Updated on 2024/06/10

Information

 

写真a

 
YAMAMOTO SHOTA
 
Organization
Medical Institute of Bioregulation Medical Research Center for High Depth Omics Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
External link

Degree

  • Ph.D.

Research Interests・Research Keywords

  • Research theme:Understanding the brain based on lipid metabolism

    Keyword:lipid metabolism, central nervous system

    Research period: 2023.4

Awards

  • 2023年度海外学会等参加費用援助

    2022.12   公益信託 医用薬物研究奨励富岳基金  

  • 第34回(2022年度)加藤記念国際交流助成

    2022.10   公益財団法人 加藤バイオサイエンス振興財団  

  • Postdoctoral Award

    2019.6  

  • 優秀発表賞

    2018.3   日本薬学会第138年会  

  • 優秀発表賞

    2016.11   第69回日本薬理学会西南部会  

Papers

  • Lipid in microglial biology - from material to mediator. International journal

    Shota Yamamoto, Takahiro Masuda

    Inflammation and regeneration   43 ( 1 )   38 - 38   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s41232-023-00289-z

  • Profiling of fatty acid metabolism in the dorsal root ganglion after peripheral nerve injury. International journal

    Shota Yamamoto, Tomomi Hashidate-Yoshida, Takao Shimizu, Hideo Shindou

    Frontiers in pain research (Lausanne, Switzerland)   3   948689 - 948689   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fpain.2022.948689

  • Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity. International journal

    Wei Zhang, Ryosuke Matsukane, Nobuaki Egashira, Yuichi Tsuchiya, Rao Fu, Shota Yamamoto, Takeshi Hirota, Ichiro Ieiri

    Toxicology and applied pharmacology   449   116112 - 116112   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.taap.2022.116112

  • Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses. International journal

    Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology   36 ( 4 )   e22236   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fj.202101678R

  • Lipid signaling in chemotherapy-induced peripheral neuropathy

    Shota Yamamoto, Nobuaki Egashira

    Current Opinion in Toxicology   28   1 - 6   2021.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cotox.2021.08.007

  • Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats.

    Nobuaki Egashira, Yu Goto, Ryota Takahashi, Hikari Iba, Shota Yamamoto, Takuya Watanabe, Kaori Kubota, Takehiro Kawashiri, Chise Taniguchi, Shutaro Katsurabayashi, Katsunori Iwasaki

    Journal of pharmacological sciences   147 ( 1 )   114 - 117   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jphs.2021.06.004

  • Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy

    Shota Yamamoto, Nobuaki Egashira

    International Journal of Molecular Sciences   22 ( 2 )   888 - 888   2021.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms22020888

  • Drug Repositioning for the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Mechanism- and Screening-Based Strategy

    Shota Yamamoto, Nobuaki Egashira

    Frontiers in Pharmacology   11   2021.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fphar.2020.607780

  • Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development. International journal

    William J Valentine, Tomomi Hashidate-Yoshida, Shota Yamamoto, Hideo Shindou

    Advances in experimental medicine and biology   1274   5 - 27   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/978-3-030-50621-6_2

  • Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2) incorporates DHA into phospholipids and has possible functions for fatty acid-induced cell death. International journal

    Miki Eto, Hideo Shindou, Shota Yamamoto, Miwa Tamura-Nakano, Takao Shimizu

    Biochemical and biophysical research communications   526 ( 1 )   246 - 252   2020.5

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    Language:English  

    DOI: 10.1016/j.bbrc.2020.03.074

  • New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats.

    Yamamoto S, Yamashita T, Ito M, Caaveiro JMM, Egashira N, Tozaki-Saitoh H, Tsuda M

    International journal of cancer   145 ( 8 )   2107 - 2113   2019.10

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    Language:Others  

    New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats.

    DOI: 10.1002/ijc.32043

  • Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats.

    Yamamoto S, Egashira N, Tsuda M, Masuda S

    Journal of pharmacological sciences   138 ( 3 )   214 - 217   2018.11

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    Language:Others  

    Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats.

    DOI: 10.1016/j.jphs.2018.10.006

  • Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug

    Shota Yamamoto, Soichiro Ushio, Nobuaki Egashira, Takehiro Kawashiri, Shohei Mitsuyasu, Hitomi Higuchi, Nana Ozawa, Ken Masuguchi, Yuko Ono, Satohiro Masuda

    SCIENTIFIC REPORTS   7 ( 1 )   9661   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-08891-1

  • Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury

    Tomohiro Yamashita, Shota Yamamoto, Jiaming Zhang, Miho Kometani, Daisuke Tomiyama, Keita Kohno, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda

    PLOS ONE   11 ( 10 )   e0165189   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0165189

  • Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor.

    129 ( 3 )   196 - 199   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jphs.2015.09.004

  • Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats

    Shota Yamamoto, Takehiro Kawashiri, Hitomi Higuchi, Kuniaki Tsutsumi, Soichiro Ushio, Takanori Kaname, Masafumi Shirahama, Nobuaki Egashira

    JOURNAL OF PHARMACOLOGICAL SCIENCES   129 ( 1 )   43 - 50   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jphs.2015.08.006

  • Inhibition of Ca2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats

    Masafumi Shirahama, Soichiro Ushio, Nobuaki Egashira, Shota Yamamoto, Hikaru Sada, Ken Masuguchi, Takehiro Kawashiri, Ryozo Oishi

    MOLECULAR PAIN   8   26   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1744-8069-8-26

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MISC

  • 血小板活性化因子(PAF)シグナル遮断による神経障害性がん疼痛の克服—PAF-Pain Loop遮断を標的とした新規カテゴリー鎮痛薬開発へ

    山本 将大, 進藤 英雄

    医学のあゆみ   2019.11

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    Language:Others  

Professional Memberships

  • 北米神経科学学会

  • THE JAPANESE BIOCHEMICAL SOCIETY

  • THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS

  • 日本緩和医療薬学会

  • JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES

  • THE PHARMACEUTICAL SOCIETY OF JAPAN

  • THE JAPANESE PHARMACOLOGICAL SOCIETY

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Research Projects

  • アラキドン酸含有リン脂質が担う難治性疼痛の新しい病態メカニズム

    Grant number:23K06820  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アラキドン酸含有リン脂質が担う神経障害性疼痛の新しい病態メカニズム

    2022

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    Grant type:Donation

  • 「生体膜リン脂質-膜タンパク質連関」から紐解く神経障害性疼痛発症メカニズムの解明

    Grant number:21J00759  2021 - 2023

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新しい疼痛制御分子「リン脂質生合成酵素」を標的にしたドラッグリポジショニング研究

    Grant number:21K15309  2021 - 2022

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 神経障害性疼痛におけるω6系脂肪酸含有リン脂質の役割解明と疼痛治療への応用

    2021

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    Grant type:Donation

  • ミクログリアにおける膜リン脂質ダイナミクスの調節機構解明と難治性疼痛治療への応用

    2021

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    Grant type:Donation

  • 生体膜リン脂質生合成酵素群に注目した難治性疼痛に対する新規治療標的の同定

    2020

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    Grant type:Donation

  • 生体膜リン脂質操作による神経障害性疼痛の発症維持メカニズムの解明

    Grant number:19K16938  2019 - 2020

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ハイスループットスクリーニングによる抗がん薬誘発末梢神経障害の新規保護薬の探索研究

    2017

    アカデミックチャレンジ2017年度

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

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