be re-organized during cell differentiation to facilitate regulated gene expression. Using in vitro adipocyte differentiation as a model, we explored whether gene organization within the nucleus is altered upon exposure of precursor cells to signaling molecules that induce adipogenesis. The peroxisome proliferator-activated receptor gamma (PPARγ) nuclear hormone receptor is a master determinant of adipogenesis and is required for adipose differentiation. We utilized the chromosome conformation capture (3C) assay to determine whether the position of the PPARc locus relative to other adipogenic genes is changed during differentiation. We report that the PPARγ2 promoter is transiently positioned in proximity to the promoters of genes encoding adipokines and lipid droplet associated proteins at 6 hours post-differentiation, a time that precedes expression of any of these genes. In contrast, the PPARγ2 promoter was not in proximity to the EF1α promoter, which drives expression of a constitutively active, housekeeping gene that encodes a translation elongation factor, nor was the PPARγ2 promoter in proximity to the promoter driving the expression of the C/EBPα regulatory protein. The formation of the long-range, intergenic interactions involving the PPARγ2 promoter required the regulatory factor C/EBPβ, elevated cyclic AMP (cAMP) levels, and protein kinase A (PKA) signaling. We conclude that genome organization is dynamically remodeled in response to adipogenic signaling, and we speculate that these transient inter-genic interactions may be formed for the purposes of selecting some of the transcriptionally silent tissue-specific loci for subsequent transcriptional activation.

    DOI: 10.1371/journal.pone.0086140

  • SraTailor Graphical user interface software for processing and visualizing ChIP-seq data Reviewed

    Shinya Oki, Kazumitsu Maehara, Yasuyuki Ohkawa, Chikara Meno

    Genes to Cells   19 ( 12 )   919 - 926   2014.1

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    DOI: 10.1111/gtc.12190

  • Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation Reviewed

    Masanori Matsumoto, Akemi Baba, Takafumi Yokota, Hiroyoshi Nishikawa, Yasuyuki Ohkawa, Hisako Kayama, Axel Kallies, Stephen L. Nutt, Shimon Sakaguchi, Kiyoshi Takeda, Tomohiro Kurosaki, Yoshihiro Baba

    Immunity   41 ( 6 )   1040 - 1051   2014.1

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    DOI: 10.1016/j.immuni.2014.10.016

  • Visualization Of Normal and Malignant Epigenetic Regulation In Hematopoiesis Utilizing Newly-Developed Histone Variant H3.3 Chipseq Analysis Reviewed

    Odawara Jun, Miyawaki Kohta, Yuda Junichiro, Hayashi Masayasu, Maehara Kazumitsu, Shima Takahiro, Kikushige Yoshikane, Ohkawa Yasuyuki, Akashi Koichi

    BLOOD   122 ( 21 )   2013.11

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    Visualization Of Normal and Malignant Epigenetic Regulation In Hematopoiesis Utilizing Newly-Developed Histone Variant H3.3 Chipseq Analysis

  • Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I Reviewed

    Jun Katahira, Daisuke Okuzaki, Hitomi Inoue, Yoshihiro Yoneda, Kazumitsu Maehara, Yasuyuki Ohkawa

    Nucleic Acids Research   41 ( 14 )   7060 - 7072   2013.8

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    DOI: 10.1093/nar/gkt414

  • Wnt signaling regulates left-right axis formation in the node of mouse embryos Reviewed

    Keiko Kitajima, Shinya Oki, Yasuyuki Ohkawa, Tomoyuki Sumi, Chikara Meno

    Developmental Biology   380 ( 2 )   222 - 232   2013.8

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    DOI: 10.1016/j.ydbio.2013.05.011

  • Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord Reviewed

    Hiromi Kumamaru, Hirokazu Saiwai, Kensuke Kubota, Kazu Kobayakawa, Kazuya Yokota, Yasuyuki Ohkawa, Keiichiro Shiba, Yukihide Iwamoto, Seiji Okada

    Stem Cells   31 ( 8 )   1535 - 1547   2013.8

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    DOI: 10.1002/stem.1404

  • β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation Reviewed

    32 ( 29 )   3477 - 3482   2013.7

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    The Wnt/β-catenin signaling is essential for various organogenesis and is often implicated during tumorigenesis. Dysregulated β-catenin signaling is associated with the formation of endometrial adenocarcinomas (EACs), which is considered as the common form of endometrial cancer in women. In the current study, we investigate the downstream target of Wnt/β-catenin signaling in the uterine epithelia and the mechanism leading to the formation of endometrial hyperplasia. We report that conditional ablation and activation of β-catenin in the uterine epithelia lead to aberrant epithelial structures and endometrial hyperplasia formation, respectively. We demonstrate that β-catenin regulates Foxa2 with its candidate upstream region for the uterine epithelia. Furthermore, knockdown of Foxa2 leads to defects in cell cycle regulation, suggesting a possible function of Foxa2 in the control of cell proliferation. We also observe that β-catenin and Foxa2 expression levels are augmented in the human specimens of complex atypical endometrial hyperplasia, which is considered to have a greater risk of progression to EACs. Thus, our study indicates that β-catenin regulates Foxa2 expression, and this interaction is possibly essential to control cell cycle progression during endometrial hyperplasia formation. Altogether, the augmented expression levels of β-catenin and Foxa2 are essential features during the formation of endometrial hyperplasia.

    DOI: 10.1038/onc.2012.376

  • A panel of specific monoclonal antibodies directed against various phosphorylated histones H3 Reviewed

    Tomohiko Yoshimi, Yasuyuki Ohkawa, Masayuki Azuma, Taro Tachibana

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   32 ( 2 )   119 - 124   2013.4

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    DOI: 10.1089/mab.2012.0105

  • Ly6C+Ly6G-Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury Reviewed

    Hirokazu Saiwai, Hiromi Kumamaru, Yasuyuki Ohkawa, Kensuke Kubota, Kazu Kobayakawa, Hisakata Yamada, Takehiko Yokomizo, Yukihide Iwamoto, Seiji Okada

    Journal of Neurochemistry   125 ( 1 )   74 - 88   2013.4

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    DOI: 10.1111/jnc.12135

  • Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells Reviewed

    Hiromi Kumamaru, Yasuyuki Ohkawa, Hirokazu Saiwai, Hisakata Yamada, Kensuke Kubota, Kazu Kobayakawa, Koichi Akashi, Hideyuki Okano, Yukihide Iwamoto, Seiji Okada

    Nature Communications   3   2012.11

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    DOI: 10.1038/ncomms2132

  • Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal cord injury Reviewed

    Kensuke Kubota, Hirokazu Saiwai, Hiromi Kumamaru, Takeshi Maeda, Yasuyuki Ohkawa, Yasuaki Aratani, Tetsuo Nagano, Yukihide Iwamoto, Seiji Okada

    Spine   37 ( 16 )   1363 - 1369   2012.7

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    DOI: 10.1097/BRS.0b013e31824b9e77

  • Surf4 modulates STIM1-dependent calcium entry Reviewed

    Yoko Fujii, Masayuki Shiota, Yasuyuki Ohkawa, Akemi Baba, Hideki Wanibuchi, Tatsuo Kinashi, Tomohiro Kurosaki, Yoshihiro Baba

    Biochemical and Biophysical Research Communications   422 ( 4 )   615 - 620   2012.6

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    DOI: 10.1016/j.bbrc.2012.05.037

  • Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury Reviewed

    Hiromi Kumamaru, Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Yukihide Iwamoto, Seiji Okada

    Journal of Cellular Physiology   227 ( 4 )   1335 - 1346   2012.4

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    DOI: 10.1002/jcp.22845

  • An improved restriction enzyme accessibility assay for analyzing changes in chromatin structure in samples of limited cell number

    Yasuyuki Ohkawa, Chandrashekara Mallappa, Caroline S Dacwag Vallaster, Anthony N. Imbalzano

    Myogenesis Methods and Protocols   798   531 - 542   2012.1

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    DOI: 10.1007/978-1-61779-343-1_32

  • Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays

    Yasuyuki Ohkawa, Chandrashekara Mallappa, Caroline S Dacwag Vallaster, Anthony N. Imbalzano

    Myogenesis Methods and Protocols   798   517 - 530   2012.1

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    DOI: 10.1007/978-1-61779-343-1_31

  • The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach Reviewed

    Jun Odawara, Akihito Harada, Tomohiko Yoshimi, Kazumitsu Maehara, Taro Tachibana, Seiji Okada, Koichi Akashi, Yasuyuki Ohkawa

    BMC Genomics   12   2011.10

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    DOI: 10.1186/1471-2164-12-516

  • Generation of a rat monoclonal antibody specific for Hsp72 Reviewed

    Masako Tanaka, Masayuki Shiota, Seiji Okada, Akihito Harada, Jun Odawara, Saya Mun, Hiroshi Iwao, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   30 ( 4 )   397 - 400   2011.8

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    DOI: 10.1089/hyb.2011.0015

  • Flow cytometric sorting of neuronal and glial nuclei from central nervous system tissue Reviewed

    Seiji Okada, Hirokazu Saiwai, Hiromi Kumamaru, Kensuke Kubota, Akihito Harada, Masahiro Yamaguchi, Yukihide Iwamoto, Yasuyuki Ohkawa

    Journal of Cellular Physiology   226 ( 2 )   552 - 558   2011.2

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    DOI: 10.1002/jcp.22365

  • Chromatin accessibility and transcription factor binding at the PPARγ2 promoter during adipogenesis is protein kinase A-dependent Reviewed

    226 ( 1 )   86 - 93   2011.1

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    The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that specifies formation of the adipocyte lineage. PPARγ also serves as a primary target for the treatment of type 2 diabetes, illustrating both its medical relevance as well as the need to understand fundamental aspects of PPARγ expression and function. Here, we characterize molecular changes that occur at the PPARγ2 promoter within the first several hours of adipocyte differentiation in culture. Our results demonstrate that changes in chromatin accessibility at the PPARγ2 promoter and occupancy of the promoter by the c-Fos transcription factor occur within an hour of the onset of differentiation, followed closely by the binding of the CCAAT/enhancer binding protein beta (C/EBPβ) transcription factor. All three events show a remarkable dependency on protein kinase A (PKA) activity. These results reflect novel requirements for the PKA signaling pathway and reinforce the importance of PKA function during the onset of adipocyte differentiation.

    DOI: 10.1002/jcp.22308

  • Ossification of the posterior longitudinal ligament of the lumbar spine A case series Reviewed

    Seiji Okada, Takeshi Maeda, Hirokazu Saiwai, Yasuyuki Ohkawa, Keiichiro Shiba, Yukihide Iwamoto

    Neurosurgery   67 ( 5 )   1311 - 1318   2010.11

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    DOI: 10.1227/NEU.0b013e3181ef2806

  • Generation of a rat monoclonal antibody specific for heat shock cognate protein 70 Reviewed

    Masayuki Shiota, Hirokazu Saiwai, Saya Mun, Akihito Harada, Seiji Okada, Jun Odawara, Masako Tanaka, Hiroshi Iwao, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 5 )   453 - 456   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2010.0024

  • Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function Reviewed

    Molecular and Cellular Biology   30 ( 13 )   3176 - 3186   2010.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/MCB.00214-10

  • Monoclonal antibodies 6D2 and 8H3 against mouse Chd2 Reviewed

    Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   270   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2010.0025.MAb

  • Rat monoclonal antibody specific for MyoD Reviewed

    Akihito Harada, Yasuyuki Ohkawa, Shinpei Ao, Jun Odawara, Seiji Okada, Masayuki Azuma, Yuko Nishiyama, Mako Nakamura, Taro Tachibana

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   255 - 258   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0117

  • Rat monoclonal antibody specific for the chromatin remodeling factor, CHD1 Reviewed

    Saori Yoshimura, Akihito Harada, Jun Odawara, Masayuki Azuma, Seiji Okada, Mako Nakamura, Yasuyuki Ohkawa, Taro Tachibana

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   237 - 240   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0106

  • Monoclonal antibody specific for Dhx9/NDHII/RHA Reviewed

    Manato Kotani, Akihito Harada, Jun Odawara, Masayuki Azuma, Seiji Okada, Yuko Nishiyama, Mako Nakamura, Taro Tachibana, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   259 - 261   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0107

  • Monoclonal antibody 8E3 against mouse Dhx9/NDHII/RHA Reviewed

    Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   269   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2010.0026.MAb

  • The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. Reviewed International journal

    Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Hiromi Kumamaru, Akihito Harada, Hideyuki Okano, Takehiko Yokomizo, Yukihide Iwamoto, Seiji Okada

    The American journal of pathology   176 ( 5 )   2352 - 66   2010.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2353/ajpath.2010.090839

  • Generation of a rat monoclonal antibody specific for Chd2 Reviewed

    Akihito Harada, Saori Yoshimura, Jun Odawara, Masayuki Azuma, Seiji Okada, Mako Nakamura, Taro Tachibana, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 2 )   173 - 177   2010.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0090

  • A rat monoclonal antibody against the chromatin remodeling factor CHD5 Reviewed

    Saori Yoshimura, Tomohiko Yoshimi, Yasuyuki Ohkawa, Masayuki Azuma, Taro Tachibana

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 1 )   63 - 66   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0069

  • Production of a rat monoclonal antibody specific for Myf5. Reviewed International journal

    Akihito Harada, Seiji Okada, Jun Odawara, Hiromi Kumamaru, Hirokazu Saiwai, Mayumi Aoki, Mako Nakamura, Yuko Nishiyama, Yasuyuki Ohkawa

    Hybridoma (2005)   29 ( 1 )   59 - 62   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0066

  • Production of a rat monoclonal antibody specific for Myf5 Reviewed

    Akihito Harada, Seiji Okada, Jun Odawara, Hiromi Kumamaru, Hirokazu Saiwai, Mayumi Aoki, Mako Nakamura, Yuko Nishiyama, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 1 )   59 - 62   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0066

  • Monoclonal antibody 1H7A10 against mouse Brm Reviewed

    Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 1 )   82   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0077.MAb

  • Monoclonal antibody 1E2G4 against mouse Myf5 Reviewed

    Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 1 )   74   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0089.MAb

  • Monoclonal antibodies 2F12H4 and 3C3F1 against mouse Pax7 Reviewed

    Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 1 )   83   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0076.MAb

  • The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury Reviewed

    Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Hiromi Kumamaru, Akihito Harada, Hideyuki Okano, Takehiko Yokomizo, Yukihide Iwamoto, Seiji Okada

    American Journal of Pathology   176 ( 5 )   2352 - 2366   2010.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2353/ajpath.2010.090839

  • Generation of a rat monoclonal antibody specific for Pax7 Reviewed

    Akihito Harada, Seiji Okada, Hirokazu Saiwai, Mayumi Aoki, Mako Nakamura, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   28 ( 6 )   451 - 453   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0039

  • Production of a rat monoclonal antibody against Brg1 Reviewed

    Yasuyuki Ohkawa, Akihito Harada, Mako Nakamura, Saori Yoshimura, Taro Tachibana

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   28 ( 6 )   463 - 466   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0041

  • Generation of a rat monoclonal antibody specific for Brm Reviewed

    Seiji Okada, Akihito Harada, Hirokazu Saiwai, Mako Nakamura, Yasuyuki Ohkawa

    Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   28 ( 6 )   455 - 458   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0044

  • Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury? Reviewed

    Seiji Okada, Takeshi Maeda, Yasuyuki Ohkawa, Katsumi Harimaya, Hirokazu Saiwai, Hiromi Kumamaru, Yoshihiro Matsumoto, Toshio Doi, Takayoshi Ueta, Keiichiro Shiba, Yukihide Iwamoto

    Spine   34 ( 11 )   1148 - 1152   2009.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0b013e31819e3215

  • Erratum Mutation of the SNF2 family member Chd2 affects mouse development and survival (Journal of Cellular Physiology (2006) 209, (162-171)) Reviewed

    Concetta G.A. Marfella, Yasuyuki Ohkawa, Andrew H. Coles, David S. Garlick, Stephen N. Jones, Anthony N. Imbalzano

    Journal of cellular physiology   212 ( 2 )   2007.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.21088

  • Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis Reviewed

    Yasuyuki Ohkawa, Saori Yoshimura, Chiduru Higashi, Concetta G A Marfella, Caroline S. Dacwag, Taro Tachibana, Anthony N. Imbalzano

    Journal of Biological Chemistry   282 ( 9 )   6564 - 6570   2007.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M608898200

  • The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling Reviewed

    Molecular and Cellular Biology   27 ( 1 )   384 - 394   2007.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/MCB.01528-06

  • Mutation of the SNF2 family member Chd2 affects mouse development and survival Reviewed

    Concetta G A Marfella, Yasuyuki Ohkawa, Andrew H. Coles, David S. Garlick, Stephen N. Jones, Anthony N. Imbalzano

    Journal of Cellular Physiology   209 ( 1 )   162 - 171   2006.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.20718

  • Mutation of the SNF2 family member Chd2 affects mouse development and survival. Reviewed International journal

    Concetta G A Marfella, Yasuyuki Ohkawa, Andrew H Coles, David S Garlick, Stephen N Jones, Anthony N Imbalzano

    Journal of cellular physiology   209 ( 1 )   162 - 71   2006.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.20718

  • The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes Reviewed

    Ivana L. De La Serna, Yasuyuki Ohkawa, Chiduru Higashi, Chaitali Dutta, Jules Osias, Naveen Kommajosyula, Taro Tachibana, Anthony N. Imbalzano

    Journal of Biological Chemistry   281 ( 29 )   20233 - 20241   2006.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M512052200

  • Chromatin remodelling in mammalian differentiation Lessons from ATP-dependent remodellers Reviewed

    Ivana L. De La Serna, Yasuyuki Ohkawa, Anthony N. Imbalzano

    Nature Reviews Genetics   7 ( 6 )   461 - 473   2006.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nrg1882

  • Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1 Reviewed

    Yasuyuki Ohkawa, Concetta G A Marfella, Anthony N. Imbalzano

    EMBO Journal   25 ( 3 )   490 - 501   2006.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.emboj.7600943

  • MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex Reviewed

    Ivana L. De La Serna, Yasuyuki Ohkawa, Charlotte A. Berkes, Donald A. Bergstrom, Caroline S. Dacwag, Stephen J. Tapscott, Anthony N. Imbalzano

    Molecular and Cellular Biology   25 ( 10 )   3997 - 4009   2005.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/MCB.25.10.3997-4009.2005

  • SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation Reviewed

    Daniel W. Young, Jitesh Pratap, Amjad Javed, Brian Weiner, Yasuyuki Ohkawa, Andre Van Wijnen, Martin Montecino, Gary S. Stein, Janet L. Stein, Anthony N. Imbalzano, Jane B. Lian

    Journal of Cellular Biochemistry   94 ( 4 )   720 - 730   2005.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcb.20332

  • SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. Reviewed International journal

    Daniel W Young, Jitesh Pratap, Amjad Javed, Brian Weiner, Yasuyuki Ohkawa, Andre van Wijnen, Martin Montecino, Gary S Stein, Janet L Stein, Anthony N Imbalzano, Jane B Lian

    Journal of cellular biochemistry   94 ( 4 )   720 - 30   2005.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcb.20332

  • Epiregulin as a Major Autocrine/Paracrine Factor Released from ERK- and p38MAPK-Activated Vascular Smooth Muscle Cells Reviewed

    Masanori Takahashi, Ken'ichiro Hayashi, Kenji Yoshida, Yasuyuki Ohkawa, Toshi Komurasaki, Akira Kitabatake, Akira Ogawa, Wataru Nishida, Masahiko Yano, Morito Monden, Kenji Sobue

    Circulation   108 ( 20 )   2524 - 2529   2003.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.CIR.0000096482.02567.8C

  • Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells. Reviewed International journal

    Masanori Takahashi, Ken'ichiro Hayashi, Kenji Yoshida, Yasuyuki Ohkawa, Toshi Komurasaki, Akira Kitabatake, Akira Ogawa, Wataru Nishida, Masahiko Yano, Morito Monden, Kenji Sobue

    Circulation   108 ( 20 )   2524 - 9   2003.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.CIR.0000096482.02567.8C

  • Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo Reviewed

    Kenji Yoshida, Wataru Nishida, Ken'ichiro Hayashi, Yasuyuki Ohkawa, Akira Ogawa, Junken Aoki, Hiroyuki Arai, Kenji Sobue

    Circulation   108 ( 14 )   1746 - 1752   2003.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.CIR.0000089374.35455.F3

  • Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo. Reviewed International journal

    Kenji Yoshida, Wataru Nishida, Ken'ichiro Hayashi, Yasuyuki Ohkawa, Akira Ogawa, Junken Aoki, Hiroyuki Arai, Kenji Sobue

    Circulation   108 ( 14 )   1746 - 52   2003.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.CIR.0000089374.35455.F3

  • Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells Reviewed

    Yasuyuki Ohkawa, Ken'ichiro Hayashi, Kenji Sobue

    Biochemical and Biophysical Research Communications   301 ( 1 )   78 - 83   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0006-291X(02)02965-0

  • Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells. Reviewed International journal

    Yasuyuki Ohkawa, Ken'ichiro Hayashi, Kenji Sobue

    Biochemical and biophysical research communications   301 ( 1 )   78 - 83   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0006-291X(02)02965-0

  • A triad of serum response factor and the GATA and NK families governs the transcription of smooth and cardiac muscle genes Reviewed

    Wataru Nishida, Mako Nakamura, Syunsuke Mori, Masanori Takahashi, Yasuyuki Ohkawa, Satoko Tadokoro, Kenji Yoshida, Kunio Hiwada, Ke N.Ichiro Hayashi, Kenji Sobue

    Journal of Biological Chemistry   277 ( 9 )   7308 - 7317   2002.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M111824200

  • A triad of serum response factor and the GATA and NK families governs the transcription of smooth and cardiac muscle genes. Reviewed International journal

    Wataru Nishida, Mako Nakamura, Syunsuke Mori, Masanori Takahashi, Yasuyuki Ohkawa, Satoko Tadokoro, Kenji Yoshida, Kunio Hiwada, Ken'ichiro Hayashi, Kenji Sobue

    The Journal of biological chemistry   277 ( 9 )   7308 - 17   2002.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M111824200

  • Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids Reviewed

    Ken'ichiro Hayashi, Masanori Takahashi, Wataru Nishida, Kenji Yoshida, Yasuyuki Ohkawa, Akira Kitabatake, Junken Aoki, Hiroyuki Arai, Kenji Sobue

    Circulation Research   89 ( 3 )   251 - 258   2001.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/hh1501.094265

  • Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids Reviewed

    K Hayashi, M Takahashi, W Nishida, K Yoshida, Y Ohkawa, A Kitabatake, J Aoki, H Arai, K Sobue

    CIRCULATION RESEARCH   89 ( 3 )   251 - 258   2001.8

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Books

  • コアヒストンとしてのH2A

    大川 恭行( Role: Sole author)

    メディカルレビュー社  2015.6 

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    Responsible for pages:Vol.22No.2:59-62   Language:Japanese   Book type:Scholarly book

  • DNAメチル化レポーターマウス「メチロー」を用いたメチル化DNAの動態解析法

    上田 潤, 前原 一満, 大川 恭行, 山縣 一夫( Role: Joint author)

    秀潤社  2015.2 

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    Responsible for pages:Vol.33 No.3 :481-489    Language:Japanese   Book type:Scholarly book

  • ヒストンバリアントによるエピゲノム制御

    大川 恭行, 原田 哲仁( Role: Joint author)

    羊土社  2014.8 

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    Responsible for pages:vol.32 No.13:2064-2069    Language:Japanese   Book type:Scholarly book

  • エピジェネティクスで解く細胞運命制御

    大川 恭行, 原田 哲仁( Role: Joint author)

    実験医学 Vol.31 No.13  2013.8 

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    Language:Japanese   Book type:Scholarly book

  • ChIP-seqのためのクロマチン免疫沈降法

    大川 恭行, 小田原 淳, 原田 哲仁( Role: Joint author)

    実験医学 Vol.31 No.4  2013.3 

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    Language:Japanese   Book type:Scholarly book

  • 骨格筋分化における高次クロマチン構造解析

    原田 哲仁, 大川 恭行( Role: Joint author)

    細胞工学 Vol.31 No.8  2012.8 

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    Language:Japanese   Book type:Scholarly book

  • An improved restriction enzyme accessibility assay (REAA) for analyzing changes in chromatin structure in samples of limited cell number.

    OhkawaY., Mallappa C., Dacwag CS., Imbalzano AN.( Role: Joint author)

    2011.10 

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    Language:English   Book type:Scholarly book

  • Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays.

    Ohkawa Y., Mallappa C., Dacwag CS., Imbalzano AN.( Role: Joint author)

    2011.10 

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    Language:English   Book type:Scholarly book

  • 創薬研究を加速する空間オミクス技術

    落合博, 大川恭行( Role: Joint author)

    羊土社 実験医学 増刊  2024.5 

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    Responsible for pages:Vol.42-No.2 63-68   Language:Japanese   Book type:Scholarly book

  • 1細胞エピゲノム

    原田 哲仁,大川 恭行( Role: Joint author)

    ニューサイエンス社 月刊細胞  2023.7 

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    Responsible for pages:Vol.55No.7:12-15 l:71:116-122.   Language:Japanese   Book type:Scholarly book

  • クロマチン構造における転写制御の理解に向けた技術開発

    原田 哲仁,富松 航佑,武 千湄,大川恭行( Role: Joint author)

    公益財団法人金原一郎記念医学医療振興財団・医学書院 生体の科学  2023.6 

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    Language:Japanese   Book type:Scholarly book

  • 少数細胞エピゲノム解析技術の開発

    原田 哲仁,大川 恭行( Role: Joint author)

    2021.12 

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    Responsible for pages:872-876 (2021)   Language:Japanese   Book type:Scholarly book

    DOI: 10.14952/SEIKAGAKU.2021.930872

  • 空間トランスクリプトーム技術の最前線

    沖真弥, 大川恭行( Role: Joint author)

    羊土社 実験医学 2021年9月号  2021.8 

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    Responsible for pages:Vol.39 No.14:2170-2180   Language:Japanese   Book type:Scholarly book

  • ヒストン修飾解析・クロマチン構造解析

    富松航佑, 大川 恭行( Role: Joint author)

    株式会社メディカルドゥ 遺伝子医学MOOK36 2021年  2021.4 

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    Language:Japanese   Book type:Scholarly book

    DOI: 36号45-50

  • シングルセルでのエピゲノム情報の計測技術

    原田 哲仁,大川 恭行( Role: Joint author)

    羊土社 実験医学 2020年5月号  2021.4 

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    Responsible for pages:2020年5月号Vol.38 No.8   Language:Japanese   Book type:Scholarly book

  • ヒストン修飾解析・クロマチン構造解析

    富松航佑, 大川 恭行( Role: Joint author)

    株式会社メディカルドゥ 遺伝子医学MOOK36  2021.4 

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    Responsible for pages:2021年 36号45-50 ISBN978-4-909508-11-9   Language:Japanese   Book type:Scholarly book

  • 1細胞エピゲノム解析技術開発の最前線

    大川 恭行,原田 哲仁,前原 一満( Role: Joint author)

    医歯薬出版株式会社 週刊医学のあゆみ  2021.3 

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    Responsible for pages:Vol278No.10:912-917   Language:Japanese   Book type:Scholarly book

  • scRNA-seqを用いた細胞系譜の軌跡推定

    前原一満, 大川恭行( Role: Joint author)

    羊土社 実験医学 増刊 2020年  2020.12 

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    Responsible for pages:Vol.38-No.20:55-62   Language:Japanese   Book type:Scholarly book

  • 空間オミクス実現に向けたエピゲノム解析技術

    小松 哲郎,大川 恭行( Role: Joint author)

    ニューサイエンス社、月間細胞  2020.5 

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    Language:Japanese   Book type:Scholarly book

  • クロマチン挿入標識法(ChIL)による単一細胞エピゲノム解析

    原田 哲仁,大川 恭行( Role: Joint author)

    羊土社, 実験医学 2019年増刊号  2019.12 

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    Responsible for pages:Vol.37 No.20:178-183   Language:Japanese   Book type:Scholarly book

  • クロマチン構造が規定する骨格筋分化

    小松 哲郎,大川 恭行

    羊土社;実験医学  2018.4 

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    Language:Japanese   Book type:Scholarly book

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Presentations

  • 細胞分化にともなうクロマチン変動メカニズムの解明

    @大川 恭行

    第5回クロマチン動構造班会議  2017.7 

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    Event date: 2017.7

    Language:Japanese  

    Venue:ルスツリゾート(北海道)   Country:Japan  

  • 細胞ポテンシャル測定システムの開発

    大川 恭行

    「CREST1細胞」 CREST領域会議  2017.1 

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    Event date: 2017.1

    Language:Japanese  

    Venue:アクアシティ浜松(静岡)   Country:Japan  

  • The baselines of transcription levels are determined by selective incorporation of histone H3 variants. International conference

    Transcriptional and Epigenetic Control in Stem Cells (J1)  2017.1 

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    Event date: 2017.1 - 2017.7

    Language:English  

    Country:United States  

  • 細胞ポテンシャル測定システムの開発

    大川 恭行

    CREST・さきがけ合同会議  2016.11 

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    Event date: 2016.11

    Language:Japanese  

    Venue:日本科学未来館 未来館ホール 未来館ホール(東京)   Country:Japan  

  • Histone Variants and cell differentiation International conference

    Colorado Chromatin Meeting 2016  2016.8 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 細胞分化にともなうクロマチン変動メカニズムの解明

    大川 恭行

    新学術領域「クロマチン動構造」第四回領域会議  2016.7 

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    Event date: 2016.7

    Language:Japanese  

    Venue:ルスツリゾート   Country:Japan  

  • Cell fate decision on chromatin by MyoD

    2015.12 

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    Event date: 2015.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • マウス胚性幹細胞 (mESC) におけるヘテロクロマチンを介した多分化能維持機構

    林 正康, 小田原 淳, 仙波 雄一郎, 國吉 勇輝, 工藤 健介, 前原 一満, 原田 哲仁, 沖 真弥, 目野 主税, 大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2015.11

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • The Diversity of Mouse Histone H3 Variants Invited International conference

    International Symposium on Chromatin Structure, Dynamics, and Function  2015.8 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • クロマチンコード解読への挑戦 -NGS解析の展開-

    大川 恭行

    第33回内分泌代謝学サマーセミナー  2015.7 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:柳川藩主立花邸 御花   Country:Japan  

  • ヒストンバリアントが制御する骨格筋分化能

    原田 哲仁, 前原 一満, 大川 恭行

    NGS現場の会  2015.7 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば国際会議場   Country:Japan  

  • 細胞分化にともなうクロマチン変動メカニズムの解明

    大川 恭行

    新学術領域研究「クロマチン動構造」第3回班会議  2015.5 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ルスツリゾート   Country:Japan  

  • クロマチン構造にプログラムされた骨格筋分化能~エピゲノム解析で解読するヒストンバーコード~ Invited

    大川 恭行

    千葉大学医学研究院開催セミナー  2015.4 

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉大学 医学部   Country:Japan  

  • The diversity of mouse histone H3 variants. International conference

    Epigenomics (Z2)  2015.3 

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    Event date: 2015.3 - 2015.4

    Language:Japanese  

    Country:Japan  

  • 骨格筋分化能はヒストンH3バリアントの取り込みによって制御されている

    原田 哲仁, 大川 恭行

    日本農芸化学会 2015 大会  2015.3 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山大学津島キャンパス   Country:Japan  

  • N6-methyladenosine is required for the processing of MyoD pre-mRNA for maintaining skeletal muscle differentiation potential. International conference

    Keystone Symposia Chromatin and Epigenetics (C2)  2016.3 

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    Event date: 2015.3

    Language:English  

    Country:Canada  

  • ヒストンバリアントが制御する骨格筋分化能 Invited

    大川 恭行

    国際高等研究所 クロマチン・デコーディング研究会  2015.3 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国際高等研究所   Country:Japan  

  • ヒストンH3バリアントの多様性

    大川 恭行

    ヒストンバリアント研究会  2015.2 

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    Event date: 2015.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京工業大学 すずかけ台キャンパス   Country:Japan  

  • High order chromatin remodeling in skeletal muscle differentiation Invited

    2015.2 

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    Event date: 2015.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 次世代シークエンサーによるエピゲノム解析  ~大規模情報処理パイプラインへの取り組み~ Invited

    大川 恭行

    京都大学学術情報メディアセンターセミナー  2015.1 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都大学学術情報メディアセンター 南館 201マルチメディア講義室   Country:Japan  

  • 異種間ハイブリドーマを用いた全トランスクリプトーム解析

    國吉 勇輝, 前原 一満, 原田 哲仁, 平田 早季, 加藤 倫子, 浦崎 渚, 立花 太郎, 藤田 雅俊, 大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • ヒストンH3バリアントの多様性

    大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:パシフィコ横浜   Country:Japan  

  • 骨格筋分化能はヒストンH3バリアントの取り込みによって制御される

    原田 哲仁, 前原 一満, 佐藤 優子, 木村 宏, 大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:パシフィコ横浜   Country:Japan  

  • 骨格筋芽細胞C2C12細胞に細胞周期特異的に発現する遺伝子の同定

    工藤 健介, 國吉 勇輝, 仙波 雄一郎, 林 正康, 小田原 淳, 前原 一満, 原田 哲仁, 沖 英次, 前原 喜彦, 大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • ヌクレオソーム配置パターンが表現する転写因子機能

    前原 一満, 大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • ヒストンH3バリアントの多様性

    大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • 骨格筋分化能はヒストンH3バリアントの取り込みによって制御される

    原田 哲仁, 前原 一満, 佐藤 優子, 木村 宏, 大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:パシフィコ横浜   Country:Japan  

  • ES細胞におけるChd2クロマチンリモデリング因子の機能解析

    仙波 雄一郎, 小田原 淳, 林 正康, 工藤 健介, 國吉 勇輝, 前原 一満, 原田 哲仁, 立花 太郎, 沖 真弥, 目野 主税, 大川 恭行

    第37回日本分子生物学年会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Country:Japan  

  • クロマチンの機能的エレメントとして働くヌクレオソーム配置パターンの探索

    前原 一満, 大川 恭行

    定量生物学の会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:九州大学 筑紫キャンパス   Country:Japan  

  • 骨格筋分化における空間クロマチン制御へのアプローチ

    大川 恭行

    定量生物学の会  2014.11 

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    Event date: 2014.11

    Language:Japanese  

    Venue:九州大学 筑紫キャンパス   Country:Japan  

  • クロマチン構造制御による骨格筋分化運命機構の解明

    大川 恭行

    第二回 若手による骨格筋細胞研究会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:コープイン京都   Country:Japan  

  • 骨格筋分化におけるヒストンバリアントによるエピゲノム制御 Invited

    大川 恭行

    第87回日本生化学会大会  2014.10 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:国立京都国際会館   Country:Japan  

  • ヒストンバリアントが制御する骨格筋分化能形成

    大川 恭行

    新学術領域研究 「性差構築の分子基盤」第6回領域会議  2014.10 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:舘山寺サゴーロイヤルホテル   Country:Japan  

  • ヒストンバリアントによる遺伝子選択 ~ヒストンバーコード解析の新たな展開~ Invited

    大川 恭行

    第75回日本癌学会学術総会  2014.9 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:パシフィコ横浜   Country:Japan  

  • ヒストンバリアントが制御する骨格筋分化能~ヒストンバーコード説の新たな展開~ Invited

    大川 恭行

    基礎生物学研究所 招聘セミナー講演  2014.9 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:基礎生物学研究所   Country:Japan  

  • Incorporation of Histone H3 Variants Dictates the Lineage Potential of Skeletal Muscle International conference

    FASEB;Science Research Conferences  2014.7 

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    Event date: 2014.7

    Language:English  

    Country:United States  

  • 細胞分化にともなうクロマチン変動メカニズムの解明

    大川 恭行

    第2回「動的クロマチン構造と機能」班会議・若手交流ワークショップ  2014.7 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:十勝サホロリゾート   Country:Japan  

  • 機能を表現するヌクレオソーム配置パターンの探索

    前原 一満, 大川 恭行

    第2回「動的クロマチン構造と機能」班会議・若手交流ワークショップ  2014.7 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:十勝サホロリゾート   Country:Japan  

  • 選択的なヒストンH 3 バリアントの取り込みは骨格筋分化能を決定づける

    原田 哲仁, 前原 一満, 大川 恭行

    第2回「動的クロマチン構造と機能」班会議・若手交流ワークショップ  2014.7 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:十勝サホロリゾート   Country:Japan  

  • 選択的なヒストンH3バリアントの取り組みは骨格筋分化能を決定づける

    原田 哲仁, 大川 恭行

    第66回日本細胞生物学会大会  2014.6 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良県新公会堂   Country:Japan  

  • Exploring nucleosome positioning patterns act as a functional component of chromatin structure International conference

    2014.6 

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    Event date: 2014.6

    Language:English  

    Country:United States  

  • Diversity of histone H3 variants on mouse genome International conference

    2014.6 

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    Event date: 2014.6

    Language:English  

    Country:United States  

  • Incorporation of Histone H3 Variants Dictates Myogenesis International conference

    2014.6 

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    Event date: 2014.6

    Language:English  

    Country:United States  

  • The balance of histone H3 variants around transcription start sites dictates cell differential potential International conference

    Keystone Symposia  2014.2 

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    Event date: 2014.2

    Language:English  

    Country:Japan  

  • The formation of nucleosome positioning patterns flanked by transcription factor binding site International conference

    Keystone Symposia  2014.2 

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    Event date: 2014.2

    Language:English  

    Country:Japan  

  • 骨格筋分化運命を決定するゲノムマーキング機構 Invited

    大川 恭行

    2014.1 

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    Event date: 2014.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学理学E館   Country:Japan  

  • ヒストンH3バリアントの選択的取り込みは骨格筋分化能を支配する

    原田 哲仁, 前原 一満, 大川 恭行

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese  

    Venue:神戸ポートアイランド   Country:Japan  

  • 単一のChIP-Seqデータを使った細胞分化におけるヌクレオソーム配置と転写因子結合の一体的解析

    大川 恭行, 前原 一満

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese  

    Venue:神戸ポートアイランド   Country:Japan  

  • RNA polymerase IIのC末端ドメイン構造の非リン酸化修飾の網羅的解読

    小田原 淳, 前原 一満, 原田 哲仁, 赤司 浩一, 大川 恭行

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese  

    Venue:神戸ポートアイランド   Country:Japan  

  • マウス胚性幹細胞においてChromodomain Helicase DNA binding protein (Chd5)はOct3/4と共役して未分化性の維持に寄与する

    林 正康, 小田原 淳, 原田 哲仁, 前原 一満, 赤司 浩一, 大川 恭行

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese  

    Venue:神戸ポートアイランド   Country:Japan  

  • ヒストンH3バリアントは骨格筋分化能を決定する

    大川 恭行, 原田 哲仁, 前原 一満

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸ポートアイランド   Country:Japan  

  • 骨格筋分化運命決定のメカニズムを追う~クロマチン構造からみる筋形成~ Invited

    大川 恭行

    第一回若手による骨格筋研究会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都大学 iPS細胞研究所   Country:Japan  

  • クロマチン構造から解く遺伝子発現制御機構の解明 Invited

    大川 恭行

    新学術領域研究「動く細胞と秩序」第3回若手の会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ラフォーレ那須(栃木)   Country:Japan  

  • Epigenomic approach unveils cell fate decision Invited

    2013.9 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • ヒストンバリアントによる細胞運命制御 Invited

    大川 恭行

    (独)国立成育研究医療センター招待講演  2013.9 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:(独)国立成育研究医療センター   Country:Japan  

  • High order chromatin regulation in skeletal muscle differentiation

    2013.9 

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    Event date: 2013.9

    Language:English  

    Country:Japan  

  • Histone bariants determine the lineage potential of skeletal muscle International conference

    Fukuoka Internasional Symposium on Genomics & Epigenomics 2013  2013.9 

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    Event date: 2013.9

    Language:English  

    Country:Japan  

  • 性差を構築するクロマチン構造基盤の解明

    大川 恭行

    新学術領域研究「性差構築の分子基盤」第5回領域会議  2013.9 

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    Event date: 2013.9

    Language:Japanese  

    Venue:佐賀   Country:Japan  

  • 生命を形作る道の暗号を解読する

    大川 恭行

    一般公開シンポジウム「DNAをあやつる生物のしくみ」  2013.8 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀   Country:Japan  

  • Exhaustive decoding of RNA polymerase II C-terminal domain non-phosphorylation modification.

    2013.8 

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    Event date: 2013.8

    Language:Japanese  

    Country:Japan  

  • 細胞分化にともなうクロマチン変動メカニズムの解明

    大川 恭行

    新学術領域研究「動的クロマチン構造と機能」第1回班会議  2013.8 

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    Event date: 2013.8

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 細胞分化における高次クロマチン構造制御機構 Invited

    大川 恭行

    千里ライフサイエンスセミナー「エピジェネティクス制御からの生命活動の理解とその展望」  2013.7 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 共局在性を評価する回帰モデルとENCODEデータセットを用いたChlP-seqデータの複数サンプル比較解析法

    前原 一満, 小田原 淳, 原田 哲仁, 大川 恭行

    第65回日本細胞生物学会大会  2013.6 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:愛知   Country:Japan  

  • ヒストンバリアントH3.3による細胞運命決定

    大川 恭行

    第65回日本細胞生物学会大会  2013.6 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:愛知   Country:Japan  

  • ヒストンバリアントによる骨格筋運命決定

    大川 恭行, 原田 哲仁

    第7回日本エピジェネティクス研究会年会  2013.5 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:奈良   Country:Japan  

  • A novel approach to identify mutations responsible for leukemogenesis based on epigenetic inforimation.

    2013.5 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 次世代シークエンサーによる細胞分化運命決定メカニズムの解明 Invited

    大川 恭行

    第56回日本腎臓学会学術総会  2013.5 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • ヒストンバリアントによる骨格筋分化制御機構

    大川 恭行

    第1回ヒストンバリアント研究会  2013.3 

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Chd2 incorporates H3.3 to mark myogenic genes. Invited International conference

    2013.1 

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    Event date: 2013.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 選択的なヒストンバリアントH3.3の取り込みによる造血細胞分化運命決定機構の解明

    小田原 淳, 林 正康, 前原 一満, 原田 哲仁, 赤司 浩一, 大川 恭行

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Chd2依存的なH3.3マーキングが筋発生における骨格筋遺伝子のbivalent geneの形成に必要である

    原田 哲仁, 前原 一満, 小田原 淳, 大川 恭行

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • mRNA新規小胞体標的化機構の分子メカニズムの解明

    梅河内 隆成, 臼井 一馬, 佐藤 哲也, 須山 幹太, 大川 恭行, 山口 政光, 吉田 英樹

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 高次クロマチン構造制御による骨格筋分化制御 Invited

    大川 恭行

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 組織特異的転写因子Ad4BP/SF-1による解糖系遺伝子群の転写を介したグルコース代謝制御

    馬場 崇, 大竹 博之, 佐藤 哲也, 宮林 香奈子, 宍戸 祐里菜, 嶋 雄一, 木村 宏, 大川 恭行, 須山 幹太, 諸橋 憲一郎

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • ショウジョウバエヒストンメチル基転移酵素dG9aは複眼形態形成過程においてEGFR経路の制御に関与する

    嶋路 耕平, 小西 貴大, 田中 伸太朗, 木村 宏, 大川 恭行, 佐藤 哲也, 須山 幹太, 吉田 英樹, 山口 政光

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • マウス亜種間におけるエピゲノム多型の解析

    一柳 健司, 一柳 朋子, 藤 英博, 大川 恭行, 佐々木 裕之

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • CHD5(Chromodomain helicase DNA binding protein 5)はマウスの胚性幹細胞においてH3.1と結合して遺伝子発現を抑制しうる

    林 正康, 小田原 淳, 原田 哲仁, 前原 一満, 赤司 浩一, 大川 恭行

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Cdt1結合蛋白質GRWD1は複製ライセンシングおよび細胞増殖に関わる新規ヒストンシャペロンである

    杉本 のぞみ, 安河内 周平, 前原 一満, 清野 透, 胡桃坂 仁志, 大川 恭行, 藤田 雅俊

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 成獣ライディッヒ細胞における新規Ad4BP/SF-1標的遺伝子の同定

    大竹 博之, 馬場 崇, 佐藤 哲也, 嶋 雄一, 宮林 香奈子, 木村 宏, 大川 恭行, 須山 幹太, 諸橋 憲一郎

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • RNA-seq解析によるフィトクロムBの選択的スプライシング制御の標的遺伝子同定とその機能推定

    柴田 磨己, 四方 明格, 牛島 智一, 大川 恭行, 久原 哲, 松下 智直

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 共局在回帰モデルとENCODEデータセットを介したChIP-seqデータの多サンプル比較解析

    前原 一満, 小田原 淳, 原田 哲仁, 大川 恭行

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • ショウジョウバエ転写因子DREFを中心とした転写制御ネットワーク:DREFの標的としてのHippo経路関連遺伝子の同定

    藤原 俊介, 堀井 健志, 平塚 賢, 大川 恭行, 佐藤 哲也, 須山 幹太, 吉田 英樹, 山口 政光

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • モノクローナル抗体を用いたリン酸化ヒストンH3の解析

    吉見 智彦, 大川 恭行, 東 雅之, 立花 太郎

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • ヒストンバリアントによるゲノムマーキングが骨格筋分化運命決定する Invited

    大川 恭行

    第13回Wakoつくばフォーラム「細胞運命の制御メカニズム」  2012.11 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:茨城 筑波和光ホール   Country:Japan  

  • 遺伝子をすべて見る研究への試み ―多様化するエピゲノム解析― Invited

    大川 恭行

    HPCIワークショップ2012(日本バイオインフォマティクス学会 創薬インフォマティクス研究会)  2012.11 

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    Event date: 2012.10 - 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京 産総研臨海副都心センター   Country:Japan  

  • ヒストンバリアントH3.3取り込みによる骨格筋分化運命決定 Invited

    大川 恭行

    平成24年度遺伝研研究会「染色体ドメインの形成と機能発現機構」  2012.10 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:静岡   Country:Japan  

  • 「Deep sequecerによる実戦的解析 副題:ChIPseq解析からトランスクリプトーム解析でのトラブルシューティング」 Invited

    大川 恭行

    第4回新学術領域研究「性差構築の分子基盤」領域会議  2012.10 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:和歌山   Country:Japan  

  • 遺伝子をすべて見る研究への挑戦

    大川 恭行

    「京」シンポジウム 新生命科学分野開拓とスーパーコンピュータ「京」  2012.8 

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    Event date: 2012.8

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 高次クロマチン構造における細胞分化運命決定

    大川 恭行

    第33回日本炎症・再生医学会  2012.7 

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    Event date: 2012.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 骨格筋分化における高次クロマチン構造制御機構の解明

    大川 恭行

    新学術領域「遺伝情報収納・発現・継承の時空間場」・第5回班会議  2012.6 

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    Event date: 2012.6

    Venue:北海道   Country:Japan  

  • ヒストンバリアントH3.3取り込みによる骨格筋分化運命決定

    大川 恭行

    第6回日本エピジェネティクス研究会年会  2012.5 

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    Event date: 2012.5

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

    細胞分化では幹細胞と呼ばれる細胞は特定の細胞に分化する分化能を持っているとされてきた。一方で、この分化能は遺伝情報が収納されている核内に何らかのマーキング(エピジェネティックメモリー)として存在することが示唆されてきたが、たが、その分子機構は不明であった。
    本研究ではゲノム上の骨格筋形成にかかわる遺伝子群は、細胞が筋肉形成される以前にH3.3と呼ばれるタンパク質で予めマーキングされており、これにより、細胞が筋肉組織を形成する能力を獲得することを明らかにした。また、マーキングの形成は、Chd2・MyoDの二つのタンパク質が行っていることを明らかにした。
    本研究成果は、遺伝子のマーキングをモニタリングすることで、細胞が将来どの組織になるのか予測を可能としたものであり、再生医療の実用化にとって極めて有効な指標と期待される。

  • 次世代シークエンサーを用いた高次クロマチン構造解析 Invited

    大川 恭行

    大阪大学生命機能研究科コロキアム  2012.1 

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    Event date: 2012.1

    Venue:大阪   Country:Japan  

  • Chd-2 dependent deposition of H3.3 is required for myogenic cell fate. International conference

    KEYSTONE SYMPOSIA  2012.1 

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    Event date: 2012.1

    Country:United States  

  • Control of gene expression through the phosphorylation of Ser2 and Ser5 of RNAPⅡ: A combined analysis for ChIPseq and RNAseq. International conference

    2012.1 

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    Event date: 2012.1

    Venue:コロラド,USA   Country:United States  

  • The deposition of histone varients is the basis of chromatin structual changes in cell fate decision.

    Yasuyuki Ohkawa, Jun Odawara, Akihito Harada

    2011.12 

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    Event date: 2011.12

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Control of gene expression through the phosphorylation of Ser2 and Ser5 of RNAPⅡ: A combined analysis for ChIPseq and RNAseq.

    第34回日本分子生物学会年会  2011.12 

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    Event date: 2011.12

    Venue:神奈川   Country:Japan  

  • Visualization for nuclear distribution of PPARδ in myoblast.

    第34回日本分子生物学会年会  2011.12 

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    Event date: 2011.12

    Venue:神奈川   Country:Japan  

  • Chd-2 dependent deposition of H3.3 is crucial for Brg1 recruitment in myogenesis.

    Akihito Harada, Jun Odawara, Kazumitu Maehara, Tomohiko Yoshimi, Saori Yoshimura, Taro Tachibana, Hitoshi Kurumizaka, Hiroshi Kimura, Yasuyuki Ohkawa

    2011.12 

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    Event date: 2011.12

    Country:Japan  

  • Chd-2 dependent deposition of H3.3 is crucial for Brg1 recruitment in myogenesis.

    Akihito Harada, Jun Odawara, Kazumitu Maehara, Tomohiko Yoshimi, Saori Yoshimura, Taro Tachibana, Hitoshi Kurumizaka, Hiroshi Kimura, Yasuyuki Ohkawa

    2011.12 

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    Event date: 2011.12

    Country:Japan  

  • 次世代シークエンサーを用いた高次クロマチン構造解析

    大川 恭行

    新学術領域研究「遺伝情報場」 第2回異分野融合workshop  2011.11 

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    Event date: 2011.11

    Venue:大阪   Country:Japan  

  • 次世代シークエンサーを用いた高次クロマチン構造解析 Invited

    大川 恭行

    「サイエンス交流会」次世代シークエンサーをもちいた最先端ゲノム解析  2011.7 

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    Event date: 2011.7

    Venue:京都   Country:Japan  

  • 次世代シークエンサーによる細胞分化運命決定メカニズムの解明 Invited

    大川 恭行

    岡山大学 守屋研究室 セミナー  2011.7 

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    Event date: 2011.7

    Venue:岡山   Country:Japan  

  • 分化遺伝子選択における時空間制御機構の解明

    大川 恭行

    新学術領域研究「遺伝情報場」班会議  2011.6 

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    Event date: 2011.6

    Venue:北海道   Country:Japan  

  • Spatial re-organization of regulatory sequences temporally controls gene expression.

    Yasuyuki Ohkawa, Akihito Harada, Anthony Imbalzano

    2010.12 

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    Event date: 2010.12

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 骨格筋分化へ運命決定するクロマチンリモデリング因子Chd2によるゲノムマーキング機構

    大川 恭行

    H22年度遺伝研研究会「細胞核超分子複合体の動態とその機能」  2010.10 

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    Event date: 2010.10

    Venue:静岡   Country:Japan  

  • 高次クロマチン構造変換が決定する細胞分化運命

    大川 恭行

    分子細胞生物学セミナー  2010.7 

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    Event date: 2010.7

    Venue:北海道   Country:Japan  

  • Chd2 determines myogenic cell fate International conference

    The 8th Stem Cell Research Symposium  2010.5 

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    Event date: 2010.5

    Country:Japan  

  • Spatial re-organization of regulatory sequences in myogenesis.

    Yasuyuki Ohkawa, Akihito Harada and Anthony Imbalzano

    2009.12 

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    Event date: 2009.12 - 2010.12

    Country:Japan  

  • Genomic clustering accompanies cellular differentiation to temporally control gene expression International conference

    The 8th International Workshop on advanced Genomics [Expansion of Genome Science]  2009.6 

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    Event date: 2009.6

    Country:Japan  

    Genomic clustering accompanies cellular differentiation to temporally control gene expression

  • 連続免疫染色法による高解像度空間オミクスの開発 Invited

    大川恭行

    2024.2 

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    Event date: 2024.2

    Language:Japanese  

    Venue:東京大学医科学研究所 本館1階講堂   Country:Japan  

  • 組織形成を理解するための単一細胞マルチオミクスの開発 Invited

    大川恭行

    創薬医学講座  2024.2 

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    Event date: 2024.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 組織形成を理解するための単一細胞マルチオミクスの開発 Invited

    原田 哲仁、富松航佑、藤井健、大川恭行

    第46回日本分子生物学会  2023.11 

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    Event date: 2023.11 - 2023.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • Developing single-cell multi-omics to understand tissue formation Invited International conference

    Yasuyuki Ohkawa

    2023.11 

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • マルチオミクスの開発と実践 Invited

    大川恭行

    東京大学薬学系研究科大学院講義  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 組織形成を理解するための単一細胞マルチオミクスの開発 Invited

    大川恭行

    奈良県立医科大学講演  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • Comprehensive Analysis of Signal Transduction Activation Pathways through Sequential Immunostaining International conference

    Yasuyuki Ohkawa

    Single Cell Genomics Conference 2023  2023.10 

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    Event date: 2023.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Switzerland  

  • 遺伝子発現制御を包括的に解析する技術の開発 Invited

    大川恭行

    2023年度国立遺伝学研究所クロマチン研究会(NIG-JOINT)  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立遺伝学研究所   Country:Japan  

  • トランスクリプトミクスで迫る細胞分化能 Invited

    大川恭行

    大阪大学産業科学研究所セミナー  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大阪大学 産業科学研究所   Country:Japan  

  • 組織形成を理解するための単一細胞マルチオミクスの開発

    大川恭行

    <MBL> 第34回 高遠シンポジウム  2023.8 

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    Event date: 2023.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京晴海 L stay & grow   Country:Japan  

  • 空間オミクスの現状と高度化

    大川恭行

    令和4年度BINDSシンポジウム  2022.8 

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    Event date: 2023.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:一橋大学一橋講堂+WEB   Country:Japan  

  • トランスクリプトミクスによる筋再生過程の高深度解析 Invited

    大川恭行

    第9回日本筋学会学術集会/第10回筋ジストロフィー医療研究会  2023.8 

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    Event date: 2023.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千里ライフサイエンスセンター   Country:Japan  

  • クロマチン構造レベルで理解するゲノムワイドな遺伝子発現制御 Invited

    大川恭行

    生物科学特別講義  2023.5 

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    Event date: 2023.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 骨格筋幹細胞の運命決定を遺伝子発現制御から理解する ~単一細胞エピゲノム解析から空間マルチオミクスへの展開~ Invited

    大川恭行

    生物科学セミナー  2023.5 

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    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学   Country:Japan  

  • Development of spatial multi-omics for understanding skeletal muscle aging Invited International conference

    Yasuyuki Ohkawa

    1st Symposium on "Skeletal muscle cells in Growth and Disease"  2023.5 

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    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 単一細胞マルチオミクスによる骨格筋分化制御機構の解明 Invited

    大川恭行

    第6回運動器と健康研究会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Spatial multi-omics for understanding chromatin dynamics Invited

    2023.1 

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    Event date: 2023.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • データから変化を取り出す新たな単一細胞解析技術 Invited

    大川恭行

    【富士フイルム】講演  2023.1 

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    Event date: 2023.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Single-cell multi-targeted chromatin integration labeling technology for understanding chromatin dynamics Invited International conference

    Yasuyuki Ohkawa

    CSHA meeting on Integrative Epigenetics in Plants  2022.12 

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    Event date: 2022.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 空間オミクス技術によるクロマチン構造制御メカニズムの解明 Invited

    大川恭行

    第95回日本生化学会大会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋国際会議場   Country:Japan  

  • 細胞恒常性を担うシグナルと遺伝子発現の制御 Invited

    大川恭行

    第16回日本臨床ストレス応答学会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:完全Web開催   Country:Japan  

  • 高深度解析による全ゲノムレベルの単一細胞オミクスへの挑戦 Invited

    大川恭行

    2022.10 

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    Event date: 2022.10

    Language:Japanese  

    Venue:大阪府立国際会議場   Country:Japan  

  • 単一細胞軌跡追跡によるクロマチンダイナミクスの解明 Invited

    大川恭行

    2022年度国立遺伝学研究所クロマチン研究会  2022.10 

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    Event date: 2022.10

    Language:Japanese  

    Venue:国立遺伝研究所   Country:Japan  

  • Chromatin regulation during skeletal muscle regeneration Invited

    Yasuyuki Ohkawa

    2022.10 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 骨格筋分化のクロマチンダイナミクス Invited

    大川恭行

    日本遺伝学会第94回大会  2023.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:北海道大学工学部   Country:Japan  

  • Spatial multi-omics for understanding gene expression regulated by cell-cell interaction Invited International conference

    Yasuyuki Ohkawa

    Japan-UK Regulation through Chromatin Conference  2022.8 

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    Event date: 2022.8

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Lesotho  

  • 空間オミクスによる骨格筋組織老化機序の解明 Invited

    大川恭行

    第8回日本筋学会学術集会  2022.8 

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    Event date: 2022.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京大学伊藤国際学術研究センター   Country:Japan  

  • クロマチン解析のための新技術開発の現状と今後の展開 Invited

    大川恭行

    第15回日本エピジェネティクス研究会年会  2022.6 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学医学部百年講堂   Country:Japan  

  • 空間マルチオミクスの展開~エピゲノム, トランスクリプトームからプロテオームの空間計測の試み~ Invited

    大川恭行

    がん研セミナー  2021.11 

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    Event date: 2021.11 - 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:がん研究会がん研究所   Country:Japan  

  • 骨格筋再性能を制御するクロマチン構造等その破綻

    大川恭行

    第94回日本生化学会大会  2021.11 

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    Event date: 2021.11 - 2022.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • Identification and Analysis of Minor Histone Variants Invited International conference

    Yasuyuki Ohkawa

    EMBO Workshop Physiology and function of histone variants  2021.9 

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    Event date: 2021.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ⾻格筋特異的なヒストンが構成するクロマチン構造の解明

    大川恭行

    第8回骨格筋生物学会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • H3組成依存的なクロマチン構造の制御機構の解明

    大川恭行

    第38回染色体WS・第19回核ダイナミクス研究会  2021.1 

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    Event date: 2021.1

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • クロマチンダイナミクスの理解に向けた同時マルチオミクスの開発 Invited

    大川恭行

    『配偶子インテグリティの構築』『全能性プログラム』合同公開シンポジウム 2020  2021.5 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • クロマチンダイナミクスの理解に向けた同時マルチオミクスの開発

    大川恭行

    第43回日本分子生物学会  2020.12 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • トランスクリプトミクスによる骨格筋細胞分化能の解明 Invited

    大川恭行

    第19回日本再生医療学会総会  2020.8 

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    Event date: 2020.8 - 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • Chromatin integration labeling Technology for expanding multi-omics Invited

    2020.6 

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    Event date: 2020.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 単一細胞マルチオミクスに向けたクロマチン挿入標識法の開発 Invited

    大川恭行

    第19回日本再生医療学会総会  2022.5 

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    Event date: 2020.5 - 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • トランスクリプトミクスで迫る細胞分化能 Invited

    大川恭行

    とっとりバイオフロンティア 招聘セミナー  2020.1 

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    Event date: 2020.1

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:とっとりバイオフロンティア   Country:Japan  

  • Development of chromatin integration labeling technology for single cell multiomics

    2019.12 

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    Event date: 2019.12

    Language:Japanese  

    Country:Japan  

  • マルチオミクス時代に向けた新規NGS技術の開発 Invited

    大川恭行

    第42回日本分子生物学会年会バイオテクノロジーセミナー  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場   Country:Japan  

  • 抗体遺伝子配列の決定法 Invited

    大川恭行

    第42回日本分子生物学会年会 フォーラム  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場   Country:Japan  

  • Chromatin Integration Labeling Technology for Expanding Multi-Omics Invited

    2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 遺伝子の発現されやすさはどのように決まるのか?~クロマチンが規定する遺伝子発現制御能力~ Invited

    大川恭行

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:マリンメッセ福岡   Country:Japan  

  • Spatial epigenomics approached by chromatin integration labeling technology

    Trans-Omics for Advanced Medical Sciences  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Country:Japan  

  • クロマチン挿入法による単一細胞エピゲノム解析 Invited

    大川恭行

    日本人類遺伝学会第64回大会  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎ブリックホール   Country:Japan  

  • Chromatin integration labelling technology for expanding multi-omics Invited

    2019.10 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 幹細胞の分化能を司るクロマチン構造の解明と周辺技術開発

    大川恭行

    第1回 PHILOSOPHY  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Venue:MSD株式会社   Country:Japan  

  • Chromatin integration labelling Technology for expanding multi-omics International conference

    Yasuyuki Ohkawa

    EMBO Symposia: Multi-Omics  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Germany  

  • The Function of Histone H3.3 Subvariants in Skeletal Muscle Regeneration Approached from Spatial Transcriptomics Invited International conference

    Yasuyuki Ohkawa

    2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 空間トランスオミクス技術の開発

    大川恭行

    新学術領域研究「代謝統合オミクス」第3回班会議  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学コラボステーションⅠ   Country:Japan  

  • ヒストンバリアントによる転写能調節機構の解明

    大川恭行

    新学術領域研究「クロマチン潜在能」第2回班会議  2019.6 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ホテル竹島   Country:Japan  

  • Chromatin integration labelling technology for expanding multi-omics International conference

    2019.5 

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    Event date: 2019.5 - 2020.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 分析化学において"AI・ビッグデータ"の使い道はあるのか?

    大川恭行

    第79回分析化学討論会  2019.5 

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    Event date: 2019.5 - 2021.5

    Language:Japanese  

    Venue:北九州国際会議場   Country:Japan  

  • クロマチン組成変化から考える細胞分化能制御 ~トランスクリプトミクスの新たな展開~

    大川恭行

    第362回 発生研セミナー  2019.4 

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    Event date: 2019.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:熊本大学発生医学研究所   Country:Japan  

  • 骨格筋再生におけるヒストン転換

    @大川 恭行

    第7回骨格筋生物学研究会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋市立大学 山の畑(滝子)キャンパス   Country:Japan  

  • Transcriptional Plasticity regulated by novel Histone H3 Varigants Invited

    2019.2 

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    Event date: 2019.2

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 空間トランスクリプトミクスで解明する骨格筋再生

    @大川 恭行

    第41回日本分子生物学会年会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:パシフィコ横浜   Country:Japan  

  • Histone composition in chromatin regulates skeletal muscle regeneration International conference

    The 6th Society of Skeletal Muscle Cells  2018.11 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 免疫沈降をしない1細胞エピゲノム解析技術の開発

    @大川 恭行

    第91回日本生化学会学大会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:国立京都国際会館   Country:Japan  

  • 骨格筋分化・再生司るクロマチン構造制御機構の解明

    @大川 恭行

    日本筋学会第4回学術集会  2018.8 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:川崎医科大学   Country:Japan  

  • クロマチン組成変化から考える細胞分化能制御~トランスクリプトミクスの新たな展開~ Invited

    @大川 恭行

    東京大学理学部研究セミナー  2018.7 

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    Event date: 2018.7 - 2019.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京大学理学部3号館   Country:Japan  

  • Myogenic chromatin structure is formed with the novel histone H3 variant. International conference

    @Ohkawa Yasuyuki

    EMBO Workshop Histone Vriants  2017.9 

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    Event date: 2018.6 - 2017.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Germany  

  • 1細胞エピゲノム解析技術の開発

    @大川 恭行

    第12回日本エピジェネティクス研究会年会  2018.5 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道⽴道⺠活動センター   Country:Japan  

  • 遺伝子発現能から迫る骨格筋再生機構の解明~トランスクリプトミクスによるアプローチ~ Invited

    @大川 恭行

    NCNP神経研究所セミナー  2018.5 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:国立精神神経医療研究センター   Country:Japan  

  • ChILT- an Epigenomic Profiling for Single Cell Analysis Invited

    2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ヒストンH3の選択による細胞分化制御機構 ~トランスクリプトミクスによるアプローチ~  Invited

    @大川 恭行

    よこはまNMR研究会  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:理化学研究所横浜事業所 交流棟ホール   Country:Japan  

  • ヒストンH3の選択による細胞分化制御機構~トランスクリプトミクスによるアプローチ~ Invited

    @大川 恭行

    群馬大学生調研セミナー  2018.2 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:群馬大学昭和キャンパス(群馬)   Country:Japan  

  • 1細胞エピゲノム解析技術の開発 Invited

    @大川 恭行

    日本がん分子標的治療学会TRワークショップ  2018.1 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:都市センターホテル(東京)   Country:Japan  

  • ゲノムから遺伝子が選ばれる仕組み Invited

    @大川 恭行

    クロマチン一般公開シンポジウム  2018.1 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:早稲田大学 井深大記念ホール   Country:Japan  

  • ヒストンバリアントによる細胞運命決定機構 Invited

    @大川 恭行

    京都大学 学術講演会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都大学(京都)   Country:Japan  

  • 次世代スパースタープログラムの4年間 Invited

    大川 恭行

    新学術領域「動的クロマチン構造と機能」の若手の会シンポジウム  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:早稲田大学西早稲田キャンパス(東京)   Country:Japan  

  • ヒストンH3バリアントで制御される組織特異的構造

    @大川 恭行

    2017年度生命科学系学会合同年次大会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸ポートアイランド(兵庫)   Country:Japan  

  • Tissue-specific Chromatin Structures According to Histone H3 Variants . Invited International conference

    @Ohkawa Yasuyuki

    2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Korea, Republic of  

  • ヒストンバリアントによる組織特異的クロマチン構造の形成 Invited

    @大川 恭行

    日本遺伝学会第89回大会  2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山大学一般教育棟および創立五十周年記念館(岡山)   Country:Japan  

  • ChILT - an Immunoprecipitation-free Epigenome Profiling Technology. International conference

    @Ohkawa Yasuyuki

    2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Germany  

  • 骨格筋再生の核内プログラム~トランスクリプトミクス解析の新たな展開~ Invited

    @大川 恭行

    運動器科学研究会  2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大和ミュージアム(広島)   Country:Japan  

  • Tissue-specific Chromatin Structures According to Histone H3 Variants Invited

    2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Myogenic Chromatin Structure Is Formed with the Histone H3 Variant H3mm7

    @Ohkawa Yasuyuki

    Gordon Research Conference  2017.6 

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    Event date: 2017.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Italy  

  • ChiLT-an Immunoprecipitation-free Epigenome Profiling Technology International conference

    @Ohkawa Yasuyuki

    Single Cell Omics (E3)  2017.5 

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    Event date: 2017.5

    Language:English  

    Country:Sweden  

  • ヒストンH3バリアントによる骨格筋特異的クロマチン構造制御

    @大川恭行

    第11回日本エピジェネティクス研究会年会  2017.5 

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    Event date: 2017.5

    Language:Japanese  

    Venue:一橋大学 一橋講堂   Country:Japan  

  • 骨格筋分化のエピゲノム制御を捉える

    大川 恭行

    2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:東京大学駒場キャンパス(東京)   Country:Japan  

  • 骨格筋再生を制御するゲノムワイドな遺伝子制御機構~ヒストンの組成変化が拓く新たなエピゲノム制御~ Invited

    @大川 恭行

    PROS学術シンポジウム  2017.2 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:愛媛大学医学部40周年記念講堂(愛媛)   Country:Japan  

  • ヒストンH3バリアントの選択による転写基底レベル調節機構

    大川 恭行

    第39回日本分子生物学会年会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • ヒストンH3バリアントの選択による転写基底レベル調節機構

    大川 恭行

    第39回日本分子生物学会年会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese  

    Country:Japan  

  • トランスクリプトミクスで解析する骨格筋形成

    大川 恭行

    第4回若手による骨格筋細胞研究会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ウィンクあいち(愛知)   Country:Japan  

    選択的な遺伝子発現が組織形成を決定する。例えば、発生、再生の過程では、ゲノム上に存在する2-3万もの遺伝子から数千の遺伝子が選択的に且つ段階的に秩序だって発現する。
    一方で、遺伝子ごとに異なる発現制御機構を転写から表現型の形成に至るまで網羅的に解析することは困難であり全貌はいまだ明らかではない。そこで、我々はゲノム上の全遺伝子の発現制御機構の包括的な解析による骨格筋形成メカニズム解明を目指している。これまでに我々は、骨格筋遺伝子をコードするDNAが特定のヒストン(H3.3)によりマーキング(ゲノムマーキング)されることが、骨格筋分化の起点となることを明らかにした。その後このマーキングに関わる多様なヒストン群を同定し新たな転写調節機構が明らかにしつつある。近年進展の目覚ましいゲノムワイドな解析技術の紹介を交えながら、骨格筋分化・再生およびその破たんにおけるゲノム上での遺伝子の選択、そして発現調節を中心に議論したい。

  • トランスオミクス研究の新展開―全ての遺伝子をみるー Invited

    大川 恭行

    第48回藤田学園医学会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:藤田学園フジタホール   Country:Japan  

  • トランスクリプトミクスで解析する骨格筋形成

    大川 恭行

    第2回日本筋学会学術集会  2016.8 

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    Event date: 2016.8

    Language:Japanese  

    Venue:国立研究開発法人国立精神・神経医療研究センター   Country:Japan  

  • 筋分化および形成破綻におけるエピゲノム制御 Invited

    大川 恭行

    第1回日本筋学会学術集会  2015.8 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立精神・神経医療研究センター 研修棟ユニバーサルホール   Country:Japan  

  • Incorporation of Histone H3 Variants Dictates the Lineage Potential of Skeletal Muscle. International conference

    Transcriptional and Epigenetic Influences on Stem Cell States (C9)  2015.3 

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    Event date: 2015.3

    Language:Japanese  

    Country:Japan  

  • 次世代シークエンサーを用いた遺伝子発現解析~クロマチン構造解析から発現プロファイリングまで~

    大川 恭行

    新学術領域研究「性差構築の分子基盤」第2回領域会議・公開研究会議  2010.12 

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    Event date: 2010.12

    Venue:神奈川   Country:Japan  

  • ES specific transcription factors functions with the WI/SNF chromatin remodeling factor CHD2 in Embryonic stem cells.

    第33回日本分子生物学会年会・第83回日本生化学会大会合同大会  2010.12 

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    Event date: 2010.12

    Venue:兵庫   Country:Japan  

  • Chd2 interacts with H3.3 to determine cell fate in myogenesis.

    Akihito Harada, Jun Odawara, Hitoshi Kurumizaka, Taro Tachibana, Yasuyuki Ohkawa

    2010.12 

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    Event date: 2010.12

    Country:Japan  

  • Chd2 interacts with H3.3 to determine cell fate in myogenesis.

    Akihito Harada, Jun Odawara, Hitoshi Kurumizaka, Taro Tachibana, Yasuyuki Ohkawa

    2010.12 

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    Event date: 2010.12

    Country:Japan  

  • A SWI/SNF family member, CHD2 commits undifferentiated cells into myogenesis by selective marking with Histone3.3 incorporation.

    Akihito Harada, Saori Yoshimura, Tomohiko Yoshimi, Taro Tachibana, Yasuyuki Ohkawa

    2009.12 

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    Event date: 2009.12

    Country:Japan  

  • The purification and functional analysis of CHD2 complex.

    Jun Odawara, Akihito Harada, Kouichi Akashi, Yasuyuki Ohkawa

    2009.12 

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    Event date: 2009.12

    Country:Japan  

  • CHD2は骨格筋分化の運命決定に関与する

    原田哲仁、吉村小緒利、立花太郎、大川恭行

    2009年度日本農芸化学会関西・中四国・西日本支部 合同沖縄大会  2009.10 

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    Event date: 2009.10 - 2010.10

    Venue:沖縄   Country:Japan  

  • Skeletal Muscle specification by SWI/SNF ATPase CHD2

    Akihito Harada, Tomohiko Yoshimi, Taro Tachibana, Yasuyuki Ohkawa

    2009.6 

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    Event date: 2009.6

    Country:Japan  

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MISC

  • CHD2クロマチンリモデリング因子変異による無秩序遺伝子発現機構の解明.

    大川 恭行

    文部科学省科学研究費補助金 特定領域研究「がん」4領域. 平成21年度 研究報告書   2010.7

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    Language:Japanese   Publishing type:Internal/External technical report, pre-print, etc.  

  • 細胞分化における高次遺伝子発現制御機構ネットワークの解明.

    大川 恭行

    文部科学省科学研究費補助金 特定領域研究「ゲノム」4領域. 平成21年度 研究報告書   2010.3

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    Language:Japanese   Publishing type:Internal/External technical report, pre-print, etc.  

  • 細胞分化における高次遺伝子発現制御機構ネットワークの解明.

    大川 恭行

    文部科学省科学研究費補助金 特定領域研究「ゲノム」4領域. 平成20年度 研究報告書   2008.3

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    Language:Japanese   Publishing type:Internal/External technical report, pre-print, etc.  

  • CHD2クロマチンリモデリング因子変異による無秩序遺伝子発現機構の解明.

    大川 恭行

    文部科学省科学研究費補助金 特定領域研究「がん」4領域.   2008.3

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    Language:Japanese   Publishing type:Internal/External technical report, pre-print, etc.  

  • Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers.

    de la Serna IL, Ohkawa Y, Imbalzano AN.

    Nat Rev Genet.   2006.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Works

Industrial property rights

Patent   Number of applications: 5   Number of registrations: 2
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Molecular Biology Society of Japan

  • Japan Society for Biology

  • Japanese Society for bioinformatics

  • Japanese Society for Epigenetics

  • Structural Epigenomics Association

  • about The Japanese Biochemical Sicuety

  • ​Japan Muscle Society

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Committee Memberships

  • 日本エピジェネティクス研究会   賞等選考委員会   Domestic

    2021.4 - Present   

  • Executive   Domestic

    2021.4 - 2022.3   

Academic Activities

  • オーガナイザー International contribution

    ( オンライン ) 2022.1

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    Type:Competition, symposium, etc. 

  • 国際事業委員会書面審査・書面評価委員

    Role(s): Review, evaluation

    日本学術振興会  2021.7 - 2023.6

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    Type:Scientific advice/Review 

  • 特別研究員等審査会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2021.7 - 2023.6

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    Type:Scientific advice/Review 

  • 卓越研究員候補者選考委員会書面審査委員

    Role(s): Review, evaluation

    日本学術振興会  2021.7 - 2023.6

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    Type:Scientific advice/Review 

  • オーガナイザー

    第38 回 染色体ワークショップ 第19 回 核ダイナミクス研究会  ( オンライン ) 2021.1

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • 科学研究費助成事業審査委員

    Role(s): Review, evaluation

    日本学術振興会  2020.11 - 2021.3

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    Type:Scientific advice/Review 

  • 実験医学別冊 最強のステップUPシリーズ

    2020.4 - 2020.12

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    Type:Academic society, research group, etc. 

  • 科学研究費助成事業審査委員

    Role(s): Review, evaluation

    日本学術振興会  2019.11 - 2020.3

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    Type:Scientific advice/Review 

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:43

  • 科学研究費助成事業審査委員

    Role(s): Review, evaluation

    日本学術振興会  2018.11 - 2019.3

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    Type:Scientific advice/Review 

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:37

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:26

  • 座長(Chairmanship)

    第4回若手による骨格筋細胞研究会  ( うぃんくあいち(愛知) ) 2016.11

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:21

  • 事務局

    第三回若手による骨格筋細胞研究会  ( 九州大学 病院キャンパス コラボステーションⅠ-3F ) 2015.11

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    Type:Competition, symposium, etc. 

    Number of participants:70

  • 座長(Chairmanship)

    第1回日本筋学会学術集会  ( 国立精神・神経医療研究センター 研修棟ユニバーサルホール ) 2015.8

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2015

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:11

  • オーガナイザー

    第87回日本生化学会大会  ( 国立京都国際会館 ) 2014.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第2回「動的クロマチン構造と機能」班会議・若手交流ワークショップ  ( 十勝サホロリゾート ) 2014.7

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2014

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:6

  • オーガナイザー

    第86回日本生化学会大会  ( パシフィコ横浜 ) 2013.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    新学術領域「遺伝情報収納・発現・継承の時空間場」・第5回班会議  ( 北海道 ) 2012.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第10回幹細胞シンポジウム  ( 淡路夢舞台国際会議場 ) 2012.5 - 2012.6

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    Type:Competition, symposium, etc. 

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Research Projects

  • 骨格筋の老化を司るエピコードの解読

    Grant number:24H02323  2024 - 2029

    日本学術振興会・文部科学省  科学研究費助成事業  学術変革領域研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 結合オミクスによる骨格筋組織再生機序の解明

    Grant number:23H00372  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • カイコ昆虫モダリティによる低価格な国産組換えワクチンに関する研究開発

    2022.12 - 2025.3

    日本医療研究開発機構 

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    Authorship:Coinvestigator(s) 

  • 空間オミクス解析の支援

    2022.6 - 2027.3

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    Authorship:Principal investigator 

  • 将来の創薬を念頭に置いた心不全発症・増悪リスク層別化マーカーの開発

    2022.4 - 2025.3

    日本医療研究開発機構 

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    Authorship:Coinvestigator(s) 

  • 空間マルチオミクスでアプローチする初期胚における細胞運命決定機序の理解

    2022.4 - 2024.3

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    Authorship:Principal investigator 

  • ⼼不全治療における次世代医療基盤確⽴に向けたゲノム・オミックス解析とデータシェアリング

    2022.4 - 2023.3

    日本医療研究開発機構 

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    Authorship:Coinvestigator(s) 

  • 組織内少数細胞を標的としたマルチオミックス技術の開発

    2022.4 - 2023.3

    日本医療研究開発機構 

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    Authorship:Coinvestigator(s) 

  • 空間オミクス解析の支援

    2022 - 2026

    AMED-BINDS

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    Authorship:Principal investigator  Grant type:Contract research

  • カイコ昆虫モダリティによる低価格な国産組換えワクチンに関する研究開発

    2022 - 2024

    ワク チン•新規モダリティ研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 将来の創薬を念頭に置いた心不全発症・増悪リスク層別化マーカーの開発

    2022 - 2024

    循環器疾患・糖尿病等生活習慣病対策実用化研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 非破壊的に生細胞のトランスクリプトームの経時変化を追跡する技術の開発

    Grant number:22K19275  2022 - 2023

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 空間マルチオミクスでアプローチする初期胚における細胞運命決定機序の理解

    Grant number:22H04676  2022 - 2023

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ⼼不全治療における次世代医療基盤確⽴に向けたゲノム・オミックス解析とデータシェアリング

    2022

    ゲノム医療実現バイオバンク利活用プログラム

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 感染症対策のための遺伝子解析プラットフォーム構築事業

    2022

    令和4年度実施事業「大学発ベンチャー事業シーズ育成支援プログラム」第Ⅵ期 九大ギャップファンド

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 日本人集団ゲノムワイドクロマチン相互作用情報と構造多型との関連解析と疾患要因探索

    2021.4 - 2024.3

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    Authorship:Coinvestigator(s) 

  • 高転写状態解明に向けた空間マルチオミクス解析技術の開発

    2021.4 - 2023.3

    日本学術振興会 

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    Authorship:Principal investigator 

  • 高転写状態解明に向けた空間マルチオミクス解析技術の開発

    Grant number:21H00232  2021 - 2022

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 全細胞オミクスによる骨格筋組織を構築するシステムの解明

    2020.4 - 2023.3

    日本学術振興会 

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    Authorship:Principal investigator 

  • 組織内の核内ゲノム構造を単一細胞レベルで高解像度に解析する技術の開発

    2020.4 - 2022.3

    日本学術振興会 

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    Authorship:Principal investigator 

  • 高深度解析を可能とする単一細胞空間オミクス技術の開発

    2020.4 - 2022.3

    日本学術振興会 

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    Authorship:Principal investigator 

  • 全細胞オミクスによる骨格筋組織を構築するシステムの解明

    Grant number:20H00456  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 研究開発課題名:精緻エピゲノム解析技術開発とIRUD未解明症例への応用 【分担者課題名】組織内少数細胞を標的としたマルチオミックス技術の開発

    2020 - 2022

    AMED

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 高深度解析を可能とする単一細胞空間オミクス技術の開発

    Grant number:20H04846  2020 - 2021

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 組織内の核内ゲノム構造を単一細胞レベルで高解像度に解析する技術の開発

    Grant number:20K21398  2020 - 2021

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 高転写状態獲得を理解するためのエピゲノム・トランスクリプトーム解析技術の開発

    2019.6 - 2021.3

    日本学術振興会 

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    Authorship:Principal investigator 

  • 単一細胞遺伝子解析によるヒト造精機能障害の分子機構の解明

    2019.4 - 2022.3

    日本学術振興会 

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    Authorship:Coinvestigator(s) 

  • 「個性」創発に至る次世代継承エピゲノム修飾とその脳内表現

    2019.4 - 2022.3

    日本学術振興会 

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    Authorship:Coinvestigator(s) 

  • 高転写状態獲得を理解するためのエピゲノム・トランスクリプトーム解析技術の開発

    Grant number:19H05244  2019 - 2020

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究(研究領域提案型)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 空間トランスオミクス技術の開発

    2018.4 - 2020.3

    日本学術振興会 

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    Authorship:Principal investigator 

  • 可逆的な老化における可塑的なエピゲノムが制御するゲノム安定性の理解

    2018 - 2022

    日本学術振興会  国際共同研究事業 英国との国際共同研究プログラム(JRPs-LEAD with UKRI)

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    Authorship:Principal investigator  Grant type:Joint research

  • 空間トランスオミクス技術の開発

    Grant number:18H04802  2018 - 2019

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • トランスオミクス情報を一度に獲得する手法の開発

    2017.7 - 2019.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • クロマチン組成が規定する骨格筋分化制御機構の解明

    2017.4 - 2020.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • クロマチン組成が規定する骨格筋分化制御機構の解明

    Grant number:17H03608  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • B細胞の免疫制御作用を起点とする自己免疫病態の理解とその応用 【分担者課題名】 制御性 B 細胞のトランスクリプトーム解析

    2017 - 2019

    AMED-CREST

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 抗Brmモノクローナル抗体酸性細胞株(クローン1H7A10)、抗BRG1モノクローナル抗体酸性細胞株3G4

    2017

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    Grant type:Donation

  • 細胞ポテンシャル測定システムの開発

    2016.10 - 2021.3

    科学技術振興機構JST(日本) 

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    Authorship:Principal investigator 

  • 細胞ポテンシャル測定システムの開発

    2016 - 2021

    戦略的創造研究推進事業 (文部科学省)

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    Authorship:Principal investigator  Grant type:Contract research

  • エピゲノム研究助成

    2016

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    Grant type:Donation

  • エピゲノム研究助成

    2015

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    Grant type:Donation

  • 骨格筋分化における遺伝子発現秩序形成の解明

    2014.4 - 2017.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • 骨格筋分化における遺伝子発現秩序形成の解明

    Grant number:26290064  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • エピゲノム研究助成

    2014

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    Grant type:Donation

  • 細胞分化にともなうクロマチン変動メカニズムの解明

    2013.4 - 2018.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • RNAポリメラーゼⅡ非リン酸化CTDコードの網羅的解読

    2013.4 - 2014.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • 性差を構築するクロマチン構造基盤の解明

    2013.4 - 2014.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • 細胞分化にともなうクロマチン変動メカニズムの解明

    Grant number:25116010  2013 - 2018

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • RNAポリメラーゼII 非リン酸化CTDコードの網羅的解読

    Grant number:25118518  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 性差を構築するクロマチン構造基盤の解明

    Grant number:25132709  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 次世代シークエンサーによる高次エピゲノム解析

    2012.4 - 2016.3

    JST(日本) 

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    Authorship:Coinvestigator(s) 

  • 革新的モノクローナル抗体作製法への挑戦

    2012 - 2013

    九州大学教育研究プログラム・研究拠点形成プロジェクト(P&P)

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • エピゲノム研究助成

    2012

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    Grant type:Donation

  • 高精度遺伝子座同定法の開発

    2011.1 - 2013.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • 分化遺伝子選択における時空間制御機構の解明

    2011.1 - 2012.3

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • 次世代シークエンサーによる高次エピゲノム解析

    2011 - 2016

    戦略的創造研究推進事業 (文部科学省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 骨格筋分化の運命を決定する高次クロマチン構造制御機構の解析

    Grant number:23310134  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 高精度遺伝子座同定法の開発

    Grant number:23651195  2011 - 2012

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 大規模シークエンサーによる多能性幹細胞のエピジェネティックネットワークの解明

    2011

    九州大学 教育研究プログラム P&P D-3タイプ

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 骨格筋分化の運命を決定する高次クロマチン構造制御機構の解析

    2010.1 - 2012.1

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

  • ジーンクラスタリングによる骨格筋分化制御機構の解明

    2009.1 - 2010.1

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

    骨格筋分化をモデル系として、細胞分化の一定時期に、遺伝子座が核内で集積するジーンクラスタリング現象を見出してきた。この形成にかかわる因子を生化学的手法を用いて探索したところ、いくつかのクロマチンリモデリング因子関連因子を同定した。特に、Brg1クロマチンリモデリング因子の活性化を抑止した細胞では遺伝子近接現象が消失し、且つ骨格筋分化も抑制された。そこで、Brg1を起点とするジーンクラスタリング現象について更に解析を進めることとした。その結果、Brg1の活性化を抑制した場合、(1)分化初期に認められるジーンクラスタリングがおこらない(2)その後RNA factoryの形成も阻害される、ことが明らかとなった。これは転写においてジーンクラスタリングが、転写そのものを制御しているわけではなく、転写開始以前になんらかの高次制御を行っていることを示唆している。そこで更に、我々はギガシークエンサーを応用した新たなアプローチを樹立し、バイアスなしにゲノムワイドなジーンクラスタリング現象の把握が可能となった。その結果、骨格筋分化段階特異的な遺伝子座近接部位がゲノム上に存在すること、その多くが遺伝子のプロモーターもしくは他の制御領域に位置していることが明らかとなった。また、逆に細胞を問わず、常に他の遺伝子と近接している領域が存在しておりこれら領域がさまざまな遺伝子群の発現制御に関わっていることが示唆された。また興味深いことに現在アノテーション情報が付与されていない一方で、他の動物種であるヒト、ラットで保存性が高い領域が多く同定された。また、可視化による検討としてDNA-FISHにより遺伝子座近接の検証を行った。予備実験の結果近接が3Cによって確認された筋クレアチンキナーゼ遺伝子座と筋アクチン1の遺伝子座の近接について評価した。その結果、骨格筋細胞のみ、両遺伝子座の近接が2-4%の割合で確認できたのに対し、非筋系ではゼロであった。以上のことから、遺伝子座近接現象がクロマチン構造変換と密接に関わりながら骨格筋分化における転写制御を、極めて初期の段階より制御していることが示唆された。

  • CHD2クロマチンリモデリング因子変異による無秩序遺伝子発現

    2008.1 - 2009.1

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

    ATP依存的クロマチンリモデリング因子SWI/SNF familyは、ATP依存的にクロマチン構造を変換することによって遺伝子の転写を制御している。現在までに、骨格筋分化において、クロマチン構造変換よりも前段階で骨格筋分化に関わる遺伝子群が統合的に制御されるメカニズムがあることが示されている。Chd2は、SWI/SNF familyのひとつと予測されているが、その機能はまだ明らかとなっていない。我々は、Chd2遺伝子変異マウスを作製し、このマウスが個々の組織において秩序だった遺伝子発現パターンが消失し高頻度に発がんすることを見出した。そこで、chd2遺伝子が骨格筋分化における高次遺伝子制御に関わっているかについて検討した。新たに作出したChd2mAbを用いたクロマチン免疫沈降法によって、Chd2は骨格筋の分化マーカー遺伝子のプロモーター領域に遺伝子発現よりも前の段階でリクルートされていた。さらに、CHD2の機能阻害を行ったところ、骨格筋への分化が抑制された。そこで、更にChd2の分子機能を解明するために、抗体アフィニティクロマトグラフィーにより、Chd2複合体の精製を行った。その結果Chd2はヒストンバリアントH3.3及び筋特異的転写因子群と選択的に複合体を形成することが明らかとなった。ゲノムワイドにH3.3筋が取り込まれている領域を探索したところH3.3はプロモーターやエンハンサー等の制御領域にはChd2の活性依存的に取り込まれるのに対し、他のゲノム領域への取り込みには関与していなかった。これらChd2を介する選択的なH3.3特異的の取り込みは他のクロマチン制御と比しても極めて早い段階で行われており、その破綻ががん化に関わっていることからも今後も詳細な分子メカニズムについて引き続き解析が求められる。

  • 細胞分化における高次遺伝子発現制御機構ネットワークの解明

    Grant number:20016020  2008 - 2009

    科学研究費助成事業  特定領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • CHD2クロマチンリモデリング因子に変異による無秩序遺伝子発現機構の解明

    Grant number:20012041  2008 - 2009

    科学研究費助成事業  特定領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 細胞分化における高次遺伝子発現制御機構ネットワークの解明

    2007.1 - 2008.1

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

    本研究プロジェクトでは筋分化において、これらの各イベントが複数のグループ遺伝子ごとにまとまって同調的に制御されていることを見出してきた。これらの骨格筋特異的な遺伝子はゲノム上にランダムに位置していた。このことは、これらの遺伝子群を時期特異的に一括して発現調節する高次のクロマチン構造制御システムが細胞内に存在する事を示唆する。我々はギガシークエンサーを応用した新たなアプローチを樹立し、バイアスなしにゲノムワイドなジーンクラスタリング現象の把握が可能となった。まず、両端がユニークにマウスゲノム上にマッピングされたものを解析対象としたところ、全読み取りタグ1500万に対し、700-800万のタグが該当した。これを遺伝子座近接情報として、解析を進めることとした。骨格筋分化サンプルとして、C2C12細胞を分化刺激し経時的に回収したものと、コントロールとしてNIH3T3を非筋肉細胞として用いた。その結果、骨格筋分化段階特異的な遺伝子座近接部位がゲノム上に存在すること、その多くが遺伝子のプロモーターもしくは他の制御領域に位置していることが明らかとなった。また、逆に細胞を問わず、常に他の遺伝子と近接している領域が存在しておりこれら領域がさまざまな遺伝子群の発現制御に関わっていることが示唆された。また興味深いことに現在アノテーション情報が付与されていない一方で、他の動物種であるヒト、ラットで保存性が高い領域が多く同定された。また、可視化による検討としてDNA-FISH により遺伝子座近接の検証を行った。予備実験の結果近接が3Cによって確認された筋クレアチンキナーゼ遺伝子座と筋アクチン1の遺伝子座の近接について評価した。その結果、骨格筋細胞のみ、両遺伝子座の近接が2-4%の割合で確認できたのに対し、非筋系ではゼロであった。次にこの形成にかかわる因子を探索したところ、Brg1クロマチンリモデリング因子の活性化を抑止した細胞では遺伝子近接現象が消失し、且つ骨格筋分化も抑制された。以上のことから、遺伝子座近接現象がクロマチン構造変換と密接に関わりながら骨格筋分化を制御していることが示唆された。

  • ジーンクラスタリング(遺伝子集積)による骨格筋分化制御機構の解明

    2007.1 - 2008.1

    日本学術振興会(日本) 

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    Authorship:Principal investigator 

    骨格筋分化における遺伝子発現高次制御機構として、遺伝子集積現象について解析を行った。そのために、必要となるゲノムワイドでの遺伝子集積現象の解析系を新たに立ち上げ、その結果、骨格筋分化の極めて初期に染色体の特異的部位が、遺伝子集積を起こすことが明らかとなった。さらに、遺伝子集積を起こす因子群を複数同定し、その機能阻害により骨格筋分化が抑制されたことから遺伝子集積現象が、骨格筋分化の高次制御機構であることが示唆された。

  • ジーンクラスタリング(遺伝子集積)による骨格筋分化制御機構の解明

    2007 - 2008

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 成体幹細胞におけるクロマチンリモデリング機構制御の研究

    2006 - 2011

    科学技術振興調整費 (文部科学省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

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Class subject

  • 生命医科学特論Ⅲ

    2024.6 - 2024.8   Summer quarter

  • 生命医科学Ⅱ

    2024.4 - 2024.6   Spring quarter

  • 生体情報機能学Ⅰ

    2023.10 - 2024.3   Second semester

  • 生命医科学研究入門

    2023.10 - 2024.3   Second semester

  • 生命医科学特論Ⅲ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学Ⅱ

    2023.4 - 2023.6   Spring quarter

  • 生命医科学研究入門

    2022.10 - 2023.3   Second semester

  • 生命医科学特論I

    2022.6 - 2022.8   Summer quarter

  • 生命医科学Ⅱ

    2022.4 - 2022.6   Spring quarter

  • 生命医科学研究入門

    2021.10 - 2022.3   Second semester

  • 生命科学特論Ⅰ

    2021.6 - 2021.8   Summer quarter

  • 生命医科学Ⅱ

    2021.4 - 2021.6   Spring quarter

  • 生命医科学研究入門

    2020.10 - 2021.3   Second semester

  • 生命医科学Ⅱ

    2020.10 - 2020.12   Fall quarter

  • 生命医科学特論

    2020.6 - 2020.8   Summer quarter

  • 生命医科学研究入門

    2019.10 - 2020.3   Second semester

  • 生命医科学 Ⅱ

    2019.10 - 2019.12   Fall quarter

  • 最新トピックスから学ぶ生命科学入門Ⅲ

    2019.10 - 2019.12   Fall quarter

  • 生命医科学特論Ⅰ

    2019.4 - 2019.6   Spring quarter

  • 生命医科学研究入門

    2018.10 - 2019.3   Second semester

  • 生命医科学 Ⅱ

    2018.10 - 2018.12   Fall quarter

  • 最新トピックスから学ぶ生命科学入門Ⅲ

    2018.10 - 2018.12   Fall quarter

  • 生命医科学 特論Ⅰ

    2018.4 - 2018.6   Spring quarter

  • 最新トピックスから学ぶ生命科学入門Ⅳ

    2017.12 - 2018.2   Winter quarter

  • 生命医科学研究入門

    2017.10 - 2018.3   Second semester

  • 生命医科学 Ⅱ

    2017.10 - 2017.12   Fall quarter

  • 生命医科学 特論Ⅰ

    2017.4 - 2017.6   Spring quarter

  • 最新トピックスから学ぶ生命科学入門 II

    2016.10 - 2017.3   Second semester

  • 生命医科学研究入門

    2016.10 - 2017.3   Second semester

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FD Participation

  • 2024.4   Role:Participation   Title:生体防御医学研究所FD(法務コンプライアンス関連FD)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role:Participation   Title:令和4年度馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.1   Role:Participation   Title:カリキュラムを補完する準正課活動の設計に関するFD

    Organizer:University-wide

  • 2018.9   Role:Participation   Title:馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2017.10   Role:Participation   Title:馬出地区キャンパスFD

    Organizer:University-wide

  • 2016.10   Role:Participation   Title:馬出地区キャンパスFD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.2   Role:Participation   Title:Web学習システム(学習管理システム)を利用した教育実践

    Organizer:University-wide

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2023  東京大学  Classification:Intensive course  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:3・4限 13:00~14:45、14:55~16:40

  • 2023  東京大学  Classification:Intensive course  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2023年11月17日(金曜日)14:55~16:40

  • 2023  京都大学  Classification:Intensive course  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2024年2月2日(金曜日)15:00~16:30

  • 2022  東京大学 医学共通講義I 分子細胞生物学入門  Classification:Affiliate faculty  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2022年6月14日(火曜日)10:25-12:10

  • 2022  大阪大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  徳島大学  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2019  広島大学大学院医系科学研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2019年10月30日(火曜日)18:00

  • 2019  東京大学薬学系研究科大学院  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2019年11月15日(金曜日)4限 14:55−16:40

  • 2017  明星大学理工学部 化学専攻 生化学特論B 特別講義  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2017年10月2日

  • 2017  京都大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2017年12月21日

  • 2016  徳島大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2016年6月29日

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Social Activities

  • システム生命科学夏の学校

    九州大学 システム生命科学府  九州大学 システム生命科学府講義棟  2017.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

  • 生命を形作る道の暗号を解読する

    新学術領域「遺伝情報場」、「クロマチン動構造」主催  大阪 千里ライフサイエンスセンター  2013.8

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

Media Coverage

  • 細胞1個でがん診断に応用へ Newspaper, magazine

    日経産業新聞 2020年9月15日  2020.9

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    細胞1個でがん診断に応用へ

  • 遺伝子変化が起きた場所 細胞1個で高精度測定 九大など Newspaper, magazine

    日本経済新聞 2019年3月11日  2019.3

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    遺伝子変化が起きた場所 細胞1個で高精度測定 九大など

  • エピゲノム情報単一細胞で取得 遺伝子発現制御解析に成功 Newspaper, magazine

    科学新聞 2018年12月21日  2018.12

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    エピゲノム情報単一細胞で取得
    遺伝子発現制御解析に成功

  • 筋肉再生を促進するヒストンタンパク質 Newspaper, magazine

    科学新聞 4月27日 第3667号  2018.4

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    筋肉再生を促進するヒストンタンパク質

  • 九大など、DNA/ゲノム編集に利用できる人工たんぱく質を開発可能に

    マイナビニュース  2013.4

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    九大など、DNA/ゲノム編集に利用できる人工たんぱく質を開発可能に

  • 九州大学、細胞が筋肉となるメカニズムを解明

    日経バイオテク アカデミック版  2012.5

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    九州大学、細胞が筋肉となるメカニズムを解明

  • 細胞はいかに筋肉を作るか Newspaper, magazine

    科学新聞  2012.5

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    細胞はいかに筋肉を作るか

  • 細胞はいかにして筋肉をつくるのか?

    Yahoo ニュース  2012.5

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    細胞はいかにして筋肉をつくるのか?

  • 細胞は筋肉組織をどうやって形成しているのか―九大がメカニズムを解明

    マイナビ  2012.5

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    細胞は筋肉組織をどうやって形成しているのか―九大がメカニズムを解明

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Travel Abroad

  • 2023.6

    Staying countory name 1:United Kingdom   Staying institution name 1:Cancer Research UK Cambridge Institute University

  • 2023.2 - 2023.3

    Staying countory name 1:United States   Staying institution name 1:Colorado State University

  • 2023.1

    Staying countory name 1:United States   Staying institution name 1:Colorado State University

  • 2022.8

    Staying countory name 1:United Kingdom   Staying institution name 1:Leicester Institute for Structural and Chemical Biology

  • 2019.9

    Staying countory name 1:United Kingdom   Staying institution name 1:University of Cambridge (Cavendish Laboratory)

  • 2019.9

    Staying countory name 1:Spain   Staying institution name 1:Pompeu Fabra University

  • 2019.9

    Staying countory name 1:Germany   Staying institution name 1:Pompeu Fabra

  • 2019.2

    Staying countory name 1:Singapore   Staying institution name 1:A* STAR Genome Institute of Singapore

  • 2018.9

    Staying countory name 1:Italy   Staying institution name 1:Hilton Metropole Florence

  • 2018.7

    Staying countory name 1:United States   Staying institution name 1:Grand Summit Hotel | Sunday River

  • 2018.4

    Staying countory name 1:United Kingdom   Staying institution name 1:University of Cambridge (Cavendish Laboratory)

  • 2018.4

    Staying countory name 1:Germany   Staying institution name 1:Max Delbrück Center for Molecular Medicine

  • 2017.9

    Staying countory name 1:Germany   Staying institution name 1:BioMedical Center (BMC)

  • 2017.6

    Staying countory name 1:Italy   Staying institution name 1:Renaissance Tuscany Il Ciocco

  • 2017.5

    Staying countory name 1:Sweden   Staying institution name 1:Clarion Hotel Sign, Stockholm

  • 2017.3

    Staying countory name 1:United States   Staying institution name 1:Unviersity of Massachusetts

  • 2017.1

    Staying countory name 1:United States   Staying institution name 1:Resort at Squaw Creek

  • 2016.3

    Staying countory name 1:Canada   Staying institution name 1:Whistler Conference Centre

  • 2015.3 - 2015.4

    Staying countory name 1:United States   Staying institution name 1:Keystone Resort

  • 2015.3 - 2015.4

    Staying countory name 1:United States   Staying institution name 1:Sheraton Steamboat Resort

  • 2014.2

    Staying countory name 1:United States   Staying institution name 1:Santa Fe Community Convention Center

  • 2011.9 - 2011.10

    Staying countory name 1:United States   Staying institution name 1:Unviersity of Massachusetts

  • 2003.5 - 2007.11

    Staying countory name 1:United States   Staying institution name 1:University of Massachusetts Medical School

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