Updated on 2024/11/28

Information

 

写真a

 
MATSUKUMA YUTA
 
Organization
Kyushu University Hospital Department of Nephrology,Hypertension,and Strokology Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Profile
腎疾患治療部において透析治療、腎疾患のコンサルテーションを、また、保存期CKD患者及び腹膜透析患者の外来診療をしている。 腎生検の組織診断に従事している。

Degree

  • Medical Doctor, Doctor of Philosophy

Research Interests・Research Keywords

  • Research theme:Renal pathology

    Keyword:Chronic kidney disease, arteriosclerosis, kidney transplantation

    Research period: 2021.5

Awards

  • 1. 2016 Asian Pacific Congress of Nephrology, Young Investigator Award Finalist 2. 2018年 第61回日本腎臓学会学術総会、優秀演題賞 3. 2018 ISN FRONTIERS, Top 10 rank poster

    2021.5  

Papers

  • Managing malignant hypertension with renal TMA: a case for caution in blood-pressure reduction

    Narumichi Iwamura, Yuta Matsukuma, Eisuke Katafuchi, Yoshiko Nakano, Kanako Tsutsumi, Yuki Ueno, Yasuhisa Tamura, Toshiaki Nakano

    CEN Case Reports   2024.11   ISSN:2192-4449 eISSN:2192-4449

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s13730-024-00933-8

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    Other Link: https://link.springer.com/article/10.1007/s13730-024-00933-8/fulltext.html

  • Persistent Chronic Active T-Cell-Mediated Rejection After Kidney Transplantation Is Associated With Poor Allograft Survival. International journal

    Hiroshi Noguchi, Yuta Matsukuma, Kenji Ueki, Akihiro Tsuchimoto, Kei Nishiyama, Toshiaki Nakano, Shinsuke Kubo, Yu Sato, Keizo Kaku, Yasuhiro Okabe, Masafumi Nakamura

    Clinical transplantation   38 ( 11 )   e70011   2024.11   ISSN:09020063

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    INTRODUCTION: Histopathological findings of chronic active T-cell-mediated rejection (CA-TCMR) have been reported to potentially improve with treatment. However, whether this improvement is associated with a better renal prognosis remains unclear. This study was performed to analyze the impact of the histological response to therapy on kidney allograft survival in patients with CA-TCMR. METHODS: The data of patients diagnosed with CA-TCMR between January 2018 and May 2023 were retrospectively reviewed. A composite graft endpoint was defined as a two-fold increase in the serum creatinine level or the development of end-stage kidney disease. RESULTS: Thirty-seven patients with CA-TCMR underwent 46 follow-up biopsies. Eleven patients who were diagnosed with CA-TCMR at the last biopsy were classified as the persistent group, while the remaining 26 patients were classified as the transient group. Both before and after treatment, there were no significant changes in serum creatinine, estimated glomerular filtration rate, or proteinuria in either group. However, the transient group showed a significant reduction in interstitial fibrosis and tubular atrophy without a specific etiology (IFTA). This improvement was attributed to better histopathological Banff scores after treatment. Patients with persistent CA-TCMR had significantly worse graft survival than those with transient CA-TCMR (p = 0.002), even after adjusting for significant clinical factors (hazard ratio: 11.4; 95% CI: 1.1-120.0; p = 0.043). CONCLUSION: Our findings suggest that the persistence of histopathologic evidence of CA-TCMR after treatment is a significant risk factor for allograft loss compared with transient CA-TCMR.

    DOI: 10.1111/ctr.70011

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  • Association between Hemoglobin A1c and Renal Arteriolar Sclerosis in Subjects Presenting without any Apparent Kidney Dysfunction

    Matsukuma Yuta, Tsuchimoto Akihiro, Masutani Kosuke, Ueki Kenji, Tanaka Shigeru, Haruyama Naoki, Okabe Yasuhiro, Nakamura Masafumi, Kitazono Takanari, Nakano Toshiaki

    Journal of Atherosclerosis and Thrombosis   31 ( 8 )   1215 - 1224   2024.8   ISSN:13403478 eISSN:18803873

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Atherosclerosis Society  

    <p> <b>Aims:</b> Diabetic kidney disease is a major vascular complication in patients with diabetes mellitus (DM). However, the association between the hemoglobin (Hb)A1c levels, notably the prediabetic levels, and renal pathological changes remains unclear. We investigated the association between the HbA1c levels and renal arteriolar lesions in subjects without any apparent kidney dysfunction using a living kidney donor cohort.</p><p><b>Methods:</b> Between January 2006 and May 2016, 393 living kidney donors underwent a “zero-time” biopsy at Kyushu University Hospital. The patients were divided into four groups (HbA1c levels <5.6%, 5.6%–5.7%, 5.8%–6.4%, and ≥ 6.5%, or diagnosed with DM [DM group]). Renal arteriolar hyalinization and wall thickening were assessed using semi-quantitative grading. We then investigated the association between the HbA1c levels and renal pathological changes.</p><p><b>Results:</b> 158 (40.2%) patients had arteriolar hyalinization and 148 (37.6%) showed wall thickening. A significant correlation was observed between the HbA1c levels and wall thickening (<i>p</i> for trend <0.001). An elevated HbA1c level was significantly associated with wall thickening according to a multivariable logistic analysis in subjects with HbA1c levels of 5.6%–5.7% and 5.8%–6.4%, and the DM group, compared with those with HbA1c levels of <5.6% (odds ratio [OR], 1.91; 95% confidence interval [CI]: [1.03–3.54] for 5.6%–5.7%, OR, 1.96; 95% CI: [1.09–3.53] for 5.8%–6.4%, and OR, 2.86; 95% CI: [0.91–9.01] for the DM group), whereas arteriolar hyalinization did not increase within the nondiabetic HbA1c levels.</p><p><b>Conclusions:</b> Elevated high-normal HbA1c levels are considered to be independent risk factors for arteriolar wall thickening. Subclinical renal arteriolar sclerosis may develop in patients with prediabetic HbA1c levels.</p>

    DOI: 10.5551/jat.64236

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  • Association between Hemoglobin A1c and Renal Arteriolar Sclerosis in Subjects Presenting without any Apparent Kidney Dysfunction(タイトル和訳中)

    Matsukuma Yuta, Tsuchimoto Akihiro, Masutani Kosuke, Ueki Kenji, Tanaka Shigeru, Haruyama Naoki, Okabe Yasuhiro, Nakamura Masafumi, Kitazono Takanari, Nakano Toshiaki

    Journal of Atherosclerosis and Thrombosis   31 ( 8 )   1215 - 1224   2024.8   ISSN:1340-3478

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  • Combined evaluation of glomerular phospholipase A2 receptor and immunoglobulin G subclass in membranous nephropathy. International journal

    Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Eri Ataka, Hirofumi Okamoto, Shigeru Tanaka, Kosuke Masutani, Takanari Kitazono, Toshiaki Nakano

    Clinical kidney journal   17 ( 6 )   sfae104   2024.6   ISSN:2048-8505 eISSN:2048-8513

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    BACKGROUND: Phospholipase A2 receptor (PLA2R) is a major target antigen in idiopathic membranous nephropathy (MN). Anti-PLA2R antibodies are mainly of the immunoglobulin G (IgG) subclass IgG4, although other IgG subclass depositions in glomeruli may also be detected. However, the importance of the subclass of the IgG deposit has not been proven. Thus we investigated clinical findings from patients with idiopathic MN in relation to glomerular PLA2R deposition and IgG subclass. METHODS: We enrolled 132 Japanese patients with biopsy-proven idiopathic MN in a multicentre retrospective observational study. We investigated the complete remission rate as the primary outcome and the development of end-stage kidney disease (ESKD) as the secondary outcome in relation to glomerular PLA2R deposition. Moreover, we evaluated prognostic factors, including glomerular IgG subclass, in the PLA2R-positive group. RESULTS: The percentage of cases with glomerular PLA2R deposition was 76.5% (n = 101). The first complete remission rate of the PLA2R-positive group was worse than that of the PLA2R-negative group (logrank test P < .001). ESKD incidence did not significantly differ between the glomerular PLA2R-negative and PLA2R-positive MN groups (logrank test P = .608). In the PLA2R-positive group, higher PLA2R intensities and IgG2 staining were associated with a poorer first complete remission rate (logrank test P < .001 and P = .032, respectively). Cox proportional hazards analysis also showed that strong PLA2R deposition and positive IgG2 staining were significantly associated with a failure to reach complete remission [hazard ratio 2.09 (P = .004) and 1.78 (P = .030), respectively]. CONCLUSIONS: Our results suggest that intense glomerular PLA2R and IgG2 positivity predict a poor proteinuria remission rate in idiopathic MN.

    DOI: 10.1093/ckj/sfae104

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  • A case of end-stage kidney disease due to Alport syndrome diagnosed by skin biopsy after review of a renal biopsy 12 years ago.

    Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Takanari Kitazono, Toshiaki Nakano

    CEN case reports   2024.5   ISSN:2192-4449

  • Significance of Perivascular Aggregates in Kidney Allografts: Evaluation of 1-Year Protocol Biopsies Using Recent Banff Classification. International journal

    Kosuke Masutani, Kaneyasu Nakagawa, Yuta Matsukuma, Kenji Ueki, Eri Ataka, Akihiro Tsuchimoto, Yasuhiro Okabe, Masafumi Nakamura, Takanari Kitazono, Toshiaki Nakano

    Transplantation proceedings   56 ( 3 )   499 - 504   2024.4   ISSN:0041-1345 eISSN:1873-2623

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    BACKGROUND: Perivascular aggregates (PVAs) often occur in kidney allografts; however, their significance needs to be re-evaluated in light of changes in the concept and criteria of allograft rejection. METHODS: We reviewed 1-year protocol biopsies in 258 patients with kidney transplants to identify PVAs and concurrent pathology based on the Banff 2017 classification, including revised criteria for chronic active T-cell mediated rejection (CA-TCMR). We investigated the incidence of PVA, concurrent allograft lesions, diagnosis, and graft survival. No prisoners were used in this study, and no participants were coerced or paid. RESULTS: We identified PVA in 81 biopsies (31.4%). The incidence of previous rejection (32.1% vs 12.4%, P= .0003) and total inflammation (1.3 ± 0.8 vs 0.6 ± 0.8, P < .0001), inflammation (0.7 ± 0.8 vs 0.2 ± 0.5, P < .0001), inflammation in the area of interstitial fibrosis and tubular atrophy (1.3 ± 1.2 vs 0.7 ± 0.9, P < .0001), tubulitis (1.4 ± 1.1 vs 0.6 ± 0.9, P < .0001), and interstitial fibrosis scores (1.2 ± 0.9 vs 0.9 ± 0.9, P= .01) were higher in PVA-positive compared with patients with PVA-negative. Diagnoses in the PVA-positive group revealed no rejection in 49.4%, CA-TCMR in 21.0%, borderline changes in 18.5%, and acute TCMR in 6.2%. CA-TCMR was more frequent in patients with PVA-positive (21.0% vs 4.0%, P < .0001). Graft survival was similar in both groups among all patients, no-rejection, any type of rejection, and CA-TCMR subgroups. CONCLUSIONS: PVAs occur heterogeneously and are associated with previous rejection or concurrent CA-TCMR. The prognostic significance of PVAs in kidney transplantation is inconclusive, and further investigations are needed.

    DOI: 10.1016/j.transproceed.2024.01.012

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  • Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease

    Koga, R; Maehara, T; Aoyagi, R; Munemura, R; Murakami, Y; Doi, A; Kono, M; Yamamoto, H; Niiro, H; Kiyoshima, T; Tanabe, M; Nakano, T; Matsukuma, Y; Kawano, M; Stone, JH; Pillai, S; Nakamura, S; Kawano, S

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   153 ( 4 )   1095 - 1112   2024.4   ISSN:0091-6749 eISSN:1097-6825

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    Background: IgG4-related disease (IgG4-RD), an example of a type I immune disease, is an immune-mediated fibrotic disorder characterized by dysregulated resolution of severe inflammation and wound healing. However, truly dominant or pathognomonic autoantibodies related to IgG4-RD are not identified. Objective: We sought to perform single-cell RNA sequencing and T-cell receptor and B-cell receptor sequencing to obtain a comprehensive, unbiased view of tissue-infiltrating T and B cells. Methods: We performed unbiased single-cell RNA-sequencing analysis for the transcriptome and T-cell receptor sequencing and B-cell receptor sequencing on sorted CD3+ T or CD19+ B cells from affected tissues of patients with IgG4-RD. We also conducted quantitative analyses of CD3+ T-cell and CD19+ B-cell subsets in 68 patients with IgG4-RD and 30 patients with Sjögren syndrome. Results: Almost all clonally expanded T cells in these lesions were either Granzyme K (GZMK)-expressing CD4+ cytotoxic T cells or GZMK+CD8+ T cells. These GZMK-expressing cytotoxic T cells also expressed amphiregulin and TGF-β but did not express immune checkpoints, and the tissue-infiltrating CD8+ T cells were phenotypically heterogeneous. MKI67+ B cells and IgD−CD27−CD11c−CXCR5− double-negative 3 B cells were clonally expanded and infiltrated affected tissue lesions. GZMK+CD4+ cytotoxic T cells colocalized with MKI67+ B cells in the extrafollicular area from affected tissue sites. Conclusions: The above-mentioned cells likely participate in T-B collaborative events, suggesting possible avenues for targeted therapies. Our findings were validated using orthogonal approaches, including multicolor immunofluorescence and the use of comparator disease groups, to support the central role of cytotoxic CD4+ and CD8+ T cells expressing GZMK, amphiregulin, and TGF-β in the pathogenesis of inflammatory fibrotic disorders.

    DOI: 10.1016/j.jaci.2023.11.916

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  • A Single-Center Retrospective Study of Re-Transplantation After Allograft Failure in Kidney Transplant Recipients. International journal

    Hiroshi Noguchi, Kyoko Miyamoto, Yuta Matsukuma, Kenji Ueki, Akihiro Tsuchimoto, Toshiaki Nakano, Akari Kaba, Yu Sato, Shinsuke Kubo, Keizo Kaku, Yasuhiro Okabe, Masafumi Nakamura

    Transplantation proceedings   56 ( 3 )   488 - 493   2024.4   ISSN:0041-1345 eISSN:1873-2623

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    BACKGROUND: This study aimed to examine the outcomes of kidney retransplantation in patients with allograft failure at Kyushu University. METHODS: We reviewed data from 1043 consecutive patients (including 1001 in a first kidney transplantation [KT] group and 42 in a second KT group) who had undergone KT alone at our institution between January 2008 and September 2022. We also studied immunologic risks and outcomes of patients who had undergone preoperative testing for KT at Kyushu University during the same period. RESULTS: No patient received more than 2 transplants. Donor-specific anti-HLA antibody (DSA) had been detected in a greater percentage of patients in the second KT group than in the first (31% vs 11%, respectively; P < .001). There were no significant differences in 5-year death-censored/overall graft survival rates, rates of surgical complications, or incidence of delayed graft function between the groups. During the study period, significantly more candidates for second than first KT were rejected for this procedure because of their high immunologic risk (20% vs 2%, P < 001). Seven of the 42 patients in the second KT group required the removal of the primary graft during the second transplantation. CONCLUSION: There is a higher percentage of patients whose DSA has been detected among patients undergoing retransplantation after allograft failure than among those receiving first KTs, which often leads to remaining on the waiting list in the former group. However, if the immunologic risk is within acceptable limits, the graft survival for retransplantation is not inferior to that of a first KT.

    DOI: 10.1016/j.transproceed.2024.01.053

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  • Cumulative smoking dose is associated with subclinical renal injury: a pathological study in individuals without chronic kidney disease

    Eri Ataka, Yuta Matsukuma, Kenji Ueki, Akihiro Tsuchimoto, Yasuhiro Okabe, Kosuke Masutani, Masafumi Nakamura, Toshiaki Nakano, Takanari Kitazono

    Nephrology Dialysis Transplantation   38 ( 12 )   2799 - 2808   2023.11   ISSN:0931-0509 eISSN:1460-2385

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    ABSTRACT

    Background

    Epidemiological studies have identified smoking as an independent risk factor for development of chronic kidney disease. However, the early renal pathological lesions have not been clearly elucidated.

    Methods

    We investigated time-zero biopsy specimens from 547 living kidney donors and evaluated the relationships between smoking and renal histological changes, including arteriolar hyalinization, intimal thickening of small–medium arteries, global glomerulosclerosis, and interstitial fibrosis and tubular atrophy (IF/TA).

    Results

    A total of 199 subjects (36.4%) had smoking history; 92 (16.8%) and 107 (19.6%) subjects had &amp;lt;20 pack-years and ≥20 pack-years of smoking, respectively. Cumulative smoking dose was significantly associated with prevalence of arteriolar hyalinization: the multivariable-adjusted odds ratio (OR) per 20 pack-year increase was 1.50 (95% confidence interval 1.15–1.97). The ORs for smokers with &amp;lt;20 pack-years and ≥20 pack-years versus never-smokers were 1.76 (1.01–3.09) and 2.56 (1.48–4.44), respectively. Smoking was also associated with prevalence of &amp;gt;10% global glomerulosclerosis: the OR per 20 pack-year increase was 1.24 (0.96–1.59). The ORs for smokers with &amp;lt;20 pack-years and ≥20 pack-years versus never-smokers were 1.50 (0.98–2.78) and 2.11 (1.18–3.79), respectively. The ORs for these pathological changes increased significantly depending on cumulative smoking dose. Intimal thickening of small–medium arteries and IF/TA were not associated with smoking status. The prevalence of arteriolar hyalinization remained higher in patients with ≥10 years since smoking cessation than in never-smokers [OR 2.23 (1.03–4.83)].

    Conclusions

    Subclinical pathological injury caused by smoking is potentially associated with renal arteriolar hyalinization and glomerular ischaemia.

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  • Design and methods of an open-label, randomized controlled trial to evaluate the effect of pemafibrate on proteinuria in CKD patients (PROFIT-CKD).

    Mai Seki, Toshiaki Nakano, Shigeru Tanaka, Yuta Matsukuma, Kouta Funakoshi, Toshiaki Ohkuma, Takanari Kitazono

    Clinical and experimental nephrology   27 ( 4 )   358 - 364   2023.4   ISSN:1342-1751 eISSN:1437-7799

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    BACKGROUND: Hypertriglyceridemia is increasingly considered a residual risk of cardiovascular disease in patients with chronic kidney disease (CKD). Pemafibrate-a novel selective peroxisome proliferator-activated receptor alpha modulator and a new treatment for hypertriglyceridemia in CKD patients-is reported to have fewer side effects in CKD patients than other fibrates. Appropriate control of hypertriglyceridemia can be expected to improve renal prognosis. However, data on the renal protective effect of pemafibrate are limited. This study aims to evaluate the effectiveness of pemafibrate on urinary protein excretion in CKD patients. METHODS: The Pemafibrate, open-label, Randomized cOntrolled study to evaluate the renal protective eFfect In hyperTriglyceridemia patients with Chronic Kidney Disease (PROFIT-CKD) study is an investigator-initiated, multi-center, open-label, parallel-group, randomized controlled trial. Participants are outpatients with hypertriglyceridemia aged 20 years and over, who have received the care of a nephrologist or a diabetologist for more than 3 months. Inclusion criteria include the following: proteinuria (urine protein/creatinine ratio of ≥ 0.15 g/gCr) within three months before allocation, and hypertriglyceridemia (triglycerides ≥ 150 mg/dL and < 1,000 mg/dL) at allocation. In the treatment group, pemafibrate is added to conventional treatment, while conventional treatment is continued with no additional treatment in the control group. Target patient enrollment is 140 patients. The primary endpoint is the change from baseline in the logarithmic urine protein/creatinine ratio at 12 months after study start. CONCLUSION: This study will provide new findings on the renal protective effect of pemafibrate in CKD patients. CLINICAL TRIAL REGISTRATION: This clinical trial was registered at the University Hospital Medical Information Network (UMIN) Center (UMIN-CTR: UMIN000042284).

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  • CKD患者の蛋白尿に対するペマフィブラートの効果を評価する非盲検ランダム化比較試験(PROFIT-CKD)のデザインと方法(Design and methods of an open-label, randomized controlled trial to evaluate the effect of pemafibrate on proteinuria in CKD patients(PROFIT-CKD))

    Seki Mai, Nakano Toshiaki, Tanaka Shigeru, Matsukuma Yuta, Funakoshi Kouta, Ohkuma Toshiaki, Kitazono Takanari

    Clinical and Experimental Nephrology   27 ( 4 )   358 - 364   2023.4   ISSN:1342-1751

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  • 慢性活動性T細胞性拒絶反応(CA-TCMR)への治療が移植腎予後へ与える影響

    野口 浩司, 松隈 祐太, 植木 研次, 土本 晃裕, 加来 啓三, 岡部 安博, 中村 雅史

    移植   58 ( Supplement )   s331_1 - s331_1   2023   ISSN:05787947 eISSN:21880034

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    Language:Japanese   Publisher:一般社団法人 日本移植学会  

    <p>【背景】腎移植後の慢性活動性T細胞性拒絶反応(CA-TCMR)は腎予後が不良だと考えられている。一方で治療によりその病理所見が改善する可能性についてはすでに報告した。しかし、病理所見の改善が腎予後の改善につながるかは不明であった。【対象・方法】2018年から2022年2月までに生検でCA-TCMRと診断され、治療後確認生検をおこなった32例を検討した。【結果】32例のうち病理所見上、B/CまたはNormalまで改善したものをResponder群(n=20)、そうでないものをNon-responder群(n=12)とした。Responder群ではti, i-IFTA, t-IFTAのスコアは治療前と比べ有意に改善していたのに対しNon-responder群では改善は見られなかった。血清クレアチニンの倍加、末期腎不全を複合アウトカムとした場合、Non-responder群に観察期間中に3例認めたのに対して、Responder群では認めず二群間の累積発症率に有意差を認めた(P=0.019)。またeGFRの低下率もNon-responder群では-6.5%/年に対して、Responder群では-0.2%/年と有意差を認めた(P<0.001)。一方で治療の前後では二群間で腎機能(eGFR)に変化を認めなかった。【結語】腎移植後CA-TCMRを発症しても治療を行い病理学的にB/CまたはNormalまで改善したものは、腎予後も良好であることが示唆された。一方で病理学的所見上の改善と治療前後の臨床所見は相関せず、確認生検が必要であると思われた。</p>

    DOI: 10.11386/jst.58.supplement_s331_1

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  • Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

    Yamamoto R., Imai E., Maruyama S., Yokoyama H., Sugiyama H., Takeda A., Uchida S., Tsukamoto T., Tsuruya K., Akai Y., Nitta K., Fukunaga M., Hayashi H., Masutani K., Wada T., Konta T., Katafuchi R., Nishio S., Goto S., Tamai H., Shirasaki A., Shoji T., Nagai K., Nishino T., Yamagata K., Kazama J.J., Hiromura K., Yasuda H., Mizutani M., Naruse T., Hiramatsu T., Morozumi K., Sobajima H., Saka Y., Ishimura E., Ichikawa D., Shigematsu T., Sofue T., Fujimoto S., Ito T., Sato H., Narita I., Isaka Y., Nishio S., Ishikawa Y., Nakazawa D., Nakagaki T., Sato T., Sato M., Sanada S., Sato H., Miyazaki M., Nakamichi T., Yamamoto T., Narumi K., Yamada G., Ichikawa K., Watanabe T., Asahi K., Kusano Y., Watanabe K., Usui J., Kaneko S., Kawamura T., Maeshima A., Kaneko Y., Ikeuchi H., Sakairi T., Nakasatomi M., Hasegawa H., Iwashita T., Shimizu T., Kanozawa K., Ogawa T., Takayanagi K., Mitarai T., Okada H., Inoue T., Suzuki H., Tomori K., Moriyama T., Ino A., Sato M., Nakajima H., Homma H., Nagura N., Tamura Y., Shibata S., Fujigaki Y., Suzuki Y., Takeda Y., Osawa I., Hidaka T.

    Scientific Reports   12 ( 1 )   2022.12

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    Previous studies reported conflicting results regarding an association between serum albumin concentration and the cumulative incidence of remission of proteinuria in adult patients with minimal change disease (MCD). The present study aimed to clarify the clinical impact of serum albumin concentration and the cumulative incidence of remission and relapse of proteinuria in 108 adult patients with MCD at 40 hospitals in Japan, who were enrolled in a 5-year prospective cohort study of primary nephrotic syndrome, the Japan Nephrotic Syndrome Cohort Study (JNSCS). The association between serum albumin concentration before initiation of immunosuppressive treatment (IST) and the cumulative incidence of remission and relapse were assessed using multivariable-adjusted Cox proportional hazards models. Remission defined as urinary protein < 0.3 g/day (or g/gCr) was observed in 104 (96.3%) patients. Of 97 patients with remission within 6 month of IST, 42 (43.3%) developed relapse defined as ≥ 1.0 g/day (or g/gCr) or dipstick urinary protein of ≥ 2+. Serum albumin concentration was significantly associated with remission (multivariable-adjusted hazard ratio [95% confidence interval] per 1.0 g/dL, 0.57 [0.37, 0.87]), along with eGFR (per 30 mL/min/1.73 m2: 1.43 [1.08, 1.90]), whereas they were not associated with relapse. A multivariable-adjusted model showed that patients with high eGFR level (≥ 60 mL/min/1.73 m2) and low albumin concentration (≤ 1.5 g/dL) achieved significantly early remission, whereas those with low eGFR (< 60 mL/min/1.73 m2) and high albumin concentration (> 1.5 g/dL) showed significantly slow remission. In conclusion, lower serum albumin concentration and higher eGFR were associated with earlier remission in MCD, but not with relapse.

    DOI: 10.1038/s41598-022-13067-7

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  • Cumulative Smoking Dose Is a Risk Factor for Renal Arteriolar Hyalinization and Glomerular Sclerosis in Individuals Without CKD: A Cross-Sectional Study

    Ataka, E; Matsukuma, Y; Ueki, K; Tsuchimoto, A; Okabe, Y; Masutani, K; Nakano, T; Kitazono, T

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   33 ( 11 )   210 - 211   2022.11   ISSN:1046-6673 eISSN:1533-3450

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  • Treatment of chronic active T cell-mediated rejection after kidney transplantation: A retrospective cohort study of 37 transplants

    Noguchi, H; Matsukuma, Y; Nakagawa, K; Ueki, K; Tsuchimoto, A; Nakano, T; Sato, Y; Kaku, K; Okabe, Y; Nakamura, M

    NEPHROLOGY   27 ( 7 )   632 - 638   2022.7   ISSN:1320-5358 eISSN:1440-1797

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    Aim: Data on the treatment of chronic active T cell-mediated rejection (CA-TCMR) are scarce, and therapeutical strategies for CA-TCMR have not been established. We retrospectively evaluated the outcomes and effects of treatment on pathological and clinical findings in patients with CA-TCMR. Methods: This study comprised 37 patients who underwent kidney transplantation at our institute who were diagnosed with CA-TCMR between January 2018 and December 2020. Patients were followed until October 2021. Results: A total of 32 of the 37 patients were treated. During the observation period, two patients died (5%), and five patients developed allograft loss (13%). A univariate Cox proportional hazards model showed that indication biopsy, higher spot urine protein/creatinine ratio (UPCR) and Banff ci/ct scores were risk factors for allograft loss. Of the treated patients, 23 underwent follow-up biopsies. The Wilcoxon signed-rank test showed significant improvement in the Baff scores for “ti”, “i-IFTA”, “t” and “t-IFTA” after treatment. On pathology, 13 (57%) of the patients who underwent follow-up biopsy improved to “no evidence of rejection” or “borderline change.” Assuming that improvement in pathology to “borderline change” or “no evidence of rejection” on follow-up biopsy indicates response to treatment, multivariate logistic analysis showed that lower UPCR was a predictive factor for response to treatment. No specific effect of treatment type was observed. Conclusions: Our results indicate that treatment could improve the pathological findings in CA-TCMR.

    DOI: 10.1111/nep.14048

    Web of Science

    Scopus

    PubMed

  • Design of porous metal collector via bubble template-assisted electrochemical deposition using numerical simulation

    Inoue, G; Abe, S; Gao, RJ; Park, K; So, M; Matsukuma, Y; Kimura, N; Tsuge, Y

    CHEMICAL ENGINEERING JOURNAL ADVANCES   10   2022.5   ISSN:2666-8211

  • Time to remission of proteinuria and incidence of relapse in patients with steroid-sensitive minimal change disease and focal segmental glomerulosclerosis: the Japan Nephrotic Syndrome Cohort Study

    Yamamoto R., Imai E., Maruyama S., Yokoyama H., Sugiyama H., Takeda A., Tsukamoto T., Uchida S., Tsuruya K., Shoji T., Hayashi H., Akai Y., Fukunaga M., Konta T., Nishio S., Goto S., Tamai H., Nagai K., Katafuchi R., Masutani K., Wada T., Nishino T., Shirasaki A., Sobajima H., Nitta K., Yamagata K., Kazama J.J., Hiromura K., Yasuda H., Mizutani M., Akahori T., Naruse T., Hiramatsu T., Morozumi K., Mimura T., Saka Y., Ishimura E., Hasegawa H., Ichikawa D., Shigematsu T., Sato H., Narita I., Isaka Y., Komatsu H., Iwakiri T., Nishizono R., Kikuchi M., Sato Y., Fujimoto S., Obata Y., Uramatsu T., Abe K., Matsueda S., Nagae H., Nakamura N., Kurokawa Y., Yoshida C., Yano J., Fukami K., Ito K., Yasuno T., Hamauchi A., Abe Y., Matsukuma Y., Tsuchimoto A., Yamada S., Haruyama N., Yoshida H., Matsumoto T., Shimamura Y., Inoue K., Taniguchi Y., Horino T., Terada Y., Minamino T., Kushida Y., Nishijima Y., Hara T., Moriwaki K., Kiyomoto H., Sofue T., Doi T., Nagasu H., Fujimoto S., Sasaki T., Kashihara N., Mise K., Onishi A., Kitagawa M., Yamanari T., Tanaka K., Ito T., Mima T., Negi S., Ohya M., Tsushima H., Tanabe K., Tagawa M., Matsui M., Samejima K.I.

    Journal of Nephrology   35 ( 4 )   1135 - 1144   2022.5   ISSN:11218428

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    Publisher:Journal of Nephrology  

    Background: Minimal change disease (MCD) is characterized by a nephrotic syndrome usually steroid-sensitive and a high incidence of relapse of proteinuria. Previous cohort studies have reported conflicting results regarding the association between the time to remission and incidence of relapse. Methods: This multicenter prospective cohort study included 102 adult patients with steroid-sensitive MCD or focal segmental glomerulosclerosis from a 5-year cohort study of primary nephrotic syndrome, the Japan Nephrotic Syndrome Cohort Study, who achieved remission of proteinuria within 2 months of immunosuppressive therapy (IST). The association between the time to remission of proteinuria after immunosuppressive therapy and incidence of relapse was assessed using Cox proportional hazards models adjusted for clinically relevant factors. Results: Remission was observed at 3–7, 8–14, 15–21, 22–28, and 30–56 days after initiation of immunosuppressive therapy in 17 (16.7%), 37 (36.3%), 21 (20.6%), 13 (12.7%), and 14 (13.7%) patients, respectively. During a median observation period of 2.3 years after the end of the 2nd month after initiation of immunosuppressive therapy, 46 (45.1%) patients relapsed. The time to remission was associated with the incidence of relapse in an inverse U-shaped pattern (multivariable-adjusted hazard ratios [95% confidence intervals] of the time to remission of 3–7, 8–14, 15–21, 22–28, 30–56 days: 1.00 [reference], 1.76 [0.56, 5.51], 6.06 [1.85, 19.80], 5.46 [1.44, 20.64], and 2.19 [0.52, 9.30], respectively). Conclusion: The time to remission was identified as a significant predictor of relapse in steroid-sensitive patients.

    DOI: 10.1007/s40620-022-01279-z

    Scopus

  • 生体腎移植後の早期ARB内服開始に関する安全性・有効性の検討

    久保 進祐, 野口 浩司, 佐藤 優, 目井 孝典, 植木 研次, 松隈 祐太, 加来 啓三, 岡部 安博, 中村 雅史

    移植   57 ( Supplement )   s378_1 - s378_1   2022   ISSN:05787947 eISSN:21880034

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    Language:Japanese   Publisher:一般社団法人 日本移植学会  

    <p><背景>腎移植後早期の血圧管理には主にカルシウム拮抗薬が用いられ、早期からアンジオテンシンⅡ受容体拮抗薬(ARB)を使用することに関しての安全性や有効性は定かではない。<方法>2020年5月〜2022年3月に当科で行われた生体腎移植で、タクロリムス、ミコフェノール酸モフェチル、ステロイドの3剤で免疫抑制導入され、免疫学的低リスクの成人症例で、移植後3ヶ月に腎生検を実施した計78例について検討した。術後早期よりARBを開始した症例をARB群(27例)、それ以外をControl群(51例)とし、さらに逆確率重み付け(IPW)を用いて患者背景を2群間で調整し、3ヶ月後の腎機能および生検結果について比較した。<結果>術後3ヶ月時点での血清クレアチニン、推算糸球体濾過量、高K血症や血圧低下などの有害事象の出現頻度については二群間に有意差は認めなかった。尿蛋白/尿クレアチニン比(Up/Uc)はARB群でContorolに比べ低い傾向にあった(0.12 vs. 0.16 , <i>p</i>=0.176)。また術後3ヶ月目に行った腎生検結果では、ARB群ではIF/TAの出現率は低い傾向にあった(9.3% vs 17.6%, p=0.313)。<結論>低用量からARBを術後早期に始めることは安全であった。</p>

    DOI: 10.11386/jst.57.supplement_s378_1

    CiNii Research

  • Association between the urinary sodium-to-potassium ratio and renal outcomes in patients with chronic kidney disease: a prospective cohort study. International journal

    Yuta Matsukuma, Masaru Nakayama, Susumu Tsuda, Akiko Fukui, Ryota Yoshitomi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 11 )   1492 - 1504   2021.11

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    DOI: 10.1038/s41440-021-00741-y

  • Association between the urinary sodium-to-potassium ratio and renal outcomes in patients with chronic kidney disease: a prospective cohort study. Invited Reviewed International journal

    Matsukuma Y, Nakayama M, Tsuda S, Fukui A, Yoshitomi R, Tsuruya K, Nakano T, Kitazono T.

    Hypertens Res   2021.11

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  • Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study.

    Masatoshi Hara, Shigeru Tanaka, Kumiko Torisu, Yuta Matsukuma, Akihiro Tsuchimoto, Masanori Tokumoto, Hiroaki Ooboshi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Clinical and experimental nephrology   25 ( 8 )   822 - 834   2021.8

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    DOI: 10.1007/s10157-020-02018-z

  • Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study. Invited Reviewed International journal

    Hara M, Tanaka S, Torisu K, Matsukuma Y, Tsuchimoto A, Tokumoto M, Ooboshi H, Nakano T, Tsuruya K, Kitazono T.

    Clin Exp Nephrol.   25 ( 8 )   822 - 834   2021.8

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  • Subclinical hypothyroidism is independently associated with poor renal outcomes in patients with chronic kidney disease. Invited Reviewed International journal

    Tsuda S, Nakayama M, Matsukuma Y, Yoshitomi R, Haruyama N, Fukui A, Nakano T, Tsuruya K, Kitazono T.

    Endocrine.   73 ( 1 )   141 - 150   2021.7

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  • Subclinical hypothyroidism is independently associated with poor renal outcomes in patients with chronic kidney disease. International journal

    Susumu Tsuda, Masaru Nakayama, Yuta Matsukuma, Ryota Yoshitomi, Naoki Haruyama, Akiko Fukui, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Endocrine   73 ( 1 )   141 - 150   2021.7

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    DOI: 10.1007/s12020-021-02611-6

  • High low-density lipoprotein cholesterol as an independent risk factor for coronary restenosis in hemodialysis patients undergoing percutaneous coronary interventions. International journal

    Shoko Hasegawa, Toshiaki Nakano, Yasushi Mukai, Yuta Matsukuma, Ryusuke Yotsueda, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kazuhiko Tsuruya, Hiroyuki Tsutsui, Takanari Kitazono

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   25 ( 3 )   296 - 303   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1744-9987.13558

  • High low-density lipoprotein cholesterol as an independent risk factor for coronary restenosis in hemodialysis patients undergoing percutaneous coronary interventions. Invited Reviewed International journal

    Hasegawa S, Nakano T, Mukai Y, Matsukuma Y, Yotsueda R, Tsuchimoto A, Fujisaki K, Tsuruya K, Tsutsui H, Kitazono T.

    Ther Apher Dial.   25 ( 3 )   296 - 303   2021.6

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  • Association between geriatric nutritional risk index and stroke risk in hemodialysis patients: 10-Years outcome of the Q-Cohort study. International journal

    Shoji Tsuneyoshi, Yuta Matsukuma, Yasuhiro Kawai, Hiroto Hiyamuta, Shunsuke Yamada, Hiromasa Kitamura, Shigeru Tanaka, Masatomo Taniguchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Atherosclerosis   323   30 - 36   2021.4

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    DOI: 10.1016/j.atherosclerosis.2021.03.006

  • Association between geriatric nutritional risk index and stroke risk in hemodialysis patients: 10-Years outcome of the Q-Cohort study. Invited Reviewed International journal

    Tsuneyoshi S, Matsukuma Y, Kawai Y, Hiyamuta H, Yamada S, Kitamura H, Tanaka S, Taniguchi M, Tsuruya K, Nakano T, Kitazono T.

    Atherosclerosis.   2021.4

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  • Significance of revised criteria for chronic active T cell-mediated rejection in the 2017 Banff classification: Surveillance by 1-year protocol biopsies for kidney transplantation. International journal

    Kaneyasu Nakagawa, Akihiro Tsuchimoto, Kenji Ueki, Yuta Matsukuma, Yasuhiro Okabe, Kosuke Masutani, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Masafumi Nakamura, Toshiaki Nakano, Kazunari Tanabe, Takanari Kitazono

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons   21 ( 1 )   174 - 185   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ajt.16093

  • Development and validation of a risk score for the prediction of cardiovascular disease in living donor kidney transplant recipients. International journal

    Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Kaneyasu Nakagawa, Hiroaki Tsujikawa, Kosuke Masutani, Shigeru Tanaka, Keizo Kaku, Hiroshi Noguchi, Yasuhiro Okabe, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Masafumi Nakamura, Kazuhiko Tsuruya, Toshiaki Nakano, Kazunari Tanabe, Takanari Kitazono

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   36 ( 2 )   365 - 374   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfaa275

  • Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study.

    Akiko Fukui, Masaru Nakayama, Shigeru Tanaka, Yuta Matsukuma, Ryota Yoshitomi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Clinical and experimental nephrology   25 ( 1 )   9 - 18   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-020-01950-4

  • Significance of revised criteria for chronic active T cell-mediated rejection in the 2017 Banff classification: Surveillance by 1-year protocol biopsies for kidney transplantation. Invited Reviewed International journal

    Nakagawa K, Tsuchimoto A, Ueki K, Matsukuma Y, Okabe Y, Masutani K, Unagami K, Kakuta Y, Okumi M, Nakamura M, Nakano T, Tanabe K, Kitazono T; Japan Academic Consortium of Kidney Transplantation Investigators.

    Am J Transplant.   21 ( 1 )   174 - 185   2021.1

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  • Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study. Invited Reviewed International journal

    Fukui A, Nakayama M, Tanaka S, Matsukuma Y, Yoshitomi R, Nakano T, Tsuruya K, Kitazono T.

    Clin Exp Nephrol.   25 ( 1 )   9 - 18   2021.1

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  • Development and validation of a risk score for the prediction of cardiovascular disease in living donor kidney transplant recipients. Invited Reviewed International journal

    Ueki K, Tsuchimoto A, Matsukuma Y, Nakagawa K, Tsujikawa H, Masutani K, Tanaka S, Kaku K, Noguchi H, Okabe Y, Unagami K, Kakuta Y, Okumi M, Nakamura M, Tsuruya K, Nakano T, Tanabe K, Kitazono T; Japan Academic Consortium of Kidney Transplantation investigators.

    Nephrol Dial Transplant.   36 ( 2 )   365 - 374   2021.1

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  • Neurological Disorders Identified during Treatment of a SARS-CoV-2 Infection. Invited Reviewed International journal

    Wada S, Nagasaki Y, Arimizu Y, Shimo M, Matsukuma Y, Okamoto M, Yoshida S, Ohashi I, Hashimoto G, Kuwashiro T, Yasaka M, Okada Y.

    Intern Med.   59 ( 17 )   2187 - 2189   2020.9

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  • Survival comparison between superficialization of the brachial artery and tunneled central venous catheter placement in hemodialysis patients with heart failure: A retrospective study. Invited Reviewed International journal

    Nakagawa K, Yamada S, Matsukuma Y, Nakano T, Mitsuiki K.

    Ther Apher Dial.   24 ( 4 )   408 - 415   2020.8

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  • Utility of Columbia classification in focal segmental glomerulosclerosis: renal prognosis and treatment response among the pathological variants. International journal

    Akihiro Tsuchimoto, Yuta Matsukuma, Kenji Ueki, Shigeru Tanaka, Kosuke Masutani, Kaneyasu Nakagawa, Koji Mitsuiki, Noriko Uesugi, Ritsuko Katafuchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   35 ( 7 )   1219 - 1227   2020.7

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    DOI: 10.1093/ndt/gfy374

  • Utility of Columbia classification in focal segmental glomerulosclerosis: renal prognosis and treatment response among the pathological variants. Invited Reviewed International journal

    Tsuchimoto A, Matsukuma Y, Ueki K, Tanaka S, Masutani K, Nakagawa K, Mitsuiki K, Uesugi N, Katafuchi R, Tsuruya K, Nakano T, Kitazono T.

    Nephrol Dial Transplant.   1 ( 35 )   1219 - 1227   2020.7

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  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A > G mutation in a 76-year-old woman. International journal

    412   116791 - 116791   2020.5

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    DOI: 10.1016/j.jns.2020.116791

  • Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease: a cross-sectional study. International journal

    Yui Arita, Masaru Nakayama, Yuta Matsukuma, Ryota Yoshitomi, Makiko Seki, Akiko Fukui, Susumu Tsuda, Yuri Sonoda, Rina Imazu, Kimika Arakawa, Mitsuhiro Tominaga, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    BMC nephrology   21 ( 1 )   203 - 203   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12882-020-01864-z

  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A > G mutation in a 76-year-old woman. Invited Reviewed International journal

    Ueki K, Wakisaka Y, Nakamura K, Shono Y, Wada S, Yoshikawa Y, Matsukuma Y, Uchiumi T, Kang D, Kitazono T, Ago T.

    J Neurol Sci.   412 ( 116791 )   2020.5

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  • Effect of renin-angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan.

    Akihiro Tsuchimoto, Kosuke Masutani, Kenji Ueki, Kaneyasu Nakagawa, Yuta Matsukuma, Shigeru Tanaka, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Hiroshi Noguchi, Keizo Kaku, Yasuhiro Okabe, Toshiaki Nakano, Takanari Kitazono, Masafumi Nakamura, Hideki Ishida, Kazunari Tanabe

    Clinical and experimental nephrology   24 ( 4 )   369 - 378   2020.4

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    DOI: 10.1007/s10157-019-01827-1

  • Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients. International journal

    Hiroaki Tsujikawa, Shigeru Tanaka, Masatoshi Hara, Yasuhiro Kawai, Yuta Matsukuma, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   24 ( 2 )   202 - 207   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1744-9987.12865

  • Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients. Invited Reviewed International journal

    Tsujikawa H, Tanaka S, Hara M, Kawai Y, Matsukuma Y, Torisu K, Nakano T, Tsuruya K, Kitazono T.

    Ther Apher Dial.   24 ( 2 )   202 - 207   2020.4

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  • Effect of renin-angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan. Invited Reviewed International journal

    Tsuchimoto A, Masutani K, Ueki K, Nakagawa K, Matsukuma Y, Tanaka S, Unagami K, Kakuta Y, Okumi M, Noguchi H, Kaku K, Okabe Y, Nakano T, Kitazono T, Nakamura M, Ishida H, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.

    Clin Exp Nephrol.   24 ( 4 )   369 - 378   2020.4

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  • Hypocomplementemic urticarial vasculitis syndrome with gastrointestinal vasculitis and crescentic membranoproliferative glomerulonephritis without immune complex deposits.

    Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Kumiko Torisu, Kiichiro Fujisaki, Takehiro Torisu, Yuichi Yamada, Yoshinao Oda, Kosuke Masutani, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CEN case reports   9 ( 1 )   30 - 35   2020.2

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    DOI: 10.1007/s13730-019-00421-4

  • Hypocomplementemic urticarial vasculitis syndrome with gastrointestinal vasculitis and crescentic membranoproliferative glomerulonephritis without immune complex deposits. Invited Reviewed International journal

    Ueki K, Tsuchimoto A, Matsukuma Y, Torisu K, Fujisaki K, Torisu T, Yamada Y, Oda Y, Masutani K, Nakano T, Tsuruya K, Kitazono T.

    CEN Case Rep.   9 ( 1 )   30 - 35   2020.2

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  • Comparison of Immunohistochemical Staining for Large T Antigen and Capsid Protein VP1 in BK Polyomavirus-Associated Nephropathy. Invited Reviewed International journal

    Masutani K, Matsukuma Y, Tsuchimoto A, Okabe Y, Doi A, Kaku K, Nakamura M, Nakano T, Tsuruya K, Kitazono T.

    Nephron.   144   28 - 36   2020.1

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  • Development and validation of a new prediction model for graft function using preoperative marginal factors in living-donor kidney transplantation.

    Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Toshiaki Nakano, Yasuhiro Okabe, Yoichi Kakuta, Masayoshi Okumi, Kazuhiko Tsuruya, Masafumi Nakamura, Takanari Kitazono, Kazunari Tanabe

    Clinical and experimental nephrology   23 ( 11 )   1331 - 1340   2019.11

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    DOI: 10.1007/s10157-019-01774-x

  • Development and validation of a new prediction model for graft function using preoperative marginal factors in living-donor kidney transplantation Invited Reviewed International journal

    Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Nakano T, Okabe Y, Kakuta Y, Okumi M, Tsuruya K, Nakamura M, Kitazono T, Tanabe K.

    Clin Exp Nephrol   23 ( 11 )   1331 - 1340   2019.11

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  • Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus-associated Nephropathy. International journal

    Kosuke Masutani, Akihiro Tsuchimoto, Yuta Matsukuma, Shigeru Tanaka, Keizo Kaku, Hiroshi Noguchi, Kei Kurihara, Yasuhiro Okabe, Toshiaki Nakano, Kazuhiko Tsuruya, Hitoshi Nakashima, Masafumi Nakamura, Takanari Kitazono

    Transplantation proceedings   51 ( 5 )   1410 - 1414   2019.6

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    DOI: 10.1016/j.transproceed.2019.01.129

  • Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus-associated Nephropathy. Invited Reviewed International journal

    Masutani K, Tsuchimoto A, Matsukuma Y, Tanaka S, Kaku K, Noguchi H, Kurihara K, Okabe Y, Nakano T, Tsuruya K, Nakashima H, Nakamura M, Kitazono T.

    Transplant Proc.   51 ( 5 )   1410 - 1414   2019.6

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  • Rapidly Progressive Glomerulonephritis with Delayed Appearance of Anti-Glomerular Basement Membrane Antibody Successfully Treated with Multiple Courses of Steroid Pulse Therapy. Invited Reviewed International journal

    Toyota S, Eriguchi M, Hasegawa S, Ueki K, Matsukuma Y, Tsuchimoto A, Fujisaki K, Torisu K, Tsuruya K, Nakano T, Kitazono T.

    Case Rep Nephrol Dial.   16 ( 9 )   25 - 32   2019.4

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  • Development of a risk prediction model for infection-related mortality in patients undergoing peritoneal dialysis. Invited Reviewed International journal

    Tsujikawa H, Tanaka S, Matsukuma Y, Kanai H, Torisu K, Nakano T, Tsuruya K, Kitazono T.

    PLoS One.   2019.3

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  • Thrombotic microangiopathy associated with anticardiolipin antibody in a kidney transplant recipient with polycythemia.

    Akihiro Tsuchimoto, Yuta Matsukuma, Kenji Ueki, Takehiro Nishiki, Atsushi Doi, Yasuhiro Okabe, Masafumi Nakamura, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono, Kosuke Masutani

    CEN case reports   8 ( 1 )   1 - 7   2019.2

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    DOI: 10.1007/s13730-018-0354-x

  • Association of geriatric nutritional risk index with infection-related mortality in patients undergoing hemodialysis: The Q-Cohort Study. International journal

    Yuta Matsukuma, Shigeru Tanaka, Masatomo Taniguchi, Toshiaki Nakano, Kosuke Masutani, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya

    Clinical nutrition (Edinburgh, Scotland)   38 ( 1 )   279 - 287   2019.2

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    DOI: 10.1016/j.clnu.2018.01.019

  • Thrombotic microangiopathy associated with anticardiolipin antibody in a kidney transplant recipient with polycythemia. Invited Reviewed International journal

    Tsuchimoto A, Matsukuma Y, Ueki K, Nishiki T, Doi A, Okabe Y, Nakamura M, Tsuruya K, Nakano T, Kitazono T, Masutani K.

    CEN Case Rep.   8 ( 1 )   1 - 7   2019.2

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  • Association of geriatric nutritional risk index with infection-related mortality in patients undergoing hemodialysis: The Q-Cohort Study. Invited Reviewed International journal

    Matsukuma Y, Tanaka S, Taniguchi M, Nakano T, Masutani K, Hirakata H, Kitazono T, Tsuruya K.

    Clin Nutr   38 ( 1 )   279 - 287   2019.2

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  • Effect of steroid pulse therapy on post-transplant immunoglobulin A nephropathy. International journal

    Yuta Matsukuma, Kosuke Masutani, Akihiro Tsuchimoto, Yasuhiro Okabe, Masafumi Nakamura, Takanari Kitazono, Kazuhiko Tsuruya

    Nephrology (Carlton, Vic.)   23 Suppl 2   10 - 16   2018.7

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    DOI: 10.1111/nep.13272

  • Effect of steroid pulse therapy on post-transplant immunoglobulin A nephropathy Invited Reviewed International journal

    Matsukuma Y, Masutani K, Tsuchimoto A, Okabe Y, Nakamura M, Kitazono T, Tsuruya K.

    Nephrology (Carlton)   23   10 - 16   2018.6

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  • Association between serum uric acid level and renal arteriolar hyalinization in individuals without chronic kidney disease. Invited Reviewed International journal

    Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Haruyama N, Okabe Y, Nakamura M, Tsuruya K, Kitazono T.

    Atherosclerosis   ( 266 )   121 - 127   2017.11

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  • Association between serum uric acid level and renal arteriolar hyalinization in individuals without chronic kidney disease. International journal

    Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Naoki Haruyama, Yasuhiro Okabe, Masafumi Nakamura, Kazuhiko Tsuruya, Takanari Kitazono

    Atherosclerosis   266   121 - 127   2017.11

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    DOI: 10.1016/j.atherosclerosis.2017.09.017

  • The potential role of perivascular lymphatic vessels in preservation of kidney allograft function.

    Akihiro Tsuchimoto, Toshiaki Nakano, Shoko Hasegawa, Kosuke Masutani, Yuta Matsukuma, Masahiro Eriguchi, Masaharu Nagata, Takehiro Nishiki, Hidehisa Kitada, Masao Tanaka, Takanari Kitazono, Kazuhiko Tsuruya

    Clinical and experimental nephrology   21 ( 4 )   721 - 731   2017.8

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    DOI: 10.1007/s10157-016-1338-9

  • A J-shaped association between serum uric acid levels and poor renal survival in female patients with IgA nephropathy. Invited Reviewed International journal

    Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Fujisaki K, Torisu K, Katafuchi R, Hirakata H, Tsuruya K, Kitazono T.

    Hypertens Res.   40 ( 3 )   291 - 297   2017.3

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  • A J-shaped association between serum uric acid levels and poor renal survival in female patients with IgA nephropathy. International journal

    Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Ritsuko Katafuchi, Hideki Hirakata, Kazuhiko Tsuruya, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   40 ( 3 )   291 - 297   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/hr.2016.134

  • Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease. International journal

    Kenji Ueki, Yuta Matsukuma, Kosuke Masutani, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Shigeru Tanaka, Tamotsu Kiyoshima, Satoshi Hisano, Takanari Kitazono, Kazuhiko Tsuruya

    BMC nephrology   16   173 - 173   2015.10

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    DOI: 10.1186/s12882-015-0164-8

  • Temporal serum creatinine increase and exacerbation of tubulointerstitial inflammation during the first two months in resolving polyomavirus BK nephropathy. International journal

    Kosuke Masutani, Akihiro Tsuchimoto, Yuta Matsukuma, Kei Kurihara, Takehiro Nishiki, Hidehisa Kitada, Masao Tanaka, Takanari Kitazono, Kazuhiko Tsuruya

    Nephrology (Carlton, Vic.)   20 Suppl 2   45 - 50   2015.7

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    DOI: 10.1111/nep.12462

  • A case of bacterial peritonitis caused by Roseomonas mucosa in a patient undergoing continuous ambulatory peritoneal dialysis.

    Yuta Matsukuma, Koji Sugawara, Shota Shimano, Shunsuke Yamada, Kazuhiko Tsuruya, Takanari Kitazono, Harumichi Higashi

    CEN case reports   3 ( 2 )   127 - 131   2014.11

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    DOI: 10.1007/s13730-013-0101-2

  • Early disappearance of urinary decoy cells in successfully treated polyomavirus BK nephropathy. Invited Reviewed International journal

    Matsukuma Y, Masutani K, Tsuchimoto A, Okabe Y, Kitada H, Noguchi H, Tanaka M, Tsuruya K, Kitazono T.

    Transplant Proc.   46 ( 2 )   560 - 563   2014.5

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Presentations

  • 移植後IgA腎症に対するステロイドパルス療法の長期効果の検討

    松隈祐太、升谷耕介、植木研次、安宅映里、土本晃裕、岡部安博、北園孝成、中野敏昭

    第56回臨床腎移植学会  2023.2 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 慢性活動性T細胞関連拒絶の病理所見と治療経過について Invited

    松隈祐太、野口浩司、中川兼康、安宅映里、植木研次、土本晃裕、加来啓三、岡部安博 、升谷耕介、北園孝成、中野敏昭

    第56回臨床腎移植学会  2023.6 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 日本人慢性腎臓病(CKD)での尿中ナトリウム(Na)/カリウム(K)比と治療抵抗性高血圧(ATRH)の関係:福岡腎臓病データベース研究

    松隈祐太,中山勝,田中茂,北村博雅,鶴屋和彦,北園孝成,中野敏昭

    第65回日本腎臓学会学術集会  2022.6 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • 移植後IgA腎症に対するステロイドパルス療法の検討

    松隈祐太、升谷耕介、植木研次、安宅映里、土本晃裕、岡部安博 、北園孝成、中野敏昭

    第67回日本透析医学会学術集会・総会  2022.6 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 慢性腎臓病における尿中Na/K比と腎死および総死亡の関係, 第63回日本腎臓学会学術総会, 2020年8月19日-21日

    松隈祐太、園田有理、津田晋、関雅紀子、福井明子、吉富亮太、中山勝

    2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Country:Japan  

  • 膵神経内分泌腫瘍へのエベロリムス投与中に発症したネフローゼ症候群の一例

    南 優希, 高波 百合那, 松隈 祐太, 恒吉 章治, 山田 俊輔, 藤森 尚, 小川 佳宏, 中野 敏昭, 北園 孝成

    日本腎臓学会誌  2023.9  (一社)日本腎臓学会

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  • 腎移植における内科医の役割 腎移植後の内科管理

    松隈 祐太

    日本腎臓学会誌  2024.6  (一社)日本腎臓学会

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  • 腎生検により診断に至った全身性サルコイドーシスの一例

    諸富 響, 岩田 寛子, 長嶋 昭憲, 原口 哲郎, 明石 道昭, 安宅 映里, 松隈 祐太

    日赤医学  2023.10  日本赤十字社医学会

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  • 腎提供4年後にANCA関連腎炎を発症した腎移植ドナーの1例

    園田 愼一郎, 水戸 実希, 古原 千明, 松隈 祐太, 中野 敏昭, 北園 孝成

    日本腎臓学会誌  2022.10  (一社)日本腎臓学会

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  • 肝移植後ネフローゼ症候群12症例の臨床病理学的研究

    松隈 祐太, 植木 研次, 岡本 悠史, 安宅 映里, 土本 晃裕, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2024.6  (一社)日本腎臓学会

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  • 糖尿病罹患歴の長い患者に微小変化型ネフローゼ症候群が発症した一例

    松本 英展, 西田 明弘, 竹内 実芳, 福満 研人, 中俣 悠亮, 牟田 隆則, 植木 研次, 松隈 祐太, 藤崎 毅一郎

    日本腎臓学会誌  2023.9  (一社)日本腎臓学会

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  • 移植後IgA腎症に対するステロイドパルス療法の長期効果の検討

    松隈 祐太, 升谷 耕介, 植木 研次, 安宅 映里, 土本 晃裕, 岡部 安博, 北園 孝成, 中野 敏昭

    日本透析医学会雑誌  2022.5  (一社)日本透析医学会

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  • 移植後IgA腎症に対するステロイドパルス療法の検討

    第67回日本透析医学会学術集会・総会  2022.6 

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  • 移植後IgA腎症に対するステロイドパルス療法の 長期効果の検討

    第 56 回日本臨床腎移植学会  2023.2 

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  • 生体腎移植後の早期ARB内服開始に関する安全性・有効性の検討

    久保 進祐, 野口 浩司, 佐藤 優, 目井 孝典, 植木 研次, 松隈 祐太, 加来 啓三, 岡部 安博, 中村 雅史

    移植  2022.10  (一社)日本移植学会

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  • 治療の進歩に伴う関節リウマチ合併腎疾患の変遷

    植木 研次, 松隈 祐太, 安宅 映里, 岡本 悠史, 土本 晃裕, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2024.6  (一社)日本腎臓学会

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  • 日本人慢性腎臓病(CKD)での尿中ナトリウム(Na)/カリウム(K)比と治療抵抗性高血圧(ATRH)の関係:福岡腎臓病データベース研究

    第65回日本腎臓学会学術総会  2022.6 

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  • 日本人CKD患者における尿酸と慢性腎臓病の進展の関係 福岡腎臓病データベース研究

    松隈 祐太, 田中 茂, 冷牟田 浩人, 北村 博雅, 鶴屋 和彦, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2023.5  (一社)日本腎臓学会

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  • 慢性腎臓病患者における尿中Na/K比と治療抵抗性高血圧の関連 福岡腎臓病データベース(FKR)研究

    松隈 祐太, 中山 勝, 田中 茂, 北村 博雅, 鶴屋 和彦, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2022.5  (一社)日本腎臓学会

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  • 慢性活動性T細胞関連拒絶の 病理所見と治療経過について Invited

    第 56 回日本臨床腎移植学会  2023.2 

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  • 慢性活動性T細胞性拒絶反応(CA-TCMR)への治療が移植腎予後へ与える影響

    野口 浩司, 松隈 祐太, 植木 研次, 土本 晃裕, 加来 啓三, 岡部 安博, 中村 雅史

    移植  2023.9  (一社)日本移植学会

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  • 当院における難治性ネフローゼに対するリツキシマブの長期使用成績

    岩本 早紀, 植木 研次, 松隈 祐太, 山田 俊輔, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2023.5  (一社)日本腎臓学会

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  • 当院における腎移植後妊娠出産に至った16例の検討

    岡本 悠史, 安宅 映里, 植木 研次, 松隈 祐太, 土本 晃裕, 升谷 耕介, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2024.6  (一社)日本腎臓学会

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  • 定期生検における瘢痕部炎症(i-IFTA)の持続/増悪と移植腎予後の関係

    安宅 映里, 岡本 悠史, 植木 研次, 松隈 祐太, 野口 浩司, 土本 晃裕, 岡部 安博, 升谷 耕介, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2024.6  (一社)日本腎臓学会

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  • BKウイルス腎症の病理所見と時代推移の検討

    松隈 祐太, 安宅 映里, 植木 研次, 土本 晃裕, 野口 浩司, 加来 啓三, 岡部 安博, 升谷 耕介, 中村 雅史, 北園 孝成, 中野 敏昭

    日本臨床腎移植学会プログラム・抄録集  2024.2  (一社)日本臨床腎移植学会

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    Language:Japanese  

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MISC

  • 【高尿酸血症2024-基礎・臨床の最新知見-】高尿酸血症の臨床 高尿酸血症の治療 薬物療法 尿アルカリ化薬

    松隈 祐太

    日本臨床   82 ( 6 )   903 - 906   2024.6   ISSN:0047-1852

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  • 1. 松隈 祐太、鶴屋和彦、「感染症に伴う糸球体病変:B型肝炎・C型肝炎関連腎症」、腎疾患・透析最新の治療2014-2016、p160-163 2. 松隈 祐太、鶴屋和彦、「2.透析医療における観察研究 1 DOPPS ② DOPPS の成果─透析処方─」、透析療法ネクストX VIII、医学図書出版、東京、2014年 Reviewed

    1. 松隈祐太、鶴屋和彦 2. 松隈祐太、鶴屋和彦

    2021.5

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Professional Memberships

  • 日本内科学会、日本腎臓学会、日本透析医学会、日本臨床腎移植学会

Research Projects

  • 移植腎病理に新規尿中バイオマーカーを組み合わせた予後予測モデルの開発

    Grant number:23K15787  2023 - 2025

    日本学術振興会  科学研究費助成事業  若手研究

    松隈 祐太

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    Grant type:Scientific research funding

    移植後の腎機能障害の原因診断に移植腎生検は有用である。その一方で、侵襲性があるため、繰り返しの施行に限界があり、代替的な評価方法の確立は喫緊の課題である。新規尿中バイオマーカー及び尿中エクソソームを用いたリキッドバイオプシーは非侵襲的で、今後の臨床応用が期待されている。本研究では、
    ①新規尿中バイオマーカー及び尿中エクソソームを用いたリキッドバイオプシーと、移植腎生検所見との横断的な関係を評価し、潜在的な組織障害との関連を評価する。
    ②さらに腎予後との関係を評価し、臨床所見に新規マーカーを組み込んだ予測モデルの作成を行い、予後予測能が改善するかを評価する。

    CiNii Research

Class subject

  • 腎臓生理学 I

    2023.4 - 2023.9   First semester

  • 臨床医学 IV 腎・泌尿生殖器概論 医歯薬合同講義

    2023.4 - 2023.9   First semester

  • 保健学科検査技術科学専攻 生理機能検査学

    2023.4 - 2023.9   First semester

  • 保健学科検査技術科学専攻 生理機能検査学

    2022.4 - 2022.9   First semester

  • 臨床医学 IV 腎・泌尿生殖器概論 医歯薬合同講義

    2022.4 - 2022.9   First semester

  • 腎臓生理学 I

    2022.4 - 2022.9   First semester

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Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Nephrology