Updated on 2024/07/28

Information

 

写真a

 
GOYA TAKESHI
 
Organization
Kyushu University Hospital Department of Hepatology and Pancreatology Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Profile
九州大学病院 肝臓・膵臓・胆道内科にて診療・研究・教育活動に従事している。 診療面ではウイルス性・代謝性・自己免疫性の各種肝障害、肝硬変、肝癌に対する診療を行っている。 研究面では肝再生の病態解明を中心に検討を行っている。 教育面では大学院生・病棟医員・臨床研修医・医学部学生に対する指導・講義を行っている。
External link

Research Interests・Research Keywords

  • Research theme:acute liver failure

    Keyword:acute liver failure, hepatocyte, liver regeneration

    Research period: 2020.4 - 2023.5

Papers

  • Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha. International journal

    Koji Imoto, Masatake Tanaka, Takeshi Goya, Yuki Azuma, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Medicine   102 ( 45 )   e35931   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000035931

  • Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury.

    Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Yoshihiro Ogawa

    Internal medicine (Tokyo, Japan)   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.2043-23

  • FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation

    Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama

    Cell Reports   42 ( 5 )   112530 - 112530   2023.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2023.112530

  • Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure. International journal

    Akifumi Kuwano, Tasuku Okui, Motoyuki Kohjima, Miho Kurokawa, Takeshi Goya, Masatake Tanaka, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Nobuhiro Fujita, Yasuhiro Ushijima, Kousei Ishigami, Shoji Tokunaga, Masaki Kato, Yoshihiro Ogawa

    Medicine   102 ( 10 )   e33090   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000033090

  • Elevated Pancreatic Enzymes Associated with Acute Liver Injury Were Mediated by Tumor Necrosis Factor-Alpha Signaling Reviewed

    Takeshi Goya, Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Hepatitis Monthly   22 ( 1 )   2022.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.5812/hepatmon-128106

  • Direct Conversion of Human Endothelial Cells Into Liver Cancer‐Forming Cells Using Nonintegrative Episomal Vectors Reviewed International journal

    6 ( 7 )   1725 - 1740   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    Liver cancer is an aggressive cancer associated with a poor prognosis. Development of therapeutic strategies for liver cancer requires fundamental research using suitable experimental models. Recent progress in direct reprogramming technology has enabled the generation of many types of cells that are difficult to obtain and provide a cellular resource in experimental models of human diseases. In this study, we aimed to establish a simple one-step method for inducing cells that can form malignant human liver tumors directly from healthy endothelial cells using nonintegrating episomal vectors. To screen for factors capable of inducing liver cancer-forming cells (LCCs), we selected nine genes and one short hairpin RNA that suppresses tumor protein p53 (TP53) expression and introduced them into human umbilical vein endothelial cells (HUVECs), using episomal vectors. To identify the essential factors, we examined the effect of changing the amounts and withdrawing individual factors. We then analyzed the proliferation, gene and protein expression, morphologic and chromosomal abnormality, transcriptome, and tumor formation ability of the induced cells. We found that a set of six factors, forkhead box A3 (FOXA3), hepatocyte nuclear factor homeobox 1A (HNF1A), HNF1B, lin-28 homolog B (LIN28B), MYCL proto-oncogene, bHLH transcription factor (L-MYC), and Kruppel-like factor 5 (KLF5), induced direct conversion of HUVECs into LCCs. The gene expression profile of these induced LCCs (iLCCs) was similar to that of human liver cancer cells, and these cells effectively formed tumors that resembled human combined hepatocellular-cholangiocarcinoma following transplantation into immunodeficient mice. Conclusion: We succeeded in the direct induction of iLCCs from HUVECs by using nonintegrating episomal vectors. iLCCs generated from patients with cancer and healthy volunteers will be useful for further advancements in cancer research and for developing methods for the diagnosis, treatment, and prognosis of liver cancer.

    DOI: 10.1002/hep4.1911

  • Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency. International journal

    Koji Imoto, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Shigeki Tashiro, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    BMC gastroenterology   22 ( 1 )   144 - 144   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-022-02213-0

  • The Efficacy of Tofogliflozin on Metabolic Dysfunction-Associated Fatty Liver Disease Reviewed

    Takeshi Goya, Koji Imoto, Shigeki Tashiro, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Gastroenterology Insights   13 ( 1 )   20 - 26   2022.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/gastroent13010003

  • Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation. International journal

    Shigeki Tashiro, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Miho Kurokawa, Koji Imoto, Akifumi Kuwano, Motoi Takahashi, Hideo Suzuki, Motoyuki Kohjima, Masaki Kato, Yoshihiro Ogawa

    Toxicology and applied pharmacology   434   115817 - 115817   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.taap.2021.115817

  • Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified International journal

    Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa

    BMC Gastroenterology   21 ( 1 )   73 - 73   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-021-01656-1

  • The Combination of Nucleotide Analog Therapy and Steroid Pulse Therapy for Acute HBV Infection Effectively Promotes HBV Clearance Reviewed

    Takeshi Goya, Tomoyuki Kurashige, Miho Kurokawa, Masatake Tanaka, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Gastroenterology Insights   13 ( 1 )   1 - 8   2021.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/gastroent13010001

  • Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients. International journal

    Akifumi Kuwano, Masatake Tanaka, Hideo Suzuki, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Takeshi Goya, Motoyuki Kohjima, Masaki Kato, Yoshihiro Ogawa

    Biochemistry and biophysics reports   27   101068 - 101068   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrep.2021.101068

  • Hypoxic hepatitis with marked elevation of serum ferritin probably due to activation of intrahepatic macrophages: another form of hypoxic hepatitis hitherto not reported?

    M Tanaka, T Goya, H Suzuki, M Takahashi, K Imoto, M Kurokawa, S Tashiro, A Kuwano, S Okada, M Kato, M Kohjima, K Kotoh, Y Ogawa

    Acta Gastro Enterologica Belgica   84 ( 2 )   317 - 320   2021.6

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.51821/84.2.317

  • Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma International journal

    Hideo Suzuki, Motoyuki Kohjima, Masatake Tanaka, Takeshi Goya, Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori, Mariko Tsuda, Motoi Takahashi, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Akifumi Kuwano, Masaki Kato, Seiji Okada, Makoto Nakamuta, Yoshihiro Ogawa

    Canadian Journal of Gastroenterology and Hepatology   2021   1 - 13   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2021/8813410

  • Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells Reviewed

    Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki

    Nature Communications   11 ( 1 )   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-020-19041-z

  • Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma Reviewed International journal

    Masayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Takeshi Goya, Kenta Motomura, Motoyuki Kohjima, Masaki Kato, Akihide Masumoto, Kazuhiro Kotoh

    World Journal of Gastroenterology   23 ( 29 )   5379 - 5379   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3748/wjg.v23.i29.5379

  • Novel methods for the treatment of liver fibrosis using in vivo direct reprogramming technology Reviewed

    Takeshi Goya, Atsushi Suzuki

    Stem Cell Investigation   3   92 - 92   2016.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.21037/sci.2016.11.10

  • Portal Vein Thrombosis Repeatedly Observed in a Cirrhotic Patient with Antiphospholipid Antibody Syndrome Reviewed

    Mari Ohe, Taishi Mutsuki, Takeshi Goya, Shinsaku Yamashita, Takeaki Satoh, Motoyuki Kohjima, Masaki Kato

    Fukuoka Igaku Zasshi   107 ( 10 )   185 - 190   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

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Presentations

  • 当科における急性肝不全に対する内科的治療:ステロイド肝動注療法の有用性

    合谷孟、井本効志、田中正剛

    第60回日本腹部救急医学会総会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • NASHモデルマウスにおける肝線維化機序の解明

    井本効志、東夕喜、大野あかり、青柳知美、高橋基、黒川美穂、合谷孟、田中正剛、国府島庸之、小川佳宏

    第59回日本肝臓学会総会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Country:Japan  

  • 急性肝障害での類洞血流障害におけるIFNγの関与

    #黒川美穂,合谷孟、国府島庸之

    第59回 日本肝臓学会総会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 組織学的な診断の得られた、免疫チェックポイント阻害剤による肝障害の臨床的特徴

    日置智惟、@東夕喜、@大野あかり、#青柳知美、#高橋基、#黒川美穂、井本効志、合谷孟、田中正剛、@国府島庸之、小川佳宏

    第59回日本肝臓学会総会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Country:Japan  

  • 肝非実質細胞を介した閉経後NASHの発症増悪メカニズム

    合谷孟、#青柳友美、@鈴木秀生、@東夕喜、#日置智惟、#高橋基、井本効志、#黒川美穂、@田代茂樹、田中正剛、@国府島庸之、小川佳宏

    第59回日本肝臓学会総会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Country:Japan  

  • リンパうっ滞がフォンタン関連肝疾患の肝線維化に及ぼす影響についての基礎的検討

    田中正剛、@東夕喜、#日置智惟、#青柳知美、#高橋基、井本効志、#黒川美穂、合谷孟、@国府島庸之、小川佳宏

    第59回日本肝臓学会総会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Country:Japan  

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Professional Memberships

  • 日本内科学会

  • 日本肝臓学会

  • 日本消化器病学会

Research Projects

  • Extracellular Trapsに着目した肝障害の炎症プロセスの解明

    Grant number:22K16021  2022 - 2025

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 喫煙が肝障害時の肝細胞の可塑性、多様性に及ぼす影響の解明

    2021 - 2023

    公益財団法人喫煙科学研究財団・若手研究

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    Authorship:Principal investigator  Grant type:Contract research

  • 成熟肝細胞の脱分化に着目した肝再生機構の解明

    Grant number:20K22877  2020 - 2021

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Authorship:Principal investigator  Grant type:Scientific research funding

Class subject

  • 臨床診断学

    2023.10 - 2024.3   Second semester

  • 希少がんを含む各種がんの治療

    2023.10 - 2024.3   Second semester

  • 保健学科検査技術科学3年生 生理機能検査学 腹部超音波検査

    2023.4 - 2023.9   First semester

Other educational activity and Special note

  • 2023  Class Teacher 

  • 2023  Class Teacher 

Outline of Social Contribution and International Cooperation activities

  • 臨床研究・基礎研究で得られた成果を学会・研究会で発表、論文として投稿することで社会に発信し貢献している。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Gastroenterology

    肝臓疾患

Clinician qualification

  • Specialist

    The Japan Society of Hepatology(JSH)

  • Specialist

    The Japanese Society of Gastroenterology(JSGE)

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

  • 総合内科専門医

    The Japanese Society of Internal Medicine(JSIM)

Year of medical license acquisition

  • 2009

Notable Clinical Activities

  • 急性肝障害の中でも特に重篤な急性肝不全については、多数例の症例の治療を行なってきており、病状に応じた適切な治療を提供し高い効果を得ている。