Updated on 2024/12/25

Information

 

写真a

 
KIDOAKI SATORU
 
Organization
Institute for Materials Chemistry and Engineering Department of Applied Molecular Chemistry Professor
Center for Future Chemistry (Concurrent)
Graduate School of Engineering (Concurrent)
Graduate School of Engineering Department of Mechanical Engineering(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0928022507
Profile
Biophysical chemistry for the basis of molecular design of the tissue-engineering materials 1. Mechanobio-materials to manipulate cell functions for biomedical enginneering 2. Protein biomechanics: Study on the mechanistic aspect of protein adsorption and protein-protein interactions 3. Matrix engineering: Development of the tissue-engineering matrix, scaffold, and devices 4. Physico-chemical study on the regulation of the higher-ordered structure and transport property of DNA 5. Biophysical chemistry on the mesoscopic systems: Study on the mechanism for molecular self-organization
External link

Research Areas

  • Nanotechnology/Materials / Polymer materials

  • Life Science / Biophysics

  • Life Science / Biomaterials

  • Life Science / Biomedical engineering

  • Nanotechnology/Materials / Bio chemistry

  • Nanotechnology/Materials / Nanomaterials

  • Nanotechnology/Materials / Nanobioscience

▼display all

Degree

  • Ph.D.

Research History

  • Kyushu University Institute for Materials Chemistry and Engineering Professor 

    2006.10 - Present

      More details

  • 国立循環器病センター研究所 流動研究員 科学技術振興機構 研究員   

    国立循環器病センター研究所 流動研究員 科学技術振興機構 研究員

Education

  • Nagoya University   School of Science   Department of Chemistry

    - 1993

      More details

    Country:Japan

    researchmap

Research Interests・Research Keywords

  • Research theme: Biomaterials

    Keyword: Biomaterials

    Research period: 2024

  • Research theme: 高分子集合体

    Keyword: 高分子集合体

    Research period: 2024

  • Research theme: 細胞バイオメカニクス

    Keyword: 細胞バイオメカニクス

    Research period: 2024

  • Research theme: 一分子観察

    Keyword: 一分子観察

    Research period: 2024

  • Research theme: ナノフォース測定

    Keyword: ナノフォース測定

    Research period: 2024

  • Research theme: Molecular Assembly Systems

    Keyword: Molecular Assembly Systems

    Research period: 2024

  • Research theme: Mechanobiology

    Keyword: Mechanobiology

    Research period: 2024

  • Research theme: Biomatrix engineering: Development of tissue engineering scaffold and drug delivery matrix with electrospinning methodology

    Keyword: Cell manipulation matrix

    Research period: 2002.6

  • Research theme: Mechanobio-materials: Design of micromechanical extracellular environment to manipulate cellular functions and behaviors

    Keyword: Nanobiomechanics, Mechanobiology, Mechanobio-materials, Mechanotaxis

    Research period: 2001.6

  • Research theme: Protein biomechanics: Mechanistic and thermodynamical studies on the protein-materials, protein-protein interactions

    Keyword: Molecular force measurement

    Research period: 1997.4

  • Research theme: DNA分子の高次構造制御および溶液・マトリックス中での移動・拡散過程の研究

    Keyword: 生体高分子直接観察、自己秩序分子集合体形成

    Research period: 1993.4

Papers

  • Actin arch formation induced by matrix deformability, Reviewed

    S. Masaike*, S. Kidoaki

    J. Biorheology   2024.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Glyoxal-methyl-ethylene sulfonic acid fixative enhances the fixation of cytoskeletal structures for Föster resonance energy transfer measurements Reviewed

    S. Kuriyama, T. Kuboki, G. Itoh, S. Kidoaki, M. Tanaka

    Histochemistry and Cell Biology   162   337 - 347   2024.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • A plasmonic metasurface reveals differential motility of breast cancer cell lines at initial phase of adhesion Reviewed International journal

    ST. Lee, T. Kuboki, S. Kidoaki, Y. Aida, Y Arima*, K. Tamada

    Colloids and Surfaces B: Biointerfaces   238   113876   2024.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cell Adhesion Control through Culture Substrate Design: Considerations for Incorporating Molecular Mechanisms of Adhesion Mechanics into Biomaterials Engineering Invited Reviewed International journal

    S. Masaike, S. Kidoaki

    Journal of Biomechanical Science and Engineering   18   23-00358   2024.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Local pH mapping in the cell adhesion nano-interfaces on a pH-responsive fluorescence-dye-immobilized substrate Reviewed International journal

    S. Masaike, Y. Tsuji, and S.Kidoaki

    Anal. Sci.   2023.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Guideline for design of substrate stiffness for mesenchymal stem cell culture based on heterogeneity of YAP and RUNX2 responses Reviewed International journal

    H. Miyoshi*, M, Yamazaki, H. Fujie, S. Kidoaki

    Biophysics and Physicobiology   2023.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity Reviewed International journal

    H. Ebata and S.Kidoaki,

    Biophysics and Physicobiology   2022.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Adhesive-ligand-independent cell-shaping controlled by the lateral deformability of a condensed polymer matrix

    Sayaka Masaike, Saori Sasaki, Hiroyuki Ebata, Kosuke Moriyama, Satoru Kidoaki

    POLYMER JOURNAL   54 ( 2 )   211 - 222   2021.11   ISSN:0032-3896 eISSN:1349-0540

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Polymer Journal  

    Cell adhesion on biomaterial surfaces has been extensively studied from the perspective of the adsorption properties of adhesive ligands, while recent research on mechanobiology has been revealing a critical role of the mechanical properties of the extracellular milieu in the control of cell adhesion, such as the stiffness and viscoelasticity of the matrix. Although the effects of the lateral mobility of an adhesive ligand have been intensively investigated in a model substrate with water-soluble polymer layers, less is known about those in the setting of lateral deformability of hydrophobic condensed polymer layers. In this study, to help clarify this issue, we used PNIPAAm-grafted substrates with a well-controlled degree of graft-polymerization (DGP) as a typical hydrophobic condensed polymer surface at a cell culture temperature of 37 degrees C. We observed a clear negative correlation between cell spreading and DGP of PNIPAAm regardless of the amount of fibronectin adsorbed on the substrates, which was found to be attributable to the lateral deformability of a condensed PNIPAAm layer based on lateral force microscopic analysis. The surface-lateral-deformation-induced modulation in stability and maturation of focal adhesion of the cells is discussed in relation to the matrix-strain-induced alteration of the density distribution of adsorbed adhesive ligands.

    DOI: 10.1038/s41428-021-00577-w

    Web of Science

    Scopus

  • Avoiding tensional equilibrium in cells migrating on a matrix with cell-scale stiffness-heterogeneity Reviewed International journal

    H. Ebata and S. Kidoaki

    Biomaterials, 120860, 2021.   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • High axial and lateral resolution on self-assembled gold nanoparticle metasurfaces for live-cell imaging Reviewed International journal

    S. Masuda,T. Kuboki, S. Kidoaki, S-T. Lee, S. Ryuzaki, K. Okamoto, Y. Arima, K. Tamada

    ACS Appl. Nano Mater.   3 ( 11 )   11135 - 11142   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Designing elastic modulus of cell culture substrate to regulate YAP and RUNX2 localization for controlling differentiation of human mesenchymal stem cells Reviewed International journal

    M. Yamazaki, S. Kidoaki, H. Fujie, H. Miyoshi

    Anal. Sci.   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Why epithelial cells collectively move against a traveling signal wave International journal

    T. Fukuyama, H. Ebata, Y. Kondo, S. Kidoaki, K. Aoki, Y. T. Maeda

    arXiv   2020.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • General cellular durotaxis induced with cell-scale heterogeneity of matrix-elasticity Reviewed International journal

    Hiroyuki Ebata, Kousuke Moriyama, Thasaneeya Kuboki, Satoru Kidoaki

    Biomaterials   230   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Stiffness-gradient-induced cellular taxis, so-called durotaxis, has been extensively studied on a substrate with a single broad or steep stiffness gradient. However, in actual living tissues, cells should sense cell-scaled heterogeneous elasticity distribution in the extracellular matrix. In this study, to clarify the effect of the cell-scale heterogeneity of matrix-elasticity on durotaxis, we examined the motility of different types of cells on microelastically-striped patterned gels with different cell-sized widths. We found that cells accumulated in stiff regions with specific width on cell-type-dependency, even when a stiffness gradient is too small to induce usual durotaxis with a monotonic stiffness gradient. Fibroblast cells accumulated in a wide stiff region of multicellular size, while mesenchymal stem cells localized in a narrow stiff region of single-cell size. It was revealed that durotactic activity is critically affected not only with the cell type but also with the cell-scale heterogeneity of matrix-elasticity. Based on the shape-fluctuation-based analysis of cell migration, the dynamics of the pseudopodia were found to play a key role in determining the behaviors of general durotaxis. Our results suggest that design of cell-scale heterogeneity of matrix-elasticity is pivotal in controlling directional cell migration, the spontaneous cell-patterning, and development of the tissue on the biomaterials surfaces.

    DOI: 10.1016/j.biomaterials.2019.119647

  • Hierarchical development of motile polarity in durotactic cells just crossing an elasticity boundary Reviewed International journal

    T. Kuboki, H. Ebata, T. Matsuda, Y. Arai, T. Nagai, S. Kidoaki

    Cell Struct. Funct.   45   33 - 43   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Stiffness-optimized drug-loaded matrix for selective capture and elimination of cancer cells Reviewed International journal

    D. Huang and S. Kidoaki

    J. Drug Deliv. Sci. Technol.   55   10414   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Mechanisms of endothelial cell coverage by pericytes computational modelling of cell wrapping and in vitro experiments Reviewed International journal

    Kei Sugihara, Saori Sasaki, Akiyoshi Uemura, Satoru Kidoaki, Takashi Miura

    Journal of the Royal Society, Interface   17 ( 162 )   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Pericytes (PCs) wrap around endothelial cells (ECs) and perform diverse functions in physiological and pathological processes. Although molecular interactions between ECs and PCs have been extensively studied, the morphological processes at the cellular level and their underlying mechanisms have remained elusive. In this study, using a simple cellular Potts model, we explored the mechanisms for EC wrapping by PCs. Based on the observed in vitro cell wrapping in three-dimensional PC-EC coculture, the model identified four putative contributing factors: preferential adhesion of PCs to the extracellular matrix (ECM), strong cell-cell adhesion, PC surface softness and larger PC size. While cell-cell adhesion can contribute to the prevention of cell segregation and the degree of cell wrapping, it cannot determine the orientation of cell wrapping alone. While atomic force microscopy revealed that PCs have a larger Young's modulus than ECs, the experimental analyses supported preferential ECM adhesion and size asymmetry. We also formulated the corresponding energy minimization problem and numerically solved this problem for specific cases. These results give biological insights into the role of PC-ECM adhesion in PC coverage. The modelling framework presented here should also be applicable to other cell wrapping phenomena observed in vivo.

    DOI: 10.1098/rsif.2019.0739

  • Precise design of microwrinkles through the independent regulation of elasticity on the surface and in the bulk of soft hydrogels Reviewed International journal

    Saori Sasaki, Satoru Kidoaki

    Polymer Journal   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Abstract: It is still difficult to precisely control microscopic wrinkles on the surface of functional materials, especially biomimetic soft hydrogels with an elastic modulus lower than 100 kPa. This is due to the difficulty in realizing the systematic and independent regulation of elasticity on the top surface and in the bulk of hydrogels, which is essential for the generation of surface microwrinkles. To overcome this problem, using a two-step photocrosslinking process with VIS and UV irradiation of a photocurable gelatinous sol, we developed a method for independently regulating the elastic modulus on the surface and in the bulk to obtain wrinkles on a biomimetic soft gel. Photocurable gelatin was first irradiated and crosslinked with VIS light in the presence of the water-soluble radical generator sulfonyl camphorquinone, which is effective in forming thick bulk gels. Next, the top surface of these precrosslinked gels was irradiated with UV light in the presence of surface-coated water-insoluble camphorquinone. As a result, this two-step photocrosslinking process enabled to independently control the elastic moduli of the surface and the bulk lower than 100 kPa and to generate several-micron-scale wrinkles on the soft hydrogel surface.

    DOI: 10.1038/s41428-019-0299-8

  • Characterization of 3D matrix conditions for cancer cell migration with elasticity/porosity-independent tunable microfiber gels Reviewed

    Daoxiang Huang, Yu Nakamura, Aya Ogata, Satoru Kidoaki

    Polymer Journal   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The mechanics and architectures of the extracellular matrix (ECM) critically influence 3D cell migration processes, such as cancer cell invasion and metastasis. Understanding the roles of mechanical and structural factors in the ECM could provide an essential basis for cancer treatment. However, it is generally difficult to independently characterize these roles due to the coupled changes in these factors in conventional ECM model systems. In this study, to solve this problem, we developed elasticity/porosity-tunable electrospun fibrous gel matrices composed of photocrosslinked gelatinous microfibers (nanometer-scale-crosslinked chemical gels) with well-regulated bonding (tens-of-micron-scale fiber-bonded gels). This system enables independent modulation of microscopic fiber elasticity and matrix porosity, i.e., the mechanical and structural conditions of the ECM. The elasticity of fibers was tuned with photocrosslinking conditions. The porosity was regulated by changing the degree of interfiber bonding. The influences of these factors of the fibrous gel matrix on the motility of MDA-MB-231 tumorigenic cells and MCF-10A nontumorigenic cells were quantitatively investigated. MDA-MB-231 cells showed the highest degree of MMP-independent invasion into the matrix composed of fibers with a Young’s modulus of 20 kPa and a low degree of interfiber bonding, while MCF-10A cells did not show invasive behavior under the same matrix conditions.

    DOI: 10.1038/s41428-019-0283-3

  • Frustrated differentiation of mesenchymal stem cells Reviewed

    Satoru Kidoaki

    Biophysical Reviews   11 ( 3 )   377 - 382   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Mesenchymal stem cells (MSCs) are one of the most useful cell resources for clinical application in regenerative medicine. However, standardization and quality assurance of MSCs are still essential problems because the stemness of MSCs depends on such factors as the collection method, individual differences associated with the source, and cell culture history. As such, the establishment of culture techniques which assure the stemness of MSCs is of vital importance. One important factor affecting MSCs during culture is the effect of the mechanobiological memory of cultured MSCs built up by their encounter with particular mechanical properties of the extracellular mechanical milieu. How can we guarantee that MSCs will remain in an undifferentiated state? Procedures capable of eliminating effects related to the history of the mechanical dose for cultured MSCs are required. For this problem, we have tried to establish the design of microelastically patterned cell-culture matrix which can effectively induce mechanical oscillations during the period of nomadic migration of cells among different regions of the matrix. We have previously observed before that the MSCs exposed to such a growth regimen during nomadic culture keep their undifferentiated state—with this maintenance of stemness believed due to lack of a particular regular mechanical dosage that is likely to determine a specific lineage. We have termed this situation as “frustrated differentiation”. In this minireview, I introduce the concept of frustrated differentiation of MSCs and show possibility of purposeful regulation of this phenomenon.

    DOI: 10.1007/s12551-019-00528-z

    Repository Public URL: https://hdl.handle.net/2324/7174491

  • Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells Reviewed

    Misato Iwashita, Hatsumi Ohta, Takahiro Fujisawa, Minyoung Cho, Makoto Ikeya, Satoru Kidoaki, Yoichi Kosodo

    Scientific reports   9 ( 1 )   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The mechanical properties of the extracellular microenvironment, including its stiffness, play a crucial role in stem cell fate determination. Although previous studies have demonstrated that the developing brain exhibits spatiotemporal diversity in stiffness, it remains unclear how stiffness regulates stem cell fate towards specific neural lineages. Here, we established a culture substrate that reproduces the stiffness of brain tissue using tilapia collagen for in vitro reconstitution assays. By adding crosslinkers, we obtained gels that are similar in stiffness to living brain tissue (150–1500 Pa). We further examined the capability of the gels serving as a substrate for stem cell culture and the effect of stiffness on neural lineage differentiation using human iPS cells. Surprisingly, exposure to gels with a stiffness of approximately 1500 Pa during the early period of neural induction promoted the production of dorsal cortical neurons. These findings suggest that brain-stiffness-mimicking gel has the potential to determine the terminal neural subtype. Taken together, the crosslinked tilapia collagen gel is expected to be useful in various reconstitution assays that can be used to explore the role of stiffness in neurogenesis and neural functions. The enhanced production of dorsal cortical neurons may also provide considerable advantages for neural regenerative applications.

    DOI: 10.1038/s41598-018-38395-5

  • Increasing Elasticity through Changes in the Secondary Structure of Gelatin by Gelation in a Microsized Lipid Space Reviewed

    Atsushi Sakai, Yoshihiro Murayama, Kei Fujiwara, Takahiro Fujisawa, Saori Sasaki, Satoru Kidoaki, Miho Yanagisawa

    ACS Central Science   4 ( 4 )   477 - 483   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Even though microgels are used in a wide variety of applications, determining their mechanical properties has been elusive because of the difficulties in analysis. In this study, we investigated the surface elasticity of a spherical microgel of gelatin prepared inside a lipid droplet by using micropipet aspiration. We found that gelation inside a microdroplet covered with lipid membranes increased Young's modulus E toward a plateau value E∗ along with a decrease in gel size. In the case of 5.0 wt % gelatin gelled inside a microsized lipid space, the E∗ for small microgels with R ≤ 50 μm was 10-fold higher (35-39 kPa) than that for the bulk gel (∼3 kPa). Structural analysis using circular dichroism spectroscopy and a fluorescence indicator for ordered beta sheets demonstrated that the smaller microgels contained more beta sheets in the structure than the bulk gel. Our finding indicates that the confinement size of gelling polymers becomes a factor in the variation of elasticity of protein-based microgels via secondary structure changes.

    DOI: 10.1021/acscentsci.7b00625

  • Persistent random deformation model of cells crawling on a gel surface Reviewed International journal

    H. Ebata, A. Yamamoto, Y. Tsuji, S. Sasaki, K. Moriyama, T. Kuboki, S. Kidoaki

    Sci. Rep.   8   5153   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cellular Durotaxis Revisited Initial-Position-Dependent Determination of the Threshold Stiffness Gradient to Induce Durotaxis Reviewed

    Kousuke Moriyama, Satoru Kidoaki

    Langmuir   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Directional cell movement from a softer to a stiffer region on a culture substrate with a stiffness gradient, so-called durotaxis, has attracted considerable interest in the field of mechanobiology. Although the strength of a stiffness gradient has been known to influence durotaxis, the precise manipulation of durotactic cells has not been established due to the limited knowledge available on how the threshold stiffness gradient (TG) for durotaxis is determined. In the present study, to clarify the principles for the manipulation of durotaxis, we focused on the absolute stiffness of the soft region and evaluated its effect on the determination of TG required to induce durotaxis. Microelastically patterned gels that differed with respect to both the absolute stiffness of the soft region and the strength of the stiffness gradient were photolithographically prepared using photo-cross-linkable gelatins, and the TG for mesenchymal stem cells (MSCs) was examined systematically for each stiffness value of the soft region. As a result, the TG values for soft regions with stiffnesses of 2.5, 5, and 10 kPa were 0.14, 1.0, and 1.4 kPa/μm, respectively, i.e., TG markedly increased with an increase in the absolute stiffness of the soft region. An analysis of the area and long-axis length for focal adhesions revealed that the adhesivity of MSCs was more stable on a stiffer soft region. These results suggested that the initial location of cells starting durotaxis plays an essential role in determining the TG values and furthermore that the relationship between the position-dependent TG and intrinsic stiffness gradient (IG) of the culture substrate should be carefully reconsidered for inducing durotaxis; IG must be higher than TG (IG ≥ TG). This principle provides a fundamental guide for designing biomaterials to manipulate cellular durotaxis.

    DOI: 10.1021/acs.langmuir.8b02529

  • LSPR-mediated high axial-resolution fluorescence imaging on a silver nanoparticle sheet Reviewed International journal

    K. Tamada, E. Usukura, Y. Yanase, A. Ishijima, T. Kuboki, S. Kidoaki, K. Okamoto.

    PLOS One   12 ( 12 )   e0189708   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • High-Resolution Imaging of a Cell-Attached Nanointerface Using a Gold-Nanoparticle Two-Dimensional Sheet Reviewed International journal

    S. Masuda, Y. Yanase, E. Usukura, S. Ryuzaki, P. Wang, K. Okamoto, T. Kuboki, S. Kidoaki, and K. Tamada

    Scientific Reports   7   3720   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Fabrication of Gold Microwires by Drying Gold Nanorods Suspensions Reviewed International journal

    Tomo Kurimura, Yoshiko Takenaka, Satoru Kidoaki, Masatoshi Ichikawa

    Adv. Mater. Interf.   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1002/admi.201601125

  • Reversible monolayer/spheroid cell culture switching by UCST-type thermoresponsive ureido polymers Reviewed International journal

    Naohiko Shimada, Minako Saito, Sayaka Shukuri, Sotaro Kuroyanagi, Thasaneeya Kuboki, Satoru Kidoaki, Takeharu Nagai, Atsushi Maruyama

    ACS Applied Mater. Interf.   8   31524 - 31529   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1021/acsami.6b07614

  • Fabrication of elasticity-tunable gelatinous gel for mesenchymal stem cell culture Invited Reviewed International journal

    T. Kuboki, S. Kidoaki

    Methods Mol. Biol.   1416   425 - 441   2016.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI 10.1007/978-1-4939-3584-0_25

  • Redox gene expression of adipose-derived stem cells in response to soft hydrogel Reviewed International journal

    Fahsai Kantawong, Thasaneeya Kuboki, Satoru Kidoaki

    Turkish Journal of Biology   39   682 - 691   2015.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Manipulation of cell mechanotaxis by designing curvature of the elasticity boundary on hydrogel matrix Reviewed International journal

    Ayaka Ueki, Satoru Kidoaki

    Biomaterials   2014.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Repository Public URL: https://hdl.handle.net/2324/7177954

  • Smart hydrogels exhibiting UCST-type volume changes under physiologically relevant conditions Reviewed International journal

    Naohiko Shimada, Satoru Kidoaki, Atsushi Maruyama

    RSC Advances   2014.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Time-dependent migratory behaviors in the long-term studies of fibroblast durotaxis on a hydrogel substrate fabricated with a soft band Reviewed International journal

    Thasaneeya Kuboki, Wei Chen, Satoru Kidoaki

    Langmuir   2014.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Rectified cell migration on saw-like micro-elastically patterned hydrogels with asymmetric gradient ratchet teeth Reviewed International journal

    Hiroyuki Sakashita, Satoru Kidoaki

    PLOS One   8 ( 10 )   e78067   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Morphology and adhesion strength of myoblast cells on photocurable gelatin under native and non-native micromechanical environments Reviewed International journal

    Hiroshi Yoshikawa, Takahito Kawano, Takehisa Matsuda, Satoru Kidoaki, Motomu Tanaka

    J. Phys. Chem. Part B   117   4081 - 4088   2013.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • S/O-nanodispersion electrospun fiber mesh effective for sustained release of healthy plasmid DNA with the structural and functional Integrity Reviewed International journal

    T. Okuda, Y. Tahara, N. Kamiya, M. Goto, and S. Kidoaki

    Journal of Biomaterials Science: Polymer Edition   24   1277 - 1290   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Rigidity-matching between cells and the extracellular matrix leads to the stabilization of cardiac conduction Reviewed International journal

    M. Horning, S. Kidoaki, T. Kawano, K. Yoshikawa

    Biophys. J.   102   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Multidrug delivery systems with single formulation ~current status and future perspective~ Reviewed International journal

    T. Okuda and S. Kidoaki

    Journal of Biomaterials and Nanobiotechnology   3   2012.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Elasticity boundary conditions required for cell mechanotaxis on microelastically-patterned gels Reviewed International journal

    T. Kawano and S. Kidoaki

    Biomaterials   2011.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    細胞は弾性基材表面の硬い領域を指向して運動する性質を示す(メカノタクシス)ことが知られていたが、その駆動のための表面弾性勾配の定量的条件は確立されておらず、メカノタクシスを系統的に誘導し制御することは不可能であった。本論文ではこの問題に対して、独自の弾性率可変ヒドロゲルのマイクロ弾性パターニング技術を確立することにより、細胞のメカノタクシスの誘導条件を初めて明確にした。その技術は細胞運動を操作する培養基材設計の一般的な基礎となるものである。

  • Thermo-Switching of the Conformation of Genomic DNA in Solutions of Poly-(N-isopropylacrylamide) Reviewed International journal

    N. Chen, A. Zinchenko, S. Kidoaki, M. Murata, K. Yoshikawa

    Langmuir   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes Reviewed International journal

    T. Okuda, K. Tominaga, S. Kidoaki

    Journal of Controlled Release   143 ( 2 )   2010.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Protein-peptide specific interaction-driven hydrogel formation, hydrodynamic shear stress-dependent gel-to-sol reversibility and its potential application to injectable cartilage tissue Reviewed International journal

    F. Ito, K. Usui, D. Kawahara, A. Suenaga, T. Maki, S. Kidoaki, H. Suzuki, M. Taiji, M. Itoh, Y. Hayashizaki, T. Matsuda

    Biomaterials   2009.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Nanoscale elongating control of the self-assembled protein filament with the cysteine-introduced building blocks Reviewed International journal

    K. Usui, T. Maki, F. Ito, A. Suenaga, S. Kidoaki, M. Itoh, M. Taiji, T. Matsuda, Y. Hayashizaki, H. Suzuki

    Protein Science   18   2009.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Microelastic gradient gelatinous gels to induce cellular mechanotaxis Reviewed International journal

    S. Kidoaki and T. Matsuda

    Journal of Biotechnology   2008.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Shape-engineered fibroblasts: cell elasticity and actin cytoskeletal features characterized by fluorescence and atomic force microscopy Reviewed International journal

    S. Kidoaki and T. Matsuda

    Journal of Biomedical Materials Research: Part A   81   2007.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Shape-engineered vascular endothelial cells: nitric oxide production, cell elasticity, and actin cytoskeletal features Reviewed International journal

    S. Kidoaki and T. Matsuda

    Journal of Biomedical Materials Research: Part A   81   2007.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Dynamic force spectroscopy of the specific interaction between PDZ-domain and its recognition peptides Reviewed International journal

    T. Maki, S. Kidoaki, K. Usui, H. Suzuki, M. Ito, F. Ito, Y. Hayashizaki, T. Matsuda

    Langmuir   2007.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Relationship between apical membrane elasticity and stress fiber organization in fibroblasts analyzed by fluorescence and atomic force microscopy Reviewed International journal

    S. Kidoaki, T. Matsuda, K. Yoshikawa

    Biomechan Model Mechanobiol   2006.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Mesoscopic spatial designs of nano- and micron-fiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques Reviewed International journal

    S. Kidoaki, I.K. Kwon, T. Matsuda

    Biomaterials   26 ( 1 )   37 - 46   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2004.01.063

  • Force measurement on antigen-antibody interaction by atomic force microscopy using photograft-polymer spacer Reviewed International journal

    A. Idiris, S. Kidoaki, K. Usui, T. Maki, H. Suzuki, M. Ito, M. Aoki, Y. Hayashizaki, T. Matsuda

    Biomacromolecules   6 ( 5 )   2776 - 2784   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bm0502617

  • Structural feature and mechanical property of in situ-bonded meshes of segmented polyurethane electrospun from mixed solvents Reviewed International journal

    S. Kidoaki, I.K. Kwon, T. Matsuda

    J. Biomed. Mater. Res. B   76B ( 1 )   219 - 229   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.b.30336

  • Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane mesh fabrics Reviewed International journal

    T. Matsuda, M. Ihara, H. Inoguchi, I.K. Kwon, K. Takamizawa, S. Kidoaki

    J. Biomed. Mater. Res. A   73A ( 1 )   125 - 131   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.a.30260

  • Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential Reviewed International journal

    I.K. Kwon, S. Kidoaki, T. Matsuda

    Biomaterials   26 ( 18 )   3929 - 3939   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2004.10.007

  • Poly(N-isopropylacrylamide) (PNIPAAM)-grafted hydrogel surfaces: Interrelationship between microscopic structures and mechanical property of surface regions and cell adhesiveness Reviewed International journal

    S. Ohya, S. Kidoaki, T. Matsuda

    Biomaterials   26 ( 16 )   3105 - 3111   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2004.08.006

  • Substrate-dependent Cellular Behaviors of Swiss 3T3 Fibroblasts and Activation of Rho Family during Adhesional and Spreading Processes Reviewed International journal

    S. Kato, S. Kidoaki, T. Matsuda

    J. Biomed. Mater. Res   68A ( 2 )   314 - 324   2004.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.a.20012

  • Photocurable biodegradable liquid copolymer: synthesis of acrylate-endcapped trimethylene carbonate-based prepolymers, photocuring and hydrolysis Reviewed International journal

    T. Matsuda, I.K. Kwon, S. Kidoaki

    Biomacromolecues   5 ( 2 )   295 - 305   2004.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bm034231k

  • Competition Between Compaction of Single Chains and Bundling of Multiple Chains in Giant DNA Molecules Reviewed International journal

    T. Iwataki, S. Kidoaki, T. Sakaue, K. Yoshikawa, and S. S. Abramuchuk

    J. Chem. Phys   2004.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity Reviewed International journal

    T. Matsuda, J. Nagase, A. Gouda, Y. Hirano, S. Kidoaki, and Y. Nakayama

    Biomaterials   24 ( 24 )   4517 - 4527   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0142-9612(03)00344-2

  • Photocontrol of Cell Adhesion and Proliferation by a Photoinduced Cationic Polymer Surface Reviewed International journal

    Y. Nakayama, A. Furumoto, S. Kidoaki and T. Matsuda

    Photochem. Photobiol.   77 ( 5 )   480 - 486   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1562/0031-8655(2003)077<0480:POCAAP>2.0.CO;2

  • Time-dependent complex formation of dendritic poly(L-lysine)s with plasmid DNA and correlation with in vitro transfection efficiencies Reviewed International journal

    T. Okuda, S. Kidoaki , M. Ohsakia, Y. Koyama, K. Yoshikawa

    Org. Biomol. Chem.   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Interaction of Double-stranded T4 DNA with Cationic Gel of Poly(Diallyldimethylammonium Chloride) Reviewed International journal

    S.G.Starodoubtsev, S.Kidoaki, K.Yoshikawa

    Biomacromolecules   4 ( 1 )   32 - 37   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bm025583e

  • Multi-scaling in a long semi-flexible polymer chain in 2D Reviewed International journal

    N. Yoshinaga, K. Yoshikawa, and S. Kidoaki

    J. Chem. Phys.   116 ( 22 )   9926 - 9929   2002.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1063/1.1475759

  • Measuerment of Interaction Forces Between Proteins and Iniferter-Based Graft-Polymerized Surfaces with an Atomic Force Microscope in an Aqueous Media Reviewed International journal

    S. Kidoaki, Y. Nakayama, and T. Matsuda

    Langmuir   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Thermo-Responsive Property of N-isopropylacrylmide Graft-Polymerized Surfaces Measured with an Atomic Force Microscope Reviewed International journal

    S. Kidoaki, S. Ohya, Y. Nakayama, and T. Matsuda

    Langmuir   2001.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cooperativity vs. Phase Transition in a Giant Single DNA Molecules Reviewed International journal

    T. Iwataki, Y. Yoshikawa, S. Kidoaki, D. Umeno, M. Kiji, M. Maeda

    J. Am. Chem. Soc   122 ( 41 )   9891 - 9896   2000.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja000230d

  • Folding and Unfolding of a Giant Duplex-DNA in a Mixed Solution with Polycations, Polyanions, and Crowding Neutral Polymers Reviewed International journal

    S. Kidoaki and K. Yoshikawa

    Biophys. Chem   1999.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Adhesion Forces of the Blood Plasma Proteins on Self-Assembled Monolayer Surfaces of Alkanethiolates with Different Functional Groups Measured by an Atomic Force Microscope Reviewed International journal

    S. Kidoaki and T. Matsuda

    Langmuir   1999.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Structure of Collapsed Persistent Macromolecule: Toroid vs. Spherical Globule Reviewed International journal

    V. V. Vasilevskaya, A. R. Khokhlov, S. Kidoaki and K. Yoshikawa

    Biopolymers   1997.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Gene Delivery Mediated by Polyarginine Requires a Formation of Big Carrier-Complex of DNA Aggregate Reviewed International journal

    N. Emi, S. Kidoaki, K. Yoshikawa and H. Saito

    Biochem. Biophys. Res. Commun   1997.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The Folded State of Long Duplex-DNA Chain Reflects Its Solution History Reviewed International journal

    S. Kidoaki and K. Yoshikawa

    Biophys. J.   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Self Organized Nanostructure Constructed with a Single Polymer Chain. Reviewed International journal

    H. Noguchi, S. Saito, S. Kidoaki and K. Yoshikawa

    Chem. Phys. Lett   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Marked Discreteness on The Coil-Globule Transition of Single Duplex-DNA Reviewed International journal

    K. Yoshikawa, S. Kidoaki, M. Takahashi, V. V. Vasilevskaya and A. R. Khokhlov

    Ber. Bunsen-Ges. Phys. Chem   1996.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 2D-DIGE proteomic analysis of mesenchymal stem cell cultured on the elasticity-tunable hydrogels Reviewed International journal

    T. Kuboki, F. Kantawong, R. Burchmore, M.J. Dalby, and S. Kidoaki

    Cell Structure and Function   1900

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Glyoxal-methyl-ethylene sulfonic acid fixative enhances the fixation of cytoskeletal structures for Förster resonance energy transfer measurements

    Kuriyama, S; Thasaneeya, K; Itoh, G; Kidoaki, S; Tanaka, M

    HISTOCHEMISTRY AND CELL BIOLOGY   162 ( 4 )   337 - 347   2024.6   ISSN:0948-6143 eISSN:1432-119X

     More details

    Language:English   Publisher:Histochemistry and Cell Biology  

    Förster resonance energy transfer (FRET) serves as a tool for measuring protein–protein interactions using various sensor molecules. The tension sensor module relies on FRET technology. In our study, this module was inserted within the actinin molecule to measure the surface tension of the cells. Given that the decay curve of FRET efficiency correlates with surface tension increase, precise and accurate efficiency measurement becomes crucial. Among the methods of FRET measurements, FRET efficiency remains the most accurate if sample fixation is successful. However, when cells were fixed with 4% paraformaldehyde (PFA), the actinin-FRET sensor diffused across the cytoplasm; this prompted us to explore fixation method enhancements. Glyoxal fixative has been reported to improve cytoskeletal morphologies compared to PFA. However, it was not known whether glyoxal fits FRET measurements. Glyoxal necessitates an acetic acid solution for fixation; however, acidic conditions could compromise fluorescence stability. We observed that the pH working range of glyoxal fixative aligns closely with MES (methyl-ethylene sulfonic acid) Good’s buffer. Initially, we switched the acidic solution for MES buffer and optimized the fixation procedure for in vitro and in vivo FRET imaging. By comparing FRET measurements on hydrogels with known stiffness to tumor nodules in mouse lung, we estimated in vivo stiffness. The estimated stiffness of cancerous tissue was harder than the reported stiffness of smooth muscle. This discovery shed lights on how cancer cells perceive environmental stiffness during metastasis.

    DOI: 10.1007/s00418-024-02304-x

    Web of Science

    Scopus

    PubMed

  • A plasmonic metasurface reveals differential motility of breast cancer cell lines at initial phase of adhesion

    Lee, ST; Kuboki, T; Kidoaki, S; Aida, Y; Arima, Y; Tamada, K

    COLLOIDS AND SURFACES B-BIOINTERFACES   238   113876   2024.6   ISSN:0927-7765 eISSN:1873-4367

     More details

    Language:English   Publisher:Colloids and Surfaces B: Biointerfaces  

    A plasmonic metasurface composed of a self-assembled monolayer of gold nanoparticles allows for fluorescence imaging with high spatial resolution, owing to the collective excitation of localized surface plasmon resonance. Taking advantage of fluorescence imaging confined to the nano-interface, we examined actin organization in breast cancer cell lines with different metastatic potentials during cell adhesion. Live-cell fluorescence imaging confined within tens of nanometers from the substrate shows a high actin density spanning < 1 μm from the cell edge. Live-cell imaging revealed that the breast cancer cell lines exhibited different actin patterns during the initial phase of cell adhesion (∼ 1 h). Non-tumorous MCF10A cells exhibited symmetric actin localization at the cell edge, whereas highly metastatic MDA-MB-231 cells showed asymmetric actin localization, demonstrating rapid polarization of MDA-MB-231 cells upon adhesion. The rapid actin organization observed by our plasmonic metasurface-based fluorescence imaging provides information on how quickly cancer cells sense the underlying substrate.

    DOI: 10.1016/j.colsurfb.2024.113876

    Web of Science

    Scopus

    PubMed

  • 2D/3D周囲力学場設計による幹細胞機能強化と組織構築

    木戸秋 悟

    Transactions of Japanese Society for Medical and Biological Engineering   Annual62 ( Abstract )   97_1 - 97_1   2024   ISSN:1347443X eISSN:18814379

     More details

    Language:Japanese   Publisher:Japanese Society for Medical and Biological Engineering  

    <p>幹細胞の周囲力学場の感受とメカノトランスダクション応答は、運動特性や分化特性、さまざまな生理活性分子の分泌特性の調節に深く関わるため、幹細胞を組織工学応用する際にはその培養環境力学場の系統的設計技術の拡充は本質的課題の一つである。我々はこれまでに間葉系幹細胞やiPS細胞に対して、これらの機能を強化もしくは最適制御する培養力学場の粘弾性の空間分布設計に取り組んできた。前者MSCに対しては、再生医療細胞医薬品としての応用に必須となる未分化保持および治療有効性因子の分泌性能の強化を可能とする環境力学場の設計原理の開拓を進め、治療有効性増強した幹細胞の識別を可能とする簡便な評価指標を開発した。後者iPS細胞に関しては、オルガノイドの再現性高く効率的な誘導を可能とする粘弾性マトリックスの設計指針を見出し、マトリゲル代替材料のプロトタイプを開発した。本発表では、これらの成果について紹介し、再生医療・組織構築に資する幹細胞操作マトリックスの設計例について議論する。</p>

    DOI: 10.11239/jsmbe.annual62.97_1

    CiNii Research

  • Musings on ‘Mu’

    KIDOAKI Satoru

    Seibutsu Butsuri   64 ( 4 )   177 - 177   2024   ISSN:05824052 eISSN:13474219

     More details

    Language:Japanese   Publisher:The Biophysical Society of Japan General Incorporated Association  

    DOI: 10.2142/biophys.64.177

    CiNii Research

  • Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers

    Hiroki Katsuta, Satoru Okuda, Kazuaki Nagayama, Hiroaki Machiyama, Satoru Kidoaki, Masashi Kato, Masahiro Sokabe, Takaki Miyata, Hiroaki Hirata

    iScience   26 ( 3 )   106090   2023.3   eISSN:2589-0042

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:iScience  

    Contractile force generated in actomyosin stress fibers (SFs) is transmitted along SFs to the extracellular matrix (ECM), which contributes to cell migration and sensing of ECM rigidity. In this study, we show that efficient force transmission along SFs relies on actin crosslinking by α-actinin. Upon reduction of α-actinin-mediated crosslinks, the myosin II activity induced flows of actin filaments and myosin II along SFs, leading to a decrease in traction force exertion to ECM. The fluidized SFs maintained their cable integrity probably through enhanced actin polymerization throughout SFs. A computational modeling analysis suggested that lowering the density of actin crosslinks caused viscous slippage of actin filaments in SFs and, thereby, dissipated myosin-generated force transmitting along SFs. As a cellular scale outcome, α-actinin depletion attenuated the ECM-rigidity-dependent difference in cell migration speed, which suggested that α-actinin-modulated SF mechanics is involved in the cellular response to ECM rigidity.

    DOI: 10.1016/j.isci.2023.106090

    Web of Science

    Scopus

    PubMed

    researchmap

  • pH応答性蛍光色素固定化基板上の細胞接着ナノ界面における局所pHマッピング(Local pH mapping in the cell adhesion nano-interfaces on a pH-responsive fluorescence-dye-immobilized substrate)

    Masaike Sayaka, Tsuji Yukie, Kidoaki Satoru

    Analytical Sciences   39 ( 3 )   347 - 355   2023.3   ISSN:0910-6340

     More details

    Language:English   Publisher:(公社)日本分析化学会  

    細胞接着界面における局所pH分布を可視化するため、pH応答性蛍光色素フルオレセインイソチオシアナート(FITC)で化学修飾したガラス基板を調製し、線維芽細胞(NIH/3T3)と癌細胞(HeLa)の接着界面におけるFITC蛍光強度の分布を観察し、FITC画像を観察した接着斑の分布と比較した。FITC画像を種々のpH培地で事前測定した表面固定化FITCのpH-蛍光校正データに基づいてpHマッピングに変換すると、HeLa細胞の厚い内周では細胞外側(pH7.4)よりpHが低下(6.8~7.0pH)している著しく大きな領域を認めたが、3T3細胞では薄い外周で小規模のpH低下領域を認めた。低下pH領域では多くの接着斑が重なり、画像解析ではインテグリン接着リガンド結合蓄積によるグリコカリックス圧縮促進を反映して、大きな接着斑が内部に低pH部を持つ傾向を認めた。この傾向は3T3細胞よりHeLaの方が強かった。

  • Local pH mapping in the cell adhesion nano-interfaces on a pH-responsive fluorescence-dye-immobilized substrate

    Sayaka Masaike, Yukie Tsuji, Satoru Kidoaki

    Analytical Sciences   39 ( 3 )   347 - 355   2023.3   ISSN:0910-6340 eISSN:1348-2246

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Cell-substrate adhesion nano-interfaces can, in principle, exhibit a spatial distribution of local pH values under the influence of the weakly acidic microenvironment of glycocalyx grafted on lipid bilayer cell membrane which is compressed and closely attached to culture substrate in the vicinity of integrin-adhesion complexes. However, a simple local pH distribution imaging methodology has not been developed. In this study, to visualize the local pH distribution at the cell adhesion interface, we prepared glass substrates chemically modified with a pH-responsive fluorescent dye fluorescein isothiocyanate (FITC), observed the distribution of FITC fluorescence intensity at the adhesion interface of fibroblast (NIH/3T3) and cancer cells (HeLa), and compared the FITC images with the observed distribution of focal adhesions. FITC images were converted to pH mapping based on the pH-fluorescence calibration data of surface-immobilized FITC pre-measured in different pH media, which showed significantly larger regions with lowered pH level (6.8–7.0) from outside the cell (pH 7.4) were observed at the thick inner periphery of HeLa cells while 3T3 cells exhibited smaller lowered pH regions at the thin periphery. The lowered pH regions overlapped with many focal adhesions, and image analysis showed that larger focal adhesions tend to possess more lowered pH sites inside, reflecting enhanced glycocalyx compression due to accumulated integrin-adhesion ligand binding. This tendency was stronger for HeLa than for 3T3 cells. The role of glycocalyx compression and the pH reduction at the cell adhesive interface is discussed. Graphical abstract: [Figure not available: see fulltext.]

    DOI: 10.1007/s44211-022-00239-8

    Web of Science

    Scopus

    PubMed

    researchmap

    Other Link: https://link.springer.com/article/10.1007/s44211-022-00239-8/fulltext.html

  • Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers, which ensures traction force exertion and cell migration Reviewed International journal

    H. Katsuta, S. Okuda, K. Nagayama, H. Machiyama, S. Kidoaki, M. Kato, M. Sokabe, T. Miyata, H. Hirata

    i Science   2023.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Cell Adhesion Control through the Design of Deformation and Friction Characteristics of Polymer Substrate Surfaces

    MASAIKE Sayaka, KIDOAKI Satoru

    The Proceedings of Mechanical Engineering Congress, Japan   2023 ( 0 )   F021-3   2023   eISSN:24242667

     More details

    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    <p>Cell adhesion control is a crucial challenge in the design of biomaterials to achieve specific cellular functions and applications. For instance, when implanting artificial organs into the human body, suppressing undesirable cell adhesion becomes essential to avoid adverse biological responses such as blood coagulation and thrombosis. On the other hand, for tissue reconstruction using cell scaffolding materials, ensuring appropriate cell adhesion to the material surface is required. Particularly, cell adhesion morphology is closely associated with cellular processes, including proliferation, differentiation, and orderly structural formation, making versatile control of cell adhesion indispensable in tissue engineering. Cell-substrate adhesion progresses through the binding of cell surface proteins, known as integrins, to adhesion ligands on the material surface. Therefore, the degree of cell adhesion can be manipulated by modulating the presentation of adhesion ligand quantity and its spatial density on the material surface. Traditional material design has focused on modifying adhesion ligand chemistry and physical adsorption characteristics. Additionally, numerous reports have highlighted the significance of material surface mechanics as essential variables in cell adhesion control. As cells exert traction forces on the adhesive substrate, the deformable substrate causes simultaneous movement of integrin-ligand pairs. Consequently, the deformation characteristics of the adhesion interface significantly influence the spatial distribution of adhesion ligands and the binding stability to integrins, representing vital design elements.</p>

    DOI: 10.1299/jsmemecj.2023.f021-3

    CiNii Research

  • Guideline for design of substrate stiffness for mesenchymal stem cell culture based on heterogeneity of YAP and RUNX2 responses

    Miyoshi Hiromi, Yamazaki Masashi, Fujie Hiromichi, Kidoaki Satoru

    Biophysics and Physicobiology   20 ( 2 )   n/a   2023   ISSN:2189-4779 eISSN:21894779

     More details

    Language:English   Publisher:The Biophysical Society of Japan  

    <p>Mesenchymal stem cells (MSCs) have the potential for self-renewal and multipotency to differentiate into various lineages. Thus, they are of great interest in regenerative medicine as a cell source for tissue engineering. Substrate stiffness is one of the most extensively studied exogenous physical factors; however, consistent results have not always been reported for controlling MSCs. Conventionally used stiff culture substrates, such as tissue-culture polystyrene and glass, enhance nuclear localization of a mechanotransducer YAP and a pre-osteogenic transcription factor RUNX2, and bias MSCs towards the osteogenic lineage, even without osteogenic-inducing soluble factors. The mechanosensitive nature and intrinsic heterogeneity present challenges for obtaining reproducible results. This review summarizes the heterogeneity in human MSC response, specifically, nuclear/cytoplasmic localization changes in the mechanotransducer yes-associated protein (YAP) and the osteogenic transcription factor RUNX2, in response to substrate stiffness. In addition, a perspective on the intracellular factors attributed to response heterogeneity is discussed. The optimal range of stiffness parameters, Young’s modulus, for MSC expansion culture to suppress osteogenic differentiation bias through the suppression of YAP and RUNX2 nuclear localization, and cell cycle progression is likely to be surprisingly narrow for a cell population from an identical donor and vary among cell populations from different donors. We believe that characterization of the heterogeneity of MSCs and understanding their biological meaning is an exciting research direction to establish guidelines for the design of culture substrates for the sophisticated control of MSC properties.</p>

    DOI: 10.2142/biophysico.bppb-v20.0018

    Web of Science

    Scopus

    PubMed

    CiNii Research

  • Cell adhesion control through culture substrate design (Considerations for incorporating molecular mechanisms of adhesion mechanics into biomaterials engineering)

    MASAIKE Sayaka, KIDOAKI Satoru

    Journal of Biomechanical Science and Engineering   18 ( 4 )   23-00358 - 23-00358   2023   ISSN:18809863 eISSN:18809863

     More details

    Language:English   Publisher:The Japan Society of Mechanical Engineers  

    <p>Cell adhesion to the extracellular matrix critically influences essential cellular functions such as proliferation, motility, and differentiation, all of which are crucial for maintaining tissue homeostasis. Achieving precise control over cell adhesion to artificial substrates is a pivotal challenge in biomaterials engineering. This minireview aims to elucidate the multifaceted considerations for substrate surface design, grounded in the detailed molecular mechanisms of the cell adhesion complex. We systematically outline key design variables for controlling cell adhesion, such as the spatial arrangement of adhesion ligands, matrix stiffness, and surface lateral deformation. The review also delves into the emerging role of mechanobiology of membrane glycocalyx, with a particular focus on the impact on the formation of focal adhesion complexes. Collectively, these considerations offer a methodology for fine-tuned control of cell adhesion and its subsequent cellular functions on engineered biomaterials.</p>

    DOI: 10.1299/jbse.23-00358

    Scopus

    CiNii Research

  • Hierarchical Development of Motile Polarity in Durotactic Cells Just Crossing an Elasticity Boundary

    Kuboki Thasaneeya, Ebata Hiroyuki, Matsuda Tomoki, Arai Yoshiyuki, Nagai Takeharu, Kidoaki Satoru

    Cell Structure and Function   45 ( 1 )   33 - 43   2022.2   ISSN:03867196 eISSN:13473700

     More details

    Language:English   Publisher:Japan Society for Cell Biology  

    Abstract Cellular durotaxis has been extensively studied in the field of mechanobiology. In principle, asymmetric mechanical field of a stiffness gradient generates motile polarity in a cell, which is a driving factor of durotaxis. However, the actual process by which the motile polarity in durotaxis develops is still unclear. In this study, to clarify the details of the kinetics of the development of durotactic polarity, we investigated the dynamics of both cell-shaping and the microscopic turnover of focal adhesions (FAs) for Venus-paxillin-expressing fibroblasts just crossing an elasticity boundary prepared on microelastically patterned gels. The Fourier mode analysis of cell-shaping based on a persistent random deformation model revealed that motile polarity at a cell-body scale was established within the first few hours after the leading edges of a moving cell passed through the boundary from the soft to the stiff regions. A fluorescence recovery after photobleaching (FRAP) analysis showed that the mobile fractions of paxillin at FAs in the anterior part of the cells exhibited an asymmetric increase within several tens of minutes after cells entered the stiff region. The results demonstrated that motile polarity in durotactic cells is established through the hierarchical step-wise development of different types of asymmetricity in the kinetics of FAs activity and cell-shaping with a several-hour time lag.

    CiNii Research

  • Transient Nascent Adhesion at the Initial Stage of Cell Adhesion Visualized on a Plasmonic Metasurface

    Lee, ST; Kuboki, T; Kidoaki, S; Aida, Y; Ryuzaki, S; Okamoto, K; Arima, Y; Tamada, K

    ADVANCED NANOBIOMED RESEARCH   2 ( 1 )   2022.1   ISSN:2699-9307

     More details

    Publisher:Advanced NanoBiomed Research  

    A plasmonic metasurface composed of self-assembled gold nanoparticles enables high-speed interfacial imaging with high axial and lateral resolution down to the theoretical limit under a widefield microscope. This high-spatiotemporal resolution imaging method monitors “early molecular events” in the adhesion of 3T3 fibroblasts expressing Venus-paxillin and LifeAct-mScarlet, revealing unique transient cell dynamics. Upon attaching to the SiO2-coated plasmonic metasurface, cells exhibit fibrous nascent adhesions spreading radially at the periphery, together with actively moving membrane blebs. These fibrous nascent structures exist transiently during passive spreading and disappear upon transition to active spreading with mature focal adhesions (FAs). The structure forms on a poor-cell-adhesive SiO2-coated surface but not on a fibronectin-preadsorbed cell-adhesive surface, suggesting that it temporarily anchors cells to the interface but maintains freedom before active cell spreading. These momentary molecular-level phenomena at the nanointerface are successfully captured by the herein described high-spatiotemporal resolution live-cell imaging method using a plasmonic metasurface.

    DOI: 10.1002/anbr.202100100

    Web of Science

    Scopus

  • 細胞操作変数としての高分子基材の変形特性

    木戸秋 悟

    高分子   71   164 - 168   2022

     More details

  • Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity

    Ebata Hiroyuki, Kidoaki Satoru

    Biophysics and Physicobiology   19 ( 0 )   n/a   2022   ISSN:2189-4779 eISSN:21894779

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Biophysical Society of Japan  

    <p>In living tissues where cells migrate, the spatial distribution of mechanical properties, especially matrix stiffness, is generally heterogeneous, with cell scales ranging from 10 to 1000 μm. Since cell migration in the body plays a critical role in morphogenesis, wound healing, and cancer metastasis, it is essential to understand the migratory dynamics on the matrix with cell-scale stiffness heterogeneity. In general, cell migration is driven by the extension and contraction of the cell body owing to the force from actin polymerization and myosin motors in the actomyosin cytoskeleton. When a cell is placed on a matrix with a simple stiffness gradient, directional migration called durotaxis emerges because of the asymmetric extension and contraction of the pseudopodia, which is accompanied by the asymmetric distribution of focal adhesions. Similarly, to determine cell migration on a matrix with cell-scale stiffness heterogeneity, the interaction between cell-scale stiffness heterogeneity and cellular responses, such as the dynamics of the cell-matrix adhesion site, intracellular prestress, and cell shape, should play a key role. In this review, we summarize systematic studies on the dynamics of cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity using micro-elastically patterned hydrogels. We also outline the cell migration model based on cell-shaping dynamics that explains the general durotaxis induced by cell-scale stiffness heterogeneity. This review article is an extended version of the Japanese article, Dynamics of Cell Shaping and Migration on the Matrix with Cell-scale Stiffness-heterogeneity, published in SEIBUTSU BUTSURI Vol. 61, p. 152–156 (2021).</p>

    DOI: 10.2142/biophysico.bppb-v19.0036

    Web of Science

    Scopus

    PubMed

    CiNii Research

    researchmap

  • Lipid membrane effect on the elasticity of gelatin microgel prepared inside lipid microdroplets Reviewed

    Atsushi Sakai, Naomi Hiro-oka, Saori Sasaki, Satoru Kidoaki, Miho Yanagisawa

    Nihon Reoroji Gakkaishi   47 ( 2 )   55 - 59   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    In a previous study (Sakai A., et al., ACS Cent. Sci., 4, 477 (2018)), a spherical microgel of gelatin prepared inside a lipid droplet was reported to have a higher surface elasticity than the bulk gel. In this study, we investigate the role of contact or lack of contact between gelatin and the lipid membrane as well as the micrometric confinement to isolate the dominant cause of this higher elasticity of microgels. For our experiment, we prepared a concave microgel of gelatin with two surfaces, with one surface in contact with the lipid membrane and the other without being in contact with the membrane. Next, we measured the elasticities of both the surfaces by using micropipette aspiration. Although the elasticity of the surface not in contact with the lipid membrane was slightly lower than that of the surface in contact with the membrane, the elasticity value was much higher than that for the bulk gel. Further, it was found that the droplet confinement without lipids did not decrease the elasticity of gelatin microgels. These results demonstrate that the dominant factor responsible for the higher elasticity of gelatin microgels is micrometric confinement and not their contact with the lipid membrane.

    DOI: 10.1678/rheology.47.55

  • High-resolution imaging of a cellattached nanointerface using a gold-nanoparticle two-dimensional sheet Reviewed

    Shihomi Masuda, Yuhki Yanase, Eiji Usukura, Sou Ryuzaki, Pangpang Wang, Koichi Okamoto, Thasaneeya Kuboki, Satoru Kidoaki, Kaoru Tamada

    SCIENTIFIC REPORTS   7 ( 1 )   3720   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This paper proposes a simple, effective, non-scanning method for the visualization of a cell-attached nanointerface. The method uses localized surface plasmon resonance (LSPR) excited homogeneously on a two-dimensional (2D) self-assembled gold-nanoparticle sheet. The LSPR of the gold-nanoparticle sheet provides high-contrast interfacial images due to the confined light within a region a few tens of nanometers from the particles and the enhancement of fluorescence. Test experiments on rat basophilic leukemia (RBL-2H3) cells with fluorescence-labeled actin filaments revealed high axial and lateral resolution even under a regular epifluorescence microscope, which produced higher quality images than those captured under a total internal reflection fluorescence (TIRF) microscope. This non-scanning-type, high-resolution imaging method will be an effective tool for monitoring interfacial phenomena that exhibit relatively rapid reaction kinetics in various cellular and molecular dynamics.

    DOI: 10.1038/s41598-017-04000-4

  • Characterization of the Frustrated Differentiation of Mesenchymal Stem Cells Induced by Normadic Migration Between Stiff and Soft Region of Gel Matrix Reviewed

    Satoru Kidoaki, Hiroyuki Ebata, Rumi Sawada, Kousuke Moriyama, Thasaneeya Kuboki, Yukie Tsuji, Ken Kono, Kazusa Tanaka, Saori Sasaki

    BIOPHYSICAL JOURNAL   112 ( 3 )   436A - 436A   2017.2

     More details

    Language:English  

    DOI: 10.1016/j.bpj.2016.11.2328

  • Corrigendum to "Elasticity boundary conditions required for cell mechanotaxis on microelastically-patterned gels" [Biomaterials 32(2011) 2725-33] Reviewed

    Takahito Kawano, Satoru Kidoaki

    Biomaterials   34 ( 30 )   7563 - 7564   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2013.06.011

  • Rectified Cell Migration on Saw-Like Micro-Elastically Patterned Hydrogels with Asymmetric Gradient Ratchet Teeth Reviewed

    Satoru Kidoaki, Hiroyuki Sakashita

    PLOS ONE   8 ( 10 )   e78067   2013.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To control cell motility is one of the essential technologies for biomedical engineering. To establish a methodology of the surface design of elastic substrate to control the long-range cell movements, here we report a sophisticated cell culture hydrogel with a micro-elastically patterned surface that allows long-range durotaxis. This hydrogel has a sawlike pattern with asymmetric gradient ratchet teeth, and rectifies random cell movements. Durotaxis only occurs at boundaries in which the gradient strength of elasticity is above a threshold level. Consequently, in gels with unit teeth patterns, durotaxis should only occur at the sides of the teeth in which the gradient strength of elasticity is above this threshold level. Therefore, such gels are expected to support the long-range biased movement of cells via a mechanism similar to the Feynman-Smoluchowski ratchet, i.e., rectified cell migration. The present study verifies this working hypothesis by using photolithographic microelasticity patterning of photocurable gelatin gels. Gels in which each teeth unit was 100-120 mu m wide with a ratio of ascending: descending elasticity gradient of 1: 2 and a peak elasticity of ca. 100 kPa supported the efficient rectified migration of 3T3 fibroblast cells. In addition, long-range cell migration was most efficient when soft lanes were introduced perpendicular to the saw-like patterns. This study demonstrates that asymmetric elasticity gradient patterning of cell culture gels is a versatile means of manipulating cell motility.

    DOI: 10.1371/journal.pone.0078067

  • S/O-nanodispersion electrospun fiber mesh effective for sustained release of healthy plasmid DNA with the structural and functional integrity Reviewed

    Tatsuya Okuda, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto, Satoru Kidoaki

    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION   24 ( 10 )   1277 - 1290   2013.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Localized and sustained delivery of the therapeutic genes using a solid carrier matrix is a potential approach to develop highly curative treatments. Electrospun nanofiber mesh of biodegradable polymer has been applied extensively as a carrier for localized and sustained delivery of drugs, proteins, and DNA, but it remains difficult to release sufficient amounts of DNA while maintaining structural and functional integrity. To realize the stable sustained release of the healthy plasmid DNA (pDNA) from electrospun fiber mesh, a novel method was examined for loading pDNA into the fibers based on solid-in-oil (S/O) nanodispersion of pDNA in organic solvent for electrospinning polymer solution: S/O nanodispersion electrospinning. A prepared pDNA-loaded fiber mesh made of biodegradable polymer showed sustained release of pDNA without burst release. From luciferase activity-based in vitro transcriptiontranslation assay, pDNA released from meshes of the S/O nanodispersion retained about 60% luciferase activity of control pDNA, whereas pDNA released from the meshes of simple mixing showed only about 5% activity, indicating that S/O nanodispersion electrospinning is effective for loading pDNA into electrospun fiber meshes while maintaining their healthy functions. Effectiveness of S/O nanodispersion electrospinning was verified for fabricating a sustained release carrier matrix for high molecular weight bioactives, including therapeutic genes.

    DOI: 10.1080/09205063.2012.755600

  • Morphology and Adhesion Strength of Myoblast Cells on Photocurable Gelatin under Native and Non-native Micromechanical Environments Reviewed

    Hiroshi Y. Yoshikawa, Takahito Kawano, Takehisa Matsuda, Satoru Kidoaki, Motomu Tanaka

    JOURNAL OF PHYSICAL CHEMISTRY B   117 ( 15 )   4081 - 4088   2013.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    We have quantitatively determined how the morphology and adhesion strength of myoblast cells can be regulated by photocurable gelatin gels, whose mechanical properties can be fine-tuned by a factor of 10(3) (0.1 kPa <= E <= 140 kPa). The use of such gels allows for the investigation of mechanosensing of cells not only near the natural mechanical microenvironments (E similar to 10 kPa) but also far below and beyond of the natural condition. Optical microscopy and statistical image analysis revealed that myoblast cells sensitively adopt their morphology in response to the substrate elasticity at E similar to 1-20 kPa, which can be characterized by the significant changes in the contact area and order parameters of actin cytoskeletons. In contrast, the cells in contact with the gels with lower elastic moduli remained almost round, and the increase in the elasticity beyond E similar to 20 kPa caused no distinct change in morphology. In addition to the morphological analysis, the adhesion strength was quantitatively evaluated by measuring the critical detachment pressure with an aid of intensive pressure waves induced by picosecond laser pulses. This noninvasive technique utilizing extremely short pressure waves (pulse time width similar to 100 ns) enables one to determine the critical pressure for cell detachment with reliable statistics while minimizing the artifacts arising from the inelastic deformation of cells. The adhesion strength also exhibited a transition from weak adhesion to strong adhesion within the same elasticity range (E similar to 1-20 kPa). A clear correlation between the cell morphology and adhesion strength suggests the coupling of the strain of the substrate and the mechanosensors near focal adhesion sites.

    DOI: 10.1021/jp4008224

  • Characterization of Complexes Formed by Mixing Aqueous Solutions of Poly(2-Ethyl-2-Oxazoline) and Poly(Methacrylic Acid) with a Wide Range of Concentrations Reviewed International journal

    Yasuhiro Matsuda, Kazumasa Takatsuji, Yasunori Shimokawa, Moriya Kikuchi, Satoru Kidoaki, Atsushi Takahara, Shigeru Tasaka

    Polymer   54   1896 - 1904   2013.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Detection of Prion Protein Oligomers by Single Molecule Fluorescence Imaging Reviewed

    S. Shibano, K. Sasaki, S. Kidoaki, T. Iwaki

    Neuropathology   2012.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Rigidity Matching between Cells and the Extracellular Matrix Leads to the Stabilization of Cardiac Conduction Reviewed

    Marcel Hoerning, Satoru Kidoaki, Takahito Kawano, Kenichi Yoshikawa

    BIOPHYSICAL JOURNAL   102 ( 3 )   379 - 387   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Biomechanical dynamic interactions between cells and the extracellular environment dynamically regulate physiological tissue behavior in living organisms, such as that seen in tissue maintenance and remodeling. In this study, the substrate-induced modulation of synchronized beating in cultured cardiomyocyte tissue was systematically characterized on elasticity-tunable substrates to elucidate the effect of biomechanical coupling. We found that myocardial conduction is significantly promoted when the rigidity of the cell culture environment matches that of the cardiac cells (4 kiloPascals). The stability of spontaneous target wave activity and calcium transient alternans in high frequency-paced tissue were both enhanced when the cell substrate and cell tissue showed the same rigidity. By adapting a simple theoretical model, we reproduced the experimental trend on the rigidity matching for the synchronized excitation. We conclude that rigidity matching in cell-to-substrate interactions critically improves cardiomyocyte-tissue synchronization, suggesting that mechanical coupling plays an essential role in the dynamic activity of the beating heart.

    DOI: 10.1016/j.bpj.2011.12.018

  • Frustrated Differentiation of Mesenchymal Stem Cell Cultured on Microelastically-Patterned Photocurable Gelatinous Gels Reviewed

    Satoru Kidoaki, Shuhei Jinnouchi

    BIOPHYSICAL JOURNAL   102 ( 3 )   716A - 716A   2012.1

     More details

    Language:English  

    DOI: 10.1016/j.bpj.2011.11.3885

  • Elasticity boundary conditions required for cell mechanotaxis on microelastically-patterned gels Reviewed

    Takahito Kawano, Satoru Kidoaki

    BIOMATERIALS   32 ( 11 )   2725 - 2733   2011.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Directional cell migration induced by a mechanical gradient on a substrate surface toward a harder region, so-called mechanotaxis or durotaxis, has recently drawn attention not only in the field of mechanobiology but also for possible cell manipulation in biomedical engineering. Before we can use mechanotaxis to control cell migration on a biomaterial surface, quantitative design criteria for a microelasticity gradient should be established. To clarify the conditions required to induce mechanotaxis, the effects of a microelasticity boundary on cell culture hydrogels have been systematically assessed with regard to fibroblast migration based on a custom-built reduction projection-type photolithographic microelasticity patterning system with elasticity-tunable photocurable styrenated gelatins, which is a thoroughly-improved system of our previous simple photomasking method [41]. As a result, the conditions required to induce mechanotaxis were found to include a certain threshold jump in elasticity (30-40 kPa) and a sufficiently narrow width of the elasticity boundary (50 pm) comparable to a single cell's adhered area, i.e., a sufficiently high gradient strength (30-40 kPa/50 pm in our gelatinous gel system). A significant asymmetric distribution of the number and size of focal adhesions across the elasticity boundary was confirmed to be one of the driving factors of mechanotaxis by indirect immunofluorescence microscopy, and mechanistic considerations in the design criteria are discussed. (C) 2011 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.biomaterials.2011.01.009

  • Cationic Comb-type Copolymers Do Not Cause Collapse but Shrinkage of DNA Molecules Reviewed

    Naotaka Sonda, Masanori Hirano, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, Atsushi Maruyama

    CHEMISTRY LETTERS   40 ( 3 )   250 - 251   2011.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    A flow-stretching assay was employed to elucidate polycation/DNA interactions at the single-molecule level. Bacteriophage lambda-DNA (48.5 kbp) was attached at one end to a PEG-modified glass surface and stretched by buffer flow. The stretched DNA had an approximate length of 12 mu m. Upon injection of polylysine homopolymer, the DNA folded into a globule structure within a few seconds. Injection of a polylysine graft copolymer having hydrophilic dextran side chains also induced collapse of the stretched DNA. In comparison to these polymer, a copolymer with higher graft content did not cause DNA collapse but rather caused 25% shrinkage of the extended DNA. These results were compared with those observed with unstretched DNA.

    DOI: 10.1246/cl.2011.250

  • Cationic Comb-type Copolymers Do Not Cause Collapse but Shrinkage of DNA Molecules Reviewed International journal

    N. Sonda, M. Hirano, N. Shimada, A. Kano, S. Kidoaki, A.Maruyama

    Chem. Lett.   2011.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Formation of Nanoporous Fibers by the Self-Assembly of Pyromellitic Diimide-Based Macrocycle Reviewed International journal

    T. Nakagaki, A. Harano, Y. Fuchigami, E. Tanaka, S. Kidoaki, T. Okuda, T. Iwanaga, K. Goto, T. Shinmyuzu

    Ang. Chem. Int. Ed.   2010.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Development of time-programmed, dual-release system using multilayered fiber mesh sheet by sequential electrospinning Reviewed International journal

    T. Okuda and S. Kidoaki

    Journal of Robotics and Mechatronics   2010.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes Reviewed

    Tatsuya Okuda, Kengo Tominaga, Satoru Kidoaki

    JOURNAL OF CONTROLLED RELEASE   143 ( 2 )   258 - 264   2010.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To develop a drug carrier that enables time-programmed dual release in a single formulation, multilayered drug-loaded biodegradable nanofiber meshes were designed using sequential electrospinning with the following construction: (i) first drug-loaded mesh (top), (ii) barrier mesh, (iii) second drug-loaded mesh, and (iv) basement mesh (bottom). The drug release speed and duration were controlled by designing morphological features of the electrospun meshes such as the fiber diameter and mesh thickness. Control of the timed release of the second drug-the retardation period-was accomplished by appropriate design of the barrier mesh thickness. An in vitro release experiment demonstrated that the tetra-layered construction described above with appropriate morphological features of each component mesh can provide timed dual release of the respective drugs. The time-programmed dual release system using the multilayered electrospun nanofiber meshes was demonstrated as a useful formulation for advanced multidrug combination therapy requiring regiospecific administration of different drugs at different times. The potential use of the present multilayered formulation is discussed for application to biochemical modulation as one administrative strategy for use in sequential chemotherapy employing multiple anti-tumor drugs. (C) 2010 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jconrel.2009.12.029

  • Thermo-Switching of the Conformation of Genomic DNA in Solutions of Poly (N-isopropylacrylamide) Reviewed

    Ning Chen, Anatoly A. Zinchenko, Satoru Kidoaki, Shizuaki Murata, Kenichi Yoshikawa

    LANGMUIR   26 ( 5 )   2995 - 2998   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. With this method, the conformation of long genomic DNA can be readily and reversibly switched between it very compact condensate and an unfolded macromolecule.

    DOI: 10.1021/la904375k

  • Development of Micropatterned Elastic Gelatinous gels to Control Cell Mechanotaxis Reviewed

    Satoru Kidoaki, Takahito Kawano, Hiroyuki Sakashita

    BIOPHYSICAL JOURNAL   98 ( 3 )   729A - 729A   2010.1

     More details

    Language:English  

    DOI: 10.1016/j.bpj.2009.12.3998

  • Reversible hydrogel formation driven by protein-peptide-specific interaction and chondrocyte entrapment Reviewed

    Fuyu Ito, Kengo Usui, Daigo Kawahara, Atsushi Suenaga, Tei Maki, Satoru Kidoaki, Harukazu Suzuki, Makoto Taiji, Masayoshi Itoh, Yoshihide Hayashizaki, Takehisa Matsuda

    BIOMATERIALS   31 ( 1 )   58 - 66   2010.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    We developed a hydrogel self-assembling method driven by the interaction between recombinant tax-interactive protein-1 (TIP1) with the PDZ domain in a molecule, which is fused to each end of the triangular trimeric CutA protein (CutA-TIP1), and a PDZ domain-recognizable peptide which is covalently bound to each terminus of four-armed poly(ethylene glycol) (PDZ-peptide-PEG). Genetic manipulation based on molecular-dynamic simulation generated a cell-adhesive RGD tripeptidyl sequence in the CutA loop region [CutA(RGD)-TIP1]. Spontaneous viscoelastic hydrogel formation occurred when either CutA-TIP1- or CutA(RGD)-TIP1-containing buffer solution and PDZ-peptide-PEG-containing buffer solutions were stoichiometrically mixed. Dynamic viscoelasticity measurement revealed shear stress-dependent reversible-phase transformation: a spontaneous viscoelastic hydrogel was formed at low shear stress, but it was transformed into a sol at high shear stress. Upon the cessation of shear, hydrogel was restored. When chondrocytes were pre-mixed with one of these two components containing buffer solutions, the stoichiometric mixed solution was also spontaneously gelled. Individual rounded cells and multicellular aggregates were entrapped within both hydrogels without substantial cellular impairment regardless of the presence or absence of RGD motif in the CutA-TIP1 molecule. The potential use of such a shear-sensitive hydrogel for injectable cell delivery into diseased or lost cartilage tissue is discussed. (C) 2009 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.biomaterials.2009.09.026

  • Vectorial control of cell movement by the design of microelasticity distribution of biomaterial surface International journal

    S. Kidoaki, T. Matsuda

    IEEE International Symposium on Micro-NanoMechatronics and Human Science   2008.11

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • Analysis of cationic comb-type copolymers/DNA interaction by the single molecular observation and intermolecular force measurement International journal

    M. Hirano, N. Shimada, A. Kano, S. Kidoaki, A. Maruyama

    Nucleic Acids Symposium Series   2008.7

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • Microelastic gradient gelatinous gels to induce cellular mechanotaxis Reviewed

    Satoru Kidoaki, Takehisa Matsuda

    JOURNAL OF BIOTECHNOLOGY   133 ( 2 )   225 - 230   2008.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The understanding and realization of directional cell movement towards a harder region of a cell culture substrate surface, so-called mechanotaxis, might provide a solid basis for a functional artificial extracellular matrix, enabling manipulation and elucidation of cell motility. The photolithographic surface microelasticity patterning method was developed for fabricating a cell-adhesive hydrogel with a microelasticity gradient (MEG) surface using photocurable styrenated gelatin to investigate the condition of surface elasticity to induce mechanotaxis as a basis for such substrate-elasticity-dependent control of cell motility. Patterned MEG gels consisting of different absolute surface elasticities and elasticity jumps were prepared. Surface elasticity and its two-dimensional distribution were characterized by microindentation tests using atomic force microscopy (AFM). From analyses of trajectories of 3T3 cell movement on each prepared MEG gel, two critical criteria of the elasticity jump and the absolute elasticity to induce mechanotaxis were identified: (1) a high elasticity ratio between the hard region and the soft one, and (2) elasticity of the softer region to provide medium motility. Design of these conditions was found to be necessary for fabricating an artificial extracellular matrix to control or manipulate cell motility. (c) 2007 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jbiotec.2007.08.015

  • 生体分子相互作用のエネルギーランドスケープ解析

    木戸秋 悟, 牧 禎, 松田 武久

    高分子   56 ( 10 )   844 - 844   2007.10

     More details

    Language:Japanese  

    Energy Landscape Analysis of the Biomolecular Interactions

    DOI: 10.1295/kobunshi.56.844

  • Characterization of the cellular biomechanical responses caused on microprocessed substrates: effect of micropatterned cell adhesiveness and microelasticity gradient, International journal

    S. Kidoaki and T. Matsuda

    IEEE International Symposium on Micro-NanoMechatronics and Human Science   5   2006.11

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • Structural features and mechanical properties of in situ-bonded meshes of segmented polyurethane electrospun from mixed solvents Reviewed

    Satoru Kidoaki, Il Keun Kwon, Takehisa Matsuda

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   76 ( 1 )   219 - 229   2006.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The relationships between the structural features and mechanical properties of electrospun segmented polyurethane (SPU) meshes and electrospinning parameters such as formulation (e.g., polymer concentration and solvent mixing ratio) and operation parameters (e.g., applied voltage, air gap, and flow rate) were studied with the use of a mixed-solvent system of tetrahydrofuran (THF) and N,N-dimethylacrylamide (DMF). After the relationships between the structure of electrospun SPU and the operation parameters under a fixed SPU concentration of single THF solution were established, SPU was electrospun from the mixed solvent of THF and DMF with different mixing ratios [DMF content: 5, 10, and 30% (v/v)]. Scanning electron microscopy showed that an increase in DMF ratio significantly enhances the degree of bonding between SPU fibers at contact sites and decreases the diameter of fibers formed. The porosimetric characterization showed the following: (1) The porosity of the electrospun SPU meshes decreased with an increase of DMF ratio. (2) The pore size distribution exhibited three representative peaks of different void sizes (i.e., approximately 5, 20, and 70 μm). (3) The proportion of the 20-μm void markedly decreased with an increase in DMF ratio. A tensile test on the meshes showed that an increase in DMF ratio induces an increase in elasticity of the mesh. Such a regulation of the structural features and mechanical properties of electrospun SPU meshes using a mixed-solvent system with low- and high-boiling-point solvents may be useful in the engineering of SPU-fiber based matrices or scaffolds. © 2005 Wiley Periodicals, Inc.

    DOI: 10.1002/jbm.b.30336

  • Mechanobiology of cell and tissue engineering and multi-scaled process engineering International journal

    T. Matsuda and S. Kidoaki

    IEEE International Symposium on Micro-NanoMechatronics and Human Science   5   203 - 205   2005.11

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • Force measurement for antigen-antibody interaction by atomic force microscopy using a photograft-polymer spacer Reviewed

    A Idiris, S Kidoaki, K Usui, T Maki, H Suzuki, M Ito, M Aoki, Y Hayashizaki, T Matsuda

    BIOMACROMOLECULES   6 ( 5 )   2776 - 2784   2005.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To determine the intermolecular force on protein-protein interaction (PPI) by atomic force microscopy (AFM), a photograft-polymer spacer for protein molecules on both surfaces of the substrate and AFM probe tip was developed, and its effectiveness was assessed in a PPI model of a pair of human serum albumin (HSA) and its monoclonal antibody (anti-HSA). A carboxylated photoiniferter, N-(dithiocarboxy)sarcosine, was derivatized on both surfaces of the glass substrate and AFM probe tip, and subsequently water-soluble nonionic vinyl monomers, NN-dimethylacrylamide (DMAAm), were graft-polymerized on them upon ultraviolet light irradiation. DMAAm-photograft-polymerized spacers with carboxyl groups at the growing chain end but with different chain lengths on both surfaces were prepared. The proteins were covalently bound to the carboxyl terminus of the photograft-polymer chain using a water-soluble condensation agent. The effects of the graft-spacer length on the profile of the force-distance curves and on the unbinding characteristics (unbinding force and unbinding distance) were examined in comparison with those in the case of the commercially available poly(ethylene glycol) (PEG) spacer. The frequency of the nonspecific adhesion force profile was markedly decreased with the use of the photograft spacers. Among the force curves detected, a high frequency of single-peak curves indicating the unbinding process of a single pair of proteins and a very low frequency of multiple-peak profiles were observed for the photograft spacers, regardless of the graft chain length, whereas a high frequency of no-force peaks was noted. These observations were in marked contrast with those for the PEG spacer. The force peak values determined ranged from 88 to 94 pN, irrespective of the type of spacer, while the standard deviation of force distribution observed for the photograft spacer was lower than that for the PEG spacer, indicating that the photograft spacers provide a higher accuracy of force determination.

    DOI: 10.1021/bm0502617

  • Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential Reviewed

    IK Kwon, S Kidoaki, T Matsuda

    BIOMATERIALS   26 ( 18 )   3929 - 3939   2005.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Nano- to micro-structured biodegradable poly(L-lactide-co-epsilon-caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50150, and 30/70), poly(L-lactide) (PLL) and poly(c-caprolactone) (PCL) were obtained using methylene chloride (MC) as a solvent. The PLL microfiber exhibited a nanoscale-pore structure with a pore diameter of approximately 200-800 mn at the surface and subsurface regions, whereas such a surface structure was hardly observed in other polymers containing CL. The microfiber fabric made of PLCL 50/50 was elastomeric. Nanoscale-fiber fabrics with PLCL 50/50 (approx. 0.3 or 1.2 mum in diameter) were electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent. Mercury porosimetry showed that the decrease in the fiber diameter of the fabric decreased porosity, but increased fiber density and mechanical strength. Human umbilical vein endothelial cells (HUVECs) were adhered well and proliferated on the small-diameter-fiber fabrics (0.3 and 1.2 mum in diameter), both of which are dense fabrics, whereas markedly reduced cell adhesion, restricted cell spreading and no signs of proliferation were observed on the large-diameter-fiber fabric (7.0 mum in diameter), The potential biomedical application of electrospun PLCL 50/50 was discussed. (C) 2004 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.biomaterials.2004.10.007

  • Poly(N-isopropylacrylamide) (PNIPAM)-grafted gelatin hydrogel surfaces: interrelationship between microscopic structure and mechanical property of surface regions and cell adhesiveness Reviewed

    S Ohya, S Kidoaki, T Matsuda

    BIOMATERIALS   26 ( 16 )   3105 - 3111   2005.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Poly(jV-isopropylacrylamide)-grafted gelatin (PNIPAM-gelatin) serves as a temperature-induced scaffold at physiological temperature. This study was aimed at determining the effect of the graft architecture of thermoresponsive PNIPAM-gelatin on the surface topography and elastic modulus of the hydrogels prepared with different architectured PNIPAM-gelatins: the surface topography and elastic modulus were determined by atomic force microscopy (AFM). PNIPAM-gelatin surfaces showed an irregularly concavo-convex structure with a vertical interval of approximately I pm regardless of the weight ratio of PNIPAM to gelatin (P/G: 5.8, 12, and 18). The elastic moduli of hydrogels varied at measured sites. The mean elastic moduli of PNIPAM-gelatin with the lowest P/G were low, but increased with increasing P/G. Human umbilical vein endothelial cells adhered and spread on PNIPAM-gelatin hydrogels with the highest P/G, whereas reduced adhesion and nonspreading, round-shaped cells resided on the hydrogels with lower P/Gs. Interrelationship between elastic modulus and cell adhesion and spreading potentials were discussed from physicochemical and cellular biomechanical viewpoints. (C) 2004 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.biomaterials.2004.08.006

  • Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics Reviewed

    Takehisa Matsuda, Maki Ihara, Hiroyuki Inoguchi, Il Keun Kwon, Keiichi Takamizawa, Satoru Kidoaki

    Journal of Biomedical Materials Research - Part A   73 ( 1 )   125 - 131   2005.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To fabricate a "mechano-active" tubular scaffold of nonwoven mesh-type small-diameter artificial graft made of the synthetic durable elastomer, segmented polyurethane, the fabrication technique of electrospinning on a mandrel under a high rotation speed and transverse movement was used. Emphasis was placed on how the rotation speed of the mandrel and the fusion or welding states of fibers at contact points affect the compliance (ease of intraluminal pressure-dependent circumferential inflation) and Young's modulus determined by uniaxial stretching in the longitudinal and circumferential directions. The results showed that a high rotation speed is attributed to exhibit isotropic mechanical properties in the entire range of applied strain but reduces the compliance, and a high fusion state, which is produced using a mixed solvent with a high content of high-boiling-point solvent, reduces the compliance but is expected to exhibit high durability in a continuously loaded pulsatile stress field in an arterial circulatory system. © 2005 Wiley Periodicals, Inc.

    DOI: 10.1002/jbm.a.30260

  • Characterization of novel bio-degradable segmented polyurethanes prepared from amino-acid based diisocyanate International journal

    A. Takahara, M. Hadano, T. Yamaguchi, H. Otsuka, S. Kidoaki, T. Matsuda

    Macromolecular Symp   224   207 - 217   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/masy.200550618

  • Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques Reviewed

    S Kidoaki, IK Kwon, T Matsuda

    BIOMATERIALS   26 ( 1 )   37 - 46   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To design a mesoscopically ordered structure of the matrices and scaffolds composed of nano- and microscale fiber meshes for artificial and tissue-engineering devices, two new electrospinning techniques are proposed: multilayering electrospinning and mixing electrospinning. First, the following four kinds of component polymers were individually electrospun to determine the conditions for producing stable nano- and microfibers by optimizing the formulation parameters (solvent and polymer concentration) and operation parameters (voltage, air gap, and flow rate) for each polymer: (a) type I collagen, (b) styrenated gelatin (ST-gelatin), (c) segmented polyurethane (SPU), and (d) poly(ethylene oxide). A trilayered electrospun mesh, in which individual fiber meshes (type I collagen, ST-gelatin, and SPU) were deposited layer by layer, was formed by sequential electrospinning; this was clearly visualized by confocal laser scanning microscopy. The mixed electrospun-fiber mesh composed of SPU and PEO was prepared by simultaneous electrospinning on a stainless-steel mandrel with high-speed rotation and traverse movement. A bilayered tubular construct composed of a thick SPU microfiber mesh as an outer layer and a thin type I collagen nanofiber mesh as an inner layer was fabricated as a prototype scaffold of artificial grafts, and visualized by scanning electron microscopy. (C) 2004 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.biomaterials.2004.01.063

  • Protein-protein interactions of the hyperthermophilic archaeon Pyrococcus horikoshii OT3 Reviewed International journal

    K. Usui, S. Katayama, M. Kanamori, C. Kai, M. Okada, J. Kawai, T. Arakawa, P. Carninci, K. Takio, M. Miyano, S. Kidoaki, T. Matsuda, Y. Hayashizaki, H. Suzuki.

    Genome Biology   6 ( 12 )   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/gb-2005-6-12-r98

  • Photocurable biodegradable liquid copolymers: Synthesis of acrylate-end-capped trimethylene carbonate-based prepolymers, photocuring, and hydrolysis Reviewed

    T Matsuda, IK Kwon, S Kidoaki

    BIOMACROMOLECULES   5 ( 2 )   295 - 305   2004.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Various photocurable liquid biodegradable trimethylene carbonate (TMC)-based (co)oligomers were prepared by ring-opening (co)polymerization of TMC with or without L-lactide (LL) using low molecular weight poly(ethylene glycol) (PEG) (mol wt 200, 600, or 1000) or trimethylolpropane (TMP) as an initiator. Resultant (co)oligomers were pastes, viscous liquids, or liquids at room temperature, depending on the monomer composition and monomer/initiator ratio. Liquid (co)oligomers were subsequently end-capped with acrylate groups. Upon visible-light irradiation in the presence of camphorquinone as a radical generator, rapid liquid-to-solid transformation occurred to produce photocured solid. The photocuring yield increased with photoirradiation time, photointensity, and camphorquinone concentration. The photocured polymers derived from low molecular weight PEG (PEG200) and TMP exhibited much reduced hydrolysis potential compared with PEG1000-derived polymers in terms of weight loss, water uptake, and swelling depth. Force-distance curve measurements by nanoindentation using atomic force microscopy clearly showed that Young's moduli of the photocured polymer films decreased with increasing hydrolysis time. Their potential biomedical applications are discussed.

    DOI: 10.1021/bm034231k

  • Competition between compaction of single chains and bundling of multiple chains in giant DNA molecules Reviewed

    T Iwataki, S Kidoaki, T Sakaue, K Yoshikawa, SS Abramchuk

    JOURNAL OF CHEMICAL PHYSICS   120 ( 8 )   4004 - 4011   2004.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    It has been established that in a dilute solution individual giant DNA molecules undergo a large discrete transition between an elongated coil state and a folded compact state. On the other hand, in concentrated solutions, DNA molecules assemble into various characteristic states, including multichain aggregate, liquid crystalline, ionic crystal, etc. In this study, we compared single-chain and multiple-chain events by observing individual chains using fluorescence microscopy. We used spermidine, SPD(3+), as a condensing agent for giant DNA. When the concentration of DNA is below 1 muM in base-pair units, individual DNA molecules exhibit a transition from an elongated state to a compact state. When the concentration of DNA is increased to 10 muM, a thick fiberlike assembly of multiple chains appears. AFM measurements of this thick fiber revealed that more than tens of DNA molecules form a bundle structure with parallel ordering of the chains. The transition between single-chain compaction and bundle formation with multiple-chain assemblies was reproduced by a theoretical calculation. (C) 2004 American Institute of Physics.

    DOI: 10.1063/1.1642610

  • Substrate-dependent cellular behavior of Swiss 3T3 fibroblasts and activation of Rho family during adhesion and spreading processes. Reviewed

    Kato S, Kidoaki S, Matsuda T

    Journal of biomedical materials research. Part A   68 ( 2 )   314 - 324   2004.2

     More details

    Language:Others  

    Substrate-dependent cellular behavior of Swiss 3T3 fibroblasts and activation of Rho family during adhesion and spreading processes.

    DOI: 10.1002/jbm.a.20012

  • Physicochemical properties and bio-degradation of segmented polyurethane and poly(urethane-urea) derived from lysine-based diisocyanate Reviewed International journal

    T. Yamaguchi, H. Otsuka, S. Kidoaki, T. Matsuda, A. Takahara

    Trans. Mater. Res. Soc. Japan   2004.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Thermoresponsive structural change of a poly(N-isopropylacrylamide) graft layer measured with an atomic force microscope Reviewed

    S Kidoaki, S Ohya, Y Nakayama, T Matsuda

    LANGMUIR   17 ( 8 )   2402 - 2407   2001.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To directly characterize the thermoresponsive structural changes of a poly(N-isopropylacrylamide) (PNIPAAm) graft layer at the microscopic level, the force-distance curve (f-d curve) was measured on a well-tailored end-grafted PNIPAAm surface in aqueous solution at 25 and 40 degreesC, using an atomic force microscope (AFM). The PNIPAAm surface was prepared by an iniferter-based photograft polymerization technique. The approach trace of the f-d curve exhibited a steric repulsion profile at 25 degreesC, while the range of repulsion decreased 1/10 to 1/20 at 40 degreesC, confirming the ascending-heat induced collapse of the PNIPAAm graft layer. The change in thickness of the graft layer was complementarily measured from the scanning images of the boundary between the grafted and nongrafted regions under well-defined scanning forces. The thermoresponsive characteristics of the PNIPAAm graft layer including its interaction with proteins and the applied-load dependence of the measured graft thickness are discussed.

  • Measurement of the interaction forces between proteins and iniferter-based graft-polymerized surfaces with an atomic force microscope in aqueous media Reviewed

    S Kidoaki, Y Nakayama, T Matsuda

    LANGMUIR   17 ( 4 )   1080 - 1087   2001.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    To investigate the characteristics of interaction forces between proteins and end-grafted polymer surfaces, force-versus-distance curves (f-d curves) were measured between protein-fixed probe tips (albumin (Alb) and lysozyme (Lyso)) and surfaces graft-polymerized with N,N-dimethylacrylamide (DMAAm) or acrylic acid (AAc) in an aqueous solution, using an atomic force microscope. DMAAm graft-polymerized surfaces with different chain lengths and AAc graft-polymerized surface were prepared by photopolymerization on a dithiocarbamate (iniferter)-immobilized surface. The effects of grafted chain length, grafting density, and electrostatic property of the grafted chain segments on the interaction forces in the processes of protein adsorption onto and desorption from the graft-polymerized surfaces were analyzed from the approaching and retracting traces of the observed f-d curves, respectively. (1) In the Alb/poly(DMAAm) system, steric repulsion was observed, in which the interaction range and the compressive force of the poly(DMAAm) layer linearly increased with increasing chain length of poly(DMAAm) except for very short chain lengths. Adhesion force was observed only for the poly(DMAAm) layer with short chains. (2) In the Alb/poly(AAc) system, repulsive force due to steric and electrostatic interactions, and "tooth-like" adhesion forces were observed. (3) In the Lyso/poly(AAc) system, electrostatic attraction and adhesion forces were observed. From observation 1, the grafting density, the elastic modulus of the poly(DMAAm) layer, and the conformation of the grafted chain ("mushroom" or "brush") were deduced and are discussed in relation to the characteristics of the interaction force with the proteins. From observations 2 and 3, it was found that a polyanionic surface can provide a significant adhesion force not only to positively charged proteins but also to negatively charged ones at physiological pH.

    DOI: 10.1021/la000003p

  • Temperature-directed compaction of single DNA molecule grafted with poly(N-isopropylacrylamide) International journal

    D. Umeno, M. Maeda, S. Kidoaki, and K. Yoshikawa

    Nucleic Acids Res. Symp. Ser.   1998.1

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • 長鎖DNAの構造をみる

    木戸秋 悟, 吉川 研一

    高分子   46 ( 4 )   252 - 254   1997.4

     More details

    Language:Japanese  

    Application of Fluorescence Microscopy for the Single Molecular Observation of Giant Duplex DNA Chain

    DOI: 10.1295/kobunshi.46.252

  • Controlling the Folding Transition of Giant DNA: Cooperative Effect Between Neutral Polymer and Basic polypeptide International journal

    S. Kidoaki and K. Yoshikawa

    Nucleic Acids Res. Symp. Ser   1996.1

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • Solution Properties of Fibrous Chains Constructed of Amphiphilic Molecules Reviewed International journal

    T. Imae and S. Kidoaki

    J. Jpn. Oil Chem. Soc. (YUKAGAKU)   1995.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The Multistability Observed on the Condensed Structure of DNA/Cationic Polypeptide Complex International journal

    S. Kidoaki and K. Yoshikawa

    Nucleic Acids Res. Symp. Ser   1994.1

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

▼display all

Books

  • Manipulation of durotaxis on a matrix with cell-scale stiffness heterogeneity

    S. Kidoaki(Role:Joint author)

    Royal Society of Chemistry  2022.8 

     More details

    Language:English   Book type:Scholarly book

  • “メカノバイオミメティックスによる細胞操作工学” 『CSJ Current Review 28:持続可能性社会を拓くバイオミメティックス』(第13章)

    木戸秋 悟(Role:Joint author)

    化学同人  2018.3 

     More details

    Language:Japanese   Book type:General book, introductory book for general audience

  • “メカノバイオマテリアル” 別冊・医学のあゆみ, 「メカノバイオロジーからメカノメディシンへ」(編集:曽我部正博)

    木戸秋 悟(Role:Joint author)

    医歯薬出版  2017.5 

     More details

    Responsible for pages:153-157   Language:Japanese   Book type:Scholarly book

  • “基材硬さと細胞の関係” 『細胞培養の基礎知識と細胞培養基材の利用・開発の留意点』(第9章第3節)

    木戸秋 悟(Role:Joint author)

    情報機構,  2016.10 

     More details

    Language:Japanese   Book type:Scholarly book

  • “幹細胞分化をコントロールする力学場” 下村 正嗣 編著『トコトンやさしいバイオミメティックスの本』(第4章42)

    木戸秋 悟(Role:Joint author)

    日刊工業新聞社  2016.8 

     More details

    Language:Japanese   Book type:General book, introductory book for general audience

  • “再生医工学におけるメカノバイオロジーII:創傷治癒/基質高度検知/基質工学” 曽我部 正博 編集『メカノバイオロジー:細胞が力を感じ応答する仕組み』(第22章)

    木戸秋 悟, 小林 剛(Role:Joint author)

    化学同人  2015.7 

     More details

    Language:Japanese   Book type:General book, introductory book for general audience

  • "Mechanobio-materials: Design of elastically-micropatterned hydrogels to manipulate cell mechanotaxis and motility-coupled functions" in "Recent Advances in Mechanobiology"

    Satoru Kidoaki(Role:Joint author)

    The Shanghai Scientific and Technological Literature Publishing House  2012.11 

     More details

    Language:English   Book type:Scholarly book

  • "Fabrication of elasticity-tunable gelatinous gel for MSC culture" : Methods and Protocols, Second Edition, Methods Molecular Biology, Vol. 1416, Massimiliano Gnecchi (Eds): Mesenchymal Stem Cells, 978-1-4939-3582-6, 317547_2_En, (25) (Springer Volume)

    Thasaneeya Kuboki, Satoru Kidoaki(Role:Joint author)

    2015.12 

     More details

    Responsible for pages:in press   Language:English   Book type:Scholarly book

  • 石原一彦、塙隆夫、前田瑞夫編集『バイオマテリアルの基礎』 第4章3 ”細胞の挙動を操作する微視的培養力学場の設計”

    木戸秋 悟(Role:Joint author)

    日本医学館  2010.3 

     More details

    Language:Japanese   Book type:Scholarly book

  • 丸山厚監訳『ナノバイオテクノロジー〜未来を拓く概念と応用〜』 第10章 バイオ分析と診断のためのカンチレバーアレイセンサー 第11章 剪断力制御走査型イオン伝導顕微鏡

    木戸秋 悟(Role:Joint translator)

    (株)エヌ・ティー・エス  2008.11 

     More details

    Language:Japanese   Book type:Scholarly book

  • 秋吉一成、岸田昌夫監修『次世代医療のための高分子材料工学』 第4章3 ”微視的材料力学場設計による細胞機能のベクトル操作”

    木戸秋 悟(Role:Joint author)

    シーエムシー出版  2008.3 

     More details

    Language:Japanese   Book type:Scholarly book

  • 本宮達也監修 "ファイバー" スーパーバイオミメティックスー近未来テクノロジー 第2章3節8 "電界紡糸法による組織工学用細胞外マトリックス・骨格・デバイスの開発"

    木戸秋 悟、松田 武久(Role:Joint author)

    (株)エヌ・ティー・エス  2006.9 

     More details

    Language:Japanese   Book type:Scholarly book

  • DNAの折り畳み〜高次構造と機能

    吉川研一・山崎裕一・水野彰・松澤有希子・木戸秋悟・高木清二・野口博司・小山義之・恵美宣彦・安部明弘(Role:Joint author)

    アイピーシー  2003.1 

     More details

    Responsible for pages:第2章5節  "PEGによるDNA折り畳みの理論" 第4章  "DNAとカチオンの相互作用II:巨大DNAのコンフォメーション・アッセイによる解析"   Language:Japanese   Book type:Scholarly book

▼display all

Presentations

  • Efficient Protein Modification and Enhanced Cell Adhesion on Primary Amine-Containing PAAm Gels International conference

    Sayaka Masaike, Satoru Kidoaki

    MRM2023/IUMRS-ICA2023  2023.12 

     More details

    Event date: 2023.12

    Language:English  

    Venue:京都国際会議場、京都   Country:Japan  

  • 細胞が細胞を包むしくみ:血管内皮細胞と周皮細胞の場合

    杉原 圭, 佐々木 沙織, 木戸秋 悟, 植村 明嘉, 三浦 岳

    第96回日本生化学会大会  2023.10 

     More details

    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場、福岡   Country:Japan  

  • Elucidation of substrate stiffness mediated rejuvenation mechanism of aging stem cells through the regulation of cellular homeostasis

    Thasaneeya Kuboki, Satoru Kidoaki

    第96回日本生化学会大会  2023.10 

     More details

    Event date: 2023.10 - 2023.11

    Language:English  

    Venue:福岡国際会議場   Country:Japan  

  • 非一様力学場がもたらす運動細胞の長周期ゆらぎ増幅 Invited

    木戸秋悟

    第74回コロイド界面化学討論会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:信州大学、長野   Country:Japan  

  • 非一様力学場運動による間葉系幹細胞の長周期ゆらぎ調節と治療有効性増強効果 Invited

    木戸秋悟

    化学工学会第54回秋季大会  2023.9 

     More details

    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡大学、 福岡市   Country:Japan  

  • Mechanobiological design of a postoperative-placing matrix for selective capture and elimination of residual cancer cells Invited International conference

    Satoru Kidoaki

    PRESM2023  2023.7 

     More details

    Event date: 2023.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:万国津梁館、沖縄   Country:Japan  

  • Therapeutic potential of mechano-activated mesenchymal stem cells migrating on a matrix with cell-scale stiffness heterogeneity Invited International conference

    Satoru Kidoaki

    STEM CELLS & GENERATIVE MEDICINE- FROM BENCH TO BEDSIDE  2023.6 

     More details

    Event date: 2023.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 高分子薄膜力学場における細胞モーション解析

    廣岡穂菜美、政池彩雅、木戸秋悟

    第35回バイオエンジアリング講演会  2023.6 

     More details

    Event date: 2023.6

    Language:Japanese  

    Venue:日立システムズホール仙台   Country:Japan  

  • 細胞−基材接着界面の局所pH分布の可視化

    政池彩雅、木戸秋悟

    第35回バイオエンジニアリング講演会  2023.6 

     More details

    Event date: 2023.6

    Language:Japanese  

    Venue:日立システムズホール仙台   Country:Japan  

  • Therapeutic potential of regulation of long-period fluctuations in mesenchymal stem cells migrating on a matrix with cell-scale stiffness heterogeneity International conference

    Satoru Kidoaki

    International Symposium on Mechanobiology for Human Health  2023.3 

     More details

    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 非一様力学場がもたらす運動細胞のメカノ活性化 Invited

    木戸秋 悟

    第34回バイオエンジニアング講演会  2022.6 

     More details

    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Understanding the mecahno-regulation of substrate stiffness on rejuvenation mechanism of aging stem cell International conference

    Thasaneeya Kuboki, Satoru Kidoaki

    9th World Congress of Biomechanics  2022.7 

     More details

    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Online   Country:Japan  

  • Heterogeneity of RUNX2 localization response to stiffness of culture substrate in human mesenchymal stem cells International conference

    Masashi Yamazaki, Satoru Kidoaki, Hiromi Miyoshi

    9th World Congress of Biomechanics  2022.7 

     More details

    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Online   Country:Japan  

  • 形態揺らぎ増幅細胞におけるクロマチン動態解析

    立木 旭、木戸秋 悟

    第 73 回コロイドおよび界面化学討論会  2022.9 

     More details

    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Understanding the mecahno-regulation of substrate stiffness on rejuvenation mechanism of aging stem cell International conference

    Thasaneeya Kuboki, Satoru Kidoaki

    The Japan Society of Mechanical Engineers ICM&P 2022 International Conference on Materials & Processing 2022  2022.11 

     More details

    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Online   Country:Japan  

  • Understanding the mecahno-regulation of substrate stiffness on rejuvenation mechanism of aging stem cells International conference

    Thasaneeya Kuboki, Satoru Kidoaki

    MBSJ2022  2022.11 

     More details

    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 階層的粘弾性制御を可能とするセグメント化ゲルファイバーマトリックスの構築

    矢津 秀和、木戸秋 悟

    メカノバイオ討論会  2022.12 

     More details

    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 形態揺らぎ増幅細胞におけるクロマチン動態解析

    立木 旭、木戸秋 悟

    第 40 回染色体ワークショップ 第 21 回核ダイナミクス研究会  2022.12 

     More details

    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Manipulation of cellular duroraxis on a matrix with cell-scale stiffness-heterogeneity Invited International conference

    Satoru Kidoaki

    Engineering Mechanics of Cell&Tissue Morphogenesis  2022.6 

     More details

    Event date: 2022.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 非一様力学場・非定住培養による核活性化・治療効果増強間葉系幹細胞の創出 Invited

    木戸秋 悟

    第21回再生医療学会総会  2022.3 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • オルガノイド安定形成を導く足場粘弾性最適条件の設計

    岩下 皇藏、木戸秋 悟

    生物物理学会メカノバイオサブグループ研究会  2021.12 

     More details

    Event date: 2021.12

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 接着斑クラッチ分子集合体へのマトリックス変形性効果

    政池 彩雅、 木戸秋 悟

    生物物理学会メカノバイオサブグループ研究会  2021.12 

     More details

    Event date: 2021.12

    Language:Japanese  

    Venue:オンライン   Country:Japan  

  • 細胞接着形態制御のための疎水性凝縮ポリマー表面の水平変形特性解析

    政池 彩雅, 木戸秋 悟

    2021年度 機械学会年次大会  2021.9 

     More details

    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 階層的マイクロファイバーゲルの弾性最適化によるがん細胞補足マトリックスの構築

    木戸秋 悟・黄 道翔

    第70回高分子討論会  2021.9 

     More details

    Event date: 2021.9 - 2021.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 細胞内部応力のゆらぎ増幅の持つ機能について

    木戸秋 悟

    生物物理学会メカノバイオサブグループ研究会  2021.9 

     More details

    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Adhesive-ligand-independent cell shaping controlled by the lateral deformability of condensed polymer matrix International conference

    Sayaka Masaike, Satoru Kidoaki

    MBI 3M 2021  2021.7 

     More details

    Event date: 2021.7

    Language:English  

    Venue:オンライン   Country:Japan  

  • Nuclear activation by avoiding tensional equilibrium in the cells migrating on matrix with stiffness-heterogeneity Invited International conference

    Satoru Kidoaki , Hiroyuki Ebata, Kousuke Moriyama, Thasaneeya Kuboki, Yukie Tsuji, Rumi Sawada, Misaki kaneshiro, Kazusa Tanaka, Ken Kono

    RIMS Mechanobiology Symposium  2021.7 

     More details

    Event date: 2021.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 細胞核の応力増幅培養による間葉系幹細胞の活性化 Invited

    木戸秋 悟 , 江端 宏之, 久保木 タッサニーヤー, 金城 美咲 , 澤田 留美,辻 ゆきえ, 田中 和沙, 河野 健, 草川森士

    2021バイオエンジニアリング講演会  2021.6 

     More details

    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • マトリックスメカノバイオロジー Invited

    木戸秋 悟

    RIMS Tutorial Seminar 生物の創るパターンとダイナミクス:基礎からの展開  2021.6 

     More details

    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 非一様弾性場・非定住培養における細胞内張力揺らぎ増強効果

    江端 宏之、木戸秋 悟

    第60回生体医工学会大会  2021.6 

     More details

    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • ヘテロ力学場非定住運動がもたらす細胞核クロマチンの空間ゆらぎ増幅

    木戸秋 悟 , 江端 宏之, 森山 幸祐, 久保木 タッサニーヤー, 辻 ゆきえ, 澤田 留美, 金城 美咲, 立木 旭, 田中 和沙, 河野 健

    2021年メカノバイオロジー学会年会  2021.3 

     More details

    Event date: 2021.3 - 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 非一様弾性場上の細胞運動における細胞核形状のダイナミクス

    江端 宏之, 久保木タッサニーヤー, 木戸秋 悟

    物理学会第76回年次大会  2021.3 

     More details

    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Mechano-activation of mesenchymal stem cells by avoiding intracellular tensional equilibrium on matrix with stiffness-heterogenity International conference

    Satoru Kidoaki, Hiroyuki Ebata1, Kousuke Moriyama, Thasaneeya Kuboki, Yukie Tsuji, Rumi Sawada, Ken Kono, Kazusa Tanaka

    65th Biophysical Society Annual Meeting, 2021  2021.2 

     More details

    Event date: 2021.2

    Language:English  

    Venue:オンライン   Country:United States  

  • 細胞核の応力増幅培養による間葉系幹細胞のメカノ活性化 Invited

    木戸秋 悟

    バイオマテリアル学会九州支部大会  2021.1 

     More details

    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • オルガノイド安定形成を誘導するマトリゲル粘弾性条件の特定

    岩下皇藏、江端宏之、辻ゆきえ、木戸秋悟

    第32回高分子ゲル研究討論会  2021.1 

     More details

    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 幹細胞の形態振動を誘導するポリマーパターニング培養基材の開発

    梶原 晃、木戸秋 悟

    第32回高分子ゲル研究討論会  2021.1 

     More details

    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Functional activations by avoiding tensional equilibrium in the cells migrating on matrix with stiffness-heterogeneity Invited International conference

    Satoru Kidoaki , Hiroyuki Ebata, Kousuke Moriyama, Thasaneeya Kuboki, Yukie Tsuji, Rumi Sawada, Misaki kaneshiro, Kazusa Tanaka, Ken Kono

    MBSJ2020  2020.12 

     More details

    Event date: 2020.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 間葉系幹細胞のメカノ活性化を誘導する細胞核の力学動態解析

    木戸秋 悟、江端 宏之、久保木 タッサニーヤー、澤田 留美、辻 ゆきえ、金城 美咲、田中 和沙、河野 健

    第69回高分子討論会  2020.9 

     More details

    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  • 細胞核の応力増幅培養基材による幹細胞活性化 Invited

    木戸秋 悟

    第10回ナノカーボンバイオシンポジウム  2020.9 

     More details

    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  • 非一様弾性場における細胞の長時間牽引力ダイナミクス

    江端 宏之, 木戸秋 悟

    日本物理学会2020秋季年会  2020.9 

     More details

    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  • 細胞核の応力増幅培養による間葉系幹細胞の活性化 Invited

    木戸秋 悟

    第72回生物工学会大会  2020.9 

     More details

    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  • 管状足場における間葉系幹細胞の曲率依存的動態の解析

    藤田 彩乃、木戸秋 悟

    第59回日本生体医工学会大会  2020.5 

     More details

    Event date: 2020.5

    Language:Japanese  

    Venue:web開催   Country:Japan  

  • オルガノイド形成のための足場界面ミクロレオロジーの解析

    岩下 皇蔵、江端 宏之、藤田 彩乃、辻 ゆきえ、木戸秋 悟

    第59回日本生体医工学会大会  2020.5 

     More details

    Event date: 2020.5

    Language:Japanese  

    Venue:web開催   Country:Japan  

  • 非一様弾性場・非定住遊走による間葉系幹細胞のエクササイズ培養:機構と効果 Invited

    木戸秋 悟、江端 宏之、久保木 タッサニーヤー、金城 美咲、澤田 留美、辻 ゆきえ、田中 和紗、河野 健、草川 森士

    第59回日本生体医工学会大会  2020.5 

     More details

    Event date: 2020.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  • 間葉系幹細胞のRUNX2とYAPの局在を決定する基板の弾性率閾値

    山崎 雅史、木戸秋 悟、藤江 裕道、三好 洋美

    第32回バイオエンジニアリング講演会  2019.12 

     More details

    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 細胞形態振動を誘起する接着海面の垂直/水平変形特性の動的制御

    政池 彩雅、木戸秋 悟

    第32回バイオエンジニアリング講演会  2019.12 

     More details

    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 弾性パターニングゲル作製技術の実際問題

    木戸秋 悟

    第二回メカノ分科会  2019.12 

     More details

    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪大学   Country:Japan  

  • Traction force dynamics of mesenchymal stem cells on micro-elastically patterned hydrogels International conference

    Hiroyuki Ebata, Satoru Kidoaki

    2nd G'L'owing Polymer Symposium in KANTO  2019.11 

     More details

    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:東京理科大学   Country:Japan  

  • 微視的培養力学場設計に基づく細胞操作技術

    木戸秋 悟

    日本動物実験代替法学会 第32回大会  2019.11 

     More details

    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  • Stiffness-optimized drug-loaded matrix for selective capture and elimination of cancer cells International conference

    Daoxiang Huang, Satoru Kidoaki

    Post-A3 meeting China-Japan Biopolymer Symposium at Hibikino  2019.11 

     More details

    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  • Heterogeneous field of matrix elasticity to exercise mesenchymal stem cells through their nomadic migrations Invited International conference

    Satoru Kidoaki

    Okinawa Colloids 2019  2019.11 

     More details

    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Okinawa   Country:Japan  

  • Computational modeling and experiments of cell wrapping: dissecting the mechanisms of endothelial cell coverage by pericytes

    Kei Sugihara, Saori Sasaki, Akiyoshi Uemura, Satoru Kidoaki, and Takashi Miura

    The 20th International Conference on System Biology  2019.11 

     More details

    Event date: 2019.11

    Language:English  

    Venue:Okinawa   Country:Japan  

  • Exercising mesenchymal stem cells through nomadic culture on heterogeneous field of matrix elasticity International conference

    Satoru Kidoaki, Kouske Moriyama, Thasaneeya Kuboki, Rumi Sawada, Yukie Tsuji, Hiroyuki Ebata, Saori Sasaki, Aya Yamamoto, Ken Kono, Kazusa Tanaka

    Cell Physics 2019  2019.10 

     More details

    Event date: 2019.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:ザールラント大学   Country:Germany  

  • 非一様弾性場・非定住遊走による間葉系幹細胞のエクササイズ培養

    木戸秋 悟、森山 幸祐、久保木 タッサニーヤー、澤田 留美、辻 ゆきえ、江端 宏之、佐々木 沙織、山本 安希、田中 和沙、河野 健

    第68回高分子討論会  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井大学   Country:Japan  

  • Evaluation of cell mechanotransduction regulation via matrix with lateral deformation characteristics

    政池彩雅、木戸秋悟

    第57回日本生物物理学会年会  2019.9 

     More details

    Event date: 2019.9

    Language:English  

    Venue:宮崎   Country:Japan  

  • iPS cells show mechanotactic accumulation, enhanced proliferation and higher expression of stemness marker in optimal region of matrix elasticity

    王 夢繁、木戸秋悟

    第57回日本生物物理学会年会  2019.9 

     More details

    Event date: 2019.9

    Language:English  

    Venue:宮崎   Country:Japan  

  • Homing and mechano-response of Muse cells analyzed on S1P-modified hydrogel with tunable elasticity

    郭蕾、木戸秋悟

    第57回日本生物物理学会年会  2019.9 

     More details

    Event date: 2019.9

    Language:English  

    Venue:宮崎   Country:Japan  

  • Investigation of upstream regulatory factors of APC expression in the MSCs in frustrated differentiation

    金城美咲、木戸秋悟

    第57回日本生物物理学会年会  2019.9 

     More details

    Event date: 2019.9

    Language:English  

    Venue:宮崎   Country:Japan  

  • 細胞被覆の計算論的モデルと実験:内皮細胞被覆におけるペリサイト-細胞外基質間接着の重要性

    杉原圭,佐々木沙織,植村明嘉,木戸秋悟,三浦岳

    2019年度日本数理生物学会年会  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京工業大学   Country:Japan  

  • 弾性パターニング場におけるドメインサイズ依存的な硬領域指向性細胞運動

    江端 宏之, 森山幸祐, 久保木タッサニーヤー, 木戸秋 悟

    日本物理学会2019秋季大会  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜大学   Country:Japan  

  • 非一様力学場・非定住運動によるエクササイズ細胞培養の科学と応用

    木戸秋 悟

    21世紀を明るく科学する会2019  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:天城   Country:Japan  

  • 細胞スケール不均一弾性場におけるデュロタクシスの一般挙動 Invited

    江端宏之、森山幸祐、久保木タッサニーヤー、木戸秋悟

    第一回メカノバイオロジー研究会2019  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:香川研直島   Country:Japan  

  • 幹細胞の品質保持培養のためのメカノバイオマテリアルの開発

    木戸秋 悟

    令和元年度 AMED 再生医療研究交流会  2019.9 

     More details

    Event date: 2019.9

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 細胞培養ハイドロゲル表面リンクルの精密マルチスケール制御

    佐々木 沙織,木戸秋悟

    日本機械学会 第 30 回バイオフロンティア講演会  2019.7 

     More details

    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • 分化フラストレートMSCにおけるAPC発現調節の上流機構の検証

    金城 美咲、久保木タッサニーヤー、木戸秋 悟

    第56回化学関連支部合同九州大会  2019.7 

     More details

    Event date: 2019.7

    Language:Japanese  

    Country:Japan  

  • S1P修飾ハイドロゲルを用いたMuse細胞ホーミング及び力学場応答性の解析

    郭 蕾、辻ゆきえ、木戸秋 悟

    第56回化学関連支部合同九州大会  2019.7 

     More details

    Event date: 2019.7

    Language:Japanese  

    Country:Japan  

  • Development of an evaluation system that can predict the osteogenic potential of human mesenchymal stem cells easily and promptly International conference

    Rumi Sawada, Ken Kono, Kazusa Tanaka, Yoji Sato, Satoru Kidoaki

    2019 Annual Meeting of International Society for Stem Cell Research  2019.6 

     More details

    Event date: 2019.6

    Language:English  

    Venue:Los Angeles Convention Center   Country:United States  

  • 非一様弾性場・非定住培養における間葉系幹細胞のAPC発現制御

    木戸秋 悟、江端 宏之、森山 幸祐、久保木 タッサニーヤー、澤田 留美、辻 ゆきえ、佐々木 沙織、山本 安希、田中 和紗、河野 健

    第71回日本細胞生物学会年会  2019.6 

     More details

    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場   Country:Japan  

  • 非一様弾性場・非定住培養における間葉系幹細胞のAPC発現調節

    木戸秋 悟、森山 幸祐、久保木 タッサニーヤー, 辻 ゆきえ、江端 宏之、佐々木 沙織、山本 安希, 澤田 留美、田中 和紗、河野 健

    第57回日本生体医工学会年会  2019.6 

     More details

    Event date: 2019.6 - 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • Pericyte morphogenesis: endothelial cell wrapping and preference for vascular branching

    Kei Sugihara, Saori Sasaki, Akiyoshi Uemura, Satoru Kidoaki, and Takashi Miura

    第52回日本発生生物学会年会  2019.5 

     More details

    Event date: 2019.5

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • ヒト間葉系幹細胞の骨分化能を簡便かつ早期に予測できる評価系の開発

    澤田留美, 田中和沙, 河野 健, 佐藤陽治, 木戸秋悟

    第18回再生医療学会総会  2019.3 

     More details

    Event date: 2019.3

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 非一様弾性場・非定住培養による間葉系幹細胞の品質保持

    森山 幸祐,久保木 タッサニーヤー,澤田 留美,辻 ゆきえ,江端 宏之,佐々木 沙織,山本 安希,田中 和沙,河野 健,木戸秋 悟

    化学工学会第84回年会  2019.3 

     More details

    Event date: 2019.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Exercising mesenchymal stem cells through nomadic culture on heterogeneous field of matrix elasticity Invited International conference

    S. Kidoaki

    Kyoto Winter School“Quantifying Dynamics of Life”  2019.3 

     More details

    Event date: 2019.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 間葉系幹細胞未分化保持のための細胞接着形態振動培養基材の設計

    政池彩雅, 木戸秋悟

    2018年日本生体医工学会九州支部学術講演会  2019.3 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 間葉系幹細胞の温度振動培養

    政池彩雅, 木戸秋悟

    第9回定量生物の会  2019.1 

     More details

    Event date: 2019.1

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • Cell-type dependent durotaxis on micro-elastically heterogeneous gels

    H. Ebata, K. Moriyama, T. Kuboki, S. Kidoaki

    アクティブマター研究会2019  2019.1 

     More details

    Event date: 2019.1

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Precise multi-scaled control of surface wrinkle on the hydrogels

    S. Sasaki and S. Kidoaki

    MRS-J 2018年会  2018.12 

     More details

    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  • Modulation of APC expression in mesenchymal stem cell during nomadic culture on heterogeneous field of elasticity International conference

    S. Kidoaki, K. Moriyamaa, T. Kuboki, R. Sawada, Y. Tsuji, H. Ebata, S. Sasaki, A. Yamamoto, K. Kono, K. Tanaka

    ABA-ASA2018  2018.12 

     More details

    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Melbourne   Country:Australia  

  • ペリサイトによる形態形成:数理モデルと実験の融合によるアプローチ

    杉原圭, 佐々木沙織, 植村明嘉, 木戸秋悟, 三浦岳

    第41回日本分子生物学会年会  2018.11 

     More details

    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • Domain-size dependent cellular durotaxison micro-elastically stripe patterned gels International conference

    H. Ebata, K. Moriyama, T. Kuboki, S. Kidoaki

    APEF2018  2018.11 

     More details

    Event date: 2018.11

    Language:English  

    Venue:東京   Country:Japan  

  • 非一様弾性場・非定住培養による間葉系幹細胞の品質保持

    森山 幸祐,久保木 タッサニーヤー,澤田 留美,辻 ゆきえ,江端 宏之,佐々木 沙織,山本 安希,田中 和沙,河野 健,木戸秋 悟

    第40回日本バイオマテリアル学会大会  2018.11 

     More details

    Event date: 2018.11

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 弾性パターニング場の空間周期変調による硬領域指向性細胞運動の制御

    江端 宏之,森山 幸祐,久保木 タッサニーヤー,木戸秋 悟

    第29回バイオフロンティア講演会  2018.10 

     More details

    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 幹細胞のメカノバイオロジー Invited

    木戸秋 悟

    第8回CSJ化学フェスタ2018  2018.10 

     More details

    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • iPS細胞は最適弾性率を持つハイドロゲル表面に移動し増殖する

    王夢繁, 木戸秋悟

    第56回日本生物物理学会年会  2018.9 

     More details

    Event date: 2018.9

    Language:Japanese  

    Venue:岡山   Country:Japan  

  • 間葉系幹細胞の温度依存形態振動に伴うメカノシグナル転換因子の核-細胞質シャトリング

    政池彩雅, 木戸秋悟

    第56回日本生物物理学会年会  2019.9 

     More details

    Event date: 2018.9

    Language:Japanese  

    Venue:岡山   Country:Japan  

  • 非一様弾性場・非定住培養における間葉系幹細胞のAPC 発現調節

    木戸秋 悟, 森山 幸祐, 久保木 タッサニーヤー, 澤田 留美, 辻 ゆきえ, 江端 宏之, 佐々木 沙織, 山本 安希, 田中 和沙, 河野 健

    第67回高分子討論会  2018.9 

     More details

    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • Comprehensive gene expression analysis of human mesenchymal stem cells cultured on the micro elastically triangle patterned gel matrix International conference

    R. Sawada, K. Moriyama, K. Tanaka, K. Kono, Y. Sato, H. Ebata, S. Sasaki, T. Kuboki

    TERMIS2018  2018.9 

     More details

    Event date: 2018.9

    Language:English  

    Venue:京都   Country:Japan  

  • Elasticity threshold of the gel matrix to manipulate migration and differentiation of mesenchymal stem cell International conference

    K. Moriyama, S. Kidoaki

    PhysCell2018  2018.9 

     More details

    Event date: 2018.9

    Language:English  

    Venue:Harrogate   Country:United Kingdom  

  • Modulation of APC expression in mesenchymal stem cell during nomadic culture on heterogeneous field of elasticity International conference

    S. Kidoaki, K. Moriyama, T. Kuboki, R. Sawada, Y. Tsuji, H. Ebata, S. Sasaki, A. Yamamoto, K. Kono, K. Tanaka

    PhysCell2018  2018.9 

     More details

    Event date: 2018.9

    Language:English  

    Venue:Harrogate   Country:United Kingdom  

  • Migration model of crawling cells driven by persistent fluctuation of cell shape International conference

    H. Ebata, A. Yamamoto, Y. Tsuji, S. Sasaki, K. Moriyama, T. Kuboki, S. Kidoaki

    PhysCell2018  2018.9 

     More details

    Event date: 2018.9

    Language:English  

    Venue:Harrogate   Country:United Kingdom  

  • Mechanobio-materials manipulating motility and functions of stem cells Invited

    S. Kidoaki

    OISTセミナー  2018.7 

     More details

    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • Investigation of marker genes predicting osteogenic differentiation potential of human mesenchymal stem cells International conference

    R. Sawada, K. Kono, K. Tanaka, Y. Sato, S. Kidoaki

    ISSCR2018  2018.6 

     More details

    Event date: 2018.6

    Language:English  

    Venue:メルボルン   Country:Australia  

  • Pericyte coverage of endothelial cells: in vitro experiments and computational modeling

    K. Sugihara, S. Sasaki, A. Uemura, S. Kidoaki , T. Miura

    2018発生生物学会  2018.6 

     More details

    Event date: 2018.6 - 2019.5

    Language:Japanese  

    Venue:東京   Country:Japan  

  • ヒト間葉系幹細胞の骨分化能を予測するマーカー遺伝子の探索

    澤田留美、田中和沙、河野 健、佐藤陽治、木戸秋悟

    第17回日本再生医療学会総会  2018.3 

     More details

    Event date: 2018.3

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • Frustrated differentiation of mesenchymal stem cells induced by nomadic movement between stiff and soft region of hydrogel matrix Invited International conference

    Satoru Kidoaki

    2018 IMCE International Symposium  2018.3 

     More details

    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 非一様弾性場・非定住培養における間葉系幹細胞のAPC発現調節

    木戸秋 悟

    第3回日本メカノバイオロジー学会  2018.3 

     More details

    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学   Country:Japan  

  • メカノシグナル入力を動的に制御する細胞運動操作ゲル基材の設計

    森山 幸祐, 久保木 タッサニーヤー, 木戸秋 悟

    化学工学会第83年会  2018.3 

     More details

    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 間葉系幹細胞の接着形態振動培養

    #政池彩雅,  木戸秋悟

    2018年日本生体医工学会九州支部学術講演会  2018.3 

     More details

    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  • 幹細胞の品質保持・操作に関わるメカノバイオロジー Invited

    木戸秋 悟

    京都リサーチパーク 再生医療の全体像を見わたせる分かりやすい解説講座  2018.1 

     More details

    Event date: 2018.1

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • Development of Cellulose Nanofiber-Based Dispersion Culture System for Mesenchymal Stem Cell Keeping Highly-Qualified Stemness International conference

    Midori Toratani, Yukie Tuji, Hisato Hayashi, Takehisa Iwama, Masato Horikawa, and Satoru Kidoaki

    2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers(18th) and Fibers(16th)  2017.12 

     More details

    Event date: 2017.12

    Language:English  

    Venue:北九州   Country:Japan  

  • Fabrication of a micro fibrous gel matrix with tunable elasticity for selectively- capturing cancer cells International conference

    Daoxiang Huang, Satoru Kidoaki

    2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers(18th) and Fibers(16th)  2017.12 

     More details

    Event date: 2017.12

    Language:English  

    Venue:北九州   Country:Japan  

  • Development of photo-cross-linked collagen gels keeping the native triple helix International conference

    Takahiro Fujisawa, and Satoru Kidoaki

    2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers(18th) and Fibers(16th)  2017.12 

     More details

    Event date: 2017.12

    Language:English  

    Venue:北九州   Country:Japan  

  • 非一様弾性基材上での細胞牽引力顕微解析法の開発

    江端 宏之, @濱野 浩佑, 木戸秋 悟

    日本機械学会 第30回バイオエンジニアリング講演会  2017.12 

     More details

    Event date: 2017.12

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 細胞メカノバイオロジーを操作する微視的培養力学場設計 Invited

    木戸秋 悟

    日本機械学会 第30回バイオエンジニアリング講演会  2017.12 

     More details

    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Frustrated differentiation of mesenchymal stem cells induced by normadic migration between stiff and soft region of hydrogel matrix International conference

    Satoru Kidoaki

    ISMB2017  2017.12 

     More details

    Event date: 2017.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Singapore   Country:Japan  

  • 非一様弾性場における細胞接着牽引力のダイナミクスとメカノトランスデューサーの局在応答 Invited

    木戸秋 悟

    ConBio2017  2017.12 

     More details

    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • Migration model based on persistent fluctuation of cell shape International conference

    Hiroyuki Ebata, Aki Yamamoto, and Satoru Kidoaki

    SFS2017  2017.11 

     More details

    Event date: 2017.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Sendai   Country:Japan  

  • 多糖類ナノファイバー分散培地を用いた間葉系幹細胞の品質保持培養

    乕谷 翠,辻 ゆきえ, @林 寿人, @岩間 武久, @堀川 雅人, 木戸秋 悟

    第39回日本バイオマテリアル学会大会  2017.11 

     More details

    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • ゼラチンゲルの微視的力学場設計による幹細胞操作 Invited

    木戸秋 悟

    ライフサイエンスバイオマテリアル研究会  2017.10 

     More details

    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 後退界面によって形成される金ナノロッドの直線状凝集体

    栗村 朋, 武仲 能子, 木戸秋 悟, 市川 正敏

    日本物理学会2017年秋季大会  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岩手   Country:Japan  

  • 形態の持続的揺らぎに基づく細胞運動モデル

    江端 宏之, 山本 安希, 木戸秋 悟

    日本物理学会2017年秋季大会  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岩手   Country:Japan  

  • 力学的強度の空間分布制御を可能とする光架橋性コラーゲンゲルの開発

    藤澤 貴宏, 木戸秋 悟

    第66回高分子討論会  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese  

    Venue:松山   Country:Japan  

  • マルチスケールリンクルハイドロゲルの開発

    佐々木 沙織, 江端 宏之, 木戸秋 悟

    第66回高分子討論会  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:松山   Country:Japan  

  • Mechanobio-Materials Manipulating Motility and Functions of Stem Cells Invited

    Satoru Kidoaki

    第55回日本生物物理学会年会  2017.9 

     More details

    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • 金ナノロッドがつくる脱濡れパターンと配線への応用可能性

    栗村 朋, 武仲 能子, 木戸秋 悟, 市川 正敏

    第68回コロイドおよび界面化学討論会  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • 微視的培養力学場設計による細胞行動・機能操作 Invited

    木戸秋 悟

    第78回応用物理学会秋季学術講演会  2017.9 

     More details

    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Surface Structural Control of Wrinkled gel for Cell Culture International conference

    S. Sasaki, H. Ebata, and S. Kidoaki

    IUMRS2017  2017.8 

     More details

    Event date: 2017.8 - 2017.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Kyoto   Country:Japan  

  • Mechanobio-materials manipulating motility and functions of stem cells Invited International conference

    Satoru Kidoaki

    ISOMRM2017  2017.8 

     More details

    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taoyuan   Country:Taiwan, Province of China  

  • Mechanotransduction and redox balance of stem cells

    T. Kuboki, @F. Kantawong, and S. Kidoaki1

    BMI2017  2017.8 

     More details

    Event date: 2017.8

    Language:English  

    Venue:Fukuoka   Country:Japan  

  • 幹細胞を休眠させる分散固相足場材料 Invited

    木戸秋 悟

    第54回化学関連支部合同九州大会  2017.7 

     More details

    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州市   Country:Japan  

  • Mechanotrasduction and redox balance of stem cells International conference

    Thasaneeya Kuboki, @Fahsai Kantawong ,and Satoru Kidoaki

    ISB2017  2017.6 

     More details

    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Brisbane   Country:Australia  

  • Characterization of the frustrated differentiation of mesenchymal stem cells induced by nomadic migration between stiff and soft region of gel matrix International conference

    Satoru Kidoaki, Hiroyuki Ebata, @Rumi Sawada, Kouske Moriyama, Thasaneeya Kuboki, @Ken Kono, @Kazusa Tanaka, Saori Sasaki

    ISB2017  2017.6 

     More details

    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Brisbane   Country:Australia  

  • Negative mechanotaxis of iPS cells observed on microelastically-patterned hydrogels International conference

    Satoru Kidoaki, #Kenta Mizumoto

    Single-Cell Biophysics: Measurement, Modulation, and Modeling  2017.6 

     More details

    Event date: 2017.6

    Language:English  

    Venue:Taipei   Country:Taiwan, Province of China  

  • Comprehensive gene expression analysis of human mesenchymal stem cells cultured on the micro elastically-striped pattern gel matrix International conference

    @Rumi Sawada, @Ken Kono, @Kazusa Tanaka, @Yoji Sato, Kousuke Moriyama,  Hiroyuki Ebata, Saori Sasaki, Thasaneeya Kuboki, Satoru Kidoaki

    ISSCR2017  2017.6 

     More details

    Event date: 2017.6

    Language:English  

    Venue:Boston   Country:Armenia  

  • 幹細胞の品質保持のための培養力学場設計 Invited

    木戸秋 悟

    第56回日本生体医工学会  2017.5 

     More details

    Event date: 2017.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東北大学医学部星稜キャンパス   Country:Japan  

  • 幹細胞分化フラストレーションの検証経過について

    木戸秋 悟

    第2回メカノバイオロジー学会  2017.3 

     More details

    Event date: 2017.3

    Language:Japanese  

    Venue:京都大学   Country:Japan  

  • ヒト間葉系幹細胞の分化フラストレート培養における網羅的遺伝子発現解析

    澤田 留美, 森山 幸祐, 河野 健, 田中和沙, 佐藤陽治, 江端 宏之, 佐々木 沙織, Thasaneeya Kuboki, 木戸秋 悟

    第16回日本再生医療学会総会  2017.3 

     More details

    Event date: 2017.3

    Language:Japanese  

    Venue:仙台国際センター   Country:Japan  

  • 多糖類ナノファイバー分散培地を用いた間葉系幹細胞の品質保持休眠培養

    木戸秋 悟, 乕谷 翠, 辻 ゆきえ, 林寿人, 岩間武久, 堀川雅人

    第16回日本再生医療学会総会  2017.3 

     More details

    Event date: 2017.3

    Language:Japanese  

    Venue:仙台国際センター   Country:Japan  

  • ラミニン固定化弾性率可変ハイドロゲル基材を用いたiPS細胞のフィーダーフリー分散培養

    水本 健太, 木戸秋 悟

    第16回日本再生医療学会総会  2017.3 

     More details

    Event date: 2017.3

    Language:Japanese  

    Venue:仙台国際センター   Country:Japan  

  • Designing Wrinkled Hydrogels for Cell Manipulation International conference

    Saori Sasaki, Hiroyuki Ebata, Takuya Ohzono, Satoru Kidoaki

    Gel Symposium 2017  2017.3 

     More details

    Event date: 2017.3

    Language:English  

    Venue:日本大学 津田沼キャンパス   Country:Japan  

  • 間葉系幹細胞の運動及び分化ベクトルを操作する基材弾性率閾値条件の決定

    森山 幸祐, Thasaneeya Kuboki, 木戸秋 悟

    化学工学会 第82年会  2017.3 

     More details

    Event date: 2017.3

    Language:Japanese  

    Venue:芝浦工業大学   Country:Japan  

  • 細胞を操るナノ・マイクロファイバーシステム Invited

    木戸秋 悟

    第67回医用高分子研究会  2017.3 

     More details

    Event date: 2017.3

    Language:Japanese  

    Venue:東京理科大学   Country:Japan  

  • Characterization of the frustrated differentiation of mesenchymal stem cells induced by normadic migration between stiff and soft region of gel matrix International conference

    Satoru Kidoaki, Hiroyuki Ebata, Rumi Sawada, Kousuke Moriyama, Thasaneeya Kuboki, Ken Kono, Kazusa Tanaka, Satori Sasaki

    Biophysical Society 61th Annual Meeting  2017.2 

     More details

    Event date: 2017.2

    Language:English  

    Venue:New Orleans   Country:United States  

  • ゲル表面を這う細胞の変形と運動のダイナミクス

    江端 宏之, 山本 安希, 木戸秋 悟

    アクティブマター研究会2017  2017.1 

     More details

    Event date: 2017.1

    Language:Japanese  

    Venue:九州大学 西新プラザ   Country:Japan  

  • 細胞行動を操作するハイドロゲル微視的力学場設計 Invited

    木戸秋 悟

    アクティブマター研究会2017  2017.1 

     More details

    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学 西新プラザ   Country:Japan  

  • Analysis of dynamics of mechano-signal input for stem cells cultured on the micro-elastically patterned hydrogels International conference

    Hiroyuki Ebata, Kouske Hamano, Satoru Kidoaki

    International polymer conference 2016  2016.12 

     More details

    Event date: 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Fukuoka International Congress Center   Country:Japan  

  • 力学的強度の制御を可能とする光架橋性コラーゲンゲルの開発

    藤澤 貴宏, 木戸秋 悟

    第54回日本生物物理学会年会  2016.11 

     More details

    Event date: 2016.11

    Language:Japanese  

    Venue:つくば国際会議場   Country:Japan  

  • 分散培養iPS細胞の増殖応答性に対するハイドロゲル表面へのラミニン修飾状態の本質的効果

    水本 健太, 木戸秋 悟

    第54回日本生物物理学会年会  2016.11 

     More details

    Event date: 2016.11

    Language:Japanese  

    Venue:つくば国際会議場   Country:Japan  

  • ヒト間葉系幹細胞の培養力学場応答性に関する網羅的遺伝子発現解析

    澤田 留美, 河野 健, 田中 和沙, 佐藤 陽治, 森山 幸祐, 江端 宏之, 佐々木 沙織, KUBOKI THASANEEYA, 木戸秋 悟

    日本バイオマテリアル学会シンポジウム2016  2016.11 

     More details

    Event date: 2016.11

    Language:Japanese  

    Venue:福岡国際会議場   Country:Japan  

  • iPS細胞の分散培養最適化のためのラミニン固定化弾性率可変ハイドロゲル基材の設計

    水本 健太, 木戸秋 悟

    日本バイオマテリアル学会シンポジウム2016  2016.11 

     More details

    Event date: 2016.11

    Language:Japanese  

    Venue:福岡国際会議場   Country:Japan  

  • がん細胞の浸潤能診断のための弾性率可変マイクロファイバーゲルマトリックスの設計

    仲村 悠, 木戸秋 悟

    日本バイオマテリアル学会シンポジウム2016  2016.11 

     More details

    Event date: 2016.11

    Language:Japanese  

    Venue:福岡国際会議場   Country:Japan  

  • 多糖類ナノファイバー分散培地を用いた間葉系幹細胞の品質保持休眠培養

    乕谷 翠, 辻 ゆきえ, 林寿人, 岩間武久, 堀川雅人, 木戸秋 悟

    日本バイオマテリアル学会シンポジウム2016  2016.11 

     More details

    Event date: 2016.11

    Language:Japanese  

    Venue:福岡国際会議場   Country:Japan  

  • Mechanotransduction and redox signaling in stem cells International conference

    Thasaneeya Kuboki, Satoru Kidoaki, Fahsai Kantawong

    Mechanobiology of Disease  2016.9 

     More details

    Event date: 2016.9

    Language:English  

    Venue:National University of Singapore   Country:Singapore  

  • 力学的強度の制御を可能とする光架橋性コラーゲンゲルの開発

    藤澤 貴宏, 木戸秋 悟

    第65回高分子討論会  2016.9 

     More details

    Event date: 2016.9

    Language:Japanese  

    Venue:神奈川大学   Country:Japan  

  • 細胞培養リンクルハイドロゲルの開発と設計

    佐々木 沙織, 江端 宏之, 大園 拓哉, 木戸秋 悟

    第65回高分子討論会  2016.9 

     More details

    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川大学   Country:Japan  

  • 非一様弾性基材上で培養された幹細胞におけるメカノシグナル動的入力特性の解析

    江端 宏之, 濱野 浩佑, 木戸秋 悟

    第65回高分子討論会  2016.9 

     More details

    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川大学   Country:Japan  

  • Live imaging of paxillin in durotactic migrating cells on the microelastically patterned hydrogels International conference

    THASANEEYA KUBOKI, Tomoki Matsuda, Takeharu Nagai, Hiroyuki Ebata, Satoru Kidoaki

    KJF-ICOMEP 2016  2016.9 

     More details

    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Fukuoka   Country:Japan  

  • Surface elasticity tunable gelatinous gel for manipulation of stem cell fate determination and directional cell migration International conference

    THASANEEYA KUBOKI, Satoru Kidoaki

    6th International Polymer Conference of Thailand  2016.6 

     More details

    Event date: 2016.6 - 2016.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Bangkok   Country:Thailand  

  • Traction force microscopy of mesenchymal stem cells in mode of frustrated differentiation International conference

    Satoru Kidoaki, Kouske Hamano, THASANEEYA KUBOKI

    10th World Biomaterials Congress  2016.5 

     More details

    Event date: 2016.5

    Language:English  

    Venue:Montreal   Country:Canada  

  • 分化フラストレート幹細胞の牽引力顕微解析

    木戸秋 悟

    第一回日本メカノバイオロジー学会学術大会  2016.3 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学 理学部   Country:Japan  

  • Live imaging of paxillin in durotactic migrating cells on the micro-elastically patterned hydrogels Invited

    Thasaneeya Kuboki, Takeharu Nagai, Yoshiyuki Arai, Tomoki Matsuda, Satoru Kidoaki

    日本機械学会第28回バイオエンジアリング講演会  2016.1 

     More details

    Event date: 2016.1

    Language:English   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 幹細胞を操作するメカノバイオマテリアルの設計 Invited

    木戸秋 悟

    日本化学会 平成27年度先端技術講演会  2015.12 

     More details

    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  • 細胞を操作するマイクロ・ナノメカニクスシステム Invited

    木戸秋 悟

    化学とマイクロ・ナノシステム学会 第32回研究会  2015.11 

     More details

    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • Mechanobio-materials manipulating motility and functions of stem cells Invited International conference

    Satoru Kidoaki

    26th 2015 International Symposium on Micro-NanoMechatronics and Human Science  2015.11 

     More details

    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • ラミニン固定化弾性率可変ゼラチンゲルを用いた分散培養iPS細胞の増殖挙動解析

    水本 健太, 木戸秋 悟

    第37回バイオマテリアル学会  2015.11 

     More details

    Event date: 2015.11

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 幹細胞操作メカノバイオマテリアル

    木戸秋 悟

    科学技術振興機構 CRESTさきがけ 3領域合同第3回シンポジウム  2015.9 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:品川   Country:Japan  

  • Traction force microscopy of mesenchymal stem cells in mode of frustrated differentiation Invited International conference

    Satoru Kidoaki

    iCeMS International Symposium, Hierarchical Dynamics in Soft Materials and Biological Matter  2015.9 

     More details

    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Kyoto   Country:Japan  

  • Redox gene expression of adipose-derived stem cells in response to soft hydrogel International conference

    Fahasai Kantawong, Thasaneeya Kuboki, Satoru Kidoaki

    The 8th Asian-Pacific Conference on Biomechanics 2015  2015.9 

     More details

    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Sapporo   Country:Japan  

  • Traction force microscopy of mesenchymal stem cells in mode of frustrated differentiation International conference

    Satoru Kidoaki

    The 8th Asian-Pacific Conference on Biomechanics 2015  2015.9 

     More details

    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Sapporo   Country:Japan  

  • 多糖類ナノファイバー分散培地を用いた間葉系幹細胞の品質保持休眠培養

    木戸秋 悟, 辻 ゆきえ, 林 寿人, 岩間 武久, 堀川 雅人

    第64回高分子討論会  2015.9 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • 弾性率可変マイクロファイバーゲルマトリックスにおけるがん細胞の三次元運動表現型評価

    仲村 悠, 木戸秋 悟

    第53回日本生物物理学会  2015.9 

     More details

    Event date: 2015.9

    Language:Japanese  

    Venue:金沢   Country:Japan  

  • ハイドロゲルの表面力学場及び表面生化学の両条件に対する分散培養iPS細胞の増殖応答性

    水本 健太, 木戸秋 悟

    第53回日本生物物理学会  2015.9 

     More details

    Event date: 2015.9

    Language:Japanese  

    Venue:金沢   Country:Japan  

  • Manipulation of cell mechanotaxis by designing curvature of the elasticity boundary on hydrogel matrix Invited International conference

    Satoru Kidoaki, Ayaka Ueki

    27th European Conference on Biomaterials ESB2015  2015.8 

     More details

    Event date: 2015.8 - 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Krakow   Country:Poland  

  • Traction force microscopy of mesenchymal stem cells in mode of frustrated differentiation Invited

    Satoru Kidoaki

    International Symposuim on Nanoarchitectonics for Mechanobiology (ISNM)  2015.7 

     More details

    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Tsukuba   Country:Japan  

  • Mechanobio-Materials Manipulating Cell Motility and Functions Invited International conference

    Satoru Kidoaki

    NIMS Conference 2014  2014.7 

     More details

    Event date: 2015.7 - 2014.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:エポカルつくば   Country:Japan  

  • 間葉系幹細胞における基材牽引力と分化マーカー発現の定量的相関解析

    濱野 浩佑, 木戸秋 悟

    第36回日本バイオマテリアル学会大会  2014.11 

     More details

    Event date: 2014.11

    Language:Japanese  

    Venue:タワーホール船堀   Country:Japan  

  • 運動表現型診断のための流れー弾性場共役細胞クロマトグラフィー

    久保田 有貴, 木戸秋 悟

    第36回バイオマテリアル学会  2014.11 

     More details

    Event date: 2014.11

    Language:Japanese  

    Venue:タワーホール船堀   Country:Japan  

  • 細胞運動表現型診断のための微視的培養力学場設計

    木戸秋 悟, 上村 洋介, 坂下 寛幸

    第63回高分子討論会  2014.9 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎大学   Country:Japan  

  • 幹細胞操作メカノバイオマテリアル

    木戸秋 悟, 陣内 秀平, 内海 彩香

    第63回高分子討論会  2014.9 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎大学   Country:Japan  

  • 幹細胞の品質保持・高速増殖培養のためのメカノバイオロジー最適化材料の設計

    木戸秋 悟

    バイオマテリアル学会九州ブロック講演会  2014.9 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学椎木講堂   Country:Japan  

  • 幹細胞分化フラストレーション培養技術の開発

    木戸秋 悟

    九州大学生体材料・力学研究会  2014.8 

     More details

    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学医学部百年記念講堂   Country:Japan  

  • Time-dependent migratory behaviors in the long-term studies of fibroblast durotaxis on a hydrogel substrate fabricated with a soft band International conference

    Wei Chen, Thasaneeya Kuboki, Satoru Kidoaki

    248th ACS National Meeting  2014.8 

     More details

    Event date: 2014.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:San Francisco Hall   Country:United States  

  • 培養力学場最適化によるiPS細胞の高速増殖技術 Invited

    木戸秋 悟

    機会学会分科会  2014.7 

     More details

    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学工学部   Country:Japan  

  • Time-dependent migratory behaviors in the long-term studies of fibroblast durotaxis on a hydrogel substrate fabricated with a soft band International conference

    Thasaneeya Kuboki, Satoru Kidoaki

    International Society for Mechanobiology 2014  2014.5 

     More details

    Event date: 2014.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岡山大学   Country:Japan  

  • Mechaobio-materials manipulating cell motility and functions International conference

    Satoru Kidoaki

    International Society for Mechanobiology 2014  2014.5 

     More details

    Event date: 2014.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岡山大学   Country:Japan  

  • Mechanobio-Materials Manipulating Cell Motility and Functions Invited International conference

    Satoru Kidoaki*

    Joint international symposium on "Nature-inspired Technology(ISNIT) 2014" and "Engineering Neo-biomimetics V"  2014.2 

     More details

    Event date: 2014.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:北海道大学学術交流会館   Country:Japan  

  • Mechanobio-materials manipulating cell motility and functions Invited International conference

    Satoru Kidoaki*

    The 17th SANKEN International Symposium 2014/ The 2nd International Symposium of Nano-Macro materials Devices and System Research Alliance Project  2014.1 

     More details

    Event date: 2014.1

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Icho Kaikan, Osaka University   Country:Japan  

  • "Mechanobio-Materials": Design of Elastically-Micropatterned Gels To Control Cell Mechanotaxis And Motility-Related Functions Invited International conference

    Satoru Kidoaki*

    The 15th International Conference on Biomedical Engineering  2013.12 

     More details

    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:National University of SIngapore   Country:Singapore  

  • UCST型ウレイド高分子と生体分子の相互作用

    宿利沙郁可, 河野貴国, 木戸秋 悟, 嶋田直彦, 丸山厚

    第35回日本バイオマテリアル学会大会  2013.11 

     More details

    Event date: 2013.11

    Language:Japanese  

    Venue:タワーホール船堀   Country:Japan  

  • ラミニン固定化弾性率可変ゼラチンゲルを用いたiPS 細胞のフィーダーフリー分散培養

    内海彩香, 奥田 竜也, 遠藤大, 小池朋, 江藤浩之, 木戸秋 悟

    第35回日本バイオマテリアル学会大会  2013.11 

     More details

    Event date: 2013.11

    Language:Japanese  

    Venue:タワーホール船堀   Country:Japan  

  • 細胞の三次元運動を制御するナノ・マイクロファイバーゲルマトリックスの力学場設計

    緒方彩, 木戸秋 悟

    第35回日本バイオマテリアル学会大会  2013.11 

     More details

    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:タワーホール船堀   Country:Japan  

  • 大面積弾性マイクロパターニングゲルを用いた間葉系幹細胞の分化フラストレーションの誘導と評価

    浜野浩佑, 木戸秋 悟

    第51回生物物理学会  2013.10 

     More details

    Event date: 2013.10

    Language:Japanese  

    Venue:国立京都国際会議場   Country:Japan  

  • 波型弾性パターニングゲル上での流れ誘導メカノタクシスに見られるがん細胞の接着スイッチング挙動

    久保田有貴, 木戸秋 悟

    第51回生物物理学会  2013.10 

     More details

    Event date: 2013.10

    Language:Japanese  

    Venue:国立京都国際会議場   Country:Japan  

  • ナノ・マイクロファイバーゲルマトリックスの弾性設計による三次元細胞運動制御

    緒方彩, 木戸秋 悟

    第51回生物物理学会  2013.10 

     More details

    Event date: 2013.10

    Language:Japanese  

    Venue:国立京都国際会議場   Country:Japan  

  • ラミニン固定化弾性率可変ゼラチンゲルを用いたiPS 細胞のフィーダーフリー分散培養

    内海彩香, 奥田 竜也, 遠藤大, 小池朋, 江藤浩之, 木戸秋 悟

    第51回生物物理学会  2013.10 

     More details

    Event date: 2013.10

    Language:Japanese  

    Venue:国立京都国際会館   Country:Japan  

  • フローストレッチング法によるポリカチオンくし型共重合体・DNA相互作用の一分子観察

    解妍, 山崎康平, 尊田尚孝, 嶋田直彦, 木戸秋 悟, 真栄城正寿, 宮崎真佐也, 丸山厚

    第62回高分子討論会  2013.9 

     More details

    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢大学 角間キャンパス   Country:Japan  

  • ラミニン固定化弾性率可変ゼラチンゲルを用いたiPS 細胞のフィーダーフリー分散培養

    内海彩香, 奥田 竜也, 遠藤大, 小池朋, 江藤浩之, 木戸秋 悟

    第62回高分子討論会  2013.9 

     More details

    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢大学角間キャンパス   Country:Japan  

  • Frustrated differentiation of mesenchymal stem cell cultured on microelastically-patterned photocurable gelatinous gels Invited International conference

    Satoru Kidoaki*

    The 7th World Congress on Biomimetics, Artificial Muscles and Nano-Bio(BAMN2013)  2013.8 

     More details

    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:韓国済州島グランドホテル   Country:Korea, Republic of  

  • Controlling mechano-repellent cell migration induced by a micro-scale soft band on a hydrogel matrix International conference

    Thasaneeya Kuboki, Wei Chen, Satoru Kidoaki*

    Sydney International Nanomedicine Conference  2013.7 

     More details

    Event date: 2013.7

    Language:English  

    Venue:Sydney InterContinental Hotel   Country:Australia  

  • 細胞操作メカノバイオマテリアル Invited

    木戸秋 悟

    第17回バイオレオロジー・リサーチ・フォーラム  2013.6 

     More details

    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学西新プラザ   Country:Japan  

  • 幹細胞メカノバイオミメティックス:微視的培養力学場設計に基づく幹細胞分化フラストレーションの誘導

    木戸秋 悟、陣内 秀平

    日本化学会第92春季年会  2012.3 

     More details

    Event date: 2012.3

    Presentation type:Oral presentation (general)  

    Venue:慶応大学日吉キャンパス   Country:Japan  

  • Frustrated differentiation of mesenchymal stem cell cultured on microelastically-patterned photocurable gelatinous gels International conference

    Satoru Kidoaki, Shuhei Jinnouchi

    アメリカ生物物理学会  2012.2 

     More details

    Event date: 2012.2

    Venue:サンディエゴコンベンションセンター   Country:United States  

  • 弾性マイクロパターニングゲルを用いた細胞機能操作 Invited

    木戸秋 悟

    プラスチック成形加工学会第127回講演会  2012.2 

     More details

    Event date: 2012.2

    Presentation type:Oral presentation (general)  

    Venue:工学院大学新宿キャンパス   Country:Japan  

  • Embedding Scaffold-Expander Microgels into Electrospun Nanofiber Meshes by Cross-Spraying Electrospinning

    Naomi Kadowaki, Naohiko Shimada, Atsushi Maruyama, Satoru Kidoaki

    第21回日本MRS学術シンポジウム  2011.12 

     More details

    Event date: 2011.12

    Venue:横浜市開港記念会館、横浜情報文化センター   Country:Japan  

  • Cell Thigmotaxis regulation by fiber matrix patterning

    Ryosuke Ando, Satoru Kidoaki

    第21回日本MRS学術シンポジウム  2011.12 

     More details

    Event date: 2011.12

    Venue:横浜市開港記念会館、横浜情報文化センター   Country:Japan  

  • Threshold Conditions to Induce Cellular Mechanotaxis: Microelasticity Gradient and Cell Seeding Density

    Yosuke Uemura, Satoru Kidoaki

    第21回日本MRS学術シンポジウム  2011.12 

     More details

    Event date: 2011.12

    Venue:横浜市開港記念会館、横浜情報文化センター   Country:Japan  

  • Frustrated Differentiation of Mesenchymal Stem Cells Cultured on Microelastically-Patterned Photocurable Gelatinous Gels

    Jinnouchi Shuhei, Satoru Kidoaki

    第21回日本MRS学術シンポジウム  2011.12 

     More details

    Event date: 2011.12

    Venue:横浜市開港記念会館、横浜情報文化センター   Country:Japan  

  • Mechanobio-materials: Development of micropatterned elastic gels to control cell mechanotaxis and motility-related functions International conference

    Satoru Kidoaki

    4th International Conference on Mechanics of Biomaterials & Tissues  2011.12 

     More details

    Event date: 2011.12

    Venue:Marriot Resort, Waikoloa, Hawaii   Country:Japan  

  • メカノバイオマテリアル:細胞運動・機能を操作する微視的培養力学場設計 Invited

    木戸秋 悟

    第34回材料講習会 「バイオマテリアルと再生医工学」  2011.12 

     More details

    Event date: 2011.12

    Presentation type:Oral presentation (general)  

    Venue:京都大学再生医科学研究所   Country:Japan  

  • “Mechanobio-materials”: design of micropatterned elastic gels to control cell mechanotaxis and motility-related functions International conference

    Satoru Kidoaki

    7th International Symposium on Environmentally Conscious Design and Inverse Manufacturing  2011.12 

     More details

    Event date: 2011.11 - 2011.12

    Presentation type:Oral presentation (general)  

    Venue:Kyoto Terusa   Country:Japan  

  • “Mechanobio-materials”: design of micropatterned elastic gels to control cell mechanotaxis and motility-related functions International conference

    Satoru Kidoaki

    International Symposium on Mechanobiology  2011.11 

     More details

    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Venue:Shanghai Huashia Hotel   Country:Japan  

  • メカノバイオマテリアル:細胞運動・機能を操作する微視的培養力学場設計 Invited

    木戸秋 悟

    第60 回高分子討論会  2011.9 

     More details

    Event date: 2011.9

    Presentation type:Oral presentation (general)  

    Venue:岡山大学津島キャンパス   Country:Japan  

  • “Mechanobio-materials”: design of micropatterned elastic gels to control cell mechanotaxis and motility-related functions International conference

    Satoru Kidoaki

    The 3rd Asian Symposium on Advanced Materials – Chemistry & Physics of Func4onal Materials – (ASAM-­‐3)  2011.9 

     More details

    Event date: 2011.9

    Presentation type:Oral presentation (general)  

    Venue:Kyushu University Chikushi Campus, C-Cube   Country:Japan  

  • メカノバイオマテリアル:細胞運動・機能を操作する微視的培養力学場設計

    木戸秋 悟

    日本バイオマテリアル学会九州ブロック キックオフシンポジウム  2011.3 

     More details

    Event date: 2011.3

    Presentation type:Oral presentation (general)  

    Venue:九州大学医学部百年講堂   Country:Japan  

  • Development of micropatterned elastic gels to control cell mechanotaxis and motility-related functions International conference

    S. Kidoaki

    International Symposium on Actin, the Cytoskeleton, and the Nucleus  2010.11 

     More details

    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Venue:National University of Singapore, Mechanobiology Institute   Country:Singapore  

  • 弾性勾配ゲル界面における細胞接着牽引力分布の局所ダイナミクス解析

    鶴崎聡、木戸秋悟

    第48回生物物理学会年会  2010.9 

     More details

    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:東北大学川内キャンパス   Country:Japan  

  • “Mechanobio-materials”: design of micropatterned elastic gels to control cell mechanotaxis and motility-related functions Invited

    S. Kidoaki

    第48回生物物理学会年会  2010.9 

     More details

    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:東北大学川内キャンパス   Country:Japan  

  • 非対称弾性勾配ゲルを用いた細胞運動の長距離整流化

    坂下寛幸、木戸秋悟

    第48回生物物理学会年会  2010.9 

     More details

    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:東北大学川内キャンパス   Country:Japan  

  • 細胞培養力学場設計に基づく遺伝子導入効率のメカニカル制御

    中島啓、奥田竜也、久保木タッサニーヤー、木戸秋悟

    第48回生物物理学会年会  2010.9 

     More details

    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:東北大学川内キャンパス   Country:Japan  

  • 微視的培養力学場設計による細胞運動制御

    坂下寛幸•木戸秋悟

    第59回高分子討論会  2010.9 

     More details

    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:北海道大学高等教育機能開発総合センター   Country:Japan  

  • バイオケミカルモジュレーションを指向した局所多剤時間差投薬システムの開発

    奥田竜也・木戸秋悟

    第59回高分子討論会  2010.9 

     More details

    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:北海道大学高等教育機能開発総合センター   Country:Japan  

  • 微視的材料力学場設計による細胞機能制御: メカノバイオマテリアルの創製 Invited

    木戸秋 悟

    25th Summer University in Hokkaido  2010.8 

     More details

    Event date: 2010.8

    Presentation type:Oral presentation (general)  

    Venue:洞爺湖サンパレス   Country:Japan  

  • Development of micropatterned elastic gels to control cell mechanotaxis Invited International conference

    S. Kidoaki, T. Kawano, and H. Sakashita

    International Symposium on Polymer Chemistry (PC2010)  2010.6 

     More details

    Event date: 2010.6

    Presentation type:Oral presentation (general)  

    Venue:竹輝飯店(蘇州市)   Country:China  

  • Development of Micropatterned Elastic Gels to Control Cell Mechanotaxis and Motility-Related Functions Invited International conference

    S. Kidoaki

    International Symposium of Joint Research Network on Advanced Materials and Devices  2010.3 

     More details

    Event date: 2010.3

    Presentation type:Oral presentation (general)  

    Venue:Hotel Nidom, Hokkaido   Country:Japan  

  • Development of micropatterned elastic gels to control cell mechanotaxis International conference

    S. Kidoaki, T. Kawano, H. Sakashita

    54th Annual Meeting, Biophysical Society  2010.2 

     More details

    Event date: 2010.2

    Presentation type:Oral presentation (general)  

    Venue:San Fransisco   Country:United States  

  • 微視的培養力学場設計による細胞運動・機能の連動操作材料の構築 Invited

    木戸秋 悟

    第12回CREST中山チームミーティング  2012.3 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:休暇村 志賀島   Country:Japan  

  • 微視的培養力学場設計による細胞運動・機能の連動操作材料の構築 Invited

    木戸秋 悟

    平成23 年度GIGNO 研究領域創成支援プロジェクト ワークショップ  2012.3 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京工業大学 キャンパスイノベーションセンター   Country:Japan  

  • 微視的培養力学場設計に基づく幹細胞分化フラストレーションの誘導

    木戸秋 悟

    第51回日本生体医工学会大会  2012.5 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場   Country:Japan  

  • Development of multidrug delivery system for biochemical modulation by nano-/micro-mesh technology Invited International conference

    奥田 竜也, 富永賢吾, 木戸秋 悟

    7th International Symposium on High-tech Polymer Materials (HTPM-VII)  2012.6 

     More details

    Language:English   Presentation type:Oral presentation (general)  

    Venue:西安ガーデンホテル   Country:China  

  • ナノ・マイクロファイバーゲルマトリックスの弾性設計による細胞の三次元メカノタクシスの誘導

    緒方 彩, 木戸秋 悟

    生体機能関連化学若手の会・第24回サマースクール  2012.7 

     More details

    Language:Japanese  

    Venue:志賀島   Country:Japan  

  • 微視的弾性境界の曲率設計による細胞メカノタクシスの高効率誘導

    内海彩香, 木戸秋 悟

    生体機能関連化学若手の会・第24回サマースクール  2012.7 

     More details

    Language:Japanese  

    Venue:志賀島   Country:Japan  

  • Frustrated Differentiation of Mesenchymal Stem Cell Cultured on Microelastically-Patterned Photocurable Gelatinous Gels International conference

    Satoru Kidoaki, Syuhei Jinnouchi

    The 2012 International Conference on Flexible and Printed Electronics  2012.9 

     More details

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Yasuda Auditorium, Hongo Campus The University of Tokyo   Country:Japan  

  • Mechanical control of 3-D cell movement in elastically-micropatterned matrix of micro-fiber gels

    緒方彩, 木戸秋 悟

    第50回生物物理学会年会  2012.9 

     More details

    Language:Japanese  

    Venue:名古屋大学   Country:Japan  

  • Efficient manipulation of cell mechanotaxis: effect of the curvature of micro-elasticity boundary

    内海彩香, 木戸秋 悟

    第50回生物物理学会年会  2012.9 

     More details

    Language:Japanese  

    Venue:名古屋大学   Country:Japan  

  • “Mechanobio-Materials”: Design of Elastically-Micropatterned Gels To Control Cell Mechanotaxis and Motility-Related Functions Invited International conference

    Satoru Kidoaki, Takahito Kawano, Hiroyuki Sakashita

    IEEE-NMDC2012  2012.10 

     More details

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Hyatt Regency Waikiki Beach Resort and Spa   Country:United States  

  • 電界紡糸ナノ・マイクロファイバーメッシュテクノロジー:細胞内殖促進技術の新展開 Invited

    木戸秋 悟, 門脇 直美, 緒方 彩

    第21回ポリマー材料フォーラム  2012.11 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州国際会議場   Country:Japan  

  • 細胞の三次元運動を制御するナノ・マイクロファイバーゲルマトリックスの弾性分布設計

    緒方 彩, 木戸秋 悟

    日本バイオマテリアル学会大会シンポジウム2012  2012.11 

     More details

    Language:Japanese  

    Venue:仙台国際センター   Country:Japan  

  • 電界紡糸ナノファイバーマトリックスへの細胞侵入促進技術の開発

    門脇 直美, 木戸秋 悟

    日本バイオマテリアル学会大会シンポジウム2012  2012.11 

     More details

    Language:Japanese  

    Venue:仙台国際センター   Country:Japan  

  • 細胞運動・機能を操作するナノ・マイクロメカニカルシステムの構築 Invited

    木戸秋 悟

    電子科学研究所学術講演会  2013.3 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北大電子研   Country:Japan  

  • 細胞運動・機能を操作するナノ・マイクロメカニカルシステムの構築 Invited

    木戸秋 悟

    新学術「動く細胞と秩序」 第三回 若手の会  2013.11 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ラフォーレ那須   Country:Japan  

  • 細胞操作メカノバイオマテリアル〜細胞メカノバイオロジーを操作するバイオマテリアル〜 Invited

    木戸秋 悟

    千葉大学・上海交通大学共同研究センター特別セミナー  2013.12 

     More details

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:千葉大学   Country:Japan  

  • 細胞操作メカノバイオマテリアル Invited

    木戸秋 悟

    福岡歯科大学再生医学研究センターシンポジウム  2014.2 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡歯科大学   Country:Japan  

  • 細胞操作メカノバイオマテリアル〜細胞メカノバイオロジーを操作するバイオマテリアル〜 Invited

    木戸秋 悟

    山形大学講演会  2014.3 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山形大学工学研究科   Country:Japan  

  • 細胞操作メカノバイオマテリアル〜細胞メカノバイオロジーを操作するバイオマテリアル〜

    木戸秋 悟

    メカノセンシング研究会  2014.3 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:理化学研究所神戸   Country:Japan  

  • 蛍光色素一分子検出技術を用いたプリオン蛋白重合度評価の試み

    柴野智子、佐々木健介、木戸秋悟、岩城徹

    第51回日本神経病理学会総会学術研究会  2010.4 

     More details

    Event date: 2010.4

    Presentation type:Oral presentation (general)  

    Venue:シェーンバッハ・サボー(東京都千代田区 砂防会館別館)   Country:Japan  

  • バイオケミカルモジュレーションを指向した多剤時間差徐放シートの開発

    冨永 賢吾、奥田 竜也、木戸秋 悟

    第31回日本バイオマテリアル学会年会  2009.11 

     More details

    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Venue:京都テルサ   Country:Japan  

  • 非対称弾性勾配ゲルを用いた細胞運動の長距離整流化

    坂下寛幸、木戸秋悟

    第31回日本バイオマテリアル学会年会  2009.11 

     More details

    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Venue:京都テルサ   Country:Japan  

  • クロススプレー電界紡糸を用いたナノファイバー表面の迅速機能化法の開発

    松尾瞳、上山洋一郎、奥田竜也、木戸秋悟

    第31回日本バイオマテリアル学会年会  2009.11 

     More details

    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Venue:京都テルサ   Country:Japan  

  • Differential Proteomic Expression of Mesenchymal Stem Cell on Elastic Matrix in Correlation with Cellular Tensegrity Behavior

    T. Kuboki, F. Kantawong, Y. Shinohara, R. Burchmore, M. J. Dalby and S. Kidoaki

    INTERNATIONAL SYMPOSIUM ON NANOBIO-INTERFACES RELATED TO MOLECULAR MOBILITY  2009.11 

     More details

    Event date: 2009.11

    Venue:東京大学 武田ホール   Country:Japan  

  • Determination of elasticity gradient condition to induce cell mechanotaxis

    T. Kawano and S. Kidoaki

    INTERNATIONAL SYMPOSIUM ON NANOBIO-INTERFACES RELATED TO MOLECULAR MOBILITY  2009.11 

     More details

    Event date: 2009.11

    Venue:東京大学 武田ホール   Country:Japan  

  • Control of Cell Mechanotaxis by the Photocurable Gelatinous Gels with Micropatterned Surface Elasticity Invited

    S. Kidoaki

    INTERNATIONAL SYMPOSIUM ON NANOBIO-INTERFACES RELATED TO MOLECULAR MOBILITY  2009.11 

     More details

    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Venue:東京大学 武田ホール   Country:Japan  

  • 非対称弾性勾配ゲルを用いた細胞運動の長距離整流化

    坂下 寛幸、木戸秋悟

    第47回日本生物物理学会年会  2009.10 

     More details

    Event date: 2009.10 - 2009.11

    Venue:アスティ徳島   Country:Japan  

  • 細胞のメカノタクシスを誘起する弾性勾配条件の決定とフラストレーション運動誘導への応用

    河野 喬仁、木戸秋悟

    第47回日本生物物理学会年会  2009.10 

     More details

    Event date: 2009.10 - 2009.11

    Venue:アスティ徳島   Country:Japan  

  • Development of Micropatterned Elastic Gels to Control Cell Mechanotaxis and Motility-Related Functions Invited

    S. Kidoaki

    International Symposium on Engineering Neo-Biomimetics  2009.10 

     More details

    Event date: 2009.10

    Presentation type:Oral presentation (general)  

    Venue:産業技術総合研究所 臨海副都心センター   Country:Japan  

  • メカノタクシス挙動を誘導する弾性マイクロパターンの設計 International conference

    河野 喬仁、木戸秋 悟

    第61回細胞生物学会年会  2009.9 

     More details

    Event date: 2009.9

    Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋国際会議場   Country:Japan  

  • 材料力学場設計による細胞機能制御:メカノバイオマテリアルの創製 Invited

    木戸秋 悟

    第22回 九州電子顕微鏡技術研究会  2009.9 

     More details

    Event date: 2009.9

    Presentation type:Oral presentation (invited, special)  

    Venue:九州大学伊都キャンパス   Country:Japan  

  • 細胞のメカノタクシスを誘起する弾性マイクロパターニング表面の設計

    河野 喬仁、木戸秋 悟

    第19回バイオ高分子シンポジウム  2009.7 

     More details

    Event date: 2009.7

    Presentation type:Oral presentation (general)  

    Venue:東京大学駒場キャンパス   Country:Japan  

  • Control of cell migration by the photocurable gelatinous gels with micropatterned surface elasticity Invited International conference

    S. Kidoaki

    Sweden-Japan Joint Colloquium on “Frontiers in Nanobiotechnology from Engineering to Application for Cells”  2009.6 

     More details

    Event date: 2009.6

    Presentation type:Oral presentation (general)  

    Venue:AlbaNova University Centre, Royal Institute of Technology (KTH)   Country:Sweden  

  • Vectorial control of cell movement by the design of microelasticity distribution of biomaterial surface Invited International conference

    S. Kidoaki

    ICRA2009  2009.5 

     More details

    Event date: 2009.5

    Presentation type:Oral presentation (general)  

    Venue:神戸コンベンションセンター   Country:Japan  

  • 材料力学場設計による細胞機能のベクトル制御:メカノバイオマテリアルの創製 Invited

    木戸秋 悟

    北陸科学技術大学院大学 マテリアルサイエンス研究科セミナー  2009.1 

     More details

    Event date: 2009.1

    Presentation type:Oral presentation (general)  

    Venue:北陸科学技術大学院大学   Country:Japan  

  • 細胞のフラストレーション運動を誘導する弾性率マイクロパターン表面の設計

    河野 喬仁、木戸秋 悟

    第46回日本生物物理学会年会  2008.12 

     More details

    Event date: 2008.12

    Venue:福岡サンパレス   Country:Japan  

  • Development of Mechanobio-Materials To Manipulate The Cellular Biomechanical Behaviors Invited International conference

    S. Kidoaki

    The 6th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Symposium on Biomaterials  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Country:China  

  • 生体材料表面の弾性分布設計による細胞運動のベクトル制御 Invited

    木戸秋 悟

    産総研講演会  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Venue:産総研四国センター   Country:Japan  

  • Vectorial control of cell movement by the design of microelasticity distribution of biomaterial surface International conference

    S. Kidoaki, T. Matsuda

    International Symposium on Micro-NanoMechatronics and Human Science  2008.11 

     More details

    Event date: 2008.11

    Presentation type:Oral presentation (general)  

    Venue:名古屋大学   Country:Japan  

  • Development of multi-drug delivery system based on the electrospun nano/microfiber mesh technology Invited International conference

    S. Kidoaki

    5th International Symposium on High-tech Polymer Materials (HTPM-V)  2008.10 

     More details

    Event date: 2008.10

    Presentation type:Oral presentation (general)  

    Venue:北京香山飯店   Country:China  

  • 細胞操作ベクトルマトリックス Invited

    木戸秋 悟

    第19回繊維学会西部支部セミナー  2008.10 

     More details

    Event date: 2008.10

    Presentation type:Oral presentation (general)  

    Venue:九州大学   Country:Japan  

  • 材料力学場設計による細胞機能のベクトル制御 Invited

    木戸秋 悟

    高分子夏期大学  2008.7 

     More details

    Event date: 2008.7

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:鹿児島東急ホテル   Country:Japan  

  • マルチドラッグデリバリーシステムのための ナノ・マイクロファイバーメッシュシートの創製

    冨永 賢吾, 奥田 竜也, 木戸秋 悟

    ナノ学会第6回大会  2008.5 

     More details

    Event date: 2008.5

    Venue:九州大学   Country:Japan  

  • 細胞操作材料の高機能化戦略〜メカノバイオロジーの基礎・応用・展望〜 Invited

    木戸秋 悟

    東北大学多元物質科学研究所特別講演会  2008.2 

     More details

    Event date: 2008.2

    Presentation type:Oral presentation (general)  

    Venue:東北大学   Country:Japan  

  • 分子間力プローブ顕微鏡による蛋白質間相互作用の精密解析 Invited

    木戸秋 悟

    高分子学会九州支部 支部フォーラム  2008.1 

     More details

    Event date: 2008.1

    Presentation type:Oral presentation (general)  

    Venue:九州大学   Country:Japan  

  • 生体材料表面の弾性分布設計による細胞行動制御

    木戸秋悟、松田武久

    第45回日本生物物理学会年会  2007.12 

     More details

    Event date: 2007.12

    Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜   Country:Japan  

  • バイオケミカルモジュレーションを指向した複数薬剤時間差徐放シートの創製

    奥田 竜也、冨永 賢吾、木戸秋 悟

    第29回日本バイオマテリアル学会大会  2007.11 

     More details

    Event date: 2007.11

    Presentation type:Oral presentation (general)  

    Venue:吹田市大阪ライフサイエンスセンター   Country:Japan  

  • 電界紡糸ナノ・マイクロファイバーメッシュテクノロジー:医用工学骨格基材の機能的設計 Invited

    木戸秋悟、奥田竜也、松田武久

    プラスチック成形加工学会第15回秋季大会  2007.11 

     More details

    Event date: 2007.11

    Presentation type:Oral presentation (general)  

    Venue:山口県教育会館   Country:Japan  

  • 生体材料表面の弾性分布設計による細胞運動のベクトル制御 Invited

    木戸秋悟

    第38回中部化学関係学協会支部連合秋季大会  2007.11 

     More details

    Event date: 2007.11

    Presentation type:Oral presentation (general)  

    Venue:三重大学   Country:Japan  

  • 生体材料表面の弾性分布設計による細胞運動のベクトル制御

    木戸秋悟、松田武久

    第56回高分子討論会  2007.9 

     More details

    Event date: 2007.9

    Presentation type:Oral presentation (general)  

    Venue:名古屋工業大学   Country:Japan  

  • Control of cell shape, motility and functions by the design of microelasticity distribution of biomaterial surface Invited

    S. Kidoaki

    Japan-Taiwan Bilateral Science & Technology Interchange Project  2007.7 

     More details

    Event date: 2007.7

    Presentation type:Oral presentation (general)  

    Venue:Odawara   Country:Japan  

  • フローストレッチング法によるポリカチオン/DNA複合体の一分子解析

    尊田尚孝, 山崎康平, 嶋田直彦, 狩野 有宏, 木戸秋 悟, 真栄城正寿, 宮崎 真佐也, 丸山 厚

    第22回バイオ高分子シンポジウム  2012.6 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学先端科学技術研究センター   Country:Japan  

  • 生体材料表面の弾性分布設計による細胞行動制御 Invited

    木戸秋 悟、松田 武久

    第28回バイオマテリアル学会大会  2006.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京アルカディア市ヶ谷   Country:Japan  

  • 中性、酸性、塩基性ポリマー混合媒質中での巨大DNAの単分子凝縮転移の特性制御

    木戸秋悟、吉川研一

    日本化学会第72春季年会  1997.3 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 中性ポリマーと塩基性ポリペプチドの共同効果を利用した、巨大DNAの単分子凝縮転移の特性制御

    木戸秋悟、吉川研一

    第23回核酸化学シンポジウム  1996.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:岐阜  

  • 中性ポリマーと、塩基性および酸性ポリペプチド混合系における巨大DNAの単分子凝縮転移

    木戸秋悟、吉川研一

    第45回高分子討論会  1996.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:広島  

  • 巨大DNAの単分子凝縮体の高次構造制御

    木戸秋悟、吉川研一

    第44回高分子討論会  1995.9 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪  

  • 塩基性ポリペプチドによる単分子巨大DNAの凝縮特性制御

    木戸秋悟、吉川研一

    日本化学会第69回春季年会  1995.3 

     More details

    Presentation type:Oral presentation (general)  

    Venue:京都  

  • Complex Formation of DNA with Polycation International conference

    S. Kidoaki and K. Yoshikawa

    International Workshop on Formation and Dynamics of Self-Organized Structures in Surfactant and Polymer Solutions  1994.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:名古屋  

  • DNA/塩基性ポリペプチド複合体の凝縮構造に見られる履歴現象

    木戸秋悟、吉川研一

    日本化学会第67春季年会  1994.3 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 原子間力顕微鏡を用いた蛋白質/材料間の付着力測定:アルカンチオール自己組織化単分子膜表面および光イニファタグラフト重合表面

    木戸秋悟、中山泰秀、松田武久

    第9回バイオ高分子シンポジウム  1999.7 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 光カチオン誘起型高分子フィルム表面での細胞接着性の光制御

    古本昭子、木戸秋悟、中山泰秀、松田武久

    第9回バイオ高分子シンポジウム  1999.7 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 感熱性高分子をグラフトさせたDNAの高次構造転移

    岩瀧敏男、木戸秋悟、木地正美、梅野太輔、吉川研一、前田瑞夫

    第9回バイオ高分子シンポジウム  1999.7 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 原子間力顕微鏡による蛋白質/材料間の相互作用力測定ーアルカンチオール自己組織化単分子膜表面およびイニファタグラフト重合表面

    木戸秋悟、中山泰秀、松田武久

    第48回高分子討論会  1999.10 

     More details

    Presentation type:Oral presentation (general)  

    Venue:新潟  

  • 原子間力顕微鏡によるNIPAMグラフト重合膜の表面力の解析:温度・荷重依存膜厚変化および蛋白質との相互作用

    木戸秋悟、大屋章二、中山泰秀、松田武久

    第10回バイオ高分子シンポジウム  2000.7 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 巨大二重鎖DNA水溶液系の分散安定性:単鎖凝縮体間会合および脱会合の特性解析

    木戸秋悟、吉川研一

    第23回溶液化学シンポジウム  2000.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:岡崎  

  • 巨大二重鎖DNAの単分子脱凝縮転移

    木戸秋悟、吉川研一

    日本化学会第79春季年会  2001.3 

     More details

    Presentation type:Oral presentation (general)  

    Venue:神戸  

  • インターカレーターは巨大二重鎖DNAの折り畳み転移を阻害する

    秋田谷龍男、義永那津人、小穴英廣、木戸秋悟、吉川研一

    日本化学会第79春季年会  2001.3 

     More details

    Presentation type:Oral presentation (general)  

    Venue:神戸  

  • 蛍光標識色素によるDNA折り畳み相転移のシフト

    義永那津人、 秋田谷龍男、 小穴英廣、 木戸秋悟

    日本物理学会第56春季年会  2001.3 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 蛍光・原子間力顕微鏡による巨大二重鎖DNAの階層的コンフォメーション解析

    木戸秋悟、吉川研一

    第50回高分子学会年次大会  2001.5 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪  

  • 人工細胞外マトリックス材料の表面ナノ構造・物性解析:PNIPAM化ゼラチンのマトリックス機能発現性

    大屋章二、木戸秋悟、松田武久、中山泰秀

    第52回高分子学会年次大会  2003.5 

     More details

    Presentation type:Oral presentation (general)  

    Venue:名古屋  

  • 培養細胞における形態ー膜弾性ー細胞骨格間の力学相関:蛍光・原子間力顕微鏡法による解析

    木戸秋悟、松田武久

    第15回バイオエンジニアリング講演会  2003.1 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪  

  • Electrospinningによる機能性ナノファイバーと組織工学

    木戸秋悟、松田武久

    第24回バイオマテリアル学会  2002.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • AFMによるポリ(N-イソプロピルアクリルアミド)化ゼラチンゲルの超微細構造・物性測定とマトリックス機能との相関

    大屋章二、中山泰秀、木戸秋悟、松田武久

    第24回バイオマテリアル学会  2002.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 細胞のナノ・バイオメカニクス:蛍光原子間力顕微鏡法による細胞骨格分布と膜弾性分布の相関解析

    木戸秋悟、松田武久、吉川研一

    第12回バイオ・高分子シンポジウム  2002.8 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • Photocurable liquid biodegradable copolymers: Synthesis of acrylate-endcapped trimethylene carbonate-based copolymers and photocuring

    I. K. Kwon、木戸秋悟、松田武久、Y.H. Kim

    第31回医用高分子シンポジウム  2002.8 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • 細胞の接着・伸展におけるRho familiyの活性化と細胞の形態・運動性:人工基材依存性

    加藤真哉、木戸秋悟、松田武久

    第12回バイオ・高分子シンポジウム  2002.8 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • デンドリティックポリリジン/DNA複合体の時間依存的成長および複合体サイズー遺伝子導入効率の相関

    奥田竜也、新留琢郎、木戸秋悟、大崎美緒、小山義之、吉川研一、青柳東彦

    遺伝子・デリバリー研究会 第3回シンポジウム  2003.5 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京  

  • Electrospinning of Functional Multilayered Nano-Fibers As a Potential Use for Tissue Engineered Matrix International conference

    S. Kidoaki, I.K. Kwon, T. Matsuda

    The 29th Annual Meeting of the Society For Biomaterials  2003.5 

     More details

    Presentation type:Oral presentation (general)  

    Venue:Reno   Country:United States  

  • Electrospinningによる組織工学骨格基材の機能的設計とデバイス化:ナノ・ミクロンファイバーメッシュの積層・混合・チューブ化

    木戸秋悟、I. K. Kwon、井原真紀、松田武久

    第6回日本組織工学会  2003.6 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 蛋白質分子挙動の直接観察とソフトハンドリング:全反射蛍光およびプローブ顕微鏡による蛋白質分子間・蛋白/材料間相互作用のナノメカニクス解析 Invited

    木戸秋悟、A. Idiris、井原 真紀、松田 武久、林崎 良英

    日本顕微鏡学会第48回シンポジウム  2003.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • パターニング培養した血管内皮細胞の形態・膜弾性・骨格構造とNO産生能相関:蛍光・原子間力顕微鏡法による解析

    木戸秋悟、松田武久

    第25回バイオマテリアル学会  2003.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪  

  • 高感度AFMによるタンパク質のソフトハンドリング:高分子プローブの設計と微弱相互作用力の測定

    A. Idiris、木戸秋悟、松田武久、林崎良英

    第25回バイオマテリアル学会  2003.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • Electrospinningによる構造化筒状メッシュの成型加工技術と小口径人工血管のコンプライアンス設計

    井原真紀、木戸秋悟、高見沢計一、松田武久

    第25回バイオマテリアル学会  2003.12 

     More details

    Presentation type:Oral presentation (general)  

    Venue:大阪  

  • Dynamic force spectroscopyによるPDZドメインー認識ペプチド間相互作用の特性解析

    牧禎、木戸秋悟、臼井健悟、鈴木治和、伊藤昌可、林崎良英、松田武久

    第54回高分子討論会  2005.9 

     More details

    Presentation type:Oral presentation (general)  

    Venue:山形大学  

  • マイクロ弾性勾配ゲルを用いた細胞のメカノタクシス制御

    木戸秋悟、松田武久

    第27回バイオマテリアル学会  2005.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:京都テルサ  

  • Dynamic force spectroscopy of specific interaction between PDZ-domain and its recognition peptide International conference

    T. Maki, S. Kidoaki, K. Usui, M. Ito, H. Suzuki,Y. Hayashizaki, T. Matsuda

    20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress  2006.6 

     More details

    Venue:京都国際会議場   Country:Japan  

  • リガンドーレセプタ相互作用力を利用したタンパク質の自発的秩序集合体形成:ナノレゴタンパク質間の相互作用力・集合特性の解析

    牧禎、臼井健吾、木戸秋悟、鈴木治和、伊藤昌可、伊藤吹夕、松田武久、林崎良英

    第55回高分子討論会  2006.9 

     More details

    Presentation type:Oral presentation (general)  

    Venue:富山大学   Country:Japan  

  • Characterization of the cellular biomechanical responses caused on microprocessed substrates: effect of micropatterned cell adhesiveness and microelasticity gradient", International Symposium on Micro-NanoMechantronics and Human Scienecs International conference

    S. Kidoaki, T. Matsuda

    International Symposium on Micro-NanoMechantronics and Human Scienecs, Symposium on "System Cell Engineering by Multi-scale Manipulation"  2006.11 

     More details

    Presentation type:Oral presentation (general)  

    Venue:名古屋大学   Country:Japan  

  • 細胞ホメオスタシスの制御による老化した幹細胞の若返りメカニズムの解明(Elucidation of substrate stiffness mediated rejuvenation mechanism of aging stem cells through the regulation of cellular homeostasis)

    Kuboki Thasaneeya, Kidoaki Satoru

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

     More details

    Language:English  

  • 細胞のかたちづくりの原理に数理と実験で迫る 細胞が細胞を包むしくみ 血管内皮細胞と周皮細胞の場合

    杉原 圭, 佐々木 沙織, 木戸秋 悟, 植村 明嘉, 三浦 岳

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

     More details

    Language:Japanese  

  • 「イメージング技術が解き明かす生体の自律的秩序化」 微小管によるアクチン骨格再編成の時空間的制御メカニズム

    西村 有香子, 久保木 タッサニーニャ, 木戸 秋悟, 茂木 文夫

    バイオイメージング  2023.10  日本バイオイメージング学会

     More details

    Language:Japanese  

  • Stress fiberは細胞周囲の力学的環境の感知にどう影響しているか(How does stress fibers contribute to the sensing of mechanical cues of extracellular environment?)

    勝田 紘基, 奥田 覚, 長山 和亮, 町山 裕亮, 木戸秋 悟, 加藤 昌志, 曽我部 正博, 宮田 卓樹, 平田 宏聡

    日本衛生学雑誌  2023.3  (一社)日本衛生学会

     More details

    Language:English  

▼display all

MISC

  • Musings on ‘Mu’ Invited

    KIDOAKI Satoru

    Seibutsu Butsuri   64 ( 4 )   177 - 177   2024   ISSN:05824052 eISSN:13474219

     More details

    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publisher:The Biophysical Society of Japan General Incorporated Association  

    DOI: 10.2142/biophys.64.177

    CiNii Research

  • 細胞操作変数としての高分子基材の変形特性 Reviewed

    政池 彩雅、木戸秋 悟

    高分子   2022.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 微視的ヘテロ力学場を用いた治療効果増強幹細胞の培養技術

    木戸秋 悟

    医学のあゆみ, 医歯薬出版   2021.2

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 間葉系幹細胞の分化偏向抑制培養ー培養力学場記憶の蓄積回避技術ー

    木戸秋 悟

    生体の科学   2019.8

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • メカノバイオミメティックスによる細胞操作工学

    木戸秋 悟

    CSJ Current Review 28:持続可能性社会を拓くバイオミメティックス』(第13章)   2018.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 微視的弾性勾配場設計による細胞運動操作

    木戸秋 悟

    生物物理   2017.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 細胞接着界面のソフトメカニクス設計による細胞メカノバイオロジーの操作

    木戸秋 悟

    膜 (MEMBRANE)   2017.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 細胞操作メカノバイオマテリアルの設計と幹細胞操作材料への応用

    木戸秋 悟

    Clinical Calcium, 医薬ジャーナル社   2016.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • メカノバイオマテリアル

    木戸秋 悟

    医学のあゆみ, 医歯薬出版   2016.6

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 細胞操作メカノバイオマテリアル

    木戸秋 悟

    バイオマテリアル -生体材料-   2016.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • メカノバイオマテリアル:細胞のメカノバイオロジーを操作する材料

    木戸秋 悟

    日本機械学会誌   2014.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • メカノバイオマテリアル:細胞のメカノバイオロジーを操作する材料力学場設計

    木戸秋 悟

    高分子   2011.5

     More details

    Language:Japanese  

  • 細胞運動・機能を操作する微視的培養力学場設計

    木戸秋 悟

    表面科学   2010.5

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Mechanics in cell adhesion and motility on the elastic substrates

    S. Kidoaki

    Journal of Biomechanical Science and Engineering   2010.4

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 細胞操作弾性界面:微視的材料力学場設計による細胞機能制御

    木戸秋 悟

    バイオマテルアル   2009.7

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 幹細胞の新しい操作技術”-液性因子vs.固相因子

    木戸秋 悟

    化学(化学同人)   2008.9

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 生体材料力学場設計による細胞機能のベクトル制御

    木戸秋悟

    日本化学会生体関連化学部会NewsLetter   2008.2

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ナノ・マイクロファイバーメッシュテクノロジー:電界紡糸法の生体材料設計への応用

    木戸秋悟、松田武久

    成形加工   2007.12

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 生体分子相互作用のエネルギーランドスケープ解析

    木戸秋悟、牧禎、松田武久

    高分子   2007.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Mechanistic aspects of protein/material interaction probed by AFM

    S. Kidoaki and T. Matsuda

    Colloids & Surfaces B: Biointerfaces   2002.1

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 長鎖DNAの構造をみる(蛍光顕微鏡)

    木戸秋悟、吉川研一

    高分子学会誌   1997.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 英語での文章表現を身につけるー英語論文を書くために

    木戸秋悟

    化学(化学同人)   1997.1

     More details

    Language:Japanese  

  • 巨大DNAの分子内相転移〜自己排除鎖と凝縮鎖

    木戸秋悟、吉川研一

    生物物理学会誌   1994.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • YAPとRUNX2の反応の不均一性に基づいた間葉系幹細胞培養基板の硬さのデザインに関するガイドライン(Guideline for design of substrate stiffness for mesenchymal stem cell culture based on heterogeneity of YAP and RUNX2 responses)

    Miyoshi Hiromi, Yamazaki Masashi, Fujie Hiromichi, Kidoaki Satoru

    Biophysics and Physicobiology   20 ( 2 )   e200018_1 - e200018_9   2023

     More details

    Language:English   Publisher:(一社)日本生物物理学会  

  • 細胞レベルで硬さが不均一な基材上での細胞の遊走、形状、牽引力の相互作用(Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity)

    Ebata Hiroyuki, Kidoaki Satoru

    Biophysics and Physicobiology   19   e190036_1 - e190036_16   2022

     More details

    Language:English   Publisher:(一社)日本生物物理学会  

▼display all

Industrial property rights

Patent   Number of applications: 10   Number of registrations: 2
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • International Society of Mechanobiology

  • バイオミメティックス研究会

  • 日本再生医療学会

  • Japanese Society for Medical and Biological Engineering

  • 細胞生物学会

  • 日本化学会

  • Biophysical Society

  • 生物物理学会

  • 高分子学会

  • 日本バイオマテリアル学会

  • 日本メカノバイオロジー学会

  • 日本分子生物学会

  • 高分子学会

      More details

  • 細胞生物学会

      More details

  • 生物物理学会

      More details

  • 日本化学会

      More details

  • 日本バイオマテリアル学会

      More details

▼display all

Committee Memberships

  • 日本メカノバイオロジー学会   Executive   Domestic

    2021.4 - 2022.3   

  • 日本生体医工学会   代議員   Domestic

    2018.5 - 2022.3   

  • 日本生物物理学会   分野別専門委員(E-19. 医用生体工学)   Domestic

    2017.1 - 2018.12   

  • 日本細胞生物学会   代議員   Domestic

    2016.6 - 2018.6   

  • 日本バイオマテリアル学会   Executive   Domestic

    2013.11 - 2015.11   

  • 日本機械学会   分科会委員(P-SCC12 高度物理刺激と生体応答に関する研究分科会)   Domestic

    2013.4 - 2015.3   

  • 高分子学会バイオミメティックス研究会   Steering committee member   Domestic

    2012.4 - Present   

  • 日本バイオマテリアル学会   Councilor   Domestic

    2012.4 - 2018.12   

  • 日本生物物理学会   分野別専門委員(D32 培養細胞)   Domestic

    2011.4 - Present   

▼display all

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

  • Screening of academic papers

    Role(s): Peer review

    2023

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • Screening of academic papers

    Role(s): Peer review

    2022

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:14

  • Screening of academic papers

    Role(s): Peer review

    2021

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:13

  • Screening of academic papers

    Role(s): Peer review

    2020

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:6

  • Screening of academic papers

    Role(s): Peer review

    2019

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

    Proceedings of International Conference Number of peer-reviewed papers:20

  • Screening of academic papers

    Role(s): Peer review

    2018

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:11

  • シンポジウムオーガナイザー

    第55回日本生物物理学会年会  ( Japan ) 2017.9

     More details

    Type:Competition, symposium, etc. 

    Number of participants:200

  • Screening of academic papers

    Role(s): Peer review

    2017

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:17

  • 日本学術振興会学術システム研究センター専門研究員(総合系専門調査班および医歯薬学専門調査班併任)

    Role(s): Review, evaluation

    独立行政法人日本学術振興会  2016.4 - 2019.3

     More details

    Type:Scientific advice/Review 

  • ISO/TC206バイオミメティックス国内審議委員会委員

    Role(s): Review, evaluation

    公益社団法人 高分子学会  2014.4 - 2016.3

     More details

    Type:Scientific advice/Review 

  • セッションオーガナイザー International contribution

    35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society  ( Osaka International Convention Center Japan ) 2013.7

     More details

    Type:Competition, symposium, etc. 

  • 物質・デバイス領域共同研究拠点 共同研究推進委員会委員

    Role(s): Review, evaluation

    大阪大学産業科学研究所  2012.4 - 2016.3

     More details

    Type:Scientific advice/Review 

  • オーガナイザー

    文部科学省 科学研究費補助金 「特定領域研究」 マルチスケール操作によるシステム細胞工学(バイオ操作) 第8回公開シンポジウム  ( Japan ) 2010.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:100

  • 物質・デバイス領域共同研究拠点 共同研究推進委員会委員

    Role(s): Review, evaluation

    大阪大学産業科学研究所  2009.11 - 2012.3

     More details

    Type:Scientific advice/Review 

  • 戦略的創造研究推進事業・CREST 研究領域「生命現象の解明と応用に資する新しい計測・分析基盤技術」中間評価/ 外部評価委員

    Role(s): Review, evaluation

    科学技術振興機構  2009.11

     More details

    Type:Scientific advice/Review 

  • セッションオーガナイザー

    第58回高分子討論会  ( Japan ) 2009.9

     More details

    Type:Competition, symposium, etc. 

  • 科学技術・学術審議会(学術分科会)/専門委員

    Role(s): Review, evaluation

    文部科学省  2008.1 - 2008.12

     More details

    Type:Scientific advice/Review 

  • 科学技術・学術審議会(学術分科会)/専門委員

    Role(s): Review, evaluation

    文部科学省  2006.2 - 2007.1

     More details

    Type:Scientific advice/Review 

  • 実行委員(企業後援・展示担当)

    ナノ学会第6回大会  ( Japan )

     More details

    Type:Competition, symposium, etc. 

▼display all

Research Projects

  • 高分子ナノ界面力学設計による長周期ゆらぎ増幅・治療効果増強幹細胞の製造基材開発

    Grant number:24H00802  2024.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    木戸秋 悟, 玉田 薫, 久保木 タッサニーヤー, 政池 彩雅

      More details

    Grant type:Scientific research funding

    本研究課題は、応募者の独自発明である「非一様力学場・非定住培養による細胞機能活性化・治療効果増強技術」(2023年日欧中3カ国で特許査定*。米豪印で審査中)の実用製品化展開を目指す上で、より汎用性・普及性の高いドライ高分子薄膜修飾基板への同技術原理の実装を目的とし、次の3点の課題に取り組む。1)細胞の伸縮接着モードを誘導する高分子薄膜のナノ力学設計、2)細胞の長周期ゆらぎ増幅とメカノ活性化を精密定量するウェーブレット解析評価指標開発、3)開発基材を用いた治療効果増強幹細胞製造のための非臨床POCの取得。

    CiNii Research

  • 中谷医工計測財団特別研究助成

    2023

      More details

    Grant type:Donation

  • エントロピー増大に逆らう革新材料「力学極性ゲル」による物質・エネルギー・生物の整流化

    2022.11 - 2028.3

    科学技術振興機構 

      More details

    Authorship:Coinvestigator(s) 

  • エントロピー増大に逆らう革新材料「力学極性ゲル」による物質・エネルギー・生物の整流化

    2022 - 2027

    JST-CREST

      More details

    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 微小管メカニクスが誘導する細胞極性パターニング

    Grant number:21KK0127  2021.10 - 2025.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    茂木 文夫, 西村 有香子, 木戸秋 悟, 柴田 達夫, 多羅間 充輔

      More details

    Grant type:Scientific research funding

    生体内の細胞は、その多くが分化に伴って非対称な極性パターンを獲得する。近年、細胞極性は細胞内で発生する機械的力刺激を必要とすることが示されたが、この過程で力刺激を感知・応答する仕組みは未だに不明な点が多い。本研究では、細胞骨格である「微小管」のメカニクスを中心とするメカノトランスダクション機構が、細胞スケールの極性パターンを誘導する分子機構を包括的に理解する。光遺伝学手法と細胞外基質の微細加工を利用した微小管メカニクスの人為的操作技術を確立し、微小管の高速高解像度ライブイメージングと画像解析・数理解析を融合した学際的研究戦略によって、細胞極性化における微小管メカニクスの生理的意義を解明する。

    CiNii Research

  • 細胞メカノ活性化効果を最適化する非一様力学場培養技術の開発

    Grant number:21K18326  2021 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Challenging Research(Pioneering)

    木戸秋 悟, 久保木 タッサニーヤー, 江端 宏之

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    本研究は、非一様力学場環境中を運動する細胞において顕現する、細胞の生存・増殖・運動性などの諸機能の増強現象に着目し、その系統的操作技術を開発し細胞操作工学の新たな基材設計分野を開拓することを目的とする。非一様力学場を非定住に運動する細胞では内部応力ゆらぎが増幅される結果、細胞の健常活動に関与する遺伝子群の発現が広範に活性化されることを我々はこれまでに独自に見出している。非一様力学場上での細胞の自発的運動は細胞内部応力の非平衡度の増大とともに細胞をより健常化し、その機能強化に寄与する(メカノ活性化効果)。本研究ではこの現象の系統的制御、原理解明、および実用展開の開拓に取り組む。

    CiNii Research

  • Super-resolution live-cell imaging of cell-attached nanointerface using LSPR sheets

    Grant number:19H05627  2019.6 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

    玉田 薫, 木戸秋 悟, 須川 晃資, 岡本 晃一, 居城 邦治

      More details

    Grant type:Scientific research funding

    AIを使った画像解析技術の飛躍的進歩は医療診断分野にパラダイムシフトを起こしつつある。大量の画像を高速で処置できるようになった今、次に必要とされるのは、高度情報処理技術に見合った高品質の画像情報である。我々は、独自技術である金属微粒子自己組織化により作製した「局在プラズモンシート」の光閉じ込めおよび蛍光増強効果により、ナノ界面(埋もれた界面)における生細胞の分子ダイナミクスを超解像度で高速イメージングできる技術開発を進めている。細胞接着界面における分子レベルでの反応を明らかにすることで、基礎生化学・医学的課題に対して新たな情報を提供することを目的とする。

    CiNii Research

  • 流動性足場・曲面足場設計に基づくオルガノイドの精密誘導技術の開発

    Grant number:18H04167  2018 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    木戸秋 悟

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    人工小臓器の芽構造であるオルガノイドを培養環境にて再現よく高効率に発生・誘導する技術と学理を開拓することを目的とし、オルガノイドの培養足場材料の粘弾性特性および形状誘導に係る曲面特性の各パラメーター効果を系統的に調べた。従来のオルガノイド作製で汎用されるマトリゲルのレオロジー特性を、追加架橋および機械的切断操作により調節しオルガノイド形成の最適動的粘弾性値を見出した。シンプルな合成高分子PEGにポリペプチドを修飾した物理架橋マトリックスを作製し、ラミニンを導入した系においてそれら粘弾性特性を設定することでマトリゲルの系よりも安定した肝オルガノイドの誘導に成功した。

    CiNii Research

  • AMED-CREST 『幹細胞の品質保持培養のためのメカノバイオマテリアルの開発』

    2015.12 - 2021.3

    国立研究開発法人日本医療研究開発機構(AMED) 

      More details

    Authorship:Principal investigator 

  • 幹細胞の品質保持培養のためのメカノバイオマテリアルの開発

    2015 - 2020

    革新的先端研究開発支援事業(AMED-CREST)

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 弾性パターニングゲルを用いたヒトiPS細胞のフィーダーフリー高速増殖技術の開発

    Grant number:15H03023  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 弾性率可変マイクロゲルファイバーマトリックスを用いた異種細胞の自発的機能的局在化

    Grant number:15K12513  2015 - 2016

    Grants-in-Aid for Scientific Research  Grant-in-Aid for challenging Exploratory Research

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 生物規範メカニクス・システム

    2012 - 2016

    Japan Society for the Promotion of Science・Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 分化フラストレーション誘導基材を用いた幹細胞の未分化維持大量培養技術の開発

    Grant number:24300173  2012 - 2014

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 力場ー化学場共役系における細胞運動制御 International coauthorship

    2010.8

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 附置研究所間アライアンスによる ナノとマクロをつなぐ物質・システム創製戦略プロジェクト (ナノマクロ物質・デバイス・システム創製アライアンス):G3 医療・デバイスシステム

    2010.4 - 2015.3

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 最先端研究開発支援プロジェクト 『一分子解析技術を基盤とした革新的ナノバイオデバイスの開発研究(川合最先端PJ)』

    2010.4 - 2014.3

      More details

    Authorship:Coinvestigator(s) 

  • 一分子解析技術を基盤とした革新的ナノバイオデバイスの開発研究

    2010 - 2013

    最先端研究開発支援プロジェクト(川合最先端PJ)

      More details

    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 幹細胞系統決定に関与する細胞内レドックスタンパク質の発現解析 International coauthorship

    2009.12

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 科学技術振興機構 さきがけ 『細胞運動・機能を操作するナノ・マイクロメカニカルシステムの構築 』

    2009.10 - 2013.3

      More details

    Authorship:Principal investigator 

  • 弾性基材を用いた幹細胞プロテオミクス解析 International coauthorship

    2009.1 - 2012.9

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 細胞運動・機能を操作するナノ・マイクロメカニカルシステムの構築

    2009 - 2012

    科学技術振興機構さきがけ研究

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 弾性基材表面への細胞接着力解析 International coauthorship

    2008.6

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 組織形成のメカノバイオロジーと機能組織のロボット加工技術

    Grant number:17076012  2005 - 2009

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Priority Areas

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 細胞外力学環境の微細設計と細胞のメカノタキシス制御のナノバイオメカニクス研究

    Grant number:17680038  2005 - 2007

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (A)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • ナノ・マイクロファイバー骨格基材の電界紡糸設計:コンプライアント人工血管への応用

    Grant number:16651068  2004

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Exploratory Research

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • ゲノムレベルのタンパク相互作用探索と医療に向けたナノレゴ開発(林崎CREST) 分担テーマ『リガンドーレセプタ力を活用したタンパク質分子のナノ秩序アーキテクチャー』

    2003 - 2007

    JST Strategic Basic Research Program (Ministry of Education, Culture, Sports, Science and Technology)

      More details

    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 細胞形態・機能調節のための細胞一材料相互作用のナノバイオメカニクス研究

    Grant number:15680015  2003 - 2004

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (A)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • エレクトロスピニングによるナノファイバー形成を応用した組織骨格基材の機能的設計

    Grant number:15651054  2003

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Exploratory Research

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 科学技術振興機構 戦略的基礎研究推進事業『ゲノムレベルの生体分子相互作用探索と医療に向けたナノレゴ開発』

    2002.11 - 2008.3

    科学技術振興機構 

      More details

    Authorship:Coinvestigator(s) 

  • 科学技術振興機構 戦略的基礎研究推進事業 『自己生成するナノ秩序体:高次構造制御と機能発現』

    1999.10 - 2004.3

    科学技術振興機構 

      More details

    Authorship:Coinvestigator(s) 

  • 自己生成するナノ秩序体:高次構造制御と機能発現(吉川CREST) 分担テーマ『高分子ナノ秩序体の光化学反応による構築と機能制御』

    1999 - 2004

    JST Strategic Basic Research Program (Ministry of Education, Culture, Sports, Science and Technology)

      More details

    Authorship:Coinvestigator(s)  Grant type:Contract research

▼display all

Class subject

  • 分子生命工学特論第九

    2024.4 - 2025.3   Full year

  • 応用化学実験第二

    2024.4 - 2024.9   First semester

  • 細胞操作工学特論

    2023.10 - 2024.3   Second semester

  • 細胞操作工学特論

    2023.10 - 2024.3   Second semester

  • Advanced Cell Manipulation Engineering

    2023.10 - 2024.3   Second semester

  • 超分子化学講究A

    2023.4 - 2024.3   Full year

  • 分子生命工学特論第九

    2023.4 - 2024.3   Full year

  • 物質科学研究企画演習

    2023.4 - 2024.3   Full year

  • 物質科学情報集約演習

    2023.4 - 2024.3   Full year

  • 生体工学特論

    2023.4 - 2023.9   First semester

  • 物質科学工学実験第二

    2023.4 - 2023.9   First semester

  • 細胞操作工学特論

    2022.10 - 2023.3   Second semester

  • 細胞操作工学特論

    2022.10 - 2023.3   Second semester

  • Advanced Cell Manipulation Engineering

    2022.10 - 2023.3   Second semester

  • 超分子化学講究A

    2022.4 - 2023.3   Full year

  • 分子生命工学特論第九

    2022.4 - 2023.3   Full year

  • 超分子化学講究A

    2022.4 - 2023.3   Full year

  • 物質科学研究企画演習

    2022.4 - 2023.3   Full year

  • 物質科学情報集約演習

    2022.4 - 2023.3   Full year

  • 物質科学工学実験第二

    2022.4 - 2022.9   First semester

  • 生体工学特論

    2022.4 - 2022.9   First semester

  • 細胞操作工学特論

    2021.10 - 2022.3   Second semester

  • Advanced Cell Manipulation Engineering

    2021.10 - 2022.3   Second semester

  • 分子細胞生物学Ⅱ

    2021.10 - 2022.3   Second semester

  • Molecular Cell Biology II

    2021.10 - 2022.3   Second semester

  • 超分子化学講究A

    2021.4 - 2022.3   Full year

  • 物質科学研究企画演習

    2021.4 - 2022.3   Full year

  • 物質科学情報集約演習

    2021.4 - 2022.3   Full year

  • 物質科学工学実験第二

    2021.4 - 2021.9   First semester

  • 生体工学特論

    2021.4 - 2021.9   First semester

  • 物理化学第一及び演習

    2021.4 - 2021.6   Spring quarter

  • 物理化学第一

    2021.4 - 2021.6   Spring quarter

  • 分子細胞生物学Ⅱ

    2020.10 - 2021.3   Second semester

  • Molecular Cell BiologyⅡ

    2020.10 - 2021.3   Second semester

  • 超分子化学講究A

    2020.4 - 2021.3   Full year

  • 物質科学研究企画演習

    2020.4 - 2021.3   Full year

  • 物質科学情報集約演習

    2020.4 - 2021.3   Full year

  • 物質科学工学実験第二

    2020.4 - 2020.9   First semester

  • 生体工学特論

    2020.4 - 2020.9   First semester

  • 物理化学第一

    2020.4 - 2020.6   Spring quarter

  • 物理化学第一及び演習

    2020.4 - 2020.6   Spring quarter

  • 分子細胞生物学Ⅱ

    2019.10 - 2020.3   Second semester

  • 分子細胞生物学Ⅱ

    2019.10 - 2020.3   Second semester

  • Molecular Cell Biology II

    2019.10 - 2020.3   Second semester

  • 超分子化学講究A

    2019.4 - 2020.3   Full year

  • 物質科学研究企画演習

    2019.4 - 2020.3   Full year

  • 物質科学情報集約演習

    2019.4 - 2020.3   Full year

  • 生体工学特論

    2019.4 - 2019.9   First semester

  • 物質科学工学実験第二

    2019.4 - 2019.9   First semester

  • 物理化学第一

    2019.4 - 2019.6   Spring quarter

  • 物理化学第一及び演習

    2019.4 - 2019.6   Spring quarter

  • 分子細胞生物学Ⅱ

    2018.10 - 2019.3   Second semester

  • Molecular Cell Biology II

    2018.10 - 2019.3   Second semester

  • 物質科学情報集約演習

    2018.4 - 2019.3   Full year

  • 物質科学研究企画演習

    2018.4 - 2019.3   Full year

  • 生体工学特論

    2018.4 - 2018.9   First semester

  • 物質科学工学実験第二

    2018.4 - 2018.9   First semester

  • 物理化学第一

    2018.4 - 2018.6   Spring quarter

  • 物理化学第一及び演習

    2018.4 - 2018.6   Spring quarter

  • 産学連携特論第四

    2017.10 - 2018.3   Second semester

  • Molecular Cell Biology II

    2017.10 - 2018.3   Second semester

  • 分子細胞生物学Ⅱ

    2017.10 - 2018.3   Second semester

  • 分子細胞生物学II

    2017.10 - 2018.3   Second semester

  • 物質科学研究企画演習

    2017.4 - 2018.3   Full year

  • 物質科学情報集約演習

    2017.4 - 2018.3   Full year

  • 生体工学特論

    2017.4 - 2017.9   First semester

  • 物質科学工学実験第二

    2017.4 - 2017.9   First semester

  • 産学連携特論第四

    2016.10 - 2017.3   Second semester

  • 物理化学第二及び演習

    2016.10 - 2017.3   Second semester

  • 分子細胞生物学II

    2016.10 - 2017.3   Second semester

  • 物質科学研究企画演習

    2016.4 - 2017.3   Full year

  • 物質科学情報集約演習

    2016.4 - 2017.3   Full year

  • 生体工学特論

    2016.4 - 2016.9   First semester

  • 物質科学工学実験第二

    2016.4 - 2016.9   First semester

  • 物質科学工学概論

    2015.10 - 2016.3   Second semester

  • 産学連携特論第四

    2015.10 - 2016.3   Second semester

  • 分子細胞生物学II

    2015.10 - 2016.3   Second semester

  • 物質科学研究企画演習

    2015.4 - 2016.3   Full year

  • 物質科学情報集約演習

    2015.4 - 2016.3   Full year

  • 生体工学特論

    2015.4 - 2015.9   First semester

  • 物質科学工学実験第二

    2015.4 - 2015.9   First semester

  • 物質科学工学概論

    2014.10 - 2015.3   Second semester

  • 分子細胞生物学II

    2014.10 - 2015.3   Second semester

  • 物質科学研究企画演習

    2014.4 - 2015.3   Full year

  • 物質科学情報集約演習

    2014.4 - 2015.3   Full year

  • 基礎物理化学第二及び演習

    2014.4 - 2014.9   First semester

  • 物質科学工学実験第二

    2014.4 - 2014.9   First semester

  • 生体工学特論

    2014.4 - 2014.9   First semester

  • 分子細胞生物学II

    2013.10 - 2014.3   Second semester

  • 物質科学研究企画演習

    2013.4 - 2014.3   Full year

  • 物質科学情報集約演習

    2013.4 - 2014.3   Full year

  • 物質科学工学実験第二

    2013.4 - 2013.9   First semester

  • 物質科学工学概論

    2013.4 - 2013.9   First semester

  • 生体工学特論

    2013.4 - 2013.9   First semester

  • 分子細胞生物学II

    2012.10 - 2013.3   Second semester

  • 物質科学情報集約演習

    2012.4 - 2013.3   Full year

  • 物質科学研究企画演習

    2012.4 - 2013.3   Full year

  • 基礎物理化学第二及び演習

    2012.4 - 2012.9   First semester

  • 物質科学工学実験第二

    2012.4 - 2012.9   First semester

  • 生体工学特論

    2012.4 - 2012.9   First semester

  • 物質科学工学概論

    2012.4 - 2012.9   First semester

  • 分子細胞生物学II

    2011.10 - 2012.3   Second semester

  • 物質科学情報集約演習

    2011.4 - 2012.3   Full year

  • 物質科学研究企画演習

    2011.4 - 2012.3   Full year

  • 物質科学工学概論

    2011.4 - 2011.9   First semester

  • 物質科学工学実験第二

    2011.4 - 2011.9   First semester

  • 生体工学特論

    2011.4 - 2011.9   First semester

  • 分子細胞生物学II

    2010.10 - 2011.3   Second semester

  • 物質科学情報集約演習

    2010.4 - 2011.3   Full year

  • 物質科学研究企画演習

    2010.4 - 2011.3   Full year

  • 基礎物理化学第二及び演習

    2010.4 - 2010.9   First semester

  • 物質科学工学実験第二

    2010.4 - 2010.9   First semester

  • 生体工学特論

    2010.4 - 2010.9   First semester

  • 物質科学工学概論

    2010.4 - 2010.9   First semester

  • 基礎化学熱力学

    2009.10 - 2010.3   Second semester

  • 物質科学情報集約演習

    2009.4 - 2010.3   Full year

  • 物質科学研究企画演習

    2009.4 - 2010.3   Full year

  • 分子細胞生物学II

    2009.4 - 2009.9   First semester

  • 物質科学工学実験第二

    2009.4 - 2009.9   First semester

  • 物質科学工学概論

    2009.4 - 2009.9   First semester

  • 分子細胞生物学II

    2008.10 - 2009.3   Second semester

  • 物質科学情報集約演習

    2008.4 - 2009.3   Full year

  • 物質科学研究企画演習

    2008.4 - 2009.3   Full year

  • 基礎物理化学第二および演習

    2008.4 - 2008.9   First semester

  • 物質科学工学概論

    2008.4 - 2008.9   First semester

  • 生命分子物理化学特論

    2007.10 - 2008.3   Second semester

  • 物質科学情報集約演習

    2007.4 - 2008.3   Full year

  • 物質科学研究企画演習

    2007.4 - 2008.3   Full year

  • 基礎化学熱力学

    2007.4 - 2007.9   First semester

▼display all

FD Participation

  • 2023.12   Role:Participation   Title:先導研FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.5   Role:Participation   Title:先導研FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.12   Role:Participation   Title:先導研FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.5   Role:Participation   Title:先導研FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.5   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.1   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.5   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.1   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.5   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.1   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.5   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.1   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.5   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.1   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2008.5   Role:Participation   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.4   Role:Participation   Title:第一回全学FD

    Organizer:University-wide

  • 2007.2   Role:Speech   Title:先導研FD研修会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2018  広島大学医歯薬学総合研究科  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2017  広島大学医歯薬学総合研究科  Classification:Affiliate faculty  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期/歯科理工学分担講義

  • 2016  広島大学医歯薬学総合研究科  Classification:Affiliate faculty  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期/歯科理工学分担講義

  • 2015  広島大学医歯薬学総合研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期/歯科理工学分担講義

  • 2014  広島大学医歯薬学総合研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期/歯科理工学分担講義

  • 2013  広島大学医歯薬学総合研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期/歯科理工学分担講義

  • 2013  京都大学再生医科学研究所  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期セミナー

  • 2012  京都大学再生医科学研究所  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期セミナー

  • 2012  広島大学医歯薬学総合研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期/歯科理工学分担講義

  • 2011  名古屋大学大学院工学研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期セミナー

  • 2011  京都大学再生医科学研究所  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期セミナー

  • 2011  広島大学医歯薬学総合研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:後期/歯科理工学分担講義

  • 2009  北陸先端科学技術大学院大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:マテリアルサイエンス研究科セミナー

  • 2009  広島大学大学院理学研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期 集中講義

▼display all

Other educational activity and Special note

  • 2011  Special Affairs  グローバルCOE未来分子システム科学 『先端生命科学特論』担当

     詳細を見る

    グローバルCOE未来分子システム科学 『先端生命科学特論』担当

  • 2010  Special Affairs  グローバルCOE未来分子システム科学 『先端生命科学特論』担当

     詳細を見る

    グローバルCOE未来分子システム科学 『先端生命科学特論』担当

  • 2009  Special Affairs  グローバルCOE未来分子システム科学 『先端生命科学特論』担当

     詳細を見る

    グローバルCOE未来分子システム科学 『先端生命科学特論』担当

  • 2008  Special Affairs  GCOE『未来分子システム科学』事業推進者

     詳細を見る

    GCOE『未来分子システム科学』事業推進者

  • 2008  Special Affairs  グローバルCOE未来分子システム科学 『先端生命科学特論』担当

     詳細を見る

    グローバルCOE未来分子システム科学 『先端生命科学特論』担当

Social Activities

  • 九州大学1日体験化学教室 第86回 化学への招待

    日本化学会九州支部・九州大学応用化学部門分子教室  九州大学伊都キャンパス  2015.12

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 九大百年まつり市民公開講座 文部科学省認定 全国共同利用・共同研究拠点セミナー/九大発!最先端のサイエンスー九州大学附属3研究所及び1センターから社会への新たなメッセージー 『細胞を操るー医用工学の挑戦ー』

    九州大学/先導物質化学研究所・生体防御医学研究所・応用力学研究所・情報基盤研究開発センター  九州大学伊都キャンパス  2012.5

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • ひらめき☆ときめきサイエンス&#12316;ようこそ大学の研究室へ&#12316; 『柔らかい材料 ソフトマテリアル』の化学 講師

    九州大学・日本学術振興会  九州大学箱崎キャンパス  2006.11

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Activities contributing to policy formation, academic promotion, etc.

  • 2016.4 - 2019.3   日本学術振興会

    H28〜H30にわたり、日本学術振興会学術システム研究センター専門研究員(工学系科学専門調査班および医歯薬学専門調査班併任) として、科学研究費補助金事業における人間医工学分野の審査運営に参画し、公正・厳正な科研費審査体制の保持・改善・拡充業務に貢献した。当該期間の専門研究員約100名のうち、工学系科学専門調査班および医歯薬学専門調査班を併任する唯一の研究員として、両班の業務に従事した。

Acceptance of Foreign Researchers, etc.

  • Chiang Mai University

    Acceptance period: 2013.1 - 2013.3   (Period):1 month or more

    Nationality:Thailand

    Business entity:Other

  • Chiang Mai University

    Acceptance period: 2010.3 - 2010.5   (Period):1 month or more

    Nationality:Thailand

    Business entity:Japan Society for the Promotion of Science