Faculty Profiles - yamauchi takuji

Information

写真a

yamauchi takuji

Organization

Kyushu University Hospital Hematology, Oncology & Cardiovascular medicine Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）

Contact information

Tel

0926425230

Degree

M.D., Ph.D.

Research Interests・Research Keywords

Research theme：Identification of novel therapeutic targets for AML therapy

Keyword：acute myeloid leukemia

Research period： 2018.4

Awards

日本血液学会奨励賞

2018.10

Papers

Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by the DCPS decapping enzyme Reviewed International journal

Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al-Raqad, Manami Maeda, Vivien A. C. Schoonenberg, Mitchel A. Cole, Claudio Macias Trevino, Yuichi Ishikawa, Qiuming Yao, Michitaka Nakano, Fumio Arai, Stuart H. Orkin, Bruno Reversade, Silvia Buonamici, Luca Pinello, Koichi Akashi, Daniel E. Bauer and Takahiro Maeda

Cancer Cell 2018.3

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Language：English Publishing type：Research paper (scientific journal)
Immune-checkpoint profiles for T cells in bronchoalveolar lavage fluid of patients with immune-checkpoint inhibitor-related interstitial lung disease. Int Immunol. Reviewed International journal

Suzuki K, Yanagihara T, Matsumoto K, Kusaba H, Yamauchi T, Ikematsu Y, Tanaka K, Otsubo K, Inoue H, Yoneshima Y, Iwama E, Arimura-Omori M, Harada E, Hamada N, Okamoto I, Nakanishi Y.

Int Immunol. 28 ( 32(8) ) 547 - 557 2020.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/intimm/dxaa022.
A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells Reviewed International journal

Fumiaki Jinnouchi, Takuji Yamauchi, Ayano Yurino, Takuya Nunomura, Michitaka Nakano, Chika Iwamoto, Teppei Obara, Kohta Miyawaki, Yoshikane Kikushige, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Eishi Baba, Koichi Akashi, Katsuto Takenaka

Blood 2020.3

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Language：English Publishing type：Research paper (scientific journal)
Molecular pathogenesis of disease progression in MLL-rearranged AML Reviewed

Shinichi Kotani, Akinori Yoda, Ayana Kon, Keisuke Kataoka, Yotaro Ochi, Yusuke Shiozawa, Cassandra Hirsch, June Takeda, Hiroo Ueno, Tetsuichi Yoshizato, Kenichi Yoshida, Masahiro M. Nakagawa, Yasuhito Nannya, Nobuyuki Kakiuchi, Takuji Yamauchi, Kosuke Aoki, Yuichi Shiraishi, Satoru Miyano, Takahiro Maeda, Jaroslaw P. Maciejewski, Akifumi Takaori-Kondo, Seishi Ogawa, Hideki Makishima

Leukemia 33 ( 3 ) 612 - 624 2019.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41375-018-0253-3
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS Reviewed

Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al-Raqad, Manami Maeda, Vivien A.C. Schoonenberg, Mitchel A. Cole, Claudio Macias-Trevino, Yuichi Ishikawa, Qiuming Yao, Michitaka Nakano, Fumio Arai, Stuart H. Orkin, Bruno Reversade, Silvia Buonamici, Luca Pinello, Koichi Akashi, Daniel E. Bauer, Takahiro Maeda

Cancer Cell 33 ( 3 ) 386 - 400.e5 2018.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.ccell.2018.01.012
The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia Reviewed

J. Luis Espinoza, Mahmoud I. Elbadry, Masafumi Taniwaki, Kenichi Harada, Ly Quoc Trung, Noriharu Nakagawa, Akiyoshi Takami, Ken Ishiyama, Takuji Yamauchi, Katsuto Takenaka, Shinji Nakao

Cancer Letters 400 127 - 136 2017.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.canlet.2017.04.027
Composite lymphoma of peripheral T-cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis Reviewed

Ayako Ichikawa, Hiroaki Miyoshi, Takuji Yamauchi, Fumiko Arakawa, Riko Kawano, Hiroko Muta, Yasuo Sugita, Koichi Akashi, Koichi Ohshima

Pathology International 67 ( 4 ) 194 - 201 2017.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pin.12515
Mobilization of human immature hematopoietic progenitors through combinatory use of bortezomib and immunomodulatory drugs Reviewed

Taro Tochigi, Takatoshi Aoki, Yoshikane Kikushige, Tomohiko Kamimura, Yoshikiyo Ito, Takahiro Shima, Takuji Yamauchi, Yasuo Mori, Goichi Yoshimoto, Kenjiro Kamezaki, Koji Kato, Katsuto Takenaka, Hiromi Iwasaki, Koichi Akashi, Toshihiro Miyamoto

International journal of hematology 105 ( 4 ) 423 - 432 2017.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12185-016-2148-2
Calreticulin mutation does not contribute to disease progression in essential thrombocythemia by inhibiting phagocytosis Reviewed

Shinya Daitoku, Katsuto Takenaka, Takuji Yamauchi, Ayano Yurino, Fumiaki Jinnouchi, Takuya Nunomura, Tetsuya Eto, Tomohiko Kamimura, Masakazu Higuchi, Naoki Harada, Noriyuki Saito, Toshihiro Miyamoto, Hiromi Iwasaki, Koichi Akashi

Experimental Hematology 44 ( 9 ) 817 - 825.e3 2016.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.exphem.2016.05.001
Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease Reviewed

Takeshi Sugio, Koji Kato, Takatoshi Aoki, Takanori Ohta, Noriyuki Saito, Shuro Yoshida, Ichiro Kawano, Hideho Henzan, Masanori Kadowaki, Ken Takase, Tsuyoshi Muta, Kohta Miyawaki, Takuji Yamauchi, Takahiro Shima, Shuichiro Takashima, Yasuo Mori, Goichi Yoshimoto, Kenjiro Kamezaki, Katsuto Takenaka, Hiromi Iwasaki, Ryosuke Ogawa, Yuju Ohno, Tetsuya Eto, Tomohiko Kamimura, Toshihiro Miyamoto, Koichi Akashi

Biology of Blood and Marrow Transplantation 22 ( 9 ) 1608 - 1614 2016.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbmt.2016.05.017
Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit^Wv Mutations Reviewed

Ayano Yurino, Katsuto Takenaka, Takuji Yamauchi, Takuya Nunomura, Yasufumi Uehara, Fumiaki Jinnouchi, Kohta Miyawaki, Yoshikane Kikushige, Koji Kato, Toshihiro Miyamoto, Hiromi Iwasaki, Yuya Kunisaki, Koichi Akashi

Stem Cell Reports 7 ( 3 ) 425 - 438 2016.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.stemcr.2016.07.002
Preserved in vivo reconstitution ability of PBSCs cryopreserved for a decade at -80 °c Reviewed

50 ( 9 ) 1195 - 1200 2015.9

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Language：English Publishing type：Research paper (scientific journal)

PBSC products for auto- and allografting can be cryopreserved in liquid nitrogen with controlled-rate freezing until their use. Alternatively, they can be stored at -80 °C in a mechanical chest freezer, but it remains to be clarified whether PBSCs can be stored for the long term. We evaluated viability and functions of PBSCs cryopreserved for more than 10 years with this simplified method. Although recovery rate and viability of CD34 + cells were significantly decreased, myeloid differentiation potential and in vivo reconstitution and self-renewal potential of CD34 + cells in a xenogeneic engraftment assay were maintained for more than 10 years. These results indicate that PBSCs can be stored at -80 °C for years. Although accumulation of clinical engraftment data is required to confirm our results, this simplified cryopreservation will thus meet the increasing worldwide demand for PBSC transplantation in a region with limited resources.

DOI： 10.1038/bmt.2015.147
The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment Reviewed

Chika Iwamoto, Katsuto Takenaka, Shingo Urata, Takuji Yamauchi, Takahiro Shima, Takuro Kuriyama, Shinya Daitoku, Yasuyuki Saito, Toshihiro Miyamoto, Hiromi Iwasaki, Issay Kitabayashi, Katsuhiko Itoh, Junji Kishimoto, Daisuke Kohda, Takashi Matozaki, Koichi Akashi

Experimental Hematology 42 ( 3 ) 163 - 171.e1 2014.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.exphem.2013.11.005
A novel filtration method for cord blood processing using a polyester fabric filter Reviewed

T. Shima, N. Forraz, N. Sato, T. Yamauchi, H. Iwasaki, Katsuto Takenaka, K. Akashi, C. Mcguckin, T. Teshima

International Journal of Laboratory Hematology 35 ( 4 ) 436 - 446 2013.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/ijlh.12039
Contribution of Bone Marrow-Derived Hematopoietic Stem/Progenitor Cells to the Generation of Donor-Marker⁺ Cardiomyocytes In Vivo Reviewed

Mitsuhiro Fukata, Fumihiko Ishikawa, Yuho Najima, Takuji Yamauchi, Yoriko Saito, Katsuto Takenaka, Kohta Miyawaki, Hideki Shimazu, Kazuya Shimoda, Takaaki Kanemaru, Kei ichiro Nakamura, Keita Odashiro, Koji Nagafuji, Mine Harada, Koichi Akashi

PloS one 8 ( 5 ) 2013.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0062506
Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment Reviewed

Takuji Yamauchi, Katsuto Takenaka, Shingo Urata, Takahiro Shima, Yoshikane Kikushige, Takahito Tokuyama, Chika Iwamoto, Mariko Nishihara, Hiromi Iwasaki, Toshihiro Miyamoto, Nakayuki Honma, Miki Nakao, Takashi Matozaki, Koichi Akashi

Blood 121 ( 8 ) 1316 - 1325 2013.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1182/blood-2012-06-440354
Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis Reviewed

Takuro Kuriyama, Katsuto Takenaka, Kentaro Kohno, Takuji Yamauchi, Shinya Daitoku, Goichi Yoshimoto, Yoshikane Kikushige, Junji Kishimoto, Yasunobu Abe, Naoki Harada, Toshihiro Miyamoto, Hiromi Iwasaki, Takanori Teshima, Koichi Akashi

Blood 120 ( 19 ) 4058 - 4067 2012.11

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1182/blood-2012-02-408864
Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia Reviewed

Yoshikane Kikushige, Fumihiko Ishikawa, Toshihiro Miyamoto, Takahiro Shima, Shingo Urata, Goichi Yoshimoto, Yasuo Mori, Tadafumi Iino, Takuji Yamauchi, Tetsuya Eto, Hiroaki Niiro, Hiromi Iwasaki, Katsuto Takenaka, Koichi Akashi

Cancer Cell 20 ( 2 ) 246 - 259 2011.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.ccr.2011.06.029
Successful allogeneic stem cell transplantation in two patients with acute myelogenous leukaemia and invasive aspergillosis by antifungal combination therapy Reviewed

Takatoshi Aoki, Toshihiro Miyamoto, Yasuo Mori, Goichi Yoshimoto, Takuji Yamauchi, Kenjiro Kamezaki, Katsuto Takenaka, Hiromi Iwasaki, Naoki Harada, Koji Nagafuji, Nobuyuki Shimono, Takanori Teshima, Koichi Akashi

Mycoses 54 ( 4 ) e255 - e259 2011.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1439-0507.2010.01858.x
JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation Research paper Reviewed

Seido Oku, Katsuto Takenaka, Takuro Kuriyama, Kotaro Shide, Takashi Kumano, Yoshikane Kikushige, Shingo Urata, Takuji Yamauchi, Chika Iwamoto, Haruko K. Shimoda, Toshihiro Miyamoto, Koji Nagafuji, Junji Kishimoto, Kazuya Shimoda, Koichi Akashi

British Journal of Haematology 150 ( 3 ) 334 - 344 2010.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1365-2141.2010.08249.x
Cord blood stem cell transplantation in a patient with disseminated mucormycosis and acute myelogenous leukemia Reviewed

T. Aoki, K. Kamezaki, T. Miyamoto, K. Nagafuji, Y. Mori, T. Yamauchi, K. Takenaka, H. Iwasaki, N. Harada, N. Shimono, T. Teshima, K. Akashi

Transplant Infectious Disease 12 ( 3 ) 277 - 279 2010.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1399-3062.2010.00496.x
Successful treatment of refractory advanced nasal NK/T cell lymphoma with unrelated cord blood stem cell transplantation incorporating focal irradiation Reviewed

Yasuo Mori, Takatoshi Aoki, Katsuto Takenaka, Takuji Yamauchi, Asataro Yamamoto, Kenjiro Kamezaki, Hiromi Iwasaki, Naoki Harada, Toshihiro Miyamoto, Koji Nagafuji, Takanori Teshima, Koichi Akashi

International journal of hematology 91 ( 1 ) 107 - 111 2010.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12185-009-0453-8
A case of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome, complicated with disseminated M. abscessus infection Reviewed

Yukari Asai, Hiroshi Ouchi, Tukasa Ohosima, Ryuji Nakano, Yujiro Yamano, Ichiro Inoshima, Takuji Yamauchi, Satoshi Fukuyama, Hiromasa Inoue, Yoichi Nakanishi

47 ( 12 ) 1120 - 1125 2009.12

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Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9 Reviewed

Takatoshi Aoki, Toshihiro Miyamoto, Shuro Yoshida, Asataro Yamamoto, Takuji Yamauchi, Goichi Yoshimoto, Yasuo Mori, Kenjiro Kamezaki, Hiromi Iwasaki, Katsuto Takenaka, Naoki Harada, Koji Nagafuji, Takanori Teshima, Koichi Akashi

International journal of hematology 88 ( 5 ) 571 - 574 2009.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12185-008-0198-9
Second unrelated cord blood transplantation using a reduced-intensity conditioning regimen combined with gemtuzumab ozogamicin in patients with relapsed acute myelogenous leukemia Reviewed

Takuji Yamauchi, Yasuo Mori, Toshihiro Miyamoto, Kenjiro Kamezaki, Takatoshi Aoki, Asataro Yamamoto, Katsuto Takenaka, Hiromi Iwasaki, Naoki Harada, Koji Nagafuji, Takanori Teshima, Koichi Akashi

International journal of hematology 90 ( 3 ) 416 - 420 2009.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12185-009-0405-3

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Presentations

Optimization of the apheresis collecting lymphocytes for manufacturing CAR-T cells

Takuji Yamauchi, Ikumi Yamanaka, Tomoko Henzan, Teppei Sakoda, Takahiro Maeda and Yuya Kunisaki

2022.6

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Event date： 2022.5

Language：English

Country：Japan
PAICS, a de novo purine synthetic enzyme, is a novel target for AML therapy International conference

Takuji Yamauchi, Kohta Miyawaki, Yuichiro Semba, Fumihiko Nakao, Jumpei Nogami, Takeshi Sugio, Kensuke Sasaki, Matthew C. Canver, Simon Osborne, Luca Pinello, Deborah Taylor, Daniel E. Bauer, Koichi Akashi and Takahiro Maeda

ASH 2019.12

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Event date： 2020.6

Language：English

Country：United States
Identification of novel therapeutic targets in acute myeloid leukemia via a genome-wide CRISPR/Cas9 screen Invited

2018.10

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Event date： 2019.6

Language：English Presentation type：Symposium, workshop panel (public)

Country：Japan

Research Projects

BCL2阻害剤を用いた新規AML治療法の開発

Grant number：23K07860 2023 - 2025

日本学術振興会科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
CRISPR/Cas9 システムを用いたAML新規治療標的の同定

2019.6
CRISPRスクリーニングを用いたATRA併用AML新規分化誘導療法の開発

Grant number：19K17859 2019 - 2021

日本学術振興会科学研究費助成事業若手研究

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Authorship：Principal investigator Grant type：Scientific research funding
急性骨髄性白血病に対するCRISPR全ゲノム機能的スクリーニング・新規治療法開発

Grant number：18K16088 2019 - 2021

日本学術振興会科学研究費助成事業若手研究

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Authorship：Principal investigator Grant type：Scientific research funding

Class subject

骨髄増殖性腫瘍

2021.4 - 2021.9 First semester
骨髄増殖性腫瘍

2020.4 - 2020.9 First semester
骨髄増殖性腫瘍

2019.4 - 2019.9 First semester

Specialized clinical area

Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Hematology

Clinician qualification

専門医・指導医・評議員

日本血液学会
Certifying physician

日本輸血・細胞治療学会
Certifying physician

The Japanese Society of Internal Medicine（JSIM）

Year of medical license acquisition

2006