Tissue-specific expression of histone H3 variants diversified after species separation Reviewed

Kazumitsu Maehara, Akihito Harada, Yuko Sato, Masaki Matsumoto, Keiichi Nakayama, Hiroshi Kimura, Yasuyuki Ohkawa

Epigenetics and Chromatin   8 ( 1 )   2015.9

Spatial re-organization of myogenic regulatory sequences temporally controls gene expression Reviewed

Akihito Harada, Chandrashekara Mallappa, Seiji Okada, John T. Butler, Stephen P. Baker, Jeanne B. Lawrence, Yasuyuki Ohkawa, Anthony N. Imbalzano

Nucleic Acids Research   43 ( 4 )   2008 - 2021   2015.2

Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle Reviewed

Akihito Harada, Kazumitsu Maehara, Yuko Sato, Daijiro Konno, Taro Tachibana, Hiroshi Kimura, Yasuyuki Ohkawa

Nucleic Acids Research   43 ( 2 )   775 - 786   2015.1

Chd2 interacts with H3.3 to determine myogenic cell fate Reviewed

Akihito Harada, Seiji Okada, Daijiro Konno, Jun Odawara, Tomohiko Yoshimi, Saori Yoshimura, Hiromi Kumamaru, Hirokazu Saiwai, Toshiaki Tsubota, Hitoshi Kurumizaka, Koichi Akashi, Taro Tachibana, Anthony N. Imbalzano, Yasuyuki Ohkawa

EMBO Journal   31 ( 13 )   2994 - 3007   2012.7

Production of a Monoclonal Antibody for Histone H2b Isoform H2b3b. International journal

Saki Egashira, Taro Tachibana, Mako Nakamura, Yasuyuki Ohkawa, Akihito Harada

Monoclonal antibodies in immunodiagnosis and immunotherapy   43 ( 2 )   75 - 80   2024.4

Monoclonal Antibody Rat 2F11 and Rabbit A3 Against Anti-H2b3b. International journal

Saki Egashira, Taro Tachibana, Mako Nakamura, Yasuyuki Ohkawa, Akihito Harada

Monoclonal antibodies in immunodiagnosis and immunotherapy   43 ( 2 )   81 - 82   2024.4

Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input. International journal

Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura

Nature protocols   2023.11

Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state

Kosuke Tomimatsu, Takeru Fujii, Ryoma Bise, Kazufumi Hosoda, Yosuke Taniguchi, Hiroshi Ochiai, Hiroaki Ohishi, Kanta Ando, Ryoma Minami, Tachibana Taro, Kaori Tanaka, Seiichi Mori, Akihito Harada, Kazumitsu Maehara, Masao Nagasaki, Seiichi Uchida, Hiroshi Kimura, Masashi Narita, Yasuyuki Ohkawa

2023.10

FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation Reviewed International journal

Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama

Cell Reports   42 ( 5 )   112530 - 112530   2023.5

Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections. Reviewed International journal

Mizuki Honda, Ryuichi Kimura, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Yasuyuki Ohkawa, Shinya Oki

STAR protocols   3 ( 2 )   101346 - 101346   2022.6

High-depth spatial transcriptome analysis by photo-isolation chemistry Reviewed International journal

Mizuki Honda, Shinya Oki, Ryuichi Kimura, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Chikara Meno, Yasuyuki Ohkawa

Nature Communications   12 ( 1 )   2021.12

Recent advances in single-cell epigenomics. Reviewed International journal

Akihito Harada, Hiroshi Kimura, Yasuyuki Ohkawa

Current opinion in structural biology   71   116 - 122   2021.12

Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay. Reviewed International journal

Hiroaki Tachiwana, Mariko Dacher, Kazumitsu Maehara, Akihito Harada, Yosuke Seto, Ryohei Katayama, Yasuyuki Ohkawa, Hiroshi Kimura, Hitoshi Kurumizaka, Noriko Saitoh

eLife   10   2021.5

Transcriptome analysis of gene expression changes upon enzymatic dissociation in skeletal myoblasts. Reviewed International journal

Atsuko Miyawaki-Kuwakado, Qianmei Wu, Akihito Harada, Kosuke Tomimatsu, Takeru Fujii, Kazumitsu Maehara, Yasuyuki Ohkawa

Genes to cells : devoted to molecular & cellular mechanisms   2021.5

Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound

Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui

Journal of Allergy and Clinical Immunology   2021.4

Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound Reviewed International journal

Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui.

The Journal of Allergy and Clinical Immunology   2021.4

Genome-wide analysis of chromatin structure changes upon MyoD binding in proliferative myoblasts during the cell cycle. Reviewed International journal

Qianmei Wu, Takeru Fujii, Akihito Harada, Kosuke Tomimatsu, Atsuko Miyawaki-Kuwakado, Masatoshi Fujita, Kazumitsu Maehara, Yasuyuki Ohkawa

Journal of biochemistry   2021.1

Modeling population size independent tissue epigenomes by ChIL-seq with single-thin sections Reviewed International journal

Kazumitsu Maehara, Kosuke Tomimatsu, Akihito Harada, Kaori Tanaka, Shoko Sato, Seiji Okada, Tetsuya Handa, Hitoshi Kurumizaka, Hiroshi Kimura, Yasuyuki Ohkawa

Molecular Systems Biology   2020.12

Subnuclear gene positioning through lamina association affects copper tolerance Reviewed International journal

Yuki Sakamoto, Mayuko Sato, Yoshikatsu Sato, Akihito Harada, Takamasa Suzuki, Chieko Goto, Kentaro Tamura, Kiminori Toyooka, Hiroshi Kimura, Yasuyuki Ohkawa, Ikuko Hara-Nishimura, Shingo Takagi, Sachihiro Matsunaga

Nature Communications   11 ( 1 )   2020.12

Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input. Reviewed International journal

Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura

Nature protocols   15 ( 10 )   3334 - 3360   2020.10

Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells. Reviewed International journal

Hiroshi Ochiai, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Akihito Harada, Yukiko Shimizu, Kenta Nakano, Noriko Saitoh, Zhe Liu, Takashi Yamamoto, Tadashi Okamura, Yasuyuki Ohkawa, Hiroshi Kimura, Itoshi Nikaido

Science advances   6 ( 25 )   eaaz6699   2020.6

Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells Reviewed

Masahiro Oka, Sonoko Mura, Mayumi Otani, Yoichi Miyamoto, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Taro Tachibana, Yoshihiro Yoneda, Yasuyuki Ohkawa

eLife   8   2019.11

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle Reviewed

Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, Yu Taro Noguchi, Yusei Takemoto, Lidan Zhang, Kazutake Tsujikawa, Hiroki Kokubo, Akiyoshi Uezumi, Kazumitsu Maehara, Akihito Harada, Yasuyuki Ohkawa, So Ichiro Fukada

eLife   8   2019.9

Biochemical analysis of nucleosome targeting by Tn5 transposase Reviewed

Shoko Sato, Yasuhiro Arimura, Tomoya Kujirai, Akihito Harada, Kazumitsu Maehara, Jumpei Nogami, Yasuyuki Ohkawa, Hitoshi Kurumizaka

Open Biology   9 ( 8 )   2019.8

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells HeyL requires HeS1 to bind diverse DNA sites Reviewed

Yu Taro Noguchi, Miki Nakamura, Nobumasa Hino, Jumpei Nogami, Sayaka Tsuji, Takahiko Sato, Lidan Zhang, Kazutake Tsujikawa, Toru Tanaka, Kohei Izawa, Yoshiaki Okada, Takefumi Doi, Hiroki Kokubo, Akihito Harada, Akiyoshi Uezumi, Manfred Gessler, Yasuyuki Ohkawa, So Ichiro Fukada

Development (Cambridge)   146 ( 4 )   2019.2

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection Reviewed

Kazu Kobayakawa, Kyleigh Alexis DePetro, Hui Zhong, Bau Pham, Masamitsu Hara, Akihito Harada, Jumpei Nogami, Yasuyuki Ohkawa, V. Reggie Edgerton

Neurorehabilitation and Neural Repair   2019.1

Roles of histone H3.5 in human spermatogenesis and spermatogenic disorders Reviewed

K. Shiraishi, A. Shindo, Akihito Harada, H. Kurumizaka, H. Kimura, Yasuyuki Ohkawa, H. Matsuyama

Andrology   6 ( 1 )   158 - 165   2018.1

Sensitive detection of fluorescence in western blotting by merging images Reviewed

Yukari Kondo, Shinichiro Higa, Takeshi Iwasaki, Tomoya Matsumoto, Kazumitsu Maehara, Akihito Harada, Yoshihiro Baba, Masatoshi Fujita, Yasuyuki Ohkawa

PLoS One   13 ( 1 )   2018.1

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells Reviewed

Yuichiro Semba, Akihito Harada, Kazumitsu Maehara, Shinya Oki, Chikara Meno, Jun Ueda, Kazuo Yamagata, Atsushi Suzuki, Mitsuho Onimaru, Jumpei Nogami, Seiji Okada, Koichi Akashi, Yasuyuki Ohkawa

Nucleic Acids Research   45 ( 15 )   8758 - 8772   2017.9

Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Reviewed

Hiroyuki Taguchi, Yan Xie, Naoki Horikoshi, Kazumitsu Maehara, Akihito Harada, Jumpei Nogami, Koichi Sato, Yasuhiro Arimura, Akihisa Osakabe, Tomoya Kujirai, Takeshi Iwasaki, Yuichiro Semba, Taro Tachibana, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka

Biochemistry   56 ( 16 )   2184 - 2196   2017.4

ROLES OF HISTONE H3.5 IN HUMAN SPERMATOGENESIS AND SPERMATOGENIC DISORDERS Reviewed

Koji Shiraishi, Aya Shindo, Akihito Harada, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Hiroshi Kimura, Hideyasu Matsuyama

JOURNAL OF UROLOGY   197 ( 4 )   E85 - E85   2017.4

Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury Reviewed

Kazuya Yokota, Kazu Kobayakawa, Takeyuki Saito, Masamitsu Hara, Ken Kijima, Yasuyuki Ohkawa, Akihito Harada, Ken Okazaki, Kohei Ishihara, Shigeo Yoshida, Akira Kudo, Yukihide Iwamoto, Seiji Okada

American Journal of Pathology   187 ( 3 )   639 - 653   2017.3

The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation Reviewed

Kensuke Kudou, Tetsuro Komatsu, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Yasuyuki Ohkawa

Open Biology   7 ( 9 )   2017.1

Identification of immunoglobulin gene sequences from a small read number of mRNA-seq using hybridomas Reviewed

Yuki Kuniyoshi, Kazumitsu Maehara, Takeshi Iwasaki, Masayasu Hayashi, Yuichiro Semba, Masatoshi Fujita, Yuko Sato, Hiroshi Kimura, Akihito Harada, Yasuyuki Ohkawa

PLoS One   11 ( 10 )   2016.10

Histone H4 lysine 20 acetylation is associated with gene repression in human cells Reviewed

Jun Ya Kaimori, Kazumitsu Maehara, Yoko Hayashi-Takanaka, Akihito Harada, Masafumi Fukuda, Satoko Yamamoto, Naotsugu Ichimaru, Takashi Umehara, Shigeyuki Yokoyama, Ryo Matsuda, Tsuyoshi Ikura, Koji Nagao, Chikashi Obuse, Naohito Nozaki, Shiro Takahara, Toshifumi Takao, Yasuyuki Ohkawa, Hiroshi Kimura, Yoshitaka Isaka

Scientific Reports   6   2016.4

Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2 Reviewed

Masayasu Hayashi, Kazumitsu Maehara, Akihito Harada, Yuichiro Semba, Kensuke Kudo, Hidehisa Takahashi, Shinya Oki, Chikara Meno, Kenji Ichiyanagi, Koichi Akashi, Yasuyuki Ohkawa

Journal of Cellular Biochemistry   117 ( 3 )   780 - 792   2016.3

Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis Reviewed

Takashi Urahama, Akihito Harada, Kazumitsu Maehara, Naoki Horikoshi, Koichi Sato, Yuko Sato, Koji Shiraishi, Norihiro Sugino, Akihisa Osakabe, Hiroaki Tachiwana, Wataru Kagawa, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka

Epigenetics and Chromatin   9 ( 1 )   2016.1

Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies Reviewed

Yoko Hayashi-Takanaka, Kazumitsu Maehara, Akihito Harada, Takashi Umehara, Shigeyuki Yokoyama, Chikashi Obuse, Yasuyuki Ohkawa, Naohito Nozaki, Hiroshi Kimura

Chromosome Research   23 ( 4 )   753 - 766   2015.12

Relationship between the risk for a shrimp allergy and freshness or cooking Reviewed

Masakatsu Usui, Akihito Harada, Shinya Yasumoto, Yoshimasa Sugiura, Anri Nishidai, Maria Ikarashi, Honami Takaba, Taiko Miyasaki, Hiroyuki Azakami, Masakazu Kondo

Bioscience, Biotechnology and Biochemistry   79 ( 10 )   1698 - 1701   2015.1

Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2 Reviewed

Masako Tanaka, Maki Yamaguchi, Masayuki Shiota, Yukiko Kawamoto, Katsuyuki Takahashi, Azusa Inagaki, Mayuko Osada-Oka, Akihito Harada, Hideki Wanibuchi, Yasukatsu Izumi, Katsuyuki Miura, Hiroshi Iwao, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   33 ( 4 )   261 - 269   2014.8

Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions Reviewed

Masako Tanaka, Saya Mun, Akihito Harada, Yasuyuki Ohkawa, Azusa Inagaki, Soichi Sano, Katsuyuki Takahashi, Yasukatsu Izumi, Mayuko Osada-Oka, Hideki Wanibuchi, Masayo Yamagata, Tokihito Yukimura, Katsuyuki Miura, Masayuki Shiota, Hiroshi Iwao

PLoS One   9 ( 5 )   2014.5

Generation of a monoclonal antibody for INI1/hSNF5/BAF47 Reviewed

Akihito Harada, Masayasu Hayashi, Yuuki Kuniyoshi, Yuichiro Semba, Satoko Sugahara, Taro Tachibana, Yasuyuki Ohkawa, Masatoshi Fujita

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   33 ( 1 )   49 - 51   2014.2

Production of a monoclonal antibody for C/EBPβ The subnuclear localization of C/EBPβ in mouse L929 cells Reviewed

33 ( 1 )   34 - 37   2014.2

Contribution of structural reversibility to the heat stability of the tropomyosin shrimp allergen Reviewed

Masakatsu Usui, Akihito Harada, Takayuki Ishimaru, Emiri Sakumichi, Fumihiko Saratani, Chiho Sato-Minami, Hiroyuki Azakami, Taiko Miyasaki, Ken'ichi Hanaoka

Bioscience, Biotechnology and Biochemistry   77 ( 5 )   948 - 953   2013.6

A co-localization model of paired ChIP-seq data using a large ENCODE data set enables comparison of multiple samples Reviewed

Kazumitsu Maehara, Jun Odawara, Akihito Harada, Tomohiko Yoshimi, Koji Nagao, Chikashi Obuse, Koichi Akashi, Taro Tachibana, Toshio Sakata, Yasuyuki Ohkawa

Nucleic Acids Research   41 ( 1 )   54 - 62   2013.1

Structural reversibility contributes the heat stability of shrimp allergen tropomyosin Reviewed

M. Usui, A. Harada, T. Ishimaru, E. Sakumichi, F. Saratani, C. Sato, H. Azakami, T. Miyasaki, K. Hanaoka

Bioscience, Biotechnology, and Biochemistry   77 ( 5 )   2012.5

The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach Reviewed

Jun Odawara, Akihito Harada, Tomohiko Yoshimi, Kazumitsu Maehara, Taro Tachibana, Seiji Okada, Koichi Akashi, Yasuyuki Ohkawa

BMC Genomics   12   2011.10

Generation of a rat monoclonal antibody specific for Hsp72 Reviewed

Masako Tanaka, Masayuki Shiota, Seiji Okada, Akihito Harada, Jun Odawara, Saya Mun, Hiroshi Iwao, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   30 ( 4 )   397 - 400   2011.8

Flow cytometric sorting of neuronal and glial nuclei from central nervous system tissue Reviewed

Seiji Okada, Hirokazu Saiwai, Hiromi Kumamaru, Kensuke Kubota, Akihito Harada, Masahiro Yamaguchi, Yukihide Iwamoto, Yasuyuki Ohkawa

Journal of Cellular Physiology   226 ( 2 )   552 - 558   2011.2

Generation of a rat monoclonal antibody specific for heat shock cognate protein 70 Reviewed

Masayuki Shiota, Hirokazu Saiwai, Saya Mun, Akihito Harada, Seiji Okada, Jun Odawara, Masako Tanaka, Hiroshi Iwao, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 5 )   453 - 456   2010.10

Monoclonal antibody specific for Dhx9/NDHII/RHA Reviewed

Manato Kotani, Akihito Harada, Jun Odawara, Masayuki Azuma, Seiji Okada, Yuko Nishiyama, Mako Nakamura, Taro Tachibana, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   259 - 261   2010.6

Rat monoclonal antibody specific for MyoD Reviewed

Akihito Harada, Yasuyuki Ohkawa, Shinpei Ao, Jun Odawara, Seiji Okada, Masayuki Azuma, Yuko Nishiyama, Mako Nakamura, Taro Tachibana

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   255 - 258   2010.6

Rat monoclonal antibody specific for the chromatin remodeling factor, CHD1 Reviewed

Saori Yoshimura, Akihito Harada, Jun Odawara, Masayuki Azuma, Seiji Okada, Mako Nakamura, Yasuyuki Ohkawa, Taro Tachibana

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 3 )   237 - 240   2010.6

Generation of a rat monoclonal antibody specific for Chd2 Reviewed

Akihito Harada, Saori Yoshimura, Jun Odawara, Masayuki Azuma, Seiji Okada, Mako Nakamura, Taro Tachibana, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 2 )   173 - 177   2010.4

Production of a rat monoclonal antibody specific for Myf5 Reviewed

Akihito Harada, Seiji Okada, Jun Odawara, Hiromi Kumamaru, Hirokazu Saiwai, Mayumi Aoki, Mako Nakamura, Yuko Nishiyama, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   29 ( 1 )   59 - 62   2010.2

The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury Reviewed

Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Hiromi Kumamaru, Akihito Harada, Hideyuki Okano, Takehiko Yokomizo, Yukihide Iwamoto, Seiji Okada

American Journal of Pathology   176 ( 5 )   2352 - 2366   2010.1

Generation of a rat monoclonal antibody specific for Pax7 Reviewed

Akihito Harada, Seiji Okada, Hirokazu Saiwai, Mayumi Aoki, Mako Nakamura, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   28 ( 6 )   451 - 453   2009.12

Production of a rat monoclonal antibody against Brg1 Reviewed

Yasuyuki Ohkawa, Akihito Harada, Mako Nakamura, Saori Yoshimura, Taro Tachibana

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   28 ( 6 )   463 - 466   2009.12

Generation of a rat monoclonal antibody specific for Brm Reviewed

Seiji Okada, Akihito Harada, Hirokazu Saiwai, Mako Nakamura, Yasuyuki Ohkawa

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy   28 ( 6 )   455 - 458   2009.12

Amyloid fibril formation of hen lysozyme depends on the instability of the C-helix (88-99) Reviewed

Akihito Harada, Hiroyuki Azakami, Akio Kato

Bioscience, Biotechnology and Biochemistry   72 ( 6 )   1523 - 1530   2008.7

Relationship between the stability of hen egg-white lysozymes mutated at sites designed to interact with α-helix dipoles and their secretion amounts in yeast Reviewed

71 ( 12 )   2952 - 2961   2007.12

Characterization of recombinant amyloidogenic chicken cystatin mutant I66Q expressed in yeast Reviewed

Jianwei He, Youtao Song, Nobuhiro Ueyama, Akihito Harada, Hiroyuki Azakami, Akio Kato

Journal of Biochemistry   137 ( 4 )   477 - 485   2005.4

Effect of EPS1 gene deletion in Saccharomyces cerevisiae on the secretion of foreign proteins which have disulfide bridges Reviewed

Jianwei He, Takashi Sakamoto, Youtao Song, Akira Saito, Akihito Harada, Hiroyuki Azakami, Akio Kato

FEBS Letters   579 ( 11 )   2277 - 2283   2005.4

細胞状態変化を計測するためのマルチオミクス技術開発 Invited

原田哲仁、富松航佑

第16回日本エピジェネティクス研究会年会  2023.6 

単一細胞エピゲノム解析を用いたクロマチンマッピングによるゲノム機能の解明 Invited

原⽥ 哲仁、藤井 健、前原 ⼀満、⽊村 宏、⼤川 恭⾏

第45回日本分子生物学会  2022.6 

単一細胞エピゲノム解析によるゲノム動作原理の理解

原田 哲仁

第15回日本エピジェネティクス研究会  2022.6 

Epigenomic lineage tracing toward the understanding acquisition of tissue-specific gene expression profile Invited

Akihito Harada

2021.9 

組織特異的な遺伝子発現機構の解明 Invited

原田哲仁

筑波大学TARAセミナー  2022.4 

ChIL法による単一細胞プロファイリング Invited

第45回日本分子生物学会年会  2021.12 

単一細胞解析の最前線 Invited

原田哲仁

山口大学年次セミナー  2020.12 

ChIL法による単一細胞エピゲノムプロファイリング

原田哲仁、前原一満、半田 哲也、木村 宏、大川 恭行

第43回日本分子生物学会  2020.12 

ヒストンH3バリアントの選択的取り込みによる組織特異的な遺伝子発現制御

原田 哲仁, 小松 哲郎, 前原 一満, 近藤 友佳理, 田中 かおり, 桑門 温子, 佐藤 優子, 木村 宏, 林 克彦, 小野 悠介, 竹本 龍也, 胡桃坂 仁志, 大川 恭行

第47回日本分子生物学会年会  2019.12 

単一細胞multi-omicsによりシンギュラリティ一細胞同定技術の開発

原田哲仁

新学術領域研究「シンギュラリティ生物学」第2回領域会議  2019.5 

ChIL法を用いたエピゲノムおよび転写量を同時計測する技術開発

原田哲仁、前原一満、半田哲也、木村宏、大川恭行

新学術領域研究「クロマチン潜在能」第2回班会議  2019.6 

Analysis of genomic structures responsible for tissue-specific gene expression

2019.11 

極微量サンプルからのクロマチン修飾解析を可能にするChIL-seqの紹介 Invited

原田哲仁

トランスオミクス医学研究拠点ネットワーク形成事業 技術講習会  2019.3 

生殖細胞におけるヒストンバリアントによるゲノムマーキング機構の解明

原田　哲仁

新学術領域 生殖細胞のエピゲノムダイナミクスとその制御 取りまとめ公開シンポジウム  2018.12 

非免疫沈降法ChILT法による少数細胞のエピゲノム解析

原田哲仁、半田哲也、野上順平、有村泰宏、関根慧、中尾勝、藤田理沙、前原一満、胡桃坂仁志、木村宏、大川恭行

2017年度生命科学系学会合同年次大会  2017.12 

生殖細胞におけるヒストンバリアントによるゲノムマーキング機構の解明

原田哲仁

生殖細胞のエピゲノムダイナミクスとその制御 第5回公開シンポジウム  2017.11 

急性期の筋萎縮過程における遺伝子発現変動解析

原田 哲仁, 岩崎 健, 横田 和也, 岡田 誠司, 大川 恭行

日本農芸化学会2017年度大会  2017.3 

Functional switching of histone H3 variants in myogenesis Invited

2017.2 

エピジェネティック破綻により引き起こされた筋肉腫の解析 Invited

原田 哲仁

公益財団法人福岡県すこやか健康事業団平成28年度がん研究助成金優秀賞受賞講演  2017.1 

ヒストンH3バリアントの発現変動は筋萎縮過程の初期イベントである

原田 哲仁, 岩崎 健, 横田 和也, 岡田 誠司, 大川 恭行

第39回日本分子生物学会年会  2016.11 

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration. International conference

Harada A

2017.9 

骨格筋分化におけるクロマチン構造解析-トランスクリプトミクスで理解する骨格筋形成 Invited

原田 哲仁

日本農芸化学会中四国支部 支部創立15周年記念 第24回若手シンポジウム  2016.7 

シングルセルでのエピゲノム情報の計測技術

原田 哲仁, 大川 恭行

羊土社 実験医学 2020年 Vol.38   2020.4

クロマチン挿入標識法（ChIL）による単一細胞エピゲノム解析

原田 哲仁,大川 恭行

羊土社 実験医学 2019年増刊号Vol.37   2019.12

発生起源の違いに着目した身体内骨格筋の不均一性と筋再性制御の違い

吉岡 潔志, 瀬古 大暉, 北嶋 康雄, 土屋 吉史, 野上 順平, 原田 哲仁, 大川 恭行, 岡崎 成弘, 米倉 暁彦, 千葉 恒, 大場 誠悟, 住田 吉慶, 朝比奈 泉, 小野 悠介

日本筋学会学術集会プログラム・抄録集   2018.8

Temporal regulation of chromatin during myoblast differentiation.

Harada A, Ohkawa Y, Imbalzano AN

Semin Cell Dev Biol   2017.12

無精子症における精巣内内分泌環境に着目した単一細胞トランスクリプトーム解析

2022.4 - 2025.3

無精子症における精巣内内分泌環境に着目した単一細胞トランスクリプトーム解析

Grant number：22K09475  2022 - 2024

日本学術振興会  科学研究費助成事業  基盤研究(C)

無精子症における精巣内内分泌環境に着目した単一細胞トランスクリプトーム解析

Grant number：22K09475  2022 - 2024

日本学術振興会  科学研究費助成事業  基盤研究(B)

競合的コミュニケーションから迫る多細胞生命システムの自律性

Grant number：21H05283  2021 - 2025

日本学術振興会  科学研究費助成事業  基盤研究(B)

競合的コミュニケーションから迫る多細胞生命システムの自律性

Grant number：21H05283  2021 - 2025

日本学術振興会・文部科学省  科学研究費助成事業  学術変革領域研究(A)

細胞競合における細胞間相互作用を計測するための空間オミクス技術開発

Grant number：21H05292  2021 - 2025

日本学術振興会・文部科学省  科学研究費助成事業  学術変革領域研究(A)

革新的Perturb-ChIL法を用いた網羅的なクロマチン構造解析研究

Grant number：21H00430  2021 - 2022

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

位置情報を保持したシンギュラリティ細胞の遺伝子発現測定技術の開発

Grant number：21H00430  2021

日本学術振興会  科学研究費助成事業  基盤研究(B)

単一細胞解析によるヘルペスウイルス慢性感染の分子基盤の解明

2020 - 2022

国立研究開発法人 日本医療研究開発機構

全能性獲得機構の解明のためのmulti-omics技術の開発

Grant number：20H05368  2020 - 2021

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

組織特異的ゲノム構造の再構築技術の開発

2019 - 2022

戦略的創造研究推進事業 (文部科学省)

単一細胞遺伝子解析によるヒト造精機能障害の分子機構の解明

Grant number：19K09712  2019 - 2021

日本学術振興会  科学研究費助成事業  基盤研究(C)

精子特異的ヒストンバリアントH3T/tを起点としたクロマチンダイナミクスの解明

Grant number：19H03211  2019 - 2021

日本学術振興会  科学研究費助成事業  基盤研究(B)

単一細胞multi-omicsによるシンギュラリティー細胞同定技術の開発

Grant number：19H05425  2019 - 2020

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

単一細胞超高解像度解析を可能にするゲノム3次元構造解析技術の開発

Grant number：18K19432  2018 - 2019

日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

エピジェネティック破綻により引き起こされた筋肉腫の解析

2016 - 2018

公益財団法人福岡県すこやか健康事業団平成28年度がん研究助成金

生殖細胞におけるヒストンバリアントによるゲノムマーキング機構の解明

Grant number：16H01219  2016 - 2017

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

骨格筋分化における新規ヒストンH3バリアントH3mm7の遺伝子選択機構の解明

Grant number：15K18457  2015 - 2016

科学研究費助成事業  若手研究(B)

細胞分化運命決定の遺伝子選択メカニズムの解明

Grant number：13J04024  2013 - 2015

日本学術振興会  科学研究費助成事業  基盤研究(B)

生命医科学特論Ⅰ

2021.6 - 2021.8   Summer quarter

Topics in medical life sciences Ⅰ

2021.6 - 2021.8   Summer quarter

生命医科学特論I

2020.6 - 2020.8   Summer quarter

最新トピックスから学ぶ生命科学入門

2019.10 - 2019.12   Fall quarter

生命医科学特論I

2019.4 - 2019.6   Spring quarter

生命医科学特論I

2018.4 - 2018.6   Spring quarter

2021.7   Role：Participation   Title：生体防御医学研究所FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2021.2   Role：Participation   Title：馬出地区4部局合同男女共同参画ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]

2020.11   Role：Participation   Title：馬出地区4部局合同男女共同参画ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]

2020.9   Role：Participation   Title：M2B学習支援システム講習会（オンライン開催）◇初級編・中級編◇10:00～12:00

Organizer：University-wide

2020.8   Role：Participation   Title：【IDE大学セミナー】大学教職員の多様な働き方について

2019.10   Role：Participation   Title：馬出地区4部局合同男女共同参画ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]

2018.10   Role：Participation   Title：馬出地区4部局合同男女共同参画ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]