Updated on 2024/10/01

Information

 

写真a

 
AYANO MASAHIRO
 
Organization
Kyushu University Hospital Department of Clinical Immunology and Rheumatology / Infectious Disease Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425233
Profile
<研究活動> 全身性エリテマトーデスを対象とした多施設前向き観察研究を行っている。 「寛解期膠原病患者に残存する倦怠感の要因解明と治療戦略の確立」に関する研究を行っている。 <教育活動> ベッドサイド、クリ二カルクラークシップで医学部学生の指導を行っている。 <社会活動> リウマチ・膠原病専門医として九州大学病院で外来・病棟業務を行っている。
External link

Degree

  • PhD

Research Interests・Research Keywords

  • Research theme:Elucidation of the causes of residual fatigue in patients with collagen disease in remission

    Keyword:SLE, fatigue

    Research period: 2023.4 - 2027.3

  • Research theme:Roles of CD226 in the pathogenesis of systemic lupus erythematosus

    Keyword:SLE, CD226, DNAM-1

    Research period: 2019.4 - 2022.3

  • Research theme:The role of CD300a in the pathogenesis of systemic sclerosis

    Keyword:CD300a, "systemic sclerosis"

    Research period: 2016.4 - 2019.3

Papers

  • Comparative efficacy and safety of belimumab and hydroxychloroquine in the maintenance phase in patients with systemic lupus erythematosus: a retrospective cohort study Reviewed

    Koichi Kimura, Masahiro Ayano, Shun-Ichiro Ota, Kazuo Kushimoto, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Frontiers in Lupus   2   2024.9   eISSN:2813-6934

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Objectives

    Hydroxychloroquine (HCQ), a cornerstone drug, is recommended for long-term use in treating systemic lupus erythematosus (SLE). However, in cases where HCQ is unavailable, it is unclear which drugs should be prioritised for continuation. We aimed to clarify whether belimumab (BLM), which has recently been reported to have long-term safety and efficacy, could be a viable alternative to HCQ.

    Methods

    We retrospectively compared the efficacy, drug continuation rate and safety of HCQ and BLM in the maintenance phase in patients with SLE. The efficacy endpoints were the cumulative incidence of flares over 2 years, the increase in the damage index and the changes in the SLE Disease Activity Index 2000 (SLEDAI) score and prednisolone dose. The safety endpoint was the adverse event rates.

    Results

    Among 96 patients analysed, 15 out of 84 patients (17.9%) in the HCQ group and 1 out of 12 patients (8.3%) in the BLM group experienced a flare, with no significant difference in the cumulative incidence of flares between the two groups (p = 0.47). No differences were observed in the cumulative incidence of the increase in the damage index, changes in the SLEDAI score and prednisolone dose, drug continuation rates and adverse events.

    Conclusions

    The efficacy and safety of BLM were similar to those of HCQ. BLM could be a valuable treatment option for patients with SLE as an alternative for those who cannot tolerate HCQ.

    DOI: 10.3389/flupu.2024.1459949

    researchmap

  • Treatment selection in the clinical practice of systemic lupus erythematosus: Results from the Kyushu Collagen Disease Network for Systemic Lupus Erythematosus (KCDN-SLE) registry Reviewed

    Masahiro Ayano, Naoyasu Ueda, Koji Mishima, Shun-Ichiro Ota, Kazuo Kushimoto, Atsushi Tanaka, Shotaro Kawano, Naoya Nishimura, Yusuke Kashiwado, Goro Doi, Tsuyoshi Nakayama, Ryo Fukumoto, Tomomi Tsuru, Midori Suzaki, Mitsuteru Akahoshi, Makiko Maekawa, Aya Omoto, Hitoshi Tada, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Modern Rheumatology   2024.8   ISSN:1439-7595 eISSN:1439-7609

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    Objectives: This study aimed to describe the treatment selection for systemic lupus erythematosus (SLE) using data from the Kyushu Collagen Disease Network for SLE (KCDN-SLE) registry, a multicenter prospective registry in Japan.

    Methods: This study used data from patients registered between August 2022 and November 2023. Clinical characteristics, purpose of agent initiation, other candidate agents, and short-term efficacy and safety were evaluated.

    Results: We analyzed 69 previously treated patients with SLE (mean age 43.7 years; 62 females, 7 males). Hydroxychloroquine, biological agents, and immunosuppressive agents were initiated during the maintenance phase in 12, 41, and 16 patients, respectively. In patients with active organ involvement, hydroxychloroquine and biological agents were widely used for initiation. In those who already achieved treatment goals, biological agents alone were predominantly selected. The SLE Disease Activity Index 2000 score and prednisolone dose declined significantly over a 6-month follow-up period. Among 48 patients with active disease, 22 achieved a lupus low disease activity state, but this had no evident association with the initiation of a biological agent. In total, 14 adverse events, predominantly infections, were observed.

    Conclusions: Biological agents were used preferentially, and the therapeutic agents were appropriately effective and mostly achieved the purpose of agent initiation.

    DOI: 10.1093/mr/roae058

    Web of Science

    PubMed

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  • No clear influence of treatment escalation on flare prevention in serologically active clinically quiescent patients with systemic lupus erythematosus: a retrospective cohort study Reviewed

    Masahiro Ayano, Akie Hirata, Shoji Tokunaga, Hiroko Furuhashi, Yasutaka Kimoto, Nobuyuki Ono, Yojiro Arinobu, Naoki Nakashima, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Rheumatology International   2024.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00296-024-05593-6

  • Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases Reviewed

    M Ayano, K Tsubouchi, K Suzuki, Y Kimoto, Y Arinobu, K Akashi, T Horiuchi, I Okamoto, H Niiro

    Scandinavian Journal of Rheumatology   2024.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/03009742.2024.2327159

  • Complement as a Biomarker for Systemic Lupus Erythematosus Reviewed

    Masahiro Ayano, Takahiko Horiuchi

    Biomolecules   13 ( 2 )   367 - 367   2023.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/biom13020367

  • Safety and efficacy of switching immunosuppressive drugs for maintenance treatment in patients with systemic lupus erythematosus: A retrospective cohort study Reviewed

    Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Modern Rheumatology   2022.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/mr/roac100

  • Comparative efficacy and safety of mizoribine and mycophenolate mofetil for treating systemic lupus erythematosus: a retrospective cohort study Reviewed International journal

    Ayano M, Kimoto Y, Mitoma H, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

    Ther Adv Musculoskelet Dis   14   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1759720X221096367

  • Hydroxychloroquine versus tacrolimus for the treatment of persistently active systemic lupus erythematosus Reviewed International journal

    Ayano M, Kimoto Y, Mitoma H, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

    Mod Rheumatol   32 ( 2 )   345 - 350   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/mr/roab010

  • HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: a retrospective study. Reviewed International journal

    Kushimoto K, Ayano M, Nishimura K, Nakano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

    Arthritis Res Ther.   23 ( 1 )   238   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1186/s13075-021-02618-4.

  • Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus Reviewed International journal

    Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, Mitoma H, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

    Sci Rep.   11 ( 1 )   16162   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41598-021-95711-2.

  • Increased Proportion of CD226+ B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus Reviewed International journal

    Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, Mitoma H, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

    Front Immunol.   12   713225   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.3389/fimmu.2021.713225. eCollection 2021.

  • Shoulder ultrasound and serum lactate dehydrogenase predict inadequate response to glucocorticoid treatment in patients with polymyalgia rheumatica Reviewed International journal

    Masahiro Ayano, Yojiro Arinobu, Hiroshi Tsukamoto, Shun ichiro Ota, Kenta Misaki, Keisuke Nishimura, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Rheumatology International   40 ( 7 )   1101 - 1109   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00296-020-04512-9

  • CD34-selected versus unmanipulated autologous haematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: A post hoc analysis of a phase I/II clinical trial conducted in Japan Reviewed

    Masahiro Ayano, Hiroshi Tsukamoto, Hiroki Mitoma, yasutaka kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Toshihiro Miyamoto, Takahiko Horiuchi, Hiroaki Niiro, Koji Nagafuji, Mine Harada, Koichi Akashi

    Arthritis Research and Therapy   21 ( 1 )   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-019-1823-0

  • Increased CD226 Expression on CD8+ T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis Reviewed International journal

    Masahiro Ayano, Hiroshi Tsukamoto, Kentaro Kohno, Naoyasu Ueda, Atsushi Tanaka, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Takahiko Horiuchi, koichi akashi

    JOURNAL OF IMMUNOLOGY   195 ( 3 )   892 - 900   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1403046

  • Determination of the factors associated with antigen-specific CD4+ T-cell responses to BNT162b2 in patients with rheumatoid arthritis Reviewed

    Fumiaki Sagawa, Hisakata Yamada, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Masakazu Kondo, Yasuharu Nakashima, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    RMD Open   10 ( 1 )   e003693   2024.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/rmdopen-2023-003693

  • Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering Reviewed

    Nobuyuki Ono, Tatsuya Kai, Yukiko Takeyama, Yasushi Inoue, Naoyasu Ueda, Shuji Nagano, Shunichiro Ohta, Hisako Inoue, Takuya Sawabe, Yutaka Chifu, Seiji Yoshizawa, Kensuke Oryoji, Yasutaka Kimoto, Katsuhisa Miyake, Masahiro Ayano, Hiroki Mitoma, Yojiro Arinobu, Tomoya Miyamura, Takahiko Horiuchi, Koichi Akashi, Yoshifumi Tada, Hiroaki Niiro

    Int J Rheum Dis   27 ( 1 )   e15009   2023.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1756-185x.15009

  • Immunosuppressive therapy and humoral response to third mRNA COVID-19 vaccination with a six-month interval in rheumatic disease patients Reviewed

    Yusuke Kashiwado, Yasutaka Kimoto, Shiro Ohshima, Takuya Sawabe, Kensuke Irino, Shota Nakano, Junki Hiura, Akiko Yonekawa, Qiaolei Wang, Goro Doi, Masahiro Ayano, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Hiroaki Niiro, Taeko Hotta, Dongchon Kang, Nobuyuki Shimono, Koichi Akashi, Tsutomu Takeuchi, Takahiko Horiuchi

    Rheumatology   2023.6

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/rheumatology/kead275

  • Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus Reviewed

    Sho Fujimoto, Yojiro Arinobu, Kohta Miyawaki, Masahiro Ayano, Hiroki Mitoma, Yasutaka Kimoto, Nobuyuki Ono, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Rheumatology   2023.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/rheumatology/kead082

  • CEACAM 1, 3, 5 and 6 -positive classical monocytes correlate with interstitial lung disease in early systemic sclerosis Reviewed

    Yokoyama K, Mitoma H, Kawano S, Yamauchi Y, Wang Q, Ayano M, Kimoto Y, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H

    Front Immunol.   13   1016914   2022.10

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  • Antibody response to SARS-CoV-2 mRNA vaccines in patients with rheumatic diseases in Japan: Interim analysis of a multicentre cohort study Reviewed International journal

    Kashiwado Y, Kimoto Y, Sawabe T, Irino K, Nakano S, Hiura J, Wang Q, Kawano S, Ayano M, Mitoma H, Ono N, Arinobu Y, Niiro H, Hotta T, Kang D, Akashi K, Ohshima S, Takeuchi T, Horiuchi T.

    Mod Rheumatol   2022.3

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    Language:English  

    DOI: 10.1093/mr/roac030

  • TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells Reviewed International journal

    Kawano S, Mitoma H, Inokuchi S, Yamauchi Y, Yokoyama K, Nogami J, Semba Y, Ayano M, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

    J Immunol   208 ( 5 )   1057 - 1065   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.2100323

  • Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry Reviewed International journal

    Fujiwara T, Kondo M, Yamada H, Haraguchi A, Fujimura K, Sakuraba K, Kamura S, Fukushi JI, Miyahara H, Inoue Y, Tsuru T, Shuto T, Yoshizawa S, Suematsu E, Miyamura T, Ayano M, Mitoma H, Arinobu Y, Niiro H, Ohishi M, Hirata A, Tokunaga S, Takada A, Hara D, Tsushima H, Akasaki Y, Ikemura S, Sueishi T, Toya M, Sakuragi T, Tsutsui T, Kai K, Arisumi S, Nakashima Y.

    Arthritis Res Ther   24 ( 1 )   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-022-02746-5

  • Predictive factors of fetal and maternal pregnancy outcomes in Japanese patients with systemic lupus erythematosus Reviewed International journal

    Irino K, Arinobu Y, Ayano M, Kawano S, Kimoto Y, Mitoma H, Akahoshi M, Akashi K, Horiuchi T, Niiro H.

    Lupus   30 ( 10 )   1637 - 1643   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1177/09612033211031989.

  • Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs Reviewed International journal

    Takuya Harada, Hiromi Iwasaki, Tsuyoshi Muta, Shingo Urata, Aiko Sakamoto, Kentaro Kohno, Ken Takase, Tomoya Miyamura, Takuya Sawabe, Hideki Asaoku, Kensuke Oryoji, Tomoaki Fujisaki, Yasuo Mori, Goichi Yoshimoto, Masahiro Ayano, Hiroki Mitoma, Toshihiro Miyamoto, Hiroaki Niiro, Hidetaka Yamamoto, Yumi Oshiro, Hiroaki Miyoshi, Koichi Ohshima, Morishige Takeshita, Koichi Akashi, Koji Kato

    Br J Haematol.   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/bjh.17456. Online ahead of print.

  • Autoimmune manifestations associated with myelodysplastic syndrome predict a poor prognosis Reviewed International journal

    Arinobu Y, Kashiwado Y, Miyawaki K, Ayano M, Kimoto Y, Mitoma H, Akahoshi M, Miyamoto T, Horiuchi T, Akashi K, Niiro H.

    Medicine (Baltimore).   100 ( 13 )   e25406   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1097/MD.0000000000025406.

  • Human PD-1(hi)CD8(+) T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis Reviewed International journal

    Higashioka K, Yoshimura M, Sakuragi T, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Horiuchi T, Akashi K, Niiro H.

    FRONTIERS IN IMMUNOLOGY   12   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2021.654623

  • Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus Reviewed International journal

    Inokuchi S, Mitoma H, Kawano S, Ayano M, Kimoto Y, Akahoshi M, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

    Clin Exp Rheumatol.   2021.3

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  • Type 1 helper T cells generate CXCL9/10-producing T-bet(+) effector B cells potentially involved in the pathogenesis of rheumatoid arthritis Reviewed International journal

    Nakayama T, Yoshimura M, Higashioka K, Miyawaki K, Ota Y, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Akashi K, Horiuchi T, Niiro H.

    CELLULAR IMMUNOLOGY   360   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cellimm.2020.104263

  • Generation of a novel CD30+ B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis Reviewed

    K. Higashioka, Y. Kikushige, M. Ayano, Y. Kimoto, H. Mitoma, M. Kikukawa, M. Akahoshi, Y. Arinobu, T. Horiuchi, K. Akashi, H. Niiro

    Clinical and Experimental Immunology   201 ( 3 )   233 - 243   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cei.13477

  • Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents Reviewed

    Qiaolei Wang, Daisuke Oryoji, Hiroki Mitoma, Yasutaka Kimoto, Masamichi Koyanagi, Kana Yokoyama, Masahiro Ayano, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi

    Frontiers in Immunology   11   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2020.02042

  • Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease Reviewed

    Kazuhiko Higashioka, Yuri Ota, Takashi Maehara, Masafumi Moriyama, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Seiji Nakamura, Koichi Akashi, Hiroaki Niiro

    BMC Immunology   21 ( 1 )   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12865-020-00361-0

  • Homeostatic milieu induces production of deoxyribonuclease 1-like 3 from myeloid cells Reviewed

    Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Shota Nakano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Journal of Immunology   204 ( 8 )   2088 - 2097   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1901304

  • CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines Reviewed

    Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, Hisakata Yamada, Hirofumi Tsuzuki, Kensuke Irino, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Hiroshi Tsukamoto, Takahiko Horiuchi, Hiroaki Niiro, Koichi Akashi

    Arthritis Research and Therapy   21 ( 1 )   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-019-1984-x

  • A Japanese case of TNF receptor-associated periodic syndrome (TRAPS) successfully treated by canakinumab Reviewed International journal

    Motoki Yoshimura, Hiroki Mitoma, Yasutaka Kimoto, Daisuke Oryoji, Yukimi Otsuka, Qiaolei Wang, Shoichiro Inokuchi, Masahiro Ayano, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Koichi Kusuhara, Takahiko Horiuchi

    Modern Rheumatology Case Reports   2018.10

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    DOI: https://doi.org/10.1080/24725625.2018.1523830

  • Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study Reviewed

    Yukimi Otsuka, Chikako Kiyohara, Yusuke Kashiwado, Takuya Sawabe, Shuji Nagano, Yasutaka Kimoto, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi

    PloS one   13 ( 4 )   2018.4

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    DOI: 10.1371/journal.pone.0196368

  • Long-term efficacy of infliximab treatment and the predictors of treatment outcomes in patients with refractory uveitis associated with Behçet's disease Reviewed International journal

    5 ( 1 )   9 - 15   2018.3

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    DOI: doi: 10.5152/eurjrheum.2017.17068.

  • Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis Reviewed

    Atsushi Tanaka, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Naoyasu Ueda, Masahiro Ayano, Shun ichiro Ohta, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Yoshifumi Tada, Takahiko Horiuchi, Koichi Akashi

    Arthritis Research and Therapy   17 ( 1 )   2015.12

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    DOI: 10.1186/s13075-015-0547-z

  • The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factorα Reviewed

    19 ( 6 )   1224 - 1231   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MIB.0b013e318280b169

  • Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity Reviewed

    Atsushi Tanaka, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Naoyasu Ueda, Masahiro Ayano, Shun ichiro Ohta, Yasushi Inoue, Yojirou Arinobu, Hiroaki Niiro, Takahiko Horiuchi, Koichi Akashi

    Arthritis Research and Therapy   14 ( 6 )   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/ar4087

  • Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study. Reviewed International journal

    Hamaguchi Y, Kuwana M, Hoshino K, Hasegawa M, Kaji K, Matsushita T, Komura K, Nakamura M, Kodera M, Suga N, Higashi A, Ogusu K, Tsutsui K, Furusaki A, Tanabe H, Sasaoka S, Muro Y, Yoshikawa M, Ishiguro N, Ayano M, Muroi E, Fujikawa K, Umeda Y, Kawase M, Mabuchi E, Asano Y, Sodemoto K, Seishima M, Yamada H, Sato S, Takehara K, Fujimoto M.

    Arch Dermatol.   147 ( 4 )   391 - 398   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1001/archdermatol.2011.52.

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Presentations

  • 全身性エリテマトーデスにおける免疫抑制剤変更に関する検討:同系統継続 vs 他系統変更

    綾野 雅宏、木本 泰孝、三苫 弘喜、小野 伸之、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第66回日本リウマチ学会総会・学術集会  2022.4 

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    Event date: 2022.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • 全身性エリテマトーデスに対する初回寛解導入治療後の早期寛解達成に関連する因子の検討

    綾野 雅宏、木本 泰孝、三苫 弘喜、小野 伸之、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第65回日本リウマチ学会総会・学術集会  2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:オンライン   Country:Japan  

  • 全身性強皮症に対する自家造血幹細胞移植:CD34陽性細胞純化と非純化の比較検討

    綾野 雅宏、三苫 弘喜、塚本 浩、柏戸 佑介、木本 泰孝、赤星 光輝、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第63回日本リウマチ学会総会・学術集会  2019.4 

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    Event date: 2019.4

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 全身性エリテマトーデスに対するヒドロキシクロロキンのステロイド減量効果:タクロリムスとの比較検討

    綾野 雅宏、赤星 光輝、木本 泰孝、三苫 弘喜、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第63回日本リウマチ学会総会・学術集会  2019.4 

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    Event date: 2019.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都市   Country:Japan  

  • 全身性エリテマトーデス患者の長期予後に関する検討

    綾野 雅宏、木本 泰孝、三苫 弘喜、赤星 光輝、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第56回九州リウマチ学会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:佐賀市   Country:Japan  

  • 全身性強皮症に対する自家造血幹細胞移植の長期成績

    綾野 雅宏、三苫 弘喜、塚本 浩、柏戸 佑介、木本 泰孝、赤星 光輝、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第56回九州リウマチ学会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:佐賀市   Country:Japan  

  • ループス腎炎に対するタクロリムスの長期使用成績:10年間の検討

    綾野 雅宏、河野 正太郎、中野 未来、木本 泰孝、三苫 弘喜、赤星 光輝、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第62回日本リウマチ学会総会・学術集会  2018.4 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • ループス腎炎に対する免疫抑制剤併用療法:ミゾリビンvs ミコフェノール酸モフェチル

    綾野 雅宏、河野 正太郎、入野 健佑、中川 仁、木本 泰孝、三苫 弘喜、赤星 光輝、有信 洋二郎、赤司 浩一、堀内 孝彦、新納 宏昭

    第61回日本リウマチ学会総会・学術集会  2017.4 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 寛解導入後に残存した活動性皮疹に対してヒドロキシクロロキンが有効であった皮膚筋炎の2例

    綾野 雅宏, 久本 仁美, 押領司 大助, 大田 友里, 横山 佳奈, 木本 泰孝, 三苫 弘喜, 赤星 光輝, 有信 洋二郎, 赤司 浩一, 堀内 孝彦, 新納 宏昭

    第53回九州リウマチ学会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:別府   Country:Japan  

  • 重症全身性強皮症に対する自家造血幹細胞移植

    綾野 雅宏, 塚本 浩, 三苫 弘喜, 赤星 光輝, 有信 洋二郎, 赤司 浩一, 堀内 孝彦, 新納 宏昭

    第20回強皮症研究会議  2017.1 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 全身性エリテマトーデスの治療成績の推移:Treat-to-Target治療戦略の徹底および治療薬の充実による改善は得られたか?

    綾野 雅宏, 木本 泰孝, 三苫 弘喜, 小野 伸之, 有信 洋二郎, 堀内 孝彦, 新納 宏昭

    第68回日本リウマチ学会総会・学術集会  2024.4 

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    Language:Others  

    Country:Other  

  • 肩関節超音波検査を用いたリウマチ性多発筋痛症のステロイド反応性予測因子の検討

    綾野 雅宏, 有信 洋二郎, 久本 仁美, 中野 翔太, 中山 剛志, 髙木 綾子, 入野 健佑, 三苫 弘喜, 赤星 光輝, 新納 宏昭, 塚本 浩, 赤司 浩一

    第60回日本リウマチ学会総会・学術集会  2016.4 

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    Language:Japanese  

    Country:Japan  

  • 活動性残存全身性エリテマトーデスに対する追加治療:ヒドロキシクロロキン vs タクロリムス

    綾野 雅宏, 木本 泰孝, 三苫 弘喜, 小野 伸之, 有信 洋二郎, 赤司 浩一, 堀内 孝彦, 新納 宏昭

    第62回九州リウマチ学会  2021.9 

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    Country:Other  

  • 全身性エリテマトーデスに対する免疫抑制薬・生物学的製剤の選択状況:多施設データを用いた検討

    綾野 雅宏, 土井 吾郎, 大田 俊一郎, 久志本 和郎, 三嶋 耕司, 都留 智巳, 洲崎 みどり, 上田 尚靖, 中山 剛志, 田中 淳, 河野 正太郎, 西村 直矢, 多田 斉, 新納 宏昭

    第65回九州リウマチ学会  2023.3 

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    Country:Other  

  • 膠原病に伴う間質性肺疾患に対するニンテダニブの有用性の検討:開始量による比較

    綾野 雅宏, 福元 遼, 三苫 弘喜, 木本 泰孝, 小野 伸之, 有信 洋二郎, 堀内 孝彦, 新納 宏昭

    第67回日本リウマチ学会総会・学術集会  2023.4 

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    Language:Others  

    Country:Other  

  • 全身性エリテマトーデスにおける血清補体蛋白の経時的変化

    綾野 雅宏, 木本 泰孝, 三苫 弘喜, 小野 伸之, 有信 洋二郎, 堀内 孝彦, 新納 宏昭

    第59回日本補体学会学術集会  2023.8 

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    Country:Other  

  • 全身性エリテマトーデス診療における患者全般評価の臨床的意義:多施設データを用いた検討

    綾野 雅宏, 三嶋 耕司, 上田 尚靖, 田中 淳, 大田 俊一郎, 久志本 和郎, 都留 智巳, 洲崎 みどり, 西村 直矢, 河野 正太郎, 中山 剛志, 大本 史, 前川 真貴子, 柏戸 佑介, 赤星 光輝, 新納 宏昭

    第66回九州リウマチ学会  2023.9 

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    Language:Others  

    Country:Other  

  • 全身性エリテマトーデスに対するアニフロルマブの有用性:バイオナイーブ症例とスイッチ症例の比較検討

    綾野 雅宏, 上田 尚靖, 三嶋 耕司, 大田 俊一郎, 久志本 和郎, 田中 淳, 都留 智巳, 洲崎 みどり, 前川 真貴子, 木本 泰孝, 小野 伸之, 有信 洋二郎, 新納 宏昭

    第67回九州リウマチ学会  2024.3 

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    Country:Other  

  • ミクリッツ病疑いで加療中に発症した急性膵炎を契機に自己免疫性膵炎と診断し得たIgG4関連疾患の一例

    綾野 雅宏, 猪口 翔一朗, 中野 翔太, 久本 仁美, 木本 泰孝, 三苫 弘喜, 赤星 光輝, 有信 洋二郎, 赤司 浩一, 堀内 孝彦, 新納 宏昭

    第52回九州リウマチ学会  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

▼display all

MISC

  • Ⅲ. 血管炎症候群の症候と診断 2. 巨細胞性動脈炎

    綾野 雅宏, 新納 宏昭

    日本臨牀   2022.8

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    Language:Others  

  • 強皮症に対する自家造血幹細胞移植の有効性と安全性

    綾野 雅宏, 堀内 孝彦

    リウマチ科   2020.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 重症強皮症に対するmyeloablative autologous stem cell transplantation

    綾野 雅宏, 三苫 弘喜, 新納 宏昭

    2019.4

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  • 関節単純X線とエコーの読み方

    綾野 雅宏, 有信 洋二郎

    診断と治療   2016.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Toll-like receptor signalingとSLE

    綾野 雅宏, 堀内 孝彦

    リウマチ科   2010.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Professional Memberships

  • 日本補体学会

  • 日本臨床免疫学会

  • 日本リウマチ学会

  • 日本内科学会

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

Research Projects

  • 寛解期膠原病患者に残存する倦怠感の要因解明と治療戦略の確立

    Grant number:23K06868  2023 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • CD226を標的とした全身性エリテマトーデスに対する新規治療法の開発

    Grant number:19K17887  2019 - 2021

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アポトーシス/CD300aを基軸とした全身性強皮症の病態解明と新規治療法開発

    Grant number:16K19603  2016 - 2018

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

Other educational activity and Special note

  • 2016  Special Affairs 

Outline of Social Contribution and International Cooperation activities

  • 2022年11月第11回キャッスルマン病患者会医療講演会において講演を行った(演題名:iMCD/TAFRO症候群とCOVID-19)。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Collagen Disease, Allergy, Infectious Disease Internal Medicine

Clinician qualification

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Preceptor

    The Japanese Society of Internal Medicine(JSIM)

  • Specialist

    Japan College of Rheumatology(JCR)

  • Preceptor

    Japan College of Rheumatology(JCR)

  • 評議員

    Japan College of Rheumatology(JCR)

Year of medical license acquisition

  • 2005