Updated on 2024/12/04

Information

 

写真a

 
BAI XIAOPENG
 
Organization
Kyushu University Hospital Department of Hepatology and Pancreatology Assistant Professor
Kyushu University Hospital Department of Hepatology and Pancreatology(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425286
Profile
I perform basic/clinical research mainly about gastroenterology and have clinical duty in Kyushu university hospital.

Research Areas

  • Life Science / Gastroenterology

Degree

  • November 2017, Ph.D degree in internal medicine, Kyushu univerisity

  • March 2009, M.D. degree, Kyushu University

Research History

  • Kyushu University Hospital Assistant Professor

    2024.11 - Present

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  • 2011年4月-2012年3月 福岡東医療センター 消化器内科 医師 2012年4月-2013年3月 北九州市立医療センター 消化器内科 医師

    2011年4月-2012年3月 福岡東医療センター 消化器内科 医師 2012年4月-2013年3月 北九州市立医療センター 消化器内科 医師

  • 2018年3月-2021年3月 博士後研究員 McMaster university, Canada

Research Interests・Research Keywords

  • Research theme:Mechanisms of regulatory effect of microbiota bacteria on intestinal motility through innate immune system

    Keyword:microbiota, intestinal motility, innate immune system

    Research period: 2021.5 - 2023.5

  • Research theme:Effect of intestinal barrier function on central nervous system under stress conditions

    Keyword:stress, gut-brain axis, mucosal barrier function

    Research period: 2021.5 - 2023.5

Awards

  • 優秀ポスター賞

    2020.3   カナダ国消化器病学会   優秀ポスター賞

  • Recognition of early career investigator

    2019.5  

  • 優秀ポスター賞

    2019.3   カナダ国消化器病学会   優秀ポスター賞

Papers

  • Post-infectious ibs following<i> Clostridioides</i><i> difficile</i> infection; role of microbiota and implications for treatment

    Taghaddos, D; Saqib, Z; Bai, XP; Bercik, P; Collins, SM

    DIGESTIVE AND LIVER DISEASE   56 ( 11 )   1805 - 1809   2024.11   ISSN:1590-8658 eISSN:1878-3562

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  • 今月の主題 食道運動障害の診断と治療 トピックス 食道運動障害の病態評価に対する新たな試み

    水流 大尭, 牟田 和正, 和田 将史, 畑 佳孝, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    胃と腸   59 ( 9 )   1273 - 1278   2024.9   ISSN:05362180 eISSN:18821219

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403203718

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  • 今月の主題 食道運動障害の診断と治療 主題 食道運動障害のX線診断

    畑 佳孝, 水流 大尭, 和田 将史, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    胃と腸   59 ( 9 )   1219 - 1228   2024.9   ISSN:05362180 eISSN:18821219

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403203711

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  • 特集 今この研究が面白い! 第6章 消化管 [便秘]腸内細菌と腸管運動機能

    白 暁鵬, 田中 義将, 伊原 栄吉

    内科   134 ( 3 )   603 - 606   2024.9   ISSN:00221961 eISSN:24329452

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    Publisher:南江堂  

    DOI: 10.15106/j_naika134_603

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  • Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury. International journal

    Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

    Journal of molecular medicine (Berlin, Germany)   102 ( 9 )   1175 - 1186   2024.9   ISSN:0946-2716 eISSN:1432-1440

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    EP4 prostanoid receptor (EP4R) contributes to the intestinal epithelial Cl- secretion, and inhibition of prostaglandin E (PGE) production by non-steroidal anti-inflammatory drugs (NSAIDs) plays a central role in NSAID-induced enteropathy. Although M3 muscarinic acetylcholine receptor (M3R) also contributes to the intestinal epithelial Cl- secretion, it remains unclear whether M3R is involved in NSAID-induced enteropathy due to a lack of selective agents. The present study explored how M3R is involved in the regulation of the intestinal epithelial Cl- secretion and its pathophysiological role in NSAID-induced enteropathy. Using the novel highly-selective M3 positive allosteric modulator PAM-369 that we recently developed, we evaluated the role of M3R in the intestinal epithelial secretion ex vivo by measuring the short circuit current (Isc) of intestinal epithelium with a Ussing chamber system and examined whether or not M3R protects against small intestinal injury in indomethacin-treated mice. Both the PGE1 derivative misoprostol and carbachol similarly increased the Isc in a concentration-dependent manner. The Isc increases were abolished either by receptor antagonists (an EP4R antagonist and a M3R antagonist, respectively) or by removal of extracellular Cl-. PAM-369 enhanced the carbachol-induced Isc by potentiating M3R, which could contribute to enhanced intestinal epithelial secretion. Treatment with PAM-369 ameliorated small intestinal injury in indomethacin-treated mice. Importantly, the M3R expression was significantly up-regulated, and PAM-369 potentiation of M3R was augmented in indomethacin-treated mice compared to untreated mice. These findings show that M3R plays a role in maintaining the intestinal epithelial secretion, which could contribute to protection against indomethacin-induced small intestinal injury. M3R is a promising target for treating or preventing NSAID-induced enteropathy. KEY MESSAGES: PAM-369, the M3 positive allosteric modulator, was used to potentiate M3R. PAM-369 enhanced carbachol-induced Isc in mouse ileum. PAM-369 ameliorated small intestinal injury in indomethacin-treated mice. M3R is a promising target for treating or preventing NSAID-induced enteropathy.

    DOI: 10.1007/s00109-024-02474-0

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  • Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux(タイトル和訳中)

    Wada Masafumi, Minoda Yosuke, Ihara Eikichi, Tsuru Hirotaka, Hata Yoshitaka, Nagatomo Shuzaburo, Esaki Mitsuru, Bai Xiaopeng, Tanaka Yoshimasa, Chinen Takatoshi, Ogino Haruei, Ogawa Yoshihiro

    Digestive Endoscopy   36 ( 8 )   904 - 914   2024.8   ISSN:0915-5635

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    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

  • Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux. International journal

    Masafumi Wada, Yosuke Minoda, Eikichi Ihara, Hirotaka Tsuru, Yoshitaka Hata, Shuzaburo Nagatomo, Mitsuru Esaki, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   36 ( 8 )   904 - 914   2024.8   ISSN:0915-5635 eISSN:1443-1661

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    OBJECTIVES: Reflux hypersensitivity (RH) is a form of refractory gastroesophageal reflux disease in which duodenogastroesophageal reflux (DGER) plays a role. This study aimed to determine the usefulness of an endoscopy system equipped with image-enhanced technology for evaluating DGER and RH. METHODS: The image enhancement mode for detecting bilirubin and calculated values were defined as the Bil mode and Bil value, respectively. First, the visibility of the Bil mode was validated for a bilirubin solution and bile concentrations ranging from 0.01% to 100% (0.002-20 mg/dL). Second, visibility scores of the Bil mode, when applied to the porcine esophagus sprayed with a bilirubin solution, were compared to those of the blue laser imaging (BLI) and white light imaging (WLI) modes. Third, a clinical study was conducted to determine the correlations between esophageal Bil values and the number of nonacid reflux events (NNRE) during multichannel intraluminal impedance-pH monitoring as well as the utility of esophageal Bil values for the differential diagnosis of RH. RESULTS: Bilirubin solution and bile concentrations higher than 1% were visualized in red using the Bil mode. The visibility score was significantly higher with the Bil mode than with the BLI and WLI modes for 1% to 6% bilirubin solutions (P < 0.05). The esophageal Bil value and NNRE were significantly positively correlated (P = 0.031). The area under the receiver operating characteristic curve for the differential diagnosis of RH was 0.817. CONCLUSION: The Bil mode can detect bilirubin with high accuracy and could be used to evaluate DGER in clinical practice.

    DOI: 10.1111/den.14749

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  • アカラシアにおけるTh17免疫反応と関連した食道細菌叢の変化とLC20不全リン酸化の相互作用(The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia)

    Ikeda Hiroko, Ihara Eikichi, Takeya Kosuke, Mukai Koji, Onimaru Manabu, Ouchida Kenoki, Hata Yoshitaka, Bai Xiaopeng, Tanaka Yoshimasa, Sasaki Taisuke, Saito Fumiyo, Eto Masumi, Nakayama Jiro, Oda Yoshinao, Nakamura Masafumi, Inoue Haruhiro, Ogawa Yoshihiro

    Journal of Gastroenterology   59 ( 5 )   361 - 375   2024.5   ISSN:0944-1174

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    Language:English   Publisher:シュプリンガー・ジャパン(株)  

    食道平滑筋収縮の変化および関連する炎症性反応について検討することによりアカラシアの病態を明らかにし、アカラシアの進展における食道細菌叢の意義を評価した。経口的内視鏡的筋層切開術を施行したII型アカラシア症例から得た食道粘膜および下部食道括約筋(LES)標本を解析した。患者由来の食道調整培養液をマウス食道に投与し、食道内環境がアカラシアと関連するか否かについて検討した。安静時および刺激時における対照群のLESでは、20-kDaミオシン軽鎖(LC20)の約30%がリン酸化されていた。アカラシア症例では状況に関わらずLC20のリン酸化は10%未満であった。アカラシアにおける低リン酸化は、ミオシンリン酸化阻害蛋白質CPI-17の発現低下と関連していた。IL-17A、IL-17F、IL-22、IL-23Aを含む関連サイトカインは、アカラシアでは発現が増加していた。食道細菌叢のα-Diversity指数、およびActinomycesおよびDialisterを含む数種類の細菌の割合がアカラシアで増加していた。ActinomycesレベルはIL-23Aレベルと正の相関が認められ、DialisterレベルはIL-17A、IL-17F、IL-22レベルと正の相関が認められた。マウスにおいて、食道IL-17F値は調整培地の経口投与後に増加した。

  • The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia.

    Hiroko Ikeda, Eikichi Ihara, Kosuke Takeya, Koji Mukai, Manabu Onimaru, Kenoki Ouchida, Yoshitaka Hata, Xiaopeng Bai, Yoshimasa Tanaka, Taisuke Sasaki, Fumiyo Saito, Masumi Eto, Jiro Nakayama, Yoshinao Oda, Masafumi Nakamura, Haruhiro Inoue, Yoshihiro Ogawa

    Journal of gastroenterology   59 ( 5 )   361 - 375   2024.5   ISSN:0944-1174 eISSN:1435-5922

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    BACKGROUND: Achalasia is an esophageal motility disorder with an unknown etiology. We aimed to determine the pathogenesis of achalasia by studying alterations in esophageal smooth muscle contraction and the associated inflammatory response, and evaluate the role of esophageal microbiota in achalasia development. METHODS: We analyzed esophageal mucosa and lower esophageal sphincter (LES) samples, obtained from patients with type II achalasia who underwent peroral endoscopic myotomy. Esophageal conditioned media obtained from patients were transferred into the mouse esophagus to determine whether the esophageal intraluminal environment is associated with achalasia. RESULTS: Approximately 30% of 20-kDa myosin light chains (LC20) was phosphorylated in LES from the control group under resting and stimulated conditions, whereas less than 10% of LC20 phosphorylation was detected in achalasia under all conditions. The hypophosphorylation of LC20 in achalasia was associated with the downregulation of the myosin phosphatase-inhibitor protein CPI-17. Th17-related cytokines, including IL-17A, IL-17F, IL-22, and IL-23A, were significantly upregulated in achalasia. α-Diversity index of esophageal microbiota and the proportion of several microbes, including Actinomyces and Dialister, increased in achalasia. Actinomyces levels positively correlated with IL-23A levels, whereas Dialister levels were positively associated with IL-17A, IL-17F, and IL-22 levels. Esophageal IL-17F levels increased in mice after oral administration of the conditioned media. CONCLUSIONS: In LES of patients with achalasia, hypophosphorylation of LC20, a possible cause of impaired contractility, was associated with CPI-17 downregulation and an increased Th17-related immune response. The esophageal intraluminal environment, represented by the esophageal microbiota, could be associated with the development and exacerbation of achalasia.

    DOI: 10.1007/s00535-024-02088-w

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  • 当院における高齢者ボノプラザン抵抗性胃食道逆流症の病態の特徴

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 蓑田 洋介, 江崎 充, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本高齢消化器病学会誌   26 ( 2 )   19 - 24   2024.3   ISSN:1881-0837

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    Language:Japanese   Publisher:(NPO)日本高齢消化器病学会  

    胃食道逆流症(GERD)は病的な酸逆流によって惹起される病態であるが、難治性GERDでは食道知覚過敏や食道運動異常症(EMDs)を考慮した病態評価が必要である。今回、高齢者ボノプラザン(P-CAB)抵抗性GERDの特徴を明らかにするため、75歳以上の高齢者20例と非高齢者51例の食道生理機能検査の結果を比較検討した。高解像度食道内圧検査では非高齢者の41%は正常であったが、高齢者では正常例は認めなかった。食道内多チャンネルインピーダンス・pHモニタリング検査では、非高齢者ではNERD、逆流過敏性食道、機能性胸焼けの3疾患を認めたが、高齢者では逆流過敏性食道は認めなかった。高齢者P-CAB抵抗性GERDでは、EMDsが目立ち食道知覚過敏の影響は小さい可能性がある。(著者抄録)

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  • 当院における高齢者ボノプラザン抵抗性胃食道逆流症の病態の特徴

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 蓑田 洋介, 江崎 充, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本高齢消化器病学会誌   26 ( 2 )   19 - 24   2024.3   ISSN:1881-0837

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    胃食道逆流症(GERD)は病的な酸逆流によって惹起される病態であるが、難治性GERDでは食道知覚過敏や食道運動異常症(EMDs)を考慮した病態評価が必要である。今回、高齢者ボノプラザン(P-CAB)抵抗性GERDの特徴を明らかにするため、75歳以上の高齢者20例と非高齢者51例の食道生理機能検査の結果を比較検討した。高解像度食道内圧検査では非高齢者の41%は正常であったが、高齢者では正常例は認めなかった。食道内多チャンネルインピーダンス・pHモニタリング検査では、非高齢者ではNERD、逆流過敏性食道、機能性胸焼けの3疾患を認めたが、高齢者では逆流過敏性食道は認めなかった。高齢者P-CAB抵抗性GERDでは、EMDsが目立ち食道知覚過敏の影響は小さい可能性がある。(著者抄録)

  • Vasoactive Intestinal Polypeptide Plays a Key Role in the Microbial-Neuroimmune Control of Intestinal Motility. International journal

    Xiaopeng Bai, Giada De Palma, Elisa Boschetti, Yuichiro Nishiharo, Jun Lu, Chiko Shimbori, Anna Costanzini, Zarwa Saqib, Narjis Kraimi, Sacha Sidani, Siegfried Hapfelmeier, Andrew J Macpherson, Elena F Verdu, Roberto De Giorgio, Stephen M Collins, Premysl Bercik

    Cellular and molecular gastroenterology and hepatology   17 ( 3 )   383 - 398   2024   ISSN:2352-345X

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    BACKGROUND & AIMS: Although chronic diarrhea and constipation are common, the treatment is symptomatic because their pathophysiology is poorly understood. Accumulating evidence suggests that the microbiota modulates gut function, but the underlying mechanisms are unknown. We therefore investigated the pathways by which microbiota modulates gastrointestinal motility in different sections of the alimentary tract. METHODS: Gastric emptying, intestinal transit, muscle contractility, acetylcholine release, gene expression, and vasoactive intestinal polypeptide (VIP) immunoreactivity were assessed in wild-type and Myd88-/-Trif-/- mice in germ-free, gnotobiotic, and specific pathogen-free conditions. Effects of transient colonization and antimicrobials as well as immune cell blockade were investigated. VIP levels were assessed in human full-thickness biopsies by Western blot. RESULTS: Germ-free mice had similar gastric emptying but slower intestinal transit compared with specific pathogen-free mice or mice monocolonized with Lactobacillus rhamnosus or Escherichia coli, the latter having stronger effects. Although muscle contractility was unaffected, its neural control was modulated by microbiota by up-regulating jejunal VIP, which co-localized with and controlled cholinergic nerve function. This process was responsive to changes in the microbial composition and load and mediated through toll-like receptor signaling, with enteric glia cells playing a key role. Jejunal VIP was lower in patients with chronic intestinal pseudo-obstruction compared with control subjects. CONCLUSIONS: Microbial control of gastrointestinal motility is both region- and bacteria-specific; it reacts to environmental changes and is mediated by innate immunity-neural system interactions. By regulating cholinergic nerves, small intestinal VIP plays a key role in this process, thus providing a new therapeutic target for patients with motility disorders.

    DOI: 10.1016/j.jcmgh.2023.11.012

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  • Micromagnetic simulation of microwave-assisted magnetization switching and signal recording characteristics for exchange-coupled composite media with layer anisotropy structure

    Tanaka, T; Kurihara, K; Ya, X; Bai, X; Kanai, Y

    JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS   587   2023.12   ISSN:0304-8853 eISSN:1873-4766

  • 「高齢者に多いGERDと便秘症の病態・診断・治療(性差も含めて)」 当院における高齢者の難治性胃食道逆流症の特徴とボノプラザンが与える影響

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本高齢消化器病学会誌   26 ( 1 )   49 - 49   2023.7   ISSN:1881-0837

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  • IMPEDANCE MEASUREMENT IMPROVES DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND GUIDED FINE-NEEDLE BIOPSY FOR SUBEPITHELIAL LESIONS

    Minoda, Y; Esaki, M; Bai, XP; Ihara, E

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB804 - AB804   2023.6   ISSN:0016-5107 eISSN:1097-6779

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  • IMPEDANCE MEASUREMENT IMPROVES DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND GUIDED FINE-NEEDLE BIOPSY FOR SUBEPITHELIAL LESIONS

    Minoda, Y; Esaki, M; Bai, XP; Ihara, E

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB899 - AB900   2023.6   ISSN:0016-5107 eISSN:1097-6779

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  • 特集 GERDを極める [各論 病態と診断] 非びらん性胃食道逆流症の病態と鑑別診断

    伊原 栄吉, 水流 大尭, 和田 将史, 畑 佳孝, 白 暁鵬, 田中 義将, 蓑田 洋介, 江崎 充, 荻野 治栄

    消化器内視鏡   35 ( 5 )   607 - 614   2023.5   ISSN:09153217

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    Publisher:東京医学社  

    DOI: 10.24479/endo.0000000731

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  • 【GERDを極める】病態と診断 非びらん性胃食道逆流症の病態と鑑別診断

    伊原 栄吉, 水流 大尭, 和田 将史, 畑 佳孝, 白 暁鵬, 田中 義将, 蓑田 洋介, 江崎 充, 荻野 治栄

    消化器内視鏡   35 ( 5 )   607 - 614   2023.5   ISSN:0915-3217 ISBN:9784885636738

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  • Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound guided fine-needle biopsy. International journal

    Yosuke Minoda, Mitsuru Esaki, Eikichi Ihara, Shuzaburo Nagatomo, Kei Nishioka, Nao Fujimori, Haruei Ogino, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Qingjiang Hu, Mitsuhiko Ota, Shinya Umekita, Hidetaka Yamamoto, Yoshihiro Ogawa

    Gastrointestinal endoscopy   97 ( 5 )   977 - 984   2023.5   ISSN:0016-5107 eISSN:1097-6779

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    INTRODUCTION: Endoscopic ultrasound guided fine-needle aspiration/biopsy (EUS-FNA/B) is the gold standard for diagnosing subepithelial lesions (SELs); however, its diagnostic ability for SELs <20 mm is low. We developed a new diagnostic method to differentiate between gastrointestinal stromal tumor (GIST) and non-GIST by measuring high-frequency impedance (H-impedance) using an EUS-FNB needle. METHODS: The H-impedance of gastric epithelial neoplasms from 16 cases were measured using a conventional impedance probe to confirm whether H-impedance is clinically useful for assessing cell density (Study 1). The H-impedance values of exposed SELs from 25 cases using the conventional probe (Study 2) and non-exposed SELs from 20 cases using the EUS-FNB needle probe (Study 3) were measured to determine the diagnostic ability of H-impedance for differentiating GISTs from non-GISTs. RESULTS: H-impedance significantly positively correlated with cell density (P=0.030) (Study 1). The H-impedance of GIST (99.5) measured using conventional probe was significantly higher than those of the muscular layer (82.4) and leiomyoma (89.2) (P<0.01) (Study 2). The H-impedance of GIST measured using the EUS-FNB needle was also significantly higher than that of leiomyoma (GIST: 80.2 vs. leiomyoma: 71.8, P=0.015). The diagnostic yield of the impedance method for differentiating GISTs from non-GISTs had 94.4% accuracy, 88.9% sensitivity, 100% specificity, and 0.95 area under the curve. Diagnostic ability was not affected by lesion size (P=0.86) (Study 3). CONCLUSION: Auxiliary differential diagnosis between gastric GISTs and non-GISTs by the H-impedance measurement during EUS-FNB could be a good option especially when the lesion is smaller than 20 mm.

    DOI: 10.1016/j.gie.2022.11.022

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  • Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility. International journal

    Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

    Digestive diseases and sciences   68 ( 2 )   439 - 450   2023.2   ISSN:0163-2116 eISSN:1573-2568

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    BACKGROUND: The specific role of the M3 muscarinic acetylcholine receptor in gastrointestinal motility under physiological conditions is unclear, due to a lack of subtype-selective compounds. AIMS: The objective of this study was to determine the region-specific role of the M3 receptor in gastrointestinal motility. METHODS: We developed a novel positive allosteric modulator (PAM) for the M3 receptor, PAM-369. The effects of PAM-369 on the carbachol-induced contractile response of porcine esophageal smooth muscle and mouse colonic smooth muscle (ex vivo) and on the transit in mouse small intestine and rat colon (in vivo) were examined. RESULTS: PAM-369 selectively potentiated the M3 receptor under the stimulation of its orthosteric ligands without agonistic or antagonistic activity. Half-maximal effective concentrations of PAM activity for human, mouse, and rat M3 receptors were 0.253, 0.345, and 0.127 μM, respectively. PAM-369 enhanced carbachol-induced contraction in porcine esophageal smooth muscle and mouse colonic smooth muscle without causing any contractile responses by itself. The oral administration of 30 mg/kg PAM-369 increased the small intestinal transit in both normal motility and loperamide-induced intestinal dysmotility mice but had no effects on the colonic transit, although the M3 receptor mRNA expression is higher in the colon than in the small intestine. CONCLUSIONS: This study provided the first direct evidence that the M3 receptor has different region-specific roles in the motility function between the small intestine and colon in physiological and pathophysiological contexts. Selective PAMs designed for targeted subtypes of muscarinic receptors are useful for elucidating the subtype-specific function.

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  • Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy. International journal

    Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Surgical endoscopy   37 ( 1 )   101 - 108   2023.1   ISSN:0930-2794 eISSN:1432-2218

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    BACKGROUND: Mucosal incision-assisted biopsy (MIAB) is a valuable alternative to endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNAB) for sampling gastric subepithelial lesions (SELs). This study aimed to evaluate the potential risk of dissemination and impact on postoperative prognosis associated with MIAB, which has not yet been investigated. METHODS: Study 1: A prospective observational study was conducted to examine the presence or absence and growth rate of tumor cells in gastric juice before and after the procedure in patients with SELs who underwent MIAB (n = 25) or EUS-FNAB (n = 22) between September 2018 and August 2021. Study 2: A retrospective study was conducted to examine the impact of MIAB on postoperative prognosis in 107 patients with gastrointestinal stromal tumors diagnosed using MIAB (n = 39) or EUS-FNAB (n = 68) who underwent surgery between January 2001 and July 2020. RESULTS: In study 1, although no tumor cells were observed in gastric juice in MIAB before the procedure, they were observed in 64% of patients after obtaining samples (P < 0.001). In contrast, no tumor cells were observed in the gastric juice in EUS-FNAB before and after the procedure. In study 2, there was no significant difference in 5-year disease-free survival between MIAB (100%) and EUS-FNAB (97.1%) (P = 0.27). CONCLUSION: MIAB is safe, with little impact on postoperative prognosis, although the procedure releases some tumor cells after damaging the SEL's pseudocapsule.

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  • GERDの診断・病態・治療の新展開 ビリルビン検出能する新規内視鏡システムによる逆流過敏性食道の病態評価

    和田 将史, 蓑田 洋介, 水流 大尭, 畑 佳孝, 江崎 充, 長友 周三郎, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   7 ( Suppl. )   143 - 143   2023.1   ISSN:2433-3840 eISSN:2435-8967

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  • Innovative endoscopic submucosal dissection for early gastric neoplasm using intralesional traction and snaring techniques. International journal

    Yoshihisa Shoguchi, Mitsuru Esaki, Yosuke Minoda, Xiaopeng Bai, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   54 ( S 02 )   E865 - E866   2022.12   ISSN:0013-726X eISSN:1438-8812

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  • Application of intralesional traction assistance with traction wire to endoscopic submucosal dissection for colorectal neoplasms. International journal

    Takayuki Nasu, Mitsuru Esaki, Yoshihisa Shoguchi, Xiaopeng Bai, Yosuke Minoda, Haruei Ogino, Eikichi Ihara

    Endoscopy   54 ( S 02 )   E784 - E785   2022.12   ISSN:0013-726X eISSN:1438-8812

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  • 蠕動波出現と食道胃接合部上膨隆所見を用いた食道運動障害性疾患スクリーニングの食道造影改善(Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning)

    Hata Yoshitaka, Ihara Eikichi, Wada Masafumi, Tsuru Hirotaka, Muta Kazumasa, Minoda Yosuke, Bai Xiaopeng, Esaki Mitsuru, Tanaka Yoshimasa, Chinen Takatoshi, Ogino Haruei, Sakamoto Ryuichi, Ogawa Yoshihiro

    Journal of Gastroenterology   57 ( 11 )   838 - 847   2022.11   ISSN:0944-1174

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    食道運動障害性疾患(EMD)を診断するための新たな2所見を用いたバリウム食道造影検査(BE)によるスクリーニングを評価した。2013年1月から2020年10月にEMDが疑われ高解像度マノメトリー検査(HRM)とBEの両方が施行された244例を対象とした。EMDの診断はシカゴ分類第3.0版を用いてHRM所見に基づいて行った。BEは硫酸バリウムを用いて食道連続撮影を行った。従来からのBE所見(ニボー、数珠状/コルク栓抜き様所見、蠕動の消失/減弱)に加え、新規2所見(蠕動波出現、胃食道接合部上膨隆所見)を診断に用いた。新規2所見と従来の3所見を診断に用いた場合のBEスクリーニングの感度は79.4%、特異度は88%であった(受信者動作特性曲線下領域(AUC)=0.837)。新規2所見を診断に用いない場合には、感度は63.9%、特異度は96%(AUC=0.800)であった。アカラシアはニボー形成と特に関連性が強かった(88.7%)。収縮の消失は蠕動の消失/減弱と強く関連していた(85.7%)。遠位食道痙攣と数珠状/コルク栓抜き様所見との間(60%)およびアカラシアと蠕動波出現(59.7%)との間には比較的高い関連性が認められた。個々のBE所見の観察者内再現性、観察者間一致率はそれぞれ84.4%、75%であった。蠕動波出現は積算弛緩圧(IRP)高値および遠位潜時短縮と関連していた。食道胃接合部上膨隆はIRP高値と関連していた。新規の2所見を追加したBEスクリーニングによるEMDの診断は一般診療において有用である可能性が示された。

  • Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning.

    Yoshitaka Hata, Eikichi Ihara, Masafumi Wada, Hirotaka Tsuru, Kazumasa Muta, Yosuke Minoda, Xiaopeng Bai, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Ryuichi Sakamoto, Yoshihiro Ogawa

    Journal of gastroenterology   57 ( 11 )   838 - 847   2022.11   ISSN:0944-1174 eISSN:1435-5922

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    BACKGROUND: High-resolution manometry (HRM) is the gold standard for diagnosing esophageal motility disorders (EMDs); however, it requires specialized equipment. The development of more accessible screening examinations is expected. We evaluated the utility of barium esophagography (BE) screening using two novel findings to diagnose EMDs. METHODS: Between January 2013 and October 2020, 244 patients with suspected EMDs who underwent both HRM and BE were analyzed. The EMD diagnosis was based on HRM findings using Chicago Classification version 3.0. BE was performed using sequential esophagography with barium sulfate. Three conventional BE findings (air-fluid level, rosary-bead/corkscrew appearance, and absent/weak peristalsis) and two novel BE findings (wave appearance and supra-junctional ballooning) were used for diagnosis. RESULTS: The sensitivity and specificity of BE screening using the two novel findings and conventional findings to diagnose EMDs were 79.4% and 88%, respectively [area under the receiver-operating characteristic curve (AUC) = 0.837]. Without these novel findings, they were 63.9% and 96%, respectively (AUC = 0.800), respectively. Achalasia was highly correlated with the air-fluid level (88.7%). Absent contractility was highly correlated with absent/weak peristalsis (85.7%). Relatively high correlations were observed between distal esophageal spasm and rosary-bead/corkscrew appearance (60%), and between achalasia and wave appearance (59.7%). The intra-observer reproducibility and inter-observer agreement for individual BE findings were 84.4% and 75%, respectively. Wave appearance was associated with higher integrated relaxation pressure (IRP) and shorter distal latency. Supra-junctional ballooning was associated with higher IRP. CONCLUSIONS: BE screening using two additional novel findings to diagnose EMDs could be useful in general practice.

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  • Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. International journal

    Yosuke Minoda, Eikichi Ihara, Nao Fujimori, Shuzaburo Nagatomo, Mitsuru Esaki, Yoshitaka Hata, Xiaopeng Bai, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Qingjiang Hu, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Scientific reports   12 ( 1 )   16640 - 16640   2022.10   ISSN:2045-2322

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    Gastrointestinal stromal tumors (GISTs) are common subepithelial lesions (SELs) and require treatment considering their malignant potential. We recently developed an endoscopic ultrasound-based artificial intelligence (EUS-AI) system to differentiate GISTs from non-GISTs in gastric SELs, which were used to train the system. We assessed whether the EUS-AI system designed for diagnosing gastric GISTs could be applied to non-gastric GISTs. Between January 2015 and January 2021, 52 patients with non-gastric SELs (esophagus, n = 15; duodenum, n = 26; colon, n = 11) were enrolled. The ability of EUS-AI to differentiate GISTs from non-GISTs in non-gastric SELs was examined. The accuracy, sensitivity, and specificity of EUS-AI for discriminating GISTs from non-GISTs in non-gastric SELs were 94.4%, 100%, and 86.1%, respectively, with an area under the curve of 0.98 based on the cutoff value set using the Youden index. In the subanalysis, the accuracy, sensitivity, and specificity of EUS-AI were highest in the esophagus (100%, 100%, 100%; duodenum, 96.2%, 100%, 0%; colon, 90.9%, 100%, 0%); the cutoff values were determined using the Youden index or the value determined using stomach cases. The diagnostic accuracy of EUS-AI increased as lesion size increased, regardless of lesion location. EUS-AI based on gastric SELs had good diagnostic ability for non-gastric GISTs.

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  • Traction-assisted hybrid endoscopic submucosal dissection for small rectal neuroendocrine tumors

    Nasu, T; Esaki, M; Shoguchi, Y; Bai, XP; Minoda, Y; Ogino, H; Ihara, E

    ENDOSCOPY   54 ( 10 )   E550 - E551   2022.10   ISSN:0013-726X eISSN:1438-8812

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    DOI: 10.1055/a-1662-4965

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  • Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice. International journal

    Giada De Palma, Chiko Shimbori, David E Reed, Yang Yu, Virginia Rabbia, Jun Lu, Nestor Jimenez-Vargas, Jessica Sessenwein, Cintya Lopez-Lopez, Marc Pigrau, Josue Jaramillo-Polanco, Yong Zhang, Lauren Baerg, Ahmad Manzar, Julien Pujo, Xiaopeng Bai, Maria Ines Pinto-Sanchez, Alberto Caminero, Karen Madsen, Michael G Surette, Michael Beyak, Alan E Lomax, Elena F Verdu, Stephen M Collins, Stephen J Vanner, Premysl Bercik

    Science translational medicine   14 ( 655 )   eabj1895   2022.7

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    The gut microbiota has been implicated in chronic pain disorders, including irritable bowel syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed that decreasing intake of fermentable carbohydrates improved abdominal pain in patients with IBS, and this was accompanied by changes in the gut microbiota and decreased urinary histamine concentrations. Here, we used germ-free mice colonized with fecal microbiota from patients with IBS to investigate the role of gut bacteria and the neuroactive mediator histamine in visceral hypersensitivity. Germ-free mice colonized with the fecal microbiota of patients with IBS who had high but not low urinary histamine developed visceral hyperalgesia and mast cell activation. When these mice were fed a diet with reduced fermentable carbohydrates, the animals showed a decrease in visceral hypersensitivity and mast cell accumulation in the colon. We observed that the fecal microbiota from patients with IBS with high but not low urinary histamine produced large amounts of histamine in vitro. We identified Klebsiella aerogenes, carrying a histidine decarboxylase gene variant, as a major producer of this histamine. This bacterial strain was highly abundant in the fecal microbiota of three independent cohorts of patients with IBS compared with healthy individuals. Pharmacological blockade of the histamine 4 receptor in vivo inhibited visceral hypersensitivity and decreased mast cell accumulation in the colon of germ-free mice colonized with the high histamine-producing IBS fecal microbiota. These results suggest that therapeutic strategies directed against bacterial histamine could help treat visceral hyperalgesia in a subset of patients with IBS with chronic abdominal pain.

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  • 胃食道流出路閉塞に対するアコチアミドの治療有効性 前向き縦断的観察研究(The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study)

    Ihara Eikichi, Ogino Haruei, Muta Kazumasa, Hamada Shohei, Wada Masafumi, Hata Yoshitaka, Ikeda Hiroko, Bai Xiaopeng, Minoda Yosuke, Esaki Mitsuru, Tanaka Yoshimasa, Chinen Takatoshi, Ogawa Yoshihiro

    Esophagus   19 ( 2 )   332 - 342   2022.4   ISSN:1612-9059

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    消化管運動改善薬であるアコチアミドの、食道胃接合部流出路閉塞(EGJOO)に対する有効性を検討した。2014年10月から2020年3月までの間に、EGJOO 25例に対してアコチアミド(100mg、1日3回)を4週間投与した。治療開始直前と治療後に高解像度マノメトリー検査(HRM)を施行した。主要評価項目である積算弛緩厚(IRP)は、治療前(19.4、17.1-27.4mmHg)と比較して治療後(14.6、12.1-22.0mmHg)で有意に低かった。下部食道括約筋(LES)調節指数も、治療後(32.7,21.0-40.0mmHg)が治療前(39.3,31.2-50.2mmHg)と比較して有意に低かった。アコチアミドは、EGJOO25症例中13例(52%)でIRPを正常化(<15mmHg)し、IRPは25例のEGJOO症例中20例(80%)でIRPを減少させた。副次評価項目であるFSSGスコアには、治療前と治療後で有意な変化は認められなかった。アコチアミドが奏効した13例を対象としたサブグループ解析では、アコチアミドにより嚥下障害が有意に改善していた。アコチアミドは、基礎LES圧およびLES調節反応の両方を低下させることによりIRP値を減少させることで、EGJOO患者において治療効果を示すことが明らかになった。

  • The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study

    Ihara, E; Ogino, H; Muta, K; Hamada, S; Wada, M; Hata, Y; Ikeda, H; Bai, X; Minoda, Y; Esaki, M; Tanaka, Y; Chinen, T; Ogawa, Y

    ESOPHAGUS   19 ( 2 )   332 - 342   2022.4   ISSN:1612-9059 eISSN:1612-9067

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    Objectives: We have found that an altered lower esophageal sphincter (LES) accommodation response is an underlying cause of esophagogastric junction outflow obstruction (EGJOO). The objective of this study was to examine the treatment effect of acotiamide, a prokinetic agent which improves impaired gastric accommodation in functional dyspepsia, in patients with EGJOO. Methods: A prospective observational longitudinal study was conducted between October 2014 and March 2020. Acotiamide (100 mg, 3 times a day) was administered to 25 patients with EGJOO for 4 weeks. High-resolution manometry (HRM) was performed just before and after 4 weeks of treatment. Results: As the primary outcome, the extent of integrated relaxation pressure (IRP) after treatment (14.6, 12.1–22.0 mmHg) was significantly lower than that before treatment (19.4, 17.1–27.4 mmHg). The extent of LES accommodation index after treatment (32.7, 21.0–40.0 mmHg) was also significantly lower than that before treatment (39.3, 31.2–50.2 mmHg). Acotiamide normalized the IRP (< 15 mmHg) in 13 of 25 patients with EGJOO (52%), and the IRP was decreased in 20 of 25 patients with EGJOO (80%). As the secondary outcome, the total FSSG score in 25 patients with EGJOO before and after acotiamide treatment showed no significant difference. In a sub-analysis of 13 patients in whom EGJOO was normalized by acotiamide, however, dysphagia was reported to be significantly improved by acotiamide. Conclusions: Acotiamide has a treatment effect on patients with EGJOO via a reduction in the IRP level through the lowering of both the basal LES pressure and LES accommodation response. Dysphagia is a key symptom to be evaluated and treated in patients with EGJOO.

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  • Ex vivoブタモデルを用いた、大きな胃病変に対するProKnife注入内視鏡的粘膜下層剥離術と従来法の内視鏡的粘膜下層剥離術の比較 無作為化対照試験(Comparisons of outcomes between ProKnife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial)

    Esaki Mitsuru, Ihara Eikichi, Esaki Misato, Nishioka Kei, Kimura Yusuke, Hata Yoshitaka, Tsuru Hirotaka, Wada Masafumi, Minoda Yosuke, Bai Xiaopeng, Shoguchi Yoshihisa, Nasu Takayuki, Nagatomo Shuzaburo, Muta Kazumasa, Ogino Haruei, Ogawa Yoshihiro

    DEN Open   2 ( 1 )   1 of 8 - 8 of 8   2022.4

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    Ex vivoブタモデルの胃病変70ヵ所に対して、ProKnifeを用いた内視鏡的粘膜下層剥離術(P-ESD)または従来法の内視鏡的粘膜下層剥離術(C-ESD)を無作為に振り分け、12名の内視鏡医が施行した。各群1病変を粘膜肥厚のため除外したことにより、検討対象は各群34病変となった。処置時間はP-ESD群が36.3(28.4-46.8)分、C-ESD群が46(36.4-64.6)分で、有意にP-ESD群が短かった(P=0.0014)。技術的成功率には差は認められなかった(一括切除率は両群とも100%、完全切除率はP-ESD群94.1%、C-ESD群85.3%、P=0.23)。P-ESD処置中の注入回数は7.5(6-10)回で、C-ESD群の4(3-5)回よりも有意に多かった(P<0.001)が、注入薬液総量はP-ESD群が20(16-26.3)ml、C-ESD群が27.5(20-31.5)mlで、P-ESD群が有意に少なかった(P=0.0019)。多変量解析の結果、ESD未熟練(オッズ比(OR)3.9)、C-ESD法(OR3.8)がESD困難性の独立した予測因子であった。

  • Comparisons of outcomes between ProKnife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Misato Esaki, Kei Nishioka, Yusuke Kimura, Yoshitaka Hata, Hirotaka Tsuru, Masafumi Wada, Yosuke Minoda, Xiaopeng Bai, Yoshihisa Shoguchi, Takayuki Nasu, Shuzaburo Nagatomo, Kazumasa Muta, Haruei Ogino, Yoshihiro Ogawa

    DEN open   2 ( 1 )   e91   2022.4   ISSN:2692-4609

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    Objective: To compare treatment outcomes between injection endoscopic submucosal dissection using ProKnife (P-ESD) and conventional ESD (C-ESD) for gastric lesions. Methods: In this randomized controlled trial, we compared treatment outcomes of P-ESD and C-ESD for simulated gastric lesions ≥3 cm in resected porcine stomachs. Predictive factors associated with ESD difficulties were investigated using logistic regression analysis. Results: Seventy lesions were screened; however, two lesions were excluded. A total of 12 endoscopists performed 68 ESDs: 34 P-ESDs and 34 C-ESDs. The ESD procedure time of P-ESD (36.3 [28.4-46.8] min) was significantly shorter than that of C-ESD (46 [36.4-64.6] min; p = 0.0014). The technical success rates did not differ between the P-ESD and C-ESD groups (en bloc resection rate, 100% in both groups; complete resection rate, 94.1% and 85.3%, respectively; p = 0.23). The number of injections during P-ESD (7.5 [6-10] times) was significantly higher than during C-ESD (4 [3-5] times; p < 0.001), but the total volume of injected solution during P-ESD (20 [16-26.3] ml) was significantly smaller than during C-ESD (27.5 [20-31.5] ml; p = 0.0019). In multivariate analysis, less ESD experience (odds ratio [OR], 3.9) and selection of C-ESD as the ESD method (OR, 3.8) were independent predictive factors associated with ESD difficulties. Conclusions: Compared with C-ESD, P-ESD had a shorter procedure time but also allowed for notable technical success and safety.

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  • Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows.

    Bai Xiaopeng

    Scientific reports   2021.4

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    DOI: 10.1038/s41598-021-87052-x

  • Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body.

    Bai Xiaopeng

    European journal of pharmacology   2019.5

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    DOI: 10.1016/j.ejphar.2019.172405

  • Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function.

    Bai Xiaopeng

    Digestion   2018.4

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    DOI: 10.1159/000487708

  • Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger.

    Bai Xiaopeng

    Cellular and molecular gastroenterology and hepatology   2017.11

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    DOI: 10.1016/j.jcmgh.2017.11.004

  • Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body.

    Bai Xiaopeng

    European journal of pharmacology   2017.1

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    DOI: 10.1016/j.ejphar.2017.01.004

  • New Approach to Diagnosis and Treatment of Esophageal Motility Disorders by High-Resolution manometry.

    Bai Xiaopeng

    Fukuoka igaku zasshi = Hukuoka acta medica   2016.7

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  • Clinical characteristics associated with esophageal motility function.

    Bai Xiaopeng

    Journal of gastroenterology and hepatology   2016.6

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    DOI: 10.1111/jgh.13262

  • Effective hemostasis with double-balloon rectal catheter for uncontrolled bleeding during endoscopic mucosal resection of large rectal neoplasms.

    Bai Xiaopeng

    Endoscopy   2013.5

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    DOI: 10.1055/s-0032-1326282

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  • 【今この研究が面白い!】(第6章)消化管 便秘 腸内細菌と腸管運動機能 a role of microbes in gut motility

    白 暁鵬, 田中 義将, 伊原 栄吉

    内科   134 ( 3 )   603 - 606   2024.9   ISSN:0022-1961

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    Language:Japanese   Publisher:(株)南江堂  

    <文献概要>・われわれは慢性便秘症の病態解明と新規治療法の開発を目指し,腸内細菌が腸管運動機能に及ぼす影響とその機序について基礎およびトランスレーショナル研究を行っている.・単一菌種を定着させたノトバイオート動物モデルを用いて,腸内細菌が宿主自然免疫反応を介し,小腸筋間神経叢の血管作動性腸管ペプチド(VIP)神経の発現調節が腸管運動機能の発達・維持に重要な役割を果たすことを解明した.・慢性便秘症患者より採取した糞便を移植して作製したマウスモデルを解析したところ,慢性便秘症患者から採取した腸内細菌が大腸筋間神経叢に炎症性マクロファージを増加させ,Cajal介在細胞(ICC)のネットワーク障害をきたし,大腸運動低下に至る経路を見出した.

  • 【GERDを極める】病態と診断 非びらん性胃食道逆流症の病態と鑑別診断

    伊原 栄吉, 水流 大尭, 和田 将史, 畑 佳孝, 白 暁鵬, 田中 義将, 蓑田 洋介, 江崎 充, 荻野 治栄

    消化器内視鏡   35 ( 5 )   607 - 614   2023.5   ISSN:0915-3217

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    Language:Japanese   Publisher:(株)東京医学社  

Professional Memberships

  • Canadian association of gastroenterology

  • Japan society of smooth muscle research

  • Japan gastroenterological endoscopy society

  • The Japanese society of gastroenterology

  • The Japanese society of internal medicine

Academic Activities

  • 座長 International contribution

    2021.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

    Proceedings of domestic conference Number of peer-reviewed papers:18

  • 座長 International contribution

    2020.2 - 2020.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:18

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

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Research Projects

  • Contribution of gut microbiota to the maturation and maintenance of intestinal motility

    Grant number:22K15969  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • 腸内環境が消化管機能の発達とその維持に果たす機序解明

    2021.5

    九州大学(日本) 

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    Authorship:Coinvestigator(s) 

    腸内環境が消化管機能の発達とその維持に果たす機序を解明する。

  • 腸内細菌が腸管運動機能に及ぼす影響とその機序

    2021 - 2022

    成人病の病因・病態の解明に関する研究助成

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    Authorship:Principal investigator  Grant type:Contract research

Outline of Social Contribution and International Cooperation activities

  • 臨床研究・基礎研究で得られた成果を学会・研究会で発表し、英文誌に投稿することにより社会に発信し貢献します。
    博士研究員として在籍していたカナダMcMaster大学消化器内科研究室と連携し、腸内細菌領域の研究ついて学術交流を行っています。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Gastroenterology

Clinician qualification

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Specialist

    The Japanese Society of Gastroenterology(JSGE)

Year of medical license acquisition

  • 2009