2025/06/09 更新

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写真a

ツネヨシ シヨウジ
恒吉 章治
TSUNEYOSHI SHOJI
所属
九州大学病院 腎・高血圧・脳血管内科 助教
医学部 医学科(併任)
職名
助教
連絡先
メールアドレス
電話番号
0926425843
外部リンク

学位

  • 博士(医学)

研究テーマ・研究キーワード

  • 研究テーマ: 福岡腹膜透析データベース研究

    研究キーワード: 腹膜透析

    研究期間: 2024年4月

論文

  • Predictors of encapsulated peritoneal sclerosis in patients undergoing peritoneal dialysis using neutral-pH dialysate

    Nakano, T; Kitamura, H; Tsuneyoshi, S; Tsuchimoto, A; Torisu, K; Tsujikawa, H; Kawanishi, H; Tsuruya, K; Kitazono, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   2024年10月   ISSN:1342-1751 eISSN:1437-7799

     詳細を見る

    記述言語:英語   出版者・発行元:Clinical and Experimental Nephrology  

    Background: Encapsulated peritoneal sclerosis (EPS) is a serious complication in patients undergoing peritoneal dialysis (PD). Neutral-pH dialysate is associated with less peritoneal damage and a lower incidence of EPS than conventional PD solution. However, monitoring for peritoneal damage and predicting EPS remain important during PD therapy. Methods: We measured the mesothelial cell area, dialysate-to-plasma ratio of creatinine after 4 h, and concentrations of the potential biological markers effluent fibrin degradation products (eFDPs), cancer antigen-125, and interleukin-6 in the effluent dialysate from patients who had been undergoing PD therapy for > 5 years in our hospital. These biomarkers were obtained from the drainage fluid of the final measurement of peritoneal equilibration testing before withdrawal from PD therapy. The concentrations of these potential biomarkers were measured in 39 patients who withdrew from PD therapy and were enrolled in the study. Results: Three participants developed EPS after withdrawing PD. The dialysate-to-plasma ratio of creatinine, area of mesothelial cells, and interleukin-6 appearance rate in participants who developed EPS tended to be higher than those in patients who did not, but there were no significant differences. Significantly more eFDPs were in participants who developed EPS than in those who did not (138.5 ± 15.1 vs. 32.9 ± 7.4 µg/mL, P = 0.002). There was no difference in the cancer antigen-125 appearance rate between the groups. A cut-off value of eFDPs ≥ 119.1 µg/mL was optimal for predicting EPS (P = 0.006, specificity = 0.972, sensitivity = 1.000). Conclusion: This study shows that eFDPs may be a useful biological marker for predicting EPS in patients undergoing PD using neutral-pH dialysate.

    DOI: 10.1007/s10157-024-02565-9

    Web of Science

    Scopus

    PubMed

講演・口頭発表等

MISC

所属学協会

  • 日本内科学会

  • 日本腎臓学会

  • 日本透析医学会

教育活動概要

  • 医学部生の臨床実習(ベッドサイド実習、クリニカルクラークシップ)指導
    OSCE実習指導
    OSCE評価