UEZUMI MADOKA
Organization
Medical Institute of Bioregulation Medical Research Center for High Depth Omics Assistant Professor
Medical Institute of Bioregulation Medical Research Center for High Depth Omics（Concurrent）
Title
Assistant Professor
Contact information
Tel
0926426881
Profile
生命科学・医学の基礎研究および教育
External link
ORCID
Research Areas
-
Life Science / Nutrition science and health science
Degree
-
PhD in Nutrition （ The University of Tokushima ）
Research History
-
The University of Tokushima
Education
-
The University of Tokushima
Research Interests・Research Keywords
-
Research theme： Elucidation of skeletal muscle aging mechanisms and development of prevention and treatment methods
Keyword： skeletal muscle, aging, sarcopenia, neuromuscular junction, mesenchymal progenitor
Research period： 2023.3
Papers
-
Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging Reviewed
Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Yuki Yoshimoto, Keitaro Minato, Noriyuki Kaji, Takashi Chaen, Eiji Hase, Takeo Minamikawa, Takeshi Yasui, Kazuhide Horiguchi, Satoshi Iino, Masatoshi Hori, Akiyoshi Uezumi
Aging Cell e14299 2024.11
-
Transcriptome analysis of mesenchymal stromal cells of the large and small intestinal smooth muscle layers reveals a unique gastrontestinal stromal signature. Reviewed International journal
Chaen T., Kurosawa T., Kishi K., Kaji N., Ikemoto-Uezumi M., Uezumi A., Hori M.
Biochem Biophys Rep. 2023.4
-
Whole-mount immunofluorescence staining of mesenchymal progenitors in murine plantaris muscle. Reviewed International journal
Kurosawa T, Ikemoto-Uezumi M, Kaneshige A, Fukada S, Uezumi A
STAR Protocols 2022.7
-
Detection of muscle stem cell-derived myonuclei in murine overloaded muscles. Reviewed International journal
Kaneshige A, Kaji T, Saito H, Higashimoto T, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Uezumi A, Fukada S
STAR Protocols 2022.4
-
Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation. Reviewed International journal
Yoshimoto Y, Uezumi A, Ikemoto-Uezumi M, Tanaka K, Yu X, Kurosawa T, Yambe S, Maehara K, Ohkawa Y, Sotomaru Y, Shukunami C
Front Cell Dev Biol 2022.3
-
Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load. Reviewed International journal
Kaneshige A, Kaji T, Zhang L, Saito H, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Tsujikawa K, Seno S, Hori M, Saito Y, Matozaki T, Maehara K, Ohkawa Y, Potente M, Watanabe S, Braun T, Uezumi A, Fukada S
Cell Stem Cell 2022.2
-
Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. Reviewed International journal
Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Toyoda M, Kanazawa N, Nakazawa T, Morita M, Tsuchida K, Uezumi A
Aging Cell 2022.1
-
Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice. Reviewed International journal
Minato K, Yoshimoto Y, Kurosawa T, Watanabe K, Kawashima H, Ikemoto-Uezumi M, Uezumi A
Int J Mol Sci 2021.11
-
Transgenic expression of Bmp3b in mesenchymal progenitors mitigates age-related muscle mass loss and neuromuscular junction degeneration. Reviewed International journal
Kurosawa T, Minato K, Ikemoto-Uezumi M, Hino J, Tsuchida K, Uezumi A
Int J Mol Sci 2021.9
-
Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNFα. Reviewed International journal
Kurosawa T, Goto M, Kaji N, Aikiyo S, Mihara T, Ikemoto-Uezumi M, Toyoda M, Kanazawa N, Nakazawa T, Hori M, Uezumi A
Cell Death Dis 2021.1
-
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia. Reviewed International journal
Uezumi A, Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Nakatani M, Hitachi K, Yamaguchi H, Wakatsuki S, Araki T, Morita M, Yamada H, Toyoda M, Kanazawa N, Nakazawa T, Hino J, Fukada SI, Tsuchida K
J Clin Invest 2021.1
-
Methods for accurate assessment of myofiber maturity during skeletal muscle regeneration. Reviewed International journal
Yoshimoto Y, Ikemoto-Uezumi M, Hitachi K, Fukada SI, Uezumi A
Front Cell Dev Biol 2020.4
-
The CalcR-PKA-Yap1 axis is critical for maintaining quiescence in muscle stem cells. Reviewed International journal
Zhang L, Noguchi Y, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI
Cell Rep 2019.11
-
Tbx1 Regulates Inherited Metabolic and Myogenic Abilities of Progenitor Cells Derived from Slow- and Fast-type Muscle. Reviewed International journal
Motohashi N, Uezumi A, Asakura A, Ikemoto-Uezumi M, Mori S, Mizunoe Y, Takashima R, Miyagoe-Suzuki Y, Takeda S, Shigemoto K
Cell Death Differ 2019.6
-
Reduced expression of calcitonin receptor is closely associated with age-related loss of the muscle stem cell pool. Reviewed International journal
Ikemoto-Uezumi M, Uezumi A, Zhang L, Zhou H, Hashimoto N, Okamura K, Matsui Y, Tsukazaki K, Hosoyama T, Nakatani M, Morita M, Yamada H, Tsuchida K, Fukada SI
JCSM Rapid Commun 2019.4
Books
-
Analyses of Mesenchymal Progenitors in Skeletal Muscle by Fluorescence-Activated Cell Sorting and Tissue Clearing.
Ikemoto-Uezumi M., Kurosawa T., Minato K., Uezumi A.
Methods Mol Biol. 2023.5
Presentations
-
Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. Invited International conference
Madoka Uezumi
1st Symposium on "Skeletal muscle cells in Growth and Disease" 2023.5
-
間葉系前駆細胞の不均一性が支える筋健全性維持メカニズムの解明．
長谷川 優花，上住 円，林 晋一郎，野口 悟，西野 一三，黒澤 珠希，二川 健，上住 聡芳
第9回日本筋学会学術集会 2023.8
-
筋特異的ノックアウトマウスを用いたミトコンドリアアコニターゼの機能解析．
二川 健，岸田 昂大，高田 実穂，榊原 伊織，今井 祐記，上住 円，上住 聡芳
第9回日本筋学会学術集会 2023.8
-
ヒト筋管細胞を用いた筋肥大作用を有する天然由来生理活性物質の同定．
上住 円，黒澤 珠希，布川 朋也，二川 健，上住 聡芳
第9回日本筋学会学術集会 2023.8
-
模擬微小重力下におけるAconitase2の失活と骨格筋特異的Aco2欠損マウスの解析
日本骨代謝学会学術集会 2024.6
-
成体マウス骨格筋におけるアコニターゼ2の機能解明
日本栄養・食糧学会大会 2024.4
-
Inactivation of Aconitase2 under simulated microgravity and analysis of skeletal muscle- specific Aco2-deficient mice
AOMC-JMS 2024 2024.9
-
Elucidation of muscle integrity mechanisms supported by heterogeneity of mesenchymal progenitors.
2025 Symposium on “Skeletal muscle Development, Maintenance, and Adaptation” 2025.3
-
間葉系前駆細胞の不均一性が支える筋健全性維持機構の解明. Invited
第47回⽇本分⼦⽣物学会年会 2024.11
-
Elucidation of muscle integrity mechanisms supported by heterogeneity of mesenchymal progenitors.
AOMC-JMS 2024 2024.9
MISC
-
筋萎縮の背景となる筋生物学の進歩間葉系間質細胞による骨格筋の健全性維持機構とその加齢変容
実験医学 2025.3
-
【骨格筋の再生・維持・適応メカニズムの新知見-最先端研究がもたらしたパラダイムシフト】間葉系 間質細胞による筋維持機構
医学のあゆみ 2024.6
-
最先端医療の今 サルコペニアの治療標的としての間葉系間質細胞
Medical Science Digest 2024.6
-
サルコペニアの発症機序．
上住 円，上住 聡芳
別冊・医学のあゆみ 2023.10
-
骨格筋〜臓器・疾患と線維化（症）〜．
上住 円，上住 聡芳
別冊・実験医学 2023.10
Professional Memberships
-
日本再生医療学会
-
日本筋学会
-
日本分子生物学会
Academic Activities
-
Screening of academic papers
Role(s)： Peer review
2023
Research Projects
-
サルコペニアおよび神経筋疾患の新規治療法開発
2023.3
Authorship：Principal investigator
-
サルコペニアおよび神経筋疾患の新規治療法開発
2022 - 2024
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator Grant type：Scientific research funding
-
筋再生システムの老化を若返らせる分子機構
2019 - 2022
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
Educational Activities
-
生命科学・医学に関する研究指導および教育
Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.
-
2024 徳島大学大学院医科栄養学研究科
-
2023 徳島大学大学院医歯薬学研究部 Classification:Part-time lecturer Domestic/International Classification:Japan