Updated on 2025/01/08

Information

 

写真a

 
TANAKA MASARU
 
Organization
Institute for Materials Chemistry and Engineering Department of Soft Materials Chemistry Professor
Graduate School of Engineering (Concurrent)
Graduate School of Engineering Department of Mechanical Engineering(Concurrent)
Title
Professor
Contact information
メールアドレス

Research Areas

  • Nanotechnology/Materials / Polymer chemistry

Degree

  • Ph.D

Research History

  • テルモ株式会社

    テルモ株式会社

  • 北海道大学 東北大学 山形大学

Research Interests・Research Keywords

  • Research theme:タンパク質吸着

    Keyword:タンパク質吸着

    Research period: 2024

  • Research theme:Biomaterials

    Keyword:Biomaterials

    Research period: 2024

  • Research theme:バイオ界面

    Keyword:バイオ界面

    Research period: 2024

  • Research theme:中間水

    Keyword:中間水

    Research period: 2024

  • Research theme:Medical devices

    Keyword:Medical devices

    Research period: 2024

  • Research theme:生体親和性

    Keyword:生体親和性

    Research period: 2024

  • Research theme:Interfacial water

    Keyword:Interfacial water

    Research period: 2024

  • Research theme:Cell adhesion

    Keyword:Cell adhesion

    Research period: 2024

  • Research theme:Polymer

    Keyword:Polymer

    Research period: 2024

  • Research theme:高分子合成

    Keyword:高分子合成

    Research period: 2024

  • Research theme:Design of biocompatible soft-biomaterials for medical devices

    Keyword:Biocompatibility, Cell adhesion, Bio-interfaces, Water structure, Medical devices

    Research period: 2015.3 - 2025.12

Awards

  • https://www.soft-material.jp/achievement/awards

    2024.3  

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    Fellow of Biomaterials Science and Engineering (FBSE)

  • JHeC 2022 アイディアコンテスト部門ファイナリスト 優秀賞

    2022.1  

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    当研究室の中間水コンセプトによる医療製品創出に関するアイディアが、経済産業省 主催のJHeC 2022 で優秀賞および特別賞を受賞した。
    https://www.soft-material.jp/information/news/article-4446

  • 学会賞

    2021.11   日本バイオマテリアル学会  

  • Kawasaki Deep Tech Accelerator 賞

    2021.8  

  • 日本バイオマテリアル学会 学会賞

    2021.7   日本バイオマテリアル学会   中間水コンセプトによるバイオイナート材料の設計

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    医療材料に関する世界初の設計指針を創成した。

  • 優秀賞

    2021.3   日本対がん協会福岡支部 がん研究助成金   細胞膜上の水和水に着目した癌細胞認識性リガンドの確立

  • 奨励賞

    2020.12   第30回日本MRS年次大会   Synthesis of Silsesquioxane/poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombogenicity and Vascular Endothelial Cell Adhesiveness

  • Award For Poster Presentation

    2019.11   China-Japan Biopolymer Symposium (1)  

  • Award For Poster Presentation

    2019.11   China-Japan Biopolymer Symposium  

  • 市村学術賞功績賞

    2019.4  

  • 第51回市村学術賞功績賞

    2019.4   公益財団法人 市村清新技術財団   医療来分子の開発と生体親和性発現機構の解明

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    医療高分子が血液などの生体成分に接触すると、異物反応が進行し不具合が生じる。病気の治療や超早期診断など、高齢社会においてニーズの大きい健康・医療技術や製品の開発には、製品性能を決定付ける製品の表面を形成する医療高分子の安全性と機能の向上が欠かせない。
    受賞者らは、合成高分子であるpoly(2-methoxyethyl acrylate)(PMEA)が、中間水(材料表面に緩やかに結合した水分子)を豊富に含む材料表面を作り出し、この中間水がタンパク質や細胞などの吸着を防ぐことを示してきた。PMEAコーティング技術は、研究支援機器、医療機器として実用化され、厚生労働省の認可を受けている。例えば、PMEAコーティング人工心肺は世界No.1のシェアを取り続けているなど、我が国発の世界に誇る実績を有している。これにより、我が国の研究開発総合力のプレゼンス向上に貢献した。
    一般に、合成高分子が生体に接触すると、直ちに水分子が材料表面に吸着する。吸着した水分子は、以下の2種類に分けられる。材料に強く結合し分子運動性が低下した不凍水と材料に弱く結合し分子運動性が高い自由水である。さらに、自由水と不凍水の中間的な性質を示す中間水が形成される。この中間水が生体親和性の発現に大きな影響を与えることが明らかにし、中間水に着目した生体親和性材料のスクリーニングにつながる「中間水コンセプト」を世界で初めて見出した。この中間水は、生体親和性を示す合成高分子と生体分子に共通して観測されることを見出した(図1)。
    また、受賞者らは、独自に設計したPMEA誘導体により適切な中間水量を与えると、血球細胞などの血栓を作る生体成分の吸着は抑制されたまま、がん細胞が選択的に接着することを見出し、基本特許を取得した。がん細胞をダメージレスに分離回収可能なので、分離回収した癌細胞を培養し、抗がん剤の評価が可能となった。受賞者らが見出した合成高分子への生体成分の吸着性を制御可能な中間水のコンセプトは、新世代医療高分子開発に大きく貢献した。

  • 第28回日本MRS年次大会奨励賞

    2018.12   Analysis of intemediate water by Soft X-ray absorption/emission and Terahertz spectroscopy

  • Biomaterials lnternatiomal 2017 Best Poster Paper Award

    2017.8   Biomaterials lnternatiomal  

  • International Association of Advanced Materials Scientists Award for the year 2016

    2016.4   International Association of Advanced Materials Scientists Award for the year 2016

  • International Association of Advanced Materials Scientists Award for the year 2016 (IAAM SA-2016)

    2016.3   International Association of Advanced Materials  

  • 9th World Biomaterials Congress Poster Award

    2012.6  

  • JSPN-NRF Asian Science Seminar Seoul, Encouraging Prize

    2012.2  

  • 高分子学会旭化成賞

    2011.10   高分子学会  

  • 高分子学会旭化成賞

    2011.9  

  • 日本バイオマテリアル学会科学奨励賞

    2009.11  

  • AAP Winner, 米国歯周病学会

    2009.9  

  • IUMRS-ICA2008 and MRS-J Encouraging Prize

    2008.12  

  • PMI2 Connect-Research Co-operation Award 2008 from British Council

    2008.6  

  • Nano tech 2007 国際ナノテクノロジー総合展・技術会議 Nano tech 大賞 バイオテクノロジー部門

    2007.12  

  • 日本人工臓器学会第44回オリジナル賞

    2007.11  

  • 日本表面科学会 平成19年度論文賞

    2007.11  

  • 日本化学会若い世代の特別講演会賞

    2007.7  

  • 日刊工業新聞第2回ものづくり連携大賞

    2007.2  

  • 日本化学会北海道支部奨励賞

    2007.2  

  • 高分子研究奨励賞

    2005.5  

  • 日本再生医療学会総会「優秀演題賞」

    2004.6  

  • 第83日本化学会春季年会2003 「講演奨励賞」受賞

    2003.3  

  • 応用物理学会講演奨励賞

    2002.9  

  • 第81日本化学会春季年会2002 「講演奨励賞」受賞

    2002.3  

  • Korea Japan Joint Forum KJF2001 Organic Materials for Electronics and Photonics, Best Poster Award

    2001.9  

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Papers

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface Reviewed International journal

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   4 ( 5 )   1591 - 1597   2018.5

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    DOI: 10.1021/acsbiomaterials.8b00081

  • Poly(ω-methoxyalkyl acrylate)s Nonthrombogenic Polymer Family with Tunable Protein Adsorption Reviewed International journal

    18 ( 12 )   4214 - 4223   2017.12

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    A series of polyacrylates with different n-alkyl side chain lengths (1 to 6, and 12 carbons) and a ω-methoxy terminal group (poly(ω-methoxyalkyl acrylate): PMCxA) were prepared to study their nonthrombogenicity using human platelet adhesion, micro bicinchoninic acid (micro BCA) protein assay, and enzyme-linked immunosorbent assay (ELISA) tests. In all cases, human platelet adhesion was suppressed on the PMCxA-coated substrates, and the number of human platelets adhered to the PMC3A (poly(3-methoxypropyl acrylate))-coated surface was comparable to that of commercialized nonthrombogenic coating agent poly(2-methoxyethyl acrylate) (PMEA, equal to PMC2A). The amount of protein adsorbed onto the PMCxA was investigated by micro BCA using bovine serum albumin (BSA) and human fibrinogen (hFbn), revealing that PMC3A exhibited significantly high resistance to nonspecific BSA adsorption. Additionally, the amount of hFbn adsorbed onto the PMC3A was suppressed to the same extent as PMEA. The exposure degree of platelet adhesion sites in adsorbed hFbn was evaluated using an ELISA test, and the degree on the PMCxA with three to six methylene carbons was comparable to the PMEA. The hydration water structure in the hydrated PMCxA was also characterized using differential scanning calorimetry (DSC). The amount of intermediate water, which is the hydration water molecules that moderately interact with the polymer matrix, was maximum in the PMEA with two methylene run lengths, whereas the amount decreased by increasing the number of methyelnes in the side chain. The amount of adsorbed protein increased with a decrease in the amount of intermediate water, suggesting that the protein adsorption amount is tunable by simply changing the number of methylene carbons in the side chain. The present study revealed that poly(ω-methoxyalkyl acrylate)s are useful for blood-contacting medical devices, and PMC3A is the best mode of PMCxA to apply as an antiprotein adsorption coating agent.

    DOI: 10.1021/acs.biomac.7b01247

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion A Promising Material for Resorbable Vascular Grafts and Stents Reviewed International journal

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    Biomacromolecules   18 ( 11 )   3834 - 3843   2017.11

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    DOI: 10.1021/acs.biomac.7b01210

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester) A Candidate for Blood-Compatible Polymers Reviewed International journal

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    Biomacromolecules   18 ( 5 )   1609 - 1616   2017.5

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    DOI: 10.1021/acs.biomac.7b00221

  • Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces Reviewed International journal

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   2 ( 12 )   2122 - 2126   2016.12

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    DOI: 10.1021/acsbiomaterials.6b00415

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption-Suppressing Poly(2-methoxyethyl acrylate) Analogs Reviewed International journal

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    Biomacromolecules   17 ( 11 )   3808 - 3815   2016.11

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    DOI: 10.1021/acs.biomac.6b01340

  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene Reviewed International journal

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   49 ( 21 )   8154 - 8161   2016.11

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    DOI: 10.1021/acs.macromol.6b01829

  • Regioselective Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side Chains. Reviewed International journal

    Shingo Kobayashi, Kousaku Fukuda, Maiko Kataoka, Masaru Tanaka

    Macromolecules   49 ( 7 )   2493 - 2501   2016.4

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    DOI: 10.1021/acs.macromol.6b00273

  • Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development Reviewed International journal

    Takashi Hoshiba, Takayuki Otaki, Eri Nemoto, Hiroka Maruyama, Masaru Tanaka

    ACS applied materials & interfaces   7 ( 32 )   18096 - 18103   2015.8

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    DOI: 10.1021/acsami.5b05210

  • Evaluation of Factors To Determine Platelet Compatibility by Using Self-Assembled Monolayers with a Chemical Gradient Reviewed International journal

    Taito Sekine, Yusaku Tanaka, Chikako Sato, Masaru Tanaka, Tomohiro Hayashi

    Langmuir   31 ( 25 )   7100 - 7105   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.langmuir.5b01216

  • Effect of local chain dynamics on a bioinert interface Reviewed International journal

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Tomoyasu Hirai, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    Langmuir   31 ( 12 )   3661 - 3667   2015.3

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    DOI: 10.1021/acs.langmuir.5b00258

  • Effect of sodium chloride on hydration structures of PMEA and P(MPC- R -BMA) Reviewed International journal

    Shigeaki Morita, Masaru Tanaka

    Langmuir   30 ( 35 )   10698 - 10703   2014.9

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    DOI: 10.1021/la502550d

  • Characterization of the attachment mechanisms of tissue-derived cell lines to blood-compatible polymers Reviewed International journal

    Takashi Hoshiba, Mayo Nikaido, Masaru Tanaka

    Advanced Healthcare Materials   3 ( 5 )   775 - 784   2014.6

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    DOI: 10.1002/adhm.201300309

  • How the brain differentiates human and monkey faces: Neuromagnetic evidence from spatiotemporal dynamics.

    Yamada E, Takeda A, Nakazono H, Tanaka M, Ogata K, Tobimatsu S

    Neuroscience   565   80 - 90   2025.1   ISSN:0306-4522

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  • Self-Assembly and Drug Encapsulation Properties of Biocompatible Amphiphilic Diblock Copolymers

    Kaito Yokota, Sari Usuda, Tomoya Nishimura, Rintaro Takahashi, Yusuke Taoka, Shingo Kobayashi, Masaru Tanaka, Kazuaki Matsumura, Shin-Ichi Yusa

    Langmuir   2025.1   ISSN:0743-7463

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    DOI: 10.1021/acs.langmuir.4c04048

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  • Relationship between maternal egg consumption during lactation and the risk of developing egg allergies in 12-month-old infants: A multicenter cohort study.

    Kishino S, Yonezawa K, Haruna M, Usui Y, Sasaki S, Fujita M, Matsuzaki M, Sato Y, Suetsugu Y, Ohori R, Tanaka M, Aoyama S

    Japan journal of nursing science : JJNS   22 ( 1 )   e12631   2025.1   ISSN:1742-7932

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    DOI: 10.1111/jjns.12631

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  • Preventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice.

    Li X, Ichiba Y, Watanabe T, Yoshino A, Cheng L, Nagasato Y, Takata F, Dohgu S, Iwasaki K, Tanaka M, Matsui T

    NPJ science of food   8 ( 1 )   114   2024.12

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    DOI: 10.1038/s41538-024-00360-0

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  • Association between early anti-cytomegalovirus therapy and the incidence of chronic graft-versus-host disease.

    Miyao K, Murata M, Nishida T, Ozawa Y, Uchida N, Fukuda T, Doki N, Eto T, Kawakita T, Mori Y, Takada S, Ohigashi H, Tanaka M, Kanda Y, Matsuoka KI, Ishimaru F, Atsuta Y, Kanda J, Terakura S, GVHD Working Group of the Japanese Society for Transplantation and Cellular Therapy

    International journal of hematology   2024.11   ISSN:0925-5710

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    DOI: 10.1007/s12185-024-03871-4

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  • B(12)-Catalyzed Carbonylation of Carbon Tetrahalides: Using a Broad Range of Visible Light to Access Diverse Carbonyl Compounds.

    Shichijo K, Tanaka M, Kametani Y, Shiota Y, Fujitsuka M, Shimakoshi H

    Chemistry (Weinheim an der Bergstrasse, Germany)   e202403663   2024.11   ISSN:0947-6539

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    DOI: 10.1002/chem.202403663

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  • Comparative outcomes of various transplantation platforms, highlighting haploidentical transplants with post-transplantation cyclophosphamide for adult T-cell leukaemia/lymphoma.

    Yoshimitsu M, Tanaka T, Nakano N, Kato K, Muranushi H, Tokunaga M, Ito A, Ishikawa J, Eto T, Morishima S, Kawakita T, Itonaga H, Uchida N, Tanaka M, Akizuki K, Ishitsuka K, Ohigashi H, Ota S, Ando T, Kanda Y, Fukuda T, Atsuta Y, Fuji S, ATL Working Group of the Japanese Society for Transplantation and Cellular Therapy

    British journal of haematology   2024.10   ISSN:0007-1048

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    DOI: 10.1111/bjh.19835

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  • The efficacy of wrapping with polyglycolic acid mesh and fibrin glue in preventing clinically relevant pancreatic fistula after minimally invasive distal pancreatectomy (WRAP Study): study protocol for a multicenter randomized controlled trial in Japan.

    Baba H, Oba A, Tanaka K, Miura T, Ban D, Edanami M, Ishikawa Y, Ohgi K, Tanaka H, Shintakuya R, Ikenaga N, Ijichi T, Kiya Y, Muranushi R, Yamaki S, Miyazaki N, Takeuchi S, Aoki S, Mizui T, Tanaka M, Ueda H, Dei H, Takami H, Okada K, Nakata K, Mataki Y, Osakabe H, Shibuya K, Hashimoto D, Inoue Y, Hirano S, Unno M, Esaki M, Kitago M, Akahoshi K, Sugiura T, Ebata T, Uemura K, Nakamura M, Otsuka T, Nagakawa Y, Fujii T, Satoi S, Takahashi Y

    BMC surgery   24 ( 1 )   314   2024.10

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    DOI: 10.1186/s12893-024-02610-0

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  • Dermoscopic Examination of Tinea Nigra on the Plantar Foot Unveils a Parallel Ridge Pattern Mimicking Acral-Lentiginous Melanoma(タイトル和訳中)

    Saikawa Mako, Kimura Utako, Ikari Yuka, Miyata Ayaka, Kaneko Takahide, Hiruma Masataro, Yaguchi Takashi, Tanaka Masaru, Takamori Kenji, Suga Yasushi

    Medical Mycology Journal   65 ( 4 )   103 - 106   2024.10   ISSN:2185-6486

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    Language:English   Publisher:(一社)日本医真菌学会  

  • A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome. International journal

    Mazaya Najmina, Shingo Kobayashi, Rena Shimazui, Haruka Takata, Mayuka Shibata, Kenta Ishibashi, Hiroshi Kamizawa, Akihiro Kishimura, Yoshihito Shiota, Daichi Ida, Taro Shimizu, Tatsuhiro Ishida, Yoshiki Katayama, Masaru Tanaka, Takeshi Mori

    Pharmaceutics   16 ( 10 )   2024.9   ISSN:1999-4923

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    Background: Acrylamide polymers with zwitterionic carboxybetaine (CB) side groups have attracted attention as stealth polymers that do not induce antibodies when conjugated to proteins. However, they induce antibodies when modified onto liposomes. We hypothesized that antibodies are produced against polymer backbones rather than CB side groups. Objectives: In this study, we designed and synthesized a polymer employing CB in its main chain, poly(N-acetic acid-N-methyl-propyleneimine) (PAMPI), and evaluated the blood retention of PAMPI-modified liposomes in mice. Results: The non-fouling nature of PAMPI-modified liposomes estimated from serum protein adsorption was found to be not inferior to PCB- and PEG-modified liposomes. However, to our surprise, the PAMPI-modified liposomes showed an instantaneous clearance less than 1 h post-injection, comparable to the naked liposomes. Conclusions: The extent of the blood retention of polymer-modified liposomes cannot be predicted by their susceptibility to serum protein adsorption and semi-flexible conformation.

    DOI: 10.3390/pharmaceutics16101271

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  • Pronounced Cold Crystallization and Hydrogen Bonding Distortion of Water Confined in Microphases of Double Zwitterionic Block Copolymer Aqueous Solutions

    Yuji Higaki, Takumi Masuda, Shohei Shiomoto, Yukiko Tanaka, Hisao Kiuchi, Yoshihisa Harada, Masaru Tanaka

    Langmuir   40 ( 37 )   19612 - 19618   2024.9   ISSN:07437463

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    DOI: 10.1021/acs.langmuir.4c02254

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  • Relation between the Water Content and Mechanical Properties of Hydrogels with Movable Cross-Links

    Koki Nishida, Ryohei Ikura, Kenji Yamaoka, Osamu Urakawa, Takashi Konishi, Tadashi Inoue, Go Matsuba, Masaru Tanaka, Yoshinori Takashima

    Macromolecules   2024.8   ISSN:0024-9297 eISSN:1520-5835

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.macromol.4c00732

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  • Water-Mediated On-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions

    Okada M., Xie S.C., Kobayashi Y., Yanagimoto H., Tsugawa D., Tanaka M., Nakano T., Fukumoto T., Matsumoto T.

    Advanced Healthcare Materials   13 ( 19 )   e2304616   2024.7   ISSN:21922640

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    Language:English   Publisher:Advanced Healthcare Materials  

    Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.

    DOI: 10.1002/adhm.202304616

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  • Rotational Dynamics of Water near Osmolytes by Molecular Dynamics Simulations

    Yuji Higuchi, Md. Abu Saleh, Takahisa Anada, Masaru Tanaka, Mafumi Hishida

    The Journal of Physical Chemistry B   128 ( 20 )   5008 - 5017   2024.5   ISSN:15206106

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    DOI: 10.1021/acs.jpcb.3c08470

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  • Regulating tumor innervation by nanodrugs potentiates cancer immunochemotherapy and relieve chemotherapy-induced neuropathic pain

    Shuting Zuo, Zhenyu Wang, Xiaoman Jiang, Yuewu Zhao, Panyue Wen, Jine Wang, Junjie Li, Masaru Tanaka, Shao Dan, Yan Zhang, Zheng Wang

    Biomaterials   309   122603 - 122603   2024.5   ISSN:0142-9612

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    Language:Others   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.biomaterials.2024.122603

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  • Development of stealth nanoparticles coated with poly(2-methoxyethyl vinyl ether) as an alternative to poly(ethylene glycol)

    Fujiura K., Naito M., Tanaka Y., Tanaka M., Nakanishi Y., Ejima H., Negishi L., Kujirai T., Kurumizaka H., Ohta S., Miyata K.

    Journal of Applied Polymer Science   141 ( 11 )   2024.3   ISSN:00218995

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    Poly(ethylene glycol) (PEG) modification, also known as PEGylation, has been extensively used to improve the stability of nanoparticles for nanomedical applications. However, PEG exhibits antigenicity in some formulations, motivating researchers to explore alternative polymers. Herein, poly(vinyl ether) (PVE) derivatives are highlighted as promising alternatives to PEG because they form intermediate water molecules that suppress non-specific protein adsorption and platelet adhesion to the material surface. We prepared a water-soluble PVE derivative, poly(2-methoxyethyl vinyl ether) (PMOVE), and utilized it as a surface modifier for gold nanoparticles (AuNPs) as model nanoparticles. PMOVE with a thiol terminus was synthesized and confirmed to form an intermediate water molecule using differential scanning calorimetry. Similar to the synthesis of PEGylated AuNPs (PEG-AuNPs), PMOVE-modified AuNPs (PMOVE-AuNPs) were successfully fabricated with an appreciably high density of PMOVE palisades via a thiol-gold coordination reaction. Similar to PEG-AuNPs, PMOVE-AuNPs showed reduced serum protein adsorption and prolonged blood circulation. Additionally, no significant cytotoxicity was observed after incubation of a murine macrophage cell line, RAW264.7, with PMOVE-AuNPs. Our results indicate that the PMOVE modification increases the stealthiness of nanoparticles that is equivalent to that achieved by PEGylation.

    DOI: 10.1002/app.55044

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  • Detailed dynamical features of the slow hydration water in the vicinity of poly(ethylene oxide) chains

    T. Kikuchi, T. Tominaga, D. Murakami, N. R. de Souza, M. Tanaka, H. Seto

    The Journal of Chemical Physics   160 ( 6 )   2024.2   ISSN:0021-9606 eISSN:1089-7690

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    Poly(ethylene oxide) (PEO) is a well-known biocompatible polymer and has widely been used for medical applications. Recently, we have investigated the dynamic behavior of hydration water in the vicinity of PEO chains at physiological temperature and shown the presence of slow water with diffusion coefficient one order of magnitude less than that of bulk water. This could be evidence for the intermediate water that is critical for biocompatibility; however, its detailed dynamical features were not established. In this article, we analyze the quasi-elastic neutron scattering from hydration water through mode distribution analysis and present a microscopic picture of hydration water as well as its relation to cold crystallization.

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  • Hydrolyzable and biocompatible aliphatic polycarbonates with ether-functionalized side chains attached via amide linkers

    Kazuki Fukushima, Shunta Hakozaki, Rongjian Lang, Yuta Haga, So Nakai, Atsushi Narumi, Masaru Tanaka, Takashi Kato

    Polymer Journal   56 ( 4 )   431 - 442   2024.1   ISSN:0032-3896 eISSN:1349-0540

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    Abstract

    Investigating polymer degradation mechanisms enables the establishment of controlled degradation techniques for the development of sustainable and recyclable materials. Hydration can play a crucial role in controlling the hydrolysis of polymers. Here, ether-functionalized aliphatic polycarbonates (APCs) susceptible to nonenzymatic hydrolysis were developed for application as biocompatible biomaterials. Among these polymers, those grafted with 2-methoxyethyl and 3-methoxypropyl side chains via an amide group were highly wettable, strongly interacted with water, and experienced almost complete hydrolysis in phosphate-buffered saline over 30 days, which was attributed to the hydrogen bonding between water and the amide/methoxy groups. In an alkaline medium, all amide-linked APCs were completely hydrolyzed within 30 days, regardless of the side-chain structure. In contrast, the nonamide-linked APCs and a representative aliphatic polycarbonate, poly(trimethylene carbonate), were minimally degraded in the buffer and experienced <31% degradation under alkaline conditions. The APC with the 3-methoxypropyl side chain exhibited platelet adhesion properties comparable to those of ether-functionalized APCs previously reported as blood-compatible polymers. Thus, our results demonstrate the effects of an amide linker on the hydration and hydrolytic properties of APCs and can help establish new design concepts for degradable polymers.

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  • Suspension Culture System for Isolating Cancer Spheroids using Enzymatically Synthesized Cellulose Oligomers. International journal

    Natsuki Hayakawa, Masahito Nishiura, Takahisa Anada, Shingo Kobayashi, Toshiki Sawada, Takeshi Serizawa, Masaru Tanaka

    ACS applied bio materials   7 ( 1 )   306 - 314   2024.1

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    Isolating cancer cells from tissues and providing an appropriate culture environment are important for a better understanding of cancer behavior. Although various three-dimensional (3D) cell culture systems have been developed, techniques for collecting high-purity spheroids without strong stimulation are required. Herein, we report a 3D cell culture system for the isolation of cancer spheroids using enzymatically synthesized cellulose oligomers (COs) and demonstrate that this system isolates only cancer spheroids under coculture conditions with normal cells. CO suspensions in a serum-containing cell culture medium were prepared to suspend cells without settling. High-purity cancer spheroids could be separated by filtration without strong stimulation because the COs exhibited antibiofouling properties and a viscosity comparable to that of the culture medium. When human hepatocellular carcinoma (HepG2) cells, a model for cancer cells, were cultured in the CO suspensions, they proliferated clonally and efficiently with time. In addition, only developed cancer spheroids from HepG2 cells were collected in the presence of normal cells by using a mesh filter with an appropriate pore size. These results indicate that this approach has potential applications in basic cancer research and cancer drug screening.

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  • Role of intermediate water in alleviating postsurgical intrapericardial adhesion

    Suzuki T., Konishi H., Suzuki A., Katsumata T., Fukuda Y., Miyamoto K., Ise T., Tanaka Y., Yamamoto A., Wen P., Shiomoto S., Tanaka M., Nemoto S.

    Surgery Today   2024   ISSN:09411291

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    Purpose: Various polymers have been used as postsurgical antiadhesive materials; however, the mechanisms underlying their efficacy remain unclear. Intermediate water has been found to prevent the adhesion between polymer molecules and proteins or cells. The present study investigated the role of intermediate water retained in the polymer in alleviating postsurgical pericardial adhesion. Methods: Hydrophobic fabrics were prepared using biodegradable polyglycolic acid. To add intermediate water, the fabric fibers were coated with poly(oxyethylene)oleyl ethers. Intermediate water in the hydrated state was detected by a thermal analysis for each material, and cell attachment to the fibers with or without coating was observed in vitro. Using a canine model of postsurgical pericardial adhesion, the severity of adhesion was examined along with a histological assessment during treatment, with or without fabric coating. Results: Intermediate water was detected in the coating materials but not in polyglycolic acid. Coating significantly reduced the cell attachment to the fibers. Coating also alleviated adhesion by reducing inflammation in the fibrous layer and replacing the fabric and granulomas that develop around the surgical sutures in the pericardial space. Conclusions: Intermediate water in the hydrated polymer of anti-adhesives may play an important role in alleviating postoperative pericardial adhesion.

    DOI: 10.1007/s00595-024-02953-4

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  • Neurophysiological markers of early cognitive decline in older adults: a mini-review of electroencephalography studies for precursors of dementia.

    Tanaka M, Yamada E, Mori F

    Frontiers in aging neuroscience   16   1486481   2024   ISSN:1663-4365

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    DOI: 10.3389/fnagi.2024.1486481

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  • Effects of Hydration Water on Bioresponsiveness of Polymer Interfaces Revealed by Analysis of Linear and Cyclic Polymer–Grafted Substrates

    Shin-nosuke Nishimura, Naoya Kurahashi, Shohei Shiomoto, Yoshihisa Harada, Masaru Tanaka

    Soft Matter   20 ( 47 )   9454 - 9463   2024   ISSN:1744-683X eISSN:1744-6848

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    Given that the hydration water of polymer matrices may differ from that of outermost polymer surfaces, processes at biomaterial–biofluid interfaces and role of hydration water therein cannot be adequately examined...

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  • Optically Transparent and Color-Stable Elastomer with Structural Coloration under Elongation

    Miyake D., He J., Asai F., Hara M., Seki T., Nishimura S.N., Tanaka M., Takeoka Y.

    Langmuir   39 ( 49 )   17844 - 17852   2023.12   ISSN:07437463

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    Optically transparent and colored elastomers with high toughness are expected to play an important role in the construction of advanced medical materials, wearable displays, and soft robots. In this study, we found that composite elastomers consisting of amorphous SiO2 particles homogeneously dispersed in high concentrations within a biocompatible acrylic polymer network exhibit optical transparency and bright structural colors. In the composite elastomers, the system in which the SiO2 particles form a colloidal amorphous array hardly changes its structural color hue despite deformation due to elongation. Furthermore, the composite elastomer of the SiO2 particles with the acrylic polymer network also results in high mechanical toughness. In summary, we have shown that the elastomer that exhibits fade-resistant structural coloration formed from safe materials can combine stable coloration and mechanical strength independent of their shape. This is expected to have new potential in future technologies to support our daily life.

    DOI: 10.1021/acs.langmuir.3c02442

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  • Design of cell adhesive/non-adhesive synthetic polymers by controlling the nanobiointerfacial water

    Tanaka Masaru

    Drug Delivery System   38 ( 5 )   404 - 415   2023.11   ISSN:09135006 eISSN:18812732

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    When materials come into contact with biological fluids, water immediately adsorb onto the surface of materials. Water molecules play a crucial role in nanobiointerfacial interactions, including protein adsorption/desorption and cell adhesion/deadhesion on materials. To understand the role of water in the interaction of proteins and cells at biological interfaces, it is important to compare particular states of hydration water with various physicochemical properties of hydrated materials. Here, we discuss the fundamental concepts for determining the interactions of proteins and cells with hydrated materials along with selected examples corresponding to our recent studies, poly(2-methoxyethyl acrylate) (PMEA), PMEA derivatives, zwitterionic polymers, poly(ethylene glycol), and poly(2-oxazoline)s, and other polymers including biopolymers (DNA, RNA, proteins, and polysaccharides). The states of water were analyzed by differential scanning calorimetry, time-resolved <i>in situ</i> attenuated total reflection infrared spectroscopy, solid-states NMR, surface force measurements, and wide variety of analytical techniques. We found that intermediate water which is loosely bound to a polymer, is a useful indicator of the biocompatibility of polymer surfaces. This finding on intermediate water provides novel insights and helps develop novel experimental models for understanding protein adsorption/cell adhesion in a wide range of polymers, and helps guiding principles to design functional polymers such as those used in biomedical applications.

    DOI: 10.2745/dds.38.404

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  • Assessing the variability of tissue-free water tritium and non-exchangeable organically bound tritium in pine needles in Fukushima using atmospheric titrated water vapor.

    Hirao S, Kakiuchi H, Akata N, Tamari T, Sugihara S, Shima N, Tanaka M

    The Science of the total environment   168173   2023.10   ISSN:0048-9697

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    DOI: 10.1016/j.scitotenv.2023.168173

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  • Altering the bio-inert properties of surfaces by fluorinated copolymers of mPEGMA

    Ryohei Koguchi, Katja Jankova, Yukiko Tanaka, Aki Yamamoto, Daiki Murakami, Qizhi Yang, Bruno Ameduri, Masaru Tanaka

    Biomaterials Advances   153   213573 - 213573   2023.10   ISSN:2772-9508 eISSN:2772-9508

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    DOI: 10.1016/j.bioadv.2023.213573

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  • Organocatalyzed ring-opening reactions of γ-carbonyl-substituted ε-caprolactones

    Takayuki Ota, Valentina Montagna, Yuji Higuchi, Takashi Kato, Masaru Tanaka, Haritz Sardon, Kazuki Fukushima

    RSC Advances   13 ( 40 )   27764 - 27771   2023.9   eISSN:2046-2069

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    γ-Carbonyl-substituted ε-caprolactones were found to predominantly isomerize to five-membered lactones rather than to form desired linear polyesters in ring-opening polymerization.

    DOI: 10.1039/d3ra01025b

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  • The Intermediate Water Concept for Pioneering Polymeric Biomaterials: A Review and Update

    Shin-nosuke Nishimura, Masaru Tanaka

    Bulletin of the Chemical Society of Japan   96 ( 9 )   1052 - 1070   2023.9   ISSN:0009-2673 eISSN:1348-0634

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  • Cellular characterization of hiPS CMs cultured on PMEA analogous polymers with different bound water content Reviewed

    KURITA Hiroko, KOBAYASHI Shingo, ANADA Takahisa, TANAKA Masaru, TODO Mitsugu

    Engineering sciences reports, Kyushu University   45 ( 1 )   1 - 6   2023.9   ISSN:13467883

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    In recent years, human iPS cell-derived cardiomyocytes (hiPS-CMs) have attracted much attention in the arena of regenerative therapies. However, hiPS-CMs are known to be immature and have lower contractility than the adult heart. In this study, we investigated the effect of material properties of scaffold surfaces on hiPS-CMs with the aim of improving the contractility of hiPS-CMs. PMEA analogs with varying surface-bound water content, which affect cell adhesion/proliferation behavior, were selected as scaffold materials to coat PET substrates. The cell characteristics of the hiPS-CMs seeded on the scaffolds were evaluated. The initial cell adhesion area tended to be smaller on substrates with a higher amount of bound water. With further incubation, the hiPS-CMs formed self-pulsating aggregates on the substrate. On the substrates with high bound water content, the area of the hiPS-CMs aggregates tended to be smaller while the pulsation behavior became greater. The results indicate that PMEA analogues might affect the cellular properties of hiPS-CMs.

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  • Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review

    Kumar, A; Sood, A; Agrawal, G; Thakur, S; Thakur, VK; Tanaka, M; Mishra, YK; Christie, G; Mostafavi, E; Boukherroub, R; Hutmacher, DW; Han, SS

    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   247   125606   2023.8   ISSN:0141-8130 eISSN:1879-0003

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    Nature-derived or biologically encouraged hydrogels have attracted considerable interest in numerous biomedical applications owing to their multidimensional utility and effectiveness. The internal architecture of a hydrogel network, the chemistry of the raw materials involved, interaction across the interface of counter ions, and the ability to mimic the extracellular matrix (ECM) govern the clinical efficacy of the designed hydrogels. This review focuses on the mechanistic viewpoint of different biologically driven/inspired biomacromolecules that encourages the architectural development of hydrogel networks. In addition, the advantage of hydrogels by mimicking the ECM and the significance of the raw material selection as an indicator of bioinertness is deeply elaborated in the review. Furthermore, the article reviews and describes the application of polysaccharides, proteins, and synthetic polymer-based multimodal hydrogels inspired by or derived from nature in different biomedical areas. The review discusses the challenges and opportunities in biomaterials along with future prospects in terms of their applications in biodevices or functional components for human health issues. This review provides information on the strategy and inspiration from nature that can be used to develop a link between multimodal hydrogels as the main frame and its utility in biomedical applications as the primary target.

    DOI: 10.1016/j.ijbiomac.2023.125606

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  • New techniques for jet calibration with the ATLAS detector

    Aad, G; Abbott, B; Abbott, DC; Abud, AA; Abeling, K; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Achkar, B; Adachi, S; Adam, L; Bourdarios, CA; Adamczyk, L; Adamek, L; Adelman, J; Adersberger, M; Adiguzel, A; Adorni, S; Adye, T; Affolder, AA; Afik, Y; Agapopoulou, C; Agaras, MN; Aggarwal, A; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Ahmed, WS; Ai, X; Aielli, G; Akatsuka, S; Åkesson, TPA; Akilli, E; Akimov, A; Al Khoury, K; Alberghi, GL; Albert, J; Verzini, MJA; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexopoulos, T; Alfonsi, A; Alfonsi, F; Alhroob, M; Ali, B; Aliev, M; Alimonti, G; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, F; Alpigiani, C; Alshehri, AA; Camelia, EA; Estevez, MA; Alviggi, MG; Coutinho, YA; Ambler, A; Ambroz, L; Amelung, C; Amidei, D; Dos Santos, SPA; Amoroso, S; Amrouche, CS; An, F; Anastopoulos, C; Andari, N; Andeen, T; Anders, CF; Anders, JK; Andreazza, A; Andrei, ; Anelli, CR; Angelidakis, S; Angerami, A; Anisenkov, A; Annovi, A; Antel, C; Anthony, MT; Antipov, E; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Pozo, JAA; Bella, LA; Araque, JP; Ferraz, VA; Pereira, RA; Arcangeletti, C; Arce, ATH; Arduh, FA; Arguin, JF; Argyropoulos, S; Arling, JH; Armbruster, AJ; Armstrong, A; Arnaez, O; Arnold, H; Tame, ZPA; Artoni, G; Artz, S; Asai, S; Asawatavonvanich, T; Asbah, N; Asimakopoulou, EM; Asquith, L; Assahsah, J; Assamagan, K; Astalos, R; Atkin, RJ; Atkinson, M; Atlay, NB; Atmani, H; Augsten, K; Avolio, G; Ayoub, MK; Azuelos, G; Bachacou, H; Bachas, K; Backes, M; Backman, F; Bagnaia, P; Bahmani, M; Bahrasemani, H; Bailey, AJ; Bailey, VR; Baines, JT; Bakalis, C; Baker, OK; Bakker, PJ; Gupta, DB; Balaji, S; Baldin, EM; Balek, P; Balli, F; Balunas, WK; Balz, J; Banas, E; Bandyopadhyay, A; Banerjee, S; Bannoura, AAE; Barak, L; Barbe, WM; Barberio, EL; Barberis, D; Barbero, M; Barbour, G; Barillari, T; Barisits, MS; Barkeloo, J; Barklow, T; Barnea, R; Barnett, BM; Barnett, RM; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, AJ; Navarro, LB; Barreiro, F; da Costa, JBG; Barsov, S; Bartoldus, R; Bartolini, G; Barton, AE; Bartos, P; Basalaev, A; Basan, A; Bassalat, A; Basso, MJ; Bates, RL; Batlamous, S; Batley, JR; Batool, B; Battaglia, M; Bauce, M; Bauer, F; Bauer, KT; Bawa, HS; Beacham, JB; Beau, T; Beauchemin, PH; Becherer, F; Bechtle, P; Beck, HC; Beck, HP; Becker, K; Becot, C; Beddall, A; Beddall, AJ; Bednyakov, VA; Bedognetti, M; Beermann, TA; Begalli, M; Begel, M; Behera, A; Behr, JK; Beisiegel, F; Bell, AS; Bella, G; Bellagamba, L; Bellerive, A; Bellos, P; Beloborodov, K; Belotskiy, K; Belyaev, NL; Benchekroun, D; Benekos, N; Benhammou, Y; Benjamin, DP; Benoit, M; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Bergmann, B; Bergsten, LJ; Beringer, J; Berlendis, S; Bernardi, G; Bernius, C; Bernlochner, FU; Berry, T; Berta, P; Bertella, C; Bertram, IA; Bylund, OB; Besson, N; Bethani, A; Bethke, S; Betti, A; Bevan, AJ; Beyer, J; Bhattacharya, DS; Bhattarai, P; Bi, R; Bianchi, RM; Biebel, O; Biedermann, D; Bielski, R; Bierwagen, K; Biesuz, N; Biglietti, M; Billoud, TRV; Bindi, M; Bingul, A; Bini, C; Biondi, S; Birman, M; Bisanz, T; Biswal, JP; Biswas, D; Bitadze, A; Bittrich, C; Bjorke, K; Blazek, T; Bloch, ; Blocker, C; Blue, A; Blumenschein, U; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, ; Bokan, P; Bold, T; Bolz, AE; Bomben, M; Bona, M; Bonilla, JS; Boonekamp, M; Booth, CD; Borecka-Bielska, HM; Borgna, LS; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Boscherini, D; Bosman, M; Sola, JDB; Bouaouda, K; Boudreau, J; Bouhova-Thacker, E; Boumediene, D; Boutle, SK; Boveia, A; Boyd, J; Boye, D; Boyko, IR; Bozson, AJ; Bracinik, J; Brahimi, N; Brandt, G; Brandt, O; Braren, F; Brau, B; Brau, JE; Madden, WDB; Brendlinger, K; Brenner, L; Brenner, R; Bressler, S; Brickwedde, B; Briglin, DL; Britton, D; Britzger, D; Brock, ; Brock, R; Brooijmans, G; Brooks, WK; Brost, E; Broughton, JH; de Renstrom, PAB; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Bruno, S; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Bugge, MK; Bührer, F; Bulekov, O; Burch, TJ; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burr, JTP; Burton, CD; Burzynski, JC; Büscher, ; Buschmann, E; Bussey, PJ; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Vazquez, CJB; Buzatu, A; Buzykaev, AR; Cabras, G; Urbán, SC; Caforio, D; Cai, H; Cairo, VMM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; Caltabiano, A; Lopez, SC; Calvet, D; Calvet, S; Calvet, TP; Calvetti, M; Toro, RC; Camarda, S; Munoz, DC; Camarri, P; Cameron, D; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, ; Canesse, A; Bret, MC; Cantero, J; Cao, T; Cao, Y; Garrido, MDMC; Capua, M; Cardarelli, R; Cardillo, F; Carducci, G; Carli, ; Carli, T; Carlino, G; Carlson, BT; Carminati, L; Carney, RMD; Caron, S; Carquin, E; Carrá, S; Carter, JWS; Casado, MP; Casha, AF; Casper, DW; Castelijn, R; Castillo, FL; Garcia, LC; Gimenez, VC; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Cavaliere, ; Cavallaro, E; Cavalli-Sforza, M; Cavasinni, ; Celebi, E; Alberich, LC; Cerny, K; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chadi, Z; Chakraborty, D; Chan, J; Chan, WS; Chan, WY; Chapman, JD; Chargeishvili, B; Charlton, DG; Charman, TP; Chau, CC; Che, S; Chekanov, S; Chekulaev, S; Chelkov, GA; Chen, B; Chen, C; Chen, CH; Chen, H; Chen, J; Chen, S; Chen, SJ; Chen, X; Chen, YH; Cheng, HC; Cheng, HJ; Cheplakov, A; Cheremushkina, E; El Moursli, RC; Cheu, E; Cheung, K; Chevalerias, TJA; Chevalier, L; Chiarella, ; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, ; Chiu, YH; Chizhov, M; Choi, K; Chomont, AR; Chouridou, S; Chow, YS; Chu, MC; Chu, X; Chudoba, J; Chwastowski, JJ; Chytka, L; Cieri, D; Ciesla, KM; Cinca, D; Cindro, ; Cioara, IA; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Ciubotaru, DA; Ciungu, BM; Clark, A; Clark, MR; Clark, PJ; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; De Sa, RCL; Cohen, H; Coimbra, AEC; Cole, B; Colijn, AP; Collot, J; Muiño, PC; Connell, SH; Connelly, IA; Constantinescu, S; Conventi, F; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Corpe, LD; Corradi, M; Corrigan, EE; Corriveau, F; Costa, MJ; Costanza, F; Costanzo, D; Cowan, G; Cowley, JW; Crane, J; Cranmer, K; Crawley, SJ; Creager, RA; Crepe-Renaudin, S; Crescioli, F; Cristinziani, M; Croft, ; Crosetti, G; Cueto, A; Donszelmann, TC; Cukierman, AR; Cunningham, WR; Czekierda, S; Czodrowski, P; De Sousa, MJDS; Pinto, JVD; Da Via, C; Dabrowski, W; Dachs, F; Dado, T; Dahbi, S; Dai, T; Dallapiccola, C; Dam, M; D'amen, G; D'Amico, ; Damp, J; Dandoy, JR; Daneri, MF; Dann, NS; Danninger, M; Dao, ; Darbo, G; Dartsi, O; Dattagupta, A; Daubney, T; D'Auria, S; David, C; Davidek, T; Davis, DR; Dawson, ; Day-hall, HA; De, K; De Asmundis, R; De Beurs, M; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santis, M; De Santo, A; Corga, KD; De Regie, JBD; Debenedetti, C; Dedovich, D; Deiana, AM; Del Peso, J; Diaz, YD; Delgove, D; Deliot, F; Delitzsch, CM; Della Pietra, M; Della Volpe, D; Dell'Acqua, A; Dell'Asta, L; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Demontigny, G; Denisov, SP; D'Eramo, L; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Deutsch, C; Devesa, MR; Deviveiros, PO; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Gregorio, G; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Sipio, R; Diaconu, C; Dias, FA; Do Vale, TD; Diaz, MA; Dickinson, J; Diehl, EB; Dietrich, J; Cornell, SD; Dimitrievska, A; Ding, W; Dingfelder, J; Dittus, F; Djama, F; Djobava, T; Djuvsland, J; Vale, MAB; 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    EUROPEAN PHYSICAL JOURNAL C   83 ( 8 )   2023.8   ISSN:1434-6044 eISSN:1434-6052

  • Microphase separation of double-hydrophilic poly(carboxybetaine acrylate)-poly(2-methoxyethyl acrylate) block copolymers in water

    Yuji Higaki, Honoka Toyama, Takumi Masuda, Shingo Kobayashi, Masaru Tanaka

    Polymer Journal   55 ( 12 )   1357 - 1365   2023.8   ISSN:0032-3896 eISSN:1349-0540

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    DOI: 10.1038/s41428-023-00831-3

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  • Stealth and pseudo-stealth nanocarriers Reviewed International coauthorship

    Wen, P., Ke, W., Dirisala, A., Toh, K., Tanaka, M., Li, J.

    Advanced Drug Delivery Reviews   198   114895 - 114895   2023.7   ISSN:0169-409X eISSN:1872-8294

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    DOI: 10.1016/j.addr.2023.114895

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  • Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes

    Shingo Kobayashi, Masaru Tanaka

    Molecular Systems Design & Engineering   8 ( 8 )   960 - 991   2023.6   ISSN:2058-9689

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    DOI: 10.1039/D3ME00063J

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  • Effect of titanium-doped bioactive glass on poly(2-hydroxyethyl methacrylate) hydrogel composites: Bioactivity, intermediate water, cell proliferation, and adhesion force

    Mostafa Mabrouk, Hanan H. Beherei, Shohei Shiomoto, Yukiko Tanaka, Lamyaa Osama, Masaru Tanaka

    Ceramics International   49 ( 9 )   13469 - 13481   2023.5   ISSN:0272-8842 eISSN:1873-3956

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    DOI: 10.1016/j.ceramint.2022.12.221

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  • Characterization of polypropyleneimine as an alternative transfection reagent Reviewed

    Riku Saeki, Shingo Kobayashi, Rena Shimazui, Teruki Nii, Akihiro Kishimura, Takeshi Mori, Masaru Tanaka, Yoshiki Katayama

    Analytical Sciences   39 ( 6 )   1015 - 1020   2023.3   ISSN:0910-6340 eISSN:1348-2246

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    DOI: 10.1007/s44211-023-00284-x

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    Other Link: https://link.springer.com/article/10.1007/s44211-023-00284-x/fulltext.html

  • Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates. International journal

    Masatoshi Nomura, Yuhki Yokoyama, Daishi Yoshimura, Yasuhisa Minagawa, Aki Yamamoto, Yukiko Tanaka, Naoko Sekiguchi, Daiki Marukawa, Momoko Ichihara, Hiroaki Itakura, Kenichi Matsumoto, Yoshihiro Morimoto, Hideo Tomihara, Akira Inoue, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Hidenori Takahashi, Mamoru Uemura, Shogo Kobayashi, Tsunekazu Mizushima, Takahisa Anada, Masaki Mori, Yuichiro Doki, Masaru Tanaka, Hidetoshi Eguchi, Hirofumi Yamamoto

    International journal of molecular sciences   24 ( 4 )   2023.2   ISSN:1661-6596 eISSN:1422-0067

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    Here we aimed to establish a simple detection method for detecting circulating tumor cells (CTCs) in the blood sample of colorectal cancer (CRC) patients using poly(2-methoxyethyl acrylate) (PMEA)-coated plates. Adhesion test and spike test using CRC cell lines assured efficacy of PMEA coating. A total of 41 patients with pathological stage II-IV CRC were enrolled between January 2018 and September 2022. Blood samples were concentrated by centrifugation by the OncoQuick tube, and then incubated overnight on PMEA-coated chamber slides. The next day, cell culture and immunocytochemistry with anti-EpCAM antibody were performed. Adhesion tests revealed good attachment of CRCs to PMEA-coated plates. Spike tests indicated that ~75% of CRCs from a 10-mL blood sample were recovered on the slides. By cytological examination, CTCs were identified in 18/41 CRC cases (43.9%). In cell cultures, spheroid-like structures or tumor-cell clusters were found in 18/33 tested cases (54.5%). Overall, CTCs and/or growing circulating tumor cells were found in 23/41 CRC cases (56.0%). History of chemotherapy or radiation was significantly negatively correlated with CTC detection (p = 0.02). In summary, we successfully captured CTCs from CRC patients using the unique biomaterial PMEA. Cultured tumor cells will provide important and timely information regarding the molecular basis of CTCs.

    DOI: 10.3390/ijms24043949

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  • Comparative study of PEG and PEGylated dendrimers in their eutectic mixtures with water analyzed using X-ray diffraction and infrared spectroscopy

    Kojima, C., Suzuki, Y., Ikemoto, Y., Tanaka, M., Matsumoto, A.

    Polymer Journal   55 ( 1 )   63 - 73   2023.1   ISSN:0032-3896 eISSN:1349-0540

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    DOI: 10.1038/s41428-022-00700-5

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  • https://www.soft-material.jp/achievement/articles Invited Reviewed

    2023.1

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  • Behavior of supramolecular cross-links formed by host-guest interactions in hydrogels responding to water contents

    Chiharu Ueda, Junsu Park, Kazuya Hirose, Subaru Konishi, Yuka Ikemoto, Motofumi Osaki, Hiroyasu Yamaguchi, Akira Harada, Masaru Tanaka, Go Watanabe, Yoshinori Takashima

    Supramolecular Materials   1   100001 - 100001   2022.12   ISSN:2667-2405

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    DOI: 10.1016/j.supmat.2021.100001

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  • Honeycomb-like Structured Film, a Novel Therapeutic Device, Suppresses Tumor Growth in an In Vivo Ovarian Cancer Model

    Tsuyoshi Ohta, Masaru Tanaka, Seitaro Taki, Hiroyuki Nakagawa, Satoru Nagase

    Cancers   2022.12

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  • Honeycomb-like Structured Film, a Novel Therapeutic Device, Suppresses Tumor Growth in an In Vivo Ovarian Cancer Model

    Tsuyoshi Ohta, Masaru Tanaka, Seitaro Taki, Hiroyuki Nakagawa, Satoru Nagase

    Cancers   2022.12

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    DOI: 10.3390/cancers15010237

  • Alkyl chain length-dependent protein nonadsorption and adsorption properties of crystalline alkyl β-celluloside assemblies

    Serizawa, T., Yamaguchi, S., Amitani, M., Ishii, S., Tsuyuki, H., Tanaka, Y., Sawada, T., Kawamura, I., Watanabe, G., Tanaka, M.

    Colloids and Surfaces B: Biointerfaces   220   112898   2022.12   ISSN:0927-7765 eISSN:1873-4367

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  • Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet-Resistant Bioelectrode Applications

    Huang, J.-J., Lin, C.-H., Tanaka, Y., Yamamoto, A., Luo, S.-C., Tanaka, M.

    Advanced Materials Interfaces   9 ( 33 )   2022.11   ISSN:2196-7350

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  • Enrichment of Cancer Cells Based on Antibody-Free Selective Cell Adhesion

    Shingo Kobayashi, Atsushi Sugasaki, Yosuke Yamamoto, Yuta Shigenoi, Airi Udaka, Aki Yamamoto, Masaru Tanaka

    ACS Biomaterials Science & Engineering   8 ( 10 )   4547 - 4556   2022.10   ISSN:2373-9878 eISSN:2373-9878

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  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Park J., Ueda T., Kawai Y., Araki K., Kido M., Kure B., Takenaka N., Takashima Y., Tanaka M.

    RSC Advances   12 ( 43 )   27912 - 27917   2022.9

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    The demand for artificial blood vessels to treat vascular disease will continue to increase in the future. To expand the application of blood-compatible poly(2-methoxyethyl acrylate) (pMEA) to artificial blood vessels, control of the mechanical properties of pMEA is established using supramolecular cross-links based on inclusion complexation of acetylated cyclodextrin. The mechanical properties, such as Young's modulus and toughness, of these pMEA-based elastomers change with the amount of cross-links, maintaining tissue-like behavior (J-shaped stress-strain curve). Regardless of the cross-links, the pMEA-based elastomers exhibit low platelet adhesion properties (approximately 3% platelet adherence) compared with those of poly(ethylene terephthalate), which is one of the commercialized materials for artificial blood vessels. Contact angle measurements imply a shift of supramolecular cross-links in response to the surrounding environment. When immersed in water, hydrophobic supramolecular cross-links are buried within the interior of the materials, thereby exposing pMEA chains to the aqueous environment; this is why supramolecular cross-links do not affect the platelet adhesion properties. In addition, the elastomers exhibit stable adhesion to human umbilical vein endothelial cells. This report shows the potential of combining supramolecular cross-links and pMEA.

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  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Park, J; Ueda, T; Kawai, Y; Araki, K; Kido, M; Kure, B; Takenaka, N; Takashima, Y; Tanaka, M

    RSC ADVANCES   12 ( 43 )   27912 - 27917   2022.9   eISSN:2046-2069

  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate.

    Park J, Ueda T, Kawai Y, Araki K, Kido M, Kure B, Takenaka N, Takashima Y, Tanaka M

    RSC advances   12 ( 43 )   27912 - 27917   2022.9

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  • Organic carboxylate salt-enabled alternative synthetic routes for bio-functional cyclic carbonates and aliphatic polycarbonates

    Yuya Watanabe, Shunya Takaoka, Yuta Haga, Kohei Kishi, Shunta Hakozaki, Atsushi Narumi, Takashi Kato, Masaru Tanaka, Kazuki Fukushima

    Polymer Chemistry   13 ( 36 )   5193 - 5199   2022.9   ISSN:1759-9954 eISSN:1759-9962

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    A cyclic carbonate with an ammonium carboxylate residue was found to serve as a nucleophile for esterification with alkyl bromides via the S<sub>N</sub>2 mechanism.

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  • ソフトバイオマテリアル・バイオ界面における水の状態と役割

    田中 賢

    化学と教育   70 ( 7 )   348 - 351   2022.7   ISSN:03862151 eISSN:24241830

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    <p>医療製品の開発には,生体に接触する環境で安全に機能する生体親和性に優れたソフトバイオマテリアルが必須である。医療製品は,使用する前の滅菌済みの乾燥状態から,使用時にはウエットな状態に変化する。本講座では,製品使用環境で存在する水の視点を考慮し,材料と生体の接触点であるバイオ界面の設計における課題と進展について概説する。生体親和性に強く影響する材料—細胞間相互作用には,多くの因子が関与している。我々は,生体親和性合成材料と生体分子に形成される水の状態を調べ,特定の構造と運動性を有する中間水が共通点であることを明らかにした。中間水のバイオ界面における役割について考察する。</p>

    DOI: 10.20665/kakyoshi.70.7_348

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  • Roles of interfacial water states on advanced biomedical material design

    Kei Nishida, Takahisa Anada, Masaru Tanaka

    Advanced Drug Delivery Reviews   186   114310   2022.7   ISSN:0169-409X eISSN:1872-8294

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    When biomedical materials come into contact with body fluids, the first reaction that occurs on the material surface is hydration; proteins are then adsorbed and denatured on the hydrated material surface. The amount and degree of denaturation of adsorbed proteins affect subsequent cell behavior, including cell adhesion, migration, proliferation, and differentiation. Biomolecules are important for understanding the interactions and biological reactions of biomedical materials to elucidate the role of hydration in biomedical materials and their interaction partners. Analysis of the water states of hydrated materials is complicated and remains controversial; however, knowledge about interfacial water is useful for the design and development of advanced biomaterials. Herein, we summarize recent findings on the hydration of synthetic polymers, supramolecular materials, inorganic materials, proteins, and lipid membranes. Furthermore, we present recent advances in our understanding of the classification of interfacial water and advanced polymer biomaterials, based on the intermediate water concept.

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  • Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-methoxyethyl acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel Reviewed

    Md Azizul Haque, Daiki Murakami, Masaru Tanaka

    Surfaces   5 ( 3 )   365 - 382   2022.7   eISSN:2571-9637

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    Poly(2-methoxyethyl acrylate) (PMEA) is a US FDA-approved biocompatible polymer, although there is insufficient work on human umbilical vein endothelial cells (HUVECs) and platelet interaction analysis on PMEA-analogous polymers. In this study, we extensively investigated HUVEC–polymer and platelet–polymer interaction behavior by measuring the adhesion strength using single-cell force spectroscopy. Furthermore, the hydration layer of the polymer interface was observed using frequency-modulation atomic force microscopy. We found that endothelial cells can attach and spread on the PMEA surface with strong adhesion strength compared to other analogous polymers. We found that the hydration layers on the PMEA-analogous polymers were closely related to their weak platelet adhesion behavior. Based on our results, it can be concluded that PMEA is a promising candidate for the construction of artificial small-diameter blood vessels owing to the presence of IW and a hydration layer on the interface.

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  • Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode

    Mabrouk, M., Beherei, H.H., Tanaka, Y., Tanaka, M.

    Biomaterials Advances   138   212965   2022.7   ISSN:2772-9508 eISSN:2772-9508

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  • Infrared Spectra and Hydrogen-Bond Configurations of Water Molecules at the Interface of Water-Insoluble Polymers under Humidified Conditions International journal

    Yuka Ikemoto, Yoshihisa Harada, Masaru Tanaka, Shin-nosuke Nishimura, Daiki Murakami, Naoya Kurahashi, Taro Moriwaki, Kosuke Yamazoe, Hitoshi Washizu, Yoshiki Ishii, Hajime Torii

    The Journal of Physical Chemistry B   2022.6

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    DOI: 10.1021/acs.jpcb.2c01702

  • Characterization of Hydration Water Bound to Choline Phosphate-Containing Polymers

    Shohei Shiomoto, Kaito Inoue, Hayato Higuchi, Shin-nosuke Nishimura, Hiromitsu Takaba, Masaru Tanaka, Motoyasu Kobayashi

    Biomacromolecules   23 ( 7 )   2999 - 3008   2022.6   ISSN:1525-7797 eISSN:1526-4602

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  • Poly(2-Methoxyethyl Acrylate) (PMEA)-Coated Anti-Platelet Adhesive Surfaces to Mimic Native Blood Vessels through HUVECs Attachment, Migration, and Monolayer Formation Reviewed

    Md Azizul Haque, Daiki Murakami, Takahisa Anada, Masaru Tanaka

    Coatings   12 ( 6 )   869   2022.6   eISSN:2079-6412

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    Confluent monolayers of human umbilical vein endothelial cells (HUVECs) on a poly(2-methoxyethyl acrylate) (PMEA) antithrombogenic surface play a major role in mimicking the inner surface of native blood vessels. In this study, we extensively investigated the behavior of cell–polymer and cell–cell interactions by measuring adhesion strength using single-cell force spectroscopy. In addition, the attachment and migration of HUVECs on PMEA-analogous substrates were detected, and the migration rate was estimated. Moreover, the bilateral migration of HUVECs between two adjacent surfaces was observed. Furthermore, the outer surface of HUVEC was exam-ined using frequency-modulation atomic force microscopy (FM-AFM). Hydration was found to be an indication of a healthy glycocalyx layer. The results were compared with the hydration states of individual PMEA-analogous polymers to understand the adhesion mechanism between the cells and substrates in the interface region. HUVECs could attach and spread on the PMEA surface with stronger adhesion strength than self-adhesion strength, and migration occurred over the surface of analogue polymers. We confirmed that platelets could not adhere to HUVEC monolayers cultured on the PMEA surface. FM-AFM images revealed a hydration layer on the HUVEC surfaces, indicating the presence of components of the glycocalyx layer in the presence of intermediate water. Our findings show that PMEA can mimic original blood vessels through an antithrombogenic HUVEC monolayer and is thus suitable for the construction of artificial small-diameter blood vessels.

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  • Biocompatible poly(N-(ω-acryloyloxy-n-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly(N-isopropylacrylamide)

    Shin-nosuke Nishimura, Kei Nishida, Tomoya Ueda, Shohei Shiomoto, Masaru Tanaka

    Polymer Chemistry   13 ( 17 )   2519 - 2530   2022.5   ISSN:1759-9954 eISSN:1759-9962

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    The biocompatible (co)polymers undergoes a thermal stimulus-driven liquid–liquid phase separation and form coacervates above the lower critical solution temperature (LCST). The LCSTs are able to be precisely controlled between 0 °C and 100 °C.

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  • Surfactant-free suspension polymerization of hydrophilic monomers with an oil-in-water system for the preparation of microparticles toward the selective isolation of tumor cells Reviewed

    Shin-nosuke Nishimura, Kei Nishida, Shohei Shiomoto, Masaru Tanaka

    Materials Advances   3 ( 12 )   5043 - 5054   2022.5   eISSN:2633-5409

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    Polymer microparticles, composed of water-soluble hydrophilic monomers, are synthesized via surfactant-free suspension polymerization with an oil-in-water system. Microparticles formed from PMEA have potential as a platform to capture tumor cells.

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  • Effect of Osmolytes on Water Mobility Correlates with Their Stabilizing Effect on Proteins International journal

    Mafumi Hishida, Rubaiya Anjum, Takahisa Anada, Daiki Murakami, Masaru Tanaka

    The Journal of Physical Chemistry B   126 ( 13 )   2466 - 2475   2022.4   ISSN:1520-6106 eISSN:1520-5207

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    There is a long, ongoing debate on how small molecules (osmolytes) affect the stability of proteins. The present study found that change in collective rotational dynamics of water in osmolyte solutions likely has a dominant effect on protein denaturation. According to THz spectroscopy analysis, osmolytes that stabilize proteins are accompanied by bound hydration water with slow dynamics, while the collective rotational dynamics of water is accelerated in the case of denaturant osmolytes. Among 15 osmolytes studied here, there is a good correlation between the change in mobility in terms of water rotational dynamics and the denaturation temperature of ribonuclease A. The changes in water dynamics due to osmolytes can be regarded as a pseudo-temperature-change, which agrees well with the change in protein denaturation temperature. These results indicate that the molecular dynamics of water around the protein is a key factor for protein denaturation.

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  • Nanoscopic analyses of cell-adhesive protein adsorption on poly(2-methoxyethyl acrylate) surfaces Reviewed

    Nishida, K., Baba, K., Murakami, D., Tanaka, M.

    Biomaterials Science   10 ( 11 )   2953 - 2963   2022.4   ISSN:2047-4830 eISSN:2047-4849

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  • Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer

    Kei Nishida, Shin-nosuke Nishimura, Masaru Tanaka

    Biomacromolecules   23 ( 4 )   1569 - 1580   2022.4   ISSN:1525-7797 eISSN:1526-4602

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  • Experimental Evidence of Slow Mode Water in the Vicinity of Poly(ethylene oxide) at Physiological Temperature. International journal

    Taiki Tominaga, Mafumi Hishida, Daiki Murakami, Yoshihisa Fujii, Masaru Tanaka, Hideki Seto

    The journal of physical chemistry. B   126 ( 8 )   1758 - 1767   2022.3   ISSN:1520-6106 eISSN:1520-5207

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    In some synthetic polymers used for medical applications, hydration water in the vicinity of the polymer chains is known to play an important role in biocompatibility and is referred to as intermediate water. The crystallization of water below 0 °C observed during thermal analysis has been considered as evidence of the presence of intermediate water. However, the origin and physicochemical properties of intermediate water have not yet been elucidated. In this study, as a typical biocompatible polymer, poly(ethylene oxide) and its hydration water were investigated with the use of terahertz time-domain spectroscopy and quasi-elastic neutron scattering. The obtained results prove the existence of a significant amount of mobile water that interacts with the polymer chains even when the water content is low at physiological temperatures.

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  • Modulation of Biological Responses of Tumor Cells Adhered to Poly(2-methoxyethyl acrylate) with Increasing Cell Viability under Serum-Free Conditions

    Kei Nishida, Shogo Sekida, Takahisa Anada, Masaru Tanaka

    ACS Biomaterials Science & Engineering   8 ( 2 )   672 - 681   2022.2   ISSN:2373-9878 eISSN:2373-9878

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  • Observing the repulsion layers on blood-compatible polymer-grafted interfaces by frequency modulation atomic force microscopy

    Daiki Murakami, Shin-nosuke Nishimura, Yukiko Tanaka, Masaru Tanaka

    Biomaterials Advances   133   112596 - 112596   2022.2   ISSN:2772-9508 eISSN:2772-9508

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  • A β-hairpin peptide with pH-controlled affinity for tumor cells

    Shin-nosuke Nishimura, Kei Nishida, Masaru Tanaka

    Chemical Communications   58 ( 4 )   505 - 508   2022.1   ISSN:1359-7345 eISSN:1364-548X

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    This peptide undergoes a pH-driven conformational switch between a random coil structure with a flexible linear RGD epitope and a β-hairpin structure with a rigid RGD loop. The β-hairpin-structured peptide is more readily internalized by tumor cells.

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  • Fluorine-containing bio-inert polymers: Roles of intermediate water

    Koguchi, R., Jankova, K., Tanaka, M.

    Acta Biomaterialia   138   34 - 56   2022.1   ISSN:1742-7061 eISSN:1878-7568

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  • Anisotropic, Degradable Polymer Assemblies Driven by a Rigid Hydrogen-Bonding Motif That Induce Shape-Specific Cell Responses

    Kazuki Fukushima, Kodai Matsuzaki, Masashi Oji, Yuji Higuchi, Go Watanabe, Yuki Suzuki, Moriya Kikuchi, Nozomi Fujimura, Naofumi Shimokawa, Hiroaki Ito, Takashi Kato, Seigou Kawaguchi, Masaru Tanaka

    Macromolecules   55 ( 1 )   15 - 25   2022.1   ISSN:0024-9297 eISSN:1520-5835

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    DOI: 10.1021/acs.macromol.1c01894

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  • Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation

    Daiki Murakami, Kosuke Yamazoe, Shin-nosuke Nishimura, Naoya Kurahashi, Tomoya Ueda, Jun Miyawaki, Yuka Ikemoto, Masaru Tanaka, Yoshihisa Harada

    Langmuir   38 ( 3 )   1090 - 1098   2022.1   ISSN:0743-7463 eISSN:1520-5827

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    DOI: 10.1021/acs.langmuir.1c02672

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  • Water modulates the lamellar structure and interlayer correlation of poly(perfluorooctyl acrylate) films: a specular and off-specular neutron scattering study

    Yamamoto, A; Higaki, Y; Thoma, J; Kimmle, E; Ishige, R; Demé, B; Takahara, A; Tanaka, M

    POLYMER JOURNAL   54 ( 1 )   57 - 65   2022.1   ISSN:0032-3896 eISSN:1349-0540

  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Park, J., Ueda, T., Kawai, Y., Araki, K., Kido, M., Kure, B., Takenaka, N., Takashima, Y., Tanaka, M.

    RSC Advances   12 ( 43 )   2022   ISSN:2046-2069

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  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Junsu Park, Tomoya Ueda, Yusaku Kawai, Kumiko Araki, Makiko Kido, Bunsho Kure, Naomi Takenaka, Yoshinori Takashima, Masaru Tanaka

    RSC Advances   2022

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  • Effect of pendant groups on the blood compatibility and hydration states of poly(2-oxazoline)s

    Liu, S., Kobayashi, S., Nishimura, S.-N., Ueda, T., Tanaka, M.

    Journal of Polymer Science   59 ( 21 )   2559 - 2570   2021.11

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    DOI: 10.1002/pol.20210410

  • Effect of amount of hydrated water and mobility of hydrated poly(2‐methoxyethyl acrylate) on denaturation of adsorbed fibrinogen

    59 ( 22 )   2763 - 2770   2021.11

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    DOI: 10.1002/pol.20210496

  • Conformable microneedle pH sensors via the integration of two different siloxane polymers for mapping peripheral artery disease

    Wonryung Lee, Seung-hwan Jeong, Young-Woo Lim, Hyunhwan Lee, Joohyuk Kang, Hyunjae Lee, Injun Lee, Hyung-Seop Han, Shingo Kobayashi, Masaru Tanaka, Byeong-Soo Bae

    Science Advances   7 ( 48 )   2021.11

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    DOI: 10.1126/sciadv.abi6290

  • Protein- and Cell-Resistance of Zwitterionic Peptide-Based Self-Assembled Monolayers: Anti-Biofouling Tests and Surface Force Analysis

    Ryongsok Chang, Evan Angelo Quimada Mondarte, Debabrata Palai, Taito Sekine, Aki Kashiwazaki, Daiki Murakami, Masaru Tanaka, Tomohiro Hayashi

    Frontiers in Chemistry   9   2021.10

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    DOI: 10.3389/fchem.2021.748017

  • Local Dynamics of the Hydration Water and Poly(Methyl Methacrylate) Chains in PMMA Networks Reviewed International journal

    Yoshihisa Fujii, Taiki Tominaga, Daiki Murakami, Masaru Tanaka, Hideki Seto

    Frontiers in Chemistry   9   728738 - 728738   2021.10

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    DOI: 10.3389/fchem.2021.728738

  • Mechanical Properties with Respect to Water Content of Host–Guest Hydrogels

    54 ( 17 )   8067 - 8076   2021.9

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    DOI: 10.1021/acs.macromol.1c00970

  • Protein Stabilization Effect of Zwitterionic Osmolyte-bearing Polymer

    Rubaiya Anjum, Shin-nosuke Nishimura, Shingo Kobayashi, Kei Nishida, Takahisa Anada, Masaru Tanaka

    Chemistry Letters   50 ( 9 )   1699 - 1702   2021.9

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    DOI: 10.1246/cl.210335

  • Effect of amount of hydrated water and mobility of hydrated poly(2-methoxyethyl acrylate) on denaturation of adsorbed fibrinogen

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    JOURNAL OF POLYMER SCIENCE   2021.8

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    DOI: 10.1002/pol.20210496

  • Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship between Hydration States and Surface Morphology

    Moe Yamazaki, Yosuke Sugimoto, Daiki Murakami, Masaru Tanaka, Tooru Ooya

    Langmuir   37 ( 28 )   8534 - 8543   2021.7

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    DOI: 10.1021/acs.langmuir.1c01003

  • Investigating the intermediate water feature of hydrated titanium containing bioactive glass

    Mabrouk, M., Beherei, H.H., Tanaka, Y., Tanaka, M.

    International Journal of Molecular Sciences   22 ( 15 )   2021.7

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    DOI: 10.3390/ijms22158038

  • Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass

    Mostafa Mabrouk, Hanan H. Beherei, Yukiko Tanaka, Masaru Tanaka

    International Journal of Molecular Sciences   2021.7

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    DOI: 10.3390/ijms22158038

  • First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water

    Kanamaru, T., Araki, M., Takahashi, R., Fujii, S., Shikata, T., Murakami, D., Tanaka, M., Sakurai, K.

    Journal of Physical Chemistry B   125 ( 26 )   7251 - 7261   2021.7

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    DOI: 10.1021/acs.jpcb.1c01864

  • Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship between Hydration States and Surface Morphology

    Moe Yamazaki, Yosuke Sugimoto, Daiki Murakami, Masaru Tanaka, Tooru Ooya

    Langmuir   37 ( 28 )   8534 - 8543   2021.7

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    DOI: 10.1021/acs.langmuir.1c01003

  • First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water

    Takuma Kanamaru, Masataka Araki, Rintaro Takahashi, Shota Fujii, Toshiyuki Shikata, Daiki Murakami, Masaru Tanaka, Kazuo Sakurai

    The Journal of Physical Chemistry B   125 ( 26 )   7251 - 7261   2021.7

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    DOI: 10.1021/acs.jpcb.1c01864

  • Effect of pendant groups on the blood compatibility and hydration states of poly(2‐oxazoline)s

    Shichen Liu, Shingo Kobayashi, Shin‐nosuke Nishimura, Tomoya Ueda, Masaru Tanaka

    59 ( 21 )   2559 - 2570   2021.7

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    DOI: 10.1002/pol.20210410

  • Effect of bound water content on cell adhesion strength to water-insoluble polymers

    Kei Nishida, Takahisa Anada, Shingo Kobayashi, Tomoya Ueda, Masaru Tanaka

    Acta Biomaterialia   134   313 - 324   2021.7

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    DOI: 10.1016/j.actbio.2021.07.058

  • The first observation of the hydration layer around polymer chain by scattering and its relationship to thromboresistance; dilute solution properties of PMEA in THF/water Reviewed International journal

    T. Kanamaru, M. Araki, R. Takahashi, S. Fujii, T. Shikata, D. Murakami, M. Tanaka, K. Sakurai

    The Journal of Physical Chemistry B   2021.6

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  • Poly(tertiary amide acrylate) Copolymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States

    Shichen Liu, Shingo Kobayashi, Toshiki Sonoda, Masaru Tanaka

    Biomacromolecules   22 ( 6 )   2718 - 2728   2021.6

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    DOI: 10.1021/acs.biomac.1c00411

  • Effects of Side-Chain Spacing and Length on Hydration States of Poly(2-methoxyethyl acrylate) Analogues: A Molecular Dynamics Study

    An-Tsung Kuo, Shingo Urata, Ryohei Koguchi, Toshiki Sonoda, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science & Engineering   7 ( 6 )   2383 - 2391   2021.6

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    DOI: 10.1021/acsbiomaterials.1c00388

  • In vitro and In vivo Blood Compatibility of Concentrated Polymer Brushes Invited Reviewed International journal

    C. Yoshikawa, S. Hattori, C-F. Huang, H. Kobayashi, M. Tanaka

    Journal of Materials Chemistry B   2021.6

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  • Poly(tertiary amide acrylate) (Co)polymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States Reviewed International journal

    S. Liu, S. Kobayashi, T. Sonoda, M. Tanaka

    Biomacromolecules   2021.5

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    DOI: 10.1021/acs.biomac.1c0041

  • Attachment and Growth of Fibroblast Cells on Poly(2-methoxyethyl acrylate) Analog Polymers as Coating Materials Reviewed International journal

    6.R. Anjum, K. Nishida, H. Matsumoto, D. Murakami, S. Kobayashi, T. Anada, M. Tanaka

    Coatings   2021.5

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  • Effects of Side-Chain Spacing and Length on Hydration States of the Poly(2-methoxyethyl acrylate) Analogs: A Molecular Dynamics Study Reviewed International journal

    A. T. Kuo, S. Urata, R. Koguchi, T. Sonoda, S. Kobayashi, M. Tanaka

    ACS Biomaterials Science & Engineering   2021.5

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  • Different Hydration States and Passive Tumor Targeting Ability of Polyethylene Glycol-modified Dendrimers with High and Low PEG density Reviewed International journal

    A. Tsujimoto, H. Uehara, H. Yoshida, M. Nishio, K. Furuta, T. Inui, A. Matsumoto, S. Morita, M. Tanaka, C. Kojima

    Materials Science & Engineering C   2021.4

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  • Chain-End Effect for Intermediate Water Formation of Poly(2-Methoxyethyl Acrylate)

    S. Nishimura, T. Ueda, D. Murakami, M. Tanaka

    Organic Materials   03 ( 02 )   214 - 220   2021.4

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    DOI: 10.1055/a-1441-8239

  • Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials

    Rubaiya Anjum, Kei Nishida, Haruka Matsumoto, Daiki Murakami, Shingo Kobayashi, Takahisa Anada, Masaru Tanaka

    Coatings   11 ( 4 )   461 - 461   2021.4

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    DOI: 10.3390/coatings11040461

  • Chain-End Effect for Intermediate Water Formation of Poly(2-Methoxyethyl Acrylate)

    S. Nishimura, T. Ueda, D. Murakami, M. Tanaka

    Organic Materials   03 ( 02 )   214 - 220   2021.4

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    DOI: 10.1055/a-1441-8239

  • Attachment and growth of fibroblast cells on poly (2-methoxyethyl acrylate) analog polymers as coating materials

    Rubaiya Anjum, Kei Nishida, Haruka Matsumoto, Daiki Murakami, Shingo Kobayashi, Takahisa Anada, Masaru Tanaka

    Coatings   11 ( 4 )   2021.4

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    DOI: 10.3390/coatings11040461

  • Chain End Effect for Intermediate Water Formation of Poly(2-methoxyethyl acrylate) Reviewed International journal

    S. Nishimura, T. Ueda, D. Murakami, M. Tanaka

    Organic Materials   2021.4

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  • Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization Reviewed International journal

    T. Sonoda, S. Kobayashi, M. Tanaka

    Macromolecules   2021.3

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  • Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization

    Toshiki Sonoda, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   54 ( 6 )   2862 - 2872   2021.3

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    DOI: 10.1021/acs.macromol.0c02611

  • Effect of interfacial structure based on grafting density of poly(2-methoxyethyl acrylate) on blood compatibility

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   199   2021.3

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    DOI: 10.1016/j.colsurfb.2020.111517

  • Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property Reviewed International journal

    ACS Biomaterials Science & Engineering   2021.2

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  • Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property

    Valentina Montagna, Junko Takahashi, Meng Yu Tsai, Takayuki Ota, Nicolas Zivic, Seigou Kawaguchi, Takashi Kato, Masaru Tanaka, Haritz Sardon, Kazuki Fukushima

    ACS Biomaterials Science and Engineering   7 ( 2 )   472 - 481   2021.2

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    DOI: 10.1021/acsbiomaterials.0c01460

  • Role of Interfacial Water in Determining the Interaction of Proteins and Cells with Hydrated Materials Invited Reviewed International journal

    M. Tanaka, S. Morita, T. Hayashi

    Colloids and Surfaces B: Biointerfaces   2021.2

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  • Effect of Interfacial Structure Based on Grafting Density of Poly(2-Methoxyethyl Acrylate) on Blood Compatibility Reviewed International journal

    T. Ueda, D. Murakami, M. Tanaka

    Colloids and Surfaces B: Biointerfaces   2021.2

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  • A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition Reviewed International journal

    Y. Toyokawa, S. Kobayashi, H. Tsuchiya, T. Shibuya, M. Aoki, J. Sumiya, S. Ooyama, T. Ishizawa, N. Makino, Y. Ueno, M. Tanaka

    Materials Science & Engineering C   2021.2

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  • A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition

    Yoshihide Toyokawa, Shingo Kobayashi, Haruka Tsuchiya, Tomokazu Shibuya, Makiko Aoki, Jun Sumiya, Shun Ooyama, Tetsuya Ishizawa, Naohiko Makino, Yoshiyuki Ueno, Masaru Tanaka

    Materials Science and Engineering: C   120   111386 - 111386   2021.1

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    DOI: 10.1016/j.msec.2020.111386

  • Sulfated Hyaluronan coating of polyurethanebased implant materials Reviewed International journal

    K. Athanasopulu, D. Caltzidou, A. Sekishita, L. Kutuzova, G. Lorenz, M. Tanaka, R. Kemkemer

    Current Directions in Biomedical Engineering   2020.12

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  • Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s

    6 ( 12 )   6690 - 6700   2020.12

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    DOI: 10.1021/acsbiomaterials.0c01220

  • Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s

    6 ( 12 )   6690 - 6700   2020.12

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    DOI: 10.1021/acsbiomaterials.0c01220

  • Side chain spacing control of derivatives of poly(2-methoxyethyl acrylate): impact on hydration states and antithrombogenicity Invited Reviewed International journal

    T. Sonoda, S. Kobayashi, K. Herai, M. Tanaka

    Macromolecules   2020.12

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  • Molecular Dynamics Study on the Water Mobility and Side-chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s Reviewed International journal

    2020.12

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  • Role of interfacial water in determining the interactions of proteins and cells with hydrated materials. International journal

    Masaru Tanaka, Shigeaki Morita, Tomohiro Hayashi

    Colloids and surfaces. B, Biointerfaces   198   111449 - 111449   2020.11

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    DOI: 10.1016/j.colsurfb.2020.111449

  • Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties

    Nishimura, S.-N., Ueda, T., Kobayashi, S., Tanaka, M.

    ACS Applied Polymer Materials   2 ( 11 )   4790 - 4801   2020.11

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    DOI: 10.1021/acsapm.0c00776

  • Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties

    Shin-nosuke Nishimura, Tomoya Ueda, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Polymer Materials   2 ( 11 )   4790 - 4801   2020.11

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    DOI: 10.1021/acsapm.0c00776

  • Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties Reviewed International journal

    S. Nishimura, T. Ueda, S. Kobayashi, M. Tanak

    ACS Applied Polymer Materials   2020.10

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  • Side-Chain Spacing Control of Derivatives of Poly(2-methoxyethyl acrylate): Impact on Hydration States and Antithrombogenicity

    Sonoda, T., Kobayashi, S., Herai, K., Tanaka, M.

    Macromolecules   53 ( 19 )   8570 - 8580   2020.10

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    DOI: 10.1021/acs.macromol.0c01144

  • Side-Chain Spacing Control of Derivatives of Poly(2-methoxyethyl acrylate): Impact on Hydration States and Antithrombogenicity

    Toshiki Sonoda, Shingo Kobayashi, Keisuke Herai, Masaru Tanaka

    Macromolecules   53 ( 19 )   8570 - 8580   2020.10

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    DOI: 10.1021/acs.macromol.0c01144

  • Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement Reviewed International journal

    2020.7

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  • Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement

    6 ( 7 )   3915 - 3924   2020.7

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    DOI: 10.1021/acsbiomaterials.0c00746

  • Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement Reviewed

    6 ( 7 )   3915 - 3924   2020.6

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    DOI: 10.1021/acsbiomaterials.0c00746

  • Understanding the Effect of Hydration on the Bio-inert Properties of 2-Hydroxyethyl Methacrylate Copolymers with Small Amounts of Amino- or/and Fluorine-Containing Monomers

    Koguchi, R., Jankova, K., Hayasaka, Y., Kobayashi, D., Amino, Y., Miyajima, T., Kobayashi, S., Murakami, D., Yamamoto, K., Tanaka, M.

    ACS Biomaterials Science and Engineering   6 ( 5 )   2855 - 2866   2020.5

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    DOI: 10.1021/acsbiomaterials.0c00230

  • Understanding the Effect of Hydration on the Bio-inert Properties of 2-Hydroxyethyl Methacrylate Copolymers with Small Amounts of Amino- or/and Fluorine-Containing Monomers Reviewed

    Ryohei Koguchi, Katja Jankova, Yuki Hayasaka, Daisuke Kobayashi, Yosuke Amino, Tatsuya Miyajima, Shingo Kobayashi, Daiki Murakami, Kyoko Yamamoto, Masaru Tanaka

    ACS Biomaterials Science & Engineering   6 ( 5 )   2855 - 2866   2020.5

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    DOI: 10.1021/acsbiomaterials.0c00230

  • Understanding the effect of hydration on the bio-inert properties of HEMA copolymers with small amounts of amino- or/and fluorine-containing monomers Reviewed International journal

    R. Koguchi, K. Jankova, Y. Hayasaka, D. Kobayashi, Y. Amino, T. Miyajima, S. Kobayashi, D. Murakami, K. Yamamoto, M. Tanaka

    ACS Biomater. Sci. Eng.   2020.5

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  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium Reviewed

    Meng Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020.4

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    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium

    Meng-Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020.4

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    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium Reviewed

    Meng Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020.4

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    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium Reviewed

    Meng-Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020.4

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    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium Reviewed

    Meng Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020.4

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    DOI: 10.1021/acsabm.9b00885

  • Optimal Plasticizer Content for Magnetic Elastomers Used for Cell Culture Substrate Reviewed

    Mayuko Watanabe, Yukiko Tanaka, Daiki Murakami, Masaru Tanaka, Mika Kawai, Tetsu Mitsumata

    CHEMISTRY LETTERS   49 ( 3 )   280 - 283   2020.3

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    DOI: 10.1246/cl.190929

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers Reviewed International journal

    D. Murakami, Y. Segami, T. Ueda, M. Tanaka

    J. Biomater. Sci. Polym. Ed.   2020.2

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  • Optimal plasticizer content for magnetic elastomers used for cell culture substrate Reviewed

    Mayuko Watanabe, Yukiko Tanaka, Daiki Murakami, Masaru Tanaka, Mika Kawai, Tetsu Mitsumata

    Chemistry Letters   49 ( 3 )   280 - 283   2020.1

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    DOI: 10.1246/cl.190929

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers

    Murakami, D., Segami, Y., Ueda, T., Tanaka, M.

    Journal of Biomaterials Science, Polymer Edition   31 ( 2 )   1 - 12   2020.1

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    DOI: 10.1080/09205063.2019.1680930

  • Optimal plasticizer content for magnetic elastomers used for cell culture substrate Reviewed

    Mayuko Watanabe, Yukiko Tanaka, Daiki Murakami, Masaru Tanaka, Mika Kawai, Tetsu Mitsumata

    Chemistry Letters   49 ( 3 )   280 - 283   2020.1

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    DOI: 10.1246/cl.190929

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate) Reviewed

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019.10

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    DOI: 10.1021/acsabm.9b00363

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019.10

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    DOI: 10.1021/acsabm.9b00363

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019.10

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    Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)
    Copyright © 2019 American Chemical Society. The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol &#37; of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a Tg of -35 °C, making H-PMEA a solid rubber-like material with recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement for polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants, and articles with various geometries for the medicinal industry.

    DOI: 10.1021/acsabm.9b00363

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate) Reviewed

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019.10

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    DOI: 10.1021/acsabm.9b00363

  • Controlling the Hydration Structure with a Small Amount of Fluorine to Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate) Reviewed

    Ryohei Koguchi, Katja Jankova, Noriko Tanabe, Yosuke Amino, Yuki Hayasaka, Daisuke Kobayashi, Tatsuya Miyajima, Kyoko Yamamoto, Masaru Tanaka

    Biomacromolecules   20 ( 6 )   2265 - 2275   2019.6

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    DOI: 10.1021/acs.biomac.9b00201

  • Controlling the Hydration Structure with a Small Amount of Fluorine To Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate)

    Ryohei Koguchi, Katja Jankova, Noriko Tanabe, Yosuke Amino, Yuki Hayasaka, Daisuke Kobayashi, Tatsuya Miyajima, Kyoko Yamamoto, Masaru Tanaka

    Biomacromolecules   20 ( 6 )   2265 - 2275   2019.6

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    DOI: 10.1021/acs.biomac.9b00201

  • Controlling the Hydration Structure with a Small Amount of Fluorine to Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate) Reviewed

    Ryohei Koguchi, Katja Jankova, Noriko Tanabe, Yosuke Amino, Yuki Hayasaka, Daisuke Kobayashi, Tatsuya Miyajima, Kyoko Yamamoto, Masaru Tanaka

    Biomacromolecules   20 ( 6 )   2265 - 2275   2019.6

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    DOI: 10.1021/acs.biomac.9b00201

  • Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires Reviewed

    8 ( 10 )   2019.5

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    Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core–shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq−1). The neural interface integrated with gel-coated exterior microelectrodes preserves low impedance (1.1–3.2 Ω cm2) in a saline solution over the evaluated 5-month period. Besides the use of efficient conductive materials, surface treatment using antithrombogenic polymer tends to prevent the growth of granulation tissue, thereby facilitating clear monitoring of electrocorticograms (ECoG) in a rodent during chronic implantation. The flexible and transparent neural interface pathologically exhibits noncytotoxicity and low inflammatory response while efficiently recording evoked ECoG in a nonhuman primate via optogenetic stimulation. The proposed highly reliable interface can be employed in multifaceted approaches for translational research based on chronic implants.

    DOI: 10.1002/adhm.201900130

  • Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires Reviewed

    8 ( 10 )   2019.5

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    © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core–shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq−1). The neural interface integrated with gel-coated exterior microelectrodes preserves low impedance (1.1–3.2 Ω cm2) in a saline solution over the evaluated 5-month period. Besides the use of efficient conductive materials, surface treatment using antithrombogenic polymer tends to prevent the growth of granulation tissue, thereby facilitating clear monitoring of electrocorticograms (ECoG) in a rodent during chronic implantation. The flexible and transparent neural interface pathologically exhibits noncytotoxicity and low inflammatory response while efficiently recording evoked ECoG in a nonhuman primate via optogenetic stimulation. The proposed highly reliable interface can be employed in multifaceted approaches for translational research based on chronic implants.

    DOI: 10.1002/adhm.201900130

  • Controlling the Hydration Structure with a Small Amount of Fluorine to Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate) Reviewed

    Koguchi, R., Jankova, K., Tanabe, N., Amino, Y., Hayasaka, Y., Kobayashi, D., Miyajima, T., Yamamoto, K., Tanaka, M.

    Biomacromolecules   20 ( 6 )   2019.5

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    DOI: 10.1021/acs.biomac.9b00201

  • Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires Reviewed

    8 ( 10 )   2019.5

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    Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core–shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq−1). The neural interface integrated with gel-coated exterior microelectrodes preserves low impedance (1.1–3.2 Ω cm2) in a saline solution over the evaluated 5-month period. Besides the use of efficient conductive materials, surface treatment using antithrombogenic polymer tends to prevent the growth of granulation tissue, thereby facilitating clear monitoring of electrocorticograms (ECoG) in a rodent during chronic implantation. The flexible and transparent neural interface pathologically exhibits noncytotoxicity and low inflammatory response while efficiently recording evoked ECoG in a nonhuman primate via optogenetic stimulation. The proposed highly reliable interface can be employed in multifaceted approaches for translational research based on chronic implants.

    DOI: 10.1002/adhm.201900130

  • Analyses of equilibrium water content and blood compatibility for Poly(2-methoxyethyl acrylate) by molecular dynamics simulation Reviewed

    An Tsung Kuo, Shingo Urata, Ryohei Koguchi, Kyoko Yamamoto, Masaru Tanaka

    polymer   170   76 - 84   2019.4

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    DOI: 10.1016/j.polymer.2019.03.001

  • Analyses of equilibrium water content and blood compatibility for Poly(2-methoxyethyl acrylate) by molecular dynamics simulation Reviewed

    An-Tsung Kuo, Shingo Urata, Ryohei Koguchi, Kyoko Yamamoto, Masaru Tanaka

    Polymer   170   76 - 84   2019.4

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    DOI: 10.1016/j.polymer.2019.03.001

  • Analyses of equilibrium water content and blood compatibility for Poly(2-methoxyethyl acrylate) by molecular dynamics simulation Reviewed

    An Tsung Kuo, Shingo Urata, Ryohei Koguchi, Kyoko Yamamoto, Masaru Tanaka

    polymer   170   76 - 84   2019.4

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    DOI: 10.1016/j.polymer.2019.03.001

  • Intermediate water on calcium phosphate minerals ITS origin and role in crystal growth Reviewed

    Masahiro Okada, Emilio Satoshi Hara, Daisuke Kobayashi, Shoki Kai, Keiko Ogura, Masaru Tanaka, Takuya Matsumoto

    ACS Applied Bio Materials   2 ( 3 )   981 - 986   2019.3

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    DOI: 10.1021/acsabm.9b00014

  • Intermediate water on calcium phosphate minerals: ITS origin and role in crystal growth

    Okada, M., Hara, E.S., Kobayashi, D., Kai, S., Ogura, K., Tanaka, M., Matsumoto, T.

    ACS Applied Bio Materials   2 ( 3 )   981 - 986   2019.3

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    DOI: 10.1021/acsabm.9b00014

  • Intermediate Water on Calcium Phosphate Minerals: Its Origin and Role in Crystal Growth Reviewed

    Masahiro Okada, Emilio Satoshi Hara, Daisuke Kobayashi, Shoki Kai, Keiko Ogura, Masaru Tanaka, Takuya Matsumoto

    ACS Applied Bio Materials   2   981 - 986   2019.3

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    DOI: 10.1021/acsabm.9b00014

  • Intermediate water on calcium phosphate minerals ITS origin and role in crystal growth Reviewed

    Masahiro Okada, Emilio Satoshi Hara, Daisuke Kobayashi, Shoki Kai, Keiko Ogura, Masaru Tanaka, Takuya Matsumoto

    ACS Applied Bio Materials   2 ( 3 )   981 - 986   2019.3

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    DOI: 10.1021/acsabm.9b00014

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility Reviewed

    Daiki Murakami, Nami Mawatari, Toshiki Sonoda, Aki Kashiwazaki, Masaru Tanaka

    Langmuir   35 ( 7 )   2808 - 2813   2019.2

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    DOI: 10.1021/acs.langmuir.8b02971

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility

    Daiki Murakami, Nami Mawatari, Toshiki Sonoda, Aki Kashiwazaki, Masaru Tanaka

    Langmuir   35 ( 7 )   2808 - 2813   2019.2

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    DOI: 10.1021/acs.langmuir.8b02971

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility Reviewed

    Murakami, D., Mawatari, N., Sonoda, T., Kashiwazaki, A., Tanaka, M.

    Langmuir   35 ( 7 )   2808 - 2813   2019.2

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    DOI: 10.1021/acs.langmuir.8b02971

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility Reviewed

    Daiki Murakami, Nami Mawatari, Toshiki Sonoda, Aki Kashiwazaki, Masaru Tanaka

    Langmuir   35 ( 7 )   2808 - 2813   2019.2

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    DOI: 10.1021/acs.langmuir.8b02971

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers Reviewed

    Daiki Murakami, Yuto Segami, Tomoya Ueda, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   2019.1

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    DOI: 10.1080/09205063.2019.1680930

  • Design of Polymeric Biomaterials: The "Intermediate Water Concept"

    Masaru Tanaka, Shingo Kobayashi, Daiki Murakami, Fumihiro Aratsu, Aki Kashiwazaki, Takashi Hoshiba, Kazuki Fukushima

    Bulletin of the Chemical Society of Japan   92 ( 12 )   2043 - 2057   2019.1

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    Design of Polymeric Biomaterials: The "Intermediate Water Concept"
    © 2019 The Chemical Society of Japan. When biomaterials come into contact with biological fluids, water molecules immediately adsorb onto the surface of the materials. To understand the origin of the crucial roles of water molecules in biological interfaces, it is necessary to relate particular states of hydration water to various physicochemical properties of hydrated polymers. Here, advances in the inter-mediate water concept are reviewed. This account provides an overview of the progress made in the design of multi-functional biomedical polymers by controlling the bio-interfacial water states. Using principles of intermediate water, which is common in hydrated biopolymers and only biocompatible synthetic polymers, we found the synthetic methodology to create novel biocompatible polymers moves toward a more high-throughput way.

    DOI: 10.1246/bcsj.20190274

  • Design of Polymeric Biomaterials The "Intermediate Water Concept" Reviewed

    Masaru Tanaka, Shingo Kobayashi, Daiki Murakami, Fumihiro Aratsu, Aki Kashiwazaki, Takashi Hoshiba, Kazuki Fukushima

    Bulletin of the Chemical Society of Japan   92 ( 12 )   2043 - 2057   2019.1

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    DOI: 10.1246/bcsj.20190274

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers Reviewed

    Daiki Murakami, Yuto Segami, Tomoya Ueda, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   2019.1

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    DOI: 10.1080/09205063.2019.1680930

  • Design of Polymeric Biomaterials The "Intermediate Water Concept" Reviewed

    Masaru Tanaka, Shingo Kobayashi, Daiki Murakami, Fumihiro Aratsu, Aki Kashiwazaki, Takashi Hoshiba, Kazuki Fukushima

    Bulletin of the Chemical Society of Japan   92 ( 12 )   2043 - 2057   2019.1

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    DOI: 10.1246/bcsj.20190274

  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping Reviewed

    Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, Takao Someya

    Science Advances   4 ( 10 )   2018.10

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    DOI: 10.1126/sciadv.aau2426

  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping

    Masaru Tanaka

    Science Advances   2018.10

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  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping Reviewed

    Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, Takao Someya

    Science Advances   4 ( 10 )   2018.10

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    DOI: 10.1126/sciadv.aau2426

  • A Nonthrombogenic, Stretchable, Active Multielectrode Array using Organic Electrochemical Transistors Reviewed

    W. Lee, S. Kobayashi, M. Nagase, Y. Jimbo, I. Saito, Y. Inoue, T. Yambe, M. Sekino, G. G Malliaras, T. Yokota, M. Tanaka, T. Someya

    Science Advances   4 ( 10 )   eaau2426   2018.10

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    A Nonthrombogenic, Stretchable, Active Multielectrode Array using Organic Electrochemical Transistors

    DOI: 10.1126/sciadv.aau2426

  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping Reviewed

    Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, Takao Someya

    Science Advances   4 ( 10 )   2018.10

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    DOI: 10.1126/sciadv.aau2426

  • Hydrogel Preparation and Characterisation Derived from Chitosan and Amino Functional Monomers for Biomedical Applications Reviewed

    Masaru Tanaka

    Journal of Materials Chemistry B   6   5115   2018.8

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  • Hydrogel Preparation and Characterisation Derived from Chitosan and Amino Functional Monomers for Biomedical Applications Reviewed

    Masaru Tanaka

    Journal of Materials Chemistry B   6   5115   2018.8

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  • Newly developed controlled release subcutaneous formulation for tramadol hydrochloride Reviewed

    Mostafa Mabrouk, Hanan H. Beherei, Shaimaa ElShebiney, Masaru Tanaka

    Saudi Pharmaceutical Journal   26 ( 4 )   585 - 592   2018.5

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    DOI: 10.1016/j.jsps.2018.01.014

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface Reviewed

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   4 ( 5 )   1591 - 1597   2018.5

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    DOI: 10.1021/acsbiomaterials.8b00081

  • Newly developed controlled release subcutaneous formulation for tramadol hydrochloride Reviewed

    Mostafa Mabrouk, Hanan H. Beherei, Shaimaa ElShebiney, Masaru Tanaka

    Saudi Pharmaceutical Journal   26 ( 4 )   585 - 592   2018.5

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    DOI: 10.1016/j.jsps.2018.01.014

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface Reviewed

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   4 ( 5 )   1591 - 1597   2018.5

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    DOI: 10.1021/acsbiomaterials.8b00081

  • Newly developed controlled release subcutaneous formulation for tramadol hydrochloride Reviewed

    Mostafa Mabrouk, Hanan H. Beherei, Shaimaa ElShebiney, Masaru Tanaka

    Saudi Pharmaceutical Journal   26 ( 4 )   585 - 592   2018.5

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    DOI: 10.1016/j.jsps.2018.01.014

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science & Engineering   2018.4

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    DOI: 10.1021/acsbiomaterials.8b00081

  • Chondrocyte shapes and detachment on a thermoresponsive poly(2-methoxyethyl acrylate) analog for the development of new chondrocytes subculture substrate Reviewed

    Takashi Hoshiba, Kazuhiro Sato, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Chemistry Letters   47 ( 1 )   107 - 109   2018.1

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    DOI: 10.1246/cl.170889

  • Designing smart biomaterials for tissue engineering Reviewed

    Ferdous Khan, Masaru Tanaka

    International Journal of Molecular Sciences   19 ( 1 )   2018.1

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    DOI: 10.3390/ijms19010017

  • Designing smart biomaterials for tissue engineering Reviewed

    Ferdous Khan, Masaru Tanaka

    International journal of molecular sciences   19 ( 1 )   2018.1

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    DOI: 10.3390/ijms19010017

  • Design of multifunctional soft biomaterials Based on the intermediate water concept

    Masaru Tanaka

    New Polymeric Materials Based on Element-Blocks   423 - 432   2018.1

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    DOI: 10.1007/978-981-13-2889-3_23

  • Chondrocyte shapes and detachment on a thermoresponsive poly(2-methoxyethyl acrylate) analog for the development of new chondrocytes subculture substrate Reviewed

    Takashi Hoshiba, Kazuhiro Sato, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Chemistry Letters   47 ( 1 )   107 - 109   2018.1

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    DOI: 10.1246/cl.170889

  • Analysis of interaction between interfacial structure and fibrinogen at blood-compatible polymer/water interface Reviewed

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Frontiers in Chemistry   6   2018.1

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    DOI: 10.3389/fchem.2018.00542

  • A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications Reviewed

    Ferdous Khan, Fumihiro Aratsu, Shingo Kobayashi, Masaru Tanaka

    Journal of Materials Chemistry B   6 ( 31 )   5115 - 5129   2018.1

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    DOI: 10.1039/c8tb00865e

  • Designing smart biomaterials for tissue engineering Reviewed

    Ferdous Khan, Masaru Tanaka

    International journal of molecular sciences   19 ( 1 )   2018.1

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    DOI: 10.3390/ijms19010017

  • Design of multifunctional soft biomaterials Based on the intermediate water concept

    Masaru Tanaka

    New Polymeric Materials Based on Element-Blocks   423 - 432   2018.1

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    DOI: 10.1007/978-981-13-2889-3_23

  • Chondrocyte shapes and detachment on a thermoresponsive poly(2-methoxyethyl acrylate) analog for the development of new chondrocytes subculture substrate Reviewed

    Takashi Hoshiba, Kazuhiro Sato, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Chemistry Letters   47 ( 1 )   107 - 109   2018.1

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    DOI: 10.1246/cl.170889

  • Analysis of interaction between interfacial structure and fibrinogen at blood-compatible polymer/water interface Reviewed

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Frontiers in Chemistry   6   2018.1

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    DOI: 10.3389/fchem.2018.00542

  • A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications Reviewed

    Ferdous Khan, Fumihiro Aratsu, Shingo Kobayashi, Masaru Tanaka

    Journal of Materials Chemistry B   6 ( 31 )   5115 - 5129   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c8tb00865e

  • Design of multifunctional soft biomaterials Based on the intermediate water concept

    Masaru Tanaka

    New Polymeric Materials Based on Element-Blocks   423 - 432   2018.1

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    Language:English  

    DOI: 10.1007/978-981-13-2889-3_23

  • Analysis of interaction between interfacial structure and fibrinogen at blood-compatible polymer/water interface Reviewed

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Frontiers in Chemistry   6   2018.1

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    DOI: 10.3389/fchem.2018.00542

  • A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications Reviewed

    Ferdous Khan, Fumihiro Aratsu, Shingo Kobayashi, Masaru Tanaka

    Journal of Materials Chemistry B   6 ( 31 )   5115 - 5129   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c8tb00865e

  • Designing smart biomaterials for tissue engineering Reviewed

    Ferdous Khan, Masaru Tanaka

    International Journal of Molecular Sciences   19 ( 1 )   2018.1

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    DOI: 10.3390/ijms19010017

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers Reviewed

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Macromolecular Bioscience   17 ( 12 )   2017.12

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    DOI: 10.1002/mabi.201700297

  • Poly(ω-methoxyalkyl acrylate)s: Nonthrombogenic Polymer Family with Tunable Protein Adsorption Reviewed

    18 ( 12 )   4214 - 4223   2017.12

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    DOI: 10.1021/acs.biomac.7b01247

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers Reviewed

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    MACROMOLECULAR BIOSCIENCE   17 ( 12 )   2017.12

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    DOI: 10.1002/mabi.201700304

  • Poly(ω-methoxyalkyl acrylate)s Nonthrombogenic Polymer Family with Tunable Protein Adsorption Reviewed

    18 ( 12 )   4214 - 4223   2017.12

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    A series of polyacrylates with different n-alkyl side chain lengths (1 to 6, and 12 carbons) and a ω-methoxy terminal group (poly(ω-methoxyalkyl acrylate): PMCxA) were prepared to study their nonthrombogenicity using human platelet adhesion, micro bicinchoninic acid (micro BCA) protein assay, and enzyme-linked immunosorbent assay (ELISA) tests. In all cases, human platelet adhesion was suppressed on the PMCxA-coated substrates, and the number of human platelets adhered to the PMC3A (poly(3-methoxypropyl acrylate))-coated surface was comparable to that of commercialized nonthrombogenic coating agent poly(2-methoxyethyl acrylate) (PMEA, equal to PMC2A). The amount of protein adsorbed onto the PMCxA was investigated by micro BCA using bovine serum albumin (BSA) and human fibrinogen (hFbn), revealing that PMC3A exhibited significantly high resistance to nonspecific BSA adsorption. Additionally, the amount of hFbn adsorbed onto the PMC3A was suppressed to the same extent as PMEA. The exposure degree of platelet adhesion sites in adsorbed hFbn was evaluated using an ELISA test, and the degree on the PMCxA with three to six methylene carbons was comparable to the PMEA. The hydration water structure in the hydrated PMCxA was also characterized using differential scanning calorimetry (DSC). The amount of intermediate water, which is the hydration water molecules that moderately interact with the polymer matrix, was maximum in the PMEA with two methylene run lengths, whereas the amount decreased by increasing the number of methyelnes in the side chain. The amount of adsorbed protein increased with a decrease in the amount of intermediate water, suggesting that the protein adsorption amount is tunable by simply changing the number of methylene carbons in the side chain. The present study revealed that poly(ω-methoxyalkyl acrylate)s are useful for blood-contacting medical devices, and PMC3A is the best mode of PMCxA to apply as an antiprotein adsorption coating agent.

    DOI: 10.1021/acs.biomac.7b01247

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers Reviewed

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Macromolecular Bioscience   17 ( 12 )   2017.12

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    DOI: 10.1002/mabi.201700297

  • Poly(ω-methoxyalkyl acrylate)s Nonthrombogenic Polymer Family with Tunable Protein Adsorption Reviewed

    18 ( 12 )   4214 - 4223   2017.12

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    A series of polyacrylates with different n-alkyl side chain lengths (1 to 6, and 12 carbons) and a ω-methoxy terminal group (poly(ω-methoxyalkyl acrylate): PMCxA) were prepared to study their nonthrombogenicity using human platelet adhesion, micro bicinchoninic acid (micro BCA) protein assay, and enzyme-linked immunosorbent assay (ELISA) tests. In all cases, human platelet adhesion was suppressed on the PMCxA-coated substrates, and the number of human platelets adhered to the PMC3A (poly(3-methoxypropyl acrylate))-coated surface was comparable to that of commercialized nonthrombogenic coating agent poly(2-methoxyethyl acrylate) (PMEA, equal to PMC2A). The amount of protein adsorbed onto the PMCxA was investigated by micro BCA using bovine serum albumin (BSA) and human fibrinogen (hFbn), revealing that PMC3A exhibited significantly high resistance to nonspecific BSA adsorption. Additionally, the amount of hFbn adsorbed onto the PMC3A was suppressed to the same extent as PMEA. The exposure degree of platelet adhesion sites in adsorbed hFbn was evaluated using an ELISA test, and the degree on the PMCxA with three to six methylene carbons was comparable to the PMEA. The hydration water structure in the hydrated PMCxA was also characterized using differential scanning calorimetry (DSC). The amount of intermediate water, which is the hydration water molecules that moderately interact with the polymer matrix, was maximum in the PMEA with two methylene run lengths, whereas the amount decreased by increasing the number of methyelnes in the side chain. The amount of adsorbed protein increased with a decrease in the amount of intermediate water, suggesting that the protein adsorption amount is tunable by simply changing the number of methylene carbons in the side chain. The present study revealed that poly(ω-methoxyalkyl acrylate)s are useful for blood-contacting medical devices, and PMC3A is the best mode of PMCxA to apply as an antiprotein adsorption coating agent.

    DOI: 10.1021/acs.biomac.7b01247

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers Reviewed

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Macromolecular Bioscience   17 ( 12 )   2017.12

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    DOI: 10.1002/mabi.201700297

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion A Promising Material for Resorbable Vascular Grafts and Stents Reviewed

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    Biomacromolecules   18 ( 11 )   3834 - 3843   2017.11

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    DOI: 10.1021/acs.biomac.7b01210

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents Reviewed

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    BIOMACROMOLECULES   18 ( 11 )   3834 - 3843   2017.11

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    DOI: 10.1021/acs.biomac.7b01210

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion A Promising Material for Resorbable Vascular Grafts and Stents Reviewed

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    Biomacromolecules   18 ( 11 )   3834 - 3843   2017.11

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    DOI: 10.1021/acs.biomac.7b01210

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts Reviewed

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    European Polymer Journal   95   728 - 736   2017.10

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    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts Reviewed

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    European Polymer Journal   95   728 - 736   2017.10

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    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts Reviewed

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    European Polymer Journal   95   728 - 736   2017.10

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    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts Reviewed

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    EUROPEAN POLYMER JOURNAL   95   728 - 736   2017.10

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    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers Reviewed

    Takashi Hoshiba, Ayano Yoshihiro, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   986 - 999   2017.8

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    DOI: 10.1080/09205063.2017.1312738

  • Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers mechanisms underlying the effect of lateral packing density on bioinertness Reviewed

    Taito Sekine, Syifa Asatyas, Chikako Sato, Shigeaki Morita, Masaru Tanaka, Tomohiro Hayashi

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   1231 - 1243   2017.8

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    DOI: 10.1080/09205063.2017.1303120

  • Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers Reviewed

    Takashi Hoshiba, Ayano Yoshihiro, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   986 - 999   2017.8

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    DOI: 10.1080/09205063.2017.1312738

  • Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers mechanisms underlying the effect of lateral packing density on bioinertness Reviewed

    Taito Sekine, Syifa Asatyas, Chikako Sato, Shigeaki Morita, Masaru Tanaka, Tomohiro Hayashi

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   1231 - 1243   2017.8

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    DOI: 10.1080/09205063.2017.1303120

  • Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers Reviewed

    Takashi Hoshiba, Ayano Yoshihiro, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   986 - 999   2017.8

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    DOI: 10.1080/09205063.2017.1312738

  • Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers mechanisms underlying the effect of lateral packing density on bioinertness Reviewed

    Taito Sekine, Syifa Asatyas, Chikako Sato, Shigeaki Morita, Masaru Tanaka, Tomohiro Hayashi

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   1231 - 1243   2017.8

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    DOI: 10.1080/09205063.2017.1303120

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime Reviewed

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    Annals of Biomedical Engineering   45 ( 5 )   1352 - 1364   2017.5

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    DOI: 10.1007/s10439-016-1781-5

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester): A Candidate for Blood-Compatible Polymers Reviewed

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    BIOMACROMOLECULES   18 ( 5 )   1609 - 1616   2017.5

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    DOI: 10.1021/acs.biomac.7b00221

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime Reviewed

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    ANNALS OF BIOMEDICAL ENGINEERING   45 ( 5 )   1352 - 1364   2017.5

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    DOI: 10.1007/s10439-016-1781-5

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester) A Candidate for Blood-Compatible Polymers Reviewed

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    Biomacromolecules   18 ( 5 )   1609 - 1616   2017.5

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    DOI: 10.1021/acs.biomac.7b00221

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime Reviewed

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    Annals of Biomedical Engineering   45 ( 5 )   1352 - 1364   2017.5

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    DOI: 10.1007/s10439-016-1781-5

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester) A Candidate for Blood-Compatible Polymers Reviewed

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    Biomacromolecules   18 ( 5 )   1609 - 1616   2017.5

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    DOI: 10.1021/acs.biomac.7b00221

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime Reviewed

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    Annals of Biomedical Engineering   45 ( 5 )   1352 - 1364   2017.5

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    DOI: 10.1007/s10439-016-1781-5

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy Reviewed International journal

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   19 ( 2 )   1389 - 1394   2017.4

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    DOI: 10.1039/c6cp07322k

  • Applications of functionalized biodegradable polymers in tissue engineering and regenerative medicine Reviewed

    Fukushima Kazuki, Inoue Yuto, Haga Yuta, Oji Masashi, Takaoka Shunya, Sato Chikako, Tsuchiya Haruka, Tanaka Masaru

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   253   2017.4

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    Applications of functionalized biodegradable polymers in tissue engineering and regenerative medicine

  • Design Concept of Dialyzer Biomaterials How to Find Biocompatible Polymers Based on the Biointerfacial Water Structure Reviewed

    Masaru Tanaka

    Contributions to Nephrology   189   137 - 143   2017.1

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    DOI: 10.1159/000451043

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    PHYSICAL CHEMISTRY CHEMICAL PHYSICS   19 ( 2 )   1389 - 1394   2017.1

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    DOI: 10.1039/c6cp07322k

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   19 ( 2 )   1389 - 1394   2017.1

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    DOI: 10.1039/c6cp07322k

  • Design Concept of Dialyzer Biomaterials How to Find Biocompatible Polymers Based on the Biointerfacial Water Structure Reviewed

    Masaru Tanaka

    Contributions to Nephrology   189   137 - 143   2017.1

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    DOI: 10.1159/000451043

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   19 ( 2 )   1389 - 1394   2017

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    DOI: 10.1039/c6cp07322k

  • Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces Reviewed

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   2 ( 12 )   2122 - 2126   2016.12

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    DOI: 10.1021/acsbiomaterials.6b00415

  • Interfacial Structures and Fibrinogen Adsorption at Blood Compatible Polymer/Water Interfaces Reviewed

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS BIOMATERIALS SCIENCE & ENGINEERING   2 ( 12 )   2122 - 2126   2016.12

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    DOI: 10.1021/acsbiomaterials.6b00415

  • Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces Reviewed

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   2 ( 12 )   2122 - 2126   2016.12

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    DOI: 10.1021/acsbiomaterials.6b00415

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst Reviewed

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    European Polymer Journal   84   750 - 758   2016.11

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    DOI: 10.1016/j.eurpolymj.2016.08.008

  • 再生医療・組織工学 中間水含有高分子による軟骨細胞の形態制御を通じた機能維持可能な継代培養基板の開発

    丸山 寛花, 干場 隆志, 佐藤 一博, 陳 国平, 田中 賢

    日本バイオマテリアル学会大会予稿集   シンポジウム2016   97 - 97   2016.11

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  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene Reviewed

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    MACROMOLECULES   49 ( 21 )   8154 - 8161   2016.11

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    DOI: 10.1021/acs.macromol.6b01829

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption Suppressing Poly(2-methoxyethyl acrylate) Analogs Reviewed

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    BIOMACROMOLECULES   17 ( 11 )   3808 - 3815   2016.11

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    DOI: 10.1021/acs.biomac.6b01340

  • Integrin-independent Cell Adhesion Substrates: Possibility of Applications for Mechanobiology Research Reviewed

    Takashi Hoshiba, Masaru Tanaka

    ANALYTICAL SCIENCES   32 ( 11 )   1151 - 1158   2016.11

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    DOI: 10.2116/analsci.32.1151

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells Reviewed

    Takashi Hoshiba, Masaru Tanaka

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   1863 ( 11 )   2749 - 2757   2016.11

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    DOI: 10.1016/j.bbamcr.2016.08.009

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst Reviewed

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    EUROPEAN POLYMER JOURNAL   84   750 - 758   2016.11

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    DOI: 10.1016/j.eurpolymj.2016.08.008

  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene Reviewed

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   49 ( 21 )   8154 - 8161   2016.11

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    DOI: 10.1021/acs.macromol.6b01829

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption-Suppressing Poly(2-methoxyethyl acrylate) Analogs Reviewed

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    Biomacromolecules   17 ( 11 )   3808 - 3815   2016.11

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    DOI: 10.1021/acs.biomac.6b01340

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels Mechanism of 5-fluorouracil resistance in colorectal tumor cells Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochimica et Biophysica Acta - Molecular Cell Research   1863 ( 11 )   2749 - 2757   2016.11

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    DOI: 10.1016/j.bbamcr.2016.08.009

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst Reviewed

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    European Polymer Journal   84   750 - 758   2016.11

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    DOI: 10.1016/j.eurpolymj.2016.08.008

  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene Reviewed

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   49 ( 21 )   8154 - 8161   2016.11

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    DOI: 10.1021/acs.macromol.6b01829

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption-Suppressing Poly(2-methoxyethyl acrylate) Analogs Reviewed

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    Biomacromolecules   17 ( 11 )   3808 - 3815   2016.11

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    DOI: 10.1021/acs.biomac.6b01340

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels Mechanism of 5-fluorouracil resistance in colorectal tumor cells Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochimica et Biophysica Acta - Molecular Cell Research   1863 ( 11 )   2749 - 2757   2016.11

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    DOI: 10.1016/j.bbamcr.2016.08.009

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst Reviewed

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    European Polymer Journal   84   750 - 758   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.eurpolymj.2016.08.008

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels Mechanism of 5-fluorouracil resistance in colorectal tumor cells Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochimica et Biophysica Acta - Molecular Cell Research   1863 ( 11 )   2749 - 2757   2016.11

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    DOI: 10.1016/j.bbamcr.2016.08.009

  • H. Choi, M. Tanaka, K. Sugimoto, Difference in cell proliferation and spontaneous mediator release between two mast cell lines, NCL-2 and RBL-2H3 on honeycomb-like structured film Invited Reviewed International journal

    Masaru Tanaka

    Journal of Nanotechnology: Nanomedicine & Nanobiotechnology   3 ( 009 )   2016.10

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  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. Reviewed

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   145   586 - 596   2016.9

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    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. Reviewed

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    COLLOIDS AND SURFACES B-BIOINTERFACES   145   586 - 596   2016.9

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    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. Reviewed

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   145   586 - 596   2016.9

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    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. Reviewed

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   145   586 - 596   2016.9

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    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells Reviewed

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    Journal of Bioactive and Compatible Polymers   31 ( 4 )   361 - 372   2016.7

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    DOI: 10.1177/0883911515618976

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells Reviewed

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS   31 ( 4 )   361 - 372   2016.7

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    DOI: 10.1177/0883911515618976

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells Reviewed

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    Journal of Bioactive and Compatible Polymers   31 ( 4 )   361 - 372   2016.7

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    DOI: 10.1177/0883911515618976

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells Reviewed

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    Journal of Bioactive and Compatible Polymers   31 ( 4 )   361 - 372   2016.7

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    DOI: 10.1177/0883911515618976

  • In vitro endothelialization test of biomaterials using immortalized endothelial cells Reviewed

    Ken Kono, Hitomi Hiruma, Shingo Kobayashi, Yoji Sato, Masaru Tanaka, Rumi Sawada, Shingo Niimi

    PLoS One   11 ( 6 )   2016.6

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    DOI: 10.1371/journal.pone.0158289

  • In Vitro Endothelialization Test of Biomaterials Using Immortalized Endothelial Cells Reviewed

    Ken Kono, Hitomi Hiruma, Shingo Kobayashi, Yoji Sato, Masaru Tanaka, Rumi Sawada, Shingo Niimi

    PLOS ONE   11 ( 6 )   2016.6

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    DOI: 10.1371/journal.pone.0158289

  • In vitro endothelialization test of biomaterials using immortalized endothelial cells Reviewed

    Ken Kono, Hitomi Hiruma, Shingo Kobayashi, Yoji Sato, Masaru Tanaka, Rumi Sawada, Shingo Niimi

    PloS one   11 ( 6 )   2016.6

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    DOI: 10.1371/journal.pone.0158289

  • In vitro endothelialization test of biomaterials using immortalized endothelial cells Reviewed

    Ken Kono, Hitomi Hiruma, Shingo Kobayashi, Yoji Sato, Masaru Tanaka, Rumi Sawada, Shingo Niimi

    PLoS One   11 ( 6 )   2016.6

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    DOI: 10.1371/journal.pone.0158289

  • Regioselective Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side Chains. Reviewed

    Shingo Kobayashi, Kousaku Fukuda, Maiko Kataoka, Masaru Tanaka

    Macromolecules   49 ( 7 )   2493 - 2501   2016.4

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    DOI: 10.1021/acs.macromol.6b00273

  • Regioselective Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side Chains. Reviewed

    Shingo Kobayashi, Kousaku Fukuda, Maiko Kataoka, Masaru Tanaka

    MACROMOLECULES   49 ( 7 )   2493 - 2501   2016.4

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    DOI: 10.1021/acs.macromol.6b00273

  • Regioselective Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side Chains. Reviewed

    Shingo Kobayashi, Kousaku Fukuda, Maiko Kataoka, Masaru Tanaka

    Macromolecules   49 ( 7 )   2493 - 2501   2016.4

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    DOI: 10.1021/acs.macromol.6b00273

  • Adhesion-based simple capture and recovery of circulating tumor cells using a blood-compatible and thermo-responsive polymer-coated substrate Reviewed

    Takashi Hoshiba, Toshihiko Orui, Chiho Endo, Kazuhiro Sato, Ayano Yoshihiro, Yasuhisa Minagawa, Masaru Tanaka

    RSC Advances   6 ( 92 )   89103 - 89112   2016.1

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    DOI: 10.1039/c6ra15229e

  • Integrin-independent cell adhesion substrates Possibility of applications for mechanobiology research Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Analytical Sciences   32 ( 11 )   1151 - 1158   2016.1

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    DOI: 10.2116/analsci.32.1151

  • Decellularized extracellular matrix as an in vitro model to study the comprehensive roles of the ECM in stem cell differentiation Reviewed

    Takashi Hoshiba, Guoping Chen, Chiho Endo, Hiroka Maruyama, Miyuki Wakui, Eri Nemoto, Naoki Kawazoe, Masaru Tanaka

    Stem Cells International   2016   2016.1

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    DOI: 10.1155/2016/6397820

  • Adhesion-based simple capture and recovery of circulating tumor cells using a blood-compatible and thermo-responsive polymer-coated substrate Reviewed

    Takashi Hoshiba, Toshihiko Orui, Chiho Endo, Kazuhiro Sato, Ayano Yoshihiro, Yasuhisa Minagawa, Masaru Tanaka

    RSC Advances   6 ( 92 )   89103 - 89112   2016.1

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    DOI: 10.1039/c6ra15229e

  • Integrin-independent cell adhesion substrates Possibility of applications for mechanobiology research Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Analytical Sciences   32 ( 11 )   1151 - 1158   2016.1

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    DOI: 10.2116/analsci.32.1151

  • Decellularized extracellular matrix as an in vitro model to study the comprehensive roles of the ECM in stem cell differentiation Reviewed

    Takashi Hoshiba, Guoping Chen, Chiho Endo, Hiroka Maruyama, Miyuki Wakui, Eri Nemoto, Naoki Kawazoe, Masaru Tanaka

    Stem Cells International   2016   2016.1

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    DOI: 10.1155/2016/6397820

  • Adhesion-based simple capture and recovery of circulating tumor cells using a blood-compatible and thermo-responsive polymer-coated substrate Reviewed

    Takashi Hoshiba, Toshihiko Orui, Chiho Endo, Kazuhiro Sato, Ayano Yoshihiro, Yasuhisa Minagawa, Masaru Tanaka

    RSC Advances   6 ( 92 )   89103 - 89112   2016.1

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    DOI: 10.1039/c6ra15229e

  • Integrin-independent cell adhesion substrates Possibility of applications for mechanobiology research Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Analytical Sciences   32 ( 11 )   1151 - 1158   2016.1

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    DOI: 10.2116/analsci.32.1151

  • Design Concept of Dialyzer Biomaterials How to Find Biocompatible Polymers Based on the Biointerfacial Water Structure Reviewed

    Masaru Tanaka

    Contributions to Nephrology   189   137 - 143   2016.1

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    DOI: 10.1159/000451043

  • Decellularized extracellular matrix as an in vitro model to study the comprehensive roles of the ECM in stem cell differentiation Reviewed

    Takashi Hoshiba, Guoping Chen, Chiho Endo, Hiroka Maruyama, Miyuki Wakui, Eri Nemoto, Naoki Kawazoe, Masaru Tanaka

    Stem Cells International   2016   2016.1

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    DOI: 10.1155/2016/6397820

  • Decellularized extracellular matrix (ECM) as an in vitro model to study the comprehensive roles of the ECM in stem cell differentiation Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Stem Cells International   2016 ( 2016 )   2016

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  • Integrin-independent cell adhesion substrates:Possibility of applications for mechanobiology research Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Analytical Sciences   32   1151   2016

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  • Difference in cell proliferation and spontaneous mediator release between two mast cell lines, NCL-2 and RBL-2H3 on honeycomb-like structured film Reviewed

    Masaru Tanaka

    HSOA Journal of Nanotechnology: Nanomedicine & Nanobiotechnology   3 ( 009 )   2016

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  • Decellularized extracellular matrix (ECM) as an in vitro model to study the comprehensive roles of the ECM in stem cell differentiation Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Stem Cells International   2016 ( 2016 )   2016

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  • Integrin-independent cell adhesion substrates:Possibility of applications for mechanobiology research Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Analytical Sciences   32   1151   2016

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  • Difference in cell proliferation and spontaneous mediator release between two mast cell lines, NCL-2 and RBL-2H3 on honeycomb-like structured film Reviewed

    Masaru Tanaka

    HSOA Journal of Nanotechnology: Nanomedicine & Nanobiotechnology   3 ( 009 )   2016

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  • Decellularized extracellular matrix (ECM) as an in vitro model to study the comprehensive roles of the ECM in stem cell differentiation Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Stem Cells International   2016 ( 2016 )   2016

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  • Integrin-independent cell adhesion substrates:Possibility of applications for mechanobiology research Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Analytical Sciences   32   1151   2016

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  • Difference in cell proliferation and spontaneous mediator release between two mast cell lines, NCL-2 and RBL-2H3 on honeycomb-like structured film Reviewed

    Masaru Tanaka

    HSOA Journal of Nanotechnology: Nanomedicine & Nanobiotechnology   3 ( 009 )   2016

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  • Construction of a blood-compatible interface based on surface segregation in a polymer blend Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    Polymer   78   219 - 224   2015.11

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    DOI: 10.1016/j.polymer.2015.10.001

  • 中間水を有する高分子基板による軟骨細胞の形態制御を通じた機能維持の試み

    丸山 寛花, 干場 隆志, 佐藤 一博, 陳 国平, 田中 賢

    日本バイオマテリアル学会大会予稿集   37回   130 - 130   2015.11

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  • Construction of a blood-compatible interface based on surface segregation in a polymer blend Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    POLYMER   78   219 - 224   2015.11

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    DOI: 10.1016/j.polymer.2015.10.001

  • Construction of a blood-compatible interface based on surface segregation in a polymer blend Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    polymer   78   219 - 224   2015.11

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    DOI: 10.1016/j.polymer.2015.10.001

  • Construction of a blood-compatible interface based on surface segregation in a polymer blend Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    Polymer   78   219 - 224   2015.11

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    DOI: 10.1016/j.polymer.2015.10.001

  • The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues Reviewed

    Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba, Masaru Tanaka

    Macromolecular Bioscience   15 ( 9 )   1296 - 1303   2015.9

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    DOI: 10.1002/mabi.201500078

  • The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues Reviewed

    Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba, Masaru Tanaka

    MACROMOLECULAR BIOSCIENCE   15 ( 9 )   1296 - 1303   2015.9

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    DOI: 10.1002/mabi.201500078

  • The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues Reviewed

    Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba, Masaru Tanaka

    Macromolecular Bioscience   15 ( 9 )   1296 - 1303   2015.9

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    DOI: 10.1002/mabi.201500078

  • The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues Reviewed

    Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba, Masaru Tanaka

    Macromolecular Bioscience   15 ( 9 )   1296 - 1303   2015.9

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    DOI: 10.1002/mabi.201500078

  • Fabrication of polymeric biomaterials a strategy for tissue engineering and medical devices Reviewed

    Ferdous Khan, Masaru Tanaka, Sheikh Rafi Ahmad

    Journal of Materials Chemistry B   3 ( 42 )   8224 - 8249   2015.8

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    DOI: 10.1039/c5tb01370d

  • Regulation of the Contribution of Integrin to Cell Attachment on Poly(2-Methoxyethyl Acrylate) (PMEA) Analogous Polymers for Attachment-Based Cell Enrichment Reviewed

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Toshihiko Orui, Takayuki Otaki, Ayano Yoshihiro, Masaru Tanaka

    PLOS ONE   10 ( 8 )   2015.8

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    DOI: 10.1371/journal.pone.0136066

  • Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development Reviewed

    Takashi Hoshiba, Takayuki Otaki, Eri Nemoto, Hiroka Maruyama, Masaru Tanaka

    ACS APPLIED MATERIALS & INTERFACES   7 ( 32 )   18096 - 18103   2015.8

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    DOI: 10.1021/acsami.5b05210

  • Regulation of the contribution of integrin to Cell attachment on poly(2-methoxyethyl acrylate) (PMEA) analogous polymers for attachment-based cell enrichment Reviewed

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Toshihiko Orui, Takayuki Otaki, Ayano Yoshihiro, Masaru Tanaka

    PloS one   10 ( 8 )   2015.8

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    DOI: 10.1371/journal.pone.0136066

  • Fabrication of polymeric biomaterials a strategy for tissue engineering and medical devices Reviewed

    Ferdous Khan, Masaru Tanaka, Sheikh Rafi Ahmad

    Journal of Materials Chemistry B   3 ( 42 )   8224 - 8249   2015.8

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    DOI: 10.1039/c5tb01370d

  • Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development Reviewed

    Takashi Hoshiba, Takayuki Otaki, Eri Nemoto, Hiroka Maruyama, Masaru Tanaka

    ACS Applied Materials and Interfaces   7 ( 32 )   18096 - 18103   2015.8

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    DOI: 10.1021/acsami.5b05210

  • Regulation of the contribution of integrin to Cell attachment on poly(2-methoxyethyl acrylate) (PMEA) analogous polymers for attachment-based cell enrichment Reviewed

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Toshihiko Orui, Takayuki Otaki, Ayano Yoshihiro, Masaru Tanaka

    PLoS One   10 ( 8 )   2015.8

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    DOI: 10.1371/journal.pone.0136066

  • Fabrication of polymeric biomaterials a strategy for tissue engineering and medical devices Reviewed

    Ferdous Khan, Masaru Tanaka, Sheikh Rafi Ahmad

    Journal of Materials Chemistry B   3 ( 42 )   8224 - 8249   2015.8

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    DOI: 10.1039/c5tb01370d

  • Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development Reviewed

    Takashi Hoshiba, Takayuki Otaki, Eri Nemoto, Hiroka Maruyama, Masaru Tanaka

    ACS Applied Materials and Interfaces   7 ( 32 )   18096 - 18103   2015.8

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    DOI: 10.1021/acsami.5b05210

  • Regulation of the contribution of integrin to Cell attachment on poly(2-methoxyethyl acrylate) (PMEA) analogous polymers for attachment-based cell enrichment Reviewed

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Toshihiko Orui, Takayuki Otaki, Ayano Yoshihiro, Masaru Tanaka

    PLoS One   10 ( 8 )   2015.8

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    DOI: 10.1371/journal.pone.0136066

  • Effect of interfacial structure on bioinert properties of poly(2-methoxyethyl acrylate)/poly(methyl methacrylate) blend films in water Reviewed

    T. Hirata, Hisao Matsuno, Daisuke Kawaguchi, N. L. Yamada, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   17 ( 26 )   17399 - 17405   2015.7

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    DOI: 10.1039/c5cp01972a

  • Evaluation of the hemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in the backbone structure based on the intermediate water concept and surface hydration Reviewed

    Kazuki Fukushima, Meng-Yu Tsai, Takayuki Ota, Yuta Haga, Kodai Matsuzaki, Yuto Inoue, Masaru Tanaka

    POLYMER JOURNAL   47 ( 7 )   469 - 473   2015.7

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    DOI: 10.1038/pj.2015.22

  • Evaluation of the hemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in the backbone structure based on the intermediate water concept and surface hydration Reviewed

    Kazuki Fukushima, Meng Yu Tsai, Takayuki Ota, Yuta Haga, Kodai Matsuzaki, Yuto Inoue, Masaru Tanaka

    Polymer Journal   47 ( 7 )   469 - 473   2015.7

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    DOI: 10.1038/pj.2015.22

  • Effect of interfacial structure on bioinert properties of poly(2-methoxyethyl acrylate)/poly(methyl methacrylate) blend films in water Reviewed

    T. Hirata, H. Matsuno, D. Kawaguchi, N. L. Yamada, M. Tanaka, K. Tanaka

    Physical Chemistry Chemical Physics   17 ( 26 )   17399 - 17405   2015.7

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    DOI: 10.1039/c5cp01972a

  • Evaluation of the hemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in the backbone structure based on the intermediate water concept and surface hydration Reviewed

    Kazuki Fukushima, Meng Yu Tsai, Takayuki Ota, Yuta Haga, Kodai Matsuzaki, Yuto Inoue, Masaru Tanaka

    Polymer Journal   47 ( 7 )   469 - 473   2015.7

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    DOI: 10.1038/pj.2015.22

  • Effect of interfacial structure on bioinert properties of poly(2-methoxyethyl acrylate)/poly(methyl methacrylate) blend films in water Reviewed

    T. Hirata, Hisao Matsuno, Daisuke Kawaguchi, N. L. Yamada, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   17 ( 26 )   17399 - 17405   2015.7

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    DOI: 10.1039/c5cp01972a

  • Evaluation of the hemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in the backbone structure based on the intermediate water concept and surface hydration Reviewed

    Kazuki Fukushima, Meng Yu Tsai, Takayuki Ota, Yuta Haga, Kodai Matsuzaki, Yuto Inoue, Masaru Tanaka

    Polymer Journal   47 ( 7 )   469 - 473   2015.7

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    DOI: 10.1038/pj.2015.22

  • Evaluation of Factors To Determine Platelet Compatibility by Using Self-Assembled Monolayers with a Chemical Gradient Reviewed

    Taito Sekine, Yusaku Tanaka, Chikako Sato, Masaru Tanaka, Tomohiro Hayashi

    Langmuir   31 ( 25 )   7100 - 7105   2015.6

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    DOI: 10.1021/acs.langmuir.5b01216

  • Evaluation of Factors To Determine Platelet Compatibility by Using Self-Assembled Mono layers with a Chemical Gradient Reviewed

    Taito Sekine, Yusaku Tanaka, Chikako Sato, Masaru Tanaka, Tomohiro Hayashi

    LANGMUIR   31 ( 25 )   7100 - 7105   2015.6

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    DOI: 10.1021/acs.langmuir.5b01216

  • Evaluation of Factors To Determine Platelet Compatibility by Using Self-Assembled Monolayers with a Chemical Gradient Reviewed

    Taito Sekine, Yusaku Tanaka, Chikako Sato, Masaru Tanaka, Tomohiro Hayashi

    Langmuir   31 ( 25 )   7100 - 7105   2015.6

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    DOI: 10.1021/acs.langmuir.5b01216

  • Effect of local chain dynamics on a bioinert interface Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Tomoyasu Hirai, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    Langmuir   31 ( 12 )   3661 - 3667   2015.3

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    DOI: 10.1021/acs.langmuir.5b00258

  • Effect of Local Chain Dynamics on a Bioinert Interface Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Tomoyasu Hirai, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    LANGMUIR   31 ( 12 )   3661 - 3667   2015.3

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    DOI: 10.1021/acs.langmuir.5b00258

  • Effect of local chain dynamics on a bioinert interface Reviewed

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Tomoyasu Hirai, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    Langmuir   31 ( 12 )   3661 - 3667   2015.3

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    DOI: 10.1021/acs.langmuir.5b00258

  • Optimization of the tissue source, malignancy, and initial substrate of tumor cell-derived matrices to increase cancer cell chemoresistance against 5-fluorouracil Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochemical and Biophysical Research Communications   457 ( 3 )   353 - 357   2015.2

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    DOI: 10.1016/j.bbrc.2014.12.116

  • Optimization of the tissue source, malignancy, and initial substrate of tumor cell-derived matrices to increase cancer cell chemoresistance against 5-fluorouracil Reviewed

    Takashi Hoshiba, Masaru Tanaka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   457 ( 3 )   353 - 357   2015.2

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    DOI: 10.1016/j.bbrc.2014.12.116

  • Design of biocompatible and biodegradable polymers based on intermediate water concept Reviewed

    Masaru Tanaka, Kazuhiro Sato, Erika Kitakami, Shingo Kobayashi, Takashi Hoshiba, Kazuki Fukushima

    POLYMER JOURNAL   47 ( 2 )   114 - 121   2015.2

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    DOI: 10.1038/pj.2014.129

  • Optimization of the tissue source, malignancy, and initial substrate of tumor cell-derived matrices to increase cancer cell chemoresistance against 5-fluorouracil Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochemical and Biophysical Research Communications   457 ( 3 )   353 - 357   2015.2

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    DOI: 10.1016/j.bbrc.2014.12.116

  • Design of biocompatible and biodegradable polymers based on intermediate water concept Reviewed

    Masaru Tanaka, Kazuhiro Sato, Erika Kitakami, Shingo Kobayashi, Takashi Hoshiba, Kazuki Fukushima

    Polymer Journal   47 ( 2 )   114 - 121   2015.2

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    DOI: 10.1038/pj.2014.129

  • Optimization of the tissue source, malignancy, and initial substrate of tumor cell-derived matrices to increase cancer cell chemoresistance against 5-fluorouracil Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochemical and Biophysical Research Communications   457 ( 3 )   353 - 357   2015.2

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    DOI: 10.1016/j.bbrc.2014.12.116

  • Design of biocompatible and biodegradable polymers based on intermediate water concept Reviewed

    Masaru Tanaka, Kazuhiro Sato, Erika Kitakami, Shingo Kobayashi, Takashi Hoshiba, Kazuki Fukushima

    Polymer Journal   47 ( 2 )   114 - 121   2015.2

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    DOI: 10.1038/pj.2014.129

  • Design of biocompatible and biodegradable polymers based on intermediate water concept Reviewed

    Masaru Tanaka, Kazuhiro Sato, Erika Kitakami, Shingo Kobayashi, Takashi Hoshiba, Kazuki Fukushima

    Polymer Journal   47 ( 2 )   114 - 121   2015.1

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    DOI: 10.1038/pj.2014.129

  • タンパク質吸着量の異なる基板による軟骨細胞の接着形態制御

    丸山 寛花, 干場 隆志, 根本 絵梨, 佐藤 一博, 陳 国平, 田中 賢

    日本バイオマテリアル学会大会予稿集   36回   127 - 127   2014.11

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  • Effect of sodium chloride on hydration structures of PMEA and P(MPC- R -BMA) Reviewed

    Shigeaki Morita, Masaru Tanaka

    Langmuir   30 ( 35 )   10698 - 10703   2014.9

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    DOI: 10.1021/la502550d

  • Effect of Sodium Chloride on Hydration Structures of PMEA and P(MPC-r-BMA) Reviewed

    Shigeaki Morita, Masaru Tanaka

    LANGMUIR   30 ( 35 )   10698 - 10703   2014.9

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    DOI: 10.1021/la502550d

  • Effect of sodium chloride on hydration structures of PMEA and P(MPC- R -BMA) Reviewed

    Shigeaki Morita, Masaru Tanaka

    Langmuir   30 ( 35 )   10698 - 10703   2014.9

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    DOI: 10.1021/la502550d

  • Facile and practical route to a versatile intermediate of substituted cyclic carbonates offering diverse smart biomaterials Reviewed

    Fukushima Kazuki, Kishi Kohei, Takaoka Shunya, Inoue Yuto, Sato Chikako, Tanaka Masaru

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   248   2014.8

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    Facile and practical route to a versatile intermediate of substituted cyclic carbonates offering diverse smart biomaterials

  • Characterization of the attachment mechanisms of tissue-derived cell lines to blood-compatible polymers Reviewed

    Takashi Hoshiba, Mayo Nikaido, Masaru Tanaka

    Advanced Healthcare Materials   3 ( 5 )   775 - 784   2014.5

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    DOI: 10.1002/adhm.201300309

  • バイオマテリアルの境界科学 血液適合性にすぐれた高分子材料の水和状態

    田中賢, 林智広, 森田成昭

    バイオマテリアル   32 ( 2 )   74 - 85   2014.5

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  • Characterization of the Attachment Mechanisms of Tissue-Derived Cell Lines to Blood-Compatible Polymers Reviewed

    Takashi Hoshiba, Mayo Nikaido, Masaru Tanaka

    ADVANCED HEALTHCARE MATERIALS   3 ( 5 )   775 - 784   2014.5

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    DOI: 10.1002/adhm.201300309

  • Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate with multinucleated formation Reviewed

    Hyunmi Choi, Masaru Tanaka, Takaaki Hiragun, Michihiro Hide, Koreaki Sugimoto

    Nanomedicine: Nanotechnology, Biology, and Medicine   10 ( 2 )   313 - 319   2014.2

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    DOI: 10.1016/j.nano.2013.08.011

  • Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate with multinucleated formation Reviewed

    Hyunmi Choi, Masaru Tanaka, Takaaki Hiragun, Michihiro Hide, Koreaki Sugimoto

    Nanomedicine: Nanotechnology, Biology, and Medicine   10 ( 2 )   313 - 319   2014.2

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    DOI: 10.1016/j.nano.2013.08.011

  • Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate with multinucleated formation Reviewed

    Hyunmi Choi, Masaru Tanaka, Takaaki Hiragun, Michihiro Hide, Koreaki Sugimoto

    Nanomedicine: Nanotechnology, Biology, and Medicine   10 ( 2 )   313 - 319   2014.2

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    DOI: 10.1016/j.nano.2013.08.011

  • Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate) Reviewed

    Erika Kitakami, Makiko Aoki, Chikako Sato, Hiroshi Ishihata, Masaru Tanaka

    BioMed Research International   2014   2014.1

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    DOI: 10.1155/2014/102648

  • 平成25年度日韓バイオマテリアル学会若手研究者交流AWARD 血液適合性高分子PMEAへのがん細胞の接着機構の解析 (特集 平成25年度日本バイオマテリアル学会各賞紹介)

    干場 隆志, 田中 賢

    バイオマテリアル : 生体材料   32 ( 1 )   39 - 41   2014.1

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  • Biocompatible 2D and 3D polymeric scaffolds for medical devices Reviewed

    Masaru Tanaka

    Horizons in Clinical Nanomedicine   229 - 253   2014.1

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    DOI: 10.4032/9789814411578

  • Biocompatible 2D and 3D polymeric scaffolds for medical devices

    Masaru Tanaka

    Horizons in Clinical Nanomedicine   229 - 253   2014.1

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    DOI: 10.4032/9789814411578

  • Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate) Reviewed

    Erika Kitakami, Makiko Aoki, Chikako Sato, Hiroshi Ishihata, Masaru Tanaka

    BioMed Research International   2014   2014.1

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    DOI: 10.1155/2014/102648

  • The morphology and functions of articular chondrocytes on a honeycomb-patterned surface Reviewed

    Joshua O. Eniwumide, Masaru Tanaka, Nobuhiro Nagai, Yuka Morita, Joost De Bruijn, Sadaaki Yamamoto, Shin Onodera, Eiji Kondo, Kazunori Yasuda, Masatsugu Shimomura

    BioMed Research International   2014   2014.1

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    DOI: 10.1155/2014/710354

  • Characterization of the attachment mechanisms of tissue-derived cell lines to blood-compatible polymers Reviewed

    Takashi Hoshiba, Mayo Nikaido, Masaru Tanaka

    Advanced Healthcare Materials   3 ( 5 )   775 - 784   2014.1

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    DOI: 10.1002/adhm.201300309

  • Biocompatible 2D and 3D polymeric scaffolds for medical devices

    Masaru Tanaka

    Horizons in Clinical Nanomedicine   229 - 253   2014.1

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    DOI: 10.4032/9789814411578

  • Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate) Reviewed

    Erika Kitakami, Makiko Aoki, Chikako Sato, Hiroshi Ishihata, Masaru Tanaka

    BioMed Research International   2014   2014.1

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    DOI: 10.1155/2014/102648

  • The morphology and functions of articular chondrocytes on a honeycomb-patterned surface Reviewed

    Joshua O. Eniwumide, Masaru Tanaka, Nobuhiro Nagai, Yuka Morita, Joost De Bruijn, Sadaaki Yamamoto, Shin Onodera, Eiji Kondo, Kazunori Yasuda, Masatsugu Shimomura

    BioMed Research International   2014   2014.1

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    DOI: 10.1155/2014/710354

  • Biocompatible 2D and 3D polymeric scaffolds for medical devices

    Masaru Tanaka

    Horizons in Clinical Nanomedicine   229 - 253   2014.1

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    DOI: 10.4032/9789814411578

  • Honeycomb-like structured film regulates mediator release from non-tumor mast cells Reviewed

    Masaru Tanaka

    European Journal of Inflammation   12   515   2014

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  • The morphology and functions of articular chondrocytes on a honeycomb-patterned surface Reviewed

    Joshua O. Eniwumide, Masaru Tanaka, Nobuhiro Nagai, Yuka Morita, Joost De Bruijn, Sadaaki Yamamoto, Shin Onodera, Eiji Kondo, Kazunori Yasuda, Masatsugu Shimomura

    BioMed Research International   2014   2014

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    DOI: 10.1155/2014/710354

  • Non-tumor mast cells cultured in vitro on a honeycomb-like structured film prpliferate with multinucleateaed formation Reviewed

    Masaru Tanaka

    Nanomedicine: Nanotechnology, Biology, and Medicine   10   313   2014

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  • Honeycomb-like structured film regulates mediator release from non-tumor mast cells Reviewed

    Masaru Tanaka

    European Journal of Inflammation   12   515   2014

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  • Non-tumor mast cells cultured in vitro on a honeycomb-like structured film prpliferate with multinucleateaed formation Reviewed

    Masaru Tanaka

    Nanomedicine: Nanotechnology, Biology, and Medicine   10   313   2014

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  • Honeycomb-like structured film regulates mediator release from non-tumor mast cells Reviewed

    Masaru Tanaka

    European Journal of Inflammation   12   515   2014

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  • Non-tumor mast cells cultured in vitro on a honeycomb-like structured film prpliferate with multinucleateaed formation Reviewed

    Masaru Tanaka

    Nanomedicine: Nanotechnology, Biology, and Medicine   10   313   2014

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  • Erratum Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: Protein adsorption, platelet adhesion, and surface forces (Physical Chemistry Chemical Physics (2012) 14 (10196-10206) DOI: 10.1039/C2CP41236E) Reviewed

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   15 ( 48 )   2013.12

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    DOI: 10.1039/c3cp90155f

  • Erratum Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: Protein adsorption, platelet adhesion, and surface forces (Physical Chemistry Chemical Physics (2012) 14 (10196-10206) DOI: 10.1039/C2CP41236E) Reviewed

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   15 ( 48 )   2013.12

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    DOI: 10.1039/c3cp90155f

  • Erratum Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: Protein adsorption, platelet adhesion, and surface forces (Physical Chemistry Chemical Physics (2012) 14 (10196-10206) DOI: 10.1039/C2CP41236E) Reviewed

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   15 ( 48 )   2013.12

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    DOI: 10.1039/c3cp90155f

  • Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochemical and Biophysical Research Communications   439 ( 2 )   291 - 296   2013.9

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    DOI: 10.1016/j.bbrc.2013.08.038

  • Microporous "honeycomb" films support enhanced bone formation in vitro Reviewed

    Mark A. Birch, Masaru Tanaka, George Kirmizidis, Sadaaki Yamamoto, Masatsugu Shimomura

    Tissue Engineering - Part A   19 ( 17-18 )   2087 - 2096   2013.9

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    DOI: 10.1089/ten.tea.2012.0729

  • Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages Reviewed

    Takashi Hoshiba, Masaru Tanaka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   439 ( 2 )   291 - 296   2013.9

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    DOI: 10.1016/j.bbrc.2013.08.038

  • Antithrombotic biodegradable polycarbonates for regenerative medicines Reviewed

    Fukushima Kazuki, Inoue Yuto, Tanaka Masaru

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   246   2013.9

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    Antithrombotic biodegradable polycarbonates for regenerative medicines

  • Microporous "honeycomb" films support enhanced bone formation in vitro Reviewed

    Mark A. Birch, Masaru Tanaka, George Kirmizidis, Sadaaki Yamamoto, Masatsugu Shimomura

    Tissue Engineering - Part A   19 ( 17-18 )   2087 - 2096   2013.9

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    DOI: 10.1089/ten.tea.2012.0729

  • Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochemical and Biophysical Research Communications   439 ( 2 )   291 - 296   2013.9

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    DOI: 10.1016/j.bbrc.2013.08.038

  • Microporous "honeycomb" films support enhanced bone formation in vitro Reviewed

    Mark A. Birch, Masaru Tanaka, George Kirmizidis, Sadaaki Yamamoto, Masatsugu Shimomura

    Tissue Engineering - Part A   19 ( 17-18 )   2087 - 2096   2013.9

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    DOI: 10.1089/ten.tea.2012.0729

  • Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages Reviewed

    Takashi Hoshiba, Masaru Tanaka

    Biochemical and Biophysical Research Communications   439 ( 2 )   291 - 296   2013.9

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    DOI: 10.1016/j.bbrc.2013.08.038

  • Microporous "honeycomb" films support enhanced bone formation in vitro Reviewed

    Mark A. Birch, Masaru Tanaka, George Kirmizidis, Sadaaki Yamamoto, Masatsugu Shimomura

    Tissue Engineering - Part A.   19 ( 17-18 )   2087 - 2096   2013.9

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    DOI: 10.1089/ten.tea.2012.0729

  • The roles of water molecules at the biointerface of medical polymers Reviewed

    Masaru Tanaka, Tomohiro Hayashi, Shigeaki Morita

    Polymer Journal   45 ( 7 )   701 - 710   2013.7

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    DOI: 10.1038/pj.2012.229

  • The roles of water molecules at the biointerface of medical polymers Reviewed

    Masaru Tanaka, Tomohiro Hayashi, Shigeaki Morita

    POLYMER JOURNAL   45 ( 7 )   701 - 710   2013.7

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    DOI: 10.1038/pj.2012.229

  • The roles of water molecules at the biointerface of medical polymers Reviewed

    Masaru Tanaka, Tomohiro Hayashi, Shigeaki Morita

    Polymer Journal   45 ( 7 )   701 - 710   2013.7

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    DOI: 10.1038/pj.2012.229

  • The roles of water molecules at the biointerface of medical polymers Reviewed

    Masaru Tanaka, Tomohiro Hayashi, Shigeaki Morita

    Polymer Journal   45 ( 7 )   701 - 710   2013.7

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    DOI: 10.1038/pj.2012.229

  • 血液適合性に優れた高分子材料上でのヒト肺癌細胞の接着と増殖

    二階堂 万葉, 今野 育, 八木 理美, 干場 隆志, 田中 賢

    日本バイオマテリアル学会大会予稿集   シンポジウム2012   281 - 281   2012.11

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  • 動的ナノ界面が生み出すバイオマテリアル機能 培養中のバイオマテリアル界面変化を利用した培養基板の作製

    干場 隆志, 田中 賢, 陳 国平

    日本バイオマテリアル学会大会予稿集   シンポジウム2012   137 - 137   2012.11

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  • Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold Protein adsorption, platelet adhesion, and surface forces Reviewed

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   14 ( 29 )   10196 - 10206   2012.8

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    DOI: 10.1039/c2cp41236e

  • Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold Protein adsorption, platelet adhesion, and surface forces Reviewed

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   14 ( 29 )   10196 - 10206   2012.8

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    DOI: 10.1039/c2cp41236e

  • Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold Protein adsorption, platelet adhesion, and surface forces Reviewed

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   14 ( 29 )   10196 - 10206   2012.8

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    DOI: 10.1039/c2cp41236e

  • Comparison of measurement techniques for the identification of bound water restrained by polymers Reviewed

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    Thermochimica Acta   532   159 - 163   2012.3

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    DOI: 10.1016/j.tca.2011.01.027

  • Comparison of measurement techniques for the identification of bound water restrained by polymers Reviewed

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    THERMOCHIMICA ACTA   532   159 - 163   2012.3

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    DOI: 10.1016/j.tca.2011.01.027

  • Comparison of measurement techniques for the identification of bound water restrained by polymers Reviewed

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    Thermochimica Acta   532   159 - 163   2012.3

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    DOI: 10.1016/j.tca.2011.01.027

  • Comparison of measurement techniques for the identification of bound water restrained by polymers Reviewed

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    Thermochimica Acta   532   159 - 163   2012.3

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    DOI: 10.1016/j.tca.2011.01.027

  • Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure Reviewed

    Macromolecular Rapid Communications   33 ( 4 )   319 - 325   2012.2

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    DOI: 10.1002/marc.201100698

  • 高分子/水界面における凝集構造と生体適合性(バイオテクノロジー,有機エレクトロニクス,界面,一般)

    松野 寿生, 平田 豊章, 田中 賢, 田中 敬二

    電子情報通信学会技術研究報告. OME, 有機エレクトロニクス   111 ( 440 )   37 - 38   2012.2

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    安定かつ平坦なポリ(アクリル酸2-メトキシエチル)(PMEA)表面を,ポリメタクリル酸メチル(PMMA)とブレンドすることで作製した.水中におけるPMEA/PMMAブレンド膜に対する気泡接触角は時間依存的に変化し,水界面近傍における分子鎖凝集構造が再編成されることが分かった.PMEA/PMMAブレンド表面は,従来のPMEA膜と同等以上の血小板粘着抑制能を示し,優れた血液適合性を有することが分かった.

  • Synthesis of Graft Copolymers Based on Poly(2-Methoxyethyl Acrylate) and Investigation of the Associated Water Structure Reviewed

    Irakli Javakhishvili, Masaru Tanaka, Keiko Ogura, Katja Jankova, Soren Hvilsted

    MACROMOLECULAR RAPID COMMUNICATIONS   33 ( 4 )   319 - 325   2012.2

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    DOI: 10.1002/marc.201100698

  • Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure Reviewed

    Macromolecular rapid communications   33 ( 4 )   319 - 325   2012.2

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    DOI: 10.1002/marc.201100698

  • Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure Reviewed

    Macromolecular rapid communications   33 ( 4 )   319 - 325   2012.2

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    DOI: 10.1002/marc.201100698

  • Thermal Characterization of Novel Polymers for Biomedical Applications Reviewed

    Masaru Tanaka

    Netsu Sokutei   151   2012

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  • Thermal Characterization of Novel Polymers for Biomedical Applications Reviewed

    Masaru Tanaka

    Netsu Sokutei   151   2012

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  • Thermal Characterization of Novel Polymers for Biomedical Applications Reviewed

    Masaru Tanaka

    Netsu Sokutei   151   2012

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  • Water structure and polymer dynamics in hydrated blood compatible polymers Reviewed

    Yuko Miwa, Masaru Tanaka, Akira Mochizuki

    Kobunshi Ronbunshu   68 ( 4 )   133 - 146   2011.4

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    DOI: 10.1295/koron.68.133

  • Water structure and polymer dynamics in hydrated blood compatible polymers Reviewed

    Yuko Miwa, Masaru Tanaka, Akira Mochizuki

    KOBUNSHI RONBUNSHU   68 ( 4 )   133 - 146   2011.4

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    DOI: 10.1295/koron.68.133

  • Water structure and polymer dynamics in hydrated blood compatible polymers Reviewed

    Yuko Miwa, Masaru Tanaka, Akira Mochizuki

    KOBUNSHI RONBUNSHU   68 ( 4 )   133 - 146   2011.4

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    DOI: 10.1295/koron.68.133

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior Reviewed

    Masaru Tanaka

    Biochimica et Biophysica Acta - General Subjects   1810 ( 3 )   251 - 258   2011.3

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    DOI: 10.1016/j.bbagen.2010.10.002

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior Reviewed

    Masaru Tanaka

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   1810 ( 3 )   251 - 258   2011.3

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    DOI: 10.1016/j.bbagen.2010.10.002

  • Surface segregation of poly(2-methoxyethyl acrylate) in a mixture with poly(methyl methacrylate) Reviewed

    Toyoaki Hirata, Hisao Matsuno, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   13 ( 11 )   4928 - 4934   2011.3

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    DOI: 10.1039/c0cp02101f

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior Reviewed

    Masaru Tanaka

    Biochimica et Biophysica Acta - General Subjects   1810 ( 3 )   251 - 258   2011.3

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    DOI: 10.1016/j.bbagen.2010.10.002

  • Surface segregation of poly(2-methoxyethyl acrylate) in a mixture with poly(methyl methacrylate) Reviewed

    Toyoaki Hirata, Hisao Matsuno, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   13 ( 11 )   4928 - 4934   2011.3

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    DOI: 10.1039/c0cp02101f

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior Reviewed

    Masaru Tanaka

    Biochimica et Biophysica Acta - General Subjects   1810 ( 3 )   251 - 258   2011.3

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    DOI: 10.1016/j.bbagen.2010.10.002

  • Surface segregation of poly(2-methoxyethyl acrylate) in a mixture with poly(methyl methacrylate) Reviewed

    Toyoaki Hirata, Hisao Matsuno, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   13 ( 11 )   4928 - 4934   2011.3

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    DOI: 10.1039/c0cp02101f

  • 2H-NMR and 13C-NMR study of the hydration behavior of poly(2-methoxyethyl acrylate), poly(2-hydroxyethyl methacrylate) and poly(tetrahydrofurfuryl acrylate) in relation to their blood compatibility as biomaterials Reviewed

    Yuko Miwa, Hiroyuki Ishida, Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1911 - 1924   2010.10

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    DOI: 10.1163/092050610X489682

  • Mechanical effect of acetic acid lignin adsorption on honeycomb-patterned cellulosic films Reviewed

    Yasumitsu Uraki, Chinatsu Matsumoto, Takuro Hirai, Yutaka Tamai, Makiko Enoki, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Journal of Wood Chemistry and Technology   30 ( 4 )   348 - 359   2010.10

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    DOI: 10.1080/02773811003746709

  • Journal of Biomaterials Science, Polymer Edition Preface Reviewed

    Masaru Tanaka, Akira Mochizuki, Hiromi Kitano

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1827 - 1829   2010.10

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    DOI: 10.1163/092050610X527256

  • Hydration structure of poly(2-methoxyethyl acrylate) Comparison with a 2-methoxyethyl acetate model monomer Reviewed

    Shigeaki Morita, Masaru Tanaka, Kuniyuki Kitagawa, Yukihiro Ozaki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1925 - 1935   2010.10

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    DOI: 10.1163/092050610X494613

  • Effect of honeycomb-patterned surface topography on the function of mesenteric adipocytes Reviewed

    Takashige Sato, Masaru Tanaka, Sadaaki Yamamoto, Emiko Ito, Kyoko Shimizu, Yasuyuki Igarashi, Masatsugu Shimomura, Jin Ichi Inokuchi

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1947 - 1956   2010.10

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    DOI: 10.1163/092050610X500615

  • Clarification of the blood compatibility mechanism by controlling the water structure at the blood-poly(meth)acrylate interface Reviewed

    Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1849 - 1863   2010.10

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    DOI: 10.1163/092050610X517220

  • 2H-NMR and 13C-NMR study of the hydration behavior of poly(2-methoxyethyl acrylate), poly(2-hydroxyethyl methacrylate) and poly(tetrahydrofurfuryl acrylate) in relation to their blood compatibility as biomaterials Reviewed

    Yuko Miwa, Hiroyuki Ishida, Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1911 - 1924   2010.10

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    DOI: 10.1163/092050610X489682

  • Thermal properties of freezing bound water restrained by polysaccharides Reviewed

    Tatsuko Hatakeyama, Masaru Tanaka, Hyoe Hatakeyama

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1865 - 1875   2010.10

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    DOI: 10.1163/092050610X486946

  • Study on the water structure and blood compatibility of poly(acryloylmorpholine-r-butyl methacrylate) Reviewed

    Akira Mochizuki, Maki Kimura, Ayano Ina, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1895 - 1910   2010.10

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    DOI: 10.1163/092050610X489321

  • Mechanical effect of acetic acid lignin adsorption on honeycomb-patterned cellulosic films Reviewed

    Yasumitsu Uraki, Chinatsu Matsumoto, Takuro Hirai, Yutaka Tamai, Makiko Enoki, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Journal of Wood Chemistry and Technology   30 ( 4 )   348 - 359   2010.10

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    DOI: 10.1080/02773811003746709

  • Journal of Biomaterials Science, Polymer Edition Preface Reviewed

    Masaru Tanaka, Akira Mochizuki, Hiromi Kitano

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1827 - 1829   2010.10

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    DOI: 10.1163/092050610X527256

  • Hydration structure of poly(2-methoxyethyl acrylate) Comparison with a 2-methoxyethyl acetate model monomer Reviewed

    Shigeaki Morita, Masaru Tanaka, Kuniyuki Kitagawa, Yukihiro Ozaki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1925 - 1935   2010.10

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    DOI: 10.1163/092050610X494613

  • Effect of honeycomb-patterned surface topography on the function of mesenteric adipocytes Reviewed

    Takashige Sato, Masaru Tanaka, Sadaaki Yamamoto, Emiko Ito, Kyoko Shimizu, Yasuyuki Igarashi, Masatsugu Shimomura, Jin Ichi Inokuchi

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1947 - 1956   2010.10

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    DOI: 10.1163/092050610X500615

  • Clarification of the blood compatibility mechanism by controlling the water structure at the blood-poly(meth)acrylate interface Reviewed

    Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1849 - 1863   2010.10

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    DOI: 10.1163/092050610X517220

  • 2H-NMR and 13C-NMR study of the hydration behavior of poly(2-methoxyethyl acrylate), poly(2-hydroxyethyl methacrylate) and poly(tetrahydrofurfuryl acrylate) in relation to their blood compatibility as biomaterials Reviewed

    Yuko Miwa, Hiroyuki Ishida, Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1911 - 1924   2010.10

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    DOI: 10.1163/092050610X489682

  • Thermal properties of freezing bound water restrained by polysaccharides Reviewed

    Tatsuko Hatakeyama, Masaru Tanaka, Hyoe Hatakeyama

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1865 - 1875   2010.10

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    DOI: 10.1163/092050610X486946

  • Study on the water structure and blood compatibility of poly(acryloylmorpholine-r-butyl methacrylate) Reviewed

    Akira Mochizuki, Maki Kimura, Ayano Ina, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1895 - 1910   2010.10

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    DOI: 10.1163/092050610X489321

  • Mechanical effect of acetic acid lignin adsorption on honeycomb-patterned cellulosic films Reviewed

    Yasumitsu Uraki, Chinatsu Matsumoto, Takuro Hirai, Yutaka Tamai, Makiko Enoki, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Journal of Wood Chemistry and Technology   30 ( 4 )   348 - 359   2010.10

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    DOI: 10.1080/02773811003746709

  • Journal of Biomaterials Science, Polymer Edition Preface Reviewed

    Masaru Tanaka, Akira Mochizuki, Hiromi Kitano

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1827 - 1829   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1163/092050610X527256

  • Hydration structure of poly(2-methoxyethyl acrylate) Comparison with a 2-methoxyethyl acetate model monomer Reviewed

    Shigeaki Morita, Masaru Tanaka, Kuniyuki Kitagawa, Yukihiro Ozaki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1925 - 1935   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1163/092050610X494613

  • Effect of honeycomb-patterned surface topography on the function of mesenteric adipocytes Reviewed

    Takashige Sato, Masaru Tanaka, Sadaaki Yamamoto, Emiko Ito, Kyoko Shimizu, Yasuyuki Igarashi, Masatsugu Shimomura, Jin Ichi Inokuchi

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1947 - 1956   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1163/092050610X500615

  • Clarification of the blood compatibility mechanism by controlling the water structure at the blood-poly(meth)acrylate interface Reviewed

    Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1849 - 1863   2010.10

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    DOI: 10.1163/092050610X517220

  • Study on the water structure and blood compatibility of poly(acryloylmorpholine-r-butyl methacrylate) Reviewed

    Akira Mochizuki, Maki Kimura, Ayano Ina, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1895 - 1910   2010.10

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    DOI: 10.1163/092050610X489321

  • Thermal properties of freezing bound water restrained by polysaccharides Reviewed

    Tatsuko Hatakeyama, Masaru Tanaka, Hyoe Hatakeyama

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1865 - 1875   2010.10

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    DOI: 10.1163/092050610X486946

  • Proliferation of periodontal ligament cells on biodegradable honeycomb film scaffold with unified micropore organization Reviewed

    Hiroshi Ishihata, Masaru Tanaka, Nagayoshi Iwama, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    Journal of Biomechanical Science and Engineering   5 ( 3 )   252 - 261   2010.8

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    DOI: 10.1299/jbse.5.252

  • Proliferation of periodontal ligament cells on biodegradable honeycomb film scaffold with unified micropore organization Reviewed

    Hiroshi Ishihata, Masaru Tanaka, Nagayoshi Iwama, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    Journal of Biomechanical Science and Engineering   5 ( 3 )   252 - 261   2010.8

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    DOI: 10.1299/jbse.5.252

  • Proliferation of periodontal ligament cells on biodegradable honeycomb film scaffold with unified micropore organization Reviewed International journal

    Hiroshi Ishihata, Masaru Tanaka, Nagayoshi Iwama, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    Journal of Biomechanical Science and Engineering   5 ( 3 )   252 - 261   2010.7

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    DOI: 10.1299/jbse.5.252

  • Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine) Comparison with polysaccharide-water systems Reviewed

    T. Hatakeyama, M. Tanaka, H. Hatakeyama

    Acta Biomaterialia   6 ( 6 )   2077 - 2082   2010.6

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    DOI: 10.1016/j.actbio.2009.12.018

  • Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine): Comparison with polysaccharide-water systems Reviewed

    T. Hatakeyama, M. Tanaka, H. Hatakeyama

    ACTA BIOMATERIALIA   6 ( 6 )   2077 - 2082   2010.6

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    DOI: 10.1016/j.actbio.2009.12.018

  • Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine) Comparison with polysaccharide-water systems Reviewed

    T. Hatakeyama, Masaru Tanaka, H. Hatakeyama

    Acta Biomaterialia   6 ( 6 )   2077 - 2082   2010.1

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    DOI: 10.1016/j.actbio.2009.12.018

  • Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine) Comparison with polysaccharide-water systems Reviewed

    T. Hatakeyama, Masaru Tanaka, H. Hatakeyama

    Acta Biomaterialia   6 ( 6 )   2077 - 2082   2010.1

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    DOI: 10.1016/j.actbio.2009.12.018

  • Fabrication of novel biocompatible surfaces by two-photon absorption technique using femtosecond laser Reviewed

    Masaru Tanaka, Hirokazu Sato, Yugo Sasaya, Suguru Horinouchi, Jun Ichi Hotta, Yasutaka Matsuo, Kuniharu Ijiro, Keiji Sasaki, Masatsugu Shimomura

    Molecular Crystals and Liquid Crystals   505 ( 1 )   457 - 468   2009.12

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    DOI: 10.1080/15421400902950121

  • Fabrication of novel biocompatible surfaces by two-photon absorption technique using femtosecond laser Reviewed

    Masaru Tanaka, Hirokazu Sato, Yugo Sasaya, Suguru Horinouchi, Jun Ichi Hotta, Yasutaka Matsuo, Kuniharu Ijiro, Keiji Sasaki, Masatsugu Shimomura

    Molecular Crystals and Liquid Crystals   505 ( 1 )   457 - 468   2009.12

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    DOI: 10.1080/15421400902950121

  • Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR Reviewed

    Polymer   50 ( 25 )   6091 - 6099   2009.11

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    DOI: 10.1016/j.polymer.2009.10.037

  • Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of C-13 NMR Reviewed

    Yuko Miwa, Hiroyuki Ishida, Hazime Saito, Masaru Tanaka, Akira Mochizuki

    POLYMER   50 ( 25 )   6091 - 6099   2009.11

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    DOI: 10.1016/j.polymer.2009.10.037

  • Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR Reviewed

    polymer   50 ( 25 )   6091 - 6099   2009.11

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    DOI: 10.1016/j.polymer.2009.10.037

  • Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR Reviewed

    Polymer   50 ( 25 )   6091 - 6099   2009.11

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    DOI: 10.1016/j.polymer.2009.10.037

  • Control of cell fate using self-organized honeycomb-patterned films Reviewed

    Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   2   2009.7

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  • Control of human periodontal ligament cells proliferation on honeycomb-patterned films for regenerative periodontal therapy Reviewed

    Nagayoshi Iwama, Masaru Tanaka, Hiroshi Ishihata, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   2009.7

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  • Control of cell fate using self-organized honeycomb-patterned films Reviewed

    Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   2   2009.7

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  • Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films

    Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

    2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices   390 - 393   2009.7

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  • Control of human periodontal ligament cells proliferation on honeycomb-patterned films for regenerative periodontal therapy Reviewed

    Nagayoshi Iwama, Masaru Tanaka, Hiroshi Ishihata, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   67   2009.7

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  • Control of cell fate using self-organized honeycomb-patterned films Reviewed

    Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   2   2009.7

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  • Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films Reviewed International journal

    Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

    Biodevices   390 - 393   2009.7

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  • Control of human periodontal ligament cells proliferation on honeycomb-patterned films for regenerative periodontal therapy Reviewed

    Nagayoshi Iwama, Masaru Tanaka, Hiroshi Ishihata, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   67   2009.7

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  • Fabrication of ordered arrays of biodegradable polymer pincushions using self-organized honeycomb-patterned films Reviewed

    Masaru Tanaka, Masafumi Takebayashi, Masatsugu Shimomura

    Macromolecular Symposia   279 ( 1 )   175 - 182   2009.5

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    DOI: 10.1002/masy.200950527

  • Fabrication of ordered arrays of biodegradable polymer pincushions using self-organized honeycomb-patterned films Reviewed

    Masaru Tanaka, Masafumi Takebayashi, Masatsugu Shimomura

    Macromolecular Symposia   279 ( 1 )   175 - 182   2009.5

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    DOI: 10.1002/masy.200950527

  • Fabrication of ordered arrays of biodegradable polymer pincushions using self-organized honeycomb-patterned films Reviewed

    Masaru Tanaka, Masafumi Takebayashi, Masatsugu Shimomura

    Macromolecular Symposia   279 ( 1 )   175 - 182   2009.5

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    DOI: 10.1002/masy.200950527

  • Water structure and blood compatibility of poly(tetrahydrofurfuryl acrylate) Reviewed

    Akira Mochizuki, Tatsuko Hatakeyama, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   20 ( 5-6 )   591 - 603   2009.3

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    DOI: 10.1163/156856209X426411

  • Water structure and blood compatibility of poly(tetrahydrofurfuryl acrylate) Reviewed

    Akira Mochizuki, Tatsuko Hatakeyama, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   20 ( 5-6 )   591 - 603   2009.3

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    DOI: 10.1163/156856209X426411

  • Water structure and blood compatibility of poly(tetrahydrofurfuryl acrylate) Reviewed

    Akira Mochizuki, Tatsuko Hatakeyama, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   20 ( 5-6 )   591 - 603   2009.3

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    DOI: 10.1163/156856209X426411

  • Anti-biofouling properties of polymers with a carboxybetaine moiety Reviewed

    Sulumu Tada, Chika Inaba, Kazuya Mizukami, Shigeto Fujishita, Makoto Geminei-Ide, Hiromi Kitano, Akira Mochizuki, Masaru Tanaka, Takayuki Matsunaga

    Macromolecular Bioscience   9 ( 1 )   63 - 70   2009.1

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    DOI: 10.1002/mabi.200800150

  • Anti-Biofouling Properties of Polymers with a Carboxybetaine Moiety Reviewed

    Susumu Tada, Chika Inaba, Kazuya Mizukami, Shigeto Fujishita, Makoto Gemmei-Ide, Hiromi Kitano, Akira Mochizuki, Masaru Tanaka, Takayuki Matsunaga

    MACROMOLECULAR BIOSCIENCE   9 ( 1 )   63 - 70   2009.1

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    DOI: 10.1002/mabi.200800150

  • Tuning of cell proliferation on tough gels by critical charge effect Reviewed

    Mei Chen Yong, Jian Ping Gong, Masaru Tanaka, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Journal of Biomedical Materials Research - Part A   88 ( 1 )   74 - 83   2009.1

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    DOI: 10.1002/jbm.a.31869

  • Comparative study on water structures in PolyHEMA and PolyMEA by XRD-DSC simultaneous measurement Reviewed

    Akira Kishi, Masaru Tanaka, Akira Mochizuki

    Journal of Applied Polymer Science   111 ( 1 )   476 - 481   2009.1

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    DOI: 10.1002/app.29127

  • Anti-biofouling properties of polymers with a carboxybetaine moiety Reviewed

    Sulumu Tada, Chika Inaba, Kazuya Mizukami, Shigeto Fujishita, Makoto Geminei-Ide, Hiromi Kitano, Akira Mochizuki, Masaru Tanaka, Takayuki Matsunaga

    Macromolecular Bioscience   9 ( 1 )   63 - 70   2009.1

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    DOI: 10.1002/mabi.200800150

  • Tuning of cell proliferation on tough gels by critical charge effect Reviewed

    Mei Chen Yong, Jian Ping Gong, Masaru Tanaka, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Journal of Biomedical Materials Research - Part A   88 ( 1 )   74 - 83   2009.1

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    DOI: 10.1002/jbm.a.31869

  • Comparative study on water structures in PolyHEMA and PolyMEA by XRD-DSC simultaneous measurement Reviewed

    Akira Kishi, Masaru Tanaka, Akira Mochizuki

    Journal of Applied Polymer Science   111 ( 1 )   476 - 481   2009.1

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    DOI: 10.1002/app.29127

  • Anti-biofouling properties of polymers with a carboxybetaine moiety Reviewed

    Sulumu Tada, Chika Inaba, Kazuya Mizukami, Shigeto Fujishita, Makoto Geminei-Ide, Hiromi Kitano, Akira Mochizuki, Masaru Tanaka, Takayuki Matsunaga

    Macromolecular Bioscience   9 ( 1 )   63 - 70   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mabi.200800150

  • Tuning of cell proliferation on tough gels by critical charge effect Reviewed

    Mei Chen Yong, Jian Ping Gong, Masaru Tanaka, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Journal of Biomedical Materials Research - Part A   88 ( 1 )   74 - 83   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.a.31869

  • Comparative study on water structures in PolyHEMA and PolyMEA by XRD-DSC simultaneous measurement Reviewed

    Akira Kishi, Masaru Tanaka, Akira Mochizuki

    Journal of Applied Polymer Science   111 ( 1 )   476 - 481   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/app.29127

  • Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films

    Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

    2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices   390 - 393   2009

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  • Fabrication of novel biocompatible surfaces by two-photon absorption technique using femtosecond laser Reviewed

    Masaru Tanaka, Hirokazu Sato, Yugo Sasaya, Suguru Horinouchi, Jun Ichi Hotta, Yasutaka Matsuo, Kuniharu Ijiro, Keiji Sasaki, Masatsugu Shimomura

    Molecular Crystals and Liquid Crystals   505 ( 1 )   219/[457] - 230/[468]   2009

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    DOI: 10.1080/15421400902950121

  • Prevention of postoperative adhesions by a novel honeycomb-patterned poly(lactide) film in a rat experimental model Reviewed

    Yukako Fukuhira, Masaya Ito, Hiroaki Kaneko, Yoshihiko Sumi, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   86 ( 2 )   353 - 359   2008.8

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    DOI: 10.1002/jbm.b.31026

  • Prevention of postoperative adhesions by a novel honeycomb-patterned poly(lactide) film in a rat experimental model Reviewed

    Yukako Fukuhira, Masaya Ito, Hiroaki Kaneko, Yoshihiko Sumi, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   86 ( 2 )   353 - 359   2008.8

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    DOI: 10.1002/jbm.b.31026

  • Prevention of postoperative adhesions by a novel honeycomb-patterned poly(lactide) film in a rat experimental model Reviewed

    Yukako Fukuhira, Masaya Ito, Hiroaki Kaneko, Yoshihiko Sumi, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   86 ( 2 )   353 - 359   2008.8

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    DOI: 10.1002/jbm.b.31026

  • Control of neural stem cell differentiation on honeycomb films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   536 - 540   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.079

  • Formation of hydroxyapatite on a self-organized 3D honeycomb-patterned biodegradable polymer film Reviewed

    Masaru Tanaka, Keiko Yoshizawa, Akinori Tsuruma, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   515 - 519   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.081

  • Enhanced cell survival and yield of rat small hepatocytes by honeycomb-patterned films Reviewed

    Shusaku Tsukiyama, Michiaki Matsushita, Masaru Tanaka, Hitoshi Tamura, Satoru Todo, Sadaaki Yamamoto, Masatsugu Shimomura

    Japanese Journal of Applied Physics   47 ( 2 PART 2 )   1429 - 1434   2008.2

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    DOI: 10.1143/JJAP.47.1429

  • Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes Reviewed

    Keiko Arai, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   530 - 535   2008.2

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    DOI: 10.1016/j.colsurfa.2007.04.128

  • Effect of honeycomb-patterned structure on chondrocyte behavior in vitro Reviewed

    Yukako Fukuhira, Hiroaki Kaneko, Mika Yamaga, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   520 - 525   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.047

  • Control of neural stem cell differentiation on honeycomb films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   536 - 540   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.079

  • Formation of hydroxyapatite on a self-organized 3D honeycomb-patterned biodegradable polymer film Reviewed

    Masaru Tanaka, Keiko Yoshizawa, Akinori Tsuruma, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   515 - 519   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.081

  • Enhanced cell survival and yield of rat small hepatocytes by honeycomb-patterned films Reviewed

    Shusaku Tsukiyama, Michiaki Matsushita, Masaru Tanaka, Hitoshi Tamura, Satoru Todo, Sadaaki Yamamoto, Masatsugu Shimomura

    Japanese Journal of Applied Physics   47 ( 2 PART 2 )   1429 - 1434   2008.2

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    DOI: 10.1143/JJAP.47.1429

  • Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes Reviewed

    Keiko Arai, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   530 - 535   2008.2

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    DOI: 10.1016/j.colsurfa.2007.04.128

  • Effect of honeycomb-patterned structure on chondrocyte behavior in vitro Reviewed

    Yukako Fukuhira, Hiroaki Kaneko, Mika Yamaga, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   520 - 525   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.047

  • Control of neural stem cell differentiation on honeycomb films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   536 - 540   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.079

  • Formation of hydroxyapatite on a self-organized 3D honeycomb-patterned biodegradable polymer film Reviewed

    Masaru Tanaka, Keiko Yoshizawa, Akinori Tsuruma, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   515 - 519   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.081

  • Enhanced cell survival and yield of rat small hepatocytes by honeycomb-patterned films Reviewed

    Shusaku Tsukiyama, Michiaki Matsushita, Masaru Tanaka, Hitoshi Tamura, Satoru Todo, Sadaaki Yamamoto, Masatsugu Shimomura

    Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes   47 ( 2 PART 2 )   1429 - 1434   2008.2

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    DOI: 10.1143/JJAP.47.1429

  • Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes Reviewed

    Keiko Arai, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   530 - 535   2008.2

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    DOI: 10.1016/j.colsurfa.2007.04.128

  • Effect of honeycomb-patterned structure on chondrocyte behavior in vitro Reviewed

    Yukako Fukuhira, Hiroaki Kaneko, Mika Yamaga, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   520 - 525   2008.2

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    DOI: 10.1016/j.colsurfa.2007.05.047

  • Multivariate curve resolution analysis on the multi-component water sorption process into a poly(2-methoxyethyl acrylate) film Reviewed

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Applied Spectroscopy   62 ( 1 )   46 - 50   2008.1

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    DOI: 10.1366/000370208783412555

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy Reviewed

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    MACROMOLECULAR BIOSCIENCE   8 ( 1 )   77 - 85   2008.1

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    DOI: 10.1002/mabi.200700082

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy Reviewed

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    Macromolecular Bioscience   8 ( 1 )   77 - 85   2008.1

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    DOI: 10.1002/mabi.200700082

  • Multivariate curve resolution analysis on the multi-component water sorption process into a poly(2-methoxyethyl acrylate) film Reviewed

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Applied Spectroscopy   62 ( 1 )   46 - 50   2008.1

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    DOI: 10.1366/000370208783412555

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy Reviewed

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    Macromolecular Bioscience   8 ( 1 )   77 - 85   2008.1

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    DOI: 10.1002/mabi.200700082

  • Multivariate curve resolution analysis on the multi-component water sorption process into a poly(2-methoxyethyl acrylate) film Reviewed

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Applied Spectroscopy   62 ( 1 )   46 - 50   2008.1

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    DOI: 10.1366/000370208783412555

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy Reviewed

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    Macromolecular Bioscience   8 ( 1 )   77 - 85   2008.1

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    DOI: 10.1002/mabi.200700082

  • Control of cell proliferation and differentiation using self-organized honeycomb-patterned films

    Masaru Tanaka, Akinori Tsuruma, Yuka Morita, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   4   2254   2008

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  • Microporous "honeycomb" films support enhanced bone formation in vitro

    Mark Birch, Masaru Tanaka, George Kirmizidis, Ito Emiko, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   2   836   2008

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  • Control of cell proliferation and differentiation using self-organized honeycomb-patterned films

    Masaru Tanaka, Akinori Tsuruma, Yuka Morita, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   4   2254   2008

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  • Microporous "honeycomb" films support enhanced bone formation in vitro

    Mark Birch, Masaru Tanaka, George Kirmizidis, Ito Emiko, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   2   836   2008

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  • Control of cell proliferation and differentiation using self-organized honeycomb-patterned films

    Masaru Tanaka, Akinori Tsuruma, Yuka Morita, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   4   2254   2008

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  • Microporous "honeycomb" films support enhanced bone formation in vitro

    Mark Birch, Masaru Tanaka, George Kirmizidis, Ito Emiko, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   2   836   2008

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  • Cold crystallization of poly(ethylene glycol)-water systems Reviewed

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    Thermochimica Acta   465 ( 1-2 )   59 - 66   2007.12

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    DOI: 10.1016/j.tca.2007.09.005

  • Direct observation of interaction between proteins and blood-compatible polymer surfaces Reviewed

    Tomohiro Hayashi, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura, Masahiko Hara

    BIOINTERPHASES   2 ( 4 )   119 - 125   2007.12

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    DOI: 10.1116/1.2794712

  • Cold crystallization of poly(ethylene glycol)-water systems Reviewed

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    THERMOCHIMICA ACTA   465 ( 1-2 )   59 - 66   2007.12

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    DOI: 10.1016/j.tca.2007.09.005

  • Cold crystallization of poly(ethylene glycol)-water systems Reviewed

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    Thermochimica Acta   465 ( 1-2 )   59 - 66   2007.12

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    DOI: 10.1016/j.tca.2007.09.005

  • Cold crystallization of poly(ethylene glycol)-water systems Reviewed

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    Thermochimica Acta   465 ( 1-2 )   59 - 66   2007.12

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    DOI: 10.1016/j.tca.2007.09.005

  • ハニカム構造フィルム上におけるフィブロネクチンの吸着構造と細胞接着

    山本貞明, 田中賢, 角南寛, 新井景子, 高山あい子, 山下滋京子, 森田有香, 下村政嗣

    表面科学講演大会講演要旨集   27th   223   2007.11

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    DOI: 10.14886/sssj.27.0.223.0

  • 原子間力顕微鏡によるハニカム構造フィルム上での血管内皮細胞の初期接着形態観察

    山本貞明, 水谷武臣, 田中賢, 伊藤絵美子, ENIWUMIDE J. O, 森田由香, 角南寛, 居城邦治, 川端和重, 下村政嗣

    表面科学講演大会講演要旨集   27th   152   2007.11

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    DOI: 10.14886/sssj.27.0.152.0

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra Reviewed

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    Applied Spectroscopy   61 ( 8 )   867 - 872   2007.8

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    DOI: 10.1366/000370207781540051

  • 血管内皮細胞の初期伸展に及ぼすハニカムフィルム細孔径の影響 Reviewed

    山本貞明, 田中賢, 伊藤絵美子, 森田有香, 角南寛, 居城邦治, 下村政嗣

    表面科学   28 ( 8 )   433 - 439   2007.8

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    The mechanism that cells use to recognize micro-patterned topographies was clarified. First, 3D double-layer poly (ε-caprolactone) scaffolds equipped with honeycomb-patterned micro-pores ("honeycomb films") were prepared. Then, porcine aortic endothelial cells (PAECs) were cultured on these scaffolds for 1-6 h in serum-free medium. Finally, their initial spreading process was investigated by using AFM and confocal laser scanning microscopy. The attachment and spreading of PAECs on honeycomb films having either 6-or 16-μm pore diameters resulted in voids within the cell cytoplasm, which correspond with the size and location of the honeycomb micropores. The number of cells with this unique morphology decreased with increasing culture time. This dependence of morphology on film pore size and culture time suggests a spreading process of PAECs in which the cells spread trying to sense suitable sites to adhere. Using thick filopodia, the cells spread along the rim of the film and produced pores by close contact between two spreading filopodia. Evidently, these pores became filled in during culture, presumably as the cells began to reorganize their cytoplasma.

    DOI: 10.1380/jsssj.28.433

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy Reviewed

    Takaharu Okajima, Masaru Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumot

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   46 ( 8B )   5552 - 5555   2007.8

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    DOI: 10.1143/JJAP.46.5552

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra Reviewed

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    APPLIED SPECTROSCOPY   61 ( 8 )   867 - 872   2007.8

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    DOI: 10.1366/000370207781540051

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy Reviewed

    Takaharu Okajima, Masara Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumoto

    Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers   46 ( 8 B )   5552 - 5555   2007.8

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    DOI: 10.1143/JJAP.46.5552

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra Reviewed

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    Applied Spectroscopy   61 ( 8 )   867 - 872   2007.8

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    DOI: 10.1366/000370207781540051

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy Reviewed

    Takaharu Okajima, Masaru Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumoto

    Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers   46 ( 8 B )   5552 - 5555   2007.8

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    DOI: 10.1143/JJAP.46.5552

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra Reviewed

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    Applied Spectroscopy   61 ( 8 )   867 - 872   2007.8

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    DOI: 10.1366/000370207781540051

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy Reviewed

    Takaharu Okajima, Masaru Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumoto

    Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes   46 ( 8 B )   5552 - 5555   2007.8

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    DOI: 10.1143/JJAP.46.5552

  • Effect of honeycomb-patterned surface topography on the adhesion and signal transduction of porcine aortic endothelial cells Reviewed

    S. Yamamoto, Masaru Tanaka, H. Sunami, E. Ito, S. Yamashita, Y. Morita, M. Shimomura

    Langmuir   23 ( 15 )   8114 - 8120   2007.7

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    DOI: 10.1021/la7003326

  • Effect of honeycomb-patterned surface topography on the adhesion and signal transduction of porcine aortic endothelial cells Reviewed

    S. Yamamoto, M. Tanaka, H. Sunami, E. Ito, S. Yamashita, Y. Morita, M. Shimomura

    LANGMUIR   23 ( 15 )   8114 - 8120   2007.7

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    DOI: 10.1021/1a7003326

  • Effect of honeycomb-patterned surface topography on the adhesion and signal transduction of porcine aortic endothelial cells Reviewed

    S. Yamamoto, Masaru Tanaka, H. Sunami, E. Ito, S. Yamashita, Y. Morita, M. Shimomura

    Langmuir   23 ( 15 )   8114 - 8120   2007.7

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    DOI: 10.1021/la7003326

  • Relationship between blood compatibility and water structure - Comparative study between 2-methoxyethylacrylate- and 2-methoxyethylmethacrylate-based random copolymers Reviewed

    Etsuko Hirota, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   81 ( 3 )   710 - 719   2007.6

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    DOI: 10.1002/jbm.a.31113

  • Relationship between blood compatibility and water structure - Comparative study between 2-methoxyethylacrylate- and 2-methoxyethylmethacrylate-based random copolymers Reviewed

    Etsuko Hirota, Masaru Tanaka, Akira Mochizuki

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A   81A ( 3 )   710 - 719   2007.6

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    DOI: 10.1002/jbm.a.31113

  • Relationship between blood compatibility and water structure - Comparative study between 2-methoxyethylacrylate- and 2-methoxyethylmethacrylate-based random copolymers Reviewed

    Etsuko Hirota, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   81 ( 3 )   710 - 719   2007.6

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    DOI: 10.1002/jbm.a.31113

  • Honeycomb-like architecture produced by living bacteria, Gluconacetobacter xylinus Reviewed

    Yasumitsu Uraki, Junji Nemoto, Hiroyuki Otsuka, Yutaka Tamai, Junji Sugiyama, Takao Kishimoto, Makoto Ubukata, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Carbohydrate Polymers   69 ( 1 )   1 - 6   2007.5

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    DOI: 10.1016/j.carbpol.2006.08.021

  • Honeycomb-like architecture produced by living bacteria, Gluconacetobacter xylinus Reviewed

    Yasumitsu Uraki, Junji Nemoto, Hiroyuki Otsuka, Yutaka Tamai, Junji Sugiyama, Takao Kishimoto, Makoto Ubukata, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Carbohydrate Polymers   69 ( 1 )   1 - 6   2007.5

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    DOI: 10.1016/j.carbpol.2006.08.021

  • Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds Reviewed

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Biomaterials   28 ( 10 )   1752 - 1760   2007.4

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    DOI: 10.1016/j.biomaterials.2006.12.005

  • Small-diameter porous poly (ε-caprolactone) films enhance adhesion and growth of human cultured epidermal keratinocyte and dermal fibroblast cells Reviewed

    13 ( 4 )   789 - 798   2007.4

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    Autologous keratinocyte grafts provide clinical benefit by rapidly covering wounded areas, but they are fragile. We therefore developed hiocompatihle hexagonal-packed porous films with uniform, circular pore sizes to support human keratinocytes and fibroblasts. Cells were cultured on these porous poly (ε-calprolactone) films with pore sizes ranging from novel ultra-small 3 μm to 20 μm. These were compared with flat (pore-less) films. Cell growth rates, adhesion, migration, and ultrastructural morphology were examined. Human keratinocytes and fibroblasts attached to all films. Furthermore, small-pore (3-5 μm) films showed the highest levels of cell adhesion and survival and prevented migration into the pores and opposing film surface. Keratinocyte migration over small-pore film surface was inhibited. Keratinocytes optimally attached to 3-μm-pore films due to a combination of greater pore numbers (porosity), a greater circumference of the pore edge per unit surface area, and greater frequency of flat surface areas for attachment, allowing better cell-substrate and cell-cell attachment and growth. The 3-μm pore size allowed cell-cell communication, together with diffusion of soluble nutrients and factors from the culture medium or wound substrate. These characteristics are considered important in developing grafts for use in the treatment of human skin wounds.

    DOI: 10.1089/ten.2006.0321

  • Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds Reviewed

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Biomaterials   28 ( 10 )   1752 - 1760   2007.4

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    DOI: 10.1016/j.biomaterials.2006.12.005

  • Small-diameter porous poly (ε-caprolactone) films enhance adhesion and growth of human cultured epidermal keratinocyte and dermal fibroblast cells Reviewed

    13 ( 4 )   789 - 798   2007.4

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    Autologous keratinocyte grafts provide clinical benefit by rapidly covering wounded areas, but they are fragile. We therefore developed hiocompatihle hexagonal-packed porous films with uniform, circular pore sizes to support human keratinocytes and fibroblasts. Cells were cultured on these porous poly (ε-calprolactone) films with pore sizes ranging from novel ultra-small 3 μm to 20 μm. These were compared with flat (pore-less) films. Cell growth rates, adhesion, migration, and ultrastructural morphology were examined. Human keratinocytes and fibroblasts attached to all films. Furthermore, small-pore (3-5 μm) films showed the highest levels of cell adhesion and survival and prevented migration into the pores and opposing film surface. Keratinocyte migration over small-pore film surface was inhibited. Keratinocytes optimally attached to 3-μm-pore films due to a combination of greater pore numbers (porosity), a greater circumference of the pore edge per unit surface area, and greater frequency of flat surface areas for attachment, allowing better cell-substrate and cell-cell attachment and growth. The 3-μm pore size allowed cell-cell communication, together with diffusion of soluble nutrients and factors from the culture medium or wound substrate. These characteristics are considered important in developing grafts for use in the treatment of human skin wounds.

    DOI: 10.1089/ten.2006.0321

  • Effect of pore size of self-organized honeycomb-patterned polymer films on spreading, focal adhesion, proliferation, and function of endothelial cells Reviewed

    Masaru Tanaka, Aiko Takayama, Emiko Ito, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of Nanoscience and Nanotechnology   7 ( 3 )   763 - 772   2007.3

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    DOI: 10.1166/jnn.2007.514

  • Time-resolved in situ ATR-IR observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film Reviewed

    Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Langmuir   23 ( 7 )   3750 - 3761   2007.3

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    DOI: 10.1021/la0625998

  • Effect of pore size of self-organized honeycomb-patterned polymer films on spreading, focal adhesion, proliferation, and function of endothelial cells Reviewed

    Masaru Tanaka, Aiko Takayama, Emiko Ito, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of nanoscience and nanotechnology   7 ( 3 )   763 - 772   2007.3

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    DOI: 10.1166/jnn.2007.514

  • Time-resolved in situ ATR-IR observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film Reviewed

    Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Langmuir   23 ( 7 )   3750 - 3761   2007.3

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    DOI: 10.1021/la0625998

  • Stress relaxation of HepG2 cells measured by atomic force microscopy Reviewed

    T. Okajima, Masaru Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura, H. Tokumoto

    Nanotechnology   18 ( 8 )   2007.2

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    DOI: 10.1088/0957-4484/18/8/084010

  • 18aTC-8 原子間力顕微鏡による生細胞の力学緩和測定(生物物理,領域12,ソフトマター物理,化学物理,生物物理)

    岡嶋 孝治, 田中 賢, 築山 周作, 門脇 翼, 山本 貞明, 下村 政嗣, 徳本 洋志

    日本物理学会講演概要集   62 ( 1 )   325 - 325   2007.2

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  • Effect of Surface Electrostatic Property on Chondrogenic Differentiation of Human Mesenchymal Stem Cells

    Li Guo, Yu Jiang Fan, Naoki Kawazoe, Guo Ping Chen, M. Tanaka, Tetsuya Tateishi, Xing Dong Zhang

    Key Engineering Materials   330-332   1189 - 1192   2007.2

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    DOI: 10.4028/www.scientific.net/kem.330-332.1189

  • Stress relaxation of HepG2 cells measured by atomic force microscopy Reviewed

    T. Okajima, M. Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura, H. Tokumoto

    Nanotechnology   18 ( 8 )   2007.2

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    DOI: 10.1088/0957-4484/18/8/084010

  • Suppression of neural stem cell differentiation by Honeycomb-patterned films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Sada Aki Yamamoto, Masatsugu Shimomura

    10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 IFMBE Proceedings   14 ( 1 )   3558 - 3561   2007.1

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  • Suppression of neural stem cell differentiation by Honeycomb-patterned films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Sada Aki Yamamoto, Masatsugu Shimomura

    10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 IFMBE Proceedings   14 ( 1 )   3558 - 3561   2007.1

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  • Direct observation of biocompatibility of PMEA(poly(2-methoxyethyl acrylate)) using Atomic Force Microscop Reviewed

    Tomohiro Hayashi, Masaru Tanaka

    Biointerphases   2   119   2007

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  • The influence of pore size of a honeycomb film on early spreading process of endtherial cells Reviewed

    Sadaaki Yamamoto, Masaru Tanaka

    J. Surf. Sci. Soc. Jap   28 ( 8 )   433   2007

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  • Direct observation of biocompatibility of PMEA(poly(2-methoxyethyl acrylate)) using Atomic Force Microscop Reviewed

    Tomohiro Hayashi, Masaru Tanaka

    Biointerphases   2   119   2007

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  • The influence of pore size of a honeycomb film on early spreading process of endtherial cells Reviewed

    Sadaaki Yamamoto, Masaru Tanaka

    J. Surf. Sci. Soc. Jap   28 ( 8 )   433   2007

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  • Study on structure of water in membranes of PMEA and PHEMA by 2H-NMR

    Hiroyuki Ishida, Yuko Miwa, Akira Mochizuki, Masaru Tanaka

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4375 - 4376   2006.12

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  • Study on structure of water in PMEA and PHEMA and there copolymers by 2H solid-state NMR

    Yuko Miwa, Hiroyuki Ishida, Akira Mochizuki, Masaru Tanaka

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   2006.10

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  • Relationship between adsorbed fibronectin and cell adhesion on a honeycomb-patterned film Reviewed

    Sadaaki Yamamoto, Masaru Tanaka, Hiroshi Sunami, Keiko Arai, Aiko Takayama, Shigeko Yamashita, Yuka Morita, Masatsugu Shimomura

    Surface Science   600 ( 18 )   3785 - 3791   2006.9

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    DOI: 10.1016/j.susc.2006.01.085

  • Relationship between adsorbed fibronectin and cell adhesion on a honeycomb-patterned film Reviewed

    Sadaaki Yamamoto, Masaru Tanaka, Hiroshi Sunami, Keiko Arai, Aiko Takayama, Shigeko Yamashita, Yuka Morita, Masatsugu Shimomura

    Surface Science   600 ( 18 )   3785 - 3791   2006.9

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    DOI: 10.1016/j.susc.2006.01.085

  • Control of hepatocyte adhesion and function on self-organized honeycomb-patterned polymer film Reviewed

    Masaru Tanaka, Kazutaka Nishikawa, Hisashi Okubo, Hirofumi Kamachi, Tomoaki Kawai, Michiaki Matsushita, Satoru Todo, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   464 - 469   2006.8

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    DOI: 10.1016/j.colsurfa.2005.11.098

  • Topographical control of neurite extension on stripe-patterned polymer films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Nobuyuki Fukushima, Hiroshi Yabu, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   470 - 474   2006.8

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    DOI: 10.1016/j.colsurfa.2005.11.100

  • Effect of honeycomb film on protein adsorption, cell adhesion and proliferation Reviewed

    Hiroshi Sunami, Emiko Ito, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   548 - 551   2006.8

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    DOI: 10.1016/j.colsurfa.2005.11.041

  • Control of hepatocyte adhesion and function on self-organized honeycomb-patterned polymer film Reviewed

    Masaru Tanaka, Kazutaka Nishikawa, Hisashi Okubo, Hirofumi Kamachi, Tomoaki Kawai, Michiaki Matsushita, Satoru Todo, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   464 - 469   2006.8

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    DOI: 10.1016/j.colsurfa.2005.11.098

  • Topographical control of neurite extension on stripe-patterned polymer films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Nobuyuki Fukushima, Hiroshi Yabu, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   470 - 474   2006.8

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    DOI: 10.1016/j.colsurfa.2005.11.100

  • Effect of honeycomb film on protein adsorption, cell adhesion and proliferation Reviewed

    Hiroshi Sunami, Emiko Ito, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   548 - 551   2006.8

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    DOI: 10.1016/j.colsurfa.2005.11.041

  • Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoylphosphatidylethanolamine Reviewed

    Yukako Fukuhira, Eiichi Kitazono, Takami Hayashi, Hiroaki Kaneko, Masaru Tanaka, Masatsugu Shimomura, Yoshihiko Sumi

    Biomaterials   27 ( 9 )   1797 - 1802   2006.3

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    DOI: 10.1016/j.biomaterials.2005.10.019

  • Study on blood compatibility with poly(2-methoxyethylacrylate)-relationship between surface structure., water structure, and platelet compatibility in 2-methoxyethylacrylate/2hydroxyethylmethacrylate diblock copolymer Reviewed

    E Hirota, K Ute, M Uehara, T Kitayama, M Tanaka, A Mochizuki

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A   76A ( 3 )   540 - 550   2006.3

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    DOI: 10.1002/jbm.a.30563

  • Study on blood compatibility with poly(2-methoxyethylacrylate) - Relationship between surface structure, water structure, and platelet compatibility in 2-methoxyethylacrylate/2-hydroxyethylmethacrylate diblock copolymer Reviewed

    Etsuko Hirota, Koichi Ute, Mitsunari Uehara, Tatsuki Kitayama, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   76 ( 3 )   540 - 550   2006.3

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    DOI: 10.1002/jbm.a.30563

  • Study on blood compatibility with poly(2-methoxyethylacrylate) - Relationship between surface structure, water structure, and platelet compatibility in 2-methoxyethylacrylate/2-hydroxyethylmethacrylate diblock copolymer Reviewed

    Etsuko Hirota, Koichi Ute, Mitsunari Uehara, Tatsuki Kitayama, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   76 ( 3 )   540 - 550   2006.3

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    DOI: 10.1002/jbm.a.30563

  • Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoylphosphatidylethanolamine Reviewed

    Yukako Fukuhira, Eiichi Kitazono, Takami Hayashi, Hiroaki Kaneko, Masaru Tanaka, Masatsugu Shimomura, Yoshihiko Sumi

    Biomaterials   27 ( 9 )   1797 - 1802   2006.3

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    DOI: 10.1016/j.biomaterials.2005.10.019

  • Study on blood compatibility with poly(2-methoxyethylacrylate) - Relationship between surface structure, water structure, and platelet compatibility in 2-methoxyethylacrylate/2-hydroxyethylmethacrylate diblock copolymer Reviewed

    Etsuko Hirota, Koichi Ute, Mitsunari Uehara, Tatsuki Kitayama, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   76 ( 3 )   540 - 550   2006.3

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    DOI: 10.1002/jbm.a.30563

  • Adhesion and signal transduction of endothelial cells on a honeycomb films pre-coated by fibronectin

    Sadaaki Yamamot, Masaru Tanaka, Hiroshi Sunami, Yuka Mortta, Emio Ito, Keiko Arai, Shigeko Yamashita, Masatsugu Shimomura

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   5493 - 5494   2006

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  • Surface properties of endothelial cells cultured on hydrogels

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Yasuda Kazunori, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4860   2006

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  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [24] ATR-IR studied of protein adsorption onto biocompatible polymer

    Shoji Deguchi, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4379 - 4380   2006

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  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [23] multivariate analysis of time-resolved IR spectra upon water sorption into PMEA film

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4377 - 4378   2006

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  • Relationship between adsorbed fibronectin and FAK activation on a honeycomb-patterned film Reviewed

    Masaru Tanaka

    J. Surf. Sci. Soc. Jap   27 ( 10 )   2006

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  • Measurement of ice crystal formation in biocompatible polymer by XRD-DSC

    Akira Kishi, Masaru Tanaka, Akira Mochizuki

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   2139   2006

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  • Growth inhibition of cancer cells on honeycomb films

    Chiho Asahi, Masaru Tanaka, Jun Ichi Hamada, Yoshihide Toyokawa, Emiko Ito, Sadaaki Yamamoto, Masatsugu Shimomura

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1918   2006

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  • Control of cytoskeletone structure by using 3D microporus film

    Hiroshi Sunami, Emiko Ito, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   5422 - 5423   2006

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  • Biomedical application of patterned polymer films prepared by self-organization Reviewed

    Masaru Tanaka, Masatsugu Shimomura

    J. Surf. Sci. Soc. Jap   27   170   2006

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  • Time-resolved IR observations of molecular sorption to a polymer film from a solution

    Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4278 - 4279   2006

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  • Surface properties of endothelial cells cultured on hydrogels

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Yasuda Kazunori, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4860   2006

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  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [15] hydration structures of a PMEA film contacting with water

    Shieeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1939   2006

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  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [17] sorption of small molecules

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1135   2006

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  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [24] ATR-IR studied of protein adsorption onto biocompatible polymer

    Shoji Deguchi, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4379 - 4380   2006

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  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [23] multivariate analysis of time-resolved IR spectra upon water sorption into PMEA film

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4377 - 4378   2006

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  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [16] protein adsorption onto different polymer films

    Shoji Deguchi, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1940   2006

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  • Relationship between adsorbed fibronectin and FAK activation on a honeycomb-patterned film Reviewed

    Masaru Tanaka

    J. Surf. Sci. Soc. Jap   27 ( 10 )   2006

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  • Regulation of neural stem cell differentiation and proliferation by self-organized honeycomb-patterned films

    Akinori Tsuruma, Masaru Tanaka, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1911   2006

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  • Regulation of Neural stem cell differentiation, proliferation and forming of neural networks by changing pore size of self-organized honeycomb films

    Akinori Tsuruma, Masaru Tanaka, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   5393 - 5394   2006

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  • Novel nano- And micro- fabrication technique of polymer materials based on self-organization

    Masatsugu Shimomura, Hiroshi Yabu, Masaru Tanaka

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   100 - 102   2006

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  • Nano-dynamics of living cell surface by AFM

    Takaharu Okajima, Masaru Tanaka, Shusaku Tsukiyama, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumoto

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   2109   2006

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  • Measurement of ice crystal formation in biocompatible polymer by XRD-DSC

    Akira Kishi, Masaru Tanaka, Akira Mochizuki

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   2139   2006

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  • Growth inhibition of cancer cells on honeycomb films

    Chiho Asahi, Masaru Tanaka, Jun Ichi Hamada, Yoshihide Toyokawa, Emiko Ito, Sadaaki Yamamoto, Masatsugu Shimomura

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1918   2006

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  • Growth and motility of human cancer cells on honeycomb films

    Chiho Asahi, Masaru Tanaka, Jun Ichi Hamada, Yoshihide Toyokawa, Emiko Ito, Haruka Maeda, Sadaaki Yamamoto, Masatsugu Shimomura

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   5491 - 5492   2006

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  • Formation of hydroxyapatite on honeycomb films

    Keiko Yoshizawa, Masaru Tanaka, Akinori Tsuruma, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1929   2006

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  • Control of the protein adsorption on honeycomb film by changing the pore size of honeycomb films

    Hiroshi Sunami, Masaru Tanaka, Sadaaki Yamamoto, Emiko Ito, Masatsugu Shimomura

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1973   2006

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  • Control of cytoskeletone structure by using 3D microporus film

    Hiroshi Sunami, Emiko Ito, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   5422 - 5423   2006

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  • Comparative study on blood compatibility of poly(MEA-HEMA) and poly(MEMA-HEMA)

    Yusuke Nishimori, Akira Mochizuki, Masaru Tanaka

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   2017   2006

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  • Biomedical application of patterned polymer films prepared by self-organization Reviewed

    Masaru Tanaka, Masatsugu Shimomura

    J. Surf. Sci. Soc. Jap   27   170   2006

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  • Correlation between the structure of water in the vicinity of carboxybetaine polymers and their blood-compatibility Reviewed

    Hiromi Kitano, Susumu Tada, Takayuki Mori, Kohei Takaha, Makoto Gemmei-Ide, Masaru Tanaka, Mitsuhiro Fukuda, Yoshiyuki Yokoyama

    Langmuir   21 ( 25 )   11932 - 11940   2005.12

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    DOI: 10.1021/la0515571

  • Correlation between the structure of water in the vicinity of carboxybetaine polymers and their blood-compatibility Reviewed

    H Kitano, S Tada, T Mori, K Takaha, M Gemmei-Ide, M Tanaka, M Fukuda, Y Yokoyama

    LANGMUIR   21 ( 25 )   11932 - 11940   2005.12

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    DOI: 10.1021/la0515571

  • Correlation between the structure of water in the vicinity of carboxybetaine polymers and their blood-compatibility Reviewed

    Hiromi Kitano, Susumu Tada, Takayuki Mori, Kohei Takaha, Makoto Gemmei-Ide, Masaru Tanaka, Mitsuhiro Fukuda, Yoshiyuki Yokoyama

    Langmuir   21 ( 25 )   11932 - 11940   2005.12

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    DOI: 10.1021/la0515571

  • Production of mesoscopically patterned cellulose film Reviewed

    Junji Nemoto, Yasumitsu Uraki, Takao Kishimoto, Yuzo Sano, Ryo Funada, Noriaki Obata, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Bioresource Technology   96 ( 17 )   1955 - 1958   2005.11

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    DOI: 10.1016/j.biortech.2005.01.034

  • Production of mesoscopically patterned cellulose film Reviewed

    Junji Nemoto, Yasumitsu Uraki, Takao Kishimoto, Yuzo Sano, Ryo Funada, Noriaki Obata, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Bioresource Technology   96 ( 17 )   1955 - 1958   2005.11

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    DOI: 10.1016/j.biortech.2005.01.034

  • Morphological changes in neurons by self-organized patterned films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Nobuyuki Fukushima, Masatsugu Shimomura

    e-Journal of Surface Science and Nanotechnology   3   2005.5

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    DOI: 10.1380/ejssnt.2005.159

  • Morphological changes in neurons by self-organized patterned films Reviewed

    Akinori Tsuruma, Masaru Tanaka, Nobuyuki Fukushima, Masatsugu Shimomura

    e-Journal of Surface Science and Nanotechnology   3   2005.5

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    DOI: 10.1380/ejssnt.2005.159

  • Structure of water incorporated in sulfobetaine polymer films as studied by ATR-FTIR Reviewed

    Hiromi Kitano, Takayuki Mori, Yuki Takeuchi, Susumu Tada, Makoto Gemmei-Ide, Yoshiyuki Yokoyama, Masaru Tanaka

    Macromolecular Bioscience   5 ( 4 )   314 - 321   2005.4

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    DOI: 10.1002/mabi.200400212

  • Superhydrophobic and lipophobic properties of self-organized honeycomb and pincushion structures Reviewed

    Hiroshi Yabu, Masafumi Takebayashi, Masaru Tanaka, Masatsugu Shimomura

    Langmuir   21 ( 8 )   3235 - 3237   2005.4

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    DOI: 10.1021/la050013w

  • Structure of water incorporated in sulfobetaine polymer films as studied by ATR-FTIR Reviewed

    Hiromi Kitano, Takayuki Mori, Yuki Takeuchi, Susumu Tada, Makoto Gemmei-Ide, Yoshiyuki Yokoyama, Masaru Tanaka

    Macromolecular Bioscience   5 ( 4 )   314 - 321   2005.4

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    DOI: 10.1002/mabi.200400212

  • Superhydrophobic and lipophobic properties of self-organized honeycomb and pincushion structures Reviewed

    Hiroshi Yabu, Masafumi Takebayashi, Masaru Tanaka, Masatsugu Shimomura

    Langmuir   21 ( 8 )   3235 - 3237   2005.4

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    DOI: 10.1021/la050013w

  • Fabrication of novel biodegradable particles and application for DDS by self-organized precipitation method

    Daisuke Ohsato, Takeshi Higuchi, Hiroshi Yabu, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    54th SPSJ Symposium on Macromolecules 54th SPSJ Symposium on Macromolecules - Polymer Preprints, Japan   54   4949 - 4950   2005

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