Updated on 2024/07/28

Information

 

写真a

 
KANO ARIHIRO
 
Organization
Institute for Materials Chemistry and Engineering Department of Fundamental Organic Chemistry Associate Professor
Interdisciplinary Graduate School of Engineering Sciences Department of Interdisciplinary Engineering Sciences(Concurrent)
Title
Associate Professor
Contact information
メールアドレス
Profile
1. Interferon-gamma (IFN-gamma), an inflammatory cytokine and T-cell activator, was found to induce apoptosis in parenchymal cells, which play a major role in the liver, and the cancer suppressor factors p53 and IRF-1 have been implicated in the mechanism of this action. I have also focused on STATs (Signal Transducers and Activators of Transcription), which are responsible for the intracellular signalling of inflammatory cytokines, and are analysing their functions and conducting applied research targeting them. The results of these studies may lead to a better understanding of the pathogenesis of fulminant or chronic hepatitis, which is thought to be caused by an abnormal immune system, and to its treatment. In addition, he has conducted research focusing on sinusoidal endothelial cells in the liver and found that these cells suppress the excessive activation of immune cells. 2. It is now widely accepted that while the immune system monitors cancer and prevents its emergence and proliferation (Immune Surveillance), cancer evades the surveillance system in various ways. Indeed, it has been reported that cancer suppresses the immune system in various ways, including reduced expression of cancer antigens and human leukaemic antigen (HLA), loss of cell death-inducing signals and co-stimulatory molecules, induction of regulatory T cells and undifferentiated bone marrow-derived cells, and production of immunosuppressive cytokines. In addition, immune checkpoint inhibitors that suppress regulatory T cells have been commercialised for the treatment of malignant melanoma, and their remarkable efficacy is still being used in a growing number of indications. I found that many cancer cells have an activity to inhibit IFN-γ production through the co-culture of mouse spleen cells with various cancer cells and the analysis of the culture supernatant. In a study using splenocytes from mice transplanted with 4T1 breast cancer cells, I found that the inhibition of IFN-γ production by the culture supernatant of cancer cells increased with the passage of more days after transplantation, i.e. with the growth of the tumour. Therefore, a search for immunosuppressive substances secreted by 4T1 cells was conducted. As a result of the experiments, 18 candidate proteins have been found so far. Functional analysis of the main immuno-related functions of these will be carried out in the future. 3 Adenine Nucleotide Translocase (ANT) is a protein present in the inner mitochondrial membrane that mediates the exchange reaction between cytosolic ADP and mitochondria-synthesised ATP and is also reported to be involved in the execution of apoptosis. ANTs comprise a family of four subtypes in humans, but the relationship of these subtypes to apoptosis in particular remains unclear. We are therefore analysing the mechanisms of ANT subtypes and apoptosis execution using siRNA and genome editing techniques.
External link

Degree

  • Ph. D.

Research History

  • 平成9年4〜11月  三菱化学生命科学研究所 特別研究員 平成14年3月〜平成17年2月  科学技術振興事業団(現独立行政法人科学技術振興機構)研究員

    平成9年4〜11月  三菱化学生命科学研究所 特別研究員 平成14年3月〜平成17年2月  科学技術振興事業団(現独立行政法人科学技術振興機構)研究員

  • 平成9年11〜平成10年8月  東京工業大学大学院生命理工学研究科赤池研究室 博士研究員 平成10年9月〜平成14年2月  Yale大学医学部病理学科 ポストドクトラルアソシエイト

Research Interests・Research Keywords

  • Research theme:Study of mitochondria ADP/ATP translocase

    Keyword:ADP, ATP, cancer, apoptosis

    Research period: 2021.11

  • Research theme:Photo dynamic therapy by Cancer receptor-ligand DDS

    Keyword:Photo Dynamic Therapy, DDS, cancer, receptor, ligand

    Research period: 2021.6

  • Research theme:Targeting on immunosuppresive cells by photo dynamic probes for cancer therapy

    Keyword:Immune Suppression, Spleen, Cancer cells、Photo Dynamic Therapy

    Research period: 2020.4 - 2021.6

  • Research theme:Cancer selective cytotoxicity of mitochondrial inhibitor and its application

    Keyword:Mitochondrial inhibitor, Glycolysis, ATP, Warburg Effect, Cancer

    Research period: 2014.4 - 2019.6

  • Research theme:Complex formation of the tumor-directed graft polymer and anticancer agents and its application to the cancer therapy

    Keyword:water soluble macromolecule, DDS, photo dynamic therapy

    Research period: 2008.4 - 2013.3

  • Research theme:Search for immunoregulatory substances by splenocyte culture system

    Keyword:Immune Suppression, Splenocytes, LPS, Liver Sinusoidal Endothelial cells, Cancer cells

    Research period: 2008.4

  • Research theme:Analysis of the dynamics of water soluble macromolecules in vivo and application to tumor therapy

    Keyword:water soluble macromolecule, DDS, EPR

    Research period: 2007.4 - 2011.3

  • Research theme:Delivery of siRNA to tumors by passive targetting

    Keyword:siRNA, PLL-PEG, EPR

    Research period: 2005.4 - 2009.10

  • Research theme:The role of liver in immune response and its control

    Keyword:liver, liver sinusoidal endothelial cell, immunology, hyaluronan

    Research period: 2003.4 - 2009.3

  • Research theme:Analysis of apoptosis induced by IFN-gamma

    Keyword:Hepatocyte, Interferon-gamma, Apoptosis, SV40 large T antigen,

    Research period: 2002.4

  • Research theme:Conditional knockout mice of STAT3

    Keyword:STAT-3, Knockout mouse, Endothelial cell, Endotoxin, Immune suppression

    Research period: 1998.9 - 2002.2

Papers

  • Tumor cell secretion of soluble factor(s) for specific immunosuppression Reviewed International journal

    Arihiro Kano

    SCIENTIFIC REPORTS   5   2015.3

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    DOI: 10.1038/srep08913

  • Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy Reviewed International journal

    167 ( 32 )   2013.3

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  • Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates Reviewed International journal

    Tsutomu Ishihara, Arihiro Kano, Kentaro Obara, Minako Saito, Xuesi Chen, Tae Gwan Park,Toshihiro Akaike, Atsushi Maruyama

    J. Control. Release   155 ( 1 )   2011.10

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  • Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. Reviewed International journal

    Kano A., Wolfgang M.J., Gao Q., Jacoby J., Chai G.X., Hansen W., Iwamoto Y, Pober J.S., Flavell R.A., Fu XY.

    J Exp Med.   2003.1

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  • STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality Reviewed International journal

    Welte T., Zhang S.S., Wang T., Zhang Z., Hesslein D.G., Yin Z., Kano A., Iwamoto Y., Li E., Craft J.E., Bothwell A.L., Fikrig E., Koni P.A., Flavell R.A., Fu XY.

    Proc Natl Acad Sci U S A.   2003.1

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  • IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis of primary cultured hepatocytes. Biochem Biophys Res Commun. Reviewed International journal

    Kano A., Haruyama T., Akaike T., Watanabe Y.

    Biochem Biophys Res Commun.   1999.1

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  • Design and synthesis of strong root gravitropism inhibitors with no concomitant growth inhibition Reviewed International journal

    Nishimura, Takeshi; Makigawa, Saki; Sun, Jun; Kodama, Kozue; Sugiyama, Hiromi; Matsumoto, Kenji; Iwata, Takayuki; Wasano, Naoya; Kano, Arihiro; Morita, Miyo Terao; Fujii, Yoshiharu; Shindo, Mitsuru

    Scientific Reports   13 ( 1 )   5173   2023.3

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    DOI: 10.1038/s41598-023-32063-z

  • Design and chemical synthesis of root gravitropism inhibitors: Bridged analogues of ku-76 have more potent activity Reviewed International journal

    Shindo, Mitsuru; Makigawa, Saki; Kodama, Kozue; Sugiyama, Hiromi; Matsumoto, Kenji; Iwata, Takayuki; Wasano, Naoya; Kano, Arihiro; Morita, Miyo Terao; Fujii, Yoshiharu

    Phytochemistry   179   2020.11

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    DOI: 10.1016/j.phytochem.2020.112508

  • Essential structural features of (2Z,4E)-5-phenylpenta-2,4-dienoic acid for inhibition of root gravitropism Reviewed

    Mitsuru Shindo, Saki Makigawa, Kenji Matsumoto, Takayuki Iwata, Naoya Wasano, Arihiro Kano, Miyo Terao Morita, Yoshiharu Fujii

    Phytochemistry   172   2020.4

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    DOI: 10.1016/j.phytochem.2020.112287

  • Essential structural features of (2Z,4E)-5-phenylpenta-2,4-dienoic acid for inhibition of root gravitropism Reviewed International journal

    Shindo, Mitsuru; Makigawa, Saki; Matsumoto, Kenji; Iwata, Takayuki; Wasano, Naoya; Kano, Arihiro; Morita, Miyo Terao; Fujii, Yoshiharu

    Phytochemistry   172   2020.4

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    DOI: 10.1016/j.phytochem.2020.112287

  • Bongkrekic acid facilitates glycolysis in cultured cells and induces cell death under low glucose conditions Reviewed International journal

    Arihiro Kano, #Takuma Iwasaki, Mitsuru Shindo

    Biochemistry and Biophysics Reports   20   2019.12

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    DOI: 10.1016/j.bbrep.2019.100683

  • Synthesis and evaluation of simplified functionalized bongkrekic acid analogs Reviewed International journal

    #Satoshi Fujita, #Masaki Suyama, Kenji Matsumoto, @Atsushi Yamamoto, @Takenori Yamamoto, @Yuka Hiroshima, Takayuki Iwata, ArihiroKano, @Yasuo Shinohara, Mitsuru Shindo

    Tetrahedron   74 ( 9 )   962 - 969   2018.3

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    DOI: 10.1016/j.tet.2018.01.018

  • Bongkrekic Acid induces Selective Cytotoxicity in Tumor Cells, revealed by CCK-8 Reviewed International journal

    Arihiro Kano, #Moses Kibunja Kamita, #Takuma Iwasaki, Mitsuru Shindo

    Evergreen   04 ( 02/03 )   23 - 27   2017.9

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  • Macrophage Colony-Stimulating Factor mediates its Immunosuppressive Activity through the Emerging Myeloid Cells during Tumor Progression Reviewed International journal

    #Moses Kamita, Mitsuru Shindo, Arihiro Kano

    Evergreen   04 ( 02/03 )   18 - 22   2017.9

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  • Synthesis of fluorescent molecular probes based on cis-cinnamic acid and molecular imaging of lettuce roots Invited Reviewed International journal

    Tetrahedron   72   6492 - 6498   2016.10

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    DOI: 10.1016/j.tet.2016.08.060

  • Efficient Total Synthesis of Bongkrekic Acid and Apoptosis Inhibitory Activity of Its Analogues Reviewed International journal

    CHEMISTRY-A EUROPEAN JOURNAL   21 ( 32 )   11590 - 11602   2015.8

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    DOI: 10.1002/chem.201501304

  • Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine Reviewed International journal

    Chen, Jie, Tian, Huayu, Dong, Xuan, Guo, Zhaopei, Jiao, Zixue, Li, Feifan, Arihiro Kano, Maruyama, Atsushi;, Chen, Xuesi

    Chemistry Letters   13 ( 10 )   2013.10

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    DOI: 10.1002/mabi.201300211

  • Reversibly Cross-linked Polymeric Micelles Formed by Autonomously Exchangeable Dynamic Covalent Bonds Reviewed International journal

    Nishihara, M., Imato, K., Irie, A., Kanehara, T., Kano, A., Maruyama, A., Takahara, A., Otsuka, H.

    Chemistry Letters   42 ( 4 )   2013.4

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  • Design of UCST polymers for chilling capture of proteins Reviewed International journal

    Shimada, N., Kano, A., Maruyama, A.

    Chem Commun   49 ( 5 )   2012.12

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  • Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery Reviewed International journal

    Shimoda, A., Sawada, S., Kano, A., Maruyama, A., Moquin, A., Winnik, F.M., Akiyoshi, K.

    Colloids and surfaces. B, Biointerfaces   99   2012.11

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  • Preparation of Cationic Comb-Type Copolymer Having Tetra-Alkylammonium Groups and its Interaction with DNA Reviewed International journal

    Rui Moriyama, Junji Mochida, Asako Yamayoshi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Current Nanoscience   7 ( 6 )   2011.12

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    DOI: doi.org/10.2174/157341311798220600

  • Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles Reviewed International journal

    Ohya, Y., Takeda, S., Shibata, Y., Ouchi, T., Kano, A., Iwata, T., Mochizuki, S., Taniwaki, Y., Maruyama, A

    J Control Release   155 ( 1 )   2011.10

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  • Ureido-Derivatized Polymers Based on Both Poly(allylurea) and Poly(L-citrulline) Exhibit UCST-Type Phase Transition Behavior under Physiologically Relevant Conditions Reviewed International journal

    Naohiko Shimada, Haruka Ino, Kenji Maie, Miki Nakayama, Arihiro Kano, Atsushi Maruyama

    Biomacromolecules   10 ( 12 )   2011.10

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    DOI: .doi.org/10.1021/bm2010752

  • Enhanced cell uptake via non-covalent decollation of a single-walled carbon nanotube-DNA hybrid with polyethylene glycol-grafted poly(l-lysine) labeled with an Alexa-dye and its efficient uptake in a cancer cell Reviewed International journal

    Fujigaya, T., Yamamoto, Y., Kano, A., Maruyama, A., Nakashima, N.

    Nanoscale   3 ( 10 )   2011.9

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  • In vitro and in vivo gene delivery using polyethylenimine-poly(hydroxyethyl glutamine) as a non-viral carrier Reviewed International journal

    Chen, J., Tian, H., Kano, A., Maruyama, A., Chen, X., and Park, T.G.,

    J. Controlled Release   2011.8

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  • The Role of Cationic Comb-type Copolymers in Chaperoning DNA Annealing. Reviewed International journal

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Biomaterials   32 ( 30 )   2011.3

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  • DNA assembly and re-assembly activated by cationic comb-type copolymer Reviewed International journal

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Biomaterials   32 ( 9 )   2011.3

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  • Cationic Comb-type Copolymers Do Not Cause Collapse but Shrinkage of DNA Molecules Reviewed International journal

    Naotaka Sonda, Masanori Hirano, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, and Atsushi Maruyama

    Chemistry letters   40   2011.2

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  • Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA Reviewed International journal

    Kano, A., Moriyama, K., Yamano, T., Nakamura, I., Shimada, N., and Maruyama, A.

    J Control Release   149   2011.2

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  • Cationic Graft Copolymer as a DNA B-Z Transition Inducer: Effect of Copolymer Structure Reviewed International journal

    Shimada, N., Yamamoto, M., Kano, A., and Maruyama, A.

    Biomacromolecules   11 ( 11 )   2010.11

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  • A highly efficient siRNA carrier of PBLG modified hyperbranched PEI Reviewed International journal

    Chen, J., Tian, H., Guo, Z., Xia, J., Kano, A., Maruyama, A., Jing, X., and Chen, X.

    Macromol Biosci   9 ( 12 )   2009.12

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  • Design of cationic graft copolymers as a potential inducer of B-Z transition Reviewed International journal

    Shimada, N., Kano, A., and Maruyama, A.

    Nucleic Acids Symp Ser   53   2009.9

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  • Cationic comb-type copolymer as a nucleic acid chaperone for DNA quadruplex Reviewed International journal

    Moriyama, R., Shimada, N., Kano, A., and Maruyama, A.

    Nucleic Acids Symp Ser   53   2009.9

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  • Novel Silver-Loaded Semi-Interpenetrating Polymer Network Gel Films with Antibacterial Activity Reviewed International journal

    Thatiparti, T.R., Kano, A., Maruyama, A., and Takahara, A.

    Journal of Polymer Science Part a-Polymer Chemistry   47 ( 19 )   2009.8

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  • Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone Reviewed International journal

    Morimoto, N., Tamada, J., Sawada, S., Shimada, N., Kano, A., Maruyama, A., and Akiyoshi, K.

    Chemistry Letters   38 ( 5 )   2009.4

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  • Uptake of enzymatically-digested hyaluronan by endothelial liver cells in vivo and in vitro Reviewed International journal

    S. Mochizuki, A. Kano, N. Shimada, A. Maruyama

    J. Biomater. Sci. Polymer Edn   20   2009.1

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  • Synthesis and characterization of semi-interpenetrating polymer networks based on polyurethane and N-isopropylacrylamide for wound dressing Reviewed International journal

    Reddy, T.T., Kano, A., Maruyama, A., Hadano, M., and Takahara, A.

    J Biomed Mater Res B Appl Biomater   88 ( 1 )   2008.9

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  • Polymer brush-stabilized polyplex for a siRNA carrier with long blood circulatory half-life Reviewed International journal

    A. Kano, T. Yamano, S. W. Choi, A. Maruyama

    Advanced Materials Research   2008.7

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  • Kinetic Effect of Cationic Comb-type Copolymers on DNA Hybridization Reviewed International journal

    A. Maruyama, L. Wu, N. Shimada and A. Kano

    Advanced Materials Research   2008.7

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  • Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control Reviewed International journal

    T. T. Reddy, A. Kano, A. Maruyama, M. Hadano and A. Takahara

    Biomacromolecules   2008.4

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  • Identification of de novo STAT3 target gene in liver regeneration Reviewed International journal

    H. Q. Zhang, S. Haga, M. Fukai, Y. Oikawa, H. Inoue, W. Ogawa, A. Kano, A. Maruyama, X. Y. Fu, S. Todo, S. Enosawa and M. Ozaki

    Hepatol Res   2008.4

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  • Activation of DNA strand exchange by cationic comb-type copolymers: effect of cationic moieties of the copolymers Reviewed International journal

    S. W. Choi, A. Kano and A. Maruyama

    Nucleic Acids Res   2008.1

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  • Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery Reviewed International journal

    A. Moh, Y. Iwamoto, G. X. Chai, S. S. Zhang, A. Kano, D. D. Yang, W. Zhang, J. Wang, J. J. Jacoby, B. Gao, R. A. Flavell and X. Y. Fu

    Lab Invest   2007.10

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  • Effect of cationic comb-type copolymer on quadruplex folding of human telomeric DNA Reviewed International journal

    N. Makita, S. W. Choi, A. Kano, A. Yamayoshi, T. Akaike and A. Maruyama

    Nucleosides Nucleotides Nucleic Acids   2007.8

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  • Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life Reviewed International journal

    A. Sato, S. W. Choi, M. Hirai, A. Yamayoshi, R. Moriyama, T. Yamano, M. Takagi, A. Kano, A. Shimamoto and A. Maruyama

    J Control Release   2007.3

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  • Spectroscopic investigation of cationic comb-type copolymers/DNA interaction: interpolyelectrolyte complex enhancement synchronized with DNA hybridization. Reviewed International journal

    Sato Y, Moriyama R, Choi SW, Kano A, Maruyama A

    Langmuir   2007.1

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  • Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization Reviewed International journal

    L. Wu, N. Shimada, A. Kano and A. Maruyama

    Nucleic Acids Symp Ser (Oxf)   2007.1

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  • Novel analysis for single nucleotide polymorphism using cationic comb-type copolymers Reviewed International journal

    N. Shimada, K. Muraki, T. Anai, A. Kano and A. Maruyama.

    Nucleic Acids Symp Ser (Oxf)   2007.1

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  • Cationic comb-type copolymers for boosting DNA-fueled nanomachines. Reviewed International journal

    Choi SW, Makita N, Inoue S, Lesoil C, Yamayoshi A, Kano A, Akaike T, Maruyama A.

    Nano Lett.   2006.12

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  • Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei. Reviewed International journal

    Yamashita A, Yui N, Ooya T, Kano A, Maruyama A, Akita H, Kogure K, Harashima H.

    Nat Protoc.   2006.12

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  • Hyaluronan conjugation of antigenic protein to modify immunogenic information Reviewed International journal

    S. Mochizuki, A. Kano, A. Yamayoshi, A. Maruyama

    Science and Technology of Advanced Materials   2006.10

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  • Biocleavable Polyrotaxane-Plasmid DNA Polyplex for Enhanced Gene Delivery Reviewed International journal

    Ooya, Tooru; Choi, Hak Soo; Yamashita, Atsushi; Yui, Nobuhiko; Sugaya, Yuko; Kano, Arihiro; Maruyama, Atsushi; Akita, Hidetaka; Ito, Rie; Kogure, Kentaro; Harashima, Hideyoshi

    Journal of the American Chemical Society   2006.3

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  • Structural effect of cationic copolymers on nucleic acid-chaperoning activity Reviewed International journal

    K. Takada, S. W. Choi, A. Yamayoshi, A. Kano and A. Maruyama

    Nucleic Acids Symp Ser (Oxf)   2006.1

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  • pH-sensing nano-crystals of carbonate apatite: effects on intracellular delivery and release of DNA for efficient expression into mammalian cells Reviewed International journal

    E. H. Chowdhury, A. Maruyama, A. Kano, M. Nagaoka, M. Kotaka, S. Hirose, M. Kunou and T. Akaike

    Gene   2006.1

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  • Single-base mismatch recognition using partially double-stranded probes having various lengths Reviewed International journal

    D. Ishii, K. Muraki, A. Kano, A. Yamayoshi and A. Maruyama

    Nucleic Acids Symp Ser (Oxf)   2006.1

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  • B-Z DNA Transition Triggered by a Cationic Comb-Type Copolymer Reviewed International journal

    Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Advanced Functional Materials   19 ( 22 )   2005.10

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  • The molecular structure effect of cationic comb-type copolymers on nucleic acid chaperone activity Reviewed International journal

    S. W. Choi, K. Takada, J. Mochida, A. Yamayosh, A. Kano and A. Maruyama

    Nucleic Acids Symp Ser (Oxf)   2005.1

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  • Discrimination of single nucleotide polymorphisms by strand exchange assay using partially double-stranded probes Reviewed International journal

    K. Hirata, D. Ishii, A. Kano, A. Yamayoshi, T. Akaike and A. Maruyama

    Nucleic Acids Symp Ser (Oxf)   2005.1

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  • Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alphas. Reviewed International journal

    Ushijima R., Sakaguchi N., Kano A., Maruyama A., Miyamoto Y., Sekimoto T., Yoneda Y., Ogino K., Tachibana T.

    Biochemical and Biophysical Research Communications   330 ( 3 )   880 - 886   2005.1

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    DOI: 10.1016/j.bbrc.2005.03.063

  • Modulation of highly ordered structures of human telomeric sequence by cationic copolymers Reviewed International journal

    N. Makita, A. Kano, A. Yamayoshi, T. Akaike and A. Maruyama

    Nucleic Acids Symp Ser (Oxf)   2005.1

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  • STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation. Reviewed International journal

    Zhang SS, Liu MG, Kano A, Zhang C, Fu XY, Barnstable CJ

    Exp Eye Res   2005.1

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  • Synergistic Stabilization of Nucleic Acid Assembly by 2′-O,4′-C-Methylene-Bridged Nucleic Acid Modification and Additions of Comb-Type Cationic Copolymers Reviewed International journal

    2005.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Nucleation-synchronized strand displacement for highly sensitive DNA analysis Reviewed International journal

    K. Hirata, Y. Sato, A. Kano, T. Akaike and A. Maruyama

    Nucleic Acids Symp Ser (Oxf)   2004.1

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  • Investigation of DNA strand exchange mechanisms mediated by cationic polymers Reviewed International journal

    Y. Sato, W. J. Kim, S. W. Choi, M. Saito, A. Kano, T. Akaike and A. Maruyama

    Nucleic Acids Res Suppl   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Preparation of dendritic graft copolymer consisting of poly-(L-lysine) and arabinogalactan as a hepatocyte specific DNA carrier Reviewed International journal

    J. U. Park, T. Ishihara, A. Kano, T. Akaike and A. Maruyama

    Prep Biochem Biotechnol   1999.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Analysis of IFN-gamma-induced cell cycle arrest and cell death in hepatocytes Reviewed International journal

    A. Kano, Y. Watanabe, N. Takeda, S. Aizawa and T. Akaike

    J Biochem   1997.4

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Presentations

  • IFN-γ産生を指標にした乳がん細胞4T1担持マウスの免疫抑制性の解析 Invited

    第80回日本インターフェロン・サイトカイン学会学術集会  2015.7 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

    免疫システムががんの出現を監視(Immunosurveillance)しその増大を防ぐ一方、がんは監視システムから種々の方法で逃れていると考えられている。そこで培養がん細胞が脾臓細胞の培養時に観察されるIFN-γ産生への影響を検討した結果、多くのがん細胞がそれを抑制する事が判明した。本研究では同種同系移植が可能な乳がん細胞4T1に絞り、移植による脾臓細胞、およびそのIFN-γ産生への影響を調べた。またIFN-γ産生を指標にし、4T1細胞が分泌する免疫抑制性因子の同定を進めた。

  • マウス乳がん細胞4T1が分泌する免疫抑制因子の解析

    日本生化学会  2014.10 

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    Event date: 2014.10

    Language:Japanese  

    Venue:京都市   Country:Japan  

    免疫システムががんの出現を監視し、その増大を防ぐ一方、がんは免疫による監視システムから様々な方法で逃れているという考えは、Cancer Immunoediting というコンセプトで現在受け入れられている。本研究では乳がん細胞 4T1 を同種同系の Balb/c マウスに移植後、脾細胞を単離し、IFN-γ の産生量を ELISA 法にて測定することで、リンパ球の活性化状態を調べた。4T1 細胞移植後に脾臓細胞を分散させ2日間培養した結果、移植一週間をピークとして IFN-γ の著しい産生高進が観察され、その後徐々に減少し3週間以降は検出限界レベルとなることが判明した。移植一週間以降の IFN-γ 産生減少は脾臓増大に伴うリンパ球の相対的減少のためと推測された。つづいて分散脾細胞を 4T1 細胞と共培養した結果、当初の予想に反し、IFN-γ 産生は抑制され、4T1 細胞移植後の経過時間が長いほど強く抑制される結果となった。TNF-α 産生に変化は無かったことから、リンパ球の活性化が抑制されているものと考えられた。また 4T1 培養上清においても同様に IFN-γ 産生が抑制されたことから、4T1 細胞が分泌する何らかの液性因子がこの現象に関与しているものと考えられた。種々の検証の結果、10 ~ 100 kDa のタンパク質性の物質であることが判明した。そこで ELIS A法にて既知の抑制性サイトカインの産生を検証した結果、IL-10 は検出されず、またTGF-βは潜在型のみが検出された。この液性因子の同定を現在進めている。

  • IFN-gamma 誘導肝細胞死における caspase-12 の関与

    狩野有宏、丸山厚

    第28回日本分子生物学会  2005.12 

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    Venue:福岡   Country:Japan  

  • Inhibition of 2-deoxyglucose-induced apoptosis by bongkrekic acid

    2022.12 

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    Event date: 2023.12

    Language:Japanese  

    Country:Japan  

  • Establishment of adenine nucleotide translocase deficient cell lines and studies on its role in proliferation and apoptosis(アデニンヌクレオチド交換タンパク質欠損株の作成と増殖およびアポトーシスへの影響)

    狩野 有宏, #藤木 美穂

    第45回日本分子生物学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:English  

    Venue:幕張メッセ   Country:Japan  

    Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP, which is a key mechanism for oxidative phosphorylation in eukaryotic organisms. ANT consists of four isoforms in humans and three isoforms in mice (Ant3 is not expressed). The ANT1 gene is predominantly expressed in heart and muscle, and the ANT2 gene is mainly expressed in lymphoid cells and the liver. The ANT3 gene is expressed abundantly but at a low level, and ANT4 is only expressed in brain, liver, and testis. Interestingly, it has been reported that the ANT2 gene is abundantly expressed in cancer cells and aids in the importation of ATP produced by glycolysis from the cytosol to the mitochondria. The glycolytic ATP in mitochondria is hydrolyzed by F1F0-ATP synthase in a reverse reaction that produces a proton motive force, which maintains the mitochondrial membrane potential. However, it has been reported that ATP importation is independent of ANT in HepG2 and A549 cells (JBC. 2017; 292(41): 16969). The role of ANT in apoptosis has been also discussed through the part of the mitochondrial permeability pore. Such as ANT1 acts as a proapoptotic and ANT2 acts as an antiapoptotic protein. However, the mechanisms of ANT1, 2 in apoptosis induction and inhibition are unknown and the significance of them in tumor development and metastasis is not fully understood. For these aims, we have established Ant1 and 2 deficient cancer cells each and attempt to knock out both genes simultaneously by the CRISPR/Cas9 technique. In this meeting, we will report the results of apoptotic induction in these cell lines.

  • マウス4T1乳がん細胞培養上清中の免疫抑制性タンパク質の精製

    狩野 有宏

    第44回日本分子生物学会年会  2021.12 

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    Event date: 2021.12

    Language:Japanese  

    Venue:横浜 オンライン   Country:Japan  

    There are immune suppressive activities in the culture conditioned media of murine mammary carcinoma 4T1 cell, which are demonstrated by the suppression of the production of IFN-γ in splenocytes isolated from a 4T1 tumor-bearing mouse. M-CSF was identified as an IFN-gamma suppressive factor, however, it was thought that IFN-γ suppressive activities that were not due to M-CSF still existed in the 4T1-conditioned media. To identify the factors taking role of these activities, purification from the 4T1-conditiomed medium by liquid column chromatography and TOF-MS analysis was performed. However, despite several challenges, this attempt has not been succeeded yet. To assure the identification of the factors, further purification of the suppressive factors may be necessary. In this meeting, the result of the IFN-γ suppressive activities after the further purification by Blue Sepharose and ConA Sepharose will be reported.

  • マウス4T1乳がん細胞が分泌する免疫抑制性タンパク質の精製と同定

    狩野 有宏、新藤 充

    第43回日本分子生物学会年会  2020.12 

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    Event date: 2020.12

    Language:Japanese  

    Venue:オンライン   Country:Japan  

    We have observed immunosuppressive activities in a culture supernatant of several murine cancer cells. Among them, the conditioned media of mammary carcinoma 4T1 cells more suppress the production of IFN-γ of splenocytes when they are isolated from a 4T1 tumor-bearing mouse. These results suggested that some cells emerge in a spleen that are induced by the transplanted 4T1 tumor, which suppress IFN-γ production responding to the 4T1-conditioned media. Indeed, we have found M-CSF through the protein purification in the conditioned media of 4T1 cells based on the IFN-γ suppressing activity and increasing of CD115+ (M-CSF receptor) cells in the spleen after transplantation of 4T1 cells. We observe the apparent suppressing activity of IFN-γ on M-CSF in in vitro assay using splenocytes, however, the importance of these phenomenon on the tumor development has not been examined yet. Besides, unidentified IFN-γ suppressing factors still exist in the 4T1-conditioned media. In this study, we performed further purification of the suppressing factors in the 4T1-conditioned media and attempted identification of them by liquid chromatography-mass spectrometry (LC-MS). The 4T1-conditioned media were condensed by ammonium sulfate and then fractionated by liquid column chromatography. The IFN-γ suppressing activities of the fractions were examined using splenocytes that were isolated from the 4T1 tumor-bearing mouse. The final active fractions were separated by 2D-polyacrylamide electrophoresis (PAGE). The separated proteins were stained and extracted, and then analyzed by LC-MS and MASCOT search. The predicted proteins will be discussed in this report。

  • ボンクレキン酸は解糖系を促進し、低グルコース環境下で細胞死を誘導する

    狩野 有宏、#深見 契弥、新藤 充

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 4T1細胞培養上清中の免疫抑制性因子の探索

    #山下 聖人、#公 婧、新藤 充、狩野 有宏

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 4T1移植担がんマウスの免疫抑制

    狩野 有宏、#山下 聖人、#公 婧、#Moses K Kamita、新藤 充

    第41回日本分子生物学会年会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 解糖系阻害剤2-DGとボンクレキン酸の共刺激による細胞障害性

    #深見契弥、新藤 充、狩野 有宏

    第41回日本分子生物学会年会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • ボンクレキン酸によるがん細胞選択的細胞障害性の解析

    狩野有宏,#深見契弥,#Kamita Moses,#岩崎琢磨,岩田隆幸,新藤充

    第60回天然有機化合物討論会  2018.9 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  • Role of M-CSF expressed from 4T1 tumor cells in immune activation International conference

    #Jing Gong, #Moses Kamita, Mitsuru Shindo, Arihiro Kano

    2018 IMCE International Symposium  2018.3 

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    Event date: 2018.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • M-CSFによる担がんマウス脾細胞のIFN-γ分泌抑制

    #公 せい、#Kamita Moses、新藤 充、狩野 有宏

    2017年 生命科学系学会合同年次大会(ConBio2017)(第40回日本分子生物学会年会、第90回日本生化学会)  2017.12 

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    Event date: 2017.12

    Language:English  

    Venue:神戸   Country:Japan  

  • ボンクレキン酸によるがん細胞選択的細胞障害性の誘導とその発症機序

    狩野 有宏、#Moses Kamita、#岩崎 琢磨、新藤 充

    2017年 生命科学系学会合同年次大会(ConBio2017)(第40回日本分子生物学会年会、第90回日本生化学会)  2017.12 

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    Event date: 2017.12

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • ボンクレキン酸によるがん細胞障害メカニズムの解析

    狩野有宏

    2017 年度 人・環境と物質をつなぐイノベーション創出ダイナミックアライアンスG3 分科会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • Bongkrekic Acid Facilitates Glycolysis in Cultured Cells Resulting from Mitochondrial Dysfunction International conference

    Arihiro KANO, Moses KAMITA, Takuma IWASAKI, Mitsuru SHINDO

    International Symposium on Materials for Chemistry and Engineering (IMCE 2017)  2017.2 

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    Event date: 2017.2

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 乳がん細胞4T1 が分泌する免疫抑制因子の解析

    藤田 龍郎, Moses Kamita, 新藤 充, 狩野 有宏

    第39回日本分子生物学会年会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

    免疫システムは、がん化した細胞を認識し排除する一方、がん細胞は様々な手段でその監視から逃れていると考えられている。本研究室では、マウス乳がん細胞4T1 を移植したマウスから摘出した脾臓細胞のIFN-γ産生が、4T1 培養上清によって抑制されることを見いだした。これは4T1 が分泌する何らかの液性因子によって免疫が抑制される現象と考えられる。本研究は、4T1 から分泌されるIFN-γ産生抑制因子の同定、及び、それによる免疫抑制メカニズムを解明することを目的とした。4T1 培養上清は、クロマトグラフィーで分画し、IFN-γ産生抑制活性を評価した。そして活性分画の質量分析により、顆粒球コロニー刺激因子(G-CSF)とマクロファージコロニー刺激因子(M-CSF)を見いだした。G-CSF は4T1 から多量に分泌され、骨髄由来免疫抑制細胞(MDSC)を誘導して免疫を抑制し、腫瘍の成長を促進することが報告されている。一方、M-CSFの免疫抑制への関与は十分に明らかにされていない。そこでM-CSFにG-CSFと同様なMDSC誘導能が有るかどうかを現在検証している。また4T1 培養上清のIFN-γ産生抑制活性は、血清非存在下では100kDa 限外濾過フィルター通過分画に見られるのに対し、血清存在下では非通過分画に存在することを見いだしている。これはIFN-γ産生抑制因子が血清因子と相互作用したためと推測される。そこで、4T1 培養上清から部分精製したG-CSF、M-CSF で検証した結果、同様に血清存在下で非通過分画に活性が観察された。一方、大腸菌発現G-CSF、M-CSF 組み換えタンパク質は、血清の有無に関わらず通過分画に活性が観察された。このことから4T1 発現G-CSF、M-CSF は翻訳後修飾を受け、血清因子と相互作用しているものと推測された。そこで、G-CSF、M-CSF 組み換えタンパク質をHEK293 細胞で作製し検証したが、予想に反し血清の有無に関わらず通過分画に活性があることを支持する結果となった。現在、4T1 発現G-CSF、M-CSF組み換えタンパク質の作製を行い、この現象を確認するとともに、さらに詳細な解析を実施している。

  • ボンクレキン酸による癌細胞障害機構の解析 ー 糖代謝異常に基づく抗ガン剤開発を念頭に ー

    狩野有宏

    第3回生物作用小分子研究会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Tumor-derived macrophage colony stimulating factor mediates tumor immunosuppression

    2n International Exchange and Innovation Conference on Engineering & Sciences  2016.10 

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    Event date: 2016.10

    Language:English  

    Country:Japan  

  • Immunosuppression by Murine Mammary Carcinoma Cells, mediated by Tumor-Secreted Soluble Factors

    2015.12 

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    Event date: 2015.12

    Language:English  

    Country:Japan  

  • Analysis of Bongkrekic Acid-induced Tumor Cytotoxicity

    2015.12 

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    Event date: 2015.12

    Language:Japanese  

    Country:Japan  

  • 乳がん細胞4T1腫瘍担持マウスの脾臓細胞の解析

    附置研究所間アラインスによるナノとマクロをつなぐ物質・デバイスシテム創製戦略プロジェクト H26 年度アラインス成果報告会  2015.4 

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    Event date: 2015.4

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • Murine mammary carcinoma 4T1 cells secrete soluble factor(s) for specific immunosuppression International conference

    Arihiro Kano

    Japanese Nano-Macro Materials, Devices and System Research Alliance  2014.11 

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    Event date: 2014.11

    Language:English  

    Country:Japan  

  • Formulation of Photofrin® with cationic graft copolymer and tumor delivery International conference

    2013.10 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:台北市   Country:Taiwan, Province of China  

    We have shown that polyethyleneglycol-grafted poly-L-lysine (PLL-g-PEG) exerts
    long lifetime in blood circulation and effective accumulation in a tumor [1]. It is
    thought that PLL-g-PEG is useful as a drug delivery carrier for tumor treatment. In
    this study, we examined the interaction of Photofrin® [2], a photosensitizer used for
    photodynamic therapy to treat tumors, with PLL-g-PEG, and in addition, evaluated
    the photo-induced cytotoxicity, tumor accumulation, photosensitive reaction in skin,
    a major side effect. For this study, PLL-g-PEG, 40 kDa of PLL, 5 kDa of PEG, and 5
    to 40-mol% of the PEG grafting ratio, was prepared and used. Photofrin consists of 2
    to 6 hematoporphyrins, consequently, it is negatively charged due to 4 to 8 carboxyl
    groups. Therefore this carboxylic multimer seemed to form a complex with PLL-g-
    PEG by ionic interaction. The result of gel retardation assay showed that 1 mol/L
    of NaCl did not affect this interaction suggesting that bonding other than static is
    involved. Intravenously injected Photofrin with PLL-g-PEG showed two-fold higher
    accumulation in tumors in mice, and interestingly, photosensitive reaction in skin and
    tails was completely suppressed [3].

  • Complex Formation and Tumor Accumulation of Photofrin® with Cationic Graft Copolymer for Photodynamic Therapy International conference

    2013.3 

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    Event date: 2013.3

    Venue:つくば   Country:Japan  

  • Ureido-derivatized polymers exhibiting UCST-type phase separation behavior under physiological condition International conference

    Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    2012.12 

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    Event date: 2012.12

    Country:Japan  

  • Smart polymers exhibiting UCST-type behavior in aqueous solutions International conference

    Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    2012.12 

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    Event date: 2012.12

    Country:Japan  

  • 肝類洞内皮細胞の分離と免疫機能解析

    宿利沙郁可、嶋田直彦、狩野有宏、丸山厚

    日本バイオマテリアル学会シンポジウム2012  2012.11 

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    Event date: 2012.11

    Venue:仙台   Country:Japan  

  • UCST Behavior of Ureido-derivatized Polymers in Aqueous Solutions International conference

    2012.11 

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    Event date: 2012.11

    Venue:つくば   Country:Japan  

  • PLL-g-PEGによる光線力学療法剤ポルフィマーナトリウムの腫瘍集積性向上

    谷脇勇輝、森山健司、中村いずみ、嶋田直彦、狩野有宏、丸山厚

    日本バイオマテリアル学会シンポジウム2012  2012.11 

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    Event date: 2012.11

    Venue:仙台   Country:Japan  

  • スマートバイオマテリアルとしてのUCST 型温度応答性ウレイド高分子

    嶋田直彦、中山美紀、狩野有宏、丸山厚

    第61回高分子討論会  2012.10 

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    Event date: 2012.10

    Venue:名古屋   Country:Japan  

  • 尿素基を有するカチオン性くし型共重合体の核酸シャペロン活性の評価

    宋 韡、嶋田直彦、狩野有宏、丸山厚

    第61回高分子討論会  2012.9 

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    Event date: 2012.9

    Venue:名古屋   Country:Japan  

  • 免疫機能解析のための肝内皮細胞の分離

    宿利沙郁可、嶋田直彦、狩野有宏、丸山厚

    日本バイオマテリアル学会 第2回九州地区講演会  2012.9 

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    Event date: 2012.9

    Venue:福岡   Country:Japan  

  • カチオン性くし型共重合体による膜融合ペプチドの二次構造と機能制御

    木下裕貴、嶋田直彦、狩野有宏、丸山厚

    第61回高分子討論会  2012.9 

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    Event date: 2012.9

    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • カチオン性くし型上重合体とアニオン性化合物ヲ用いた生体膜機能制御

    廣濱佳那子、嶋田直彦、丸山厚

    第61回高分子討論会  2012.9 

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    Event date: 2012.9

    Venue:名古屋   Country:Japan  

  • カチオン性グラフト高分子による光線力学療法剤フォトフリン®のデリバリー Invited

    狩野有宏

    日本バイオマテリアル学会 第2回九州地区講演会  2012.9 

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    Event date: 2012.9

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 尿素基を有するカチオン性くし型共重合体の核酸シャペロン活性の評価

    宋 韡、嶋田直彦、狩野有宏、丸山厚

    日本バイオマテリアル学会 第2回九州地区講演会  2012.9 

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    Event date: 2012.9

    Venue:福岡   Country:Japan  

  • カチオン性くし型共重合体による膜融合ペプチドの二次構造と機能制御

    木下裕貴、嶋田直彦、狩野有宏、丸山厚

    日本バイオマテリアル学会 第2回九州地区講演会  2012.9 

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    Event date: 2012.9

    Venue:福岡   Country:Japan  

  • PLL-g-PEG 共重合体を用いた光線力学療法剤送達の検討

    谷脇勇輝、森山健司、中村いずみ、嶋田直彦、狩野有宏、丸山厚

    日本バイオマテリアル学会 第2回九州地区講演会  2012.9 

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    Event date: 2012.9

    Venue:福岡   Country:Japan  

  • カチオン性くし型共重合体によるフォトフリン®の腫瘍集積性 Invited

    狩野有宏

    第12回遺伝子・デリバリー研究会夏期セミナー  2012.7 

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    Event date: 2012.7

    Presentation type:Oral presentation (general)  

    Venue:北九州市   Country:Japan  

  • カチオン性くし型共重合体によるフォトフリンの腫瘍集積性

    谷脇勇輝、森山健司、中村いずみ、嶋田直彦、狩野有宏、丸山厚

    第28回日本DDS学会学術集会  2012.7 

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    Event date: 2012.7

    Venue:札幌   Country:Japan  

  • バイオマテリアルとしての応用を目指したUCST型挙動を示すウレイド高分子の設計

    嶋田直彦、中山美紀、狩野有宏、丸山厚

    第41 回医用高分子シンポジウム  2012.6 

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    Event date: 2012.6

    Venue:東京   Country:Japan  

  • Effects of Sulfation of Hyaluronic Acid on Recognition of Liver Sinusoidal Endothelial Cells International conference

    Arihiro Kano, Ryota Hamano, Akira Teramoto, Naohiko Shimada, Koji Abe, Atsushi Maruyama

    9th World Biomaterials Congress  2012.6 

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    Event date: 2012.6

    Presentation type:Oral presentation (general)  

    Country:China  

  • α-Amino Acid-derived Polycations as pH-sensitive Gene Carriers International conference

    2012.6 

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    Event date: 2012.6

    Presentation type:Oral presentation (general)  

    Venue:成都   Country:China  

  • ウレイド高分子の生理的条件下における相転移挙動

    嶋田直彦、中山美紀、狩野有宏、丸山厚

    第3回統合物質シンポジウム  2012.6 

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    Event date: 2012.6

    Venue:福岡   Country:Japan  

  • UREIDO-POLYMERS EXHIBITING UCST-TYPE PHASE SEPARATION BEHAVIOR UNDER PHYSIOLOGICALLY RELEVANT CONDITION International conference

    Naohiko Shimada, Haruka Ino, Kenji Maie, Miki Nakayama, Arihiro Kano, and Atsushi Maruyama

    243rd ACS National Meeting  2012.3 

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    Event date: 2012.3

    Country:United States  

  • 生理的条件下においてUCST型挙動を示すウレイド高分子

    嶋田直彦、狩野有宏、丸山厚

    ナノメディシン分子科学」 第2回全体会議・シンポジウム  2012.3 

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    Event date: 2012.3

    Venue:京都   Country:Japan  

  • ポリ(L-リシン)-グラフト-ポリエチレングリコール共重合体によるポルフィマーナトリウムの腫瘍デリバリー

    狩野有宏、谷脇勇輝、中村いずみ、森山健司、嶋田直彦、丸山厚

    ナノメディシン分子科学」 第2回全体会議・シンポジウム  2012.3 

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    Event date: 2012.3

    Venue:京都   Country:Japan  

  • Tumor-targeted Drug Delivery System for Photodynamic Therapy Using PLL-g-PEG International conference

    Yuki Taniwaki, Kenji Moriyama, Izumi Nakamura, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Korea-Japan Joint Symposium Recent Trends of Polymeric and Selfassembling Materials and their Application to Biotechnology  2012.2 

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    Event date: 2012.2

    Country:Japan  

  • 生理的条件下で作用する高温溶解型高分子 -バイオマテリアルへの応用を目指した感温性高分子の設計-

    嶋田直彦

    九州大学 新技術説明会  2012.1 

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    Event date: 2012.1

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Ureido-derivatized polymers exhibit UCST-type phase transition behavior under physiologically relevant conditions

    Naohiko Shimada

    GCOE satellite symposium on nanobioscience, nanobiotechnology and nanomedicine  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • Complex formation and tumor accumulation of porfirmer with PLL-g-PEG copolymer for photodynamic therapy Invited International conference

    Arihiro Kano, Yuki Taniwaki, Izumi Nakamura, Naohiko Shimada, Atsushi Maruyama

    the 41th anniversary of the Korean Society of Pharmaceutical Sciences and Technology  2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Elucidation of activation mechanism of cationic comb-type copolymers toward DNA strand exchange reaction

    Noboru Yamaguchi, Naohiko Shimada, Arihiro Kano, Aya Shintani, Atsushi Maruyama

    The 38th International Symposium on Nucleic Acid Chemistry  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • pH-SENSITIVE POLYCATIONS BASED ON ALPHA-AMINO ACID FOR GENE CARRIERS

    Takuya Wada, Arihiro Kano, Naohiko Shimada, Atsushi Maruyama

    The 38th International Symposium on Nucleic Acid Chemistry  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • ウレイド基を有する高分子の生理的条件下における相転移挙動

    嶋田直彦、中山美紀、狩野有宏、丸山厚

    第2回統合物質シンポジウム  2011.11 

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    Event date: 2011.11

    Venue:名古屋   Country:Japan  

  • Ureido polymers Showing UCST-type Behavior under Physiological Conditions International conference

    Naohiko Shimada, Miki Nakayama, Arihiro Kano, Atsushi Maruyama

    Pusan-Gyeongnam/Kyushu-Seibu Joint Symposium On High Polymers (15th) and Fibers (13th)  2011.10 

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    Event date: 2011.10

    Country:Korea, Republic of  

  • カチオン性くし型共重合体によるDNA鎖交換反応の機構解析

    山口登、嶋田直彦、狩野有宏、新谷彩、丸山厚

    第60回高分子討論会  2011.9 

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    Event date: 2011.9

    Venue:岡山   Country:Japan  

  • フローストレッチング法によるポリカチオン/DNA複合体の解析

    尊田尚孝、平野昌典、本田遼、嶋田直彦、狩野有宏、木戸秋悟、真栄城正寿、宮崎真佐也、丸山厚

    第60回高分子討論会  2011.9 

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    Event date: 2011.9

    Venue:岡山   Country:Japan  

  • ウレイド基を側鎖にもつ高分子の生理的条件下におけるUCST挙動

    嶋田直彦・中山美紀・狩野有宏・丸山厚

    第60回高分子討論会  2011.9 

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    Event date: 2011.9

    Venue:岡山   Country:Japan  

  • カチオン性くし型共重合体を用いた光線力学療法剤送達の検討

    谷脇勇輝、森山健司、中村いずみ、嶋田直彦、狩野有宏、丸山厚

    遺伝子・デリバリー研究会 第11回夏期セミナー  2011.8 

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    Event date: 2011.8

    Venue:高知   Country:Japan  

  • フローストレッチング法を利用したポリカチオン-DNA相互作用の解析

    尊田尚孝、平野昌典、本田遼、真栄城正寿、宮崎真佐也、嶋田直彦、狩野有宏、木戸秋悟、丸山厚

    第21回バイオ・高分子シンポジウム  2011.7 

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    Event date: 2011.7

    Venue:大阪   Country:Japan  

  • ウレイド基を有した高分子の生理的条件下におけるUCST挙動

    嶋田直彦・中山美紀・狩野有宏・丸山厚

    第40回医用高分子シンポジウム  2011.7 

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    Event date: 2011.7

    Venue:大阪   Country:Japan  

  • Cationic Comb-Type Copolymers Act as G-quadruplex Annealer International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Third international meeting on G-quadruplex and G-assembly  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Italy  

  • Design of Cationic Graft Copolymers as DNA B-Z Transition Inducer International conference

    Naohiko Shimada

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • Preparation and single-molecular observation of long poly(dG)-poly(dC) International conference

    Noboru Yamaguchi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • Annealing Activity of Cationic Comb-Type Copolymers for DNA assemblies International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • Flow-stretching Assay to Observe Polycation-DNA Interactions International conference

    Naotaka Sonda, Masanori Hirano, Ryo Honda, Masatoshi Maeki, Masaya Miyazaki, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, Atsushi Maruyama

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • pH-Sensitive Polycations Having Alpha-amino Acid as Pendant Groups for Gene Carriers International conference

    Takuya Wada, Arihiro Kano, Naohiko Shimada, Atsushi Maruyama

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • Activation of DNA Strand Exchange Reaction by Novel Cationic Comb-type Copolymers International conference

    Wei Song, Haruka Ino, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • Tumor-targeted Drug Delivery System for Photodynamic Therapy Using PLL-g-PEG International conference

    Yuki Taniwaki, Kenji Moriyama, Izumi Nakamura, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • Preparation of Cellulose/Chitin Composite Films Using Ionic Liquid International conference

    Kanako Hirohama, Shozaburo Mine, Kazuya Yamamoto, Jun-ichi Kadokawa

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • Soluble Inter Polyelectrolyte Complex for DNA and Peptide Chaproning Invited International conference

    Atsushi Maruyama

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Presentation type:Oral presentation (invited, special)  

    Country:China  

  • Complexation of Medical Hydrogels Composed of Synthetic Polymers International conference

    Arihiro Kano

    The 10th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Symposium on Biomaterials 2011  2011.5 

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    Event date: 2011.5 - 2011.6

    Country:China  

  • ウレイド基を有する高分子の官能基依存的な水中UCST 挙動

    嶋田直彦、中山美紀、狩野有宏、丸山厚

    第61回高分子学会年次大会  2012.5 

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    Event date: 2011.5

    Venue:横浜   Country:Japan  

  • 尿素基を有するカチオン性くし型共重合体の核酸シャペロン活性の評価

    宋 韡、嶋田直彦、狩野有宏、丸山厚

    第61回高分子学会年次大会  2012.5 

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    Event date: 2011.5

    Venue:横浜   Country:Japan  

  • Cationic Comb-Type Copolymers for Intermolecular G-quadruplex DNA

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    2011.5 

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    Event date: 2011.5

    Country:Japan  

  • α-アミノ酸修飾ポリカチオンの遺伝子キャリアとしての性質

    和田拓也、嶋田直彦、狩野有宏、丸山厚

    高分子学会年次大会  2011.5 

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    Event date: 2011.5

    Venue:大阪   Country:Japan  

  • カルバミル化ポリアリルアミンの水系UCST挙動とその官能基依存性

    嶋田直彦・中山美紀・狩野有宏・丸山厚

    高分子学会年次大会  2011.5 

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    Event date: 2011.5

    Venue:大阪   Country:Japan  

  • カチオン性くし型共重合体によるDNA鎖交換活性化の機構解析

    山口登、嶋田直彦、狩野有宏、新谷彩、丸山厚

    高分子学会年次大会  2011.5 

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    Event date: 2011.5

    Venue:大阪   Country:Japan  

  • Flow-stretching Assay to Observe Polycation-DNA Interactions

    Naotaka Sonda, Masanori Hirano, Ryo Honda, Masatoshi Maeki, Masaya Miyazaki, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, Atsushi Maruyama

    2011.5 

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    Event date: 2011.5

    Country:Japan  

  • Effects of sulfation of hyaluronan for recognition by liver sinusoidal endothelial cells International conference

    Arihiro Kano, Ryota Hamano, Akira Teramoto, Koji Abe, Atsushi Maruyama

    ICBS2011  2011.3 

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    Event date: 2011.3

    Country:Japan  

  • Poly(allylamine) derivatives exhibiting UCST behavior under physiological conditions International conference

    Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

    ICBS2011  2011.3 

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    Event date: 2011.3

    Country:Japan  

  • カチオン性共重合体とポルフィマーナトリウムの複合体形成と腫瘍集積性

    狩野有宏,谷脇勇輝、森山健司、中村いずみ、嶋田直彦、丸山厚

    附置研究所間アライアンス  2011.3 

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    Event date: 2011.3

    Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • DNA/polycation interactions elucidated by DNA flow-stretching assay at single molecular level International conference

    Naotaka Sonda, Masanori Hirano, Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

    15th International Symposium on Recent Advances in Drug Delivery Systems  2011.2 

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    Event date: 2011.2

    Country:United States  

  • Preparation and single-molecular observation of long poly(dG)-poly(dC) International conference

    Noboru Yamaguchi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    15th International Symposium on Recent Advances in Drug Delivery Systems  2011.2 

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    Event date: 2011.2

    Country:United States  

  • B-Z DNA transition induced by cationic comb-type copolymers International conference

    Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Pacifichem 2010  2010.12 

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    Event date: 2010.12

    Country:United States  

  • カルバミル基を導入したポリカチオン性くし型共重合体の合成とDNAとの相互作用解析

    猪野陽佳、嶋田直彦、狩野有宏、丸山厚

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Venue:広島   Country:Japan  

  • 硫酸化ヒアルロン酸の肝類洞内皮細胞による認識特性

    狩野有宏・濱野僚太・嶋田直彦・寺本彰・ 阿部康次・丸山厚

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Venue:広島   Country:Japan  

  • α-アミノ酸のpH感受性に着目した遺伝子キャリア設計

    和田拓也、嶋田直彦、狩野有宏、丸山厚

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Venue:広島   Country:Japan  

  • PLL-g-PEG共重合体と光線力学療法剤の複合化と腫瘍集積性

    谷脇勇輝、森山健司、中村いずみ、嶋田直彦、狩野有宏、丸山厚

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Venue:広島   Country:Japan  

  • フローストレッチング法によるカチオン性共重合体/DNAの相互作用解析

    尊田尚孝、平野昌典、嶋田直彦、狩野有宏、丸山厚

    第32回日本バイオマテリアル学会大会  2010.11 

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    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Venue:広島   Country:Japan  

  • DNA ANALYSIS BY POLYCATION-ACCELERATED STRAND EXCHANGE REACTION: DESIGN OF A NOVEL DOUBLE STRANDED DNA PROBE International conference

    Riki Kajiyama, Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

    The 37th International Symposium on Nucleic Acids Chemistry 2010  2010.11 

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    Event date: 2010.11

    Country:Japan  

  • Cationic Comb-Type Copolymer Has Annealer Avtivity for Intermolecular G-quadruple DNA International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi maruyama

    The 37th International Symposium on Nucleic Acids Chemistry 2010  2010.11 

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    Event date: 2010.11

    Country:Japan  

  • DNA-Flow stretching assay to observe DNA/Polycation interactions International conference

    Naotaka Sonda, Masanori Hirano, Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

    The 37th International Symposium on Nucleic Acids Chemistry 2010  2010.11 

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    Event date: 2010.11

    Country:Japan  

  • Complex Formation and Tumor Accumulation of Porfimer Sodium With PLL-G-PEG Copolymer for Photodynamic Therapy International conference

    Arihiro Kano, Yuuki Taniwaki, Takeshi Yamano, Izumi Nakamura, Naohiko Shimada, Atsushi Maruyama

    2010 International Symposium of Materials on Regenerative Medicine  2010.11 

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    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • Complex formation and tumor accumulation of porfimer sodium with cationic copolymer for photodyanamic therapy Invited International conference

    Arihiro Kano

    2010.10 

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    Event date: 2010.10

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • カチオン性くし型共重合体による膜融合ペプチドのシャペロニング

    徳永修一、嶋田直彦、狩野有宏、丸山厚

    第59回高分子討論会  2010.9 

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    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • αアミノ酸のpH応答性に着目した遺伝子キャリア設計

    和田拓也、嶋田直彦、狩野有宏、丸山厚

    第59回高分子討論会  2010.9 

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    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • フローストレッチング法を利用したポリカチオン-DNA間相互作用解析

    尊田尚孝、平野昌典、嶋田直彦、狩野有宏、丸山厚

    第59回高分子討論会  2010.9 

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    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • UCST挙動を示すポリアリルアミン誘導体

    嶋田直彦、狩野有宏、丸山厚

    第59回高分子討論会  2010.9 

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    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • ホ?リ(L-リシン)-ク?ラフト-ホ?リエチレンク?リコール共重合体(PLL-g-PEG)の光線力学療法剤ホ?ルフィマーナトリウムとの相互作用と腫瘍テ?リハ?リー

    狩野有宏、中村いす?み、森山健司、嶋田直彦、丸山厚

    第59回高分子討論会  2010.9 

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    Event date: 2010.9

    Venue:札幌   Country:Japan  

  • 生理的条件下で高温溶解相転移を示すポリアリルアミン誘導体

    嶋田直彦、狩野有宏、丸山厚

    第39回医用高分子シンポジウム  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 水溶性グラフト高分子の腫瘍集積性とドラッグデリバリー Invited

    狩野有宏

    九州地区高分子若手研究会・夏の講演会  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  • Suppression of T-cell activation by the conditioned medium of cancer cells International conference

    Miki Sakai

    The 2nd Young Scientist Exchange Symposium for A3 Foresight Program of Gene Therapy  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Synthesis of pH-sensitive polycation having alpha-amino acid for gene delivery International conference

    Takuya Wada

    The 2nd Young Scientist Exchange Symposium for A3 Foresight Program of Gene Therapy  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Application of new fluorescent molecules to biosensing International conference

    Noboru Yamaguchi

    The 2nd Young Scientist Exchange Symposium for A3 Foresight Program of Gene Therapy  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Polycation comb-type copolymer/DNA interactions observed by single molecule spectroscopy International conference

    Naotaka Sonda

    The 2nd Young Scientist Exchange Symposium for A3 Foresight Program of Gene Therapy  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Analysis of the Interaction of Poly(ethylene glycol)-grafted Poly-L-lysine in Various Grafting Ratio with siRNA or Oligo DNA International conference

    Arihiro Kano, Izumi Nakamura, Naohiko Shimada, Atsushi Maruyama

    The 9th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Workshop on Biomaterials 2010  2010.6 

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    Event date: 2010.6

    Country:China  

  • Cationic Comb-Type Copolymer Acts as a DNA G-Quadruplex Chaperone International conference

    Atsushi Maruyama

    The 9th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Workshop on Biomaterials 2010  2010.6 

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    Event date: 2010.6

    Country:China  

  • Recognition of sulfated hyaluronic acid by liver sinusoidal endothelial cells International conference

    Kano, Arihiro; Hamano, Ryota; Mochiduki, Shinichi; Teramoto, Akira; Abe, Koji; Maruyama, Atsushi

    8th International Conference on Hyaluronan 

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    Event date: 2010.6

    Country:Japan  

  • 高い塩基変異識別能を有する新規二重鎖核酸プローブの設計

    梶山力、嶋田直彦、狩野有宏、丸山厚

    高分子学会年次大会  2010.5 

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    Event date: 2010.5

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 分子間四重鎖DNA形成に対するカチオン性共重合体の核酸シャペロン活性機能

    森山塁、嶋田直彦、狩野有宏、丸山厚

    高分子学会年次大会  2010.5 

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    Event date: 2010.5

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • カチオン性くし型共重合体による膜融合ペプチドの構造と機能制御

    徳永修一、嶋田直彦、狩野有宏、丸山厚

    高分子学会年次大会  2010.5 

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    Event date: 2010.5

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 生理的条件下において上限臨界溶液温度を示すポリアリルアミン誘導体

    嶋田直彦、狩野有宏、丸山厚

    高分子学会年次大会  2010.5 

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    Event date: 2010.5

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • CHAPERONING OF MEMBRANE FUSOGENIC PEPTIDES WITH CATIONIC COMB-TYPE COPOLYMERS International conference

    Shuichi Tokunaga, Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

    Symposium on Biomedical Polymers for Drug Delivery  2010.3 

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    Event date: 2010.3

    Country:United States  

  • PREPARATION OF POLY(ALLYLAMINE) DELIVATIVES EXHIBITING UCST BEHAVIOR UNDER PHYSIOLOGICAL CONDITIONS International conference

    Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

    Symposium on Biomedical Polymers for Drug Delivery  2010.3 

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    Event date: 2010.3

    Country:United States  

  • B-Z DNA transition induced by cationic comb-type copolymers International conference

    Naohiko Shimada, Arihiro Kano and Atsushi Maruyama

    2010.1 

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    Event date: 2010.1

    Country:Japan  

  • カチオン性くし型共重合体による生体分子の二次構造制御

    嶋田直彦

    大学間連携第5回物質合成シンポジウム  2009.11 

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    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 部分二重鎖核酸プローブを使ったハイスループットジェノタイピング

    嶋田直彦、石井智也、中村麻子、狩野有宏、丸山厚

    大学間連携第5回物質合成シンポジウム  2009.11 

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    Event date: 2009.11

    Venue:京都   Country:Japan  

  • Design of cationic graft copolymers as a potential inducer of B-Z transition International conference

    Naohiko Shimada, Arihiro Kano ,Atsushi Maruyama

    The 6th International symposium on Nucleic Acid Chemistry  2009.9 

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    Event date: 2009.9 - 2009.10

    Country:Japan  

  • Novel DNA nanomachines driven by polyelectrolytes as fuels

    Jie Du, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 部分二重鎖プローブおよびカチオン性共重合体を用いたRNA解析

    中村麻子、嶋田直彦、石井智也、村木健太郎、狩野有宏、丸山厚

    第58回高分子討論会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • DNAのB-Z転移を誘起するカチオン性くし型共重合体の設計

    嶋田直彦、狩野有宏、丸山厚

    第58回高分子討論会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • 分子間DNA四重鎖に対するカチオン性共重合体のシャペロン活性評価

    森山塁、嶋田直彦、狩野有宏、丸山厚

    第58回高分子討論会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • 肝類洞内皮細胞の酸性多糖に対する認識特性の解析

    浜野僚太、望月慎一、嶋田直彦、狩野有宏、寺本彰、阿部康次、丸山厚

    第58回高分子討論会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • 分子間力測定によるカチオン性くし型共重合体‐核酸間相互作用の解析

    平野昌典、嶋田直彦、狩野有宏、木戸秋悟、丸山厚

    第58回高分子討論会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • DNA部分二重鎖プローブを用いた一塩基多型のハイスループット検出

    石井熬q也、村木煬酎セ郎、嶋田熬シ彦、狩野燉L宏、西田燗゛央、徳永熄沁m、丸山

    第58回高分子討論会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • カチオン性くし型共重合体と酸性ペプチドの相互作用解析

    徳永修一、嶋田直彦、狩野有宏、丸山 厚

    第58回高分子討論会  2009.9 

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    Event date: 2009.9

    Venue:熊本   Country:Japan  

  • 異なる側鎖を有するカチオン性くし型共重合体の合成

    山元美由紀、嶋田直彦、狩野有宏、丸山厚

    第24回生体機能関連化学シンポジウム若手フォーラム  2009.9 

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    Event date: 2009.9

    Venue:福岡   Country:Japan  

  • 高い塩基変異識別能を持つ新規二重鎖DNAプローブの設計

    梶山力、嶋田直彦、狩野有宏、丸山厚

    第24回生体機能関連化学シンポジウム若手フォーラム  2009.9 

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    Event date: 2009.9

    Venue:福岡   Country:Japan  

  • ドラッグデリバリー担体としてのポリエチレングリコールグラフト共重合体の評価

    森山健司、中村いずみ、狩野有宏、丸山厚

    第24回生体機能関連化学シンポジウム若手フォーラム  2009.9 

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    Event date: 2009.9

    Venue:福岡   Country:Japan  

  • 部分二重鎖プローブおよびカチオン性くし型共重合体を用いたRNA解析

    中村麻子、嶋田 直彦、狩野有宏、丸山厚

    第5回CREST公開シンポジウム  2009.8 

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    Event date: 2009.8

    Venue:東京   Country:Japan  

  • カチオン性くし型共重合体がDNAのB-Z転移に与える影響

    嶋田直彦、狩野有宏、丸山厚

    第5回CREST公開シンポジウム  2009.8 

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    Event date: 2009.8

    Venue:東京   Country:Japan  

  • 高い塩基変異識別能を持つ新規二重鎖DNAプローブの設計

    梶山力、嶋田直彦、狩野有宏、丸山厚

    第5回CREST公開シンポジウム  2009.8 

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    Event date: 2009.8

    Venue:東京   Country:Japan  

  • 部分二重鎖プローブおよびカチオン性共重合体を用いたジェノタイピング

    石井 智也、村木 健太郎、嶋田 直彦、狩野 有宏、西田 奈央、徳永 勝士、丸山 厚

    第5回CREST公開シンポジウム  2009.8 

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    Event date: 2009.8

    Venue:東京   Country:Japan  

  • カチオン性くし型共重合体による両親媒性酸性ペプチドの構造制御

    徳永修一、嶋田直彦、狩野有宏、丸山 厚

    第19回バイオ・高分子シンポジウム  2009.7 

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    Event date: 2009.7

    Venue:東京   Country:Japan  

  • DNA のB-Z 転移に与えるカチオン性くし型共重合体の効果

    嶋田直彦、狩野有宏、丸山厚

    第19回バイオ・高分子シンポジウム  2009.7 

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    Event date: 2009.7

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • siRNAとの相互作用に及ぼすポリリシン側鎖にグラフトしたPEG鎖の影響

    狩野有宏、中村いずみ、山野 剛、嶋田直彦、丸山 厚

    遺伝子・デリバリ−研究会 第9回シンポジウム  2009.7 

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    Event date: 2009.7

    Venue:大阪   Country:Japan  

  • 肝類洞内皮細胞の酸性多糖に対する認識特性の解析

    浜野僚太、望月慎一、嶋田直彦、狩野有宏、寺本彰、阿部康次、丸山厚

    第25回DDS学会学術集会  2009.7 

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    Event date: 2009.7

    Venue:東京   Country:Japan  

  • CHAPERONE ACTIVITY OF CATIONIC COMB-TYPE COPOLYMERS FOR INTERMOLECULAR DNA QUADRUPLEX International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Self-Assembly of Guanosine Derivatives: From Biological Systems to Nanotechnological Applications  2009.6 

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    Event date: 2009.6

    Presentation type:Oral presentation (general)  

    Country:Austria  

  • Novel DNA nanomachines driven by polyelectrolytes as fuels International conference

    Jie Du, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 7th ASIA FORESIGHT SYMPOSIUM ON GENE THERAPY AND BIOMATERIALS  2009.5 

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    Event date: 2009.5

    Country:Korea, Republic of  

  • Synergistic Stabilization of Nucleic Acid Assembly by Nucleic Acid Chemical Modification and Addition of Conb-Type Cationic Copolymers International conference

    Atsushi Maruyama, Takuma Katayama, Hidetaka Torigoe, Satoshi Obika, Takeshi Imanishi

    The 7th ASIA FORESIGHT SYMPOSIUM ON GENE THERAPY AND BIOMATERIALS  2009.5 

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    Event date: 2009.5

    Country:Korea, Republic of  

  • The effect of Grafted PEG side chain on the interaction of poly-L-lysine with siRNA International conference

    Arihiro Kano, Tsuyoshi Yamano, Izumi Nakamura, Naohiko Shimada, Atsushi Maruyama

    The 7th ASIA FORESIGHT SYMPOSIUM ON GENE THERAPY AND BIOMATERIALS  2009.5 

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    Event date: 2009.5

    Country:Korea, Republic of  

  • Effect of cationic Comb Type Copolymer on the B-Z transition International conference

    Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 7th ASIA FORESIGHT SYMPOSIUM ON GENE THERAPY AND BIOMATERIALS  2009.5 

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    Event date: 2009.5

    Country:Korea, Republic of  

  • Novel Analysis for Single Nucleotide Polymorphism Using Cationic Comb-Type Copolymer International conference

    Asako Nakamura, Naohiko Shimada, Kentaro Muraki, Taro Anai, Arihiro Kano ,Atsushi Maruyama

    The 2nd POSTEC/KYUSHU UNIVERSITY GLOVAL=COE joint simposium on polymers and Nanomaterials  2009.2 

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    Event date: 2009.2

    Country:Korea, Republic of  

  • WATER-SOLUBLE POLYMERIC CONJUGATE FOR GENE AND DRUG DELIVERY International conference

    A. Kano, T. Yamano, S. Mochizuki, I. Nakamura, N. Shimada, and A. Maruyama

    14th International Symposium on Recent Advance in Drug Delivery Systems  2009.2 

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    Event date: 2009.2

    Country:United States  

  • Control of intermolecular quadruplex DNA folding by cationic comb-type copolymer International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 2008 Materials Reseach Society Fall Meeting  2008.12 

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    Event date: 2008.12

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Control of association and dissociation of intermolecular quadruplex by cationic comb-type copolymer International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Country:China  

  • Highly faithful DNA hybridization produced by an engineered folding pathway and cationic comb-type copolymers International conference

    Atsushi Maruyama, Kazuya Hirata, Daisuke Ishii, Kentaro Muraki, Tomoya Ishii Naohiko Shimada, Arihiro Kano

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Country:China  

  • Effect of poly(L-lysine)-graft-dextran on the B-Z transition International conference

    Naohiko Shimada, Arihiro Kano, and Atsushi Maruyama

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Country:China  

  • Hydrophilic side chain-graft Poly-L-lysine for gene and drug delivery International conference

    Arihiro Kano, Takeshi Yamano, Izumi Nakamura, Naohiko Shimada, and Atsushi Maruyama

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Country:China  

  • A novel self-complementary DNA nanomachine driven by polyelectrolyte International conference

    Jie Du, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Country:China  

  • Preparation of Cationic Comb-Type Copolymers having High Density of PEG Graft Chains for Gene Carriers International conference

    Miyuki Yamamoto, Sung Won Choi, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Country:China  

  • The evaluation of polyethylene glycol graft copolymer as the drug delivery carrier International conference

    Kenji Moriyama, Takeshi Yamano, Sun Won Choi, Arihiro Kano, Atushi Maruyama

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Country:China  

  • Novel Analysis for Single Nucleotide Polymorphism Using Cationic Comb-Type Copolymer International conference

    Asako Nakamura, Naohiko Shimada, Kentaro Muraki, Taro Anai, Arihiro Kano ,Atsushi Maruyama

    JSPS 6th A3 Symposium  2008.11 

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    Event date: 2008.11

    Country:China  

  • 部分二重鎖DNAプローブを使った新規SNPs検出方法

    嶋田直彦、石井智也、中村麻子、狩野有宏、西田奈央、徳永勝士、丸山厚

    日本DNA多型学会 第17回学術集会  2008.11 

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    Event date: 2008.11 - 2008.1

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 分子直接観察と分子間力測定によるカチオン性くし型共重合体-核酸間相互作用の解析

    平野昌典、嶋田直彦、狩野有宏、木戸秋悟、丸山厚

    日本バイオマテリアル  2008.11 

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    Event date: 2008.11

    Venue:東京   Country:Japan  

  • 肝類洞内皮細胞の酸性多糖に対する認識特性の解析

    浜野僚太、望月慎一、嶋田直彦、狩野有宏、寺本彰、阿部康次、丸山厚

    日本バイオマテリアル  2008.11 

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    Event date: 2008.11

    Venue:東京   Country:Japan  

  • DNA部分二重鎖プローブを用いた一塩基多型検出のハイスループット化

    石井智也、村木健太郎、嶋田直彦、狩野有宏、西田奈央、徳永勝士、丸山厚

    日本バイオマテリアル  2008.11 

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    Event date: 2008.11

    Venue:東京   Country:Japan  

  • ヒアルロン酸グラフト共重合体による核酸デリバリー法の開発とその評価

    城山宗一郎、狩野有宏、望月慎一、嶋田直彦、丸山厚

    日本バイオマテリアル  2008.11 

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    Event date: 2008.11

    Venue:東京   Country:Japan  

  • ポリリシン-g-ポリエチレングリコール共重合体(PLL-g-PEG)の細胞取り込みと動態評価

    芥川礼、山野剛、嶋田直彦、狩野有宏、丸山厚

    日本バイオマテリアル  2008.11 

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    Event date: 2008.11

    Venue:東京   Country:Japan  

  • 部分二重鎖DNAプローブとカチオン性くし型共重合体を利用したハイスループットジェノタイピング

    嶋田直彦、石井智也、狩野有宏、西田奈央、徳永勝士、丸山厚

    第57回高分子討論会  2008.9 

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    Event date: 2008.9

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • ポリリシン-g-ポリエチレングリコール共重合体(PLL-g-PEG)の細胞取り込みと動態評価

    芥川礼、山野剛、嶋田直彦、狩野有宏、丸山厚

    第57回高分子討論会  2008.9 

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    Event date: 2008.9

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • DNAのB-Z転移に与えるカチオン性くし型共重合体の効果

    嶋田直彦、狩野有宏、丸山厚

    第57回高分子討論会  2008.9 

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    Event date: 2008.9

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • WATER-SOLUBLE POLYMERIC CONJUGATE FOR GENE AND DRUG DELIVERY International conference

    Arihiro Kano, Takeshi Yamano, Shinichi Mochizuki, Izumi Nakamura, Naohiko Shimada, and Atsushi Maruyama

    The 2nd CNSI UCLA/G-COE Kyushu University Joint Symposium  2008.9 

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    Event date: 2008.9

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • POLY(L-LYSINE)-GRAFT-DEXTRAN COPOLYMER ACCELERATES DNA HYBRIDIZATION BY TWO ORDERS International conference

    Jie Du, Longliang Wu, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    The 2nd CNSI UCLA/G-COE Kyushu University Joint Symposium  2008.9 

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    Event date: 2008.9

    Country:Japan  

  • Effect of cationic comb-type copolymer on the B- Z transition of poly(dG-dC)・poly(dG-dC) International conference

    2008.9 

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    Event date: 2008.9

    Venue:京都   Country:Japan  

  • Analysis of cationic comb-type copolymers/DNA interaction by the single molecular observation and intermolecular force measurement International conference

    Masanori Hirano, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, Atsushi Maruyama

    Joint Symposium of 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chemistry  2008.9 

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    Event date: 2008.9

    Country:Japan  

  • Polymer brush-stabilized polyplex for a siRNA carrier with long blood circulatory half-life International conference

    Arihiro Kano,Takeshi Yamano, Sun Won Choi, Atsushi Maruyama

    International Conference on Multifunctional Materials and Structures(2008)  2008.7 

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    Event date: 2008.7

    Presentation type:Oral presentation (general)  

    Country:China  

  • PLL-g-PEG共重合体の腫瘍集積性の解析とsiRNAデリバリーへの応用

    狩野有宏、山野剛、丸山厚

    第24回日本DDS学会  2008.6 

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    Event date: 2008.6

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Kinetic Effect of Cationic Comb-type Copolymers on DNA Hybridization International conference

    Atsushi Maruyama, Longliang Wu, Naohiko Shimada, Arihiro Kano

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Analysis of cationic comb-type copolymers/DNA interaction by the single molecular observation and intermolecular force measurement International conference

    Masanori Hirano, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • The analysis of Recognition of glycosaminoglycan by liver sinusoidal endothelial cells International conference

    Ryota Hamano, Shinichi Mochizuki, Naohiko Shimada, Arihiro Kano, Koji Abe, Akira Teramoto, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • High throughput analysis of single nucleotide polymorphisms using partially double-stranded DNA probes International conference

    Tomoya Ishii, Kentaro Muraki, Arihiro Kano, Nao Nishida, Katsushi Tokunaga, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Country:Korea, Republic of  

  • Gene Delivery Using hyaluronan Comb-Type Cationic Copolymer International conference

    Soichiro Shiroyama, Arihiro Kano, Naohisa Fujii, Sinichi Mochiduki, Toshihiro Akaike, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Identification and Cloning of Genes Involved in IFN-g-Induced Apoptosis Using a siRNA Expression Library International conference

    Masashi Akutagawa, Arihiro Kano, Naohiko Shimada, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Role of phosphorylation of ezrin in the membrane localization of NaPi-Iia in the renal proximal tubular cells International conference

    Asako Nakamura, Yutaka Taketani, Ayako Tanimura, Hironori Yamamoto, Ken-ichi Miyamoto, Eigi Takeda

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Effect of cationic comb-type copolymers on the intermolecular DNA quadruplex International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Supramolecular Control of Polyplex Decondensation and Cell Transfection: Efficacy of Amine and Threading Cyclodextrin on Biocleavable Polyrotaxanes International conference

    A. Yamashita, D. Kanda, R. Katoono, N. Yui, A. Kano, A. Maruyama, H. Akita, H. Harashima

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Antigenic protein delivery to liver sinusoidal endothelial cells by conjugation with hyaluronan International conference

    Shinichi Mochiduki, Arihiro kano, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Polymer brush-stabilized polyplex for a siRNA carrier with long blood circulatory half-life International conference

    Arihiro Kano, Naohiko Shimada, Atsushi maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Novel analysis for single nucleotide polymorphism using cationic comb-type copolymers International conference

    Naohiko Shimada, Kentaro Muraki, Taro Anai, Arihiro Kano, Atsushi Maruyama

    JSPS 5th A3 Symposium  2008.6 

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    Event date: 2008.6

    Country:Korea, Republic of  

  • Polymer Brush-Stabilized Polyplex for a siRNA Carrier with Long Circulatory Half-life International conference

    A Maruyama, T Yamano, SW Choi, N Shimada, A Kano

    8th World Biomaterials Congress  2008.5 

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    Event date: 2008.5

    Presentation type:Oral presentation (general)  

    Country:Austria  

  • siRNAキャリアとしてのボトルブラシ型PEG-g-PLLのin vivo評価

    狩野有宏、山吉麻子、山野 剛、平井美和、佐藤あゆみ、高木基樹、嶋本 顕、丸山 厚

    第8回遺伝子・デリバリーシンポジウム  2008.5 

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    Event date: 2008.5

    Venue:大阪   Country:Japan  

  • 肝類洞内皮細胞の酸性多糖に対する認識特性の解析

    浜野僚太、望月慎一、嶋田直彦、狩野有宏、阿部康次、丸山厚

    第6回ナノ学会  2008.5 

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    Event date: 2008.5

    Venue:福岡   Country:Japan  

  • 分子直接観察と分子間力測定によるカチオン性くし型共重合体-核酸間相互作用の解析

    平野昌典、嶋田直彦、狩野有宏、木戸秋悟、丸山厚

    第6回ナノ学会  2008.5 

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    Event date: 2008.5

    Venue:福岡   Country:Japan  

  • Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life International conference

    A. Kano, T. Yamano, S. Choi, A. Maruyama

    1st Asian Biomaterials Congress (1st ABMC)  2007.12 

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    Event date: 2007.12

    Country:Japan  

  • A Novel Genotyping Method Using Partially Double-stranded DNA Probes and Cationic Comb-type Copolymers International conference

    Naohiko Shimada, Kentaro Muraki, Taro Anai, Arihiro Kano and Atsushi Maruyama

    1st Asian Biomaterials Congress (1st ABMC)  2007.12 

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    Event date: 2007.12

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • カチオン性くし型共重合体とリポソームとの相互作用評価

    岩田智喜、望月慎一、狩野有宏、嶋田直彦、丸山厚

    第29回バイオマテリアル学会  2007.11 

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    Event date: 2007.11

    Venue:大阪   Country:Japan  

  • 免疫制御を目指した肝類洞内皮細胞への抗原タンパク質デリバリー

    望月慎一、狩野有宏、嶋田直彦、丸山厚

    第29回バイオマテリアル学会  2007.11 

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    Event date: 2007.11

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • Novel analysis for single nucleotide polymorphism using cationic comb-type copolymers International conference

    Naohiko Shimada, Kentaro Muraki, Taro Anai, Arihiro Kano, and Atsushi Maruyama

    2007.11 

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    Event date: 2007.11

    Country:Japan  

  • Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization International conference

    Longliang Wu, Naohiko Shimada, Arihiro Kano, and Atsushi Maruyama

    2007.11 

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    Event date: 2007.11

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Hyaluronan bioconjugates for targeted delivery to sinusoidal endothelial cells in liver International conference

    Arihiro Kano, Shinichi Mochiduki, Sung Won Choi, and Atsushi Maruyama

    IMRAM-England-IMCE 1st Joint Workshop  2007.10 

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    Event date: 2007.10

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 親水性側鎖によりポリリシンの二次構造転移制御

    森山 塁、佐藤雄一、崔 成源、嶋田直彦、狩野有宏、丸山厚

    第56回高分子討論会  2007.9 

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    Event date: 2007.9

    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • PEG 密生層によるオリゴ核酸ポリプレックスの安定化

    山野剛、山吉麻子、崔成源、嶋田直彦、狩野有宏、丸山厚

    第56回高分子討論会  2007.9 

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    Event date: 2007.9

    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • カチオン性共重合体による部分二重鎖プローブの一塩基変異認識特性の改善

    村木健太郎、穴井太郎、嶋田直彦、狩野有宏、丸山厚

    第56回高分子討論会  2007.9 

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    Event date: 2007.9

    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 一塩基多型(SNPs)認識を目指した部分二重鎖DNAプローブの設計

    嶋田直彦、村木健太郎、穴井太郎、狩野有宏、丸山厚

    CREST第3回公開シンポジウム  2007.8 

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    Event date: 2007.8

    Venue:東京   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型 PEG-g-PLL の in vivo 評価

    狩野有宏、山吉麻子、山野 剛、丸山 厚

    CREST第3回公開シンポジウム  2007.8 

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    Event date: 2007.8

    Venue:東京   Country:Japan  

  • 核酸鎖交換反応を用いたDNA結合性物質の認識

    丸山厚、新谷彩、東条野歩、山吉麻子、狩野有宏

    CREST第3回公開シンポジウム  2007.8 

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    Event date: 2007.8

    Venue:東京   Country:Japan  

  • カチオン性共重合体の一次構造と核酸シャペロン活性の相関

    丸山厚、高田薫、崔成源、山吉麻子、狩野有宏

    CREST第3回公開シンポジウム  2007.8 

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    Event date: 2007.8

    Venue:東京   Country:Japan  

  • ヒアルロン酸くし型共重合体による核酸医薬の細胞特異的送達

    城山宗一郎、狩野有宏、藤井尚久、望月慎一、崔成源、山吉麻子、赤池敏宏、丸山厚

    第23回日本DDS学会  2007.6 

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    Event date: 2007.6

    Venue:熊本   Country:Japan  

  • 一塩基多型(SNPs)認識を目指した部分二重鎖DNAプローブの設計

    村木健太郎、石井大輔、穴井太郎、狩野有宏、山吉麻子、丸山厚

    第56回高分子学会年次大会  2007.5 

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    Event date: 2007.5

    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 核酸ハイブリダイゼーションに対するカチオン性共重合体の速度論的効果

    呉隆亮、狩野有宏、山吉麻子、丸山厚

    第56回高分子学会年次大会  2007.5 

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    Event date: 2007.5

    Venue:京都   Country:Japan  

  • 部分二重鎖プローブを用いた一塩基変異検出における配列依存性の影響

    穴井太郎、石井大輔、村木健太郎、山吉麻子、狩野有宏、丸山厚

    第56回高分子学会年次大会  2007.5 

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    Venue:京都   Country:Japan  

  • PEGブラシによるsiRNAポリプレックスの強化

    山野剛、山吉麻子、崔成源、嶋田直彦、狩野有宏、丸山厚

    遺伝子・デリバリー研究会 第七回シンポジウム  2007.5 

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    Event date: 2007.5

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型PEG-g-PLLのin vivo評価

    狩野有宏、山吉麻子、山野剛、平井美和、佐藤あゆみ、高木基樹、嶋本顕、丸山厚

    遺伝子・デリバリー研究会 第七回シンポジウム  2007.5 

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    Event date: 2007.5

    Venue:東京   Country:Japan  

  • Hyaluronan Bioconjugates for Targeted Delivery to Liver Sinusoidal Endothelial Cells International conference

    Shinichi Mochizuki, Arihiro kano and Atsushi Maruyama

    3rd Symposium of A3 Foresight Program on Gene Delivery  2007.5 

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    Event date: 2007.5

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Korea, Republic of  

  • カチオン性共重合体による分子間DNA四重鎖の形成制御

    森山塁、嶋田直彦、狩野有広、丸山厚

    第57回高分子討論会  2008.9 

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    Venue:大阪   Country:Japan  

  • ヒアルロン酸修飾による肝類洞内皮細胞へのプロテインデリバリー

    望月慎一、狩野有宏、赤池敏宏、丸山厚

    第53回高分子学会年次大会  2004.5 

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    Venue:兵庫   Country:Japan  

  • 生分解性ポリロタキサンの遺伝子導入活性

    大滝(菅谷)祐子、狩野有宏、大谷亨、吉廣淳人、山下敦、赤池敏宏、丸山厚、由井伸彦

    遺伝子・デリバリー研究会 第4回シンポジウム  2004.5 

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    Venue:京都   Country:Japan  

  • ヒアルロン酸を利用した肝類洞内皮細胞へのプロテインターゲティング

    望月慎一・狩野有宏・赤池敏宏・丸山厚

    第20回日本DDS学会  2004.7 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 生分解性ポリロタキサンの遺伝子導入活性

    狩野有宏、菅谷祐子、大谷亨、吉廣淳人、山下厚、赤池敏宏、丸山厚、由井伸彦

    第20回日本DDS学会  2004.7 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Characterization of IFN-gamma-induced apoptosis in SV40-T-immortalized hepatocytes

    Arihiro Kano, Serdar Gursoy, Toshihiro Akaike, Atsushi Maruyama

    2004.10 

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    Characterization of IFN-gamma-induced apoptosis in SV40-T-immortalized hepatocytes.
    Arihiro Kano, Serdar Gursoy, Toshihiro Akaike, Atsushi Maruyama
    The Japanese Biochemical Society

  • Nucleation-synchronized strand displacement for highly sensitive DNA analysis International conference

    KAZUYA HIRATA, YUICHI SATO, KANO ARIHIRO, TOSHIHIRO AKAIKE and ATSUSHI MARUYAMA

    2004.11 

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    Country:Japan  

    Nucleation-synchronized strand displacement for highly sensitive DNA analysis

  • ヒアルロン酸くし型共重合体の細胞特異性の評価

    藤井尚久・崔成源・狩野有宏・赤池敏宏・丸山厚

    第 54 回 高 分 子 年 次 大 会  2005.5 

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    Venue:横浜   Country:Japan  

  • 免疫制御を目指した肝類洞内皮細胞へのタンパク質デリバリー

    望月慎一・狩野有宏・赤池敏宏・丸山厚

    第21回 日本DDS学会  2005.7 

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    Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • Nucleation-Synchronized Strand Exchange Reaction for DNA Mismatches Discrimination International conference

    Kazuya Hirata, Daisuke Ishii, Arihiro Kano, Toshihiro Akaike and Atsushi Maruyama

    The 8th SPSJ International Polymer Conference (IPC2005)  2005.7 

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    Country:Japan  

    Nucleation-Synchronized Strand Exchange Reaction for DNA Mismatches Discrimination

  • インターフェロン-γによる肝細胞障害の解析とsiRNAライブラリーによる遺伝子スクリーニング

    狩野有宏・隈秀和・野沢巌・丸山厚

    CREST第1回公開シンポジウム  2005.8 

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    Venue:東京   Country:Japan  

  • 部分2重鎖核酸プローブによる一塩基変異解析

    平田和也、石井大輔、山吉麻子、狩野有宏、赤池敏宏、丸山厚

    CREST第1回公開シンポジウム  2005.8 

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    Venue:東京   Country:Japan  

  • 血中滞留型siRNAキャリアとしての人工核酸シャペロン

    山吉麻子、佐藤あゆみ、平井美和、高木基樹、Choi, Sung Won、狩野有宏、嶋本顕、丸山厚

    CREST第1回公開シンポジウム  2005.8 

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    Venue:東京   Country:Japan  

  • 人工核酸シャペロンによる4重鎖核酸形成の制御

    牧田尚樹、山吉麻子、狩野有宏、赤池敏宏、丸山厚

    CREST第1回公開シンポジウム  2005.8 

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    Venue:東京   Country:Japan  

  • 部分2重鎖核酸プローブとカチオン性共重合体による迅速変異検出

    平田和也、石井大輔、狩野有宏、赤池敏宏、丸山厚

    第34回医用高分子シンポジウム  2005.8 

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    Venue:東京   Country:Japan  

  • Discrimination of single nucleotide polymorphisms by strand exchange assay using partially double-stranded probes International conference

    Kazuya Hirata, Daisuke Ishii, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike and Atsushi Maruyama

    2005.9 

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    Country:Japan  

    Discrimination of single nucleotide polymorphisms by strand exchange assay using partially double-stranded probes

  • Modulation of highly ordered structures of human telomeric sequence by cationic copolymers. International conference

    Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike, Atsushi Maruyama

    2005.9 

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    Country:Japan  

  • 鎖長の異なる部分二重鎖プローブによる一塩基変異認識

    石井大輔・平田和也・狩野有宏・山吉麻子・丸山厚

    第 54 回 高 分 子 討論会  2005.9 

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    Venue:山形   Country:Japan  

  • 肝類洞内皮細胞によるヒアルロン酸修飾タンパクの認識特性

    望月慎一、狩野有宏、山吉麻子、丸山厚

    第 54 回 高 分 子 討論会  2005.9 

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    Venue:山形   Country:Japan  

  • 一次構造の異なるポリカチオン共重合体の核酸シャペロン機能

    高田薫・崔成源・牧田尚樹・山吉麻子・狩野有宏・赤池敏宏・丸山厚

    第54回高分子討論会  2005.9 

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    Venue:山形   Country:Japan  

  • 異なるカチオン基を有するくし型共重合体の核酸シャペロン活性

    崔成源、狩野有宏、山吉麻子、丸山厚

    第27回日本バイオマテリアル学会  2005.11 

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    Venue:京都   Country:Japan  

  • くし型ポリカチオンのRNAに対する核酸シャペロン効果

    高田薫、崔成源、牧田尚樹、山吉麻子、狩野有宏、丸山厚

    第27回日本バイオマテリアル学会  2005.11 

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    Venue:京都   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型カチオン性高分子 核酸との相互作用におけるPEGブラシの影響

    山吉麻子、山野 剛、崔 成源、狩野有宏、平井美和、佐藤あゆみ、高木基樹、島本 顕、丸山 厚

    第15回アンチセンスシンポジウム  2005.11 

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    Venue:桐生   Country:Japan  

  • DNA 鎖交換反応を用いた一塩基変異認識

    石井大輔、平田和也、山吉麻子、狩野有宏、丸山厚

    第27回日本バイオマテリアル学会  2005.11 

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    Venue:京都   Country:Japan  

  • ODNキャリアーとしてのヒアルロン酸くし型共重合体の評価

    藤井尚久、崔 成源、狩野有宏、赤池敏宏、丸山 厚

    第15回アンチセンスシンポジウム  2005.11 

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    Venue:群馬   Country:Japan  

  • 核酸キャリアーとしてのヒアルロン酸くし型共重合体の細胞特異性

    狩野有宏、藤井尚久、崔 成源、丸山 厚

    第37回九大生体材料・力学研究会  2006.3 

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    Venue:福岡   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型カチオン性高分子

    山吉麻子、山野 剛、崔 成源、狩野有宏、平井美和、佐藤あゆみ、高木基樹、島本 顕、丸山 厚

    第6回遺伝子デリバリー研究会 シンポジウム  2006.5 

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    Venue:福岡   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型カチオン性共重合体

    山野剛、山吉麻子、崔 成源、狩野有宏、平井美和、佐藤あゆみ、高木基樹、島本 顕、丸山 厚

    第6回遺伝子デリバリー研究会 シンポジウム  2006.5 

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    Venue:福岡   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型カチオン性高分子

    山吉麻子、山野 剛、崔 成源、狩野有宏、平井美和、佐藤あゆみ、高木基樹、島本 顕、丸山 厚

    第22回日本DDS学会  2006.7 

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    Venue:東京   Country:Japan  

  • オリゴ核酸キャリアーとしてのヒアルロン酸くし型共重合体の評価

    山吉麻子、藤井尚久、崔成源、狩野有宏、赤池敏宏、丸山厚

    第22回日本DDS学会  2006.7 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Targeted DNA Delivery to Sinusoidal Endothelial Cells of Liver Using Cationic Comb-Type Copolymers Having Hyaluronic Acids International conference

    Atsushi Maruyama, Naohisa Fujii, Shinichi Mochiduki, Sung Won Choi, Asako Yamayoshi, Arihiro Kano, Yoshiyuki Takei, Nobuhiro Sato, Toshihiro Akaike

    33rd Annual Meeting & Exposition of the Controlled Release Society  2006.7 

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    Presentation type:Oral presentation (general)  

    Country:Austria  

  • Bottle Brush-Type Copolymers Stabilize Small Interfering RNA in vitro and in vivo International conference

    Arihiro Kano, Asako Yamayoshi, Takeshi Yamano, Sung Won Choi, Motoki Takagi, Ayumi Sato, Miwa Hirai, Akira Shimamoto, Atsushi Maruyama

    33rd Annual Meeting & Exposition of the Controlled Release Society  2006.7 

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    Presentation type:Oral presentation (general)  

    Country:Austria  

  • 核酸親和性を制御したカチオン性高分子の核酸シャペロン活性

    高田薫、崔成源、山吉麻子、狩野有宏、丸山厚

    CREST第2回公開シンポジウム  2006.8 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型カチオン性高分子

    山吉麻子、山野 剛、崔 成源、狩野有宏、平井美和、佐藤あゆみ、高木基樹、島本 顕、丸山 厚

    CREST第2回公開シンポジウム  2006.8 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 部分二重鎖プローブによる一塩基変異解析〜プローブ構造とシャペロン高分子の影響

    狩野有宏、石井大輔、村木健太郎、山吉麻子、丸山厚

    CREST第2回公開シンポジウム  2006.8 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 部分二重鎖プローブによる一塩基変異解析〜変異識別の熱力学的考察

    石井大輔、村木健太郎、狩野有宏、山吉麻子、丸山厚

    CREST第2回公開シンポジウム  2006.8 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 核酸親和性を制御したカチオン性共重合体の核酸シャペロン活性

    高田薫、崔成源、山吉麻子、狩野有宏、丸山厚

    第16回バイオ・高分子シンポジウム  2006.8 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型カチオン性高分子

    山吉麻子、山野 剛、崔 成源、狩野有宏、平井美和、佐藤あゆみ、高木基樹、島本 顕、丸山 厚

    第35回医用高分子シンポジウム  2006.8 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • siRNAとの結合性を強化したボトルブラシ型カチオン性共重合体—PEGブラシ鎖密度の影響

    山野剛、崔成源、山吉麻子、狩野有宏、丸山厚

    第55回高分子討論会  2006.9 

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    Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  • 人工核酸シャペロンを利用したDNAナノマシンの制御

    崔成源、牧田直樹、狩野有宏、山吉麻子、赤池敏宏、丸山厚

    第55回高分子討論会  2006.9 

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    Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  • 人工核酸シャペロンを利用したDNAナノマシンの制御

    新谷彩、東條野歩、山吉麻子、狩野有宏、丸山厚

    第55回高分子討論会  2006.9 

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    Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  • Targeted DNA Delivery to Sinusoidal Endothelial Cells of Liver Using Cationic Comb-Type Copolymers Having Hyaluronic Acids International conference

    Arihiro Kano, Naohisa Fujii, Shinichi Mochiduki, Sung Won Choi, Asako Yamayoshi, Yoshiyuki Takei, Nobuhiro Sato, Toshihiro Akaike, and Atsushi Maruyama

    IUPAC International Symposium on Advanced Polymers for Emerging Technologies  2006.10 

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    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Nucleic acid chaperoning activity of cationic copolymers with different primary structures International conference

    Kaoru Takada, Sung Won Choi, Arihiro Kano, Asako Yamayoshi, Atsushi Maruyama

    IUPAC International Symposium on Advanced Polymers for Emerging Technologies  2006.10 

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    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Prolonged blood circulation of small interfering RNA by bottlebrush-type copolymers International conference

    Asako Yamayoshi, Arihiro Kano, Takeshi Yamano, Sung Won Choi, Motoki Takagi, Ayumi Sato, Miwa Hirai, Akira Shimamoto, Atsushi Maruyama

    IUPAC International Symposium on Advanced Polymers for Emerging Technologies  2006.10 

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    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • The influence of DNA binding molecules on the DNA strand exchange reaction International conference

    Aya Shintani, Nobu Tojyo, Arihiro Kano, Asako Yamayoshi, Atsushi Maruyama

    IUPAC International Symposium on Advanced Polymers for Emerging Technologies  2006.10 

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    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Hyaluronan bioconjugates for targeted delivery to liver endothelial cells International conference

    Shinichi Mochizuki, Arihiro kano, Asako Yamayoshi, Atsushi Maruyama

    IUPAC International Symposium on Advanced Polymers for Emerging Technologies  2006.10 

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    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Cationic Comb-type Copolymers to Boost DNA Nanomachine International conference

    Sung Won Choi, Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike, Atsushi Maruyama

    IUPAC International Symposium on Advanced Polymers for Emerging Technologies  2006.10 

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    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Structural effect of cationic copolymers on nucleic acid-chaperoning activity

    Kaoru Takada, Sung Won Choi, Arihiro Kano, Asako Yamayoshi, Atsushi Maruyama

    2006.11 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Single-base mismatch recognition using partially double-stranded probes having various lengths

    Daisuke Ishii, Kentaro Muraki, Arihiro Kano, Asako Yamayoshi, Atsushi Maruyama

    2006.11 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • カチオン基の異なるくし型共重合体の核酸シャペロン活性

    崔成源、狩野有宏、山吉麻子、丸山厚

    第28回日本バイオマテリアル学会  2006.11 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • siRNAキャリアとしてのボトルブラシ型カチオン性高分子

    山吉麻子、山野 剛、崔 成源、狩野有宏、平井美和、佐藤あゆみ、高木基樹、島本 顕、丸山 厚

    第36回アンチセンスシンポジウム  2006.11 

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    Venue:京都   Country:Japan  

  • 免疫寛容の誘導を目指した肝類洞内皮細胞への抗原タンパク質デリバリー

    望月慎一、狩野有宏、山吉麻子、丸山厚

    第28回日本バイオマテリアル学会  2006.11 

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    Venue:東京   Country:Japan  

  • Hyaluronan bioconjugates for targeted delivery to sinusoidal endothelial cells in liver Invited International conference

    Arihiro Kano, Atsushi Maruyama

    The 36th Annual Meeting of the Korean Society of Pharmaceutical Sciences and Technology  2006.11 

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    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • カチオン基の異なるくし型共重合体の核酸シャペロン活性

    山吉麻子、高田薫、崔 成源、狩野有宏、二木史朗、丸山 厚

    2007.1 

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    Venue:京都・宇治   Country:Japan  

  • DNA nanomachine responses improved by cationic comb-type copolymer International conference

    Sung Won Choi, Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike, Atsushi Maruyama

    The 13th International Symposium on Recent Advances in Drug Delivery Systems  2007.2 

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    Country:United States  

  • 核酸鎖交換反応を用いたDNA結合性物質の認識

    新谷彩、東條野歩、山吉麻子、狩野有宏、丸山厚

    第56回高分子学会年次大会  2007.5 

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    Venue:京都   Country:Japan  

  • カチオン性共重合体の一次構造と核酸シャペロン活性の相関

    高田薫、崔成源、山吉麻子、狩野有宏、丸山厚

    第56回高分子学会年次大会  2007.5 

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    Venue:京都   Country:Japan  

  • 肝類洞内皮細胞への薬物デリバリーを目指したヒアルロン酸修飾リポソームの調製

    岩田智喜、望月慎一、山吉麻子、崔成源、狩野有宏、丸山厚

    第28回日本バイオマテリアル学会  2007.11 

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    Venue:東京   Country:Japan  

  • 部分二重鎖プローブによる一変異認識における単鎖構造の影響

    村木健太郎、石井大輔、穴井太郎、狩野有宏、山吉麻子、丸山厚

    第28回日本バイオマテリアル学会  2007.11 

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    Venue:東京   Country:Japan  

  • DNA二重鎖形成に及ぼすpoly(L-lysine)-g-dextran共重合体の影響

    森山塁、佐藤雄一、崔成源、狩野有宏、山吉麻子、丸山厚

    第28回日本バイオマテリアル学会  2007.11 

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    Venue:東京   Country:Japan  

  • 部分二重鎖DNAプローブを用いたハイスループット一塩基多型検出

    石井智也、村木健太郎、嶋田直彦、狩野有宏、西田奈央、徳永勝士、丸山厚

    第6回ナノ学会  2008.5 

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    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • DNA部分二重鎖プローブを用いた一塩基変異多型検出のハイスループット化

    石井智也、村木健太郎、嶋田直彦、狩野有宏、西田奈央、徳永勝士、丸山厚

    第57回高分子学会  2008.5 

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    Venue:横浜   Country:Japan  

  • 部分二重鎖プローブとカチオン性くし型共重合体を使ったハイスループットジェノタイピング

    嶋田直彦、村木健太郎、石井智也、中村麻子、狩野有宏、西田奈央、徳永勝士、丸山厚

    第18回バイオ高分子シンポジウム  2008.7 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Poly(L-lysine)-graft-dextran acts as a nucleic acid chaperone for tetramolecular quadruplex formation International conference

    Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

    Joint Symposium of 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chemistry  2008.9 

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    Country:Japan  

  • ヒアルロン酸グラフト共重合体による核酸デリバリー法の開発とその評価

    城山宗一郎、狩野有宏、望月慎一、嶋田直彦、丸山厚

    第57回高分子討論会  2008.9 

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    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

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MISC

  • がん細胞分泌性免疫抑制因子の同定による腫瘍悪性化機構の解明

    狩野有宏

    2019.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    Cancer Immune Surveillanceとして1950年代に提案された概念は、免疫チェックポイント阻害剤や、CAR-T療法の開発によってがんの免疫治療として結実した。現在、より効果的ながん免疫治療を目指し、ネオアンチゲンなど、がん抗原の研究が盛んに行われている。一方で、がんは腫瘍抗原やHLAクラスI抗原のダウンレギュレーション、デスレセプターシグナルや共刺激分子の欠損、PD-L1や免疫抑制性サイトカインの産生、そして制御性T細胞やMDSC (myeloid-derived suppressor cells) などのサプレッサー細胞の誘導といった、様々な手段によってCancer Immune Surveillanceを回避する1。筆者は培養脾臓細胞を評価系に使い、がん細胞の分泌物質が、活性化したリンパ球を抑制することを見いだした。その研究をここでご紹介したい。

  • PEGをグラフトしたポリ-L-リシンのsiRNAとの相互作用、および血中滞留性と腫瘍集積性の検討

    狩野有宏、丸山厚

    2011.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • DNAチップ・細胞チップ“ファイバー”スーパーバイオミメティックス

    狩野有宏、丸山厚

    株式会社エヌ・ティー・エス   2006.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • バイオナノマテリアルとしての多糖コンジュゲート

    望月慎一、狩野有宏、赤池敏宏、丸山厚

    高分子論文集   2004.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Professional Memberships

  • The Japanese Biochemical Society

  • The Molecular Biology Society of Japan

  • Japanese Society for Immunology

  • Japanese Society of Interferon & Cytokine Research

Committee Memberships

  • 日本化学会生体関連若手会   九州地区幹事   Domestic

    2009.4 - 2011.3   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:5

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:6

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Scientific Reports International contribution

    2017.3 - 2019.3

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2013

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    Type:Peer review 

    Number of peer-reviewed articles in Japanese journals:3

  • 日本側実行委員 International contribution

    2011.5 - 2011.6

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    Type:Competition, symposium, etc. 

    Number of participants:187

  • 座長(Chairmanship)

    日本バイオマテリアル学会 九州ブロック キックオフシンポジウム  ( 福岡 九州大学医学部百年講堂 ) 2011.3

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    Type:Competition, symposium, etc. 

  • 日本側世話人 International contribution

    2010.7

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    Type:Competition, symposium, etc. 

    Number of participants:31

  • 日本側実行委員 International contribution

    2010.6

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    Type:Competition, symposium, etc. 

    Number of participants:38

  • 座長(Chairmanship)

    第59回高分子年次大会  ( 横浜 ) 2010.5

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    Type:Competition, symposium, etc. 

  • 実行委員 International contribution

    ( 那覇 ) 2009.12

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    Type:Competition, symposium, etc. 

    Number of participants:25

  • 世話人

    第24回生体機能関連化学シンポジウム若手フォーラム  ( 福岡市 ) 2009.9

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    Type:Competition, symposium, etc. 

    Number of participants:50

  • 日本側実行委員 International contribution

    2009.5

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    Type:Competition, symposium, etc. 

    Number of participants:191

  • 日本側実行委員 International contribution

    2008.11

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    Type:Competition, symposium, etc. 

    Number of participants:166

  • 座長(Chairmanship)

    第24回日本DDS学会学術集会  ( 東京 ) 2008.6

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    Type:Competition, symposium, etc. 

  • 日本側実行委員 International contribution

    2008.6

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    Type:Competition, symposium, etc. 

    Number of participants:70

  • 座長(Chairmanship)

    ナノ学会第6回大会  ( 福岡 ) 2008.5

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    Type:Competition, symposium, etc. 

  • 実行委員 International contribution

    2007.12

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    Type:Competition, symposium, etc. 

    Number of participants:30

  • 実行委員 International contribution

    2007.7

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    Type:Competition, symposium, etc. 

    Number of participants:37

  • 日本側実行委員 International contribution

    2007.5

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    Type:Competition, symposium, etc. 

    Number of participants:35

  • 実行委員 International contribution

    ( 鹿児島県指宿市 ) 2007.1

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    Type:Competition, symposium, etc. 

    Number of participants:38

  • 日本側実行委員 International contribution

    2006.11

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    Type:Competition, symposium, etc. 

    Number of participants:27

  • 座長(Chairmanship)

    第18回生体機能関連化学若手の会サマースクール  ( 福岡 ) 2006.8 - Present

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    Type:Competition, symposium, etc. 

  • 運営協力者

    遺伝子・デリバリー研究会  ( 福岡 ) 2006.5 - Present

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    Type:Competition, symposium, etc. 

    Number of participants:150

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Research Projects

  • 日中韓フォーサイト事業 International coauthorship

    2006.10 - 2011.7

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    研究交流課題名:新しい細胞特異的非ウィルス型遺伝子キャリアシステム
     バイオテクノロジー産業において、現状では米国が支配的状況である。これまで、日本中心にアジア諸国でも基礎生物学領域には多くの資金と人材が投入されたが、一部を除いて欧米研究の後追い型が大方である。バイオテクノロジー分野で欧米諸国と対等なレベルになるには、バイオテクノロジー研究に新たなパラダイム変換を起こしうる要素技術の開発体制を強化することが不可欠である。非ウィルス型の遺伝子ベクター(キャリア)は、安全で低コストな遺伝子治療に欠かせない基盤技術である。これまで十年以上に渡って非ウィルス型遺伝子ベクターの研究が、欧米、日本を含め各国で進められてきたが、現在に至って臨床上意味のある効率と安全性を兼ね備えた非ウィルス型ベクターは実現していない。一方、日本において核酸化学、ドラッグデリバリー材料、高分子分子集合体化学が発展してきた。また、韓国では、遺伝子治療を目的とする核酸コンジュゲートと刺激応答性材料に関する研究が近年活発化している。さらに、中国では機能性高分子合成、生分解性高分子と生命科学分野に昨今めざましい発展を遂げている。非ウィルス型遺伝子ベクターの開発には、医、薬、工の連携が不可欠である。本研究交流では、すでに各国レベルで医・工・薬から構成される研究拠点を形成している研究グループを集約し、3国間交流を深め、最新知見を提供・共有することで、非ウィルス型ベクターを欧米諸国に先駆けて実現する上で不可欠となる材料の設計手法を構築する。同時に、材料科学を基盤とし、バイオテクノロジー材料の研究開発に必要となる生物学、医学、薬学、バイオテクノロジーの知見と研究手法を身につけた人材を育成する。

Educational Activities

  • Plan, teaching, and marking of the practice for under graduate students.
    Teaching and guiding for the thesis for master degree and graduation.
    Graduate School Lectures

Class subject

  • 生命化学

    2024.10 - 2024.12   Fall quarter

  • 生命有機化学基盤特論 e

    2024.6 - 2024.8   Summer quarter

  • 生命化学

    2023.10 - 2023.12   Fall quarter

  • 生命有機化学基盤特論 e

    2023.6 - 2023.8   Summer quarter

  • 生命化学

    2022.10 - 2022.12   Fall quarter

  • 生命有機化学基盤特論 e

    2022.6 - 2022.8   Summer quarter

  • 総合理工学修士実験

    2022.4 - 2023.3   Full year

  • 総合理工学修士演習

    2022.4 - 2023.3   Full year

  • 生命化学

    2021.10 - 2021.12   Fall quarter

  • 生命有機化学基盤特論 e

    2021.6 - 2021.8   Summer quarter

  • 物質理工学修士演習第一

    2021.4 - 2022.3   Full year

  • 物質理工学修士実験第一

    2021.4 - 2022.3   Full year

  • 生命有機化学

    2020.10 - 2021.3   Second semester

  • 生命有機化学

    2020.10 - 2021.3   Second semester

  • 物質理工学修士演習第一

    2020.4 - 2021.3   Full year

  • 物質理工学修士演習第一

    2020.4 - 2021.3   Full year

  • 物質理工学修士実験第一

    2020.4 - 2021.3   Full year

  • 物質理工学修士実験第一

    2020.4 - 2021.3   Full year

  • 課題集約演習

    2019.10 - 2020.3   Second semester

  • 生命有機化学

    2019.10 - 2020.3   Second semester

  • 物質理工学修士実験第一

    2019.4 - 2020.3   Full year

  • 物質理工学修士演習第一

    2019.4 - 2020.3   Full year

  • 生命有機化学

    2018.10 - 2019.3   Second semester

  • 物質理工学修士実験第一

    2018.4 - 2019.3   Full year

  • 物質理工学修士演習第一

    2018.4 - 2019.3   Full year

  • 物質理工学修士実験第一

    2018.4 - 2019.3   Full year

  • 物質理工学修士演習第一

    2018.4 - 2019.3   Full year

  • 生命有機化学基礎論

    2018.4 - 2018.9   First semester

  • エネルギー物質工学演習

    2017.10 - 2018.3   Second semester

  • 生命有機化学

    2017.10 - 2018.3   Second semester

  • 物質理工学修士実験第一

    2017.4 - 2018.3   Full year

  • Exercise for Doctoral Thesis

    2017.4 - 2018.3   Full year

  • 物質理工学修士演習第一

    2017.4 - 2018.3   Full year

  • 生命有機化学基礎論

    2017.4 - 2017.9   First semester

  • 分子の科学

    2016.10 - 2017.3   Second semester

  • 生命有機化学

    2016.10 - 2017.3   Second semester

  • 生体有機化学 (先端有機化学)

    2016.4 - 2017.3   Full year

  • 有機機器分析化学

    2016.4 - 2016.9   First semester

  • 生命有機化学基礎論

    2016.4 - 2016.9   First semester

  • 物質工学演習

    2015.10 - 2016.3   Second semester

  • 分子の科学

    2015.10 - 2016.3   Second semester

  • 生命有機化学

    2015.10 - 2016.3   Second semester

  • 生体有機化学 (先端有機化学)

    2015.4 - 2016.3   Full year

  • Fundamentals on Interdisciplinary Engineering Sciences, Material, Energy, Environment

    2015.4 - 2015.9   First semester

  • 有機機器分析化学

    2015.4 - 2015.9   First semester

  • 生命有機化学基礎論

    2015.4 - 2015.9   First semester

  • 生命有機化学

    2014.10 - 2015.3   Second semester

  • 分子の科学

    2014.10 - 2015.3   Second semester

  • 生体有機化学 (先端有機化学)

    2014.4 - 2015.3   Full year

  • Fundamentals on Interdisciplinary Engineering Sciences, Material, Energy, Environment

    2014.4 - 2014.9   First semester

  • 生命有機化学基礎論

    2014.4 - 2014.9   First semester

  • 有機機器分析化学

    2014.4 - 2014.9   First semester

  • 生命有機化学

    2013.10 - 2014.3   Second semester

  • 有機機器分析化学

    2013.4 - 2013.9   First semester

  • 生体分子有機化学

    2012.10 - 2013.3   Second semester

  • 安全学

    2012.10 - 2013.3   Second semester

  • 自然科学総合実験

    2012.10 - 2013.3   Second semester

  • 物質科学工学実験第3

    2012.10 - 2013.3   Second semester

  • 分子細胞生物学I

    2012.4 - 2012.9   First semester

  • 物質科学工学実験第3

    2011.10 - 2012.3   Second semester

  • 基礎化学熱力学

    2011.10 - 2012.3   Second semester

  • 安全学

    2011.10 - 2012.3   Second semester

  • 生体分子有機化学

    2011.10 - 2012.3   Second semester

  • 分子細胞生物学I

    2011.4 - 2011.9   First semester

  • 物質科学工学実験第3

    2010.10 - 2011.3   Second semester

  • 生体分子有機化学

    2010.10 - 2011.3   Second semester

  • 物質科学工学実験第3

    2009.10 - 2010.3   Second semester

  • 物質科学工学実験第3

    2008.10 - 2009.3   Second semester

▼display all

FD Participation

  • 2023.10   Role:Participation   Title:令和5年度先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.2   Role:Participation   Title:令和4年度先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.1   Role:Participation   Title:令和3年度先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.1   Role:Participation   Title:令和2年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.1   Role:Participation   Title:平成31年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.5   Role:Participation   Title:平成31年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.1   Role:Participation   Title:平成30年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.7   Role:Participation   Title:平成30年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.1   Role:Participation   Title:平成29年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2017.5   Role:Participation   Title:平成29年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.12   Role:Participation   Title:平成28年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.5   Role:Participation   Title:平成28年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.1   Role:Participation   Title:平成27年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.5   Role:Participation   Title:平成27年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.1   Role:Participation   Title:平成26年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.5   Role:Participation   Title:平成26年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.1   Role:Participation   Title:平成25年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.5   Role:Participation   Title:平成24年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.1   Role:Participation   Title:平成23年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.5   Role:Other   Title:平成23年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.1   Role:Participation   Title:平成23年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.5   Role:Participation   Title:平成23年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.2   Role:Participation   Title:工学府FD「工学教育の質向上」(九州大学工学部における工学教育に求められているもの)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:平成22年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.5   Role:Participation   Title:平成22年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.1   Role:Participation   Title:平成21年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.5   Role:Participation   Title:平成21年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.1   Role:Participation   Title:平成20年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2008.5   Role:Participation   Title:平成20年度第1回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.12   Role:Speech   Title:平成19年度第2回先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.5   Role:Participation   Title:先導研平成19年度第1回FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.4   Role:Participation   Title:第1回全学FD

    Organizer:University-wide

  • 2007.2   Role:Participation   Title:先導研FD・講演会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2005.4   Role:Participation   Title:第2回 全学FD

    Organizer:University-wide

▼display all

Other educational activity and Special note

  • 2010  Special Affairs 

     詳細を見る

    The 9th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and the International Workshop on Biomaterials 2010 was held in Changchun. This symposium was financially supported by Japan Society for the Promotion of Science. I worked on it as an executive committee in the Japanese side. Fourteen Japanese resercher and one graduate student were sent to this sympoium.

  • 2010  Special Affairs 

     詳細を見る

    Young Exchange Seminar for A3 Foresight Program that was held in Korea Advanced Institute of Science and Technology, Daejeon, Korea, from July 4 to 7, 2010, by the financial support of Japan Society for the Promotion of Science, JSPS. For this 4-day meeting, 10 graduate students, including from Kumamoto university were sent. I essentially contributed to this project.

Outline of Social Contribution and International Cooperation activities

  • Based on an agreement among JSPS, Korea Science and Engineering Foundation(KOSEF) and National Natural Science Foundation of China(NSFC), this program supports joint research conducted by researchers of Japan, China and Korea. The three countries(A3) work as consortium in advancing leading-edge research with an aim to establishing a top- level research hub in Asia.(Started from FY2005.)

Social Activities

  • ひらめき・ときめきサイエンス (研究成果の社会還元・普及活動)

    2006.11

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • オープンキャンパスでの公開実験

    2006.5

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 高校生への基礎実験指導

    修猷館高校  2005.10

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • オープンキャンパスでの公開実験

    2005.5

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

Acceptance of Foreign Researchers, etc.

  • 中国科学院長春応用化学研究所

    Acceptance period: 2010.5 - 2010.7   (Period):1 month or more

    Nationality:China

    Business entity:Japan Society for the Promotion of Science

  • 中国科学院長春応用化学研究所

    Acceptance period: 2010.5 - 2010.7   (Period):1 month or more

    Nationality:China

    Business entity:Japan Society for the Promotion of Science

  • Acceptance period: 2008.10 - 2010.9   (Period):1 month or more

    Nationality:China

    Business entity:Japan Society for the Promotion of Science

  • 中国科学院長春応用化学研究所

    Acceptance period: 2008.8 - 2008.9   (Period):1 month or more

    Nationality:China

    Business entity:Japan Society for the Promotion of Science

  • 中国科学院長春応用化学研究所

    Acceptance period: 2008.8 - 2008.9   (Period):1 month or more

    Nationality:China

    Business entity:Japan Society for the Promotion of Science

Travel Abroad

  • 2009.5 - 2009.6

    Staying countory name 1:China   Staying institution name 1:長春応用化学研究所

  • 2007.8

    Staying countory name 1:China   Staying institution name 1:長春応用化学研究所

  • 1998.9 - 2002.2

    Staying countory name 1:United States   Staying institution name 1:Yale University, School of Medicine