研究者詳細 - 江里口芳裕

お知らせ

写真a

エリグチ　ヨシヒロ

江里口芳裕

ERIGUCHI YOSHIHIRO

所属

九州大学病院免疫・膠原病・感染症内科助教
医学部医学科（併任）

電話番号

0926425228

プロフィール

移植片対宿主病と感染免疫に関する研究新型コロナウイルスの宿主免疫に関する研究臨床医学実習のベッドサイド、クリニカルクラークシップでの学生指導臨床実習前OSCE（実技試験）評価者共用試験医学系臨床実習後OSCE（Post-cc OSCE）評価者

ホームページ

http://www.1nai.med.kyushu-u.ac.jp/

外部リンク

学位

医学博士

経歴

佐賀大学（消化器内科） Keck School of Medicine of USC, Department of Pathology and Laboratory Medicine (Postdoctoral Scholar-Research Associate)

研究テーマ・研究キーワード

研究テーマ：腸管GVHDと腸内菌叢のクロストーク、腸管免疫

研究キーワード：腸管GVHD、腸内菌叢、腸管免疫

研究期間： 2006年4月 - 2012年12月

受賞

Best Research Paper Publication in the Postdoctoral Scholar Category at The 22nd Annual Pathology　Conference, Keck School of Medicine of USC

2019年2月 Keck School of Medicine of USC Essential role of interferon-gamma in T cell-associated intestinal inflammation
Best Poster Presentation Honorable Mention in the Postdoctoral Scholar Category at The 19th Annual Pathology Conference, Keck School of Medicine of USC

2016年2月 Keck School of Medicine of USC Rhesus Theta Defensin-1 Mediated Effects on T cell Responses
平成25年度　日本感染症学会　西日本地方会　感染症優秀論文賞（基礎的研究領域）

2013年11月日本感染症学会 Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. 江里口芳裕（Dept. Pathology & Lab Medicine, Keck School of Medicine of University of Southern California） Blood. 2012; 120: 223-231.
52nd ASH Travel Award, 52nd American Society of Hematology Annual Meeting and Exposition

2010年12月 American Society of Hematology 発表演題「Graft-Versus-Host Disease Alters Intestinal Microbial Ecology by Inhibiting Production of Enteric Defensins」

論文

Breakthrough candidemia with hematological disease: Results from a single-center retrospective study in Japan, 2009–2020 査読

Nishida, R; Eriguchi, Y; Miyake, N; Nagasaki, Y; Yonekawa, A; Mori, Y; Kato, K; Akashi, K; Shimono, N

MEDICAL MYCOLOGY 61 ( 6 ) 2023年6月（ ISSN:1369-3786 eISSN:1460-2709 ）

　詳細を見る

記述言語：その他掲載種別：研究論文（学術雑誌）出版者・発行元：Medical Mycology

Breakthrough candidemia (BrC) is a significant problem in immunocompromised patients, particularly those with hematological disorders. To assess the characteristics of BrC in patients with hematologic disease treated with novel antifungal agents, we collected clinical and microbiological information on said patients from 2009 to 2020 in our institution. Forty cases were identified, of which 29 (72.5%) received hematopoietic stem cell transplant (HSCT)-related therapy. At BrC onset, the most administered class of antifungal agents were echinocandins, administered to 70% of patients. Candida guilliermondii complex was the most frequently isolated species (32.5%), followed by C. parapsilosis (30%). These two isolates were echinocandin-susceptible in vitro but had naturally occurring FKS gene polymorphisms that reduced echinocandin susceptibility. Frequent isolation of these echinocandin-reduced-susceptible strains in BrC may be associated with the widespread use of echinocandins. In this study, the 30-day crude mortality rate in the group receiving HSCT-related therapy was significantly higher than in the group not receiving it (55.2% versus 18.2%, P =. 0297). Most patients affected by C. guilliermondii complex BrC (92.3%) received HSCT-related therapy and had a 30-day mortality rate of 53.8%; despite treatment administration, 3 of 13 patients had persistent candidemia. Based on our results, C. guilliermondii complex BrC is a potentially fatal condition in patients receiving HSCT-related therapy with echinocandin administration.

DOI： 10.1093/mmy/myad056

Web of Science

Scopus

PubMed

researchmap
Essential role of IFN-γ in T cell-associated intestinal inflammation 査読

Yoshihiro Eriguchi, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Shuichiro Takahashi, Daigo Hashimoto, Takanori Teshima, Tokiyoshi Ayabe, Michael E. Selsted, André J. Ouellette

JCI Insight 3 ( 18 ) 2018年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Paneth cells contribute to small intestinal homeostasis by secreting antimicrobial peptides and constituting the intestinal stem cell (ISC) niche. Certain T cell-mediated enteropathies are characterized by extensive Paneth cell depletion coincident with mucosal destruction and dysbiosis. In this study, mechanisms of intestinal crypt injury have been investigated by characterizing responses of mouse intestinal organoids (enteroids) in coculture with mouse T lymphocytes. Activated T cells induced enteroid damage, reduced Paneth cell and Lgr5+ ISC mRNA levels, and induced Paneth cell death through a caspase-3/7-dependent mechanism. IFN-γ mediated these effects, because IFN-γ receptor-null enteroids were unaffected by activated T cells. In mice, administration of IFN-γ induced enteropathy with crypt hyperplasia, villus shortening, Paneth cell depletion, and modified ISC marker expression. IFN-γ exacerbated radiation enteritis, which was ameliorated by treatment with a selective JAK1/2 inhibitor. Thus, IFN-γ induced Paneth cell death and impaired regeneration of small intestinal epithelium in vivo, suggesting that IFN-γ may be a useful target for treating defective mucosal regeneration in enteric inflammation.

DOI： 10.1172/jci.insight.121886
Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins 査読国際誌

Yoshihiro Eriguchi, Shuichiro Takashima, Hideyo Oka, Sonoko Shimoji, Kiminori Nakamura, Hidetaka Uryu, Shinji Shimoda, Hiromi Iwasaki, Nobuyuki Shimono, Tokiyoshi Ayabe, Koichi Akashi, and Takanori Teshima

Blood 120 ( 1 ) 2012年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

同種造血幹細胞移植は様々な血液疾患に対して根治的な治療方法である。移植片対宿主病（Graft-versus-host disease ：GVHD）と感染症は、この造血幹細胞移植の厄介な合併症であり、GVHDと感染症は互いに影響を与えていると推測されている。本研究では、GVHDと感染症の相互関係をマウスモデルにより解析した。
　αディフェンシンは、病原菌に対し殺菌活性があり、共生菌に対しては活性を有さない選択的抗菌活性を持った抗菌ペプチドである。Paneth細胞は、このαディフェンシンを分泌することにより腸内細菌叢を制御している。我々は、Paneth細胞がGVHDの標的となり、腸管でのαディフェンシンの発現が減少することを発見した。
　腸内細菌叢の分子生物学的解析では、GVHD発症マウスで腸内細菌叢の多様性が減少する一方で、正常細菌叢では0.1％にも満たず、敗血症の病因となる大腸菌が異常増殖することを示した。この細菌叢の変化は、GVHD発症マウスにのみみられ、移植前処置である放射線照射による腸管障害とは無関係であり、菌叢の変化の度合いはGVHDの重症度と有意に相関した。また、大腸菌に抗菌活性のあるポリミキシンBの経口投与は、大腸菌の異常増殖を抑え、GVHDを軽減した。
　これらの結果は、GVHD発症により正常腸内細菌叢から、病原菌が爆発的に増加した異常細菌叢へと変移する新規のメカニズムと、今まで認識されていなかったGVHDと同種造血幹細胞移植後に発症する感染症との関連を明らかにした。

DOI： doi:10.1182/blood-2011-12-401166
Clinical and virological features of SARS-CoV-2 Omicron variant-infected immunocompromised patients receiving immunosuppressive medications

Nakamura, K; Goto, T; Shiraishi, K; Yonekawa, A; Eriguchi, Y; Akashi, K; Shimono, N; Chong, Y

BMC INFECTIOUS DISEASES 24 ( 1 ) 736 2024年7月（ eISSN:1471-2334 ）

　詳細を見る

記述言語：英語出版者・発行元：BMC Infectious Diseases

Background: The prognosis of immunocompromised individuals with COVID-19 remains a significant concern. Information regarding the clinical and virological characteristics of immunocompromised patients infected with SARS-CoV-2 during the Omicron variant period is limited. Methods: Medical records of patients admitted to our hospital with COVID-19 during the Omicron (BA.1–5) epidemic were retrospectively reviewed. Clinical, virological (nasopharyngeal swabs and blood), and serological data were compared between immunocompromised patients receiving immunosuppressive medications (calcineurin inhibitors, mycophenolate mofetil, or steroids) and control patients not receiving immunosuppressive medications. Results: Twenty-eight immunocompromised patients (25 transplant recipients) and 26 control patients were included. Fourteen of the immunocompromised patients (50%) received monoclonal antibodies. The immunocompromised group included 15 mild/moderate (53.6%), 10 severe (35.7%), and three critical (10.7%) disease severities. The mortality rate due to COVID-19 during hospitalization was 3.6% (1/28) in the immunocompromised group, with no difference between the two groups. Three cases of re-exacerbation after discharge occurred in the immunocompromised group and none in the control group. Linear regression based on nasopharyngeal real-time-PCR cycle threshold (Ct) values according to the time since symptom onset showed markedly slower viral clearance in the immunocompromised group than in the control group (Pslope = 0.078). In the immunocompromised group, patients who received monoclonal antibodies showed faster viral clearance than those who did not receive monoclonal antibodies. The convalescent anti-spike IgG titers were comparable to those in the control group in patients who received monoclonal antibodies and significantly lower than those in the control patients in patients who did not receive monoclonal antibodies (P < 0.001). The prevalence of viremia at onset was significantly higher in the immunocompromised group than in the control group (35.7%, [10/28] vs. 11.5%, [3/26]; P = 0.003). All three patients with critical disease severity in the immunocompromised group exhibited viremia, one of whom died. All three patients with viremia in the control group were critical, of whom two died. Conclusions: Immunocompromised individuals receiving immunosuppressive medications are more likely to show delayed post-infection SARS-CoV-2 viral clearance and the development of viremia, potentially resulting in worsening severity and outcomes, especially in viremic patients, even during the Omicron epidemic.

DOI： 10.1186/s12879-024-09633-1

Web of Science

Scopus

PubMed
Streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis from retroperitoneal panniculitis during the treatment with anti-IL-6 receptor antibody: A case report(タイトル和訳中)

Fujimoto Sho, Eriguchi Yoshihiro, Nakamura Rinto, Kamikawa Sota, Yonekawa Akiko, Miyake Noriko, Ono Nobuyuki, Niiro Hiroaki

Modern Rheumatology Case Reports 8 ( 2 ) 255 - 258 2024年7月

　詳細を見る

記述言語：英語出版者・発行元：Oxford University Press
Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study

Matsubara Y., Kiyohara H., Mikami Y., Nanki K., Namkoong H., Chubachi S., Tanaka H., Azekawa S., Sugimoto S., Yoshimatsu Y., Sujino T., Takabayashi K., Hosoe N., Sato T., Ishii M., Hasegawa N., Okada Y., Koike R., Kitagawa Y., Kimura A., Imoto S., Miyano S., Ogawa S., Fukunaga K., Kanai T., Chubachi S., Namkoong H., Fukushima T., Tanaka H., Lee H., Otake S., Nakagawara K., Morita A., Watase M., Sakurai K., Ogawa T., Kusumoto T., Masaki K., Kabata H., Ikemura S., Okamori S., Terai H., Kamata H., Uchida S., Uno S., Hasegawa N., Takahashi K., Sasano H., Kitagawa Y., Harada N., Takagi H., Nakamura A., Naito T., Hiki M., Matsushita Y., Aoki R., Harada S., Sasaki J., Morisaki H., Uwamino Y., Mikami Y., Ishihara R., Matsubara Y., Kiyohara H., Sugimoto S., Yoshimatsu Y., Nishimura T., Sato T., Ueda T., Azuma M., Saito R., Sado T., Miyazaki Y., Sato R., Haruta Y., Nagasaki T., Hasegawa Y., Yasui Y., Ueda S., Tada A., Miyawaki M., Yamamoto M., Yoshida E., Hayashi R., Nagasaka T., Arai S., Kaneko Y., Sasaki K., Ishiguro T., Isono T., Shibata S., Matsui Y., Hosoda C., Takano K., Nishida T., Kobayashi Y., Takaku Y., Takayanagi N., Tagaya E.

Journal of Gastroenterology 59 ( 3 ) 195 - 208 2024年3月（ ISSN:09441174 ）

　詳細を見る

出版者・発行元：Journal of Gastroenterology

Background: Research on whether gastrointestinal symptoms correlate with the severity of Coronavirus Disease 2019 (COVID-19) has been inconclusive. This study aimed to clarify any associations between gastrointestinal symptoms and the prognosis of COVID-19. Methods: We collected data from the Japanese nationwide registry for COVID-19 to conduct a retrospective cohort study. Data from 3498 Japanese COVID-19 patients, diagnosed at 74 facilities between February 2020 and August 2022, were analyzed in this study. Hospitalized patients were followed up until discharge or transfer to another hospital. Outpatients were observed until the end of treatment. Associations between gastrointestinal symptoms and clinical outcomes were investigated using multivariable-adjusted logistic regression models. Results: The prevalence of diarrhea, nausea/vomiting, abdominal pain, and melena were 16.6% (581/3498), 8.9% (311/3498), 3.5% (121/3498), and 0.7% (23/3498), respectively. In the univariable analysis, admission to intensive care unit (ICU) and requirement for mechanical ventilation were less common in patients with diarrhea than those without (ICU, 15.7% vs. 20.6% (p = 0.006); mechanical ventilation, 7.9% vs. 11.4% (p = 0.013)). In the multivariable-adjusted analysis, diarrhea was associated with lower likelihood of ICU admission (adjusted odds ratio (aOR), 0.70; 95% confidence interval (CI), 0.53–0.92) and mechanical ventilation (aOR, 0.61; 95% CI, 0.42–0.89). Similar results were obtained in a sensitivity analysis with another logistic regression model that adjusted for 14 possible covariates with diarrhea (ICU; aOR, 0.70; 95% CI, 0.53–0.93; mechanical ventilation; aOR 0.62; 95% CI, 0.42–0.92). Conclusions: Diarrhea was associated with better clinical outcomes in COVID-19 patients.

DOI： 10.1007/s00535-023-02071-x

Scopus
Streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis from retroperitoneal panniculitis during the treatment with anti-IL-6 receptor antibody: A case report 査読

Fujimoto, S; Eriguchi, Y; Nakamura, R; Kamikawa, S; Yonekawa, A; Miyake, N; Ono, N; Niiro, H

MODERN RHEUMATOLOGY CASE REPORTS 8 ( 2 ) 255 - 258 2024年1月（ eISSN:2472-5625 ）

　詳細を見る

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Modern Rheumatology Case Reports

A 53-year-old man with adult-onset Still’s disease developed severe streptococcal toxic shock syndrome (STSS) due to Streptococcus dysgalactiae subsp. equisimilis (SDSE), following retroperitoneal panniculitis. He was receiving tocilizumab (TCZ), an interleukin-6 receptor inhibitor. The modifying effect of TCZ on the immune response and the pathophysiology of SDSE infection may have led to retroperitoneal panniculitis and atypical STSS with delayed shock and flare of soft tissue inflammation.

DOI： 10.1093/mrcr/rxae001

Web of Science

Scopus

PubMed

researchmap
A second update on mapping the human genetic architecture of COVID-19

Kanai, M; Andrews, SJ; Cordioli, M; Stevens, C; Neale, BM; Daly, M; Ganna, A; Kanai, M; Andrews, SJ; Cordioli, M; Pathak, GA; Ganna, A; Iwasaki, A; Karjalainen, J; Mehtonen, J; Pathak, GA; Andrews, SJ; Kanai, M; Cordioli, M; Pirinen, M; Stevens, C; Chwialkowska, K; Trankiem, A; Balaconis, MK; Veerapen, K; Wolford, BN; Ahmad, HF; Andrews, S; Puoti, KAV; Boer, C; Boua, PR; Butler-Laporte, G; Cadilla, CL; Chwialkowska, K; Colombo, F; Douillard, V; Dueker, N; Dutta, AK; El-Sherbiny, YM; Eltoukhy, MM; Esmaeeli, S; Faucon, A; Fave, MJ; Cadenas, IF; Francescatto, M; Francioli, L; Franke, L; Fuentes, M; Durán, RG; Cabrero, DG; Harry, EN; Jansen, P; Szentpéteri, JL; Kaja, E; Kanai, M; Kirk, C; Kousathanas, A; Krieger, JE; Patel, SK; Lemaçon, A; Limou, S; Lió, P; Marouli, E; Marttila, MM; Medina-Gómez, C; Michaeli, Y; Migeotte, I; Mondal, S; Moreno-Estrada, A; Moya, L; Nakanishi, T; Nasir, J; Pasko, D; Pathak, GA; Pearson, NM; Pereira, AC; Priest, J; Prijatelj, V; Prokic, I; Teumer, A; Várnai, R; Romero-Gómez, M; Roos, C; Rosenfeld, J; Ruolin, L; Schulte, EC; Schurmann, C; Sedaghati-Khayat, B; Shaheen, D; Shivanathan, I; Sipeky, C; Sirui, Z; Striano, P; Tanigawa, Y; Remesal, AU; Vadgama, N; Vallerga, CL; Van der Laan, S; Verdugo, RA; Wang, QBS; Wei, Z; Zainulabid, UA; Zárate, RN; Auton, A; Shelton, JF; Shastri, AJ; Weldon, CH; Filshtein-Sonmez, T; Coker, D; Symons, A; Aslibekyan, S; O'Connell, J; Ye, C; Weldon, CH; Hatoum, AS; Agrawal, A; Bogdan, R; Colbert, SMC; Thompson, WK; Fan, CC; Johnson, EC; Niazyan, L; Davidyants, M; Arakelyan, A; Avetyan, D; Bekbossynova, M; Tauekelova, A; Tuleutayev, M; Sailybayeva, A; Ramankulov, Y; Zholdybayeva, E; Dzharmukhanov, J; Kassymbek, K; Tsechoeva, T; Turebayeva, G; Smagulova, Z; Muratov, T; Khamitov, S; Kwong, ASF; Timpson, NJ; Niemi, MEK; Rahmouni, S; Guntz, J; Migeotte, I; Beguin, Y; Cordioli, M; Pigazzini, S; Nkambule, L; Georges, M; Moutschen, M; Misset, B; Darcis, G; Gofflot, S; Bouysran, Y; Busson, A; Peyrassol, X; Wilkin, F; Pichon, B; Smits, G; Vandernoot, I; Goffard, JC; Tiembe, N; Nakanishi, T; Morrison, DR; Afilalo, J; Mooser, V; Richards, JB; Rousseau, S; Durand, M; Butler-Laporte, G; Forgetta, V; Laurent, L; Afrasiabi, Z; Bouab, M; Tselios, C; Xue, XQ; Afilalo, M; Oliveira, M; St-Cyr, J; Boisclair, A; Ragoussis, J; Auld, D; Kaufmann, DE; Lathrop, GM; Bourque, G; Décary, S; Falcone, EL; Montpetit, A; Piché, A; Renoux, C; Tremblay, K; Tse, SM; Zawati, MH; Davis, LK; Cox, NJ; Below, JE; Sealock, JM; Faucon, AB; Shuey, MM; Polikowsky, HG; Petty, LE; Shaw, DM; Chen, HH; Zhu, WY; Schmidt, A; Ludwig, KU; Maj, C; Rolker, S; Balla, D; Behzad, P; Nöthen, MM; Fazaal, J; Keitel, V; Keitel, V; Jensen, BEO; Feldt, T; Marx, N; Dreher, M; Pink, I; Cornberg, M; Illig, T; Lehmann, C; Schommers, P; Rybniker, J; Augustin, M; Knopp, L; Kurth, I; Eggermann, T; Volland, S; Berger, MM; Brenner, T; Hinney, A; Witzke, O; Konik, MJ; Bals, R; Herr, C; Ludwig, N; Walter, J; Latz, E; Schmidt, SV; Brooks, JD; Bull, S; Elliott, LT; Gagnon, F; Greenwood, CMT; Hung, RJ; Lawless, JF; Paterson, AD; Sun, L; Rauh, M; Briollais, L; Gingras, AC; Bombard, Y; Pugh, TJ; Simpson, J; Goneau, LW; Halevy, AR; Maslove, DM; Borgundvaag, B; Devine, L; Bearss, E; Richardson, D; Arnoldo, S; Friedman, SM; Taher, A; Stern, S; Dagher, M; Vasilevska-Ristovska, J; Biggs, CM; Mickiewicz, B; Strug, LJ; Scherer, SW; Aziz, N; Jones, SJM; Knoppers, BM; Lathrop, M; Turvey, SE; Yeung, RSM; Allen, U; Cheung, AM; Herridge, MS; Hunt, M; Lerner-Ellis, J; Taher, J; Parekh, RS; Hiraki, LT; Cowan, J; Ducharme, FM; Ostrowski, M; Bernier, FP; Kellner, J; Garg, E; Yoo, S; Vlasschaert, C; Frangione, E; Chung, M; Noor, A; Greenfeld, E; Colwill, K; Clausen, M; Chao, G; Yue, F; Fritzler, M; Whitney, J; Thiruvahindrapuram, B; Garant, JM; Abraham, R; Davis, A; Campigotto, A; Papenburg, J; Niranjan, K; Betschel, S; Sadarangani, M; Barton-Forbes, M; Hanley, M; Fung, CYJ; Lapadula, E; MacDonald, G; Puopolo, M; Kaushik, D; Nirmalanathan, K; Wong, I; Khan, Z; Zarei, N; Michalowska, M; Modi, BP; Persia, P; Estacio, A; Buchholz, M; Cheatley, PL; Lorenti, M; Aman, NF; Matveev, V; Budylowski, P; Upton, J; Morris, S; Boyd, T; Chowdhary, S; Casalino, S; Morgan, G; Mighton, C; McGeer, A; Mazzulli, T; McLeod, SL; Binnie, A; Faghfoury, H; Chertkow, H; Racher, H; Serbanescu, MA; Pavenski, K; Esser, M; Thompson, G; Herbrick, JA; Gignoux, CR; Wicks, SJ; Crooks, K; Barnes, KC; Daya, M; Shortt, J; Rafaels, N; Chavan, S; Ganna, A; Schulze, TG; Schulte, EC; Heilbronner, U; Papiol, S; Cordioli, M; Corbetta, A; Wendtner, CM; Spinner, CD; Erber, J; Schneider, J; Winter, C; Wiltfang, J; Budde, M; Senner, F; Kalman, JL; Protzer, U; Mueller, NS; Mousas, A; Liontos, A; Christaki, E; Milionis, H; Tsilidis, K; Asimakopoulos, A; Kanellopoulou, A; Markozannes, G; Biros, D; Milionis, O; Tsourlos, S; Athanasiou, L; Kolios, NG; Pappa, C; Papathanasiou, A; Pargana, E; Nasiou, M; Kosmidou, M; Rapti, I; Ntotsikas, E; Chaliasos, K; Ntzani, E; Evangelou, E; Gartzonika, K; Georgiou, I; Tzoulaki, I; Ellinghaus, D; Degenhardt, F; Cáceres, M; Juzenas, S; Lenz, TL; Albillos, A; Julià, A; Prati, D; Solligård, E; Garcia, F; Tran, F; Hanses, F; Baselli, G; Zoller, H; Holter, JC; Fernández, J; Barretina, J; Valenti, L; Bujanda, L; Romero-Gómez, M; Buti, M; D'Amato, M; Banales, JM; Rosenstiel, P; Koehler, P; Invernizzi, P; de Cid, R; Asselta, R; Schreiber, S; Duga, S; Hehr, U; Franke, A; Maya-Miles, D; Hov, JR; Karlsen, TH; Folseraas, T; Teles, A; Tanck, A; Gassner, C; Azuure, C; Wacker, EM; Uellendahl-Werth, F; Hemmrich-Stanisak, G; Elabd, H; Kässens, J; Arora, J; Lerga-Jaso, J; Wienbrandt, L; Rühlemann, MC; Wendorff, M; Basso, MEF; Vadla, MS; Wittig, M; Braun, N; Lenning, OB; Özer, O; Myhre, R; Raychaudhuri, S; Wesse, T; Albrecht, W; Yi, X; Ortiz, AB; de Salazar, A; Chercoles, AG; Palom, A; Ruiz, A; Garcia-Fernandez, AE; Blanco-Grau, A; Mantovani, A; Holten, AR; Bandera, A; Cherubini, A; Protti, A; Aghemo, A; Gerussi, A; Ramirez, A; Nebel, A; Barreira, A; Lleo, A; Kildal, AB; Biondi, A; Caballero-Garralda, A; Gori, A; Glück, A; Lind, A; Nolla, AC; Latiano, A; Fracanzani, AL; Peschuck, A; Cavallero, A; Dyrhol-Riise, AM; Ruello, A; Muscatello, A; Voza, A; Rando-Segura, A; Solier, A; Cortes, B; Mateos, B; Nafria-Jimenez, B; Schaefer, B; Bellinghausen, C; Ferrando, C; de la Horra, C; Quereda, C; Scollo, C; Lange, C; Hu, CZ; Paccapelo, C; Angelini, C; Cappadona, C; Bianco, C; Cea, C; Sancho, C; Hoff, DAL; Galimberti, D; Haschka, D; Jiménez, D; Pestaña, D; Toapanta, D; Muñiz-Diaz, E; Azzolini, E; Sandoval, E; Binatti, E; Scarpini, E; Casalone, E; Urrechaga, E; Paraboschi, EM; Pontali, E; Reverter, E; Calderón, EJ; Navas, E; Contro, E; Arana-Arri, E; Aziz, F; Sánchez, FG; Ceriotti, F; Martinelli-Boneschi, F; Peyvandi, F; Blasi, F; Malvestiti, F; Medrano, FJ; Mesonero, F; Rodriguez-Frias, F; Müller, F; Bellani, G; Pesenti, A; Zanella, A; Grasselli, G; Pezzoli, G; Costantino, G; Albano, G; Cardamone, G; Bellelli, G; Citerio, G; Foti, G; Lamorte, G; Matullo, G; Kurihara, H; Neb, H; My, I; Hernández, I; de Rojas, I; Galván-Femenia, I; Afset, JE; Heyckendorf, J; Damås, JK; Ampuero, J; Martín, J; Erdmann, J; Badia, JR; Dopazo, J; Bergan, J; Quero, JH; Goikoetxea, J; Delgado, J; Guerrero, JM; Risnes, K; Banasik, K; Müller, KE; Gaede, KI; Garcia-Etxebarria, K; Tonby, K; Heggelund, L; Bettini, LR; Sumoy, L; Terranova, L; Gustad, LT; Garbarino, L; Santoro, L; Téllez, L; Roade, L; Ostadreza, M; Intxausti, M; Kogevinas, M; Riveiro-Barciela, M; Schaefer, M; Gutiérrez-Stampa, MA; Carrabba, M; Valsecchi, MG; Hernandez-Tejero, M; Vehreschild, MJGT; Manunta, M; Acosta-Herrera, M; D'Angiò, M; Baldini, M; Cazzaniga, M; Marquie, M; Castoldi, M; Cecconi, M; Tomasi, M; Boada, M; Joannidis, M; Mazzocco, M; Ciccarelli, M; Rodríguez-Gandia, M; Bocciolone, M; Miozzo, M; Ayo, NI; Blay, N; Chueca, N; Montano, N; Martinez, N; Cornely, OA; Palmieri, O; Faverio, P; Preatoni, P; Bonfanti, P; Omodei, P; Tentorio, P; Castro, P; Rodrigues, PM; Izquierdo-Sanchez, L; España, PP; Hoffmann, P; Bacher, P; de Pablo, R; Ferrer, R; Gualtierotti, R; Gallego-Durán, R; Nieto, R; Carpani, R; Morilla, R; Badalamenti, S; Haider, S; Ciesek, S; Bombace, S; Marsal, S; Klein, S; Pelusi, S; Wilfling, S; Goerg, S; Bosari, S; Brunak, S; Heilmann-Heimbach, S; Aliberti, S; Dudman, S; Zheng, T; Bahmer, T; Pumarola, T; Cejudo, TG; Rimoldi, V; Monzani, V; Skogen, V; Friaza, V; Andrade, V; Moreno, V; Peter, W; Farre, X; Khodamoradi, Y; Grimsrud, MM; May, S; Colombo, A; Virginia, MRA; Dorador, C; Fuentes-Guajardo, M; Silva, AX; Espinosa-Parrilla, Y; Verdugo, RA; Yáñez, CE; Retamales-Ortega, RM; Hidalgo, JMS; Tobar-Calfucoy, EA; Carvajal-Silva, L; Martínez, MF; Cerpa, LC; Christian, MA; Cappelli, C; Valenzuela-Jorquera, H; Zapata-Contreras, D; Zuniga-Pacheco, P; Nova-Lamperti, EA; Sanhueza, SA; Donoso, G; Bocchieri, P; Kochifas, P; Quinones, LA; Banasik, K; Pedersen, OB; Geller, F; Westergaard, D; Sequeros, CB; Nissen, J; Nielsen, SD; Feldt-Rasmussen, U; Bliddal, S; Gronbaek, K; Brunak, S; Ullum, H; Ostrowski, SR; Feenstra, B; Niemi, MEK; Shahin, D; El-Sherbiny, YM; Puoti, KAV; Sobh, A; Eltoukhy, MM; Shoma, A; Cordioli, M; Corbetta, A; Nkambul, L; Elhadidy, TA; Abd Elghafar, MS; El-Jawhari, JJ; Mohamed, AAS; Elnagdy, MH; Samir, A; Abdel-Aziz, M; Khafaga, WT; El-Lawaty, WM; Torky, MS; El-Shanshory, MR; Elzeiny, A; Rashad, A; Mansour, TA; Yassen, AM; Hegazy, MAF; Okasha, K; Eid, MA; Hanteera, MS; Medina-Gomez, C; Ikram, MA; Uitterlinden, AG; Ripatti, S; Jermy, B; Ruotsalainen, S; Kristiansson, K; Koskelainen, S; Perola, M; Donner, K; Kivinen, K; Palotie, A; Kaunisto, M; Julienne, H; Aschard, H; Deleuze, JF; Debette, S; Tregouet, DA; Abel, L; Henches, L; Lefloch, E; Claire, DR; Sakuntabhai, A; Bourgeron, T; Olaso, R; Daian, DB; Pellegrin, I; Casanova, JL; Cobat, A; Jouanguy, E; Zhang, Q; Ghosn, J; Mentré, F; Laouénan, C; Tubiana, S; Chirouze, C; Quintana-Murci, L; Patin, E; Duffy, D; Boland, A; de Cid, R; Barretina, J; Carreras, A; Moreno, V; Kogevinas, M; Galván-Femenía, I; Blay, N; Farré, X; Sumoy, L; Cortés, B; Mercader, JM; Guindo-Martinez, M; Torrents, D; Garcia-Aymerich, J; Castaño-Vinyals, G; Dobaño, C; van Heel, DA; Hunt, KA; Trembath, RC; Jacobs, BM; Huang, QQ; Martin, HC; Mason, D; Trivedi, B; Wright, J; Munisamy, M; van Heel, DA; Hunt, KA; Finer, S; Griffiths, CJ; McCarthy, MI; Rosenberger, C; Lee, JE; Chang, D; Hammer, C; Hunkapiller, J; Mahajan, A; Pendergrass, R; Sucheston-Campbell, L; Yaspan, B; Lee, HS; Shin, E; Jang, HY; Kim, S; Kym, S; Kim, YS; Jeong, H; Kwon, KT; Kim, SW; Kim, JY; Jang, YR; Kim, HA; Lee, JY; Lee, JE; Lee, S; Choe, KW; Kang, YM; Jee, SH; Jung, KJ; Park, HY; Kim, BJ; Kim, YJ; Hwang, MY; Yoon, K; Pairo-Castineira, E; Rawlik, K; Kousathanas, A; Caulfield, MJ; Baillie, JK; Griffiths, F; Bretherick, AD; Stuckey, A; Odhams, CA; Walker, S; Russell, CD; Malinauskas, T; Wu, Y; Shen, X; Elliott, KS; Morrice, K; Keating, S; Wang, B; Rhodes, D; Klaric, L; Zechner, M; Parkinson, N; Fawkes, A; Murphy, L; Vitart, V; Wilson, JF; Yang, J; Scott, RH; Moutsianas, L; Law, A; Begg, C; Hendry, SC; Hinds, C; Horby, P; Knight, J; Ling, L; Maslove, D; McAuley, D; Millar, J; Montgomery, H; Nichol, A; Openshaw, PJM; Pereira, AC; Ponting, CP; Rowan, K; Semple, MG; Shankar-Hari, M; Summers, C; Walsh, T; Pan, J; Grau, N; Jones, TO; Lim, R; Marotti, M; Whitton, C; Bociek, A; Campos, S; Arbane, G; Ostermann, M; Cha, M; DAmato, F; Kosifidou, E; Lorah, S; Morera, K; Brady, L; Hugill, K; Henning, J; Bonner, S; Headlam, E; Jones, J; List, A; Morley, J; Welford, A; Kamangu, B; Ratnakumar, A; Shoremekun, A; Alldis, Z; Astin-Chamberlain, R; Bibi, F; Biddle, J; Blow, S; Bolton, M; Borra, C; Bowles, R; Burton, M; Choudhury, Y; Cox, A; Easthope, A; Ebano, P; Fotiadis, S; Gurasashvili, J; Halls, R; Hartridge, P; Kallon, D; Kassam, J; Lancoma-Malcolm, I; Matharu, M; May, P; Mitchelmore, O; Newman, T; Patel, M; Pheby, J; Pinzuti, I; Prime, Z; Prysyazhna, O; Shiel, J; Taylor, M; Tierney, C; Zongo, O; Wood, S; Zak, A; Collier, D; Mundy, M; Thompson, C; Pritchard, L; Gellamucho, M; Cartlidge, D; Bandla, N; Bailey, L; Davies, M; Delaney, J; Scott, L; Abdelrazik, M; Alasdair, F; Carter, D; Elhassan, M; Ganesan, A; Jenkins, S; Lamond, Z; Purohit, D; Rohit, K; Saleem, M; Wall, A; Xavier, K; Bakthavatsalam, D; Gehad, K; Gnanapragasam, P; Jain, K; Jain, S; Malik, A; Pappachan, N; Moreno-Cuesta, J; Haldeos, A; Vincent, R; Oziegb, M; Cavazza, A; Cockrell, M; Corcoran, E; Depante, M; Finney, C; Jerome, E; Knighton, A; Nayak, M; Pappa, E; Saha, R; Saha, S; Dodd, A; O'Reilly, K; McPhail, M; Clarey, E; Noble, H; Smith, J; Coghlan, P; Brett, S; Gordon, A; Templeton, M; Antcliffe, D; Banach, D; Darnell, S; Fernandez, Z; Jepson, E; Mohammed, A; Rojo, R; Arias, SS; Gurung, AT; Wong, J; Fernandez-Roman, J; Hamilton, DO; Johnson, E; Johnston, B; Martinez, ML; Mulla, S; Waite, AAC; Williams, K; Waugh, V; Welters, I; Emblem, J; Norris, M; Shaw, D; Bashyal, A; Beer, S; Hutton, P; McKechnie, S; Davidson, N; Mathew, S; Readion, G; Ryu, J; Wilson, J; Agrawal, S; Elston, K; Jones, M; Meaney, E; Polgarova, P; Elbehery, M; Daubney, E; Ng, A; Marshall, J; Pathan, N; Stroud, K; White, D; Andrew, A; Ashraf, S; Clark, A; Dent, M; Langley, M; Peters, C; Ryan, L; Sampson, J; Wei, SY; Baddeley, A; Meredith, M; Morris, L; Gibbons, A; McLoughlin, L; Delgado, CC; Clark, V; Dawson, D; Ding, LJ; Durrant, G; Ezeobu, O; Harrison, A; Hurt, WJ; Kanu, R; Kinch, A; Leaver, S; Lisboa, A; Mathew, J; Patel, K; Saluzzio, RP; Rawlins, J; Samakomva, T; Shah, N; Sicat, C; Texeira, J; De Queiroz, JG; Da Gloria, EF; Maccacari, E; Yun, N; Manna, S; Farnell-Ward, S; Maizcordoba, M; Thanasi, M; Ali, HH; Hastings, J; Grauslyte, L; Hussain, M; Ruge, B; King, S; Pogreban, T; Rosaroso, L; Smith, H; Phull, MK; Adams, N; Franke, G; George, A; Salciute, E; Wong, JN; Dunne, K; Flower, L; Sharland, E; Sra, S; Andrew, G; Callaghan, M; Barclay, L; Marshall, L; Amamio, M; Birch, S; Briton, K; Clark, S; Doverman, K; Hope, D; Mcculloch, C; Simpson, S; Singleton, J; Fernandez, R; Allen, M; Baptista, D; Crowe, R; Fox, J; Khera, J; Loveridge, A; McKenley, I; Morino, E; Naranjo, A; O'Connor, D; Simms, R; Sollesta, K; Swain, A; Venkatesh, H; Herdman-Grant, R; Joseph, A; Nown, A; Rose, S; Pogson, D; Boxall, H; Brimfield, L; Claridge, H; Daly, Z; George, S; Gribbin, A; Cheema, Y; Cutler, S; Richards, O; Roynon-Reed, A; Cherian, S; Heron, AE; Williams, G; Szakmany, T; Waters, A; Collins, K; Dunhill, J; Jones, F; Morris, R; Ship, L; Cardwell, A; Ali, S; Bhatterjee, R; Bolton, R; Chukkambotla, S; Coleman, D; Dalziel, J; Dykes, J; Fine, C; Gay, B; Goddard, W; Goodchild, D; Harling, R; Hijazi, M; Keith, S; Khan, M; Matt, R; Ryan-Smith, J; Saad, S; Springle, P; Thomas, J; Truman, N; Kazi, A; Smith, M; Collier, H; Davison, C; Duberley, S; Hargreaves, J; Hartley, J; Patel, T; Smith, E; Kent, A; Goodwin, E; Zaki, A; Tibke, C; Hopkins, S; Gerrard, H; Jackson, M; Bennett, S; Marsh, L; Mills, R; Bell, J; Campbell, H; Dawson, A; Dodds, S; Duffy, S; Gallagher, L; McCafferty, G; Short, S; Smith, T; Thomas, K; Walker, C; Reynolds, J; Yates, B; Mckie, H; Panteli, M; Thompson, M; Waddell, G; De Beger, S; Abraheem, A; Dunmore, C; Girach, R; Jones, R; London, E; Nagra, I; Nasir, F; Sainsbury, H; Smedley, C; Brearey, S; Burchett, C; Cawley, K; Faulkner, M; Jeffrey, H; Bamford, P; Shaikh, F; Slack, L; Davies, A; Brooke, H; Suarez, JC; Charlesworth, R; Hansson, K; Norris, J; Poole, A; Sandhu, R; Smithson, E; Thirumaran, M; Wagstaff, V; Buckley, S; Sloan, B; Rose, A; Major, A; Metcalfe, A; Almaden-Boyle, C; Austin, P; Chapman, S; Eros, A; Cabrelli, L; Cole, S; Whyte, C; Casey, M; Bafitis, V; Tsinaslanidis, G; George, C; Khade, R; Black, C; Ashok, SR; Farley, S; Brinkworth, E; Harford, R; Murphy, C; Williams, M; Newey, L; Toghill, H; Lewis, S; Rees, T; Battle, C; Baker, M; Travers, J; Chesters, K; Baxter, N; Arnott, A; McCreath, G; McParland, C; Rooney, L; Sim, M; Henderson, S; Abel, L; Dalton, C; Kennedy-Hay, S; O'Donohoe, L; O'Hare, M; Orlikowska, I; Parker, N; McNeela, F; Lyle, A; Hughes, A; Radhakrishnan, J; Gibson, S; Bancroft, H; Bellamy, M; Daglish, J; Kadiri, S; Moore, F; Rhodes, J; Sangombe, M; Peterkin, Z; Scriven, J; Carmody, M; Cottle, J; Peasgood, E; de Gordoa, LOR; Phillips, C; Skinner, D; Cinquina, Z; Howard, K; Joy, R; Roche, S; Birkinshaw, I; Carter, J; Ingham, J; Marshall, N; Pearson, H; Scott, Z; Dasgin, J; Gill, J; Nilsson, A; Bamford, A; Hull, D; Ahmadhaider, N; Bates, M; McGhee, C; Ellis, H; Howe, GS; Singh, J; Stroud, N; Roche, L; Lynch, C; Deacon, B; Pothecary, C; Smeaton, J; Agravante, K; Krishnamurthy, V; Diaba, C; John, L; Lim, L; Jha, R; Egan, J; Felton, T; Glasgow, S; Padden, G; Choudhr, O; Bradley-Potts, J; Moss, S; Lingeswaran, S; Alexander, P; Brandwood, C; Fiouni, S; Ward, L; Allen, S; Shaw, J; Smith, C; Adanini, O; Collins, R; Msiska, M; Ofori, L; Bhatia, N; Dolan, H; Brunton, M; Caterson, J; Coles, H; Keating, L; Tilney, E; Jacques, N; Frise, M; Armistead, J; Bartley, S; Bhuie, P; Rai, S; Tomkova, G; Greer, S; Shuker, K; Tridente, A; Dobson, E; Hunt, J; Tully, R; Dearden, J; Drummond, A; Kamath, P; Bullock, E; Mulcahy, M; Munt, S; O'Connor, G; Philbin, J; Rishton, C; Scott, C; Winnard, S; Hasni, N; Gascoyne, R; Hawes, J; Pritchard, K; Stevenson, L; Whileman, A; Beavis, S; Bishop, L; Cart, C; Dale, K; Kelly-Baxter, M; Mendelski, A; Moakes, E; Smith, R; Woodward, J; Wright, S; Allan, A; Botello, A; Liew, J; Medhora, J; Trumper, E; Savage, F; Scott, T; Place, M; Kaye, C; Benyon, S; Marriott, S; Park, L; Quinn, H; Skyes, D; Zitter, L; Baines, K; Gordon, E; Keenan, S; Pitt, A; Duffy, K; Ireland, J; Semple, G; Turner, L; Cathcart, S; Rimmer, D; Puxty, A; Puxty, K; Hurst, A; Miller, J; Speirs, S; Walker, L; Bradshaw, Z; Brown, J; Melling, S; Preston, S; Slawson, N; Warden, S; Beasley, A; Stoddard, E; Benham, L; Cupitt, J; Caswell, M; Elawamy, L; Wignall, A; Roberts, B; Golding, H; Leggett, S; Male, M; Marani, M; Prager, K; Williams, T; Golder, K; Jones, O; Cusack, R; Bolger, C; Burnish, R; Carter, M; Jackson, S; Salmon, K; Biss, J; Aquino, M; Croft, M; Frost, V; White, I; Govender, K; Webb, N; Stapleton, L; Wells, C; Nikitas, N; Sanchez-Rodriguez, A; Spencer, K; Stowe, B; Izzard, Y; Poole, M; Monnery, S; Trotman, S; Beech, V; Combes, E; Joefield, T; Covernton, P; Savage, S; Woodward, E; Camsooksai, J; Reschreiter, H; Barclay, C; Death, Y; Dube, J; Humphrey, C; Jenkins, S; Langridge, E; Milne, R; Wadams, B; Woolcock, M; Brett, M; Digby, B; Gemmell, L; Hornsby, J; MacGoey, P; O'Neil, P; Price, R; Sundaram, R; Rodden, N; Thomson, N; Rooney, K; Currie, S; Henderson, P; Ogg, B; Whiteley, S; Wilby, L; Long, K; Matthew, S; Salada, S; Trott, S; Watts, S; Friar, Z; Speight, A; Bastion, V; Chandna, H; Djeugam, B; Haseeb, M; Kent, H; Lubimbi, G; Murdoch, S; Thomas, A; David, B; Lorusso, R; Vochin, A; Penacerrada, M; Wulandari, R; Heath, C; Jakkula, S; Morris, A; Ahmed, A; Nune, A; Buttriss, C; Whitaker, E; Davey, M; Golden, D; Acklery, A; Fernandes, F; Seaman, B; Earl, V; Collins, A; Khaliq, W; Adam, R; Treus, E; Holland, S; Alfonso, J; Blackledge, B; Bruce, M; Durrans, LJ; Eltayeb, A; Harris, J; Hey, S; Hruska, M; Lamb, T; Rothwell, J; Fitzgerald, A; Lindergard, G; T-Michael, H; Duncan, T; Baxter-Dore, S; Cooper, L; Fox, C; Guerin, J; Hodgkiss, T; Connolly, K; McAlinden, P; Bridgett, V; Fearby, M; Gulati, A; Hanson, H; Kelly, S; McCormack, L; Nixon, R; Robinson, P; Slater, V; Stephenson, E; Webster, A; Webster, K; Hays, C; Hudson, A; Patel, B; Clement, I; Davis, J; Francis, S; Jerry, D; Abernathy, C; Foster, L; Gratrix, A; Cabral-Ortega, L; Hines, M; Martinson, V; Stones, E; Winter, K; Barrow, E; Wylie, K; Baines, D; Birchall, K; Kolakaluri, L; Clark, R; Sukumaran, A; Barker, M; Paripoorani, D; Smith, L; Taylor, C; Downes, C; Hayman, M; Riches, K; Daniel, P; Subramanian, D; Holding, K; Hilton, M; Mcdonald, C; Richardson, G; Halladay, G; Harding, P; Reddy, A; Turner-Bone, I; Wilding, L; Parker, R; Lloyd, M; Smith, L; Kelly, C; Lazo, M; Neal, A; Walton, O; Melville, J; Naisbitt, J; Joseph, R; Callam, S; Hudig, L; Keshet-Price, J; Stammers, K; Convery, K; Randell, G; Fottrell-Gould, D; Mwaura, E; Sutherland, SB; Stewart, R; Mew, L; Wren, L; Thrasyvoulou, L; Willis, H; Hopkins, B; Lenton, D; Roberts, A; Bokhari, M; Lucas, R; McCormick, W; Ritzema, J; Linnett, V; Sanderson, A; Wild, H; Flanagan, R; Hull, R; Rhead, K; McKenna, E; Hughes, G; Anderson, J; Jones, K; Latham, S; Riley, H; Coulding, M; Clark, M; McCormick, J; Mercer, O; Potla, D; Rehman, H; Savill, H; Turner, V; Jude, E; Kilroy, S; Apetri, E; Basikolo, C; Catlow, L; Collis, M; Doonan, R; Harvey, A; Knowles, K; Lee, S; Lomas, D; Lyons, C; McMorrow, L; Michael, A; Pendlebury, J; Perez, J; Poulaka, M; Proudfoot, N; Slevin, K; Thomas, V; Walker, D; Dark, P; Charles, B; McLaughlan, D; Slaughter, M; Horner, D; Cawley, K; Marsden, T; Andrews, J; Beech, E; Akinkugbe, O; Bamford, A; Belfield, H; Jones, GAL; McHugh, T; Meghari, H; Ray, S; Tomas, AL; O'Neill, L; Peters, M; Bell, M; Benkenstein, S; Chisholm, C; Davies, C; Kupiec, K; Payne, C; Halls, J; Blakemore, H; Goff, E; Hayes, K; Smith, K; Stephens, D; Worner, R; Borislavova, B; Faulkner, B; Thomas, M; Cookson, R; Gendall, E; Larman, G; Pope, R; Smalira, A; Priestley, V; Cosier, T; Millen, G; Rand, J; Schumacher, N; Sandhar, R; Weston, H; Richardson, N; Cooper, L; Jones, C; Huang, YWJ; Jacob, R; Denmade, C; Mcintyre, L; Trodd, D; Martin, J; Watson, G; Bevan, E; Wreybrown, C; Bano, S; Bellwood, R; Bentley, M; Bromley, M; Gurr, L; Ledgard, C; McGowan, J; Pye, K; Sellick, K; Stacey, A; Warren, D; Wilkinson, B; Akeroyd, L; Shafique, H; Morgan, J; Shorter, S; Swinger, R; Waters, E; Lawton, T; Allan, E; Darlington, K; Davies, F; Davies, L; Easton, J; Kumar, S; Lean, R; Mackay, C; Pugh, R; Qiu, XY; Rees, S; Scanlon, J; Lewis, J; Menzies, D; Bolger, A; Davies, G; Davies, J; Garrod, E; Jones, H; Manley, R; Williams, H; Frankham, J; Pitts, S; White, N; Branney, D; Tiller, H; Efford, G; Garland, Z; Grimmer, L; Gumbrill, B; Johnson, R; Sweet, K; Bewley, J; Coleman, C; Corcoran, K; Morano, EMH; Shiel, R; Webster, D; Bonnici, J; Daniel, E; Dell, A; Kent, M; Wilkinson, A; Brown, E; Kay, A; Campbell, S; Cowton, A; Birt, M; Greenaway, V; Potts, K; Hutton, C; Shepperson, A; Forsey, M; Nicholson, A; Vertue, M; Riches, J; Kaliappan, A; Nicholson, A; MacCallum, N; Raith, E; Bercades, G; Hass, I; Brealey, D; Martir, G; Reyes, A; Smyth, D; Zapatamartinez, M; Alvaro, A; Jetha, C; Ma, L; Booker, L; Mostoles, L; Pratley, A; Altabaibeh, A; Parmar, C; Gilbert, K; Ferguson, S; Shepherd, A; Morris, S; Baruah, R; Lloyd, G; Bell, S; Rivers, V; Purewal, B; Hammerton, K; Anderson, S; Birch, J; Collins, E; Oleary, R; Cornell, S; Jarmain, J; Rogerson, K; Wakinshaw, F; Woods, L; Rostron, A; Elcioglu, Z; Roy, A; Bell, G; Dickson, H; Wilcox, L; Katary, A; English, K; Hutter, J; Pawley, C; Doble, P; Shovelton, C; Vaida, M; Purnell, R; Thomas, A; Cagova, L; Fofano, A; Holcombe, H; Mitchell, AM; Mwaura, L; Praman, K; Garnr, L; Mepham, S; Paques, K; Vuylsteke, A; Mackie, J; Pearn, C; Zamikula, J; Nyirenda, M; Capozzi, L; Reece-Anthony, R; Noor, H; Nilo, AC; Grove, M; Daniel, A; Finn, J; White, N; Saha, R; Badal, B; Ixer, K; Duffin, D; Player, B; Hill, H; Cole, J; Brooks, J; Davies, M; Davies, R; Hunt, L; Thomas, E; Williams, A; Oblak, M; Thankachen, M; Irisari, J; Sayan, A; Popescu, M; Finch, C; Jamieson, A; Quinn, A; Cooper, J; Liderth, S; Waddington, N; Burn, I; Manso, K; Penn, R; Tebbutt, J; Thornton, D; Winchester, J; Hambrook, G; Shanmugasundaram, P; Craig, J; Simpson, K; Higham, A; Sibbett, L; Paine, S; Reed, A; Conyngham, JA; Mupudzi, M; Thomas, R; Wright, M; Griffin, D; Partridge, R; Corral, MA; Muchenje, N; Sitonik, M; Butler, A; Folkes, L; Fox, H; Gardner, A; Helm, D; Hobden, G; King, K; Margalef, J; Margarson, M; Martindale, T; Meadows, E; Raynard, D; Thirlwall, Y; Baird, Y; Gomez, R; Martin, D; Hodgson, L; Corin, C; Sidall, E; Szabo, D; Floyd, S; Davies, H; Austin, K; Kelsall, O; Wood, H; Cornell, T; Ralph, K; Bean, S; Burt, K; Spivey, M; Richards, C; Tedstone, R; Carmody, S; Zhao, XB; Page, V; Guanco, ML; Hoxha, E; Zorloni, C; Dean, C; Jones, E; Carter, E; Dunn, J; Kong, T; Mahenthran, M; Marsh, C; Holland, M; Keenan, N; Mahmoud, M; Lyons, M; Bradley-Potts, J; Wassall, H; Young, M; Bradley, P; Burda, D; Donlon, S; Harden, L; Harris, C; Mayangao, I; Montaser, R; Mtuwa, S; Piercy, C; Smith, E; Stone, S; Verula, J; Blackman, H; Marriott, C; Michalak, N; Creagh-Brown, B; Salberg, A; Boyer, N; Pristopan, V; Maynard, V; Walker, R; Hormis, A; Collier, D; Graham, C; McCormick, J; Warrington, J; Cosgrove, D; McFarland, D; Ratcliffe, J; Charnock, R; Wynter, I; Gill, M; Kirk, J; Paul, P; Ratnam, V; Shelton, S; Jardine, C; Hay, A; Williams, D; Durga, L; Hibbert, M; Kennard-Holden, G; Woodford, C; Tetla, D; Price, A; Thomas, A; Thorpe, C; Knights, E; Ward, D; Laha, S; Verlander, M; Williams, A; Prout, R; Langton, H; Watters, M; Hunt, C; Novis, C; Arif, S; Cunningham, A; Hewitt, C; Hindale, J; Jackson-Lawrence, K; Shepardson, S; Wills, M; Butler, S; Tavares, S; Barber, R; Hilldrith, A; Hubbard, K; Egginton, D; Clark, M; Purvis, S; Sinclair, S; Collins, V; Landeg, B; Sell, C; Coetzee, S; Gales, A; Otahal, I; Icke, B; Raj, M; Williams, C; Williams, J; Hill, L; Kayani, A; Masunda, B; Gondo, P; Atayeva, N; Cruz, C; Pattison, N; Burnett, C; Hatton, J; Heeney, E; Newton, M; Al-Moasseb, H; Behan, T; Player, J; Stead, R; Mitra, A; Nauyokas, K; Humphreys, S; Cockerill, H; Tampsett, R; Postovalova, E; Coventry, T; McGregor, A; Fowler, S; Macmahon, M; Cochrane, P; Pirie, S; Hanley, S; Ali, A; Brady, M; Dale, S; Dance, A; Gledhill, L; Greig, J; Hanson, K; Holdroyd, K; Home, M; Ishaq, T; Kelly, D; Matapure, L; Melia, D; Mellor, S; Merwaha, E; Nortcliffe, T; Shaw, L; Shaw, R; Wood, T; Bayo, LA; Usher, M; Wilson, A; Kitson, R; Pinnell, J; Robinson, M; Boltwood, K; Birch, J; Bough, L; Tutton, R; Winter-Goodwin, B; Goodsell, J; Taylor, K; Williams, P; Williams, S; Cave, A; Rees, J; Imeson-Wood, J; Smith, J; Amin, V; Karthik, K; Kausar, R; Anastasescu, E; Reid, K; Anumakonda, V; Stoddart, E; Demetriou, C; Eckbad, C; Howie, L; Mitchard, S; Ramos, L; White, K; Hierons, S; Kelly, F; Serrano-Ruiz, A; Evans, G; Nicol, L; Wilkins, J; Hulacka, K; Debreceni, G; Brown, A; Crickmore, V; Hill, K; Kannan, T; Dagutao, Z; Beesley, K; Lewis, A; Perry, J; Antony, S; Board, S; Buckley, C; Pippard, L; Tanate, A; Wood, D; Kubisz-Pudelko, A; Gouda, A; Auld, F; Donnachie, J; Murdoch, E; Prentice, L; Runciman, N; Senaratne, D; Short, A; Sweeney, L; Symon, L; Todd, A; Turner, P; McCann, E; Salutous, D; Edmond, I; Whitelaw, L; Bland, Y; Kajtor, I; Kavanagh, L; Singler, K; Linfield-Brown, G; Moore, LSP; Vizcaychipi, M; Martins, L; Moore, L; Bull, R; Carungcong, J; Allen, L; Beranova, E; Knight, A; Price, C; Tilbey, S; Turney, S; Hazelton, T; Tutt, G; Arora, M; Turki, S; Sinfield, E; Deery, J; Ramos, H; Cristiano, D; Dormand, N; Farzad, Z; Gummadi, M; Salmi, S; Sloane, G; Varghese, M; Thwaites, V; Patel, B; Kamal, L; Zborowski, AC; Coe, R; Anderson, M; Beadle, J; Coates, C; Collins, K; Crowley, M; Johnson, L; King, L; Paramsothy, R; Sargeant, J; Silva, P; Stuart, C; Taylor, J; Tyl, D; Wakefield, P; Kamundi, C; Olufuwa, O; Belagodu, Z; Gherman, A; Oakley, N; Allan, J; Geary, T; Meikle, A; O'Brien, P; Wood, S; Clark, A; Houston, G; Black, K; Clarkson, M; D'Sylva, S; Morrison, A; Norman, K; Taylor, M; Clements, S; Cohrane, C; Gonzalez, N; Strachan, D; Beith, C; Moar, K; Anderson, P; Archer, K; Burtenshaw, A; Clayton, S; Cother, N; Cowley, N; Davis, C; Digby, S; Durie, A; Harrison, A; Low, E; McAlindon, M; McCurdy, A; Morgan, A; Rankin, T; Thrush, J; Tranter, H; Vigurs, C; Wild, L; Murphy, L; Smythe, M; Brickell, K; Ali, IAM; Beaumont, K; Elsaadany, M; Fernandes, K; Ally, SM; Rangarajan, H; Sarathy, V; Selvanayagam, S; Vedage, D; White, M; Coton, Z; Joshy, A; Blunt, M; Curgenven, H; Botfield, L; Dexter, C; Kuravi, A; Butler, J; Chadwick, R; Ranga, P; Richardson, L; Virgilio, E; Anwer, M; Garg, A; Botfield, D; Marriott, X; Stewart, K; Mullan, D; Gaylard, J; Nowak, J; Jones, S; Crawley, R; Crew, A; Cunningham, M; Daniels, A; Harrison, L; Hope, S; Lancaster, N; Matthews, J; Wray, G; Inweregbu, K; Cutts, S; Miller, K; Brady, A; Chan, R; McIvor, S; Prady, H; Mathew, B; Little, J; Furniss, T; Wright, C; King, B; Wasson, C; O'Neill, A; Turley, C; McGuigan, P; Collins, E; Finn, S; Green, J; McAuley, J; Nair, A; Quinn, C; Tauro, S; Ward, K; McGinlay, M; Reddy, K; Ahmad, N; Anderson, S; Barker, J; Bauchmuller, K; Birchall, K; Bird, S; Cawthron, K; Chetam, L; Cole, J; Donne, B; Foote, D; Ford, A; Hanratty, H; Harrington, K; Hesseldon, L; Housley, K; Jackson, Y; Jarman, C; Kibutu, F; Lenagh, B; Macharia, I; Masuko, S; Milner, L; Newell, H; Nwafor, L; Oxspring, S; Phillips, P; Raithatha, A; Rowland-Jones, S; Smith, J; Thompson, R; Trower, H; Walker, S; Watson, J; Wiles, M; Lye, A; Willson, J; Mills, G; Harris, S; Hartill, E; Barron, A; Collins, C; Kaul, S; Nolan, C; Polgar, O; Prendergast, C; Rogers, P; Shokkar, R; Woodruff, M; Mahay, K; Reed, A; Meyrick, H; Passmore, H; Farwell, J; O'Connell, S; Gregory, J; Barberis, L; Harper, R; Smith, T; Armstrong, D; Bowey, A; Cowley, A; Corner, A; Highgate, J; Rutherfurd, C; Taylor, JA; Goodwin, S; Eapen, B; Trim, F; Donnison, P; Armstrong, L; Bates, H; Dooks, E; Farquhar, F; Kitching, A; McParland, C; Packham, S; Hairsine, B; Andreou, P; Hales, D; Mathews, M; Patel, R; Barry, P; Flint, N; Hailstone, J; Ghuman, N; Leonard, B; Lees, R; Butcher, D; Leng, K; Butterworth-Cowin, N; O'Sullivan, S; Ghosh, A; Williams, E; Adams, C; Agasou, A; Arden, T; Beekes, M; Bowes, A; Boyle, P; Button, H; Carnahan, M; Carter, A; Childs, D; Hurford, F; Hussain, Y; Javaid, A; Jones, J; Leigh, M; Martin, T; Millward, H; Motherwell, N; Newman, J; Rikunenko, R; Stickley, J; Summers, J; Ting, L; Tivenan, H; Donaldson, D; Capps, N; Cale, E; Jose, S; Osbourne, W; Pajak, S; Rankin, J; Tonks, L; Baird, T; Harkins, M; Ruddy, J; West, J; Duffield, J; Mallon, L; Smith, O; Smuts, S; Campbell, A; Davies, C; Davies, S; Hughes, R; Jobes, L; Whitehead, V; Watkins, C; Bowman, F; Milligan, B; McPherson, L; Metherell, S; Harris, N; Lake, V; Radford, E; Smallwood, A; Gopal, S; Vassell, K; Bell, D; Boyle, R; Douglas, K; Glass, L; Lennon, L; Rattray, A; Lee, E; Jones, D; Parsons, P; Attwood, B; Jefferson, P; Ranganathan, M; Atwal, I; Campbell, B; Day, A; Stagg, C; Haynes, E; Ahmed, C; Clamp, S; Colley, J; Haq, R; Hayes, A; Joseph, S; Maqsood, Z; Hussain, S; Hulme, J; Domingos, P; Kumar, R; Purewal, M; Taylor, B; Bunni, L; Latif, M; Jennings, C; Jose, S; Marshall, R; Metryka, A; Subramanian, G; Burgoyne, A; Tyler, A; Waldron, J; Hilltout, P; Evitts, J; Ward, G; Bremmer, P; Hawkins, C; Jackman, S; Ogorek, M; Ashby, K; Thornton, L; Mercer, P; Halkes, M; Revill, A; Saint, B; Fletcher, J; Netherton, K; Chablani, M; Kirkby, A; Roper, A; Szymiczek, K; Sutherland, I; O'Brien, L; Connell, J; Davies, K; Lewis, T; Omar, Z; Perkins, E; Sathe, S; Davies, E; Lyon, A; Mapfunde, I; Willis, C; Hitchcock, R; Hall, K; King, C; Fagan, A; Nazari, R; Worsley, L; Allibone, S; Kasipandian, V; Patel, A; Cutting, P; Genetu, R; Mac, A; Murphy, A; Ward, S; Butt, F; Ayers, A; Harrison, W; Mackintosh, K; North, J; Ashton, L; Bi, R; Owen, S; Winmill, H; Scholefield, B; Blowing, H; Williams, E; Duskova, M; Edwards, M; Rees, A; Thomas, H; Hughes, R; Brooks, J; Phipps, J; Brooks, S; Dennis, C; Parris, V; Srikaran, S; Sukha, A; McGregor, A; Tiongson, G; Adams, K; Andrew, B; Brayne, A; Carter, S; Findlay, L; Fisher, E; Jackson, P; Kaye, D; Parkin, J; Tuckey, V; Hunt, J; Love, N; van Koutrick, L; Hanson, A; Dent, K; Horsley, E; Pearson, S; Spencer, S; Hutchinson, D; Potoczna, D; Akhtar, MN; Cottam, LJ; Sanders, J; Garcia, SM; Pakou, G; Filipe, H; Maharajh, A; de Neef, M; Martin, D; Eastgate, C; Teoh, PC; Barrett, F; Bradley, C; Donaldson, A; Mascarenhas, M; O'Hara, M; Okeefe, L; Clarke, N; Whiteside, J; Campbell, R; Matheson, J; McDonald, D; Patience, D; Rice, P; Clapham, M; Mutch, R; Craig, H; Poultney, U; Burns, K; Twiss, S; Barton, J; George, L; Harrop, C; Mathew, S; Wright, DJ; Harrison, R; Toohie, J; Chandler, B; Turnbull, A; Mallinson, J; Elliott, K; Wolf-Roberts, R; Tench, H; Hobrok, M; Loosley, R; McGuinness, H; Sims, T; Afolabi, D; Allison, KS; Anderson, T; Dore, R; Jones, D; Rogers, N; Saunderson, P; Whitbread, J; O'Malley, L; Rad, L; Hawcutt, D; Aldridge, J; Tolson, M; Garrioch, S; Tomlinson, J; Grosdenier, M; Loader, D; Kapoor, R; Hector, G; Scherewode, J; Sri-Chandana, C; Stephenson, L; Marsh, S; Dela Rosa, A; Jhanji, S; Bemand, T; Howle, R; Baikady, RR; Thomas, B; Black, E; Tatham, K; Gurram, S; Watson, E; Quaid, S; Saunderson, A; O'Brien, R; Moultrie, S; Service, J; Cheyne, C; Odam, M; Wiliams, A; Barnes, N; Csabi, P; Da Rocha, J; Glynou, L; Huffenberger, A; Bryant, J; Pickard, A; Roe, N; Bellini, A; Mayer, A; Burrow, A; Colley, N; Evans, J; Howlett, A; Khalifeh, Z; Pryce, J; Gorman, C; Brady, R; Timlick, E; Antoine, P; Gupta, A; Hardy, J; Houlden, H; Moncur, E; Tucci, A; Tariq, A; Tagliavini, E; Ramsay, B; Fidler, K; Donnelly, K; Hollis, R; Barr, J; Boyd, E; Irvine, V; Shelley, B; Buckley, J; Hamilton, C; Valdeavella, K; Bircham, S; Liggett, S; Patil, A; Siddiq, A; Goddard, P; Donovan, S; Zainy, T; Maleady-Crowe, F; Todd, L; Salehi, S; Elgar, G; Chan, G; Arumugam, P; Patch, C; Rendon, A; Bentley, D; Kingsley, C; Fowler, TA; Elliott, P; Tenesa, A; Aitkin, E; Aravindan, L; Armstrong, R; Biggs, H; Boz, C; Brown, A; Chikowore, P; Clark, R; Coutts, A; Coyle, J; Cullum, L; Das, S; Day, N; Donnelly, L; Duncan, E; Finernan, P; Fourman, MH; Furlong, A; Furniss, J; Gallagher, B; Gilchrist, T; Golightly, A; Hafezi, K; Hamilton, D; Hendry, R; Kearns, N; Law, D; Law, R; Law, S; Lidstone-Scott, R; Lauder, C; Macgillivray, L; Maclean, A; Mal, H; McCafferty, S; Mcmaster, E; Meikle, J; Moore, SC; Murphy, S; Mybaya, H; Odam, M; Oosthuyzen, W; Zheng, CQ; Chen, JT; Paterson, T; Tucker, P; Schon, K; Stenhouse, A; Das, M; Swets, M; Szoor-McElhinney, H; Taneski, F; Turtle, L; Wackett, T; Ward, M; Weaver, J; Wrobel, N; Rakitko, A; Ilinsky, V; Yermakovich, D; Popov, I; Chernitsov, A; Kovalenko, E; Vergasova, E; Prokhorov, A; Krasnenko, A; Plotnikov, N; Stetsenko, I; Kim, A; Cirulli, ET; Barrett, KMS; Bolze, A; White, S; Washington, NL; Lu, JT; Riffle, S; Tanudjaja, F; Wang, XQ; Ramirez, JM ; Leonetti, N; Sandoval, E; Neveux, I; Dabe, S; Grzymski, JJ; Joshi, MN; Dixit, RD; Shah, PK; Upadhyay, KJ; Chuhan, NT; Desai, KJ; Shah, MR; Modi, B; Joshi, CG; Pandit, RJ; Singh, I; Ansari, AI; Raval, JN; Patel, ZZ; Moreno-Estrada, A; Vázquez-Pérez, JA; Castillejos-López, M; Aquino-Gálvez, A; Shamah-Levy, T; Avila-Arcos, MC; Luna, MTT; Hidalgo-Miranda, A; Barberena-Jonas, C; Quinto-Cortés, CD; Avila-Arcos, MA; Huerta-Chagoya, A; García-García, L; Barnetche, JM; Alpuche-Aranda, C; Rivera, JA; Gutiérrez, TB; Ochoa-Guzmán, A; Ordoñez-Sánchez, ML; Segura-Kato, Y; Herrera-Montalvo, LA; Mendoza-Vargas, A; Reyes-Grajeda, JP; Cruz-Cruz, AD; Velázquez-Cruz, R; Torres-Espíndola, LM; Sierra-Vargas, MP; Camarena, A; Ruiz, V; Chávez-Alderete, J; Jaime-Capetillo, ME; Guadarrama-Pérez, C; Zúñiga-Ramos, J; Olivera-Ramírez, A; Martínez, MAL; Serna-Muñoz, R; Garmendia, A; Namkoong, H; Okada, Y; Imoto, S; Katayama, K; Fukunaga, K; Kitagawa, Y; Sato, T; Hasegawa, N; Kumanogoh, A; Kimura, A; Ai, M; Tokunaga, K; Kanai, T; Miyano, S; Ogawa, S; Edahiro, R; Sonehara, K; Shirai, Y; Kanai, M; Ishii, M; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Tanaka, H; Morita, A; Lee, H; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Mikami, Y; Tomono, K; Kato, K; Matsuda, F; Takahashi, M; Hizawa, N; Takeda, Y; Hirata, H; Shiroyama, T; Miyawaki, S; Suzuki, K; Maeda, Y; Nii, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Takahashi, K; Anzai, T; Hasegawa, T; Ito, S; Koike, R; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, C; Nakajima, J; Nannya, Y; Omae, Y; Takahashi, K; Harada, N; Hiki, M; Takagi, H; Nakamura, A; Tagaya, E; Kawana, M; Arimura, K; Ishiguro, T; Takayanagi, N; Isono, T; Takaku, Y; Takano, K; Anan, R; Nakajima, Y; Nakano, Y; Nishio, K; Ueda, S; Hayashi, R; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Mitamura, K; Saito, F; Ueda, T; Azuma, M; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Yoshiyama, T; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Watanabe, K; Manabe, T; Ito, F; Fukui, T; Funatsu, Y; Koh, H; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Saito, F; Yoshiya, K; Yoshihara, T; Suzuki, Y; Nakayama, S; Masuzawa, K; Nishi, K; Nishitsuji, M; Tani, M; Inoue, T; Hirano, T; Kobayashi, K; Miyazawa, N; Kimura, Y; Sado, R; Ogura, T; Kitamura, H; Murohashi, K; Nakachi, I; Baba, R; Arai, D; Fuke, S; Saito, H; Kuwahara, N; Fujiwara, A; Okada, T; Baba, T; Noda, J; Mashimo, S; Yagi, K; Shiomi, T; Hashiguchi, M; Odani, T; Mochimaru, T; Oyamada, Y; Mori, N; Izumi, N; Nagata, K; Taki, R; Murakami, K; Yamada, M; Sugiura, H; Hayashi, K; Shimizu, T; Gon, Y; Fujitani, S; Tsuchida, T; Yoshida, T; Kagaya, T; Kita, T; Sakagami, S; Kimizuka, Y; Kawana, A; Nakamura, Y; Ishikura, H; Takata, T; Kikuchi, T; Taniyama, D; Nakamura, M; Kodama, N; Kaneyama, Y; Maeda, S; Nagasaki, Y; Okamoto, M; Ishihara, S; Ito, A; Chihara, Y; Takeuchi, M; Onoi, K; Hashimoto, N; Wakahara, K; Ando, A; Masuda, M; Wakabayashi, A; Watanabe, H; Sageshima, H; Nakada, TA; Abe, R; Shimada, T; Kawamura, K; Ichikado, K; Nishiyama, K; Yamasaki, M; Hashimoto, S; Kusaka, Y; Ohba, T; Isogai, S; Takada, M; Kanda, H; Komase, Y; Sano, F; Asano, K; Oguma, T; Harada, M; Takahashi, T; Shibusawa, T; Abe, S; Kono, Y; Togashi, Y; Izumo, T; Inomata, M; Awano, N; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Kitagawa, Y; Yoshida, S; Ogura, S; Nishiyama, K; Yoshida, K; Beppu, S; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Inoue, Y; Yamagata, K; Chiba, S; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Sagara, H; Tanaka, A; Ohta, S; Shibata, Y; Tanino, Y; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Imamura, T; Umeda, A; Shimada, H; Endo, M; Hayashi, S; Takahashi, M; Nakano, S; Yatomi, M; Maeno, T; Ishii, T; Utsugi, M; Ono, A; Kanaoka, K; Ihara, S; Komuta, K; Tokunaga, K; Nishida, N; Kawai, Y; Sugiyama, M; Alawneh, LM; Maswadeh, KB; Alsoub, FS; AlRawashdeh, TJ; Esawi, E; Abu Alragheb, BO; Maswadeh, AB; Al-Kadash, A; Al-Ani, A; Alsafadi, DB; Shahin, MA; Al Qtaish, N; Alawneh, FM; Abulail, JA; Zhlawi, HJ; Alhousani, TN; Alzuraiqi, MR; Al-Ja'afreh, MM; Allouzy, SK; ALjalamdeh, M; Mansour, TM; Alamer, LM; Issa, AB; Younis, FMB; Hawari, FI; Hayajneh, WA; Obeidat, NM; Ahram, M; Zhlawi, MWJ; Alshaer, W; Al-Kasasbeh, MM; Naffa, RG; Ismail, MA; Abdullah, MS; Ismail, SI; Obeidat, M; Cordero, AIH; Sin, DD; Bossé, Y; Joubert, P; Hao, K; Nickle, D; Timens, W; van den Berge, M; Feng, YCA; Mercader, J; Weiss, ST; Karlson, EW; Smoller, JW; Murphy, SN; Meigs, JB; Woolley, AE; Green, RC; Mandla, R; Schroeder, P; Perez, EF; Lee, SHT; Flores-Silva, FD; Chiquete, E; Cantú-Brito, C; Sifuentes-Osornio, J; de León-Garduño, AP; Román-Montes, CM; Chávez-Manzanera, E; Velasco, DG; Martagón-Rosado, A; Cruz-Bautista, I; Gómez-Pérez, FJ; Diaz-Olavarrieta, C; Valdés, PA; Muñóz-Hernández, LL; Mehta, RP; Elías-López, D; Tusié-Luna, T; Pajukanta, P; Sukhatme, MG; Moreno-Macías, H; Huerta-Chagoya, A; Ruth, J; Ochoa-Guzmán, A; González-Behn-Eschenburg, S; García-Grimshaw, M; Guillen-Pineda, LE; Vargas-Martínez, MD; Rodríguez, M; Rodríguez-Guillén, R; Ordoñez, ML; Segura-Kato, Y; Rajme-López, S; González-Lara, MF; Luna-Moreno, D; López, JDS; Guillén-Quintero, DM; Vega, J; Duran-Coyote, S; Guerra-García, MT; Durán-Gómez, M; Vigueras-Hernández, A; Ramírez-Jiménez, ME; Grajeda-González, SL; Ramos-Galicia, EM; Ramirez-Carrillo, MF; Fernandez-Ruiz, J; Chirino-Perez, A; Romero-Molina, AO; Zavaleta, DAF; Jaramillo, MAM; Lopez, KJP; Incontri-Abraham, D; Rosado, WN; Catalan, MA; Aguilar, SEV; Zamudio, IPM; Ruiz-Ruiz, E; Garcia, KDC; Guerrero, CV; Martinez, AIR; Moscoso-Sanchez, R; Mancilla, MDR; Villa, A; Luna-Ramirez, SA; Hernández-Hernández, S; Frias, E; Campos, A; Morales-Sosa, PA; Toxqui-Merchant, LE; García, K; Pasaniuc, B; Butte, MJ; Geschwind, DH; Aguilar-Salinas, CA; Heidecker, B; Kurth, F; Sander, LE; Skurk, C; Landmesser, U; Karadeniz, Z; Wang, XM; Poller, W; Suwalski, P; Ripke, S; Braun, A; Kraft, J; Mayer, A; Lippert, LJ; Helbig, ET; Thibeault, C; Awasthi, S; Mbarek, H; Ismail, SI; Saad, C; Al-Sarraj, Y; Badji, RM; Al-Muftah, W; Al Thani, A; Afifi, N; Sadiq, F; Khan, MI; Bhutta, MJ; Khan, H; Khan, M; Ain, Q; Junaid, A; Khan, EA; Sypniewski, M; Lejman, A; Zawadzki, P; Kaja, E; Sztromwasser, P; Król, Z; Dobosz, P; Stojak, J; Flores, C; Carracedo, A; Aguilar, C; Arana-Arri, E; Arranz, MJ; Baptista-Rosas, RC; Bezerra, JF; Bezerra, MAC; Brugada, R; Bustos, M; Calderón, EJ; Castano, L; Conde-Vicente, R; Cordero-Lorenzana, ML; De Martino-Rodríguez, A; Domínguez-Garrido, E; Fariñas, MC; Gil-Fournier, B; Herrero, MJ; Lattig, MC; Martin-López, C; Martín, V; Martinez-Nieto, O; Martinez-Lopez, I; Mazzeu, JF; Macías, EM; Cuerda, VM; Silbiger, VN; Oliveira, SF; Parellada, M; Santos, NPC; Pérez-Matute, P; Perez, P; Perucho, T; Porras-Hurtado, GL; Pujol, A; Fernández-Rodríguez, A; Jimenez-Sousa, MA; Rodríguez-Ruiz, E; Rodriguez-Artalejo, F; Rodriguez-Garcia, JA; Ruiz-Cabello, F; Soria, JM; Tamayo, E; Teper, A; Torres-Tobar, L; Urioste, M; Yáñez, Z; Zarate, R; Guillen-Navarro, E; Ayuso, C; González-Neira, A; Riancho, JA; Rojas-Martinez, A; Lapunzina, P; Cruz, R; Diz-de Almeida, S; Ceballos, FC; Lorenzo-Salazar, JM; González-Montelongo, R; Quintela, I; Pita, G; Gago-Domínguez, M; Porras, MS; Tenorio-Castaño, JA; Nevado, J; Aguado, JM; Aguilera-Albesa, S; Almadana, V; Almoguera, B; Alvarez, N; Andreu-Bernabeu, A; Arango, C; Artiga, MJ; Barreda-Sánchez, M; Belhassen-Garcia, M; Boix-Palop, L; Brion, M; Carbonell, C; Castelao, JE; Cortes-Sanchez, JL; Corton, M; Darnaude, MT; del Campo-Pérez, V; de Bustamante, AD; Luchessi, AD; Eiros, R; Sanabria, GME; Fernández-Robelo, U; Fernández-Villa, T; Gómez-Arrue, J; Alvarez, BG; de Quiros, FGB; González-Peñas, J; Gutiérrez-Bautista, JF; Herrero-Gonzalez, A; Borja, AL; Lopez-Rodriguez, R; Mancebo, E; Martinez-Resendez, MF; Martinez-Perez, A; Minguez, P; Ortega-Paino, E; Paz-Artal, E; Pérez-Tomás, ME; Pinsach-Abuin, M; Pompa-Mera, EN; León, SR; Resino, S; Fernandes, MR; Ruiz-Hornillos, J; Ryan, P; Souto, JC; Tamayo-Velasco, A; Taracido-Fernandez, JC; Valencia-Ramos, J; de Heredia, ML; Pedersen, OB; Erikstrup, C; Ostrowski, SR; Banasik, K; Brunak, S; Feenstra, B; Stefansson, K; Mikkelsen, S; Sorensen, E; Ullum, H; Westergaard, D; Burgos, C; Andersen, S; Brugdorf, K; Hansen, TF; Hjalgrim, H; Jemec, GB; Nyegaard, M; Werge, T; Johansson, PI; Didriksen, M; Geller, F; Schwinn, M; Jacobsen, RL; Hindhede, L; Rostgaard, K; Gudbjartsson, D; Stefánsson, H; Thorsteinsdóttir, U; Nielsen, KR; Bruun, MT; Dinh, KM; Larsen, MAH; Sækmose, SG; Niemi, MEK; Zeberg, H; Cordioli, M; Pigazzini, S; Nkambul, L; Frithiof, R; Hultström, M; Lipcsey, M; Tardif, N; Rooyackers, O; Grip, J; Maricic, T; Heid, IM; Wagner, R; Überla, K; Winkler, TW; Wiegrebe, S; Gorski, M; Stark, KJ; Peterhoff, D; Einhauser, S; Niller, HH; Beileke, S; Johnson, R; Pasaniuc, B; Butte, MJ; Freimer, N; Butte, MJ; Geschwind, DH; Pasaniuc, B; Ding, Y; Chiu, A; Chang, TS; Boutros, P; Nakanishi, T; Karczewski, KJ; Martin, AR; Wilson, DJ; Spencer, CCA; Crook, DW; Wyllie, DH; O'Connell, AM; Richards, JB; Butler-Laporte, G; Forgetta, V; Atkinson, EG; Kanai, M; Tsuo, K; Baya, N; Turley, P; Gupta, R; Walters, RK; Palmer, DS; Sarma, G; Solomonson, M; Cheng, N; Lu, WH; Churchhouse, C; Goldstein, JI; King, D; Zhou, W; Seed, C; Daly, MJ; Neale, BM; Finucane, H; Bryant, S; Satterstrom, FK; Band, G; Earle, SG; Lin, SK; Arning, N; Koelling, N; Armstrong, J; Rudkin, JK; Callier, S; Bryant, S; Cusick, C; Fernandez-Cadenas, I; Planas, AM; Perez-Tur, J; Llucià-Carol, L; Cullell, N; Muiño, E; Cárcel-Márquez, J; DeDiego, ML; Iglesias, LL; Soriano, A; Rico, V; Agüero, D; Bedini, JL; Lozano, F; Domingo, C; Robles, V; Ruiz-Jaén, F; Márquez, L; Gomez, J; Coto, E; Albaiceta, GM; García-Clemente, M; Dalmau, D; Arranz, MJ; Dietl, B; Serra-Llovich, A; Soler-Palacin, P; Colobran, R; Martin-Nalda, A; Parra-Martínez, A; Bernardo, D; Rojo, S; Fiz-López, A; Arribas-Rodriguez, E; Cal-Sabater, P; Segura, T; González-Villar, E; Serrano-Heras, G; Martí-Fàbregas, J; Jiménez-Xarrié, E; Mimbrera, AD; Masjuan, J; García-Madrona, S; Domínguez-Mayoral, A; Villalonga, JM; Menéndez-Valladares, P; Solomonson, M

NATURE 621 ( 7977 ) E7 - + 2023年9月（ ISSN:0028-0836 eISSN:1476-4687 ）

　詳細を見る

出版者・発行元：Nature

DOI： 10.1038/s41586-023-06355-3

Web of Science

Scopus

PubMed
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Edahiro, R; Shirai, Y; Takeshima, Y; Sakakibara, S; Yamaguchi, Y; Murakami, T; Morita, T; Kato, Y; Liu, YC; Motooka, D; Naito, Y; Takuwa, A; Sugihara, F; Tanaka, K; Wing, JB; Sonehara, K; Tomofuji, Y; Namkoong, H; Tanaka, H; Lee, H; Fukunaga, K; Hirata, H; Takeda, Y; Okuzaki, D; Kumanogoh, A; Okada, Y; Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Tanaka, H; Lee, H; Saiki, R; Hyugaji, T; Shimizu, E; Katayama, K; Kanai, M; Naito, T; Sasa, N; Yamamoto, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Ichikawa, M; Nakamura, A; Harada, S; Sandhu, Y; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Shiroyama, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Tomono, K; Kato, K; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, STS; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Koji, S; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, HRYS; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Takano, T; Katayama, K; Ai, MSM; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K

NATURE GENETICS 55 ( 5 ) 753 - + 2023年5月（ ISSN:1061-4036 eISSN:1546-1718 ）

　詳細を見る

出版者・発行元：Nature Genetics

Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 healthy controls of Japanese ancestry with host genetic data. COVID-19 patients showed a low fraction of nonclassical monocytes (ncMono). We report downregulated cell transitions from classical monocytes to ncMono in COVID-19 with reduced CXCL10 expression in ncMono in severe disease. Cell–cell communication analysis inferred decreased cellular interactions involving ncMono in severe COVID-19. Clonal expansions of BCR were evident in the plasmablasts of patients. Putative disease genes identified by COVID-19 genome-wide association study showed cell type-specific expressions in monocytes and dendritic cells. A COVID-19-associated risk variant at the IFNAR2 locus (rs13050728) had context-specific and monocyte-specific expression quantitative trait loci effects. Our study highlights biological and host genetic involvement of innate immune cells in COVID-19 severity.

DOI： 10.1038/s41588-023-01375-1

Web of Science

Scopus

PubMed
Platypnea-Orthodeoxia Syndrome in Coronavirus Disease 2019 Pneumonia: A Case Report and Literature Review 査読

Tanimoto, T; Eriguchi, Y; Sato, T; Yonekawa, A; Miyake, N; Akashi, K; Shimono, N

INTERNATIONAL MEDICAL CASE REPORTS JOURNAL 16 201 - 207 2023年3月（ ISSN:1179-142X ）

　詳細を見る

記述言語：その他掲載種別：研究論文（学術雑誌）出版者・発行元：International Medical Case Reports Journal

Platypnea-orthodeoxia syndrome (POS) is a rare disorder associated with coronavirus disease 2019 (COVID-19) pneu-monia. However, POS may be underdiagnosed. We report the case of a 59-year-old female patient with POS complicated by pulmonary embolism in COVID-19. Imaging revealed ground-glass opacities predominantly in the lower lobes and a pulmonary embolus in the right upper lobe. She was diagnosed with POS due to marked postural discrepancies between supine and upright oxygen saturations and blood oxygenation. Intracardiac shunt, one of the etiologies of POS, was not detected by bubble contrast echocardiography, and postural de-saturation gradually improved with methylprednisolone and edoxaban administration. In our literature review, only 3 of the 16 patients with POS associated with COVID-19 had cardiac shunting, suggesting that moderate to severe COVID-19 causes POS without cardiac shunts. COVID-19-associated vasculopathy and lower lung lesion predominance in COVID-19 pneumonia may cause ventilation-perfusion mismatch due to gravitational shunting of blood into the poorly ventilated lower lungs in the upright position, which may ultimately cause POS. Hypoxemia impedes rehabilitation, whereas early initiation of supine positioning in bed, with knowledge of the pathophysiology of POS, may have a positive effect.

DOI： 10.2147/IMCRJ.S402537

Web of Science

Scopus

PubMed

researchmap
DOCK2 is involved in the host genetics and biology of severe COVID-19 査読

Namkoong, H; Edahiro, R; Takano, T; Nishihara, H; Shirai, Y; Sonehara, K; Tanaka, H; Azekawa, S; Mikami, Y; Lee, H; Hasegawa, T; Okudela, K; Okuzaki, D; Motooka, D; Kanai, M; Naito, T; Yamamoto, K; Wang, QBS; Saiki, R; Ishihara, R; Matsubara, Y; Hamamoto, J; Hayashi, H; Yoshimura, Y; Tachikawa, N; Yanagita, E; Hyugaji, T; Shimizu, E; Katayama, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Aoki, R; Nakamura, A; Harada, S; Sasano, H; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Suzuki, K; Naito, Y; Liu, YC; Takuwa, A; Sugihara, F; Wing, JB; Sakakibara, S; Hizawa, N; Shiroyama, T; Miyawaki, S; Kawamura, Y; Nakayama, A; Matsuo, H; Maeda, Y; Nii, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Kishikawa, T; Yamada, S; Kawabata, S; Kijima, N; Takagaki, M; Sasa, N; Ueno, Y; Suzuki, M; Takemoto, N; Eguchi, H; Fukusumi, T; Imai, T; Fukushima, M; Kishima, H; Inohara, H; Tomono, K; Kato, K; Takahashi, M; Matsuda, F; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, S; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Sakamoto, K; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, H; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Katayama, K; Ai, M; Fukui, Y; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K; Okada, Y

NATURE 609 ( 7928 ) 754 - + 2022年9月（ ISSN:0028-0836 eISSN:1476-4687 ）

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature

Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1–5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.

DOI： 10.1038/s41586-022-05163-5

Web of Science

Scopus

PubMed

researchmap
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force 査読

Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Tanaka, H; Lee, H; Saiki, R; Hyugaji, T; Shimizu, E; Katayama, K; Kanai, M; Naito, T; Sasa, N; Yamamoto, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Ichikawa, M; Nakamura, A; Harada, S; Sandhu, Y; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Shiroyama, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Tomono, K; Kato, K; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, S; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Koji, S; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, H; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Takano, T; Katayama, K; Ai, M; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K; Okada, Y

NATURE COMMUNICATIONS 13 ( 1 ) 4830 2022年8月（ ISSN:2041-1723 eISSN:2041-1723 ）

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Communications

Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.

DOI： 10.1038/s41467-022-32276-2

Web of Science

Scopus

PubMed

researchmap
A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections. 国際誌

Justin B Schaal, Yoshihiro Eriguchi, Dat Q Tran, Patti A Tran, Chase Hawes, Anthony E Cabebe, Kaitlyn Pike, Katie Trinh, André J Ouellette, Michael E Selsted

Scientific reports 11 ( 1 ) 23447 - 23447 2021年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

The emergence of infections by carbapenem resistant Enterobacteriaceae (CRE) pathogens has created an urgent public health threat, as carbapenems are among the drugs of last resort for infections caused by a growing fraction of multi-drug resistant (MDR) bacteria. There is global consensus that new preventive and therapeutic strategies are urgently needed to combat the growing problem of MDR bacterial infections. Here, we report on the efficacy of a novel macrocyclic peptide, minimized theta-defensin (MTD)-12813 in CRE sepsis. MTD12813 is a theta-defensin inspired cyclic peptide that is highly effective against CRE pathogens K. pneumoniae and E. coli in vivo. In mouse septicemia models, single dose administration of MTD12813 significantly enhanced survival by promoting rapid host-mediated bacterial clearance and by modulating pathologic cytokine responses, restoring immune homeostasis, and preventing lethal septic shock. The peptide lacks direct antibacterial activity in the presence of mouse serum or in peritoneal fluid, further evidence for its indirect antibacterial mode of action. MTD12813 is highly stable in biological matrices, resistant to bacterial proteases, and nontoxic to mice at dose levels 100 times the therapeutic dose level, properties which support further development of the peptide as a first in class anti-infective therapeutic.

DOI： 10.1038/s41598-021-02619-y
Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19. 国際誌

Hiromu Tanaka, Ho Lee, Atsuho Morita, Ho Namkoong, Shotaro Chubachi, Hiroki Kabata, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 113 74 - 81 2021年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND AND DESIGN: The coronavirus disease (COVID-19) pandemic is having a devastating effect worldwide. Host genome differences between populations may influence the severity of COVID-19. The Japan COVID-19 Task Force is conducting host genome analysis of hospitalized patients with COVID-19 from more than 70 institutions nationwide in Japan. This report describes the clinical characteristics of patients enrolled to date. RESULTS: The median (interquartile range) age of the 1674 patients included in the analysis was 59 (45-71) years, and more than half of the patients (66.2%) were male. Less than half of the patients (41.2%) had severe disease. The case fatality rate was 3.2%. CONCLUSIONS: Since this is a hospital-based study, the number of severe cases was relatively high, but the case fatality rate was relatively low, when compared to that of other countries. In the future, we will continue to enroll patients and conduct genome analyses of patients with COVID-19.

DOI： 10.1016/j.ijid.2021.09.070
p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. 国際誌

Keane K Y Lai, Xiaohui Hu, Keisuke Chosa, Cu Nguyen, David P Lin, Keith K Lai, Nobuo Kato, Yusuke Higuchi, Sarah K Highlander, Elizabeth Melendez, Yoshihiro Eriguchi, Patrick T Fueger, Andre J Ouellette, Nyam-Osor Chimge, Masaya Ono, Michael Kahn

Cancers 13 ( 6 ) 2021年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Differential usage of Kat3 coactivators, CBP and p300, by β-catenin is a fundamental regulatory mechanism in stem cell maintenance and initiation of differentiation and repair. Based upon our earlier pharmacologic studies, p300 serine 89 (S89) is critical for controlling differential coactivator usage by β-catenin via post-translational phosphorylation in stem/progenitor populations, and appears to be a target for a number of kinase cascades. To further investigate mechanisms of signal integration effected by this domain, we generated p300 S89A knock-in mice. We show that S89A mice are extremely sensitive to intestinal insult resulting in colitis, which is known to significantly increase the risk of developing colorectal cancer. We demonstrate cell intrinsic differences, and microbiome compositional differences and differential immune responses, in intestine of S89A versus wild type mice. Genomic and proteomic analyses reveal pathway differences, including lipid metabolism, oxidative stress response, mitochondrial function and oxidative phosphorylation. The diverse effects on fundamental processes including epithelial differentiation, metabolism, immune response and microbiome colonization, all brought about by a single amino acid modification S89A, highlights the critical role of this region in p300 as a signaling nexus and the rationale for conservation of this residue and surrounding region for hundreds of million years of vertebrate evolution.

DOI： 10.3390/cancers13061288
Inhibition of Stearoyl-CoA Desaturase Induces the Unfolded Protein Response in Pancreatic Tumors and Suppresses Their Growth. 国際誌

Kaitlin Skrypek, Steven Balog, Yoshihiro Eriguchi, Kinji Asahina

Pancreas 50 ( 2 ) 219 - 226 2021年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Pancreatic ductal adenocarcinoma is the fourth-leading cause of cancer death in the United States, and there is an urgent need for effective therapies. Stearoyl-CoA desaturase (SCD) is an enzyme localized in the endoplasmic reticulum and generates monounsaturated fatty acid from saturated fatty acid. In this study, we examined the role of SCD in pancreatic cancer. METHODS: We isolated epithelial cell adhesion molecule-positive pancreatic tumors from the Pdx1Cre;LSL-KrasG12D mouse and formed organoids in Matrigel. Using a SCD inhibitor, A939572, we tested its effects on growth and cell death in tumor organoids, tumors developed in the Pdx1Cre;LSL-KrasG12D mouse, and a human pancreatic ductal adenocarcinoma cell line, PANC-1. RESULTS: A939572 treatment rapidly induced degeneration of mouse tumor organoids and activated the unfolded protein response (UPR). Cotreatment of oleic acid, but not stearic acid, reduced the UPR in the organoids and rescued the inhibitory effect of the SCD inhibitor on their growth. Administration of A939572 to Pdx1Cre;LSL-KrasG12D mice caused cell death in early pancreatic tumors, but not in acini or islets. The SCD inhibitor induced the UPR in PANC-1 and suppressed their growth but did not induce cell death. CONCLUSIONS: The inhibition of the SCD enzyme causes an UPR and cell death in early pancreatic tumors.

DOI： 10.1097/MPA.0000000000001737
Clinical significance of SARS-CoV-2-specific IgG detection with a rapid antibody kit for COVID-19 patients. 国際誌

Yong Chong, Hideyuki Ikematsu, Naoki Tani, Yoko Arimizu, Haruka Watanabe, Yukako Fukamachi, Akiko Yonekawa, Sho Iwasaka, Ruriko Nishida, Yoshihiro Eriguchi, Noriko Miyake, Shinji Shimoda, Yoji Nagasaki, Nobuyuki Shimono, Koichi Akashi

Influenza and other respiratory viruses 15 ( 1 ) 13 - 18 2021年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The longitudinal observation of the detection of antibody responses to SARS-CoV-2 using antibody kits during the clinical course of COVID-19 is not yet fully investigated. OBJECTIVES: To understand the significance of the detection of anti-SARS-CoV-2 antibodies, particularly IgG, using a rapid antibody kit, during the clinical course of COVID-19 patients with different severities. METHODS: Sixty-three serum samples from 18 patients (5 asymptomatic and 13 symptomatic patients) were retrospectively examined using a commercial SARS-CoV-2 IgM/IgG antibody kit. PCR positivity of patient samples was also examined as a marker of current SARS-CoV-2 infection. RESULTS: IgG antibodies were detected in all cases in this study. The IgG detection rates reached 100.0% in samples collected on day 13 or later. IgG seropositivity after an initial negative status was observed in 13 patients (3/5 asymptomatic and 10/13 symptomatic cases). Interestingly, the persistence of both PCR and IgG positivity was detected in seven cases, of which three were asymptomatic. The longest overlap duration of the PCR and IgG positivity was 17 days in asymptomatic status. CONCLUSIONS: SARS-CoV-2-specific IgG production can be detected in all infected individuals, using a rapid antibody kit, irrespective of clinical status. However, these findings suggest that, in some infected individuals, particularly those with asymptomatic status, the presence of virus-specific IgG antibodies does not imply prompt viral clearance.

DOI： 10.1111/irv.12802
Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms 査読

Virginia Basso, Dat Q. Tran, Justin B. Schaal, Patti Tran, Yoshihiro Eriguchi, Diana Ngole, Anthony E. Cabebe, A. young Park, Paul M. Beringer, André J. Ouellette, Michael E. Selsted

Scientific reports 9 ( 1 ) 2019年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Invasive candidiasis is an increasingly frequent cause of serious and often fatal infections in hospitalized and immunosuppressed patients. Mortality rates associated with these infections have risen sharply due to the emergence of multidrug resistant (MDR) strains of C. albicans and other Candida spp., highlighting the urgent need of new antifungal therapies. Rhesus theta (θ) defensin-1 (RTD-1), a natural macrocyclic antimicrobial peptide, was recently shown to be rapidly fungicidal against clinical isolates of MDR C. albicans in vitro. Here we found that RTD-1 was rapidly fungicidal against blastospores of fluconazole/caspofungin resistant C. albicans strains, and was active against established C. albicans biofilms in vitro. In vivo, systemic administration of RTD-1, initiated at the time of infection or 24 h post-infection, promoted long term survival in candidemic mice whether infected with drug-sensitive or MDR strains of C. albicans. RTD-1 induced an early (4 h post treatment) increase in neutrophils in naive and infected mice. In vivo efficacy was associated with fungal clearance, restoration of dysregulated inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-10, and IL-17, and homeostatic reduction in numbers of circulating neutrophils and monocytes. Because these effects occurred using peptide doses that produced maximal plasma concentrations (Cmax) of less than 1% of RTD-1 levels required for in vitro antifungal activity in 50% mouse serum, while inducing a transient neutrophilia, we suggest that RTD-1 mediates its antifungal effects in vivo by host directed mechanisms rather than direct fungicidal activity. Results of this study suggest that θ-defensins represent a new class of host-directed compounds for treatment of disseminated candidiasis.

DOI： 10.1038/s41598-019-53402-z
Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency 査読

Eduardo R. Cobo, Ravi Holani, France Moreau, Kiminori Nakamura, Tokiyoshi Ayabe, Jennifer R. Mastroianni, Yoshihiro Eriguchi, Andre Ouellette, Kris Chadee

Infection and Immunity 86 ( 7 ) 2018年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Enteric α-defensins, termed cryptdins (Crps) in mice, and lysozymes secreted by Paneth cells contribute to innate host defense in the ileum. Antimicrobial factors, including lysozymes and β-defensins, are often embedded in luminal glycosylated colonic Muc2 mucin secreted by goblet cells that form the protective mucus layer critical for gut homeostasis and pathogen invasion. In this study, we investigated ileal innate immunity against Entamoeba histolytica, the causative agent of intestinal amebiasis, by inoculating parasites in closed ileal loops in Muc2+/+ and Muc2−/− littermates and quantifying Paneth cell localization (lysozyme expression) and function (Crp secretion). Relative to Muc2+/+ littermates, Muc2−/− littermates showed a disorganized mislocalization of Paneth cells that was diffusely distributed, with elevated lysozyme secretion in the crypts and on villi in response to E. histolytica. Inhibition of E. histolytica Gal/GalNAc lectin (Gal-lectin) binding with exogenous galactose and Entamoeba histolytica cysteine proteinase 5 (EhCP5)-negative E. histolytica had no effect on parasite-induced erratic Paneth cell lysozyme synthesis. Although the basal ileal expression of Crp genes was unaffected in Muc2−/− mice in response to E. histolytica, there was a robust release of proinflammatory cytokines and Crp peptide secretions in luminal exudates that was also present in the colon. Interestingly, E. histolytica-secreted cysteine proteinases cleaved the proregion of Crp4 but not the active form. These findings define Muc2 mucin as an essential component of ileal barrier function that regulates the localization and function of Paneth cells critical for host defense against microbes.

DOI： 10.1128/IAI.00208-18
Decreased secretion of Paneth cell α-defensins in graft-versus-host disease 査読

Y. Eriguchi, K. Nakamura, D. Hashimoto, S. Shimoda, N. Shimono, K. Akashi, T. Ayabe, T. Teshima

Transplant Infectious Disease 17 ( 5 ) 702 - 706 2015年10月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Intestinal microbial ecology is actively regulated by Paneth cell-derived antimicrobial peptides, α-defensins. Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (SCT). We previously demonstrated that Paneth cells are targeted by GVHD, and their expression of antimicrobial peptide α-defensins is impaired, leading to a loss of physiological diversity among the microflora and development of bloodstream infection. Herein, we evaluated whether fecal levels of α-defensins could be surrogate marker of intestinal dysbiosis. Methods: We directly measured α-defensin cryptdin-1 (Crp1) in fecal pellets of mice with GVHD by using a novel enzyme-linked immunosorbent assay. Results: Fecal levels of Crp1 were significantly decreased in mice with GVHD but unchanged in mice without GVHD after SCT. These were correlated with intestinal flora diversity. Conclusion: We demonstrate a link between reduced secretion of Paneth cell α-defensins and dysbiosis of intestinal flora in GVHD. Fecal levels of α-defensins could be surrogate markers for intestinal microbial homeostasis.

DOI： 10.1111/tid.12423
Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease 査読

Yoshihiro Eriguchi, Hidetaka Uryu, Kiminori Nakamura, Sonoko Shimoji, Shuichiro Takashima, Hiromi Iwasaki, Toshihiro Miyamoto, Nobuyuki Shimono, Daigo Hashimoto, Koichi Akashi, Tokiyoshi Ayabe, Takanori Teshima

Biology of Blood and Marrow Transplantation 19 ( 10 ) 1525 - 1529 2013年10月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

We recently demonstrated that expression of α-defensins, the major antimicrobial peptides produced by Paneth cells, was severely suppressed in mice with graft-versus-host disease (GVHD). In this study, we found that antibacterial lectin, regenerating islet-derived IIIγ (RegIIIγ) was upregulated in villous enterocytes, thus demonstrating the reciprocal control of enteric antimicrobial proteins in GVHD. Upregulation of RegIIIγ was mediated by a mechanism independent upon radiation-induced intestinal tract damage. MyD88-mediated signaling in intestinal epithelium was required for RegIIIγ upregulation in GVHD and antibiotic therapy downregulated RegIIIγ expression. These results suggest that MyD88-mediated sensing of the intestinal microbes disregulated in GVHD induces RegIIIγ upregulation in GVHD and argue a role for RegIIIγ in the pathogenesis of GVHD.

DOI： 10.1016/j.bbmt.2013.07.027
Evaluating the association between histological manifestations of cord colitis syndrome with GVHD 査読

S. Shimoji, K. Kato, Y. Eriguchi, K. Takenaka, H. Iwasaki, T. Miyamoto, Y. Oda, K. Akashi, T. Teshima

Bone Marrow Transplantation 48 ( 9 ) 1249 - 1252 2013年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Cord colitis syndrome (CCS) is a recently proposed clinical entity characterized by a persistent diarrheal illness after cord blood transplantation (CBT), which is not caused by GVHD or CMV colitis. CCS is histologically characterized by chronic active colitis with granulomatous inflammation and Paneth cell metaplasia suggesting chronicity. However, the specificity of these pathological features to CCS remains to be validated. We conducted a retrospective study of 49 patients who had diarrhea and underwent diagnostic colonoscopy with biopsy following allogeneic hematopoietic SCT. None of the patients met the clinical criteria for CCS. Chronic active colitis with granulomatous inflammation and Paneth cell metaplasia was present in 12/33 (36%) patients with biopsy-proven GVHD, 4/6 (67%) patients with CMV colitis and 2/15 (13%) patients with nonspecific colitis. In patients with GVHD and/or CMV colitis, these pathological features were present in 4/8 (50%) patients after CBT and in 11/26 (42%) patients undergoing BMT or PBSCT. These results demonstrate that chronic active colitis with granuloma and Paneth cell metaplasia is not only a specific feature of CCS but also is present in GVHD and CMV colitis, irrespective of stem cell source.

DOI： 10.1038/bmt.2013.44
Influence of inoculum size on MICs for methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus on in vitro 査読

Noriko Miyake, Masako Kadowaki, Yoriko Sato, Yoshihiro Eriguchi, Yoji Nagasaki, Yukiko Harada, Yujiro Uchida, Nobuyuki Shimono

Japanese Journal of Antibiotics 64 ( 4 ) 231 - 237 2011年8月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Using 49 clinical methicillin-susceptible Staphylococcus aureus isolates (MSSA) and 54 clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, we examined the change of MIC using five different inocula (2.5-4×10 ²cfu/spot - 2.5-4×10 ⁶cfu/spot). We found the big change of the MIC with the increase of the inoculum size in ampicillin against MSSA, and the change was small in cefazolin, meropenem, ciprofloxacin. For anti-MRSA antibiotics, we found the small change with the increase of the inoculums size in vancomycin and arbekacin, and the middle change in teicoplanin and linezolid against MSSA and MRSA. The data from this study suggest that in serious and high inocula infections caused by S. aureus, the presence of an inoculum effect should be considered in curing.
Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors 査読

Yujiro Uchida, Tomomi Mochimaru, Yuiko Morokuma, Makiko Kiyosuke, Masako Fujise, Fujiko Eto, Yoshihiro Eriguchi, Yoji Nagasaki, Nobuyuki Shimono, Dongchon Kang

International Journal of Antimicrobial Agents 35 ( 5 ) 444 - 450 2010年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

A significant problem in the field of infectious diseases is the increase in fluoroquinolone (FQ)-resistant Escherichia coli. Although mutation of strains and clonal dissemination are supposed to be the cause of this increase, little is known about the prevalence of this organism. We investigated 219 FQ-resistant E. coli strains in Japan and nine Asian countries by serotyping and genotyping. Seventy-one strains (32.4%) were serogroup O25, which was prevalent in South Korea, China and Japan, especially in the southwest part of Japan. Aerobactin, a virulence factor in uropathogenic and avian pathogenic E. coli, was associated with the presence of FQ-resistant O25 strains of E. coli. Seven of the seventy-one FQ-resistant E. coli O25 had extended-spectrum β-lactamase genes (six CTX-M-14 and one SHV-12), however, we were unable to find any E. coli O25-ST131 clone that produced CTX-M-15, which was previously reported to have emerged across continents. These data demonstrate that a clonal group of FQ-resistant and virulent E. coli recently became prevalent at least in East Asia and suggest that this might become a public health problem because the strains may acquire resistance to other antimicrobial agents.

DOI： 10.1016/j.ijantimicag.2009.12.012
Hematological unit invasive aspergillosis epidemiology 査読

Yoriko Maehara, Yoji Nagasaki, Masako Kadowaki, Yoshihiro Eriguchi, Noriko Miyake, Yujiro Uchida, Koji Nagafuji, Nobuyuki Shimono

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases 84 ( 2 ) 176 - 181 2010年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Invasive aspergillosis (IA) is a major cause of morbidity and mortality among the immunocompromised, especially those undergoing hematopoietic stem cell transplantation. With spore inhalation the usual infection route, such subjects must be protected from environmental spore contamination, necessitating measures such as high-efficiency particulate air (HEPA) filtration. In April 2006, we implemented a new transplantation unit with HEPA filtration. We retrospectively evaluated its efficacy for hospitalized transplantation unit subjects whose sera were tested for aspergillus galactomannan antigen between April 2004 and March 2007. Subjects numbered 265 (973 samples) categorized as definite, probable, or possible. The earliest IA onset date was when symptoms, positive radiological findings, or positive galactomannan antigen tests occurred, based on revised European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) definitions. We classified cases when IA occurred over 10 days after admission as hospital-acquired. No such cases were detected after November 2005 and IA incidence decreased significantly after the new unit began being used. Results suggest that the new unit and HEPA filtration helped eliminate nosocomial IA.

DOI： 10.11150/kansenshogakuzasshi.84.176
Combination therapy with micafungin and amphotericin B for invasive pulmonary aspergillosis in an immunocompromised mouse model 査読

Yoji Nagasaki, Yoshihiro Eriguchi, Yujiro Uchida, Noriko Miyake, Yoriko Maehara, Masako Kadowaki, Mine Harada, Koichi Akashi, Nobuyuki Shimono

Journal of Antimicrobial Chemotherapy 64 ( 2 ) 379 - 382 2009年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Objectives: Antifungal monotherapy with polyenes, azoles or echinocandins is not always effective for invasive pulmonary aspergillosis (IPA). The main purpose of this study was to evaluate the efficacy of a combination of micafungin and amphotericin B for the primary treatment of IPA in an immunocompromised mouse model. Methods: Female ICR mice were used in all experiments. An immunosuppressive state was induced in mice by an intraperitoneal injection of cyclophosphamide. Mice were intratracheally inoculated with Aspergillus fumigatus conidia, treated with micafungin, amphotericin B or both for 7 days, and were tested for their survival 20 days after the Aspergillus inoculation. Fungal burden in lungs, serum galactomannan index (GMI) and histopathology of lungs, spleen and kidneys were also evaluated. Results: Combination therapy with micafungin and amphotericin B gave excellent survival of infected mice compared with monotherapy with micafungin or amphotericin B alone. Combined therapy reduced the fungal burden in the lungs and the serum GM levels compared with monotherapy or untreated controls, resulting in a significant histological improvement with disappearance of fungi in the lungs. Conclusions: These findings suggest that combination therapy with micafungin and amphotericin B is more effective compared with monotherapy with either of them alone for IPA treatment.

DOI： 10.1093/jac/dkp175
Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus 査読

Noriko Tsuchimochi, Yujiro Uchida, Yoji Nagasaki, Yoshihiro Eriguchi, Yoriko Maehara, Masako Kadowaki, Nobuyuki Shimono

Japanese Journal of Chemotherapy 55 ( 5 ) 363 - 367 2007年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7%) and 159 strains (76.8%). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6%) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.
Rabeprazole-based eradication therapy for Helicobacter pylori A large-scale study in Japan 査読

H. Kuwayama, K. Asaka, T. Sugiyama, Y. Fukuda, N. Aoyama, Y. Hirai, T. Fujioka, Gakuyo Karasawa, Ryo Uyama, Mototsugu Kato, Yuichi Shimizu, Souichi Nakagawa, Ken Nishi, Shigeru Ozasa, Mineo Kudo, Takahiro Kamata, Masao Saito, Naoyuki Kawamura, Masako Tsuyuguchi, Hiroko Ooizumi, Takeaki Kobayashi, Asako Iijima, Tsuyoshi Yabana, Kazuyoshi Yamashita, Youji Harada, Teitetsu Niido, Yuri Yasuda, Yoko Iga, Hajime Kuwayama, Morio Takahashi, Hironobu Takada, Hiroshi Takada, Shigeki Oka, Hiroki Ichimura, Eiko Makino, Kazumasa Miki, Jun Miwa, Yasuo Matsubara, Takashige Tomita, Shigeru Koyama, Nobuhiro Sakaki, Masahiko Takahashi, Haruko Yokoyama, Yuji Koike, Tuyo To, Yoshiharu Satake, Makiyo Machida, Takashi Kawai, Satoru Taira, Kenji Nukaga, Naomi Uemura, Jyunichi Akiyama, Yuko Hiraga, Hitohiko Koizuka, Shigeaki Yasaka, Ryosuke Tajiri, Masao Kobayakawa, Akitaka Takahara, Mika Shimamoto, Hiroshi Murata, Toshihide Okada, Yoshihide Fujiyama, Shigeki Koyama, Masaya Sasaki, Tomoyuki Tsujikawa, Izumi Ishizuka, Kiyoshi Ashida, Hajime Takahashi, Takumi Fukuchi, Naomi Kiyota, Hiroshi Yamashita, Reiko Tsukamoto, Hiroshi Ito, Tomohiro Nishide, Haruki Kato, Takashi Ando, Koichi Terao, Nobuo Aoyama, Daisuke Shirasaka, Takao Tamura, Shunichi Yoshida, Seiichi Hirano, Yoshihiro Fukuda, Kazutoshi Hori, Toshihiko Tomita, Tahashi Sakagami, Kazuhiko Inoue, Mutsumi Hananoki, Norio Miyashima, Hirotsugu Okuda, Kazuhiro Harada, Toshihiro Honda, Masaharu Takeda, Ken Haruma, Toru Hidaka, Hiroaki Oogoshi, Shinji Nagata, Akira Tari, Hiroshi Tani, Hiroshi Mieno, Mitsuhiro Mihara, Yoshihiro Wada, Tomohiko Shimatani, Masaki Inoue, Takashi Kobayashi, Kazuhiko Yamauchi, Makoto Tsugita, Nobutoshi Kuniyoshi, Kazuma Fujimoto, Ryuichi Iwakiri, Hiroyuki Sakata, Seiji Tsunada, Akifumi Ootani, Atsushi Kikkawa, Yoshihiro Eriguchi, Koji Fukuyama, Masahiro Hattori, Tomofumi Tanaka, Kiwamu Hasuda, Hideyo Goto, Toshio Fujioka, Ryugo Sato, Kazunari Murakami, Masaaki Kodama, Tadayoshi Okimoto, Hajime Miyajima, Masami Ono, Tsuyoshi Arita, Syunzo Sato, Hisanori Abe

Alimentary Pharmacology and Therapeutics 25 ( 9 ) 1105 - 1113 2007年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Large-scale studies of rabeprazole-based Helicobacter pylori eradication therapy have not been reported in Japan. Aims: To evaluate H. pylori eradication by rabeprazole-based therapy with reference to antibiotic susceptibility, CYP2C19 genotype, and rabeprazole and clarithromycin dosages. Methods: From 35 centres 479 H. pylori-positive patients with gastric or duodenal ulcer were randomized to four treatment groups: Group 1 (10 mg rabeprazole + 750 mg amoxicillin + 200 mg clarithromycin twice daily for 7 days); Group 2 (10 mg, 750 mg, 400 mg); Group 3 (20 mg, 750 mg, 200 mg) and Group 4 (20 mg, 750 mg, 400 mg). Results: Eradication rates were 86% (102 of 119), 89% (97 of 109), 91% (106 of 116) and 90% (104 of 115) for Groups 1-4, respectively. The eradication rate was 95% (360 of 379) for clarithromycin- susceptible strains, and 50% (30 of 60) for clarithromycin-resistant strains. The eradication rates were 88% (332 of 379) and 96% (77 of 80) in extensive metabolizers and poor metabolizers, respectively. Conclusions: Rabeprazole-based therapies achieved 50% eradication of clarithromycin-resistant H. pylori, and even achieved good rates in extensive metabolizers. Accordingly, rabeprazole can be recommended as part of a first-line proton pump inhibitor-based triple therapy for H. pylori.

DOI： 10.1111/j.1365-2036.2007.03298.x
A case of relapsed ischemic colitis with colon cast-like stripped mucosa 査読

Yoshihiro Eriguchi, Seiji Tsunada, Sadahiro Amemori, Kenichiro Watanabe, Takehiro Fujise, Atsushi Kikkawa, Hibiki Ootani, Akifumi Ootani, Hiroyuki Sakata, Ryuichi Iwakiri, Masanobu Mizuguchi, Kazuma Fujimoto

Japanese Journal of Gastroenterology 103 ( 10 ) 1152 - 1156 2006年10月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

An 82-year-old woman who had 5 relapses of ischemic colitis was admitted with sudden lower abdominal pain. Colonoscopic examination performed on the 2nd day revealed colon cast-like stripped colonic mucosa in the lower portion of the descending colon. She was treaed conservatively. After 2 weeks, ischemic colitis healed, with slight residual stenosis. Most reports of colon cast indicated that colon cast was caused by abdominal aneurysm, operation, or external wound. The only predisposing conditions in this case were arteriosclerosis of abdominal aorta and chronic constipation. Arteriosclerosis and chronic constipation might be the important risk factors of ischemic colitis with colon cast and relapsing of ischemic colitis.

▼全件表示

書籍等出版物

腸管微小環境とGVHD

江里口芳裕（担当：単著）

科学評論社 2013年6月

　詳細を見る

担当ページ：月刊血液内科　66巻6号; p762-768 記述言語：日本語著書種別：学術書
移植片対宿主病はPaneth細胞の傷害を介して腸内環境を破綻させる

江里口芳裕（担当：単著）

メディカルレビュー社 2013年3月

　詳細を見る

担当ページ：Trends in Hematological Malignancies　Vol.5 No.1, p22-25 記述言語：日本語著書種別：一般書・啓蒙書
症例とエビデンスに学ぶ造血細胞移植と感染症

豊嶋崇徳、大島久美、神田善伸、角南一貴、日野雅之、澤正史、福原敬、竹中克斗、角川康夫、福田隆浩、櫻井政寿、岡本真一郎、名和由一郎、高橋義行、吉川哲史、緒方正男、星研一、植木俊光、小林光、石山謙、中尾眞二、和氣敦、石綿一哉、宮本敏弘、秋山秀樹、渡部昌実、柴崎康彦、古川達雄、長藤宏司、森尾友宏、井上雅美、加藤元博、花田良二、高見昭良、松本公一、加藤剛二、池亀和博、竹本雅子、川上学、中川雅史、衛藤徹也、荒岡秀樹、加古真一、加藤せい子、高橋聡、森慎一郎、吾郷浩厚、小林良二、亀井克彦、渡辺哲、森有紀、芦澤和人、金森平和、太田秀一、加藤光次（担当：共著）

医薬ジャーナル社 2011年8月

　詳細を見る

記述言語：日本語著書種別：一般書・啓蒙書

講演・口頭発表等

Interferon-γ Induces Paneth Cell Loss in Mouse Ileum Enteroid Cultures. 国際会議

Eriguchi Y, Nakamura K, Yokoi Y, Ayabe T, Selsted ME, and Ouellette AJ

Antimicrobial Peptides Gordon Research Conference 2017年2月

　詳細を見る

開催年月日： 2020年7月

記述言語：英語

開催地：Ventura, CA 国名：アメリカ合衆国
妊娠中期に激烈な経過をとったA群溶連菌(GAS)感染症の1剖検例

江里口芳裕、李守永、藤村直幸、杉森宏、橋爪誠、矢幡秀昭、和氣徳夫

第39回日本集中治療医学会 2012年2月

　詳細を見る

開催年月日： 2012年2月

会議種別：シンポジウム・ワークショップパネル（公募）

開催地：千葉　幕張メッセ国名：日本国

妊娠中の劇症型GAS感染症は、しばしば感染巣の同定が困難である。特に「劇症分娩型」は妊娠末期の分娩前後の進行が急激で、致命率が高い。我々は、妊娠18週に発症し、劇症分娩型に類似した病像を呈した例を経験したので報告する。症例：35歳女性、妊娠・分娩歴：G2P1 現病歴：5月上旬にGAS感染症と診断、CTRX3日間投与と3世代経口セフェム薬で改善。5月27日より咽頭痛、29日に39度の発熱と倦怠感が出現し、通院中の産婦人科に昼頃受診。軽度咽頭発赤と尿潜血を認め、CFPN-PI処方され帰宅。17時より下腹部痛増強し同医再診、19時FMOX投与後に胎児死亡となり、緊急搬送。20時30分の来院時より徐々に呼吸状態悪化、22時の胸部X線で肺胞出血が疑われ、またMOFと診断。23時10分ICU入室し、人工呼吸管理、ABPC+MEPM、Nad/Adr+DOB、rTM+AT- IIIの投与、CHDF/PMX、RCC/FFP/PC輸血、IVIG行うも翌6時44分死亡。血液培養よりGAS検出されたが、剖検上、原発巣同定は困難だった。
GVHDにおける腸内環境招待

江里口芳裕

第16回九州骨髄移植カンファレンス 2011年11月

　詳細を見る

開催年月日： 2011年11月

会議種別：口頭発表（一般）

開催地：福岡国名：日本国

1970年代の骨髄移植治療の黎明期にグラム陰性桿菌敗血症の発症が多いことが報告されており、現在では、予防内服が死亡率の改善を示したことから、骨髄移植に伴うグラム陰性桿菌敗血症のメカニズムは未解明のまま、抗菌薬の予防投与が一般的である。　我々はこの病態が、腸内細菌の腸管からのbacterial translocationによると考え、そのメカニズムを解明するために、骨髄移植によるGVHDモデルマウスを使用し検討した結果を報告する。
劇症型A群溶連菌感染症の1症例

江里口　芳裕、李　守永、藤村　直幸、大川　彦宏、矢幡　秀昭、橋爪　誠

感染症フォーラム2011 in 九州 2011年8月

　詳細を見る

開催年月日： 2011年8月

会議種別：口頭発表（一般）

開催地：福岡国名：日本国
造血幹細胞移植の新たな感染対策

江里口芳裕、前原依子、下野信行、宮本敏浩、赤司浩一、豊嶋崇徳

第44 回日本無菌生物ノートバイオロジー学会総会 2011年1月

　詳細を見る

開催年月日： 2011年1月

会議種別：シンポジウム・ワークショップパネル（公募）

開催地：札幌国名：日本国
Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting production of enteric defensins. 国際会議

Yoshihiro Eriguchi, Shuichiro Takashima, Noriko Miyake, Yoji Nagasaki, Nobuyuki Shimono, Koichi Akashi, and Takanori Teshima

52nd ASH Annual Meeting and Exposition 2010年12月

　詳細を見る

開催年月日： 2010年12月

会議種別：口頭発表（一般）

開催地：Orlando, FL, United States 国名：アメリカ合衆国

Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting production of enteric defensins.
内視鏡により止血しえた回盲部Dieulafoy潰瘍の2例

江里口芳裕　馬場英司　竹山泰守　矢野正浩

第87回日本消化器内視鏡学会九州支部例会 2009年6月

　詳細を見る

開催年月日： 2009年6月

会議種別：口頭発表（一般）

開催地：福岡国名：日本国
ヘルペス腸炎に偽膜性腸炎を併発した血管型ベーチェット病の1症例

江里口芳裕、隅田幸祐、長崎洋司、馬場英司、塚本浩、下野信行、赤司浩一、伏見文良、田宮貞史、小田義直

第87回日本消化器内視鏡学会九州支部例会 2009年6月

　詳細を見る

開催年月日： 2009年6月

会議種別：口頭発表（一般）

開催地：福岡国名：日本国
急性GVHDと腸内細菌叢バランスによる相互作用

江里口芳裕、高嶋秀一郎、門脇雅子、原田由紀子、長崎洋司、三宅典子、豊嶋崇徳、下野　信行、赤司浩一

第83回感染症学会総会 2009年5月

　詳細を見る

開催年月日： 2009年5月

会議種別：口頭発表（一般）

国名：日本国
Graft-Versus-Host Disease Targets Ovary and Causes Infertility After Allogeneic Hematopoietic Stem Cell Transplantation. 国際会議

Shimoji S, Kato K, Tsujigiwa H, Eriguchi Y, Lee L, Uryu H, Takashima S, Hashimoto D, Akashi K, and Teshima T

55th ASH Annual Meeting and Exposition 2013年12月

　詳細を見る

開催年月日： 2020年12月 - 2013年12月

記述言語：英語

開催地：New Orleans 国名：アメリカ合衆国
Listeria monocytogenesによる感染性心内膜炎の一例

岩坂翔，上原晶子，中嶋舞，門脇雅子，江里口芳裕，内田勇二郎，下野信行

第81回日本感染症学会西日本地方会学術集会 2011年10月

　詳細を見る

開催年月日： 2011年10月

会議種別：口頭発表（一般）

開催地：北九州国名：日本国
同種臍帯血移植まで行ったが救命できなかった慢性活動性EBウイルス感染症（CAEBV）の1例

斧沢京子，長崎洋司，岩崎教子，隅田幸祐，原田由紀子，門脇雅子，江里口芳裕，内田勇二郎，下野信行

第81回日本感染症学会西日本地方会学術集会 2011年10月

　詳細を見る

開催年月日： 2011年10月

会議種別：口頭発表（一般）

国名：日本国
当院でのカンジダ眼内炎についての考察

門脇雅子，長崎洋司，三宅典子，江里口芳裕，斧沢京子，岩崎教子，内田勇二郎，下野信行

第81回日本感染症学会西日本地方会学術集会 2011年10月

　詳細を見る

開催年月日： 2011年10月

会議種別：口頭発表（一般）

開催地：北九州国名：日本国
当院のCOVID-19に罹患した造血器悪性腫瘍患者におけるウイルス排出期間と臨床像に関する検討

米川晶子, 三宅典子, 江里口芳裕, 西田留梨子, 鄭湧, 下野信行

感染症学雑誌 2024年3月 (一社)日本感染症学会

　詳細を見る

記述言語：日本語

▼全件表示

所属学協会

日本環境感染学会
日本化学療法学会
日本救急医学会
日本感染症学会
日本消化器内視鏡学会
日本消化器病学会
日本内科学会
腸内細菌学会

　詳細を見る

researchmap
日本環境感染学会

　詳細を見る

researchmap
日本消化管学会

　詳細を見る

researchmap
日本消化器病学会

　詳細を見る

researchmap
日本消化器内視鏡学会

　詳細を見る

researchmap
日本救急医学会

　詳細を見る

researchmap
日本感染症学会

　詳細を見る

researchmap
日本化学療法学会

　詳細を見る

researchmap

▼全件表示

学術貢献活動

学術論文等の審査

役割：査読

2023年

　詳細を見る

種別：査読等

外国語雑誌　査読論文数：1

日本語雑誌　査読論文数：0

国際会議録　査読論文数：0

国内会議録　査読論文数：0
シンポジスト

第44回日本無菌生物ノートバイオロジー学会総会（札幌） 2011年1月

　詳細を見る

種別：大会・シンポジウム等

共同研究・競争的資金等の研究課題

自己免疫疾患における加齢性クローナル造血の関連についての検討

研究課題/領域番号：22K08565 2022年4月 - 2025年3月

科学研究費助成事業基盤研究(C)

小野伸之, 前田高宏, 江里口芳裕, 仙波雄一郎

　詳細を見る

資金種別：科研費

本研究では加齢性クローナル造血(clonal hematopoiesis: CH)と自己免疫疾患発症との関連を解明する。CHは加齢による体細胞変異を有しながら、悪性化していない造血細胞を指す。CHは血液腫瘍発症のリスクとなり重要であるが、近年 CH由来の細胞がinflammagingを誘導し、動脈硬化性疾患発症に関わっていることがわかった。我々はCHによるinflammagingが高齢発症自己免疫疾患の病態でも重要な役割を果たすと仮説し、本研究を立案した。CHが関わる自己免疫疾患を同定し、CHがどのような免疫異常を誘導し、発症に関わるかを解明する。

CiNii Research
腸管移植片対宿主病におけるバクテリアルトランスロケーションの病態解明

研究課題/領域番号：20K17465 2020年 - 2023年

日本学術振興会科学研究費助成事業若手研究

江里口芳裕

　詳細を見る

担当区分：研究代表者資金種別：科研費

造血幹細胞移植後の腸管からのバクテリアルトランスロケーションによる敗血症は、致死的な合併症であり、治療成績を大きく左右する。移植周術期の抗菌薬による腸管内殺菌等の試みにより治療成績は改善したが、長期の抗菌薬投与は耐性菌の定着を促し、治療に難渋する耐性菌感染症が問題となっている。今までは、無菌室や腸管内殺菌など、環境や病原体に関わる宿主外の因子に焦点が当てられてきたが、これでは多剤耐性菌の問題は解決できない。本研究では、従来研究されてきた病原体因子ではなく、宿主因子である病原体の侵入門戸に焦点を当て、新規治療法の開発を行う。

CiNii Research
Graft-Versus-Host-Diseaseにおける腸管組織の抗菌物質発現に関する疫学的調査

2011年5月 - 2016年3月

九州大学

　詳細を見る

担当区分：研究分担者

造血器悪性腫瘍に対する造血幹細胞移植後の腸管GVHDは重大な合併症であり、腸管上皮の障害により腸管の抗菌ペプチドの発現量に大きな変化が起こることが予想される。
我々は、GVHDマウスモデルにて、腸管GVHD発症により、腸管組織での抗菌ペプチドのmRNA発現量が変化し、それとともに、腸内細菌叢が大きく変化することを突き止めた。また、正常腸内細菌叢は偏性嫌気性菌である共生菌が主体であるが、腸管GVHD発症時は、病原性の高い大腸菌が最優勢菌となり、その大腸菌が腸管からtranslocationすることを明らかにした。
大腸菌のようなグラム陰性桿菌による感染症はGVHDを悪化させることが知られており、また、日常診療では、このようなグラム陰性桿菌感染症がGVHD発症後の致死的な合併症となるが、この実際の病態については知られていない。我々は、このような病態を解明すべく、病理組織診断時に採取された腸管組織における抗菌ペプチドの発現を評価し、関連する臨床項目についてカルテを調べ、後方視的に調査することを計画した。
造血器悪性腫瘍患者における腸内細菌叢に関する疫学的調査

2011年5月 - 2016年3月

九州大学病院

　詳細を見る

担当区分：研究分担者

造血器悪性腫瘍に対する放射線・化学療法や、造血幹細胞移植後の腸管移植片対宿主病は、腸管上皮を傷害し、腸管免疫の破たんから正常腸内細菌叢が大きく乱されることが予想される。
我々は、移植片対宿主病マウスモデルにて、腸管移植片対宿主病発症により、腸管組織での抗菌ペプチドのmRNA発現量の変化にともない腸内細菌叢が大きく変化することを突き止めた。また、正常腸内細菌叢は偏性嫌気性菌である共生菌が主体であるが、腸管移植片対宿主病発症時は、病原性の高い大腸菌が最優勢菌となり、その大腸菌が腸管からtranslocationすることを明らかにした。
大腸菌のようなグラム陰性桿菌による感染症は移植片対宿主病を悪化させることが知られており、また、日常診療では、このようなグラム陰性桿菌感染症が移植片対宿主病発症後の致死的な合併症となるが、この実際の病態については知られていない。我々は、このような病態を解明すべく、造血器悪性腫瘍で治療中に便培養で採取された便検体を用いて、腸内菌叢を評価し、関連する臨床項目についてカルテを調べ、調査することを計画した。
ＧＶＨＤモデルマウスの腸内フローラ変化のメカニズムとＧＶＨＤの病態へ及ぼす影響

2010年 - 2011年

財団法人ヤクルト・バイオサイエンス研究財団

　詳細を見る

担当区分：研究代表者資金種別：受託研究

教育活動概要

学生のベッドサイドでの教育、研修医・後期研修医への指導。
大学院生への研究指導を行っている。
また、他科へのコンサルテーション、インフェクションコントロールチームとしての教育ラウンドにより、感染症診療の教育活動を行っている。

社会貢献・国際連携活動概要

新型コロナウイルス感染症診療の拠点としての九州大学病院で、感染症専門医として診療に従事している。
外来及び入院診療にて、難渋する感染症の紹介を受けている。
海外の研究室との共同研究を継続している。

海外渡航歴

2013年4月 - 2019年8月

滞在国名1：アメリカ合衆国滞在機関名1：Keck School of Medicine of USC, Department of Pathology and Laboratory Medicine

学内運営に関わる各種委員・役職等

2023年4月 - 2024年3月部門外来医長

専門診療領域

生物系／医歯薬学／内科系臨床医学／消化器内科学
生物系／医歯薬学／内科系臨床医学／膠原病・アレルギー・感染症内科学
生物系／医歯薬学／外科系臨床医学／救急医学

臨床医資格

指導医

日本感染症学会
認定医

日本内科学会
専門医

日本消化器内視鏡学会
専門医

日本消化器病学会
専門医

日本救急医学会

医師免許取得年

2001年

特筆しておきたい臨床活動

院内・ICU内での感染管理