CHO IKSUNG
Organization
Institute for Materials Chemistry and Engineering Department of Soft Materials Chemistry Assistant Professor
Graduate School of Engineering
（Concurrent）
Title
Assistant Professor
Contact information
Tel
08098625822
Profile
Earlier in my graduate training, under the supervision of Prof. Kang Moo Huh, I learned how to develop hydrogels for drug delivery and the treatment of degenerative diseases. This experience solidified my intention to pursue a career in biomaterial design. To further this aim, I pursued a Ph.D. under the guidance of Prof. Tooru Ooya. In this program, I acquired skills in the molecular design of advanced materials, the organic synthesis of biocompatible compounds, and the characterization of biomaterials' physical properties. Additionally, I have three years of experience as a postdoctoral fellow at the University of Illinois at Chicago, working in Prof. Jae-Won Shin’s group. Since joining Dr. Shin’s group, I have been learning new skills to improve mesenchymal stromal cell (MSC)-based therapeutics through biomaterial design in the context of tissue regeneration and fibrosis. Currently, at Kyushu University, I am engaged in a study to investigate how a novel biomaterial affects stem cell behavior, particularly regarding morphology and differentiation. The study aims to explore how the intermediate water can be regulated by the biomaterial while maintaining other factors such as elastic modulus and surface topology. This research has potential applications in fields such as tissue engineering, regenerative medicine, and drug discovery.
External link
Degree
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Ph.D degree
Research History
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University of Illinois at Chicago (Postdoctoral Researcher)
Research Interests・Research Keywords
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Research theme：Tough, self-healable PMEA based hydrogel with enhanced blood-compatibility
Keyword：PMEA, Self-healing, Mechanical properties, Hydrogel
Research period： 2024.4 - 2025.3
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Research theme：Enhancing Blood Compatibility of Chitosan Derivatives, Investigating the Role of Water State
Keyword：Chitosan, Blood compatibility, Water state
Research period： 2023.5 - 2024.12
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Research theme：Developing hydrogels with advanced functionalities for tissue regeneration
Keyword：Hydrogel, Stiffness
Research period： 2023.1 - 2025.1
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Research theme：Developing a new strategy for how novel biomaterials affect single stem cell behavior
Keyword：Single-cell Encapsulation, Water molecule, Poly(2-Methoxyethyl Acrylate)
Research period： 2023.1 - 2025.1
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Research theme：Encapsulate single cell using engineered biomaterial to increase the retention time at target site and improve treatment of fibrosis.
Keyword：Lung fibrosis, Single-cell encapsulation
Research period： 2020.6 - 2022.12
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Research theme：Introduce symmetric breaking micro-environment around single cell and determine how the polarized environment in single-cell level direct stem cell differentiation
Keyword：Stem cell differentiation, Symmetric breaking, Single-cell encapsulation
Research period： 2020.2 - 2022.8
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Research theme：Polyrotaxane-based self-healing hydrogel with high mechanical stiffness excellent biocompatibility
Keyword：Polyrotaxane-based hydrogel, Tough hydrogel, Self-healing hydrogel, Biocompatibility
Research period： 2018.3 - 2020.2
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Research theme：Tuned cell attachments by double-network hydrogels bearing robust and self-healing properties
Keyword：Cell attachment, Double-network hydrogel, Self-healing properties
Research period： 2018.1 - 2018.11
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Research theme：A supramolecular hydrogel based on polyglycerol dendrimer-specific amino group recognition
Keyword：Stimuli responsive polymer, Polyglycerol dendrimer
Research period： 2017.10 - 2018.3
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Research theme：Synthesis and characterization of injectable self-healing hydrogel
Keyword：Injectable hydrogel, Self-healing polymer
Research period： 2017.3 - 2017.10
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Research theme：Synthesis and characterization of in situ crosslinkable glycol chitosan-based thermogels.
Keyword：Dual crosslinkable polymer, Michael type addition reaction, Thermogelling polymer
Research period： 2014.7 - 2016.8
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Research theme：Preparation and evaluation of ocular drug delivery system using thermo-sensitive hexanoyl glycol chitosan.
Keyword：Ocular delivery, Thermogelling polymer, Drug delivery
Research period： 2014.7 - 2015.7
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Research theme：Synthesis and evaluation of mucoadhesive thermo-gelling polymers.
Keyword：Mucoadhesive polymer, Thermogelling polymer, Thiolated polymers
Research period： 2014.6 - 2016.8
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Research theme：Preparation of photo-crosslinkable glycol chitosan-based thermogels
Keyword：Photo-crosslinkable hydrogel, Thermogelling polymer
Research period： 2013.8 - 2015.3
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Research theme：Synthesis and characterization of hexanoyl glycol chitosan as a thermogelling polymer.
Keyword：Hydrogel, Thermogelling polymer, Glycol chitosan
Research period： 2013.6 - 2013.8
Awards
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Best student poster award
2018.8 14th international chitin and chitosan conference
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Bajpai-Saha award
2017.10 6th Asian biomaterial congress
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Best paper award
2016.6 Korean society for biomaterials
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Best paper award
2014.6 the 27th international symposium on chemical engineering
Papers
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Injectable Poloxamer Hydrogel Formulations for Intratympanic Delivery of Dexamethasone Reviewed International journal
@Le, Thi Phuc; @Yu, Yang; @Cho, Ik Sung; @Suh, Eun Yeong; @Kwon, Hyuk Chan; @Shin, Sun-Ae; @Park, Yong-Ho; @Huh, Kang Moo
JOURNAL OF KOREAN MEDICAL SCIENCE 38 ( 17 ) 2023.4
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Deterministic Single Cell Encapsulation in Asymmetric Microenvironments to Direct Cell Polarity Reviewed International journal
@Cho, Ik Sung; @Gupta, Prerak; @Mostafazadeh, Nima; @Wong, Sing Wan; @Saichellappa, Saiumamaheswari; @Lenzini, Stephen; @Peng, Zhangli; @Shin, Jae-Won
ADVANCED SCIENCE 10 ( 3 ) 2023.1
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Protein corona formation on epigallocatechin gallate-Au nanoparticles suppressed tumor accumulation Reviewed International journal
@Chihiro Wakayama, @Sachiko @Inubushi, Tomonari Kunihisa, @Sachiko Mizumoto, @Motoi Baba, @Hirokazu Tanino, @Ik Sung Cho, @Tooru Ooya
JCIS Open 2023.1
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Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues Reviewed International journal
@Wong, Sing Wan; @Tamatam, Chandramohan R.; @Cho, Ik Sung; @Toth, Peter T.; @Bargi, Raymond; @Belvitch, Patrick; @Lee, James C.; @Rehman, Jalees; @Reddy, Sekhar P.; @Shin, Jae-Won
NATURE BIOMEDICAL ENGINEERING 6 ( 1 ) 54 - + 2022.1
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Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells Reviewed International journal
@Lenzini, Stephen; @Debnath, Koushik; @Joshi, Jagdish C.; @Wong, Sing Wan; @Srivastava, Kriti; @Geng, Xue; @Cho, Ik Sung; @Song, Angela; @Bargi, Raymond; @Lee, James C.; @Mo, Gary C. H.; @Mehta, Dolly; @Shin, Jae-Won
ACS NANO 15 ( 11 ) 17439 - 17452 2021.11
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Preparation and characterization of an in situ crosslinkable glycol chitosan thermogel for biomedical applications Reviewed International journal
@Oh, Hye Min; @Kang, Eunae; @Li, Zhengzheng; @Cho, K. Sung; @Kim, Da Eun; @Mallick, Sudipta; @Kang, Sun-Woong; @Roh, Kyung-Ho; @Huh, Kang Moo
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY 80 820 - 828 2019.12
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Cell‐Encapsulating Hydrogel Puzzle: Polyrotaxane‐Based Self‐Healing Hydrogels Reviewed International journal
Chemistry–A European Journal 2019.11
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Tuned cell attachments by double-network hydrogels consisting of glycol chitosan, carboxylmethyl cellulose and agar bearing robust and self-healing properties Reviewed International journal
@I.S. Cho, @T. Ooya
International Journal of Biological Macromolecules 2019.8
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Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer Reviewed International journal
@I.S. Cho, @H.M. Oh, @M.O. Cho, @B.S Jang, @J.K. Cho, @K.H. Park, @S. W. Kang, @K.M. huh
Biomaterials research 2018.9
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A Supramolecular Hydrogel Based on Polyglycerol Dendrimer‐Specific Amino Group Recognition Reviewed International journal
Chemistry–An Asian Journal 2018.7
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Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease Reviewed International journal
@Li, Zhengzheng; @Shim, Hyeeun; @Cho, Myeong Ok; @Cho, Ik Sung; @Lee, Jin Hyun; @Kang, Sun-Woong; @Kwon, Bosun; @Huh, Kang Moo
CARBOHYDRATE POLYMERS 184 342 - 353 2018.3
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An injectable and self-healing hydrogel for spatiotemporal protein release via fragmentation after passing through needles Reviewed International journal
@I.S. Cho, @T. Ooya
Journal of biomaterials science, polymer Edition 2018.1
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Bioinspired tuning of glycol chitosan for 3D cell culture Reviewed International journal
@Cho, Myeong Ok; @Li, Zhengzheng; @Shim, Hye-Eun; @Cho, Ik-Sung; @Nurunnabi, Md; @Park, Honghyun; @Lee, Kuen Yong; @Moon, Sung-Hwan; @Kim, Ki-Suk; @Kang, Sun-Woong; @Huh, Kang Moo
NPG ASIA MATERIALS 8 2016.9
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Thermosensitive hexanoyl glycol chitosan-based ocular delivery system for glaucoma therapy Reviewed International journal
@Cho, Ik Sung; @Park, Chun Gwon; @Huh, Beom Kang; @Cho, Myeong Ok; @Khatun, Zehedina; @Li, Zhengzheng; @Kang, Sun-Woong; @Bin Choy, Young; @Huh, Kang Moo
ACTA BIOMATERIALIA 39 124 - 132 2016.7
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Synthesis and characterization of a new photo-crosslinkable glycol chitosan thermogel for biomedical applications Reviewed International journal
@Cho, Ik Sung; @Cho, Myeong Ok; @Li, Zhengzheng; @Nurunnabi, Md; @Park, Sung Young; @Kang, Sun-Woong; @Huh, Kang Moo
CARBOHYDRATE POLYMERS 144 59 - 67 2016.6
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Synthesis of N-Acetylated Glycol Chitosans and Their Thermo-sensitive Sol-Gel Transition Properties Reviewed
@You, Ho Seon; @Cho, Myeong Ok; @Cho, Ik Sung; @Li, Zhengzheng; @Kim, Nam-Hong; @Jang, Mi-Kyeong; @Kang, Sun-Woong; @Huh, Kang Moo
POLYMER-KOREA 40 ( 2 ) 328 - 335 2016.3
Presentations
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Deterministic symmetry breaking of single cells in three-dimensional matrices
@Ik Sung Cho, @Jae-Won Shin
Gordon Research Seminar 2022.7
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Matrix-mediated symmetry breaking of single cells in a three-dimensional space
@Ik Sung Cho, @Jae-Won Shin
American Society For Biomaterial 2022.4
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Matrix-mediated symmetry breaking of single cells in a three-dimensional space
@Ik Sung Cho, @Jae-Won Shin
American Physical Society 2022.3
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Engineering single cell polarity in three-dimensional matrices
@Ik Sung Cho, @Jae-Won Shin
American Society For Biomaterial 2021.4
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Cell encapsulation and proliferation in polyrotaxane-based self-healing hydrogel
@Ik Sung Cho, @Tooru Ooya
36th Cyclodextrin Symposium 2019.9
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Extremely Soft Biocompatible Polysaccharide-based Self-healing Slide-ring Hydrogel International conference
@Ik Sung Cho, @Tooru Ooya
International Congress on Pure & Applied Chemistry 2019.8
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Polyrotaxane-based self-healing hydrogel for the tissue engineering
@Ik Sung Cho, @Tooru Ooya
The Society of Polymer Science 2019.5
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Injectable and Self-healing Carbohydrate-based Hydrogel for Protein Delivery International conference
@Ik Sung Cho, @Tooru Ooya
6th Asian biomaterial congress 2017.10
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Synthesis and characterization of photo-crosslinkable thermogelling hexanoyl glycol chitosan International conference
@Ik Sung Cho, @Kang Moo Huh
The 27th international symposium on chemical engineering 2014.12
MISC
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Mucoadhesive polymer for M-cell targeting as oral vaccine delivery vehicle Reviewed
@ Ik Sung Cho
Woodhead Publishing Series in Biomaterials 2021.12
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Supramolecular Self-Healing Gels Reviewed
@Ik Sung Cho, @Tooru Ooya
CRC Press 2021.12
Industrial property rights
| Patent | Number of applications: 0 | Number of registrations: 0 |
| Utility model | Number of applications: 0 | Number of registrations: 0 |
| Design | Number of applications: 0 | Number of registrations: 0 |
| Trademark | Number of applications: 0 | Number of registrations: 0 |
Professional Memberships
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American society of biomaterials
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American Physical society
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American Heart association
Research Projects
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The study investigates the prevention of fibrotic injury by delivery of MSCs. To improve the efficacy of the MSCs, the proposal seeks to increase their residence time by coating with the cells with an alginate hydrogel designed to prevent clearance by macrophages. The preliminary work demonstrates macrophage clearance and some improvement in retention with Aim 1 further modifying the gel to increase retention. Aim 2 will the evaluate the efficacy of the coated MSCs with a specific focus on determining if the cells prevent vascular hyperpermeability and thus fibrosis.
2022 - 2023
Japan Society for the Promotion of Science Postdoctoral Fellowships for Research Abroad
Authorship：Principal investigator Grant type：Joint research
Outline of Social Contribution and International Cooperation activities
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My academic journey, spanning Korea, Japan, and the United States, has afforded me a unique perspective in fostering social contributions and international collaborations. In this essay, I'll detail how my educational and research experiences across these diverse cultures have deepened my understanding of social dynamics, broadened my global outlook, and equipped me with the skills necessary for significant contributions to social and international projects. Throughout my journey, I've built a vast network of colleagues, mentors, and collaborators in these countries, creating a wealth of opportunities for partnerships aimed at addressing societal challenges. By leveraging these connections, I am able to unite experts from various fields, institutions, and nations to tackle complex issues. The varied perspectives and expertise in my network encourage cross-cultural exchanges, share best practices, and foster the development of innovative solutions, amplifying our collective impact.