GOYA TAKESHI
Organization
Kyushu University Hospital Department of Hepatology and Pancreatology Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Profile
九州大学病院 肝臓・膵臓・胆道内科にて診療・研究・教育活動に従事している。
診療面ではウイルス性・代謝性・自己免疫性の各種肝障害、肝硬変、肝癌に対する診療を行っている。
研究面では肝再生の病態解明を中心に検討を行っている。
教育面では大学院生・病棟医員・臨床研修医・医学部学生に対する指導・講義を行っている。
External link
Research Interests・Research Keywords
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Research theme：acute liver failure
Keyword：acute liver failure, hepatocyte, liver regeneration
Research period： 2020.4 - 2023.5
Papers
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Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha. International journal
Koji Imoto, Masatake Tanaka, Takeshi Goya, Yuki Azuma, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
Medicine 102 ( 45 ) e35931 2023.11
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Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury.
Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Yoshihiro Ogawa
Internal medicine (Tokyo, Japan) 2023.6
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FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama
Cell Reports 42 ( 5 ) 112530 - 112530 2023.5
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Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure. International journal
Akifumi Kuwano, Tasuku Okui, Motoyuki Kohjima, Miho Kurokawa, Takeshi Goya, Masatake Tanaka, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Nobuhiro Fujita, Yasuhiro Ushijima, Kousei Ishigami, Shoji Tokunaga, Masaki Kato, Yoshihiro Ogawa
Medicine 102 ( 10 ) e33090 2023.3
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Elevated Pancreatic Enzymes Associated with Acute Liver Injury Were Mediated by Tumor Necrosis Factor-Alpha Signaling Reviewed
Takeshi Goya, Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
Hepatitis Monthly 22 ( 1 ) 2022.8
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Direct Conversion of Human Endothelial Cells Into Liver Cancer‐Forming Cells Using Nonintegrative Episomal Vectors Reviewed International journal
6 ( 7 ) 1725 - 1740 2022.7
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Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency. International journal
Koji Imoto, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Shigeki Tashiro, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
BMC gastroenterology 22 ( 1 ) 144 - 144 2022.3
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Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation. International journal
Shigeki Tashiro, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Miho Kurokawa, Koji Imoto, Akifumi Kuwano, Motoi Takahashi, Hideo Suzuki, Motoyuki Kohjima, Masaki Kato, Yoshihiro Ogawa
Toxicology and applied pharmacology 434 115817 - 115817 2022.1
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The Efficacy of Tofogliflozin on Metabolic Dysfunction-Associated Fatty Liver Disease Reviewed
Takeshi Goya, Koji Imoto, Shigeki Tashiro, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
Gastroenterology Insights 13 ( 1 ) 20 - 26 2022.1
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The Combination of Nucleotide Analog Therapy and Steroid Pulse Therapy for Acute HBV Infection Effectively Promotes HBV Clearance Reviewed
Takeshi Goya, Tomoyuki Kurashige, Miho Kurokawa, Masatake Tanaka, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa
Gastroenterology Insights 13 ( 1 ) 1 - 8 2021.12
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Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified International journal
Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa
BMC Gastroenterology 21 ( 1 ) 73 - 73 2021.12
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Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients. International journal
Akifumi Kuwano, Masatake Tanaka, Hideo Suzuki, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Takeshi Goya, Motoyuki Kohjima, Masaki Kato, Yoshihiro Ogawa
Biochemistry and biophysics reports 27 101068 - 101068 2021.9
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Hypoxic hepatitis with marked elevation of serum ferritin probably due to activation of intrahepatic macrophages: another form of hypoxic hepatitis hitherto not reported?
M Tanaka, T Goya, H Suzuki, M Takahashi, K Imoto, M Kurokawa, S Tashiro, A Kuwano, S Okada, M Kato, M Kohjima, K Kotoh, Y Ogawa
Acta Gastro Enterologica Belgica 84 ( 2 ) 317 - 320 2021.6
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Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma International journal
Hideo Suzuki, Motoyuki Kohjima, Masatake Tanaka, Takeshi Goya, Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori, Mariko Tsuda, Motoi Takahashi, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Akifumi Kuwano, Masaki Kato, Seiji Okada, Makoto Nakamuta, Yoshihiro Ogawa
Canadian Journal of Gastroenterology and Hepatology 2021 1 - 13 2021.2
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Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells Reviewed
Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki
Nature Communications 11 ( 1 ) 2020.12
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Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma Reviewed International journal
Masayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Takeshi Goya, Kenta Motomura, Motoyuki Kohjima, Masaki Kato, Akihide Masumoto, Kazuhiro Kotoh
World Journal of Gastroenterology 23 ( 29 ) 5379 - 5379 2017.8
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Novel methods for the treatment of liver fibrosis using in vivo direct reprogramming technology Reviewed
Takeshi Goya, Atsushi Suzuki
Stem Cell Investigation 3 92 - 92 2016.12
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Portal Vein Thrombosis Repeatedly Observed in a Cirrhotic Patient with Antiphospholipid Antibody Syndrome Reviewed
Mari Ohe, Taishi Mutsuki, Takeshi Goya, Shinsaku Yamashita, Takeaki Satoh, Motoyuki Kohjima, Masaki Kato
Fukuoka Igaku Zasshi 107 ( 10 ) 185 - 190 2016.10
Presentations
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当科における急性肝不全に対する内科的治療：ステロイド肝動注療法の有用性
合谷孟、井本効志、田中正剛
第60回日本腹部救急医学会総会 2024.3
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NASHモデルマウスにおける肝線維化機序の解明
井本効志、東夕喜、大野あかり、青柳知美、高橋基、黒川美穂、合谷孟、田中正剛、国府島庸之、小川佳宏
第５９回日本肝臓学会総会 2023.6
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急性肝障害での類洞血流障害におけるIFNγの関与
#黒川美穂,合谷孟、国府島庸之
第５９回 日本肝臓学会総会 2023.6
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組織学的な診断の得られた、免疫チェックポイント阻害剤による肝障害の臨床的特徴
日置智惟、@東夕喜、@大野あかり、#青柳知美、#高橋基、#黒川美穂、井本効志、合谷孟、田中正剛、@国府島庸之、小川佳宏
第５９回日本肝臓学会総会 2023.6
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肝非実質細胞を介した閉経後NASHの発症増悪メカニズム
合谷孟、#青柳友美、@鈴木秀生、@東夕喜、#日置智惟、#高橋基、井本効志、#黒川美穂、@田代茂樹、田中正剛、@国府島庸之、小川佳宏
第５９回日本肝臓学会総会 2023.6
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リンパうっ滞がフォンタン関連肝疾患の肝線維化に及ぼす影響についての基礎的検討
田中正剛、@東夕喜、#日置智惟、#青柳知美、#高橋基、井本効志、#黒川美穂、合谷孟、@国府島庸之、小川佳宏
第５９回日本肝臓学会総会 2023.6
Professional Memberships
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日本内科学会
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日本肝臓学会
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日本消化器病学会
Research Projects
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Extracellular Trapsに着目した肝障害の炎症プロセスの解明
Grant number：22K16021 2022 - 2025
日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Grant type：Scientific research funding
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喫煙が肝障害時の肝細胞の可塑性、多様性に及ぼす影響の解明
2021 - 2023
公益財団法人喫煙科学研究財団・若手研究
Authorship：Principal investigator Grant type：Contract research
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成熟肝細胞の脱分化に着目した肝再生機構の解明
Grant number：20K22877 2020 - 2021
日本学術振興会 科学研究費助成事業 研究活動スタート支援
Authorship：Principal investigator Grant type：Scientific research funding
Class subject
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臨床診断学
2023.10 - 2024.3 Second semester
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希少がんを含む各種がんの治療
2023.10 - 2024.3 Second semester
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保健学科検査技術科学３年生 生理機能検査学 腹部超音波検査
2023.4 - 2023.9 First semester
Other educational activity and Special note
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2023 Class Teacher
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2023 Class Teacher
Outline of Social Contribution and International Cooperation activities
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臨床研究・基礎研究で得られた成果を学会・研究会で発表、論文として投稿することで社会に発信し貢献している。
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Gastroenterology
肝臓疾患
Clinician qualification
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Specialist
The Japan Society of Hepatology（JSH）
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Specialist
The Japanese Society of Gastroenterology（JSGE）
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Certifying physician
The Japanese Society of Internal Medicine（JSIM）
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総合内科専門医
The Japanese Society of Internal Medicine（JSIM）
Year of medical license acquisition
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2009
Notable Clinical Activities
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急性肝障害の中でも特に重篤な急性肝不全については、多数例の症例の治療を行なってきており、病状に応じた適切な治療を提供し高い効果を得ている。