2024/10/29 更新

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写真a

エリグチ ヨシヒロ
江里口 芳裕
ERIGUCHI YOSHIHIRO
所属
九州大学病院 免疫・膠原病・感染症内科 助教
医学部 医学科(併任)
職名
助教
電話番号
0926425228
プロフィール
移植片対宿主病と感染免疫に関する研究 新型コロナウイルスの宿主免疫に関する研究 臨床医学実習のベッドサイド、クリニカルクラークシップでの学生指導 臨床実習前OSCE(実技試験)評価者 共用試験医学系臨床実習後OSCE(Post-cc OSCE)評価者

学位

  • 医学博士

経歴

  • 佐賀大学(消化器内科) Keck School of Medicine of USC, Department of Pathology and Laboratory Medicine (Postdoctoral Scholar-Research Associate)

研究テーマ・研究キーワード

  • 研究テーマ:腸管GVHDと腸内菌叢のクロストーク、腸管免疫

    研究キーワード:腸管GVHD、腸内菌叢、腸管免疫

    研究期間: 2006年4月 - 2012年12月

受賞

  • Best Research Paper Publication in the Postdoctoral Scholar Category at The 22nd Annual Pathology Conference, Keck School of Medicine of USC

    2019年2月   Essential role of interferon-gamma in T cell-associated intestinal inflammation

  • Best Poster Presentation Honorable Mention in the Postdoctoral Scholar Category at The 19th Annual Pathology Conference, Keck School of Medicine of USC

    2016年2月   Keck School of Medicine of USC  

  • 平成25年度 日本感染症学会 西日本地方会 感染症優秀論文賞(基礎的研究領域)

    2013年11月   日本感染症学会   Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. 江里口芳裕(Dept. Pathology & Lab Medicine, Keck School of Medicine of University of Southern California) Blood. 2012; 120: 223-231.

  • 52nd ASH Travel Award, 52nd American Society of Hematology Annual Meeting and Exposition

    2010年12月   American Society of Hematology  

論文

  • Breakthrough candidemia with hematological disease: Results from a single-center retrospective study in Japan, 2009–2020 査読

    Nishida, R; Eriguchi, Y; Miyake, N; Nagasaki, Y; Yonekawa, A; Mori, Y; Kato, K; Akashi, K; Shimono, N

    MEDICAL MYCOLOGY   61 ( 6 )   2023年6月   ISSN:1369-3786 eISSN:1460-2709

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Medical Mycology  

    Breakthrough candidemia (BrC) is a significant problem in immunocompromised patients, particularly those with hematological disorders. To assess the characteristics of BrC in patients with hematologic disease treated with novel antifungal agents, we collected clinical and microbiological information on said patients from 2009 to 2020 in our institution. Forty cases were identified, of which 29 (72.5%) received hematopoietic stem cell transplant (HSCT)-related therapy. At BrC onset, the most administered class of antifungal agents were echinocandins, administered to 70% of patients. Candida guilliermondii complex was the most frequently isolated species (32.5%), followed by C. parapsilosis (30%). These two isolates were echinocandin-susceptible in vitro but had naturally occurring FKS gene polymorphisms that reduced echinocandin susceptibility. Frequent isolation of these echinocandin-reduced-susceptible strains in BrC may be associated with the widespread use of echinocandins. In this study, the 30-day crude mortality rate in the group receiving HSCT-related therapy was significantly higher than in the group not receiving it (55.2% versus 18.2%, P =. 0297). Most patients affected by C. guilliermondii complex BrC (92.3%) received HSCT-related therapy and had a 30-day mortality rate of 53.8%; despite treatment administration, 3 of 13 patients had persistent candidemia. Based on our results, C. guilliermondii complex BrC is a potentially fatal condition in patients receiving HSCT-related therapy with echinocandin administration.

    DOI: 10.1093/mmy/myad056

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  • Essential role of IFN-γ in T cell-associated intestinal inflammation 査読

    Yoshihiro Eriguchi, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Shuichiro Takahashi, Daigo Hashimoto, Takanori Teshima, Tokiyoshi Ayabe, Michael E. Selsted, André J. Ouellette

    3 ( 18 )   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Paneth cells contribute to small intestinal homeostasis by secreting antimicrobial peptides and constituting the intestinal stem cell (ISC) niche. Certain T cell-mediated enteropathies are characterized by extensive Paneth cell depletion coincident with mucosal destruction and dysbiosis. In this study, mechanisms of intestinal crypt injury have been investigated by characterizing responses of mouse intestinal organoids (enteroids) in coculture with mouse T lymphocytes. Activated T cells induced enteroid damage, reduced Paneth cell and Lgr5+ ISC mRNA levels, and induced Paneth cell death through a caspase-3/7-dependent mechanism. IFN-γ mediated these effects, because IFN-γ receptor-null enteroids were unaffected by activated T cells. In mice, administration of IFN-γ induced enteropathy with crypt hyperplasia, villus shortening, Paneth cell depletion, and modified ISC marker expression. IFN-γ exacerbated radiation enteritis, which was ameliorated by treatment with a selective JAK1/2 inhibitor. Thus, IFN-γ induced Paneth cell death and impaired regeneration of small intestinal epithelium in vivo, suggesting that IFN-γ may be a useful target for treating defective mucosal regeneration in enteric inflammation.

    DOI: 10.1172/jci.insight.121886

  • Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins 査読 国際誌

    120 ( 1 )   2012年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    同種造血幹細胞移植は様々な血液疾患に対して根治的な治療方法である。移植片対宿主病(Graft-versus-host disease :GVHD)と感染症は、この造血幹細胞移植の厄介な合併症であり、GVHDと感染症は互いに影響を与えていると推測されている。本研究では、GVHDと感染症の相互関係をマウスモデルにより解析した。
     αディフェンシンは、病原菌に対し殺菌活性があり、共生菌に対しては活性を有さない選択的抗菌活性を持った抗菌ペプチドである。Paneth細胞は、このαディフェンシンを分泌することにより腸内細菌叢を制御している。我々は、Paneth細胞がGVHDの標的となり、腸管でのαディフェンシンの発現が減少することを発見した。
     腸内細菌叢の分子生物学的解析では、GVHD発症マウスで腸内細菌叢の多様性が減少する一方で、正常細菌叢では0.1%にも満たず、敗血症の病因となる大腸菌が異常増殖することを示した。この細菌叢の変化は、GVHD発症マウスにのみみられ、移植前処置である放射線照射による腸管障害とは無関係であり、菌叢の変化の度合いはGVHDの重症度と有意に相関した。また、大腸菌に抗菌活性のあるポリミキシンBの経口投与は、大腸菌の異常増殖を抑え、GVHDを軽減した。
     これらの結果は、GVHD発症により正常腸内細菌叢から、病原菌が爆発的に増加した異常細菌叢へと変移する新規のメカニズムと、今まで認識されていなかったGVHDと同種造血幹細胞移植後に発症する感染症との関連を明らかにした。

    DOI: doi:10.1182/blood-2011-12-401166

  • Clinical and virological features of SARS-CoV-2 Omicron variant-infected immunocompromised patients receiving immunosuppressive medications

    Nakamura, K; Goto, T; Shiraishi, K; Yonekawa, A; Eriguchi, Y; Akashi, K; Shimono, N; Chong, Y

    BMC INFECTIOUS DISEASES   24 ( 1 )   736   2024年7月   eISSN:1471-2334

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    記述言語:英語   出版者・発行元:BMC Infectious Diseases  

    Background: The prognosis of immunocompromised individuals with COVID-19 remains a significant concern. Information regarding the clinical and virological characteristics of immunocompromised patients infected with SARS-CoV-2 during the Omicron variant period is limited. Methods: Medical records of patients admitted to our hospital with COVID-19 during the Omicron (BA.1–5) epidemic were retrospectively reviewed. Clinical, virological (nasopharyngeal swabs and blood), and serological data were compared between immunocompromised patients receiving immunosuppressive medications (calcineurin inhibitors, mycophenolate mofetil, or steroids) and control patients not receiving immunosuppressive medications. Results: Twenty-eight immunocompromised patients (25 transplant recipients) and 26 control patients were included. Fourteen of the immunocompromised patients (50%) received monoclonal antibodies. The immunocompromised group included 15 mild/moderate (53.6%), 10 severe (35.7%), and three critical (10.7%) disease severities. The mortality rate due to COVID-19 during hospitalization was 3.6% (1/28) in the immunocompromised group, with no difference between the two groups. Three cases of re-exacerbation after discharge occurred in the immunocompromised group and none in the control group. Linear regression based on nasopharyngeal real-time-PCR cycle threshold (Ct) values according to the time since symptom onset showed markedly slower viral clearance in the immunocompromised group than in the control group (Pslope = 0.078). In the immunocompromised group, patients who received monoclonal antibodies showed faster viral clearance than those who did not receive monoclonal antibodies. The convalescent anti-spike IgG titers were comparable to those in the control group in patients who received monoclonal antibodies and significantly lower than those in the control patients in patients who did not receive monoclonal antibodies (P < 0.001). The prevalence of viremia at onset was significantly higher in the immunocompromised group than in the control group (35.7%, [10/28] vs. 11.5%, [3/26]; P = 0.003). All three patients with critical disease severity in the immunocompromised group exhibited viremia, one of whom died. All three patients with viremia in the control group were critical, of whom two died. Conclusions: Immunocompromised individuals receiving immunosuppressive medications are more likely to show delayed post-infection SARS-CoV-2 viral clearance and the development of viremia, potentially resulting in worsening severity and outcomes, especially in viremic patients, even during the Omicron epidemic.

    DOI: 10.1186/s12879-024-09633-1

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  • Streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis from retroperitoneal panniculitis during the treatment with anti-IL-6 receptor antibody: A case report(タイトル和訳中)

    Fujimoto Sho, Eriguchi Yoshihiro, Nakamura Rinto, Kamikawa Sota, Yonekawa Akiko, Miyake Noriko, Ono Nobuyuki, Niiro Hiroaki

    Modern Rheumatology Case Reports   8 ( 2 )   255 - 258   2024年7月

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    記述言語:英語   出版者・発行元:Oxford University Press  

  • Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study

    Matsubara Y., Kiyohara H., Mikami Y., Nanki K., Namkoong H., Chubachi S., Tanaka H., Azekawa S., Sugimoto S., Yoshimatsu Y., Sujino T., Takabayashi K., Hosoe N., Sato T., Ishii M., Hasegawa N., Okada Y., Koike R., Kitagawa Y., Kimura A., Imoto S., Miyano S., Ogawa S., Fukunaga K., Kanai T., Chubachi S., Namkoong H., Fukushima T., Tanaka H., Lee H., Otake S., Nakagawara K., Morita A., Watase M., Sakurai K., Ogawa T., Kusumoto T., Masaki K., Kabata H., Ikemura S., Okamori S., Terai H., Kamata H., Uchida S., Uno S., Hasegawa N., Takahashi K., Sasano H., Kitagawa Y., Harada N., Takagi H., Nakamura A., Naito T., Hiki M., Matsushita Y., Aoki R., Harada S., Sasaki J., Morisaki H., Uwamino Y., Mikami Y., Ishihara R., Matsubara Y., Kiyohara H., Sugimoto S., Yoshimatsu Y., Nishimura T., Sato T., Ueda T., Azuma M., Saito R., Sado T., Miyazaki Y., Sato R., Haruta Y., Nagasaki T., Hasegawa Y., Yasui Y., Ueda S., Tada A., Miyawaki M., Yamamoto M., Yoshida E., Hayashi R., Nagasaka T., Arai S., Kaneko Y., Sasaki K., Ishiguro T., Isono T., Shibata S., Matsui Y., Hosoda C., Takano K., Nishida T., Kobayashi Y., Takaku Y., Takayanagi N., Tagaya E.

    Journal of Gastroenterology   59 ( 3 )   195 - 208   2024年3月   ISSN:09441174

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    出版者・発行元:Journal of Gastroenterology  

    Background: Research on whether gastrointestinal symptoms correlate with the severity of Coronavirus Disease 2019 (COVID-19) has been inconclusive. This study aimed to clarify any associations between gastrointestinal symptoms and the prognosis of COVID-19. Methods: We collected data from the Japanese nationwide registry for COVID-19 to conduct a retrospective cohort study. Data from 3498 Japanese COVID-19 patients, diagnosed at 74 facilities between February 2020 and August 2022, were analyzed in this study. Hospitalized patients were followed up until discharge or transfer to another hospital. Outpatients were observed until the end of treatment. Associations between gastrointestinal symptoms and clinical outcomes were investigated using multivariable-adjusted logistic regression models. Results: The prevalence of diarrhea, nausea/vomiting, abdominal pain, and melena were 16.6% (581/3498), 8.9% (311/3498), 3.5% (121/3498), and 0.7% (23/3498), respectively. In the univariable analysis, admission to intensive care unit (ICU) and requirement for mechanical ventilation were less common in patients with diarrhea than those without (ICU, 15.7% vs. 20.6% (p = 0.006); mechanical ventilation, 7.9% vs. 11.4% (p = 0.013)). In the multivariable-adjusted analysis, diarrhea was associated with lower likelihood of ICU admission (adjusted odds ratio (aOR), 0.70; 95% confidence interval (CI), 0.53–0.92) and mechanical ventilation (aOR, 0.61; 95% CI, 0.42–0.89). Similar results were obtained in a sensitivity analysis with another logistic regression model that adjusted for 14 possible covariates with diarrhea (ICU; aOR, 0.70; 95% CI, 0.53–0.93; mechanical ventilation; aOR 0.62; 95% CI, 0.42–0.92). Conclusions: Diarrhea was associated with better clinical outcomes in COVID-19 patients.

    DOI: 10.1007/s00535-023-02071-x

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  • Streptococcal toxic shock syndrome due to <i>Streptococcus dysgalactiae</i> subsp.<i> equisimilis from </i>retroperitoneal panniculitis during the treatment with anti-IL-6 receptor antibody: A case report 査読

    Fujimoto, S; Eriguchi, Y; Nakamura, R; Kamikawa, S; Yonekawa, A; Miyake, N; Ono, N; Niiro, H

    MODERN RHEUMATOLOGY CASE REPORTS   8 ( 2 )   255 - 258   2024年1月   eISSN:2472-5625

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Modern Rheumatology Case Reports  

    A 53-year-old man with adult-onset Still’s disease developed severe streptococcal toxic shock syndrome (STSS) due to Streptococcus dysgalactiae subsp. equisimilis (SDSE), following retroperitoneal panniculitis. He was receiving tocilizumab (TCZ), an interleukin-6 receptor inhibitor. The modifying effect of TCZ on the immune response and the pathophysiology of SDSE infection may have led to retroperitoneal panniculitis and atypical STSS with delayed shock and flare of soft tissue inflammation.

    DOI: 10.1093/mrcr/rxae001

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  • A second update on mapping the human genetic architecture of COVID-19

    Kanai, M; Andrews, SJ; Cordioli, M; Stevens, C; Neale, BM; Daly, M; Ganna, A; Kanai, M; Andrews, SJ; Cordioli, M; Pathak, GA; Ganna, A; Iwasaki, A; Karjalainen, J; Mehtonen, J; Pathak, GA; Andrews, SJ; Kanai, M; Cordioli, M; Pirinen, M; Stevens, C; Chwialkowska, K; Trankiem, A; Balaconis, MK; Veerapen, K; Wolford, BN; Ahmad, HF; Andrews, S; Puoti, KAV; Boer, C; Boua, PR; Butler-Laporte, G; Cadilla, CL; Chwialkowska, K; Colombo, F; Douillard, V; Dueker, N; Dutta, AK; El-Sherbiny, YM; Eltoukhy, MM; Esmaeeli, S; Faucon, A; Fave, MJ; Cadenas, IF; Francescatto, M; Francioli, L; Franke, L; Fuentes, M; Durán, RG; Cabrero, DG; Harry, EN; Jansen, P; Szentpéteri, JL; Kaja, E; Kanai, M; Kirk, C; Kousathanas, A; Krieger, JE; Patel, SK; Lemaçon, A; Limou, S; Lió, P; Marouli, E; Marttila, MM; Medina-Gómez, C; Michaeli, Y; Migeotte, I; Mondal, S; Moreno-Estrada, A; Moya, L; Nakanishi, T; Nasir, J; Pasko, D; Pathak, GA; Pearson, NM; Pereira, AC; Priest, J; Prijatelj, V; Prokic, I; Teumer, A; Várnai, R; 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Diaz-Olavarrieta, C; Valdés, PA; Muñóz-Hernández, LL; Mehta, RP; Elías-López, D; Tusié-Luna, T; Pajukanta, P; Sukhatme, MG; Moreno-Macías, H; Huerta-Chagoya, A; Ruth, J; Ochoa-Guzmán, A; González-Behn-Eschenburg, S; García-Grimshaw, M; Guillen-Pineda, LE; Vargas-Martínez, MD; Rodríguez, M; Rodríguez-Guillén, R; Ordoñez, ML; Segura-Kato, Y; Rajme-López, S; González-Lara, MF; Luna-Moreno, D; López, JDS; Guillén-Quintero, DM; Vega, J; Duran-Coyote, S; Guerra-García, MT; Durán-Gómez, M; Vigueras-Hernández, A; Ramírez-Jiménez, ME; Grajeda-González, SL; Ramos-Galicia, EM; Ramirez-Carrillo, MF; Fernandez-Ruiz, J; Chirino-Perez, A; Romero-Molina, AO; Zavaleta, DAF; Jaramillo, MAM; Lopez, KJP; Incontri-Abraham, D; Rosado, WN; Catalan, MA; Aguilar, SEV; Zamudio, IPM; Ruiz-Ruiz, E; Garcia, KDC; Guerrero, CV; Martinez, AIR; Moscoso-Sanchez, R; Mancilla, MDR; Villa, A; Luna-Ramirez, SA; Hernández-Hernández, S; Frias, E; Campos, A; Morales-Sosa, PA; Toxqui-Merchant, LE; García, K; Pasaniuc, B; Butte, MJ; Geschwind, DH; Aguilar-Salinas, CA; Heidecker, B; Kurth, F; Sander, LE; Skurk, C; Landmesser, U; Karadeniz, Z; Wang, XM; Poller, W; Suwalski, P; Ripke, S; Braun, A; Kraft, J; Mayer, A; Lippert, LJ; Helbig, ET; Thibeault, C; Awasthi, S; Mbarek, H; Ismail, SI; Saad, C; Al-Sarraj, Y; Badji, RM; Al-Muftah, W; Al Thani, A; Afifi, N; Sadiq, F; Khan, MI; Bhutta, MJ; Khan, H; Khan, M; Ain, Q; Junaid, A; Khan, EA; Sypniewski, M; Lejman, A; Zawadzki, P; Kaja, E; Sztromwasser, P; Król, Z; Dobosz, P; Stojak, J; Flores, C; Carracedo, A; Aguilar, C; Arana-Arri, E; Arranz, MJ; Baptista-Rosas, RC; Bezerra, JF; Bezerra, MAC; Brugada, R; Bustos, M; Calderón, EJ; Castano, L; Conde-Vicente, R; Cordero-Lorenzana, ML; De Martino-Rodríguez, A; Domínguez-Garrido, E; Fariñas, MC; Gil-Fournier, B; Herrero, MJ; Lattig, MC; Martin-López, C; Martín, V; Martinez-Nieto, O; Martinez-Lopez, I; Mazzeu, JF; Macías, EM; Cuerda, VM; Silbiger, VN; Oliveira, SF; Parellada, M; Santos, NPC; Pérez-Matute, P; Perez, P; Perucho, T; Porras-Hurtado, GL; Pujol, A; Fernández-Rodríguez, A; Jimenez-Sousa, MA; Rodríguez-Ruiz, E; Rodriguez-Artalejo, F; Rodriguez-Garcia, JA; Ruiz-Cabello, F; Soria, JM; Tamayo, E; Teper, A; Torres-Tobar, L; Urioste, M; Yáñez, Z; Zarate, R; Guillen-Navarro, E; Ayuso, C; González-Neira, A; Riancho, JA; Rojas-Martinez, A; Lapunzina, P; Cruz, R; Diz-de Almeida, S; Ceballos, FC; Lorenzo-Salazar, JM; González-Montelongo, R; Quintela, I; Pita, G; Gago-Domínguez, M; Porras, MS; Tenorio-Castaño, JA; Nevado, J; Aguado, JM; Aguilera-Albesa, S; Almadana, V; Almoguera, B; Alvarez, N; Andreu-Bernabeu, A; Arango, C; Artiga, MJ; Barreda-Sánchez, M; Belhassen-Garcia, M; Boix-Palop, L; Brion, M; Carbonell, C; Castelao, JE; Cortes-Sanchez, JL; Corton, M; Darnaude, MT; del Campo-Pérez, V; de Bustamante, AD; Luchessi, AD; Eiros, R; Sanabria, GME; Fernández-Robelo, U; Fernández-Villa, T; Gómez-Arrue, J; Alvarez, BG; de Quiros, FGB; González-Peñas, J; Gutiérrez-Bautista, JF; Herrero-Gonzalez, A; Borja, AL; Lopez-Rodriguez, R; Mancebo, E; Martinez-Resendez, MF; Martinez-Perez, A; Minguez, P; Ortega-Paino, E; Paz-Artal, E; Pérez-Tomás, ME; Pinsach-Abuin, M; Pompa-Mera, EN; León, SR; Resino, S; Fernandes, MR; Ruiz-Hornillos, J; Ryan, P; Souto, JC; Tamayo-Velasco, A; Taracido-Fernandez, JC; Valencia-Ramos, J; de Heredia, ML; Pedersen, OB; Erikstrup, C; Ostrowski, SR; Banasik, K; Brunak, S; Feenstra, B; Stefansson, K; Mikkelsen, S; Sorensen, E; Ullum, H; Westergaard, D; Burgos, C; Andersen, S; Brugdorf, K; Hansen, TF; Hjalgrim, H; Jemec, GB; Nyegaard, M; Werge, T; Johansson, PI; Didriksen, M; Geller, F; Schwinn, M; Jacobsen, RL; Hindhede, L; Rostgaard, K; Gudbjartsson, D; Stefánsson, H; Thorsteinsdóttir, U; Nielsen, KR; Bruun, MT; Dinh, KM; Larsen, MAH; Sækmose, SG; Niemi, MEK; Zeberg, H; Cordioli, M; Pigazzini, S; Nkambul, L; Frithiof, R; Hultström, M; Lipcsey, M; Tardif, N; Rooyackers, O; Grip, J; Maricic, T; Heid, IM; Wagner, R; Überla, K; Winkler, TW; Wiegrebe, S; Gorski, M; Stark, KJ; Peterhoff, D; Einhauser, S; Niller, HH; Beileke, S; Johnson, R; Pasaniuc, B; Butte, MJ; Freimer, N; Butte, MJ; Geschwind, DH; Pasaniuc, B; Ding, Y; Chiu, A; Chang, TS; Boutros, P; Nakanishi, T; Karczewski, KJ; Martin, AR; Wilson, DJ; Spencer, CCA; Crook, DW; Wyllie, DH; O'Connell, AM; Richards, JB; Butler-Laporte, G; Forgetta, V; Atkinson, EG; Kanai, M; Tsuo, K; Baya, N; Turley, P; Gupta, R; Walters, RK; Palmer, DS; Sarma, G; Solomonson, M; Cheng, N; Lu, WH; Churchhouse, C; Goldstein, JI; King, D; Zhou, W; Seed, C; Daly, MJ; Neale, BM; Finucane, H; Bryant, S; Satterstrom, FK; Band, G; Earle, SG; Lin, SK; Arning, N; Koelling, N; Armstrong, J; Rudkin, JK; Callier, S; Bryant, S; Cusick, C; Fernandez-Cadenas, I; Planas, AM; Perez-Tur, J; Llucià-Carol, L; Cullell, N; Muiño, E; Cárcel-Márquez, J; DeDiego, ML; Iglesias, LL; Soriano, A; Rico, V; Agüero, D; Bedini, JL; Lozano, F; Domingo, C; Robles, V; Ruiz-Jaén, F; Márquez, L; Gomez, J; Coto, E; Albaiceta, GM; García-Clemente, M; Dalmau, D; Arranz, MJ; Dietl, B; Serra-Llovich, A; Soler-Palacin, P; Colobran, R; Martin-Nalda, A; Parra-Martínez, A; Bernardo, D; Rojo, S; Fiz-López, A; Arribas-Rodriguez, E; Cal-Sabater, P; Segura, T; González-Villar, E; Serrano-Heras, G; Martí-Fàbregas, J; Jiménez-Xarrié, E; Mimbrera, AD; Masjuan, J; García-Madrona, S; Domínguez-Mayoral, A; Villalonga, JM; Menéndez-Valladares, P; Solomonson, M

    NATURE   621 ( 7977 )   E7 - +   2023年9月   ISSN:0028-0836 eISSN:1476-4687

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  • Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

    Edahiro, R; Shirai, Y; Takeshima, Y; Sakakibara, S; Yamaguchi, Y; Murakami, T; Morita, T; Kato, Y; Liu, YC; Motooka, D; Naito, Y; Takuwa, A; Sugihara, F; Tanaka, K; Wing, JB; Sonehara, K; Tomofuji, Y; Namkoong, H; Tanaka, H; Lee, H; Fukunaga, K; Hirata, H; Takeda, Y; Okuzaki, D; Kumanogoh, A; Okada, Y; Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Tanaka, H; Lee, H; Saiki, R; Hyugaji, T; Shimizu, E; Katayama, K; Kanai, M; Naito, T; Sasa, N; Yamamoto, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Ichikawa, M; Nakamura, A; Harada, S; Sandhu, Y; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Shiroyama, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Tomono, K; Kato, K; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, STS; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Koji, S; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, HRYS; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Takano, T; Katayama, K; Ai, MSM; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K

    NATURE GENETICS   55 ( 5 )   753 - +   2023年5月   ISSN:1061-4036 eISSN:1546-1718

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    出版者・発行元:Nature Genetics  

    Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 healthy controls of Japanese ancestry with host genetic data. COVID-19 patients showed a low fraction of nonclassical monocytes (ncMono). We report downregulated cell transitions from classical monocytes to ncMono in COVID-19 with reduced CXCL10 expression in ncMono in severe disease. Cell–cell communication analysis inferred decreased cellular interactions involving ncMono in severe COVID-19. Clonal expansions of BCR were evident in the plasmablasts of patients. Putative disease genes identified by COVID-19 genome-wide association study showed cell type-specific expressions in monocytes and dendritic cells. A COVID-19-associated risk variant at the IFNAR2 locus (rs13050728) had context-specific and monocyte-specific expression quantitative trait loci effects. Our study highlights biological and host genetic involvement of innate immune cells in COVID-19 severity.

    DOI: 10.1038/s41588-023-01375-1

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  • Platypnea-Orthodeoxia Syndrome in Coronavirus Disease 2019 Pneumonia: A Case Report and Literature Review 査読

    Tanimoto, T; Eriguchi, Y; Sato, T; Yonekawa, A; Miyake, N; Akashi, K; Shimono, N

    INTERNATIONAL MEDICAL CASE REPORTS JOURNAL   16   201 - 207   2023年3月   ISSN:1179-142X

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Medical Case Reports Journal  

    Platypnea-orthodeoxia syndrome (POS) is a rare disorder associated with coronavirus disease 2019 (COVID-19) pneu-monia. However, POS may be underdiagnosed. We report the case of a 59-year-old female patient with POS complicated by pulmonary embolism in COVID-19. Imaging revealed ground-glass opacities predominantly in the lower lobes and a pulmonary embolus in the right upper lobe. She was diagnosed with POS due to marked postural discrepancies between supine and upright oxygen saturations and blood oxygenation. Intracardiac shunt, one of the etiologies of POS, was not detected by bubble contrast echocardiography, and postural de-saturation gradually improved with methylprednisolone and edoxaban administration. In our literature review, only 3 of the 16 patients with POS associated with COVID-19 had cardiac shunting, suggesting that moderate to severe COVID-19 causes POS without cardiac shunts. COVID-19-associated vasculopathy and lower lung lesion predominance in COVID-19 pneumonia may cause ventilation-perfusion mismatch due to gravitational shunting of blood into the poorly ventilated lower lungs in the upright position, which may ultimately cause POS. Hypoxemia impedes rehabilitation, whereas early initiation of supine positioning in bed, with knowledge of the pathophysiology of POS, may have a positive effect.

    DOI: 10.2147/IMCRJ.S402537

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  • <i>DOCK2</i> is involved in the host genetics and biology of severe COVID-19 査読

    Namkoong, H; Edahiro, R; Takano, T; Nishihara, H; Shirai, Y; Sonehara, K; Tanaka, H; Azekawa, S; Mikami, Y; Lee, H; Hasegawa, T; Okudela, K; Okuzaki, D; Motooka, D; Kanai, M; Naito, T; Yamamoto, K; Wang, QBS; Saiki, R; Ishihara, R; Matsubara, Y; Hamamoto, J; Hayashi, H; Yoshimura, Y; Tachikawa, N; Yanagita, E; Hyugaji, T; Shimizu, E; Katayama, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Aoki, R; Nakamura, A; Harada, S; Sasano, H; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Suzuki, K; Naito, Y; Liu, YC; Takuwa, A; Sugihara, F; Wing, JB; Sakakibara, S; Hizawa, N; Shiroyama, T; Miyawaki, S; Kawamura, Y; Nakayama, A; Matsuo, H; Maeda, Y; Nii, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Kishikawa, T; Yamada, S; Kawabata, S; Kijima, N; Takagaki, M; Sasa, N; Ueno, Y; Suzuki, M; Takemoto, N; Eguchi, H; Fukusumi, T; Imai, T; Fukushima, M; Kishima, H; Inohara, H; Tomono, K; Kato, K; Takahashi, M; Matsuda, F; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, S; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Sakamoto, K; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, H; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Katayama, K; Ai, M; Fukui, Y; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K; Okada, Y

    NATURE   609 ( 7928 )   754 - +   2022年9月   ISSN:0028-0836 eISSN:1476-4687

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature  

    Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1–5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.

    DOI: 10.1038/s41586-022-05163-5

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  • The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force 査読

    Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Tanaka, H; Lee, H; Saiki, R; Hyugaji, T; Shimizu, E; Katayama, K; Kanai, M; Naito, T; Sasa, N; Yamamoto, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Ichikawa, M; Nakamura, A; Harada, S; Sandhu, Y; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Shiroyama, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Tomono, K; Kato, K; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, S; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Koji, S; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, H; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Takano, T; Katayama, K; Ai, M; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K; Okada, Y

    NATURE COMMUNICATIONS   13 ( 1 )   4830   2022年8月   ISSN:2041-1723 eISSN:2041-1723

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature Communications  

    Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.

    DOI: 10.1038/s41467-022-32276-2

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  • A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections. 国際誌

    Scientific reports   11 ( 1 )   23447 - 23447   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-021-02619-y

  • Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19. 国際誌

    Hiromu Tanaka, Ho Lee, Atsuho Morita, Ho Namkoong, Shotaro Chubachi, Hiroki Kabata, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   113   74 - 81   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijid.2021.09.070

  • p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. 国際誌

    Keane K Y Lai, Xiaohui Hu, Keisuke Chosa, Cu Nguyen, David P Lin, Keith K Lai, Nobuo Kato, Yusuke Higuchi, Sarah K Highlander, Elizabeth Melendez, Yoshihiro Eriguchi, Patrick T Fueger, Andre J Ouellette, Nyam-Osor Chimge, Masaya Ono, Michael Kahn

    Cancers   13 ( 6 )   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/cancers13061288

  • Inhibition of Stearoyl-CoA Desaturase Induces the Unfolded Protein Response in Pancreatic Tumors and Suppresses Their Growth. 国際誌

    Kaitlin Skrypek, Steven Balog, Yoshihiro Eriguchi, Kinji Asahina

    Pancreas   50 ( 2 )   219 - 226   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPA.0000000000001737

  • Clinical significance of SARS-CoV-2-specific IgG detection with a rapid antibody kit for COVID-19 patients. 国際誌

    Yong Chong, Hideyuki Ikematsu, Naoki Tani, Yoko Arimizu, Haruka Watanabe, Yukako Fukamachi, Akiko Yonekawa, Sho Iwasaka, Ruriko Nishida, Yoshihiro Eriguchi, Noriko Miyake, Shinji Shimoda, Yoji Nagasaki, Nobuyuki Shimono, Koichi Akashi

    Influenza and other respiratory viruses   15 ( 1 )   13 - 18   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/irv.12802

  • Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms 査読

    Scientific reports   9 ( 1 )   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-019-53402-z

  • Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency 査読

    Eduardo R. Cobo, Ravi Holani, France Moreau, Kiminori Nakamura, Tokiyoshi Ayabe, Jennifer R. Mastroianni, Yoshihiro Eriguchi, Andre Ouellette, Kris Chadee

    Infection and Immunity   86 ( 7 )   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1128/IAI.00208-18

  • Decreased secretion of Paneth cell α-defensins in graft-versus-host disease 査読

    17 ( 5 )   702 - 706   2015年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Intestinal microbial ecology is actively regulated by Paneth cell-derived antimicrobial peptides, α-defensins. Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (SCT). We previously demonstrated that Paneth cells are targeted by GVHD, and their expression of antimicrobial peptide α-defensins is impaired, leading to a loss of physiological diversity among the microflora and development of bloodstream infection. Herein, we evaluated whether fecal levels of α-defensins could be surrogate marker of intestinal dysbiosis. Methods: We directly measured α-defensin cryptdin-1 (Crp1) in fecal pellets of mice with GVHD by using a novel enzyme-linked immunosorbent assay. Results: Fecal levels of Crp1 were significantly decreased in mice with GVHD but unchanged in mice without GVHD after SCT. These were correlated with intestinal flora diversity. Conclusion: We demonstrate a link between reduced secretion of Paneth cell α-defensins and dysbiosis of intestinal flora in GVHD. Fecal levels of α-defensins could be surrogate markers for intestinal microbial homeostasis.

    DOI: 10.1111/tid.12423

  • Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease 査読

    Yoshihiro Eriguchi, Hidetaka Uryu, Kiminori Nakamura, Sonoko Shimoji, Shuichiro Takashima, Hiromi Iwasaki, Toshihiro Miyamoto, Nobuyuki Shimono, Daigo Hashimoto, Koichi Akashi, Tokiyoshi Ayabe, Takanori Teshima

    Biology of Blood and Marrow Transplantation   19 ( 10 )   1525 - 1529   2013年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbmt.2013.07.027

  • Evaluating the association between histological manifestations of cord colitis syndrome with GVHD 査読

    S. Shimoji, K. Kato, Y. Eriguchi, K. Takenaka, H. Iwasaki, T. Miyamoto, Y. Oda, K. Akashi, T. Teshima

    Bone Marrow Transplantation   48 ( 9 )   1249 - 1252   2013年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/bmt.2013.44

  • Influence of inoculum size on MICs for methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus on in vitro 査読

    Noriko Miyake, Masako Kadowaki, Yoriko Sato, Yoshihiro Eriguchi, Yoji Nagasaki, Yukiko Harada, Yujiro Uchida, Nobuyuki Shimono

    Japanese Journal of Antibiotics   64 ( 4 )   231 - 237   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors 査読

    Yujiro Uchida, Tomomi Mochimaru, Yuiko Morokuma, Makiko Kiyosuke, Masako Fujise, Fujiko Eto, Yoshihiro Eriguchi, Yoji Nagasaki, Nobuyuki Shimono, Dongchon Kang

    International Journal of Antimicrobial Agents   35 ( 5 )   444 - 450   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijantimicag.2009.12.012

  • Hematological unit invasive aspergillosis epidemiology 査読

    Yoriko Maehara, Yoji Nagasaki, Masako Kadowaki, Yoshihiro Eriguchi, Noriko Miyake, Yujiro Uchida, Koji Nagafuji, Nobuyuki Shimono

    84 ( 2 )   176 - 181   2010年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11150/kansenshogakuzasshi.84.176

  • Combination therapy with micafungin and amphotericin B for invasive pulmonary aspergillosis in an immunocompromised mouse model 査読

    Yoji Nagasaki, Yoshihiro Eriguchi, Yujiro Uchida, Noriko Miyake, Yoriko Maehara, Masako Kadowaki, Mine Harada, Koichi Akashi, Nobuyuki Shimono

    Journal of Antimicrobial Chemotherapy   64 ( 2 )   379 - 382   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jac/dkp175

  • Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus 査読

    Noriko Tsuchimochi, Yujiro Uchida, Yoji Nagasaki, Yoshihiro Eriguchi, Yoriko Maehara, Masako Kadowaki, Nobuyuki Shimono

    Japanese Journal of Chemotherapy   55 ( 5 )   363 - 367   2007年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Rabeprazole-based eradication therapy for Helicobacter pylori A large-scale study in Japan 査読

    H. Kuwayama, K. Asaka, T. Sugiyama, Y. Fukuda, N. Aoyama, Y. Hirai, T. Fujioka, Gakuyo Karasawa, Ryo Uyama, Mototsugu Kato, Yuichi Shimizu, Souichi Nakagawa, Ken Nishi, Shigeru Ozasa, Mineo Kudo, Takahiro Kamata, Masao Saito, Naoyuki Kawamura, Masako Tsuyuguchi, Hiroko Ooizumi, Takeaki Kobayashi, Asako Iijima, Tsuyoshi Yabana, Kazuyoshi Yamashita, Youji Harada, Teitetsu Niido, Yuri Yasuda, Yoko Iga, Hajime Kuwayama, Morio Takahashi, Hironobu Takada, Hiroshi Takada, Shigeki Oka, Hiroki Ichimura, Eiko Makino, Kazumasa Miki, Jun Miwa, Yasuo Matsubara, Takashige Tomita, Shigeru Koyama, Nobuhiro Sakaki, Masahiko Takahashi, Haruko Yokoyama, Yuji Koike, Tuyo To, Yoshiharu Satake, Makiyo Machida, Takashi Kawai, Satoru Taira, Kenji Nukaga, Naomi Uemura, Jyunichi Akiyama, Yuko Hiraga, Hitohiko Koizuka, Shigeaki Yasaka, Ryosuke Tajiri, Masao Kobayakawa, Akitaka Takahara, Mika Shimamoto, Hiroshi Murata, Toshihide Okada, Yoshihide Fujiyama, Shigeki Koyama, Masaya Sasaki, Tomoyuki Tsujikawa, Izumi Ishizuka, Kiyoshi Ashida, Hajime Takahashi, Takumi Fukuchi, Naomi Kiyota, Hiroshi Yamashita, Reiko Tsukamoto, Hiroshi Ito, Tomohiro Nishide, Haruki Kato, Takashi Ando, Koichi Terao, Nobuo Aoyama, Daisuke Shirasaka, Takao Tamura, Shunichi Yoshida, Seiichi Hirano, Yoshihiro Fukuda, Kazutoshi Hori, Toshihiko Tomita, Tahashi Sakagami, Kazuhiko Inoue, Mutsumi Hananoki, Norio Miyashima, Hirotsugu Okuda, Kazuhiro Harada, Toshihiro Honda, Masaharu Takeda, Ken Haruma, Toru Hidaka, Hiroaki Oogoshi, Shinji Nagata, Akira Tari, Hiroshi Tani, Hiroshi Mieno, Mitsuhiro Mihara, Yoshihiro Wada, Tomohiko Shimatani, Masaki Inoue, Takashi Kobayashi, Kazuhiko Yamauchi, Makoto Tsugita, Nobutoshi Kuniyoshi, Kazuma Fujimoto, Ryuichi Iwakiri, Hiroyuki Sakata, Seiji Tsunada, Akifumi Ootani, Atsushi Kikkawa, Yoshihiro Eriguchi, Koji Fukuyama, Masahiro Hattori, Tomofumi Tanaka, Kiwamu Hasuda, Hideyo Goto, Toshio Fujioka, Ryugo Sato, Kazunari Murakami, Masaaki Kodama, Tadayoshi Okimoto, Hajime Miyajima, Masami Ono, Tsuyoshi Arita, Syunzo Sato, Hisanori Abe

    Alimentary Pharmacology and Therapeutics   25 ( 9 )   1105 - 1113   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1365-2036.2007.03298.x

  • A case of relapsed ischemic colitis with colon cast-like stripped mucosa 査読

    Yoshihiro Eriguchi, Seiji Tsunada, Sadahiro Amemori, Kenichiro Watanabe, Takehiro Fujise, Atsushi Kikkawa, Hibiki Ootani, Akifumi Ootani, Hiroyuki Sakata, Ryuichi Iwakiri, Masanobu Mizuguchi, Kazuma Fujimoto

    Japanese Journal of Gastroenterology   103 ( 10 )   1152 - 1156   2006年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物

  • 腸管微小環境とGVHD

    江里口芳裕( 担当: 単著)

    科学評論社  2013年6月 

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    担当ページ:月刊血液内科 66巻6号; p762-768   記述言語:日本語   著書種別:学術書

  • 移植片対宿主病はPaneth細胞の傷害を介して腸内環境を破綻させる

    江里口芳裕( 担当: 単著)

    メディカルレビュー社  2013年3月 

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    担当ページ:Trends in Hematological Malignancies Vol.5 No.1, p22-25   記述言語:日本語   著書種別:一般書・啓蒙書

  • 症例とエビデンスに学ぶ 造血細胞移植と感染症

    豊嶋崇徳、大島久美、神田善伸、角南一貴、日野雅之、澤正史、福原敬、竹中克斗、角川康夫、福田隆浩、櫻井政寿、岡本真一郎、名和由一郎、高橋義行、吉川哲史、緒方正男、星研一、植木俊光、小林光、石山謙、中尾眞二、和氣敦、石綿一哉、宮本敏弘、秋山秀樹、渡部昌実、柴崎康彦、古川達雄、長藤宏司、森尾友宏、井上雅美、加藤元博、花田良二、高見昭良、松本公一、加藤剛二、池亀和博、竹本雅子、川上学、中川雅史、衛藤徹也、荒岡秀樹、加古真一、加藤せい子、高橋聡、森慎一郎、吾郷浩厚、小林良二、亀井克彦、渡辺哲、森有紀、芦澤和人、金森平和、太田秀一、加藤光次( 担当: 共著)

    医薬ジャーナル社  2011年8月 

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    記述言語:日本語   著書種別:一般書・啓蒙書

講演・口頭発表等

  • Interferon-γ Induces Paneth Cell Loss in Mouse Ileum Enteroid Cultures. 国際会議

    2017年2月 

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    開催年月日: 2020年7月

    記述言語:英語  

    開催地:Ventura, CA   国名:アメリカ合衆国  

  • 妊娠中期に激烈な経過をとったA群溶連菌(GAS)感染症の1剖検例

    江里口芳裕、李守永、藤村直幸、杉森宏、橋爪誠、矢幡秀昭、和氣徳夫

    第39回日本集中治療医学会  2012年2月 

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    開催年月日: 2012年2月

    会議種別:シンポジウム・ワークショップ パネル(公募)  

    開催地:千葉 幕張メッセ   国名:日本国  

    妊娠中の劇症型GAS感染症は、しばしば感染巣の同定が困難である。特に「劇症分娩型」は妊娠末期の分娩前後の進行が急激で、致命率が高い。我々は、妊娠18週に発症し、劇症分娩型に類似した病像を呈した例を経験したので報告する。 症例:35歳女性、妊娠・分娩歴:G2P1 現病歴:5月上旬にGAS感染症と診断、CTRX3日間投与と3世代経口セフェム薬で改善。5月27日より咽頭痛、29日に39度の発熱と倦怠感が出現し、通院中の産婦人科に昼頃受診。軽度咽頭発赤と尿潜血を認め、CFPN-PI処方され帰宅。17時より下腹部痛増強し同医再診、19時FMOX投与後に胎児死亡となり、緊急搬送。20時30分の来院時より徐々に呼吸状態悪化、22時の胸部X線で肺胞出血が疑われ、またMOFと診断。23時10分ICU入室し、人工呼吸管理、ABPC+MEPM、Nad/Adr+DOB、rTM+AT- IIIの投与、CHDF/PMX、RCC/FFP/PC輸血、IVIG行うも翌6時44分死亡。血液培養よりGAS検出されたが、剖検上、原発巣同定は困難だった。

  • GVHDにおける腸内環境 招待

    江里口芳裕

    第16回九州骨髄移植カンファレンス  2011年11月 

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    開催年月日: 2011年11月

    会議種別:口頭発表(一般)  

    開催地:福岡   国名:日本国  

    1970年代の骨髄移植治療の黎明期にグラム陰性桿菌敗血症の発症が多いことが報告されており、現在では、予防内服が死亡率の改善を示したことから、骨髄移植に伴うグラム陰性桿菌敗血症のメカニズムは未解明のまま、抗菌薬の予防投与が一般的である。  我々はこの病態が、腸内細菌の腸管からのbacterial translocationによると考え、そのメカニズムを解明するために、骨髄移植によるGVHDモデルマウスを使用し検討した結果を報告する。

  • 劇症型A群溶連菌感染症の1症例

    江里口 芳裕、李 守永、藤村 直幸、大川 彦宏、矢幡 秀昭、橋爪 誠

    感染症フォーラム2011 in 九州  2011年8月 

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    開催年月日: 2011年8月

    会議種別:口頭発表(一般)  

    開催地:福岡   国名:日本国  

  • 造血幹細胞移植の新たな感染対策

    江里口芳裕、前原依子、下野信行、宮本敏浩、赤司浩一、豊嶋崇徳

    第44 回 日本無菌生物ノートバイオロジー学会総会  2011年1月 

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    開催年月日: 2011年1月

    会議種別:シンポジウム・ワークショップ パネル(公募)  

    開催地:札幌   国名:日本国  

  • Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting production of enteric defensins. 国際会議

    Yoshihiro Eriguchi, Shuichiro Takashima, Noriko Miyake, Yoji Nagasaki, Nobuyuki Shimono, Koichi Akashi, and Takanori Teshima

    52nd ASH Annual Meeting and Exposition  2010年12月 

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    開催年月日: 2010年12月

    会議種別:口頭発表(一般)  

    国名:アメリカ合衆国  

    Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting production of enteric defensins.

  • 内視鏡により止血しえた回盲部Dieulafoy潰瘍の2例

    江里口芳裕 馬場英司 竹山泰守 矢野正浩

    第87回日本消化器内視鏡学会九州支部例会  2009年6月 

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    開催年月日: 2009年6月

    会議種別:口頭発表(一般)  

    開催地:福岡   国名:日本国  

  • ヘルペス腸炎に偽膜性腸炎を併発した血管型ベーチェット病の1症例

    江里口芳裕、隅田幸祐、長崎洋司、馬場英司、塚本浩、下野信行、赤司浩一、伏見文良、田宮貞史、小田義直

    第87回日本消化器内視鏡学会九州支部例会  2009年6月 

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    開催年月日: 2009年6月

    会議種別:口頭発表(一般)  

    開催地:福岡   国名:日本国  

  • 急性GVHDと腸内細菌叢バランスによる相互作用

    江里口芳裕、高嶋秀一郎、門脇雅子、原田由紀子、長崎洋司、三宅典子、豊嶋崇徳、 下野 信行、赤司浩一

    第83回感染症学会総会  2009年5月 

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    開催年月日: 2009年5月

    会議種別:口頭発表(一般)  

    国名:日本国  

  • Graft-Versus-Host Disease Targets Ovary and Causes Infertility After Allogeneic Hematopoietic Stem Cell Transplantation. 国際会議

    Shimoji S, Kato K, Tsujigiwa H, Eriguchi Y, Lee L, Uryu H, Takashima S, Hashimoto D, Akashi K, and Teshima T

    55th ASH Annual Meeting and Exposition  2013年12月 

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    開催年月日: 2020年12月 - 2013年12月

    記述言語:英語  

    国名:アメリカ合衆国  

  • Listeria monocytogenesによる感染性心内膜炎の一例

    岩坂翔,上原晶子,中嶋舞,門脇雅子,江里口芳裕,内田勇二郎,下野信行

    第81回日本感染症学会西日本地方会学術集会  2011年10月 

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    開催年月日: 2011年10月

    会議種別:口頭発表(一般)  

    開催地:北九州   国名:日本国  

  • 同種臍帯血移植まで行ったが救命できなかった慢性活動性EBウイルス感染症(CAEBV)の1例

    斧沢京子,長崎洋司,岩崎教子,隅田幸祐,原田由紀子,門脇雅子,江里口芳裕,内田勇二郎,下野信行

    第81回日本感染症学会西日本地方会学術集会  2011年10月 

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    開催年月日: 2011年10月

    会議種別:口頭発表(一般)  

    国名:日本国  

  • 当院でのカンジダ眼内炎についての考察

    門脇雅子,長崎洋司,三宅典子,江里口芳裕,斧沢京子,岩崎教子,内田勇二郎,下野信行

    第81回日本感染症学会西日本地方会学術集会  2011年10月 

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    開催年月日: 2011年10月

    会議種別:口頭発表(一般)  

    開催地:北九州   国名:日本国  

  • 当院のCOVID-19に罹患した造血器悪性腫瘍患者におけるウイルス排出期間と臨床像に関する検討

    米川 晶子, 三宅 典子, 江里口 芳裕, 西田 留梨子, 鄭 湧, 下野 信行

    感染症学雑誌  2024年3月  (一社)日本感染症学会

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    記述言語:日本語  

▼全件表示

所属学協会

  • 日本内科学会

  • 日本消化器病学会

  • 日本環境感染学会

  • 日本化学療法学会

  • 日本救急医学会

  • 日本感染症学会

  • 日本消化器内視鏡学会

  • 腸内細菌学会

      詳細を見る

  • 日本環境感染学会

      詳細を見る

  • 日本消化管学会

      詳細を見る

  • 日本消化器病学会

      詳細を見る

  • 日本消化器内視鏡学会

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  • 日本救急医学会

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  • 日本感染症学会

      詳細を見る

  • 日本化学療法学会

      詳細を見る

▼全件表示

学術貢献活動

  • 学術論文等の審査

    役割:査読

    2023年

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    種別:査読等 

    外国語雑誌 査読論文数:1

    日本語雑誌 査読論文数:0

    国際会議録 査読論文数:0

    国内会議録 査読論文数:0

  • シンポジスト

    第44回日本無菌生物ノートバイオロジー学会総会  ( 札幌 ) 2011年1月

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    種別:大会・シンポジウム等 

共同研究・競争的資金等の研究課題

  • 自己免疫疾患における加齢性クローナル造血の関連についての検討

    研究課題/領域番号:22K08565  2022年4月 - 2025年3月

    科学研究費助成事業  基盤研究(C)

    小野 伸之, 前田 高宏, 江里口 芳裕, 仙波 雄一郎

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    資金種別:科研費

    本研究では加齢性クローナル造血(clonal hematopoiesis: CH)と自己免疫疾患発症との関連を解明する。CHは加齢による体細胞変異を有しながら、 悪性化していない造血細胞を指す。CHは血液腫瘍発症のリスクとなり重要であるが、近年 CH由来の細胞がinflammagingを誘導し、動脈硬化性疾患発症に関わっていることがわかった。 我々はCHによるinflammagingが高齢発症自己免疫疾患の病態でも重要な役割を果たすと仮説 し、本研究を立案した。CHが関わる自己免疫疾患を同定し、CHがどのような免疫異常を誘導し、発症に関わるかを解明する。

    CiNii Research

  • 腸管移植片対宿主病におけるバクテリアルトランスロケーションの病態解明

    研究課題/領域番号:20K17465  2020年 - 2023年

    日本学術振興会  科学研究費助成事業  若手研究

    江里口 芳裕

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    担当区分:研究代表者  資金種別:科研費

    造血幹細胞移植後の腸管からのバクテリアルトランスロケーションによる敗血症は、致死 的な合併症であり、治療成績を大きく左右する。移植周術期の抗菌薬による腸管内殺菌等の 試みにより治療成績は改善したが、長期の抗菌薬投与は耐性菌の定着を促し、治療に難渋す る耐性菌感染症が問題となっている。今までは、無菌室や腸管内殺菌など、環境や病原体に 関わる宿主外の因子に焦点が当てられてきたが、これでは多剤耐性菌の問題は解決できない。 本研究では、従来研究されてきた病原体因子ではなく、宿主因子である病原体の侵入門戸に焦点を当て、新規治療法の開発を行う。

    CiNii Research

  • Graft-Versus-Host-Diseaseにおける腸管組織の抗菌物質発現に関する疫学的調査

    2011年5月 - 2016年3月

    九州大学 

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    担当区分:研究分担者 

    造血器悪性腫瘍に対する造血幹細胞移植後の腸管GVHDは重大な合併症であり、腸管上皮の障害により腸管の抗菌ペプチドの発現量に大きな変化が起こることが予想される。
    我々は、GVHDマウスモデルにて、腸管GVHD発症により、腸管組織での抗菌ペプチドのmRNA発現量が変化し、それとともに、腸内細菌叢が大きく変化することを突き止めた。また、正常腸内細菌叢は偏性嫌気性菌である共生菌が主体であるが、腸管GVHD発症時は、病原性の高い大腸菌が最優勢菌となり、その大腸菌が腸管からtranslocationすることを明らかにした。
    大腸菌のようなグラム陰性桿菌による感染症はGVHDを悪化させることが知られており、また、日常診療では、このようなグラム陰性桿菌感染症がGVHD発症後の致死的な合併症となるが、この実際の病態については知られていない。我々は、このような病態を解明すべく、病理組織診断時に採取された腸管組織における抗菌ペプチドの発現を評価し、関連する臨床項目についてカルテを調べ、後方視的に調査することを計画した。

  • 造血器悪性腫瘍患者における腸内細菌叢に関する疫学的調査

    2011年5月 - 2016年3月

    九州大学病院 

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    担当区分:研究分担者 

    造血器悪性腫瘍に対する放射線・化学療法や、造血幹細胞移植後の腸管移植片対宿主病は、腸管上皮を傷害し、腸管免疫の破たんから正常腸内細菌叢が大きく乱されることが予想される。
    我々は、移植片対宿主病マウスモデルにて、腸管移植片対宿主病発症により、腸管組織での抗菌ペプチドのmRNA発現量の変化にともない腸内細菌叢が大きく変化することを突き止めた。また、正常腸内細菌叢は偏性嫌気性菌である共生菌が主体であるが、腸管移植片対宿主病発症時は、病原性の高い大腸菌が最優勢菌となり、その大腸菌が腸管からtranslocationすることを明らかにした。
    大腸菌のようなグラム陰性桿菌による感染症は移植片対宿主病を悪化させることが知られており、また、日常診療では、このようなグラム陰性桿菌感染症が移植片対宿主病発症後の致死的な合併症となるが、この実際の病態については知られていない。我々は、このような病態を解明すべく、造血器悪性腫瘍で治療中に便培養で採取された便検体を用いて、腸内菌叢を評価し、関連する臨床項目についてカルテを調べ、調査することを計画した。

  • GVHDモデルマウスの腸内フローラ変化のメカニズムとGVHDの病態へ及ぼす影響

    2010年 - 2011年

    財団法人ヤクルト・バイオサイエンス研究財団

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    担当区分:研究代表者  資金種別:受託研究

教育活動概要

  • 学生のベッドサイドでの教育、研修医・後期研修医への指導。
    大学院生への研究指導を行っている。
    また、他科へのコンサルテーション、インフェクションコントロールチームとしての教育ラウンドにより、感染症診療の教育活動を行っている。

社会貢献・国際連携活動概要

  • 新型コロナウイルス感染症診療の拠点としての九州大学病院で、感染症専門医として診療に従事している。
    外来及び入院診療にて、難渋する感染症の紹介を受けている。
    海外の研究室との共同研究を継続している。

海外渡航歴

  • 2013年4月 - 2019年8月

    滞在国名1:アメリカ合衆国   滞在機関名1:Keck School of Medicine of USC, Department of Pathology and Laboratory Medicine

学内運営に関わる各種委員・役職等

  • 2023年4月 - 2024年3月   部門 外来医長

専門診療領域

  • 生物系/医歯薬学/内科系臨床医学/消化器内科学

  • 生物系/医歯薬学/内科系臨床医学/膠原病・アレルギー・感染症内科学

  • 生物系/医歯薬学/外科系臨床医学/救急医学

臨床医資格

  • 指導医

    日本感染症学会

  • 認定医

    日本内科学会

  • 専門医

    日本消化器内視鏡学会

  • 専門医

    日本消化器病学会

  • 専門医

    日本救急医学会

医師免許取得年

  • 2001年

特筆しておきたい臨床活動

  • 院内・ICU内での感染管理