UEZUMI MADOKA
Organization
Medical Institute of Bioregulation Medical Research Center for High Depth Omics Assistant Professor
Medical Institute of Bioregulation Medical Research Center for High Depth Omics（Joint Appointment）
Title
Assistant Professor
Contact information
Tel
0926426881
Profile
生命科学・医学の基礎研究および教育
External link
ORCID
Degree
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PhD in Nutrition
Research History
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The University of Tokushima
Research Interests・Research Keywords
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Research theme：Elucidation of skeletal muscle aging mechanisms and development of prevention and treatment methods
Keyword：skeletal muscle, aging, sarcopenia, neuromuscular junction, mesenchymal progenitor
Research period： 2023.3
Papers
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Transcriptome analysis of mesenchymal stromal cells of the large and small intestinal smooth muscle layers reveals a unique gastrontestinal stromal signature. Reviewed International journal
Chaen T., Kurosawa T., Kishi K., Kaji N., Ikemoto-Uezumi M., Uezumi A., Hori M.
Biochem Biophys Rep. 2023.4
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Tbx1 Regulates Inherited Metabolic and Myogenic Abilities of Progenitor Cells Derived from Slow- and Fast-type Muscle. Reviewed International journal
Motohashi N, Uezumi A, Asakura A, Ikemoto-Uezumi M, Mori S, Mizunoe Y, Takashima R, Miyagoe-Suzuki Y, Takeda S, Shigemoto K
Cell Death Differ 1900
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Whole-mount immunofluorescence staining of mesenchymal progenitors in murine plantaris muscle. Reviewed International journal
Kurosawa T, Ikemoto-Uezumi M, Kaneshige A, Fukada S, Uezumi A
STAR Protocols 1900
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Detection of muscle stem cell-derived myonuclei in murine overloaded muscles. Reviewed International journal
Kaneshige A, Kaji T, Saito H, Higashimoto T, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Uezumi A, Fukada S
STAR Protocols 1900
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Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation. Reviewed International journal
Yoshimoto Y, Uezumi A, Ikemoto-Uezumi M, Tanaka K, Yu X, Kurosawa T, Yambe S, Maehara K, Ohkawa Y, Sotomaru Y, Shukunami C
Front Cell Dev Biol 1900
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Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. Reviewed International journal
Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Toyoda M, Kanazawa N, Nakazawa T, Morita M, Tsuchida K, Uezumi A
Aging Cell 1900
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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load. Reviewed International journal
Kaneshige A, Kaji T, Zhang L, Saito H, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Tsujikawa K, Seno S, Hori M, Saito Y, Matozaki T, Maehara K, Ohkawa Y, Potente M, Watanabe S, Braun T, Uezumi A, Fukada S
Cell Stem Cell 1900
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Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice. Reviewed International journal
Minato K, Yoshimoto Y, Kurosawa T, Watanabe K, Kawashima H, Ikemoto-Uezumi M, Uezumi A
Int J Mol Sci 1900
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Transgenic expression of Bmp3b in mesenchymal progenitors mitigates age-related muscle mass loss and neuromuscular junction degeneration. Reviewed International journal
Kurosawa T, Minato K, Ikemoto-Uezumi M, Hino J, Tsuchida K, Uezumi A
Int J Mol Sci 1900
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Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNFα. Reviewed International journal
1900
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Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia. Reviewed International journal
Uezumi A, Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Nakatani M, Hitachi K, Yamaguchi H, Wakatsuki S, Araki T, Morita M, Yamada H, Toyoda M, Kanazawa N, Nakazawa T, Hino J, Fukada SI, Tsuchida K
J Clin Invest 1900
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Methods for accurate assessment of myofiber maturity during skeletal muscle regeneration. Reviewed International journal
Yoshimoto Y, Ikemoto-Uezumi M, Hitachi K, Fukada SI, Uezumi A
Front Cell Dev Biol 1900
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The CalcR-PKA-Yap1 axis is critical for maintaining quiescence in muscle stem cells. Reviewed International journal
Zhang L, Noguchi Y, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI
Cell Rep 1900
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Reduced expression of calcitonin receptor is closely associated with age-related loss of the muscle stem cell pool. Reviewed International journal
Ikemoto-Uezumi M, Uezumi A, Zhang L, Zhou H, Hashimoto N, Okamura K, Matsui Y, Tsukazaki K, Hosoyama T, Nakatani M, Morita M, Yamada H, Tsuchida K, Fukada SI
JCSM Rapid Commun 1900
Books
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Analyses of Mesenchymal Progenitors in Skeletal Muscle by Fluorescence-Activated Cell Sorting and Tissue Clearing.
Ikemoto-Uezumi M., Kurosawa T., Minato K., Uezumi A.
Methods Mol Biol. 2023.5
Presentations
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Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. Invited International conference
Madoka Uezumi
1st Symposium on "Skeletal muscle cells in Growth and Disease" 2023.5
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間葉系前駆細胞の不均一性が支える筋健全性維持メカニズムの解明．
長谷川 優花，上住 円，林 晋一郎，野口 悟，西野 一三，黒澤 珠希，二川 健，上住 聡芳
第9回日本筋学会学術集会 2023.8
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筋特異的ノックアウトマウスを用いたミトコンドリアアコニターゼの機能解析．
二川 健，岸田 昂大，高田 実穂，榊原 伊織，今井 祐記，上住 円，上住 聡芳
第9回日本筋学会学術集会 2023.8
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ヒト筋管細胞を用いた筋肥大作用を有する天然由来生理活性物質の同定．
上住 円，黒澤 珠希，布川 朋也，二川 健，上住 聡芳
第9回日本筋学会学術集会 2023.8
MISC
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サルコペニアの発症機序．
上住 円，上住 聡芳
別冊・医学のあゆみ 2023.10
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骨格筋〜臓器・疾患と線維化（症）〜．
上住 円，上住 聡芳
別冊・実験医学 2023.10
Professional Memberships
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日本筋学会
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日本再生医療学会
Academic Activities
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Screening of academic papers
Role(s)： Peer review
2023
Research Projects
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サルコペニアおよび神経筋疾患の新規治療法開発
2023.3
Authorship：Principal investigator
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サルコペニアおよび神経筋疾患の新規治療法開発
2022 - 2024
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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筋再生システムの老化を若返らせる分子機構
2019 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(B)
Authorship：Coinvestigator(s) Grant type：Scientific research funding
Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.
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2023 徳島大学大学院医歯薬学研究部 Classification:Part-time lecturer Domestic/International Classification:Japan