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写真a

ミノダ ヨウスケ
蓑田 洋介
MINODA YOSUKE
所属
九州大学病院 肝臓・膵臓・胆道内科 助教
九州大学病院 光学医療診療部(併任)
九州大学病院 肝臓・膵臓・胆道内科(併任)
医学部 医学科(併任)
職名
助教
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プロフィール
九州大学病院光学診療部にて消化管の研究、診療活動に従事している。研究:人工知能を用いた消化管腫瘍ならびに消化管粘膜下腫瘍の自動診断システムの開発;消化管粘膜下腫瘍にはGISTをはじめとした悪性腫瘍が存在し、早期に診断することで治癒が望める。現在は超音波内視鏡下生検が標準的診断法であるが、人工知能を併用することで特別な技術が無くても診断できる方法を開発している。消化管運動・バリア機能に注目したLeaky gutと胆膵領域の関連を研究している。消化管と胆膵領域は相互に影響を及ぼしていることが知られているが、その病態の解明をすることで、これまで肥満、NAFLD、NASHなどの治療で難渋している症例の解明を目指している。 診療:消化管粘膜下腫瘍に対する診断ならび治療法の開発を積極的に行っている。さらに消化管腫瘍に対する内視鏡治療として粘膜下層剥離術を応用した低侵襲の新しい治療法の開発を行っている。また超音波内視鏡を使用した、胆膵領域の診断や内視鏡的粘膜下層剥離術の技術を応用してネクロゼクトミ―と呼ばれる感染性膵嚢胞に対する治療を積極的に行っている。

学位

  • 博士(九州大学)

研究テーマ・研究キーワード

  • 研究テーマ: 超音波内視鏡

    研究キーワード: 超音波内視鏡

    研究期間: 2024年

  • 研究テーマ: 膵癌

    研究キーワード: 膵癌

    研究期間: 2024年

  • 研究テーマ: 消化管粘膜下腫瘍

    研究キーワード: 消化管粘膜下腫瘍

    研究期間: 2024年

  • 研究テーマ: 消化管粘膜バリア機能

    研究キーワード: 消化管粘膜バリア機能

    研究期間: 2024年

  • 研究テーマ: 機能性ディスペプシア

    研究キーワード: 機能性ディスペプシア

    研究期間: 2024年

  • 研究テーマ: 早期消化管癌

    研究キーワード: 早期消化管癌

    研究期間: 2024年

  • 研究テーマ: 人工知能

    研究キーワード: 人工知能

    研究期間: 2024年

  • 研究テーマ: 消化管腫瘍に対する人工知能併用の内視鏡検査の有用性評価

    研究キーワード: 人工知能

    研究期間: 2023年4月

  • 研究テーマ: 消化管粘膜バリア機能と消化管運動機能異常症の解明

    研究キーワード: 消化管粘膜バリア機能

    研究期間: 2021年4月 - 2025年5月

  • 研究テーマ: 機能性ディスペプシアの病態解明

    研究キーワード: 機能性ディスペプシア

    研究期間: 2019年4月

  • 研究テーマ: 消化管粘膜下腫瘍の内視鏡画像による人工知能を使用した新規診断法

    研究キーワード: 消化管粘膜下腫瘍、人工知能

    研究期間: 2018年5月 - 2023年5月

受賞

  • DEN open Best reviewer

    2024年4月   日本消化器内視鏡学会  

  • Most downloaded author

    2024年3月   日本消化器内視鏡学会  

  • Best presenter award

    2024年1月   GI bioregulation  

  • Best discussant award

    2024年1月   GI bioregulation  

  • Best presenter award

    2024年1月   GI bioregulation  

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  • Best discussant award

    2024年1月   GI bioregulation  

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  • JSGE-UEG Rising Stars

    2023年4月  

  • JSGE-UEG Rising Stars

    2023年4月  

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  • 第34回日本消化器病学会奨励賞

    2021年4月  

  • 第62回 日本消化器病学会大会会長賞

    2020年11月  

▼全件表示

論文

  • Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis 国際誌

    Ogura, K; Ichijima, R; Ikehara, H; Sugita, T; Yamaguchi, D; Nagata, Y; Esaki, M; Minoda, Y; Ono, H; Hotta, K; Kiriyama, S; Sumiyoshi, T; Kanmura, Y

    DEN OPEN   5 ( 1 )   e412   2025年4月   ISSN:2692-4609

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:DEN Open  

    Objectives: To compare the efficacy and safety of sedation with midazolam and remimazolam for colorectal endoscopy. Methods: This single-center, two-arm, post-hoc analysis of the REM-IICTJP01 study investigated the efficacy and safety of remimazolam for gastrointestinal endoscopic sedation. We enrolled 40 and 208 patients who underwent colonoscopy under remimazolam and midazolam sedation, respectively, during the same period. The primary outcome was the time from the end of the colonoscopy until discharge. The secondary outcomes included the time from the end of the colonoscopy until awakening, dosage, and adverse events. Propensity score matching was employed to eliminate the effect of confounding factors. Results: Thirty-seven patients in each group were matched. After propensity matching, the time to awakening after colonoscopy was 28.0 (13.0–37.0) min in the midazolam group and 0 (0–0) min in the remimazolam group; moreover, the time till discharge was 40.0 (35.0–46.5) min in the midazolam group and 0 (0–5.0) min in the remimazolam group, both of which were significantly shorter in the remimazolam group (p < 0.01). The number of additional doses was 0 (0–0) and 2 (1–3) in the midazolam and remimazolam groups, respectively. The total dose was 2.0 (2.0–3.5) and 6.0 (5.0–7.0) mg in the midazolam and remimazolam groups, respectively. Conclusions: Remimazolam yielded significantly faster times to awakening and discharge safely compared to midazolam.

    DOI: 10.1002/deo2.412

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  • Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis(タイトル和訳中)

    Ogura Kanako, Ichijima Ryoji, Ikehara Hisatomo, Sugita Tomomi, Yamaguchi Daisuke, Nagata Yasuhiko, Esaki Mitsuru, Minoda Yosuke, Ono Hiroyuki, Hotta Kinichi, Kiriyama Shinsuke, Sumiyoshi Tetsuya, Kanmura Yuichi

    DEN Open   5 ( 1 )   deo2.412 - deo2.412   2025年4月

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

  • Effective hemostasis with a self-assembling peptide hemostatic gel to manage leaky hemorrhage at the ulcer closure site after gastric endoscopic submucosal dissection 国際誌

    Maruoka, R; Esaki, M; Minoda, Y; Otsuka, Y; Haraguchi, K; Ogino, H; Ihara, E

    ENDOSCOPY   56 ( S 01 )   E323-E324 - E324   2024年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2291-9050

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  • Antral early gastric neoplasm with severe oral scarring successfully treated by endoscopic submucosal dissection using retroflex approach and a novel, thin therapeutic endoscope 国際誌

    Maruoka, R; Esaki, M; Minoda, Y; Tadokoro, M; Haraguchi, K; Ogino, H; Ihara, E

    ENDOSCOPY   56 ( S 01 )   E703 - E705   2024年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2371-0911

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  • Pancreatic duct occlusion after endoscopic ultrasound-guided transmural pancreatic duct drainage: a pitfall and its rescue technique 国際誌

    Gerodias A.R., Ohno A., Komori Y., Minoda Y., Ueda K., Moriyama T., Fujimori N.

    Endoscopy   56 ( S 01 )   E544-E545 - E545   2024年12月   ISSN:0013-726X

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2334-0926

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  • Enhanced visualization of vessels in submucosa by amber red color imaging in colonic endoscopic submucosal dissection 国際誌

    Maruoka, R; Esaki, M; Minoda, Y; Otsuka, Y; Haraguchi, K; Ogino, H; Ihara, E

    ENDOSCOPY   56 ( S 01 )   E601 - E602   2024年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2351-3985

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  • 今月の主題 食道運動障害の診断と治療 主題 食道運動障害のX線診断

    畑 佳孝, 水流 大尭, 和田 将史, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    胃と腸   59 ( 9 )   1219 - 1228   2024年9月   ISSN:05362180 eISSN:18821219

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    出版者・発行元:株式会社医学書院  

    DOI: 10.11477/mf.1403203711

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  • 今月の主題 食道運動障害の診断と治療 トピックス 食道運動障害の病態評価に対する新たな試み

    水流 大尭, 牟田 和正, 和田 将史, 畑 佳孝, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    胃と腸   59 ( 9 )   1273 - 1278   2024年9月   ISSN:05362180 eISSN:18821219

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    出版者・発行元:株式会社医学書院  

    DOI: 10.11477/mf.1403203718

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  • Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux(タイトル和訳中)

    Wada Masafumi, Minoda Yosuke, Ihara Eikichi, Tsuru Hirotaka, Hata Yoshitaka, Nagatomo Shuzaburo, Esaki Mitsuru, Bai Xiaopeng, Tanaka Yoshimasa, Chinen Takatoshi, Ogino Haruei, Ogawa Yoshihiro

    Digestive Endoscopy   36 ( 8 )   904 - 914   2024年8月   ISSN:0915-5635

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

  • Randomized Controlled Trial of Remimazolam Compared with Placebo in Japanese Patients Undergoing Colonoscopy: A Phase III, Investigator-Initiated Trial. 国際誌

    Ichijima R, Ikehara H, Ono H, Hotta K, Yamaguchi D, Esaki M, Minoda Y, Nagata Y, Ogura K, Kiriyama S, Sumiyoshi T, Kanmura Y

    Digestion   1 - 9   2024年7月   ISSN:0012-2823

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: We conducted an investigator-initiated clinical trial in which remimazolam was used to achieve sedation in patients undergoing colonoscopy. METHODS: This multicenter, double-blind, placebo-controlled, phase III investigator-initiated trial included patients who underwent colonoscopy under sedation achieved with remimazolam (initial dose: 3 mg; additional doses: 1 mg) or normal saline (placebo). The primary endpoint was the sedation success rate during colonoscopy, defined as successful sedation (modified observer's alertness/sedation [MOAA/S] score ≤4 prior to colonoscopy), the successful completion of the colonoscopy, and no more than five additional doses of remimazolam per 15 min during the procedure. RESULTS: The sedation success rate was 95.0% (38/40 patients) in the remimazolam group and 0.0% (0/11 patients) in the placebo group (p&lt;0.01). The time from the end of the procedure to awakening was 0.0 (interquartile range: 0.0-0.0) min in both groups. The time from the end of the procedure to ambulation was 5.0 min (interquartile range: 0.0-10.0 min) in the remimazolam group and 0.0 min (interquartile range: 0.0-0.0 min) in the placebo group (p=0.02). No serious adverse events occurred. CONCLUSION: The use of remimazolam to achieve sedation in Japanese patients undergoing colonoscopy was more effective than the use of a placebo. CLINICAL TRIAL REGISTRATION: This study was registered in the Japan Registry of Clinical Trials (registration number: jRCT2031200360).

    DOI: 10.1159/000540527

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  • COMPARISON BETWEEN REMIMAZOLAM AND PLACEBO IN JAPANESE PATIENTS UNDERGOING COLONOSCOPY: A PHASE III, INVESTIGATOR-INITIATED, RANDOMIZED, CONTROLLED TRIAL

    Yamaguchi, D; Ichijima, R; Ikehara, H; Ono, H; Hotta, K; Esaki, M; Minoda, Y; Nagata, Y; Ogura, K; Kiriyama, S; Sumiyoshi, T; Kanmura, Y

    GASTROINTESTINAL ENDOSCOPY   99 ( 6 )   AB613 - AB614   2024年6月   ISSN:0016-5107 eISSN:1097-6779

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  • COMPARISON BETWEEN REMIMAZOLAM AND PLACEBO IN JAPANESE PATIENTS UNDERGOING COLONOSCOPY: A PHASE III, INVESTIGATOR-INITIATED, RANDOMIZED, CONTROLLED TRIAL

    Yamaguchi, D; Ichijima, R; Ikehara, H; Ono, H; Hotta, K; Esaki, M; Minoda, Y; Nagata, Y; Ogura, K; Kiriyama, S; Sumiyoshi, T; Kanmura, Y

    GASTROINTESTINAL ENDOSCOPY   99 ( 6 )   AB523 - AB524   2024年6月   ISSN:0016-5107 eISSN:1097-6779

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  • 当院における高齢者ボノプラザン抵抗性胃食道逆流症の病態の特徴

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 蓑田 洋介, 江崎 充, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本高齢消化器病学会誌   26 ( 2 )   19 - 24   2024年3月   ISSN:1881-0837

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    記述言語:日本語   出版者・発行元:(NPO)日本高齢消化器病学会  

    胃食道逆流症(GERD)は病的な酸逆流によって惹起される病態であるが、難治性GERDでは食道知覚過敏や食道運動異常症(EMDs)を考慮した病態評価が必要である。今回、高齢者ボノプラザン(P-CAB)抵抗性GERDの特徴を明らかにするため、75歳以上の高齢者20例と非高齢者51例の食道生理機能検査の結果を比較検討した。高解像度食道内圧検査では非高齢者の41%は正常であったが、高齢者では正常例は認めなかった。食道内多チャンネルインピーダンス・pHモニタリング検査では、非高齢者ではNERD、逆流過敏性食道、機能性胸焼けの3疾患を認めたが、高齢者では逆流過敏性食道は認めなかった。高齢者P-CAB抵抗性GERDでは、EMDsが目立ち食道知覚過敏の影響は小さい可能性がある。(著者抄録)

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  • 当院における高齢者ボノプラザン抵抗性胃食道逆流症の病態の特徴

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 蓑田 洋介, 江崎 充, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本高齢消化器病学会誌   26 ( 2 )   19 - 24   2024年3月   ISSN:1881-0837

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    記述言語:日本語   出版者・発行元:(NPO)日本高齢消化器病学会  

    胃食道逆流症(GERD)は病的な酸逆流によって惹起される病態であるが、難治性GERDでは食道知覚過敏や食道運動異常症(EMDs)を考慮した病態評価が必要である。今回、高齢者ボノプラザン(P-CAB)抵抗性GERDの特徴を明らかにするため、75歳以上の高齢者20例と非高齢者51例の食道生理機能検査の結果を比較検討した。高解像度食道内圧検査では非高齢者の41%は正常であったが、高齢者では正常例は認めなかった。食道内多チャンネルインピーダンス・pHモニタリング検査では、非高齢者ではNERD、逆流過敏性食道、機能性胸焼けの3疾患を認めたが、高齢者では逆流過敏性食道は認めなかった。高齢者P-CAB抵抗性GERDでは、EMDsが目立ち食道知覚過敏の影響は小さい可能性がある。(著者抄録)

  • Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing upper gastrointestinal endoscopy: Phase III investigator-initiated clinical trial 国際誌

    Ichijima, R; Ikehara, H; Yamaguchi, D; Nagata, Y; Ogura, K; Esaki, M; Minoda, Y; Ono, H; Maeda, Y; Kiriyama, S; Sumiyoshi, T; Kanmura, Y; Gotoda, T

    DIGESTIVE ENDOSCOPY   2024年2月   ISSN:0915-5635 eISSN:1443-1661

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Digestive Endoscopy  

    Objectives: To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in a multicenter, randomized, double-blind, investigator-initiated phase III controlled trial. Methods: We included 48 Japanese patients undergoing upper gastrointestinal endoscopy. For the procedure, an initial remimazolam dose of 3 mg and additional doses of 1 mg were administered, as determined in the phase II clinical study. The primary study end-point was the successful sedation rate during gastrointestinal endoscopy, determined as a Modified Observer's Assessment of Alertness/Sedation score ≤4 before the start of endoscopy, the completion of gastrointestinal endoscopy, and two or fewer additional doses per 6 min. Results: The successful endoscopy sedation rates were 91.9% and 9.1% in the remimazolam and placebo groups, respectively (P < 0.01). The time from the end of endoscopy to arousal was 0.0 (0.0–0.0) min for both groups. The number of additional doses required to achieve sedation was lower in the remimazolam group than that in the placebo group (P < 0.01). Conclusions: Remimazolam demonstrated a significantly higher sedation effect during upper gastrointestinal endoscopy in Japanese patients with safe and fast recovery compared with placebo.

    DOI: 10.1111/den.14758

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  • 特集 糖尿病性腎症研究の最前線 糖尿病性腎症の発症機序 肥満・糖尿病における腸内細菌叢の変化

    蓑田 洋介, 松田 やよい, 小川 佳宏

    腎と透析   96 ( 2 )   165 - 169   2024年2月   ISSN:03852156

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    出版者・発行元:東京医学社  

    DOI: 10.24479/kd.0000001188

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  • Three-point traction method for endoscopic submucosal dissection using clip-with-thread and clip-with-silicon bands for large early gastric neoplasms 国際誌

    Maruoka, R; Esaki, M; Minoda, Y; Tokunaga, N; Haraguchi, K; Ihara, E; Ogawa, Y

    ENDOSCOPY INTERNATIONAL OPEN   12 ( 1 )   E57-E58 - E58   2024年1月   ISSN:2364-3722 eISSN:2196-9736

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-2219-8130

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  • Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for multicenter randomized controlled trial (Spray-G trial) 国際誌

    Maehara, K; Esaki, M; Sumida, Y; Yamaguchi, D; Nishioka, K; Homma, H; Inada, T; Shiotsuki, K; Fukuda, SI; Akiho, H; Nomura, T; Mizuta, Y; Ishida, S; Fujimoto, S; Kimura, S; Tanaka, Y; Hata, K; Shiga, N; Iwasa, T; Kimura, Y; Nakamura, N; Suzuki, Y; Minoda, Y; Hata, Y; Ogino, H; Tagawa, K; Ihara, E; Ogawa, Y

    TRIALS   25 ( 1 )   53 - 53   2024年1月   eISSN:1745-6215

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Trials  

    BACKGROUND: Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGN). Controlling intraoperative bleeding is crucial for ensuring safe and reliable procedures. ESD using the spray coagulation mode (SCM-ESD) has been developed to control bleeding more effectively than ESD using the conventional forced coagulation mode (FCM-ESD). This study aims to compare the hemostatic efficacies of SCM-ESD and FCM-ESD. METHODS: This multicenter, prospective, parallel, randomized, open-label superiority trial will be conducted in five Japanese institutions. Patients with a preoperative diagnosis of intramucosal EGC will be randomized to undergo either SCM-ESD or FCM-ESD. The primary outcome measure is the completion of ESD with an electrosurgical knife alone, without the use of hemostatic forceps. Secondary outcomes include the number and duration of hemostasis using hemostatic forceps, procedure time, curability, and safety. A total of 130 patients will be enrolled in this study. DISCUSSION: This trial will provide evidence on the hemostatic efficacy of SCM-ESD compared with FCM-ESD in patients with intramucosal EGN, potentially improving the safety and reliability of ESD procedures. TRIAL REGISTRATION: The trial has been registered at the University Hospital Medical Information Network Clinical Trials Registration (UMIN-CTR) as UMIN000040518. The reception number is R000054009.

    DOI: 10.1186/s13063-023-07852-6

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  • 胃上皮性腫瘍に対するSpray-ESDの効果 多施設共同無作為化比較試験 Spray-G Trial

    稲田 泰亮, 江崎 充, 隅田 頼信, 本間 仁, 前原 浩亮, 塩月 一生, 秋穂 裕唯, 山口 太輔, 中村 典資, 蓑田 洋介, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   8 ( Suppl. )   280 - 280   2024年1月   ISSN:2433-3840 eISSN:2435-8967

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • 胃ESDにおける滑車式2点固定トラクション法

    近藤 悠樹, 武内 翼, 江崎 充, 蓑田 洋介, 畑 佳孝, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   8 ( Suppl. )   317 - 317   2024年1月   ISSN:2433-3840 eISSN:2435-8967

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  • 大腸腫瘍に対する従来型ESDおよび牽引ESDの無作為化比較試験(CONNECT-C試験)

    市島 諒二, 池原 久朝, 隅田 頼信, 稲田 泰亮, 根本 大樹, 中島 勇貴, 皆川 武慶, 住吉 徹哉, 居軒 和也, 吉田 直久, 井上 健, 福澤 誠克, 蓑田 洋介, 堤 康志郎, 江崎 充, 後藤田 卓志

    Gastroenterological Endoscopy   66 ( 1 )   78 - 88   2024年1月   ISSN:0387-1207

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

    【目的】消化管早期癌に対する治療として内視鏡的粘膜下層剥離術(ESD)は広く浸透している.しかし大腸ESDは未だ難しい手技である.トラクションを使用した大腸ESDが有用であると報告があるが,いずれも症例数が少なく単施設での研究であり有用性を示すには不十分なエビデンスしかなかった.われわれは,大腸ESDにおけるトラクション法の有用性と安全性を検討する多施設前向き研究を行った.【方法】われわれは,前向き,多施設共同,無作為化割り付け,2群間比較試験を日本における10施設で行った.従来法ESD群(C-ESD),トラクションESD群(T-ESD)を1:1に割り付けた.主要評価項目は,内視鏡治療時間とした.【結果】2020年4月から2021年8月までの間にC-ESD群128名,T-ESD群123名を研究対象とした.C-ESDとT-ESDにおける治療時間の中央値は,それぞれ61(40-100)分,53(40-76)分(p=0.18)で両群に統計学的な有意差は認めなかった.副次解析で行った病変径≧30mmにおけるC-ESDとT-ESDにおける治療時間はそれぞれ,89(57-80)分,69(50-104)分(p=0.05),非熟練医における治療時間は81(62-120)分,64(52-109)分(p=0.07)であった.【結語】大腸ESDにおいてトラクション法は治療時間の短縮には寄与しなかった.しかしながら,腫瘍径が大きい場合や非熟練医が行う場合は有用である可能性がある.(著者抄録)

  • 大腸ESD後の創部縫縮に対する新規治療法 Traction-band-assisted endoscopic closure(T-BEC)の多施設前向き試験について

    前原 浩亮, 江崎 充, 隅田 頼信, 稲田 泰亮, 本間 仁, 塩月 一生, 秋穂 裕唯, 蓑田 洋介, 中村 典資, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   8 ( Suppl. )   287 - 287   2024年1月   ISSN:2433-3840 eISSN:2435-8967

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • 大腸腫瘍に対する従来型ESDおよび牽引ESDの無作為化比較試験(CONNECT-C試験)

    市島 諒二, 池原 久朝, 隅田 頼信, 稲田 泰亮, 根本 大樹, 中島 勇貴, 皆川 武慶, 住吉 徹哉, 居軒 和也, 吉田 直久, 井上 健, 福澤 誠克, 蓑田 洋介, 堤康 志郎, 江崎 充, 後藤田 卓志

    日本消化器内視鏡学会雑誌   66 ( 1 )   78 - 88   2024年   ISSN:03871207 eISSN:18845738

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    記述言語:日本語   出版者・発行元:一般社団法人 日本消化器内視鏡学会  

    <p>【目的】消化管早期癌に対する治療として内視鏡的粘膜下層剝離術(ESD)は広く浸透している.しかし大腸ESDは未だ難しい手技である.トラクションを使用した大腸ESDが有用であると報告があるが,いずれも症例数が少なく単施設での研究であり有用性を示すには不十分なエビデンスしかなかった.われわれは,大腸ESDにおけるトラクション法の有用性と安全性を検討する多施設前向き研究を行った.</p><p>【方法】われわれは,前向き,多施設共同,無作為化割り付け,2群間比較試験を日本における10施設で行った.従来法ESD群(C-ESD),トラクションESD群(T-ESD)を1:1に割り付けた.主要評価項目は,内視鏡治療時間とした.</p><p>【結果】2020年4月から2021年8月までの間にC-ESD群128名,T-ESD群123名を研究対象とした.C-ESDとT-ESDにおける治療時間の中央値は,それぞれ61(40-100)分,53(40-76)分(p=0.18)で両群に統計学的な有意差は認めなかった.副次解析で行った病変径≧30mmにおけるC-ESDとT-ESDにおける治療時間はそれぞれ,89(57-80)分,69(50-104)分(p=0.05),非熟練医における治療時間は81(62-120)分,64(52-109)分(p=0.07)であった.</p><p>【結語】大腸ESDにおいてトラクション法は治療時間の短縮には寄与しなかった.しかしながら,腫瘍径が大きい場合や非熟練医が行う場合は有用である可能性がある.</p>

    DOI: 10.11280/gee.66.78

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  • Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux 国際誌

    Wada, M; Minoda, Y; Ihara, E; Tsuru, H; Hata, Y; Nagatomo, S; Esaki, M; Bai, XP; Tanaka, Y; Chinen, T; Ogino, H; Ogawa, Y

    DIGESTIVE ENDOSCOPY   36 ( 8 )   904 - 914   2023年12月   ISSN:0915-5635 eISSN:1443-1661

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Digestive Endoscopy  

    OBJECTIVES: Reflux hypersensitivity (RH) is a form of refractory gastroesophageal reflux disease in which duodenogastroesophageal reflux (DGER) plays a role. This study aimed to determine the usefulness of an endoscopy system equipped with image-enhanced technology for evaluating DGER and RH. METHODS: The image enhancement mode for detecting bilirubin and calculated values were defined as the Bil mode and Bil value, respectively. First, the visibility of the Bil mode was validated for a bilirubin solution and bile concentrations ranging from 0.01% to 100% (0.002-20 mg/dL). Second, visibility scores of the Bil mode, when applied to the porcine esophagus sprayed with a bilirubin solution, were compared to those of the blue laser imaging (BLI) and white light imaging (WLI) modes. Third, a clinical study was conducted to determine the correlations between esophageal Bil values and the number of nonacid reflux events (NNRE) during multichannel intraluminal impedance-pH monitoring as well as the utility of esophageal Bil values for the differential diagnosis of RH. RESULTS: Bilirubin solution and bile concentrations higher than 1% were visualized in red using the Bil mode. The visibility score was significantly higher with the Bil mode than with the BLI and WLI modes for 1% to 6% bilirubin solutions (P < 0.05). The esophageal Bil value and NNRE were significantly positively correlated (P = 0.031). The area under the receiver operating characteristic curve for the differential diagnosis of RH was 0.817. CONCLUSION: The Bil mode can detect bilirubin with high accuracy and could be used to evaluate DGER in clinical practice.

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  • Two-step traction-assisted endoscopic submucosal dissection for a gastric neoplasm using a clip with a traction band and thread 国際誌

    Nishioka, K; Esaki, M; Iwasa, T; Minoda, Y; Shiga, N; Ogino, H; Ihara, E

    ENDOSCOPY   55 ( S 01 )   E1041-E1042 - E1042   2023年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2155-7172

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  • Two-point fixed pulley-traction method in endoscopic submucosal dissection for early gastric neoplasm 国際誌

    Takeuchi, T; Esaki, M; Minoda, Y; Hata, Y; Ogino, H; Ihara, E; Ogawa, Y

    ENDOSCOPY   55 ( S 01 )   E1087-E1088 - E1088   2023年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2173-8010

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  • Double-scope technique to recover from hand-suturing trouble in the duodenum 国際誌

    Sato, LY; Hata, Y; Esaki, M; Ihara, E; Tajiri, S; Moriyama, T; Minoda, Y

    ENDOSCOPY   55 ( S 01 )   E1193-E1194 - E1194   2023年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2199-3398

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  • Underwater precutting endoscopic mucosal resection using a multifunctional snare for a large colonic laterally spreading tumor 国際誌

    Shiotsuki, K; Sumida, Y; Esaki, M; Minoda, Y; Fukuda, S; Ihara, E; Akiho, H

    ENDOSCOPY   55 ( S 01 )   E702-E703 - E703   2023年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2072-3383

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  • Rare complications related to lumen-apposing metal stent placement, successfully treated by endoscopic hand-suturing device. 国際誌

    Minoda, Y; Fujimori, N; Esaki, M; Nagatomo, S; Komori, Y; Ueda, K; Ihara, E

    ENDOSCOPY   55 ( S 01 )   E692-E693 - E693   2023年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-2072-5740

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  • Clinical significance of dual-energy dual-layer CT parameters in differentiating small-sized gastrointestinal stromal tumors from leiomyomas

    Tsurumaru, D; Nishimuta, Y; Kai, S; Oki, E; Minoda, Y; Ishigami, K

    JAPANESE JOURNAL OF RADIOLOGY   41 ( 12 )   1389 - 1396   2023年12月   ISSN:1867-1071 eISSN:1867-108X

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Journal of Radiology  

    Purpose: Small gastrointestinal stromal tumors (GISTs) can generally have nonspecific CT findings similar to those with benign submucosal tumors of the stomach. The purpose of this study was to explore the potential dual-layer dual-energy CT (dlDECT) parameters to differentiate small-sized (≤ 4 cm) GISTs from leiomyomas of the stomach. Materials and methods: This retrospective study included 26 SMTs ≤ 4 cm in diameter with pathological confirmation of either GIST (n = 17) or leiomyoma (n = 9) from May 2018 to January 2022. All patients received contrast-enhanced CT. The normalized iodine concentration (NIC) and spectral slope (λ HU) were compared between GIST and leiomyoma. Receiver-operating characteristic (ROC) curves were plotted and the areas under the curve (AUCs) were calculated to estimate the diagnostic performance of these markers for differentiating GISTs from leiomyomas. Results: NIC was significantly higher in GIST than in leiomyoma in the portal (P = 0.0019) and delayed phases (P = 0.0011). λ HU was significantly higher in GIST than in leiomyoma in the portal (P = 0.0006) and delayed phases (P = 0.0009). AUC of the ROC curves using NIC to differentiate between GIST and leiomyoma were 0.875 and 0.895 in the portal and delayed phase; using λ HU, they were 0.918 and 0.902 in the portal and delayed phase. Conclusion: dlDECT parameters including NIC and λ HU show promise as indicators for differentiating small-sized GISTs from leiomyomas.

    DOI: 10.1007/s11604-023-01473-4

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  • 小型の消化管間質腫瘍と平滑筋腫の鑑別におけるdual-energy dual-layer CTパラメータの臨床的意義(Clinical significance of dual-energy dual-layer CT parameters in differentiating small-sized gastrointestinal stromal tumors from leiomyomas)

    Tsurumaru Daisuke, Nishimuta Yusuke, Kai Satohiro, Oki Eiji, Minoda Yosuke, Ishigami Kousei

    Japanese Journal of Radiology   41 ( 12 )   1389 - 1396   2023年12月   ISSN:1867-1071

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    記述言語:英語   出版者・発行元:(公社)日本医学放射線学会  

    胃の小型の消化管間質腫瘍(GIST)と平滑筋腫の鑑別におけるdual-energy dual-layer CT(dlDECT)パラメータの有用性について後方視的に検討した。2018年5月~2022年1月に病理学的に確認された直径4cm以下のGIST患者17人(男性11人、女性6人、40~81歳)と平滑筋腫患者9人(男性5人、女性4人、27~72歳)を対象とした。GISTと平滑筋腫におけるdlDECTパラメータの標準化ヨウ素濃度及びスペクトル傾斜を比較した。その結果、dlDECTパラメータは小型のGSTと平滑筋腫の鑑別に有用な指標であることが示された。

  • 膵嚢胞性疾患の診断と治療を考える! 膵嚢胞性病変に対するEUSガイド下組織採取の有用性

    末永 顕彦, 大野 彰久, 蓑田 洋介, 植田 圭二郎, 藤森 尚

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   122回・116回   112 - 112   2023年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-九州支部  

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  • 全天球カメラとヘッドマウントディスプレイを用いたリアルタイム内視鏡ライブ配信の評価

    富松 俊太, 久田 由紀子, 上田 真太郎, 工藤 孔梨子, 蓑田 洋介, 森山 智彦

    日本遠隔医療学会雑誌   19 ( 2 )   75 - 78   2023年10月

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    記述言語:日本語  

    遠隔会議システムを用いた従来の内視鏡ライブ配信では、視聴者の視点がカメラの画角内に制限されているという課題がある。本研究では内視鏡室を自由な視点で見ることができる全天球カメラによるリアルタイム配信と、VRヘッドセットによる受信の品質を評価した。遠隔会議の画面共有で配信する内視鏡映像と、全天球カメラで配信する内視鏡室の映像について、配信のパフォーマンスの記録および視聴者へのアンケートを実施した。結果、内視鏡映像は解像度1536×864、5~21fpsを推移し、内視鏡室からの映像は解像度1920×960、0~15fpsという結果となった。アンケート結果ではどちらの映像においても精細さ、スムーズさとも9割以上が肯定的に評価した。全天球カメラによる内視鏡室の配信は非常に高評価であったものの、教育効果を高めるため機材の配置や異なる映像品質での配信評価など追加で検討を行っていく必要がある。(著者抄録)

  • 全天球カメラとヘッドマウントディスプレイを用いたリアルタイム内視鏡ライブ配信の評価

    富松 俊太, 久田 由紀子, 上田 真太郎, 工藤 孔梨子, 蓑田 洋介, 森山 智彦

    日本遠隔医療学会雑誌   19 ( 2 )   75 - 78   2023年10月   ISSN:1880-800X

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    記述言語:日本語   出版者・発行元:(一社)日本遠隔医療学会  

    遠隔会議システムを用いた従来の内視鏡ライブ配信では、視聴者の視点がカメラの画角内に制限されているという課題がある。本研究では内視鏡室を自由な視点で見ることができる全天球カメラによるリアルタイム配信と、VRヘッドセットによる受信の品質を評価した。遠隔会議の画面共有で配信する内視鏡映像と、全天球カメラで配信する内視鏡室の映像について、配信のパフォーマンスの記録および視聴者へのアンケートを実施した。結果、内視鏡映像は解像度1536×864、5~21fpsを推移し、内視鏡室からの映像は解像度1920×960、0~15fpsという結果となった。アンケート結果ではどちらの映像においても精細さ、スムーズさとも9割以上が肯定的に評価した。全天球カメラによる内視鏡室の配信は非常に高評価であったものの、教育効果を高めるため機材の配置や異なる映像品質での配信評価など追加で検討を行っていく必要がある。(著者抄録)

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  • 全天球カメラとヘッドマウントディスプレイを用いたリアルタイム内視鏡ライブ配信の評価

    富松 俊太, 久田 由紀子, 上田 真太郎, 工藤 孔梨子, 蓑田 洋介, 森山 智彦

    日本遠隔医療学会雑誌   19 ( 2 )   75 - 78   2023年10月   ISSN:1880-800X

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    記述言語:日本語   出版者・発行元:(一社)日本遠隔医療学会  

    遠隔会議システムを用いた従来の内視鏡ライブ配信では、視聴者の視点がカメラの画角内に制限されているという課題がある。本研究では内視鏡室を自由な視点で見ることができる全天球カメラによるリアルタイム配信と、VRヘッドセットによる受信の品質を評価した。遠隔会議の画面共有で配信する内視鏡映像と、全天球カメラで配信する内視鏡室の映像について、配信のパフォーマンスの記録および視聴者へのアンケートを実施した。結果、内視鏡映像は解像度1536×864、5~21fpsを推移し、内視鏡室からの映像は解像度1920×960、0~15fpsという結果となった。アンケート結果ではどちらの映像においても精細さ、スムーズさとも9割以上が肯定的に評価した。全天球カメラによる内視鏡室の配信は非常に高評価であったものの、教育効果を高めるため機材の配置や異なる映像品質での配信評価など追加で検討を行っていく必要がある。(著者抄録)

  • Hybrid Endoscopic Submucosal Dissection for Early Gastric Neoplasms: An Ideal Technique? Reply

    Esaki, M; Minoda, Y; Ihara, E

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   21 ( 9 )   2437 - 2438   2023年8月   ISSN:1542-3565 eISSN:1542-7714

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    記述言語:英語   出版者・発行元:Clinical Gastroenterology and Hepatology  

    DOI: 10.1016/j.cgh.2022.12.004

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  • 「高齢者に多いGERDと便秘症の病態・診断・治療(性差も含めて)」 当院における高齢者の難治性胃食道逆流症の特徴とボノプラザンが与える影響

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本高齢消化器病学会誌   26 ( 1 )   49 - 49   2023年7月

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    記述言語:日本語  

  • 「高齢者に多いGERDと便秘症の病態・診断・治療(性差も含めて)」 当院における高齢者の難治性胃食道逆流症の特徴とボノプラザンが与える影響

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本高齢消化器病学会誌   26 ( 1 )   49 - 49   2023年7月   ISSN:1881-0837

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    記述言語:日本語   出版者・発行元:(NPO)日本高齢消化器病学会  

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  • HEMOSTATIC ABILITY OF SPRAY COAGULATION MODE IN ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC NEOPLASMS

    Maehara, K; Esaki, M; Sumida, Y; Shiotsuki, K; Minoda, Y; Fukuda, SI; Ihara, E; Akiho, H

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB242 - AB243   2023年6月   ISSN:0016-5107 eISSN:1097-6779

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  • コールドスネアポリペクトミーにより切除した大腸高度異形成と癌の管理 多施設探索的研究(Management of colorectal high-grade dysplasia or cancer resected by cold snare polypectomy: a multicenter exploratory study)

    Inoki Kazuya, Takamaru Hiroyuki, Furuhashi Hiroto, Kishida Yoshihiro, Shimodate Yuichi, Sumida Yorinobu, Hosotani Kazuya, Ueyama Hiroya, Furumoto Yohei, Hashimoto Shinichi, Takeuchi Yoji, Ichijima Ryoji, Yoshizawa Yashiro, Suzuki Takuto, Minoda Yosuke, Mizukami Kazuhiro, Matsumura Tomoaki, Kasai Toyotaka, Yamamura Takeshi, Ohnita Ken, Hara Ken, Esaki Mitsuru, Katagiri Atsushi, Ishikawa Hideki, Gotoda Takuji

    Journal of Gastroenterology   58 ( 6 )   554 - 564   2023年6月   ISSN:0944-1174

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    記述言語:英語   出版者・発行元:シュプリンガー・ジャパン(株)  

    高度異形成(HFD)または癌に対するコールドスネアポリペクトミー(CSP)を行った患者について、CSP後の大腸のHGDと癌の予後を分析した。2014~2020年に大腸のHGDまたは癌に対してCSPを行い、少なくとも1回は大腸内視鏡検査を行った患者に関する全国多施設探索的研究を後ろ向きに行った。22施設の患者155名(20歳以上、男性110名、女性45名)の156例について、HGDと癌のデータからCSP傷跡の検出率、局所再発率(LRR)、局所再発の危険因子および経過観察を解析した。最初の内視鏡検査で73例(46.8%)にCSPでの傷跡が検出された。そのうち10例(13.7%)で残存腫瘍が検出された。

  • TRACTION-ASSISTED ENDOSCOPIC ULTRASOUND-GUIDED FINE-NEEDLE BIOPSY USING THE CLIP-WITH-THREAD METHOD FOR SMALL GASTRIC SUBEPITHELIAL LESIONS: A RANDOMIZED CONTROL TRIAL

    Suzuki, Y; Minoda, Y; Ihara, E; Fujimori, N; Nagatomo, S; Ueda, K; Esaki, M; Ogino, H; Ogawa, Y

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB805 - AB806   2023年6月   ISSN:0016-5107 eISSN:1097-6779

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  • PREDICTORS FOR DIFFICULTIES OR FAILURES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL NEOPLASMS: A MULTICENTER STUDY

    Esaki, M; Ichijima, R; Sumida, Y; Inada, T; Nemoto, D; Nakajima, Y; Minagawa, T; Sumiyoshi, T; Inoki, K; Yoshida, N; Inoue, K; Fukuzawa, M; Minoda, Y; Tsutsumi, K; Maehara, K; Ihara, E; Akiho, H; Gotoda, T

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB420 - AB420   2023年6月   ISSN:0016-5107 eISSN:1097-6779

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  • PREDICTORS FOR DIFFICULTIES OR FAILURES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL NEOPLASMS: A MULTICENTER STUDY

    Esaki, M; Ichijima, R; Sumida, Y; Inada, T; Nemoto, D; Nakajima, Y; Minagawa, T; Sumiyoshi, T; Inoki, K; Yoshida, N; Inoue, K; Fukuzawa, M; Minoda, Y; Tsutsumi, K; Maehara, K; Ihara, E; Akiho, H; Gotoda, T

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB506 - AB506   2023年6月   ISSN:0016-5107 eISSN:1097-6779

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  • IMPEDANCE MEASUREMENT IMPROVES DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND GUIDED FINE-NEEDLE BIOPSY FOR SUBEPITHELIAL LESIONS

    Minoda, Y; Esaki, M; Bai, XP; Ihara, E

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB899 - AB900   2023年6月   ISSN:0016-5107 eISSN:1097-6779

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  • IMPEDANCE MEASUREMENT IMPROVES DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND GUIDED FINE-NEEDLE BIOPSY FOR SUBEPITHELIAL LESIONS

    Minoda, Y; Esaki, M; Bai, XP; Ihara, E

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB804 - AB804   2023年6月   ISSN:0016-5107 eISSN:1097-6779

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  • HEMOSTATIC ABILITY OF SPRAY COAGULATION MODE IN ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC NEOPLASMS

    Maehara, K; Esaki, M; Sumida, Y; Shiotsuki, K; Minoda, Y; Fukuda, S; Ihara, E; Akiho, H

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB140 - AB141   2023年6月   ISSN:0016-5107 eISSN:1097-6779

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  • 特集 GERDを極める [各論 病態と診断] 非びらん性胃食道逆流症の病態と鑑別診断

    伊原 栄吉, 水流 大尭, 和田 将史, 畑 佳孝, 白 暁鵬, 田中 義将, 蓑田 洋介, 江崎 充, 荻野 治栄

    消化器内視鏡   35 ( 5 )   607 - 614   2023年5月   ISSN:09153217

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    出版者・発行元:東京医学社  

    DOI: 10.24479/endo.0000000731

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  • 【GERDを極める】病態と診断 非びらん性胃食道逆流症の病態と鑑別診断

    伊原 栄吉, 水流 大尭, 和田 将史, 畑 佳孝, 白 暁鵬, 田中 義将, 蓑田 洋介, 江崎 充, 荻野 治栄

    消化器内視鏡   35 ( 5 )   607 - 614   2023年5月

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    記述言語:日本語  

  • Triangle-traction-assisted endoscopic submucosal dissection with multiple loop traction device for colorectal neoplasms

    Inada, T; Esaki, M; Minoda, Y

    DIGESTIVE ENDOSCOPY   35 ( 4 )   E74 - E75   2023年5月   ISSN:0915-5635 eISSN:1443-1661

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    記述言語:英語   出版者・発行元:Digestive Endoscopy  

    DOI: 10.1111/den.14546

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  • 膵癌・胆道癌診療の実情と早期診断への挑戦 初回のEUSガイド下組織採取で診断困難な膵腫瘤に対するストラテジー

    大野 彰久, 藤森 尚, 長友 周三郎, 蓑田 洋介, 植田 圭二郎

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   121回・115回   91 - 91   2023年5月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-九州支部  

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  • 【GERDを極める】病態と診断 非びらん性胃食道逆流症の病態と鑑別診断

    伊原 栄吉, 水流 大尭, 和田 将史, 畑 佳孝, 白 暁鵬, 田中 義将, 蓑田 洋介, 江崎 充, 荻野 治栄

    消化器内視鏡   35 ( 5 )   607 - 614   2023年5月   ISSN:0915-3217 ISBN:9784885636738

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • Management of colorectal high-grade dysplasia or cancer resected by cold snare polypectomy: a multicenter exploratory study

    Inoki, K; Takamaru, H; Furuhashi, H; Kishida, Y; Shimodate, Y; Sumida, Y; Hosotani, K; Ueyama, H; Furumoto, Y; Hashimoto, S; Takeuchi, Y; Ichijima, R; Yoshizawa, Y; Suzuki, T; Minoda, Y; Mizukami, K; Matsumura, T; Kasai, T; Yamamura, T; Ohnita, K; Hara, K; Esaki, M; Katagiri, A; Ishikawa, H; Gotoda, T

    JOURNAL OF GASTROENTEROLOGY   58 ( 6 )   554 - 564   2023年3月   ISSN:0944-1174 eISSN:1435-5922

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Gastroenterology  

    BACKGROUND: The clinical course and surveillance strategy for patients who undergo cold snare polypectomy (CSP) for high-grade dysplasia (HGD) or cancer is unclear. We investigated the management of colorectal HGDs and cancers following CSP. METHODS: This Japanese nationwide multicenter exploratory study was retrospectively conducted on patients who had undergone CSP for colorectal HGDs or cancers and follow-up colonoscopy at least once from 2014 to 2020. We investigated the detection rate of CSP scars, local recurrence rate (LRR), risk factors for local recurrence, and follow-up strategy. This study was registered with the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000043670). RESULTS: We included 155 patients with 156 lesions. CSP scars were identified in 22 (31.4%), 41 (54.7%), and 10 (90.9%) patients with curative, borderline, and non-curative resection, respectively. Among them, residual tumors were observed in one (4.5%), six (14.6%), and three (30.0%) cases, respectively. The total LRR was 13.7% (95% confidence interval: 6.8-23.8). R1 resection cases (either horizontal or vertical margins positive for tumors) were associated with local recurrence (p = 0.031). Salvage endoscopic and surgical resections were performed on 21 and 10 patients, respectively. Among them, the proportion of endoscopically suspected residual tumors was significantly higher (p < 0.001) in the residual tumor-positive group (100%) than in the residual tumor-negative group (28.6%). CONCLUSIONS: LRR after CSP for HGDs or cancers was 13.7% based on scar-identified cases. Salvage endoscopic or surgical resection should be performed according to the curability of the lesion and endoscopic findings during colonoscopic surveillance.

    DOI: 10.1007/s00535-023-01980-1

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  • 消化管粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断の有用性

    蓑田 洋介, 畑 佳孝, 江崎 充, 長友 周三郎, 荻野 治栄, 伊原 栄吉, 小川 佳宏

    日本内科学会雑誌   112 ( 臨増 )   168 - 168   2023年2月

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    記述言語:日本語  

  • 消化管粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断の有用性

    蓑田 洋介, 畑 佳孝, 江崎 充, 長友 周三郎, 荻野 治栄, 伊原 栄吉, 小川 佳宏

    日本内科学会雑誌   112 ( 臨増 )   168 - 168   2023年2月   ISSN:0021-5384 eISSN:1883-2083

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • Non-atrophic gastric mucosa is an independently associated factor for superficial non-ampullary duodenal epithelial tumors: a multicenter, matched, case-control study 国際誌

    Kawasaki, A; Tsuji, K; Uedo, N; Kanesaka, T; Miyamoto, H; Gushima, R; Minoda, Y; Ihara, E; Amano, R; Yao, K; Naito, Y; Aoyagi, H; Iwasaki, T; Uchita, K; Arima, H; Doyama, H

    CLINICAL ENDOSCOPY   56 ( 1 )   75 - 82   2023年1月   ISSN:2234-2400 eISSN:2234-2443

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIMS: The etiology of superficial non-ampullary duodenal epithelial tumors (SNADETs) remains unclear. Recent studies have reported conflicting associations between duodenal tumor development and Helicobacter pylori (H. pylori) infection or endoscopic gastric mucosal atrophy. As such, the present study aimed to clarify the relationship between SNADETs and H. pylori infection and/or endoscopic gastric mucosal atrophy. METHODS: This retrospective case-control study reviewed data from 177 consecutive patients with SNADETs who underwent endoscopic or surgical resection at seven institutions in Japan over a three-year period. The prevalence of endoscopic gastric mucosal atrophy and the status of H. pylori infection were compared in 531 sex- and age-matched controls selected from screening endoscopies at two of the seven participating institutions. RESULTS: For H. pylori infection, 85 of 177 (48.0%) patients exhibited SNADETs and 112 of 531 (21.1%) control patients were non-infected (p<0.001). Non-atrophic mucosa (C0 to C1) was observed in 96 of 177 (54.2%) patients with SNADETs and 112 of 531 (21.1%) control patients (p<0.001). Conditional logistic regression analysis revealed that non-atrophic gastric mucosa was an independent risk factor for SNADETs (odds ratio, 5.10; 95% confidence interval, 2.44-8.40; p<0.001). CONCLUSIONS: Non-atrophic gastric mucosa, regardless of H. pylori infection status, was a factor independently associated with SNADETs.

    DOI: 10.5946/ce.2022.059

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  • GERDの診断・病態・治療の新展開 ビリルビン検出能する新規内視鏡システムによる逆流過敏性食道の病態評価

    和田 将史, 蓑田 洋介, 水流 大尭, 畑 佳孝, 江崎 充, 長友 周三郎, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   7 ( Suppl. )   143 - 143   2023年1月

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    記述言語:日本語  

  • 良性食道疾患(GERD、運動異常症、裂孔ヘルニア)に対する内視鏡・外科治療 おにぎり食道造影検査を用いた非アカラシア性食道運動障害に対するPOEMの治療戦略の提案 胃側の筋層切開についての検討

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 長友 周三郎, 蓑田 洋介, 江崎 充, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   7 ( Suppl. )   186 - 186   2023年1月

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    記述言語:日本語  

  • GERDの診断・病態・治療の新展開 ビリルビン検出能する新規内視鏡システムによる逆流過敏性食道の病態評価

    和田 将史, 蓑田 洋介, 水流 大尭, 畑 佳孝, 江崎 充, 長友 周三郎, 白 暁鵬, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   7 ( Suppl. )   143 - 143   2023年1月   ISSN:2433-3840 eISSN:2435-8967

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • 良性食道疾患(GERD、運動異常症、裂孔ヘルニア)に対する内視鏡・外科治療 おにぎり食道造影検査を用いた非アカラシア性食道運動障害に対するPOEMの治療戦略の提案 胃側の筋層切開についての検討

    水流 大尭, 和田 将史, 畑 佳孝, 牟田 和正, 長友 周三郎, 蓑田 洋介, 江崎 充, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   7 ( Suppl. )   186 - 186   2023年1月   ISSN:2433-3840 eISSN:2435-8967

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • 早期大腸腫瘍に対する従来型および牽引法による内視鏡的粘膜下層剥離術を比較する無作為化試験(CONNECT-C研究)(Randomized controlled trial comparing conventional and traction endoscopic submucosal dissection for early colon tumor(CONNECT-C trial))

    Ichijima Ryoji, Ikehara Hisatomo, Sumida Yorinobu, Inada Taisuke, Nemoto Daiki, Nakajima Yuki, Minagawa Takeyoshi, Sumiyoshi Tetsuya, Inoki Kazuya, Yoshida Naohisa, Inoue Ken, Fukuzawa Masakatsu, Minoda Yosuke, Tsutsumi Koshiro, Esaki Mitsuru, Gotoda Takuji

    Digestive Endoscopy   35 ( 1 )   86 - 93   2023年1月   ISSN:0915-5635

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

    牽引法による内視鏡的粘膜下層剥離術(ESD)の有効性と安全性を多施設無作為化試験により検証した。日本の10施設において前向き、多施設、無作為化2群調整試験を行った。従来型ESD(C-ESD)および牽引法によるESD(T-ESD)群に患者を1対1で割り付けた。主要観察項目はESD処置時間とした。2020年4月から2021年8月までに登録されたC-ESD群は128例、T-ESD群は123例であった。C-ESDおよびT-ESDの処置時間の中央値はそれぞれ61(40~100)分、53(40~76)分で(P=0.18)、群間に有意差は認められなかった。サブグループ解析では、病変径≧30mmの場合の処置時間は、C-ESD群が89(57~80)分、T-ESD群が69(50~104)分(P=0.05)、非熟練医が処置したC-ESD群では81(62~120)分、T-ESD群が64(52~109)分であった(P=0.07)。牽引法によりESD処置時間の有意な短縮は認められなかったが、腫瘍径が大きい場合、また非熟練医が処置を行う場合には有用である可能性が示唆された。

  • 特集 胆膵EUSのトラブルシューティング [治療的EUS 各論] Peripancreatic/pancreatic fluid collection(PFC)ドレナージ ステントが迷入してしまった

    藤森 尚, 大野 彰久, 植田 圭二郎, 蓑田 洋介, 小川 佳宏

    消化器内視鏡   34 ( 12 )   1976 - 1980   2022年12月   ISSN:09153217

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    出版者・発行元:東京医学社  

    DOI: 10.24479/endo.0000000565

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  • Gastric endoscopic submucosal dissection assisted by intralesional cross-traction using silicone bands 国際誌

    Suzuki, Y; Esaki, M; Inada, T; Minoda, Y; Ogino, H; Ihara, E; Ogawa, Y

    ENDOSCOPY   55 ( S 01 )   E324-E325 - E325   2022年12月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-1982-3875

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  • 上部消化管疾患の低侵襲治療 食道・胃噴門部平滑筋腫に対してPOETおよびPOEM手技併用の内視鏡外科手術で低侵襲に核出し得た6例

    水流 大尭, 和田 将史, 畑 佳孝, 長友 周三郎, 江崎 充, 蓑田 洋介, 田中 義将, 荻野 治栄, 進藤 幸治, 森山 大樹, 大内田 研宙, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   120回・114回   115 - 115   2022年12月

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    記述言語:日本語  

  • 上部消化管疾患の低侵襲治療 食道・胃噴門部平滑筋腫に対してPOETおよびPOEM手技併用の内視鏡外科手術で低侵襲に核出し得た6例

    水流 大尭, 和田 将史, 畑 佳孝, 長友 周三郎, 江崎 充, 蓑田 洋介, 田中 義将, 荻野 治栄, 進藤 幸治, 森山 大樹, 大内田 研宙, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   120回・114回   115 - 115   2022年12月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-九州支部  

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  • Hybrid and Conventional Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multi-Center Randomized Controlled Trial 国際誌

    Esaki, M; Ihara, E; Sumida, Y; Fujii, H; Takahashi, S; Haraguchi, K; Iwasa, T; Somada, S; Minoda, Y; Ogino, H; Tagawa, K; Ogawa, Y

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   21 ( 7 )   1810 - 1818   2022年11月   ISSN:1542-3565 eISSN:1542-7714

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Gastroenterology and Hepatology  

    BACKGROUND & AIMS: Hybrid endoscopic submucosal dissection (H-ESD), which incorporates ESD with endoscopic mucosal resection, has been developed to make ESD technically easier. This study aimed to determine if H-ESD is superior to conventional ESD (C-ESD) for small early gastric neoplasms (EGN). METHODS: We conducted a multi-center, prospective, open-label, randomized controlled trial to compare the treatment outcomes of H-ESD and C-ESD (Hybrid-G Trial). The patients with differentiated-type intramucosal EGN ≤ 20 mm in diameter and without ulceration were randomly assigned (1:1) to groups that underwent H-ESD or C-ESD. A single multi-functional snare, SOUTEN (ST1850-20, Kaneka, Medix, Tokyo, Japan), was used for H-ESD. The primary outcome was procedure time. Secondary outcomes included mucosal incision time, time and speed of submucosal dissection, curability, and endoscopic procedural adverse events. RESULTS: A total of 39 and 40 patients underwent H-ESD and C-ESD, respectively. The procedure time of H-ESD was significantly shorter than that of C-ESD (33.16 min vs. 62.46 min, H-ESD/C-ESD ratio: 0.53, 95&#37; confidence interval 0.41-0.69, P<0.0001). There was no significant difference in mucosal incision time between the two groups; the time and speed of submucosal dissection of H-ESD were significantly shorter than those of C-ESD. No difference was observed between the two groups in other outcomes. CONCLUSIONS: H-ESD has significantly shorter procedure time than C-ESD, with high and comparable curability and safety for both H-ESD and C-ESD. H-ESD can be a good option for the endoscopic treatment of small EGNs.

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  • Auxiliary diagnosis of subepithelial lesions by impedance measurement during EUS-guided fine-needle biopsy 国際誌

    Minoda, Y; Esaki, M; Ihara, E; Nagatomo, S; Nishioka, K; Fujimori, N; Ogino, H; Bai, XP; Tanaka, Y; Chinen, T; Hu, QJ; Ota, M; Umekita, S; Yamamoto, H; Ogawa, Y

    GASTROINTESTINAL ENDOSCOPY   97 ( 5 )   977 - 984   2022年11月   ISSN:0016-5107 eISSN:1097-6779

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gastrointestinal Endoscopy  

    INTRODUCTION: Endoscopic ultrasound guided fine-needle aspiration/biopsy (EUS-FNA/B) is the gold standard for diagnosing subepithelial lesions (SELs); however, its diagnostic ability for SELs <20 mm is low. We developed a new diagnostic method to differentiate between gastrointestinal stromal tumor (GIST) and non-GIST by measuring high-frequency impedance (H-impedance) using an EUS-FNB needle. METHODS: The H-impedance of gastric epithelial neoplasms from 16 cases were measured using a conventional impedance probe to confirm whether H-impedance is clinically useful for assessing cell density (Study 1). The H-impedance values of exposed SELs from 25 cases using the conventional probe (Study 2) and non-exposed SELs from 20 cases using the EUS-FNB needle probe (Study 3) were measured to determine the diagnostic ability of H-impedance for differentiating GISTs from non-GISTs. RESULTS: H-impedance significantly positively correlated with cell density (P=0.030) (Study 1). The H-impedance of GIST (99.5) measured using conventional probe was significantly higher than those of the muscular layer (82.4) and leiomyoma (89.2) (P<0.01) (Study 2). The H-impedance of GIST measured using the EUS-FNB needle was also significantly higher than that of leiomyoma (GIST: 80.2 vs. leiomyoma: 71.8, P=0.015). The diagnostic yield of the impedance method for differentiating GISTs from non-GISTs had 94.4% accuracy, 88.9% sensitivity, 100% specificity, and 0.95 area under the curve. Diagnostic ability was not affected by lesion size (P=0.86) (Study 3). CONCLUSION: Auxiliary differential diagnosis between gastric GISTs and non-GISTs by the H-impedance measurement during EUS-FNB could be a good option especially when the lesion is smaller than 20 mm.

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  • 蠕動波出現と食道胃接合部上膨隆所見を用いた食道運動障害性疾患スクリーニングの食道造影改善(Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning)

    Hata Yoshitaka, Ihara Eikichi, Wada Masafumi, Tsuru Hirotaka, Muta Kazumasa, Minoda Yosuke, Bai Xiaopeng, Esaki Mitsuru, Tanaka Yoshimasa, Chinen Takatoshi, Ogino Haruei, Sakamoto Ryuichi, Ogawa Yoshihiro

    Journal of Gastroenterology   57 ( 11 )   838 - 847   2022年11月   ISSN:0944-1174

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    記述言語:英語   出版者・発行元:シュプリンガー・ジャパン(株)  

    食道運動障害性疾患(EMD)を診断するための新たな2所見を用いたバリウム食道造影検査(BE)によるスクリーニングを評価した。2013年1月から2020年10月にEMDが疑われ高解像度マノメトリー検査(HRM)とBEの両方が施行された244例を対象とした。EMDの診断はシカゴ分類第3.0版を用いてHRM所見に基づいて行った。BEは硫酸バリウムを用いて食道連続撮影を行った。従来からのBE所見(ニボー、数珠状/コルク栓抜き様所見、蠕動の消失/減弱)に加え、新規2所見(蠕動波出現、胃食道接合部上膨隆所見)を診断に用いた。新規2所見と従来の3所見を診断に用いた場合のBEスクリーニングの感度は79.4%、特異度は88%であった(受信者動作特性曲線下領域(AUC)=0.837)。新規2所見を診断に用いない場合には、感度は63.9%、特異度は96%(AUC=0.800)であった。アカラシアはニボー形成と特に関連性が強かった(88.7%)。収縮の消失は蠕動の消失/減弱と強く関連していた(85.7%)。遠位食道痙攣と数珠状/コルク栓抜き様所見との間(60%)およびアカラシアと蠕動波出現(59.7%)との間には比較的高い関連性が認められた。個々のBE所見の観察者内再現性、観察者間一致率はそれぞれ84.4%、75%であった。蠕動波出現は積算弛緩圧(IRP)高値および遠位潜時短縮と関連していた。食道胃接合部上膨隆はIRP高値と関連していた。新規の2所見を追加したBEスクリーニングによるEMDの診断は一般診療において有用である可能性が示された。

  • Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors 国際誌

    Minoda, Y; Ihara, E; Fujimori, N; Nagatomo, S; Esaki, M; Hata, Y; Bai, X; Tanaka, Y; Ogino, H; Chinen, T; Hu, Q; Oki, E; Yamamoto, H; Ogawa, Y

    SCIENTIFIC REPORTS   12 ( 1 )   16640 - 16640   2022年10月   ISSN:2045-2322

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    Gastrointestinal stromal tumors (GISTs) are common subepithelial lesions (SELs) and require treatment considering their malignant potential. We recently developed an endoscopic ultrasound-based artificial intelligence (EUS-AI) system to differentiate GISTs from non-GISTs in gastric SELs, which were used to train the system. We assessed whether the EUS-AI system designed for diagnosing gastric GISTs could be applied to non-gastric GISTs. Between January 2015 and January 2021, 52 patients with non-gastric SELs (esophagus, n = 15; duodenum, n = 26; colon, n = 11) were enrolled. The ability of EUS-AI to differentiate GISTs from non-GISTs in non-gastric SELs was examined. The accuracy, sensitivity, and specificity of EUS-AI for discriminating GISTs from non-GISTs in non-gastric SELs were 94.4%, 100%, and 86.1%, respectively, with an area under the curve of 0.98 based on the cutoff value set using the Youden index. In the subanalysis, the accuracy, sensitivity, and specificity of EUS-AI were highest in the esophagus (100%, 100%, 100%; duodenum, 96.2%, 100%, 0%; colon, 90.9%, 100%, 0%); the cutoff values were determined using the Youden index or the value determined using stomach cases. The diagnostic accuracy of EUS-AI increased as lesion size increased, regardless of lesion location. EUS-AI based on gastric SELs had good diagnostic ability for non-gastric GISTs.

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  • Circumferential suture delivery method of polyglycolic acid sheets for gastric postendoscopic submucosal dissection ulcers 国際誌

    Suzuki, Y; Osoegawa, T; Kubokawa, M; Esaki, M; Minoda, Y; Ogino, H; Ihara, E

    ENDOSCOPY   55 ( S 01 )   E68-E69 - E69   2022年9月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-1934-9752

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  • Randomized controlled trial comparing conventional and traction endoscopic submucosal dissection for early colon tumor (CONNECT-C trial) 国際誌

    Ichijima, R; Ikehara, H; Sumida, Y; Inada, T; Nemoto, D; Nakajima, Y; Minagawa, T; Sumiyoshi, T; Inoki, K; Yoshida, N; Inoue, K; Fukuzawa, M; Minoda, Y; Tsutsumi, K; Esaki, M; Gotoda, T

    DIGESTIVE ENDOSCOPY   35 ( 1 )   86 - 93   2022年8月   ISSN:0915-5635 eISSN:1443-1661

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Digestive Endoscopy  

    OBJECTIVES: Endoscopic submucosal dissection (ESD) is a widely used treatment for early gastrointestinal cancer. However, colon ESD remains challenging. Previous studies on colon ESD using the traction method used a small-sample, single-center design, providing insufficient evidence of this procedure's efficacy. We thus aimed to investigate the efficacy and safety of the traction method in colon ESD in this multicenter randomized trial. METHODS: We conducted a prospective, multicenter, randomized, two-arm controlled trial at 10 facilities in Japan. A 1:1 allocation was conducted for the conventional ESD (C-ESD) and traction ESD (T-ESD) groups. The primary endpoint was ESD procedure time. RESULTS: We included 128 C-ESD and 123 T-ESD cases from April 2020 to August 2021. The median procedure times for C-ESD and T-ESD were 61 (40-100) and 53 (40-76) min (p=0.18), respectively, and no significant differences were observed between the groups. Subgroup analysis showed that the median procedure times for patients with a lesion diameter of ≥30 mm in the C-ESD and T-ESD groups were 89 (57-80) and 69 (50-104) min (p=0.05), respectively, and for non-expert operators were 81 (62-120) and 64 (52-109) min (p=0.07), respectively. CONCLUSIONS: The traction method did not contribute to a significantly shortened ESD procedure time. However, this method may be useful when the tumor diameter is large or if the procedure is conducted by non-expert endoscopists.

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  • Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning

    Hata, Y; Ihara, E; Wada, M; Tsuru, H; Muta, K; Minoda, Y; Bai, XP; Esaki, M; Tanaka, Y; Chinen, T; Ogino, H; Sakamoto, R; Ogawa, Y

    JOURNAL OF GASTROENTEROLOGY   57 ( 11 )   838 - 847   2022年8月   ISSN:0944-1174 eISSN:1435-5922

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Gastroenterology  

    BACKGROUND: High-resolution manometry (HRM) is the gold standard for diagnosing esophageal motility disorders (EMDs); however, it requires specialized equipment. The development of more accessible screening examinations is expected. We evaluated the utility of barium esophagography (BE) screening using two novel findings to diagnose EMDs. METHODS: Between January 2013 and October 2020, 244 patients with suspected EMDs who underwent both HRM and BE were analyzed. The EMD diagnosis was based on HRM findings using Chicago Classification version 3.0. BE was performed using sequential esophagography with barium sulfate. Three conventional BE findings (air-fluid level, rosary-bead/corkscrew appearance, and absent/weak peristalsis) and two novel BE findings (wave appearance and supra-junctional ballooning) were used for diagnosis. RESULTS: The sensitivity and specificity of BE screening using the two novel findings and conventional findings to diagnose EMDs were 79.4&#37; and 88&#37;, respectively [area under the receiver-operating characteristic curve (AUC) = 0.837]. Without these novel findings, they were 63.9&#37; and 96&#37;, respectively (AUC = 0.800), respectively. Achalasia was highly correlated with the air-fluid level (88.7&#37;). Absent contractility was highly correlated with absent/weak peristalsis (85.7&#37;). Relatively high correlations were observed between distal esophageal spasm and rosary-bead/corkscrew appearance (60&#37;), and between achalasia and wave appearance (59.7&#37;). The intra-observer reproducibility and inter-observer agreement for individual BE findings were 84.4&#37; and 75&#37;, respectively. Wave appearance was associated with higher integrated relaxation pressure (IRP) and shorter distal latency. Supra-junctional ballooning was associated with higher IRP. CONCLUSIONS: BE screening using two additional novel findings to diagnose EMDs could be useful in general practice.

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  • Complete closure of mucosal defect after colonic endoscopic submucosal dissection using clip with a silicone traction band 国際誌

    Maehara, K; Esaki, M; Sumida, Y; Fukuda, S; Minoda, Y; Ihara, E; Akiho, H

    ENDOSCOPY   54 ( S 02 )   E1005 - E1006   2022年8月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-1889-4838

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  • 特集 症例から学ぶ胃ESD-改訂ガイドラインwith and beyond- [各論 痛恨の症例から学ぶ] 《TOPICS》ESDのための胃癌範囲診断

    江崎 充, 蓑田 洋介, 伊原 栄吉

    消化器内視鏡   34 ( 7 )   1225 - 1228   2022年7月   ISSN:09153217

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    出版者・発行元:東京医学社  

    DOI: 10.24479/endo.0000000262

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  • Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy 国際誌

    Minoda, Y; Ihara, E; Itaba, S; Sumida, Y; Haraguchi, K; Aso, A; Mizutani, T; Osoegawa, T; Esaki, M; Nagatomo, S; Nishioka, K; Muta, K; Bai, XP; Ogino, H; Fujimori, N; Tsurumaru, D; Ohuchida, K; Qingjiang, H; Oki, E; Yamamoto, H; Ogawa, Y

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   37 ( 1 )   101 - 108   2022年7月   ISSN:0930-2794 eISSN:1432-2218

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Surgical Endoscopy  

    BACKGROUND: Mucosal incision-assisted biopsy (MIAB) is a valuable alternative to endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNAB) for sampling gastric subepithelial lesions (SELs). This study aimed to evaluate the potential risk of dissemination and impact on postoperative prognosis associated with MIAB, which has not yet been investigated. METHODS: Study 1: A prospective observational study was conducted to examine the presence or absence and growth rate of tumor cells in gastric juice before and after the procedure in patients with SELs who underwent MIAB (n = 25) or EUS-FNAB (n = 22) between September 2018 and August 2021. Study 2: A retrospective study was conducted to examine the impact of MIAB on postoperative prognosis in 107 patients with gastrointestinal stromal tumors diagnosed using MIAB (n = 39) or EUS-FNAB (n = 68) who underwent surgery between January 2001 and July 2020. RESULTS: In study 1, although no tumor cells were observed in gastric juice in MIAB before the procedure, they were observed in 64&#37; of patients after obtaining samples (P < 0.001). In contrast, no tumor cells were observed in the gastric juice in EUS-FNAB before and after the procedure. In study 2, there was no significant difference in 5-year disease-free survival between MIAB (100&#37;) and EUS-FNAB (97.1&#37;) (P = 0.27). CONCLUSION: MIAB is safe, with little impact on postoperative prognosis, although the procedure releases some tumor cells after damaging the SEL's pseudocapsule.

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  • Innovative endoscopic submucosal dissection for early gastric neoplasm using intralesional traction and snaring techniques 国際誌

    Shoguchi, Y; Esaki, M; Minoda, Y; Bai, XP; Ogino, H; Ihara, E; Ogawa, Y

    ENDOSCOPY   54 ( S 02 )   E865-E866 - E866   2022年6月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

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  • 消化器診療における若手医師へのトレーニングと技術習得法の工夫 切除豚を用いたESDモデルによるハンズオントレーニングの経験

    江崎 充, 蓑田 洋介, 畑 佳孝, 荻野 治栄, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   119回・113回   98 - 98   2022年6月

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    記述言語:日本語  

  • 早期胃癌への内視鏡治療に関する多施設共同研究の経験

    友枝 成, 江崎 充, 蓑田 洋介, 隅田 頼信, 藤井 宏行, 岩佐 勉, 北川 祐介, 原口 和大, 杣田 真一, 和田 将史, 畑 佳孝, 荻野 治栄, 伊原 栄吉, 小川 佳宏

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   119回・113回   69 - 69   2022年6月

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    記述言語:日本語  

  • 早期胃癌への内視鏡治療に関する多施設共同研究の経験

    友枝 成, 江崎 充, 蓑田 洋介, 隅田 頼信, 藤井 宏行, 岩佐 勉, 北川 祐介, 原口 和大, 杣田 真一, 和田 将史, 畑 佳孝, 荻野 治栄, 伊原 栄吉, 小川 佳宏

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   119回・113回   69 - 69   2022年6月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-九州支部  

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  • 消化器診療における若手医師へのトレーニングと技術習得法の工夫 切除豚を用いたESDモデルによるハンズオントレーニングの経験

    江崎 充, 蓑田 洋介, 畑 佳孝, 荻野 治栄, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   119回・113回   98 - 98   2022年6月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-九州支部  

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  • Ampullary Neuroendocrine Neoplasm: Clinicopathological Characteristics and Novel Endoscopic Entity 国際誌

    Matsumoto, K; Fujimori, N; Hata, Y; Minoda, Y; Murakami, M; Teramatsu, K; Takamatsu, Y; Takeno, A; Oono, T; Ihara, E; Nakata, K; Nakamura, M; Yamamoto, T; Koga, Y; Oda, Y; Ito, T; Ogawa, Y

    DIGESTIVE DISEASES   41 ( 2 )   316 - 324   2022年5月   ISSN:0257-2753 eISSN:1421-9875

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Digestive Diseases  

    BACKGROUND: Neuroendocrine neoplasms of the ampulla of Vater (ampullary NEN) have features of both gastrointestinal and pancreato-biliary (PB) NEN. However, the limited number of studies examining ampullary NEN makes it difficult to clarify their unique characteristics. This study aimed to elucidate the clinical characteristics of ampullary NEN. METHODS: We enrolled 162 patients with PB-NEN diagnosed at Kyushu University Hospital between 2011 and 2020. Clinical features, pathological diagnoses, treatments, and prognoses were retrospectively analyzed. We also compared ampullary NEN with pancreatic NEN (PanNEN). RESULTS: We analyzed 10 ampullary NEN cases and 149 PanNEN cases. The ampullary NEN cases consisted of four cases of NET G1 (neuroendocrine tumor Grade 1), one NET G2 (Grade 2), and five NECs (neuroendocrine carcinoma). The incidences of NEC and cholangitis were significantly higher in ampullary NEN than in PanNEN. All ampullary NETs had a submucosal tumor-like appearance, as identified by endoscopic ultrasound-guided fine needle aspiration. We treated small NET G1 (<10 mm) with endoscopic papillectomy and large NET G1 with pancreaticoduodenectomy. There were no cases of recurrence after resection. All ampullary NECs presented with the characteristic endoscopic finding of a ''crater sign" similar to deep-mining ulcers seen in gastric malignant lymphoma. Four cases underwent surgical resection, and one case was unresectable. Two patients who underwent multidisciplinary treatment were maintained without recurrence for over 2 years. CONCLUSIONS: Endoscopic findings showed identifiable distinctions between ampullary NETs and NECs.

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  • Comparisons of outcomes between ProKnife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial 国際誌

    Esaki, M; Ihara, E; Esaki, M; Nishioka, K; Kimura, Y; Hata, Y; Tsuru, H; Wada, M; Minoda, Y; Bai, XP; Shoguchi, Y; Nasu, T; Nagatomo, S; Muta, K; Ogino, H; Ogawa, Y

    DEN OPEN   2 ( 1 )   e91   2022年4月   ISSN:2692-4609

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:DEN Open  

    Objective: To compare treatment outcomes between injection endoscopic submucosal dissection using ProKnife (P-ESD) and conventional ESD (C-ESD) for gastric lesions. Methods: In this randomized controlled trial, we compared treatment outcomes of P-ESD and C-ESD for simulated gastric lesions ≥3 cm in resected porcine stomachs. Predictive factors associated with ESD difficulties were investigated using logistic regression analysis. Results: Seventy lesions were screened; however, two lesions were excluded. A total of 12 endoscopists performed 68 ESDs: 34 P-ESDs and 34 C-ESDs. The ESD procedure time of P-ESD (36.3 [28.4-46.8] min) was significantly shorter than that of C-ESD (46 [36.4-64.6] min; p = 0.0014). The technical success rates did not differ between the P-ESD and C-ESD groups (en bloc resection rate, 100% in both groups; complete resection rate, 94.1% and 85.3%, respectively; p = 0.23). The number of injections during P-ESD (7.5 [6-10] times) was significantly higher than during C-ESD (4 [3-5] times; p < 0.001), but the total volume of injected solution during P-ESD (20 [16-26.3] ml) was significantly smaller than during C-ESD (27.5 [20-31.5] ml; p = 0.0019). In multivariate analysis, less ESD experience (odds ratio [OR], 3.9) and selection of C-ESD as the ESD method (OR, 3.8) were independent predictive factors associated with ESD difficulties. Conclusions: Compared with C-ESD, P-ESD had a shorter procedure time but also allowed for notable technical success and safety.

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  • Application of intralesional traction assistance with traction wire to endoscopic submucosal dissection for colorectal neoplasms 招待 査読 国際誌

    Nasu T, Esaki M, Shoguchi Y, Bai X, Minoda Y, Ogino H, Ihara E.

    ENDOSCOPY   2022年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-1809-4967

  • Self-completion method of endoscopic submucosal dissection using the Endosaber for treating colorectal neoplasms (with video). 国際誌

    Mitsuru Esaki, Shun Yamakawa, Ryoji Ichijima, Sho Suzuki, Chika Kusano, Hisatomo Ikehara, Yosuke Minoda, Eikichi Ihara, Takuji Gotoda

    Scientific reports   12 ( 1 )   5821 - 5821   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Endoscopic submucosal dissection (ESD) is effective for the treatment of colorectal neoplasms. We have developed a self-completion ESD (S-ESD) using Endosaber without requiring additional instruments or assistance. This prospective cohort study was conducted to investigate the feasibility of S-ESD for colorectal neoplasms. Patients with colorectal neoplasms measuring 20-40 mm in size were enrolled. A single operator, without assistance, performed ESD using only the Endosaber. The primary outcome was the success rate of S-ESD. Secondary outcomes included procedure time, the rates of en bloc, complete, and curative resection, and complication rates, including the incidence of perforation and delayed bleeding. In total, 15 patients with 15 lesions were enrolled. The median size of the resected lesions was 28 mm (interquartile range 25-29 mm). S-ESD success rate of 100&#37; was achieved. The median procedure time was 44 min (29.5-53.5 min). We observed en bloc, complete, and curative resection rates of 100&#37;, 93.3&#37;, and 86.7&#37;, respectively, and a complication rate of 6.7&#37; (perforation: 0&#37;, delayed bleeding: 6.7&#37;). S-ESD for colorectal neoplasms was successfully performed with favorable treatment outcomes and low complication rates. S-ESD reduces the number of devices and extent of assistance, making S-ESD a simple and cost-effective procedure.

    DOI: 10.1038/s41598-022-09792-8

  • Self-completion method of endoscopic submucosal dissection using the Endosaber for treating colorectal neoplasms (with video) 招待 査読 国際誌

    Esaki M, Yamakawa S, Ichijima R, Suzuki S, Kusano C, Ikehara H, Minoda Y, Ihara E, Gotoda T.

    SCIENTIFIC REPORTS   12 ( 1 )   2022年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-022-09792-8

  • Application of intralesional traction assistance with traction wire to endoscopic submucosal dissection for colorectal neoplasms. 国際誌

    Takayuki Nasu, Mitsuru Esaki, Yoshihisa Shoguchi, Xiaopeng Bai, Yosuke Minoda, Haruei Ogino, Eikichi Ihara

    Endoscopy   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-1809-4967

  • Ex vivoブタモデルを用いた、大きな胃病変に対するProKnife注入内視鏡的粘膜下層剥離術と従来法の内視鏡的粘膜下層剥離術の比較 無作為化対照試験(Comparisons of outcomes between ProKnife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial)

    Esaki Mitsuru, Ihara Eikichi, Esaki Misato, Nishioka Kei, Kimura Yusuke, Hata Yoshitaka, Tsuru Hirotaka, Wada Masafumi, Minoda Yosuke, Bai Xiaopeng, Shoguchi Yoshihisa, Nasu Takayuki, Nagatomo Shuzaburo, Muta Kazumasa, Ogino Haruei, Ogawa Yoshihiro

    DEN Open   2 ( 1 )   1 of 8 - 8 of 8   2022年4月

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

    Ex vivoブタモデルの胃病変70ヵ所に対して、ProKnifeを用いた内視鏡的粘膜下層剥離術(P-ESD)または従来法の内視鏡的粘膜下層剥離術(C-ESD)を無作為に振り分け、12名の内視鏡医が施行した。各群1病変を粘膜肥厚のため除外したことにより、検討対象は各群34病変となった。処置時間はP-ESD群が36.3(28.4-46.8)分、C-ESD群が46(36.4-64.6)分で、有意にP-ESD群が短かった(P=0.0014)。技術的成功率には差は認められなかった(一括切除率は両群とも100%、完全切除率はP-ESD群94.1%、C-ESD群85.3%、P=0.23)。P-ESD処置中の注入回数は7.5(6-10)回で、C-ESD群の4(3-5)回よりも有意に多かった(P<0.001)が、注入薬液総量はP-ESD群が20(16-26.3)ml、C-ESD群が27.5(20-31.5)mlで、P-ESD群が有意に少なかった(P=0.0019)。多変量解析の結果、ESD未熟練(オッズ比(OR)3.9)、C-ESD法(OR3.8)がESD困難性の独立した予測因子であった。

  • 胃食道流出路閉塞に対するアコチアミドの治療有効性 前向き縦断的観察研究(The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study)

    Ihara Eikichi, Ogino Haruei, Muta Kazumasa, Hamada Shohei, Wada Masafumi, Hata Yoshitaka, Ikeda Hiroko, Bai Xiaopeng, Minoda Yosuke, Esaki Mitsuru, Tanaka Yoshimasa, Chinen Takatoshi, Ogawa Yoshihiro

    Esophagus   19 ( 2 )   332 - 342   2022年4月   ISSN:1612-9059

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    記述言語:英語   出版者・発行元:シュプリンガー・ジャパン(株)  

    消化管運動改善薬であるアコチアミドの、食道胃接合部流出路閉塞(EGJOO)に対する有効性を検討した。2014年10月から2020年3月までの間に、EGJOO 25例に対してアコチアミド(100mg、1日3回)を4週間投与した。治療開始直前と治療後に高解像度マノメトリー検査(HRM)を施行した。主要評価項目である積算弛緩厚(IRP)は、治療前(19.4、17.1-27.4mmHg)と比較して治療後(14.6、12.1-22.0mmHg)で有意に低かった。下部食道括約筋(LES)調節指数も、治療後(32.7,21.0-40.0mmHg)が治療前(39.3,31.2-50.2mmHg)と比較して有意に低かった。アコチアミドは、EGJOO25症例中13例(52%)でIRPを正常化(<15mmHg)し、IRPは25例のEGJOO症例中20例(80%)でIRPを減少させた。副次評価項目であるFSSGスコアには、治療前と治療後で有意な変化は認められなかった。アコチアミドが奏効した13例を対象としたサブグループ解析では、アコチアミドにより嚥下障害が有意に改善していた。アコチアミドは、基礎LES圧およびLES調節反応の両方を低下させることによりIRP値を減少させることで、EGJOO患者において治療効果を示すことが明らかになった。

  • What is the best modality for diagnosing pancreatic cancer? 国際誌

    Fujimori, N; Minoda, Y; Ogawa, Y

    DIGESTIVE ENDOSCOPY   34 ( 4 )   744 - 746   2022年3月   ISSN:0915-5635 eISSN:1443-1661

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    記述言語:英語   出版者・発行元:Digestive Endoscopy  

    DOI: 10.1111/den.14283

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  • Intralesional traction-assisted endoscopic submucosal dissection for early gastric neoplasm using the ProdiGI traction wire

    Shoguchi, Y; Esaki, M; Minoda, Y

    DIGESTIVE ENDOSCOPY   34 ( 3 )   E56 - E57   2022年3月   ISSN:0915-5635 eISSN:1443-1661

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    記述言語:英語   出版者・発行元:Digestive Endoscopy  

    DOI: 10.1111/den.14239

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  • Efficacy and timing of gastrografin administration after ileus tube insertion in patients with adhesive small bowel obstruction 国際誌

    Esaki, M; Tamura, Y; Ichijima, R; Suzuki, S; Iwamoto, M; Minoda, Y; Moriyama, M; Gotoda, T

    ARAB JOURNAL OF GASTROENTEROLOGY   23 ( 1 )   45 - 51   2022年2月   ISSN:1687-1979 eISSN:2090-2387

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Arab Journal of Gastroenterology  

    BACKGROUND AND STUDY AIMS: Gastrografin administration (GA) is performed for adhesive small bowel obstruction (ASBO) in cases when decompression therapy using an ileus tube fails to relieve the obstruction. This study evaluated the efficacy of GA and optimized its timing after ileus tube insertion. PATIENTS AND METHODS: In this retrospective study, we evaluated data from patients with ASBO admitted between January 2014 and August 2018 and included patients who underwent ileus tube intubation and GA. The patients were classified as those treated with GA within 48 h after admission (early GA [EGA]) and those treated later with GA (delayed GA [DGA]). Propensity score matching was performed to compensate for differences between the groups. Short-term outcomes were compared between the two groups. RESULTS: We included 67 and 80 patients in the EGA and DGA groups, respectively, and 55 pairs with similar background characteristics were matched. The rates of successful conservative management were 87.3% (48/55) in the EGA group, 96.4% (53/55) in the DGA group, and 91.8% (101/110) in the entire sample. The median period of ileus tube insertion in the DGA group was significantly lower than that in the EGA group, whereas other outcomes did not significantly differ between the groups. Aspiration pneumonia occurred in one patient in the EGA group. CONCLUSIONS: GA with an ileus tube achieved a high rate of successful conservative management. Follow-up using decompression with an ileus tube for at least 48 h after admission is recommended in patients with ASBO.

    DOI: 10.1016/j.ajg.2021.12.004

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  • Comparison of the procedure time differences between hybrid endoscopic submucosal dissection and conventional endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for a multi-center randomized controlled trial (Hybrid-G trial) 国際誌

    Esaki, M; Ihara, E; Fujii, H; Sumida, Y; Haraguchi, K; Takahashi, S; Iwasa, T; Nakano, K; Wada, M; Somada, S; Minoda, Y; Ogino, H; Tagawa, K; Ogawa, Y

    TRIALS   23 ( 1 )   166 - 166   2022年2月   eISSN:1745-6215

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Trials  

    BACKGROUND: Endoscopic submucosal dissection (ESD) is widely accepted as a local treatment for gastrointestinal tract tumors. As a simplified endoscopic procedure, hybrid ESD (H-ESD) has been performed for colorectal neoplasms in recent times. However, whether H-ESD is superior to conventional ESD (C-ESD) for patients with early gastric neoplasms (EGN) remains unclear. In this trial, we will compare the treatment outcomes of H-ESD and C-ESD. We hypothesize that the procedure time for H-ESD is shorter than that for C-ESD. METHODS: This is an investigator-initiated, multi-center, prospective, randomized, open-label, parallel-group trial to be conducted beginning in August 2020 at nine institutions in Japan. We will determine if H-ESD is superior to C-ESD in terms of procedure time in patients with EGN diagnosed as macroscopically intramucosal (T1a) differentiated carcinoma ≤ 20 mm in diameter without ulcerative findings according to current Japanese gastric cancer treatment guidelines. A total of 82 patients will be recruited and randomly assigned to either the C-ESD or the H-ESD group. The primary outcome is ESD procedure time. Secondary outcomes include mucosal incision, time and speed of submucosal dissection, en bloc resection, complete resection, curability, adverse events related to the ESD procedure, extent of dissection before snaring, volume of injection solution, number and time of hemostasis, thickness of the submucosal layer in the resected specimen, and handover to another operator. The stated sample size was determined based on the primary outcome. According to a previous report comparing the procedure times of C-ESD and H-ESD, we hypothesized that H-ESD would provide a 0.2 reduction in logarithmically concerted procedure time (-37%). We estimated that a total of 82 participants were needed to reach a power of 80% for a t-test with a significance level of 0.05 and considering a 10% dropout. DISCUSSION: This trial will provide high-quality data on the benefits and risks of H-ESD for EGN patients. The results of this study could lead to improved outcomes in patients with EGN undergoing ESD. The results will be presented at national and international meetings and published in peer-reviewed journals. TRIAL REGISTRATION: UMIN-CTR UMIN000041244 . Registered on July 29, 2020.

    DOI: 10.1186/s13063-022-06099-x

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  • Efficacy and timing of gastrografin administration after ileus tube insertion in patients with adhesive small bowel obstruction 招待 査読 国際誌

    Esaki M, Tamura Y, Ichijima R, Suzuki S, Iwamoto M, Minoda Y, Moriyama M, Gotoda T.

    2022年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Comparison of the procedure time differences between hybrid endoscopic submucosal dissection and conventional endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for a multi-center randomized controlled trial (Hybrid-G trial) 招待 査読 国際誌

    Esaki M, Ihara E, Fujii H, Sumida Y, Haraguchi K, Takahashi S, Iwasa T, Nakano K, Wada M, Somada S, Minoda Y, Ogino H, Tagawa K, Ogawa Y.

    2022年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Is a small-caliber or large-caliber endoscope more suitable for colonic self-expandable metallic stent placement A randomized controlled study 国際誌

    Minoda, Y; Ogino, H; Sumida, Y; Osoegawa, T; Itaba, S; Hashimoto, N; Esaki, M; Kitagawa, Y; Yodoe, K; Iboshi, Y; Matsuguchi, T; Tadokoro, M; Chaen, T; Kubo, H; Kubokawa, M; Harada, N; Nishizima, K; Fujii, H; Hata, Y; Tanaka, Y; Ihara, E; Ogawa, Y

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   15   17562848211065331 - 17562848211065331   2022年1月   ISSN:1756-283X eISSN:1756-2848

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Therapeutic Advances in Gastroenterology  

    Objectives: The colonic self-expandable metallic stent (C-SEMS) with a 9-French (Fr) delivery system allows for a small-caliber endoscope (SCE) to be used to treat malignant colonic obstruction. Despite the lack of evidence, the SCE has become popular because it is considered easier to insert than the large-caliber endoscope (LCE). We aimed to determine whether the SCE is more suitable than the LCE for C-SEMS placement. Methods: Between July 2018 and November 2019, 50 consecutive patients who were scheduled to undergo C-SEMS for colon obstruction were recruited in this study. Patients were randomized to the SCE or LCE group. The SCE and LCE were used with 9-Fr and 10-Fr delivery systems, respectively. The primary outcome was the total procedure time. Secondary outcomes were the technical success rate, complication rate, clinical success rate, insertion time, guidewire-passage time, stent-deployment time, and colonic obstruction-scoring-system score. Results: Forty-five patients (SCE group, n = 22; LCE group, n = 23) were analyzed. The procedure time in the LCE group (median, 20.5 min) was significantly (p = 0.024) shorter than that in the SCE group (median, 25.1 min). The insertion time in the LCE group (median, 2.0 min) was significantly (p = 0.0049) shorter than that in the SCE group (median, 6.0 min). A sub-analysis of the procedure difficulties showed that the insertion time in the LCE group (median, 5.0 min) was significantly shorter than that in the SCE group (median, 8.5 min). Conclusion: Both LCE and SCE can be used for C-SEMS; however, LCE is more suitable than SCE as it achieved a faster and equally efficacious C-SEMS placement as that of SCE. Clinical trial registration number: University Hospital Medical Information Network Clinical Trials Registry (UMIN 32748).

    DOI: 10.1177/17562848211065331

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  • Is a small-caliber or large-caliber endoscope more suitable for colonic self-expandable metallic stent placement? A randomized controlled study 招待 査読 国際誌

    Minoda Y, Ogino H, Sumida Y, Osoegawa T, Itaba S, Hashimoto N, Esaki M, Kitagawa Y, Yodoe K, Iboshi Y, Matsuguchi T, Tadokoro M, Chaen T, Kubo H, Kubokawa M, Harada N, Nishizima K, Fujii H, Hata Y, Tanaka Y, Ihara E, Ogawa Y.

    2022年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Comparisons of outcomes between ProKnife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial 招待 査読 国際誌

    Esaki M, Ihara E, Esaki M, Nishioka K, Kimura Y, Hata Y, Tsuru H, Wada M, Minoda Y, Bai X, Shoguchi Y, Nasu T, Nagatomo S, Muta K, Ogino H, Ogawa Y.

    2022年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • 食道疾患に対する内視鏡治療の工夫 内視鏡・胸腔鏡合同手術で切除し食道運動機能を温存できた巨大食道平滑筋腫の2例

    水流 大尭, 蓑田 洋介, 和田 将史, 畑 佳孝, 長友 周三郎, 木村 勇祐, 西岡 慧, 江崎 充, 荻野 治栄, 進藤 幸治, 森山 大樹, 大内田 研宙, 伊原 栄吉

    日本消化管学会雑誌   6 ( Suppl. )   164 - 164   2022年1月

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    記述言語:日本語  

  • 消化管GIST診療の進歩と問題点 胃以外の消化管粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断の有用性

    蓑田 洋介, 水流 大尭, 和田 将史, 畑 佳孝, 長友 周三郎, 木村 勇祐, 西岡 慧, 江崎 充, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   6 ( Suppl. )   133 - 133   2022年1月

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    記述言語:日本語  

  • 食道疾患に対する内視鏡治療の工夫 内視鏡・胸腔鏡合同手術で切除し食道運動機能を温存できた巨大食道平滑筋腫の2例

    水流 大尭, 蓑田 洋介, 和田 将史, 畑 佳孝, 長友 周三郎, 木村 勇祐, 西岡 慧, 江崎 充, 荻野 治栄, 進藤 幸治, 森山 大樹, 大内田 研宙, 伊原 栄吉

    日本消化管学会雑誌   6 ( Suppl. )   164 - 164   2022年1月   ISSN:2433-3840 eISSN:2435-8967

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • 消化管GIST診療の進歩と問題点 胃以外の消化管粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断の有用性

    蓑田 洋介, 水流 大尭, 和田 将史, 畑 佳孝, 長友 周三郎, 木村 勇祐, 西岡 慧, 江崎 充, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   6 ( Suppl. )   133 - 133   2022年1月   ISSN:2433-3840 eISSN:2435-8967

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  • 十二指腸非乳頭部腫瘍診療における課題と治療戦略 胃型の非乳頭部十二指腸腫瘍に対する内視鏡治療の現状と選択

    蓑田 洋介, 伊原 栄吉, 山元 英崇, 江崎 充, 畑 佳孝, 佐々木 泰介, 荻野 治栄, 小川 佳宏

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   118回・112回   92 - 92   2021年12月

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    記述言語:日本語  

  • Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps 招待 査読 国際誌

    Esaki M, Esaki M, Maehara K, Minoda Y, Ogino H, Ihara E, Ogawa Y.

    2021年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Traction-assisted hybrid endoscopic submucosal dissection for small rectal neuroendocrine tumors 国際誌

    Nasu, T; Esaki, M; Shoguchi, Y; Bai, XP; Minoda, Y; Ogino, H; Ihara, E

    ENDOSCOPY   54 ( 10 )   E550 - E551   2021年11月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-1662-4965

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  • 【胃食道逆流症(GERD)ガイドラインの改正をめぐって】Barrett食道の発癌予防の諸問題

    畑 佳孝, 伊原 栄吉, 和田 将史, 水流 大尭, 江崎 充, 蓑田 洋介, 白 暁鵬, 田中 義将, 荻野 治栄

    消化器・肝臓内科   10 ( 5 )   551 - 560   2021年11月

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    記述言語:日本語  

  • Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps. 国際誌

    Misato Esaki, Mitsuru Esaki, Kosuke Maehara, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy international open   9 ( 11 )   E1845-E1846   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-1576-7673

  • The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study

    Ihara, E; Ogino, H; Muta, K; Hamada, S; Wada, M; Hata, Y; Ikeda, H; Bai, X; Minoda, Y; Esaki, M; Tanaka, Y; Chinen, T; Ogawa, Y

    ESOPHAGUS   19 ( 2 )   332 - 342   2021年10月   ISSN:1612-9059 eISSN:1612-9067

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Esophagus  

    OBJECTIVES: We have found that an altered lower esophageal sphincter (LES) accommodation response is an underlying cause of esophagogastric junction outflow obstruction (EGJOO). The objective of this study was to examine the treatment effect of acotiamide, a prokinetic agent which improves impaired gastric accommodation in functional dyspepsia, in patients with EGJOO. METHODS: A prospective observational longitudinal study was conducted between October 2014 and March 2020. Acotiamide (100 mg, 3 times a day) was administered to 25 patients with EGJOO for 4 weeks. High-resolution manometry (HRM) was performed just before and after 4 weeks of treatment. RESULTS: As the primary outcome, the extent of integrated relaxation pressure (IRP) after treatment (14.6, 12.1-22.0 mmHg) was significantly lower than that before treatment (19.4, 17.1-27.4 mmHg). The extent of LES accommodation index after treatment (32.7, 21.0-40.0 mmHg) was also significantly lower than that before treatment (39.3, 31.2-50.2 mmHg). Acotiamide normalized the IRP (< 15 mmHg) in 13 of 25 patients with EGJOO (52&#37;), and the IRP was decreased in 20 of 25 patients with EGJOO (80&#37;). As the secondary outcome, the total FSSG score in 25 patients with EGJOO before and after acotiamide treatment showed no significant difference. In a sub-analysis of 13 patients in whom EGJOO was normalized by acotiamide, however, dysphagia was reported to be significantly improved by acotiamide. CONCLUSIONS: Acotiamide has a treatment effect on patients with EGJOO via a reduction in the IRP level through the lowering of both the basal LES pressure and LES accommodation response. Dysphagia is a key symptom to be evaluated and treated in patients with EGJOO.

    DOI: 10.1007/s10388-021-00887-1

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  • 【膵と胆道の先天性形成異常~発生から臨床まで~】異所性膵の診断

    蓑田 洋介, 長友 周三郎, 西岡 慧, 江崎 充, 荻野 治栄, 藤森 尚, 大野 隆真, 伊原 栄吉, 大久保 文彦, 佐々木 泰介, 小田 義直, 小川 佳宏

    胆と膵   42 ( 10 )   943 - 946   2021年10月

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    記述言語:日本語  

    異所性膵は胃角部から前庭部に多く発生する消化管粘膜下腫瘍として見つかることが多い疾患である。多くの異所性膵は良性で経過し診断がつけば基本的には経過観察が可能である。診断は上部消化管内視鏡検査ならびに超音波内視鏡を用いた画像診断や病理学的評価が有用とされている。超音波内視鏡による画像診断は非常に有用であるが、内部の性状だけでなく病変の由来層の確認が極めて重要である。また超音波内視鏡下吸引穿刺細胞診/生検以外の診断法として近年報告が増えている粘膜切開生検が、EUS-FNABで診断困難な症例における新たな診断オプションとして期待される。(著者抄録)

  • 膵癌患者由来オルガノイド樹立におけるEUS-FNABと経皮的肝腫瘍生検の有用性の検討(第一報)

    松本 一秀, 藤森 尚, 蓑田 洋介, 原 真児登, 梯 祥太郎, 安森 翔, 村上 正俊, 寺松 克人, 高松 悠, 長友 周三郎, 西岡 慧, 小森 圭司, 日置 智惟, 川元 美緒, 大野 隆真, 伊原 栄吉, 国府島 庸之, 小川 佳宏

    日本消化器病学会雑誌   118 ( 臨増大会 )   A728 - A728   2021年10月

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    記述言語:日本語  

  • Usefulness of a gel immersion-assisted EUS-guided fine-needle aspiration/biopsy for ampullary lesions (with videos) 国際誌

    Minoda Y., Nagatomo S., Fujimori N., Nishioka K., Kakehashi S., Teramatsu K., Takamatsu Y., Ogino H., Ihara E.

    Endoscopic Ultrasound   11 ( 2 )   143 - 144   2021年9月   ISSN:23039027

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopic Ultrasound  

    DOI: 10.4103/EUS-D-21-00043

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  • In Living Color: Linked Color Imaging for the Detection of Early Gastric Cancer 国際誌

    Esaki, M; Minoda, Y; Ihara, E

    DIGESTIVE DISEASES AND SCIENCES   67 ( 6 )   1922 - 1924   2021年8月   ISSN:0163-2116 eISSN:1573-2568

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    記述言語:英語   出版者・発行元:Digestive Diseases and Sciences  

    DOI: 10.1007/s10620-021-07235-4

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  • Ultra-thin endoscope-assisted insertion of a suction tube for the removal of massive gastric blood clots. 国際誌

    Kosuke Maehara, Mitsuru Esaki, Yosuke Minoda

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   33 ( 5 )   e106-e108   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.13990

  • Efficacy of hybrid endoscopic submucosal dissection with SOUTEN in gastric lesions: An ex vivo porcine model basic study. 国際誌

    Mitsuru Esaki, Eikichi Ihara, Norikazu Hashimoto, Shuichi Abe, Chihoko Aratono, Noriko Shiga, Yorinobu Sumida, Hiroyuki Fujii, Kazuhiro Haraguchi, Shunsuke Takahashi, Tsutomu Iwasa, Kayoko Nakano, Masafumi Wada, Shinichi Somada, Kei Nishioka, Yosuke Minoda, Haruei Ogino, Yoshihiro Ogawa

    World journal of gastrointestinal surgery   13 ( 6 )   563 - 573   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Hybrid endoscopic submucosal dissection (ESD) that comprises mucosal incision and partial submucosal dissection followed by snaring in a planned manner, has been developed for endoscopic resection of gastrointestinal neoplasms to overcome the technical barrier of ESD. Although the superiority of hybrid ESD with SOUTEN, a single multifunctional device, over conventional ESD has been indicated, the actual effect of snaring itself remains unclear since SOUTEN could be applied to hybrid ESD group, but not to the conventional ESD group, due to ethical issue in clinical practice. AIM: To determine whether and how hybrid ESD was superior to conventional ESD in the endoscopic treatment of gastric lesions in an ex vivo porcine model basic study. METHODS: Sixteen endoscopists participated in this basic study in August 2020 at Kyushu University, performing 32 procedures each for hybrid ESD and conventional ESD. Mock lesions (10-15 mm, diameter) were created in the porcine stomach. The primary outcome was total procedure time and secondary outcomes were en bloc or complete resection, perforation, procedure time/speed for both, mucosal incision, and submucosal dissection. Factors associated with difficulty in ESD including longer procedure time, incomplete resection, and perforation, were also investigated. Categorical and continuous data were analyzed using the chi-square test or Fisher's exact test and the Mann-Whitney U test, respectively. RESULTS: The median total procedure time of hybrid ESD was significantly shorter than that of conventional ESD (median: 8.3 min vs 16.2 min, P < 0.001). Time, speed, and the amount of hyaluronic acid during submucosal dissection were more favorable in hybrid ESD than conventional ESD (time, 5.2 min vs 10.4 min, P < 0.001; speed, 43.7 mm2/min vs 23.8 mm2/min, P < 0.00; injection volume, 1.5 mL vs 3.0 mL, P < 0.001), although no significant differences in those factors were observed between both groups during mucosal incision. There was also no significant difference between both groups in the en bloc/complete resection rate and perforation rate (complete resection, 93.8% vs 87.5%, P = 0.67; perforation, 0% vs 3.1%, P = 1). Selection of conventional ESD as the treatment method was significantly associated with difficulties during ESD (odds ratio = 10.2; highest among factors). CONCLUSION: Hybrid ESD with SOUTEN improves the treatment outcomes of gastric lesions. It also has the potential to reduce medical costs since SOUTEN is a single multifunctional device that is inexpensive.

    DOI: 10.4240/wjgs.v13.i6.563

  • 膵・消化管神経内分泌腫瘍の診断・治療の現状と問題点 当科における直腸神経内分泌腫瘍に対する診断・治療の現状と課題

    林 康代, 荻野 治栄, 蓑田 洋介, 田中 義将, 畑 佳孝, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   117回・111回   81 - 81   2021年6月

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    記述言語:日本語  

  • 膵・消化管領域における診断的EUSとEUS-FNAの現状と展望 十二指腸粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断の有用性

    蓑田 洋介, 長友 周三郎, 藤森 尚, 荻野 治栄, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   117回・111回   99 - 99   2021年6月

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    記述言語:日本語  

  • 膵・消化管神経内分泌腫瘍の診断・治療の現状と問題点 十二指腸乳頭部神経内分泌腫瘍の臨床的特徴の検討

    松本 一秀, 藤森 尚, 畑 佳孝, 蓑田 洋介, 村上 正俊, 寺松 克人, 高松 悠, 大野 隆真, 伊原 栄吉, 仲田 興平, 中村 雅史, 古賀 裕, 小田 義直, 伊藤 鉄英, 小川 佳宏

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   117回・111回   82 - 82   2021年6月

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    記述言語:日本語  

  • 内視鏡的に除去しえた自然脱落型膵管ステントのS状結憩室嵌頓の一例

    長友 周三郎, 蓑田 洋介, 藤森 尚, 梯 祥太郎, 江崎 珠里, 大塚 宜寛, 池田 浩子, 西岡 慧, 高松 悠, 寺松 克人, 荻野 治栄, 大野 隆真, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   117回・111回   168 - 168   2021年6月

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    記述言語:日本語  

  • Usefulness of preoperative site marking with an indocyanine green fluorescent clip for gastrointestinal stromal tumor. 国際誌

    Yosuke Minoda, Yuichi Hisamatsu, Eikichi Ihara

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   33 ( 5 )   e95-e96   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.13978

  • Application of traction-method to hybrid endoscopic submucosal dissection for gastrointestinal tumors 国際誌

    Esaki, M; Maehara, R; Nagatomo, S; Nishioka, K; Minoda, Y; Ogino, H; Ihara, E

    ENDOSCOPY   54 ( 04 )   E160 - E161   2021年4月   ISSN:0013-726X eISSN:1438-8812

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endoscopy  

    DOI: 10.1055/a-1422-2902

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  • 小児に対する内視鏡診療 全身麻酔下超音波内視鏡下穿刺吸引法(EUS-FNA)が治療方針決定に有用であった小児膵腫瘍の2例 小児におけるEUS-FNAの位置付け

    藤森 尚, 蓑田 洋介, 大野 隆真

    Gastroenterological Endoscopy   63 ( Suppl.1 )   835 - 835   2021年4月

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    記述言語:日本語  

  • ESD初学者における豚モデルを用いたハサミ系ナイフと先端系ナイフの比較検討

    市島 諒二, 江崎 充, 山川 俊, 蓑田 洋介, 鈴木 翔, 池原 久朝, 草野 央, 後藤田 卓志

    Gastroenterological Endoscopy   63 ( Suppl.1 )   949 - 949   2021年4月

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    記述言語:日本語  

  • ESD初学者における豚モデルを用いたハサミ系ナイフと先端系ナイフの比較検討

    市島 諒二, 江崎 充, 山川 俊, 蓑田 洋介, 鈴木 翔, 池原 久朝, 草野 央, 後藤田 卓志

    Gastroenterological Endoscopy   63 ( Suppl.1 )   949 - 949   2021年4月

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    記述言語:日本語  

  • Double scope recovery technique to manage procedure-related trouble during wire trimming with a Loop cutter. 国際誌

    Shuzaburo Nagatomo, Yosuke Minoda, Eikichi Ihara

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   33 ( 4 )   e83-e84   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.13954

  • Self-Completion Method of Endoscopic Submucosal Dissection Using Endosaber without Any Other Device or Assistance: An ex vivo Porcine Model Study. 国際誌

    Mitsuru Esaki, Yosuke Minoda, Masafumi Wada, Seiichiro Sakisaka, Shinichi Tsuruta, Taizo Hosokawa, Takahiro Matsuguchi, Ryoji Ichijima, Sho Suzuki, Yu Tamura, Aya Iwao, Shun Yamakawa, Akira Irie, Eikichi Ihara, Yoshihiro Ogawa

    Digestion   102 ( 2 )   139 - 146   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Endoscopic submucosal dissection (ESD) is a standard treatment for tumors of the gastrointestinal tract. We developed a self-completion method of ESD using Endosaber to eliminate the need for an additional device or human assistance during the procedure. The aim of this study was to evaluate the technical feasibility and outcomes of this method in an ex vivo porcine training model. METHODS: This was a pilot study, and the procedures were performed by 4 experts. Mock lesions measuring 15 mm in diameter were prepared at the posterior wall in the middle or lower esophagus obtained from domestic pigs. Each operator performed ESD on the mock lesions in 3 models. The primary outcome was ESD completion rate using the self-completion method. The secondary outcomes were procedure time, en bloc resection rate, perforation rate, and number of injections during the procedure. RESULTS: All 12 ESDs were completed using the self-completion method. The median procedure time (interquartile range) was 483.5 (399-619.3) s (median incision time: 240.4 [168.3-332.5] s; median dissection time: 222 [182.8-257] s). En bloc resection rate was 100%. No perforation was noted during any of the procedures. The median number of injections was 10.5 (9-14.3). The procedure time decreased significantly with increase in experience (p = 0.020). CONCLUSIONS: The self-completion ESD method using one Endosaber without any assistance achieved a 100% en bloc resection rate without any perforation. The need for an additional device or assistance was successfully eliminated. This method may prove to be a simple and cost-effective ESD procedure for lesions in humans.

    DOI: 10.1159/000502771

  • Assistant skill in gastric endoscopic submucosal dissection using a clutch cutter. 国際誌

    Mitsuru Esaki, Toshiki Horii, Ryoji Ichijima, Masafumi Wada, Seiichiro Sakisaka, Shuichi Abe, Naru Tomoeda, Yusuke Kitagawa, Kei Nishioka, Yosuke Minoda, Shinichi Tsuruta, Sho Suzuki, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa, Takuji Gotoda

    World journal of gastrointestinal surgery   13 ( 2 )   116 - 126   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: A clutch cutter is a scissor-type knife used in endoscopic submucosal dissection (ESD) for gastrointestinal tract tumors. The assistant during the ESD using a clutch cutter (ESD-C) needs to rotate the device and grasp the target tissue appropriately; therefore, the assistant's skill may affect the technical outcomes of ESD-C. AIM: To determine how assistant skill level affected the technical outcomes of gastric ESD-C using an ex vivo porcine training model. METHODS: In this pilot study, mock lesions of 15-30 mm in diameter were created in the middle or lower third of the porcine stomach. A total of 32 ESD-C procedures were performed by 16 trainees. Each trainee operator performed two ESD-C procedures; one ESD-C was assisted by an expert (ESD-C-E), and the other was assisted by a non-expert (ESD-C-NE). The total procedure time of the ESD was set as the primary outcome, and en bloc resection rate, complete procedure rate, perforation rate, and each procedure time/speed for mucosal incision or submucosal dissection were set as the secondary outcomes. In addition, we investigated factors associated with the difficulty of ESD including incompletion of ESD procedure, a long procedure time (≥ 20 min) or intraoperative perforation. RESULTS: The median total procedure time of the ESD-C-E was significantly shorter than that of the ESD-C-NE (12.9 min vs 21.9 min, P = 0.001). The en bloc resection rate was 100% in both groups. Complete resection rates of the ESD-C-E and ESD-C-NE groups were 100% and 93.8%, respectively. No intraoperative perforation was observed in both groups. In the multivariate analysis, assistant skill was significantly associated with the difficulty of ESD, with the highest odds ratio of 16.5. CONCLUSION: Assistance by an expert is an important factor when trainees perform ESD-C procedures.

    DOI: 10.4240/wjgs.v13.i2.116

  • Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula. 国際誌

    Nao Fujimori, Takashi Osoegawa, Akira Aso, Soichi Itaba, Yosuke Minoda, Masatoshi Murakami, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Takehiro Takaoka, Takamasa Oono, Eikichi Ihara, Tomoharu Yoshizumi, Takao Ohtsuka, Masafumi Nakamura, Yoshihiro Ogawa

    Canadian journal of gastroenterology & hepatology   2021   6691705 - 6691705   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Endoscopic ultrasound-guided transluminal drainage (EUS-TD) is generally performed 4 weeks after disease onset for evacuating pancreatic fluid collections. However, the optimal timing for conducting the procedure in those diagnosed with postoperative pancreatic fistula (POPF) has not been established. We aimed to elucidate the efficacy and safety of early EUS-TD procedures for treating POPF. Methods: We retrospectively reviewed patients diagnosed with POPF who underwent EUS-TD in the Kyushu University Hospital between 2008 and 2019. Clinical features were comparatively analyzed between the two patient groups who underwent either early (≤15 days postoperatively) or late (>15 days postoperatively) EUS-TD. Factors prolonging hospital stay were also analyzed using Cox proportional hazard models. Results: Thirty patients (median age, 64.5 years) were enrolled. The most common initial operation was distal pancreatectomy with splenectomy (60.0%). Median size of POPF was 69.5 (range, 38-145) mm, and median time interval between surgery and EUS-TD was 17.5 (range, 3-232) days. Totally, 47% patients underwent early EUS-TD. Rates of technical success, clinical success, and complications were 100%, 97%, and 6.9%, respectively. No recurrence of POPF occurred during a median follow-up period of 14 months. Clinical characteristics and outcomes were comparable between the early and late drainage patient groups, except for the rates of infection and nonencapsulation of POPF, which were significantly higher in the early drainage group. Performing simultaneous internal and external drainage (hazard ratio (HR): 0.31; 95% confidence interval (CI): 0.11-0.93, p=0.04) and conducting ≥2 treatment sessions (HR: 0.26; 95% CI: 0.08-0.84, p=0.02) were significantly associated with prolonged hospitalization after EUS-TD. Conclusions: EUS-TD is a safe and effective method for managing POPF, regardless of when it is performed in the postoperative period. Once infected POPF occurs, clinicians should not hesitate to perform EUS-TD even within 15 days of the initial operation.

    DOI: 10.1155/2021/6691705

  • 消化管粘膜下腫瘍に対する診断と治療の新展開 胃粘膜下腫瘍に対する粘膜切開生検の潜在的転移リスクと同手技による予後への影響

    蓑田 洋介, 板場 壮一, 隅田 頼信, 原口 和大, 麻生 暁, 水谷 孝弘, 小副川 敬, 松口 崇央, 江崎 充, 佐々木 泰介, 小森 圭司, 荻野 治栄, 伊原 栄吉

    日本消化管学会雑誌   5 ( Suppl. )   215 - 215   2021年1月

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    記述言語:日本語  

  • Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula 招待 査読 国際誌

    Fujimori N, Osoegawa T, Aso A, Itaba S, Minoda Y, Murakami M, Matsumoto K, Teramatsu K, Takamatsu Y, Takaoka T, Oono T, Ihara E, Yoshizumi T, Ohtsuka T, Nakamura M, Ogawa Y.

    2021年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors.

    Yosuke Minoda, Eikichi Ihara, Keishi Komori, Haruei Ogino, Yoshihiro Otsuka, Takatoshi Chinen, Yasuo Tsuda, Koji Ando, Hidetaka Yamamoto, Yoshihiro Ogawa

    Journal of gastroenterology   55 ( 12 )   1119 - 1126   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Although endoscopic ultrasound (EUS) is reported to be suitable for determining the layer from which subepithelial lesions (SELs) originate, it is difficult to distinguish gastrointestinal stromal tumor (GIST) from non-GIST using only EUS images. If artificial intelligence (AI) can be used for the diagnosis of SELs, it should provide several benefits, including objectivity, simplicity, and quickness. In this pilot study, we propose an AI diagnostic system for SELs and evaluate its efficacy. METHODS: Thirty sets each of EUS images with SELs ≥ 20 mm or < 20 mm were prepared for diagnosis by an EUS diagnostic system with AI (EUS-AI) and three EUS experts. The EUS-AI and EUS experts diagnosed the SELs using solely the EUS images. The concordance rates of the EUS-AI and EUS experts' diagnoses were compared with the pathological findings of the SELs. RESULTS: The accuracy, sensitivity, and specificity for SELs < 20 mm were 86.3, 86.3, and 62.5%, respectively for the EUS-AI, and 73.3, 68.2, and 87.5%, respectively, for the EUS experts. In contrast, accuracy, sensitivity, and specificity for SELs ≥ 20 mm were 90.0, 91.7, and 83.3%, respectively, for the EUS-AI, and 53.3, 50.0, and 83.3%, respectively, for the EUS experts. The area under the curve for the diagnostic yield of the EUS-AI for SELs ≥ 20 mm (0.965) was significantly higher than that (0.684) of the EUS experts (P = 0.007). CONCLUSION: EUS-AI had a good diagnostic yield for SELs ≥ 20 mm. EUS-AI has potential as a good option for the diagnosis of SELs.

    DOI: 10.1007/s00535-020-01725-4

  • Clutch Cutterを用いた食道ESDにおける助手の能力の影響(The influence of assistant skill in esophageal ESD using Clutch Cutter)

    江崎 充, 市島 諒二, 鈴木 翔, 草野 央, 池原 久朝, 和田 将史, 蓑田 洋介, 後藤田 卓志

    日本食道学会学術集会プログラム・抄録集   74回   108 - 108   2020年12月

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    記述言語:英語  

  • 食道疾患に対する治療法の進歩とその成績 内視鏡・胸腔鏡合同手術で切除し得た巨大食道平滑筋腫の2例

    水流 大尭, 畑 佳孝, 和田 将史, 蓑田 洋介, 小森 圭司, 田中 義将, 荻野 治栄, 伊原 栄吉

    日本消化器病学会九州支部例会プログラム・抄録集   116回   101 - 101   2020年12月

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    記述言語:日本語  

  • 胃・十二指腸腫瘍に対する低侵襲治療の現状と治療戦略 早期十二指腸腫瘍に対する治療前生検診断は有用か?

    蓑田 洋介, 友枝 成, 原口 和大, 赤星 和也, 板場 壮一, 麻生 曉, 荒殿 ちほ子, 北川 祐介, 原田 直彦, 富田 洋介, 久保川 賢, 荻野 治栄, 伊原 栄吉

    日本消化器病学会九州支部例会プログラム・抄録集   116回   77 - 77   2020年12月

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    記述言語:日本語  

  • Ex vivo porcine model study on the treatment outcomes of scissor-type knife versus needle-type knife in endoscopic submucosal dissection performed by trainees. 国際誌

    Ryoji Ichijima, Mitsuru Esaki, Shun Yamakawa, Yosuke Minoda, Sho Suzuki, Chika Kusano, Hisatomo Ikehara, Takuji Gotoda

    BMC surgery   20 ( 1 )   287 - 287   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Endoscopic submucosal dissection (ESD) for gastrointestinal neoplasms can be technically difficult for trainee endoscopists. Presently, there is no consensus for trainees to select the endo-knife type in ESD. Therefore, we conducted a comparison study of treatment outcomes between scissors-type and needle-type knives in ESD performed by trainees in an ex vivo porcine model. METHODS: This study was conducted on trainee endoscopists who participated in ESD hands-on seminars held in August 2018 and September 2019. A total of 22 trainees from 13 institutions were divided into two groups according to their endoscopic experience. Under expert supervision, each trainee performed two ESDs in porcine models, namely, scissor-type knife (ESD-S) and needle-type knife (ESD-N). The efficacy and safety, including the procedure time and rates of self-completion, en bloc resection, and complications, were compared between ESD-S and ESD-N. In subgroup analysis, we also investigated the predictors associated with the difficulty of ESD for trainees using multivariate logistic regression analysis. RESULTS: Eight trainees had an experience of over 1000 endoscopies (senior trainee: S-Trainee), whereas the others had an experience of less than 1000 endoscopies (junior trainee: J-Trainee). Among the S-Trainees, no significant differences were observed in any treatment outcome between ESD-S and ESD-N. Among the J-Trainees, the total procedure and mucosal incision times were significantly shorter in ESD-S than in ESD-N [total procedure time: 16.5 min (range 10.0-31.0) vs. 22.3 min (range 10.0-38.0), P = 0.018; circumferential incision time: 10.0 min (range 6-16) vs. 17.0 min (range 5.0-31.5); P = 0.019]. Regarding complications, muscular injury occurred in two patients during ESD-N performed by J-Trainees; however, no muscular injury occurred during ESD-S. In subgroup analysis, ESD-N was an independent predictive factor of difficult ESD (odds ratio 5.28, 95% confidence interval 1.25-22.30; P = 0.024). CONCLUSIONS: This study revealed that trainees, particularly those who have experienced less than 1000 endoscopies, should opt for the scissor-type knife to perform ESD.

    DOI: 10.1186/s12893-020-00955-w

  • 胃粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断の有用性

    蓑田 洋介, 荻野 治栄, 伊原 栄吉

    日本消化器病学会雑誌   117 ( 臨増大会 )   A699 - A699   2020年10月

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    記述言語:日本語  

  • AIを用いた次世代の内視鏡診療 胃粘膜下腫瘍に対する人工知能を用いた超音波内視鏡画像診断能の検討

    蓑田 洋介, 荻野 治栄, 伊原 栄吉

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1126 - 1126   2020年8月

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    記述言語:日本語  

  • Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors. 国際誌

    Mitsuru Esaki, Kazuhiro Haraguchi, Kazuya Akahoshi, Naru Tomoeda, Akira Aso, Soichi Itaba, Haruei Ogino, Yusuke Kitagawa, Hiroyuki Fujii, Kazuhiko Nakamura, Masaru Kubokawa, Naohiko Harada, Yosuke Minoda, Sho Suzuki, Eikichi Ihara, Yoshihiro Ogawa

    World journal of gastrointestinal oncology   12 ( 8 )   918 - 930   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors (SNADETs) is controversial. AIM: To compare the efficacy and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for SNADETs. METHODS: We retrospectively analyzed the data of patients with SNADETs from a database of endoscopic treatment for SNADETs, which included eight hospitals in Fukuoka, Japan, between April 2001 and October 2017. A total of 142 patients with SNADETs treated with EMR or ESD were analyzed. Propensity score matching was performed to adjust for the differences in the patient characteristics between the two groups. We analyzed the treatment outcomes, including the rates of en bloc/complete resection, procedure time, adverse event rate, hospital stay, and local or metastatic recurrence. RESULTS: Twenty-eight pairs of patients were created. The characteristics of patients between the two groups were similar after matching. The EMR group had a significantly shorter procedure time and hospital stay than those of the ESD group [median procedure time (interquartile range): 6 (3-10.75) min vs 87.5 (68.5-136.5) min, P < 0.001, hospital stay: 8 (6-10.75) d vs 11 (8.25-14.75) d, P = 0.006]. Other outcomes were not significantly different between the two groups (en bloc resection rate: 82.1% vs 92.9%, P = 0.42; complete resection rate: 71.4% vs 89.3%, P = 0.18; and adverse event rate: 3.6% vs 17.9%, P = 0.19, local recurrence rate: 3.6% vs 0%, P = 1; metastatic recurrence rate: 0% in both). Only one patient in the ESD group underwent emergency surgery owing to intraoperative perforation. CONCLUSION: EMR has significantly shorter procedure time and hospital stay than ESD, and provides acceptable curability and safety compared to ESD. Accordingly, EMR for SNADETs is associated with lower medical costs.

    DOI: 10.4251/wjgo.v12.i8.918

  • 消化器病における若手医師のトレーニング 若手医師に対する2年間の超音波内視鏡トレーニングプログラムの有用性

    蓑田 洋介, 藤森 尚, 小副川 敬, 麻生 暁, 荻野 治栄, 大野 隆真, 伊原 栄吉

    日本消化器病学会九州支部例会プログラム・抄録集   115回   96 - 96   2020年6月

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    記述言語:日本語  

  • 消化管粘膜下腫瘍における治療戦略 胃粘膜下腫瘍に対する外科的治療の現状と課題

    胡 慶江, 津田 康雄, 宮下 優, 酒井 陽玄, 古賀 直道, 栗山 直剛, 野中 謙太朗, 家守 智大, 藤本 禎明, 春田 泰宏, 財津 瑛子, 久松 雄一, 安藤 幸滋, 中島 雄一郎, 木村 和恵, 蓑田 洋介, 伊原 栄吉, 小田 義直, 沖 英次, 森 正樹

    日本消化器病学会九州支部例会プログラム・抄録集   115回   92 - 92   2020年6月

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    記述言語:日本語  

  • 消化管粘膜下腫瘍における治療戦略 胃粘膜下腫瘍に対する腹腔鏡内視鏡合同手術(LECS)の導入

    津田 康雄, 沖 英次, 宮下 優, 酒井 陽玄, 古賀 直道, 栗山 直剛, 野中 謙太朗, 家守 智大, 藤本 禎明, 春田 泰宏, 胡 慶江, 財津 瑛子, 久松 雄一, 安藤 幸滋, 中島 雄一郎, 木村 和恵, 蓑田 洋介, 伊原 栄吉, 小田 義直, 森 正樹

    日本消化器病学会九州支部例会プログラム・抄録集   115回   92 - 92   2020年6月

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    記述言語:日本語  

  • 消化管粘膜下腫瘍における治療戦略 胃粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断能の検討

    蓑田 洋介, 小森 圭司, 西岡 慧, 和田 将史, 畑 佳孝, 大塚 宜寛, 長友 周三郎, 水流 大尭, 竹島 翼, 丸山 薫, 荻野 治栄, 津田 康雄, 沖 英次, 伊原 栄吉

    日本消化器病学会九州支部例会プログラム・抄録集   115回   91 - 91   2020年6月

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    記述言語:日本語  

  • Endoscopy-guided suction method for residual food in the stomach caused by the obstruction of a duodenal stent. 国際誌

    Yosuke Minoda, Keishi Komori, Nao Fujimori

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   32 ( 4 )   e69-e70   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.13637

  • The effect of scissor-type versus non-scissor-type knives on the technical outcomes in endoscopic submucosal dissection for superficial esophageal cancer: a multi-center retrospective study. 国際誌

    Mitsuru Esaki, Yasuyo Hayashi, Hisatomo Ikehara, Eikichi Ihara, Toshiki Horii, Yu Tamura, Ryoji Ichijima, Shun Yamakawa, Akira Irie, Hitoshi Shibuya, Sho Suzuki, Chika Kusano, Yosuke Minoda, Hirotada Akiho, Yoshihiro Ogawa, Takuji Gotoda

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   33 ( 4 )   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The Clutch Cutter was invented as a scissor-type knife for endoscopic submucosal dissection (ESD) of gastrointestinal neoplasms. ESD with the scissor-type knife (ESD-S) may be considered a technically easier procedure than ESD with non-scissor-type knives (ESD-NS). Therefore, this study aimed to compare the technical outcomes of ESD-S with those of ESD-NS for superficial esophageal cancer. This was a multicenter retrospective study. Patients with superficial esophageal cancer treated with ESD between October 2015 and March 2018 at three hospitals were retrospectively reviewed. The ESD-S group had 48 patients and the ESD-NS group had 114 patients. A propensity score matching analysis was performed to compensate for the confounding bias between both groups. Multivariate analyses and propensity score matching were used to adjust for age, sex, the tumor size, tumor location, tumor depth, degree of tumor circumference, operator level, usage of the traction method, and the sedation method. The primary outcome was the procedure time of the ESD. Secondary outcomes were the rate of en-bloc/complete resection and the rate of complications including perforation, delayed bleeding, and stricture. Propensity score matching analysis provided 36 matched pairs. Median procedure time in the ESD-S group was significantly shorter than that in the ESD-NS group (44.0 min vs. 66.5 min, P = 0.020). In addition, the treatment outcomes were similar in both groups (en-bloc resection: 100% vs. 97.2%, P = 1; complete resection: 88.9% vs. 86.1%, P = 1; curative resection: 80.6% vs. 77.8%, P = 1; perforation: 0% vs. 5.6%, P = 0.49; delayed bleeding: 0% in both groups; stricture: 2.8% vs. 8.3%, P = 0.61). ESD-S was associated with a shorter procedure time than ESD-NS, without an increase in the incidence of complications. Therefore, the scissor-type knife should be considered as an endo-knife for ESD of superficial esophageal cancers.

    DOI: 10.1093/dote/doz077

  • The Efficacy and Safety of a Promising Single-Channel Endoscopic Closure Technique for Endoscopic Treatment-Related Artificial Ulcers: A Pilot Study. 国際誌

    Yosuke Minoda, Eikichi Ihara, Haruei Ogino, Keishi Komori, Yoshihiro Otsuka, Hiroko Ikeda, Mitsuru Esaki, Takatoshi Chinen, Takahiro Matsuguchi, Shunsuke Takahashi, Noriko Shiga, Rie Yoshimura, Yoshihiro Ogawa

    Gastrointestinal tumors   7 ( 1-2 )   21 - 29   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background/Aims: It is important to appropriately manage patients with procedure-related artificial mucosal ulcers or procedure-related complications. Many endoscopic closure techniques have been reported; however, they often require the use of special devices. We developed a single-channel endoscopic closure technique (SCCT) that can be performed with conventional devices. In the present study, we describe the technique and evaluate its efficacy. Methods: Twenty-five consecutive patients who underwent endoscopic treatment and whose artificial ulcer was closed using the SCCT were enrolled in this study. The technical success rate, number of clips for closure, procedure time, complication rate on the day of the procedure, clinical success rates on days 1 and 5, and incidence of severe stenosis of the gastrointestinal (GI) tract at 2 months after the procedure were evaluated. Results: The median ulcer diameter was 20 mm. The tumor locations were the stomach (n = 19), jejunum (n = 1), and colon (n = 5). The technical success rate was 100% (25/25), and the rate of incomplete closure was 0% (0/25). Eight clips were needed on average. The median procedure time was 18 min (range 5-49 min). The complication rate was 0% (25/25). The clinical success rates on days 1 and 5 were 100% (19/19) and 100% (9/9), respectively. No patients presented stenosis as a late complication at 2 months after the procedure (0/25). Conclusion: The SCCT could be applied in the treatment of artificial ulcers in several parts of the GI tract with a high clinical success rate and no complications. The SCCT appears to be a good option for closing artificial mucosal ulcers.

    DOI: 10.1159/000503994

  • Endoscopic removal of a lumen-apposing metal stent that migrated into the walled-off necrosis during the first drainage procedure. 国際誌

    Nao Fujimori, Yosuke Minoda, Masatoshi Murakami, Yuta Suehiro, Takamasa Oono, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   52 ( 2 )   E51-E52   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-0992-8900

  • Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: a propensity score matching analysis. 国際誌

    Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    BMC gastroenterology   20 ( 1 )   19 - 19   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the gold standard for diagnosing gastric subepithelial lesions, alternative open biopsy procedures, such as mucosal incision-assisted biopsy (MIAB) has been reported useful. The aim of this study is to evaluate the efficacy of MIAB for the diagnosis of gastric SELs compared with EUS-FNAB. METHODS: We retrospectively analyzed medical records of 177 consecutive patients with gastric SELs who underwent either MIAB or EUS-FNAB at five hospitals in Japan between January 2010 and January 2018. Diagnostic yield, procedural time, and adverse event rates for the two procedures were evaluated before and after propensity-score matching. RESULTS: No major procedure-related adverse events were observed in either group. Both procedures yielded highly-accurate diagnoses once large enough samples were obtained; however, such successful sampling was more often accomplished by MIAB than by EUS-FNAB, especially for small SELs. As a result, MIAB provided better diagnostic yields for SELs smaller than 20-mm diameter. The diagnostic yields of both procedures were comparable for SELs larger than 20-mm diameter; however, MIAB required significantly longer procedural time (approximately 13 min) compared with EUS-FNAB. CONCLUSIONS: Although MIAB required longer procedural time, it outperformed EUS-FNAB when diagnosing gastric SELs smaller than 20-mm diameter.

    DOI: 10.1186/s12876-020-1170-2

  • Efficacy of traction, using a clip-with-thread, for esophageal endoscopic submucosal dissection for esophageal lesions with fibrosis in an ex vivo pig training model. 国際誌

    Mitsuru Esaki, Yosuke Minoda, Eikichi Ihara, Seiichiro Sakisaka, Shinichi Tsuruta, Taizo Hosokawa, Masafumi Wada, Yoshitaka Hata, Sho Suzuki, Aya Iwao, Shun Yamakawa, Akira Irie, Hirotada Akiho, Yoshihiro Ogawa

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology   31 ( 1 )   58 - 64   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) of recurrent esophageal carcinoma is technically difficult to perform due to submucosal fibrosis that develops after definitive chemoradiation therapy. Therefore, our aim was to evaluate the usefulness of clip-with-thread traction for ESD of esophageal lesions with submucosal fibrosis. MATERIALS AND METHODS: Four endoscopists excised 16 lesions by ESD in an ex vivo pig training model. Mock lesions (30 mm in diameter) were created, including a 10-mm area of submucosal fibrosis in the center of each lesion. Each endoscopist performed two ESDs with traction (ESD-T) and two without traction (ESD-N). The primary outcome was the time required for submucosal dissection. Secondary outcomes were the rate of en bloc (complete) resection and perforation during the procedure, and the total amount of solution injected. RESULTS: All esophageal ESDs were completed. The median dissection time was significantly shorter for the ESD-T group (median 12.5 min, interquartile range 10.2-14.5) when comparing to the ESD-N group (median 18.0 min, interquartile range 14.6-19.2) (P=0.040). The en bloc resection rate was 100% in both groups, with a rate of complete resection of 87.5% and a rate of perforation of 37.5% for both groups. The median amount of solution injected was not significantly different between the ESD-T (18.0 ml) and ESD-N (20.5 ml) groups (P=0.526). CONCLUSION: Clip-with-thread traction improved the performance of ESD for lesions with submucosal fibrosis. However, the method might not reduce the risk of perforation, which remains an important clinical issue to resolve.

    DOI: 10.5152/tjg.2020.19207

  • The Altered Mucosal Barrier Function in the Duodenum Plays a Role in the Pathogenesis of Functional Dyspepsia. 国際誌

    Keishi Komori, Eikichi Ihara, Yosuke Minoda, Haruei Ogino, Taisuke Sasaki, Minako Fujiwara, Yoshinao Oda, Yoshihiro Ogawa

    Digestive diseases and sciences   64 ( 11 )   3228 - 3239   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: An altered gastrointestinal barrier function is reportedly associated with the pathogenesis of functional dyspepsia (FD); however, the pathogenesis of FD has not yet been fully elucidated. AIMS: The objective of the present study was to determine whether the mucosal barrier function is impaired in patients with FD and to investigate the mechanisms underlying FD. METHODS: The present study included patients with FD (FD group, n = 24), non-FD patients with abdominal symptoms (symptomatic control group, n = 14), and patients with no abdominal symptoms (asymptomatic control group, n = 20). The groups were compared regarding the mucosal electrical impedance (MI) values of the stomach and duodenum, which were measured using a tissue conductance meter during esophagogastroduodenoscopy. RESULTS: There were no significant differences between the three groups in the MI of the stomach. In contrast, the duodenal MI of the FD group (17.8 ± 4.3 Ω) was significantly lower than those of the symptomatic control group (27.2 ± 6.4 Ω, p < 0.0001) and asymptomatic control group (23.0 ± 7.4 Ω, p = 0.016). The expression of zonula occludens-1 (ZO-1) was significantly lower in the FD group than in the symptomatic control group (p = 0.011), where ZO-1 was positively correlated with the duodenal MI (β = 0.513, p = 0.017). The interleukin (IL)-1β expression was significantly higher in the FD group than in the symptomatic control group (p = 0.041), where IL-1β was inversely correlated with the duodenal MI (β = - 0.600, p = 0.004). CONCLUSIONS: The mucosal barrier function of the duodenum was altered in patients with FD. Both a decreased ZO-1 and increased IL-1β may play a role in the pathogenesis of FD.

    DOI: 10.1007/s10620-019-5470-8

  • Forward-viewing endoscopic ultrasound-guided fine-needle biopsy using the clip-with-thread method for small gastric subepithelial lesions. 国際誌

    Yosuke Minoda, Nao Fujimori, Eikichi Ihara

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 6 )   e103-e104   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.13476

  • 【膵炎大全II~膵炎・Up to date~】膵の発生と形成異常 コラム 異所性膵

    蓑田 洋介, 小森 圭司, 荻野 治栄, 伊原 栄吉, 木下 展克, 大野 隆真, 小田 義直, 小川 佳宏

    胆と膵   40 ( 臨増特大 )   1057 - 1060   2019年11月

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    記述言語:日本語  

    異所性膵(heterotopic pancreas)は本来の膵臓とは連続性をもたず、血行支配も異なる他臓器に存在する膵組織のことで、大半の異所性膵は無症状で経過することが多い。消化管管腔内に発生する場合、ときに、サイズが増大し閉塞を起こす症例や出血を伴うもの、癌化を伴うものもあり、胃部不快感や痛み症状が出現することもある。その診断は通常光内視鏡での粘膜下腫瘍の確認ならびに超音波内視鏡検査での内部性状、病理学的評価が有用とされているが、超音波内視鏡下吸引穿刺細胞診(EUS-FNAB)でも診断率は十分とは言えず、診断に苦慮する症例も存在する。癌化が疑われる症例、腫瘍径が30mm以上と大きいもの、急速にサイズが増大するものは悪性の可能性があるとされ外科的加療を考慮する必要があるものの、良性例での増大もあり必ずしも悪性とは言えないことに注意が必要である。(著者抄録)

  • Objective validity of the Japan Narrow-Band Imaging Expert Team classification system for the differential diagnosis of colorectal polyps. 国際誌

    Yosuke Minoda, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Kazuhiro Haraguchi, Hirotada Akiho, Nobuyoshi Takizawa, Akira Aso, Yosuke Tomita, Mitsuru Esaki, Keishi Komori, Yoshihiro Otsuka, Tsutomu Iwasa, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 5 )   544 - 551   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIM: The Japan Narrow-Band Imaging (NBI) Expert Team (JNET) classification is a recently proposed NBI magnifying endoscopy-based classification system for colorectal tumors. Although the usefulness of this system has been reported by JNET experts, its objective validity remains unclear. We tested its validity and usefulness for the diagnosis of colorectal polyps by including colonoscopy experts and non-experts as test participants. METHODS: Forty NBI images of polyps of various JNET types were shown to 22 doctors (11 experts and 11 non-gastrointestinal [GI] trainees) who had not examined the patients. The doctors diagnosed the polyps based solely on the surface and vessel patterns in the magnified images and the JNET classification system. Concordance rates of their diagnoses with the pathological findings of the polyps were determined, and the results for experts and non-GI trainees were compared. RESULTS: Both for colonoscopy experts and non-GI trainees, the JNET classification system was particularly useful for classifying polyps as benign or malignant. Although the accuracy rates for classifying polyps into each JNET type varied among colonoscopy experts, those who were familiar with the JNET classification system were able to diagnose polyps with approximately 90% accuracy. Common mistakes were attributable to misunderstandings of the wording in the JNET classification chart and lack of proper training. CONCLUSION: The JNET classification system is a practical approach for the diagnosis of colorectal polyps. Training is required even for experienced colonoscopists to adopt the system properly. Common pitfalls must be shared among colonoscopists to improve the accuracy of the diagnosis.

    DOI: 10.1111/den.13393

  • Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions: A randomized cross-over study. 国際誌

    Takashi Osoegawa, Yosuke Minoda, Eikichi Ihara, Keishi Komori, Akira Aso, Ayako Goto, Soichi Itaba, Haruei Ogino, Kazuhiko Nakamura, Naohiko Harada, Kosuke Makihara, Shinichi Tsuruta, Hidetaka Yamamoto, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 4 )   413 - 421   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: This study aimed to compare the diagnostic yield of mucosal incision-assisted biopsy (MIAB) and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with a rapid on-site evaluation (ROSE) for gastric subepithelial lesions (SEL) suspected of being gastrointestinal stromal tumors (GIST) with an intraluminal growth pattern. METHODS: This was a prospective randomized, cross-over multicenter study. The primary outcome was the diagnostic yield of EUS-FNA and MIAB. The secondary outcomes were the technical success rate, complication rate, procedure time and biopsy frequency. RESULTS: A total of 47 patients were randomized to the MIAB group (n = 23) and EUS-FNA group (n = 24). There was no significant difference in the diagnostic yield of MIAB and EUS-FNA (91.3% vs 70.8%, P = 0.0746). The complication rates of MIAB and EUS-FNA did not differ to a statistically significant extent. The mean procedure time in the MIAB group was significantly longer than that in the EUS-FNA group (34 vs 26 min, P = 0.0011). CONCLUSIONS: The diagnostic yield of MIAB was satisfactorily as high as EUS-FNA with ROSE for gastric SEL with an intraluminal growth pattern.

    DOI: 10.1111/den.13367

  • 胃GISTと鑑別を要した胃迷入膵の1例

    田中 貴英, 平野 敦士, 蓑田 洋介, 岡本 康治, 冬野 雄太, 藤岡 審, 梅野 淳嗣, 鳥巣 剛弘, 森山 智彦, 保利 喜史, 藤原 美奈子, 北園 孝成

    日本消化器病学会九州支部例会プログラム・抄録集   113回   136 - 136   2019年5月

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    記述言語:日本語  

  • 消化管生理機能検査法の発展:方法論から機能性消化管疾患研究を切り拓く 機能性ディスペプシアにおける消化管粘膜バリア機能評価

    小森 圭司, 伊原 栄吉, 荻野 治栄, 蓑田 洋介, 小川 佳宏

    日本消化管学会雑誌   3 ( Suppl. )   218 - 218   2019年2月

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    記述言語:日本語  

  • Clutch Cutter knife efficacy in endoscopic submucosal dissection for early gastric neoplasms. 国際誌

    Yasuyo Hayashi, Mitsuru Esaki, Sho Suzuki, Eikichi Ihara, Azusa Yokoyama, Seiichiro Sakisaka, Taizo Hosokawa, Yoshimasa Tanaka, Takahiro Mizutani, Shinichi Tsuruta, Aya Iwao, Shun Yamakawa, Akira Irie, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Yoshihiro Ogawa

    World journal of gastrointestinal oncology   10 ( 12 )   487 - 495   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: To compare the outcomes of endoscopic submucosal dissection (ESD) for gastric neoplasms using Clutch Cutter (ESD-C) or other knives (ESD-O). METHODS: This was a single-center retrospective study. Gastric neoplasms treated by ESD between April 2016 and October 2017 at Kitakyushu Municipal Medical Center were reviewed. Multivariate analyses and propensity score matching were used to reduce biases. Covariates included factors that might affect outcomes of ESD, including age, sex, underlying disease, anti-thrombotic drugs use, tumor location, tumor position, tumor size, tumor depth, tumor morphology, tumor histology, ulcer (scar), and operator skill. The treatment outcomes were compared among two groups. The primary outcome was ESD procedure time. Secondary outcomes were en bloc, complete, and curative resection rates, and adverse events rates including perforation and delayed bleeding. RESULTS: A total of 155 patients were included in this study; 44 pairs were created by propensity score matching. Background characteristics were quite similar among two groups after matching. Procedure time was significantly shorter for ESD-C (median; 49 min) than for ESD-O (median; 88.5 min) (P < 0.01). However, there was no significant difference in treatment outcomes between ESD-C and ESD-O including en bloc resection rate (100% in both groups), complete resection rate (100% in both groups), curative resection rate (86.4% vs 88.6%, P = 0.730), delayed bleeding (2.3% vs 6.8%, P = 0.62) and perforation (0% in both groups). CONCLUSION: ESD-C achieved shorter procedure time without an increase in complication risk. Therefore, ESD-C could become an effective ESD option for gastric neoplasms.

    DOI: 10.4251/wjgo.v10.i12.487

  • 十二指腸粘膜下腫瘍に対するwater assisted EUS-FNAの経験 従来法との比較

    麻生 暁, 蓑田 洋介, 小森 圭司, 後藤 綾子, 荻野 治栄, 鶴田 伸一, 小田 義直, 秋穂 裕唯, 伊原 栄吉

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2098 - 2098   2018年10月

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    記述言語:日本語  

  • 機能性消化管疾患-本邦の現状と最近の進歩- 機能性ディスペプシアにおける消化管粘膜バリア機能評価

    小森 圭司, 伊原 栄吉, 荻野 治栄, 蓑田 洋介, 小川 佳宏

    日本臨床生理学会雑誌   48 ( 4 )   60 - 60   2018年10月

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    記述言語:日本語  

  • Recovery technique using a double scope to rescue failed primary endoscopic ligation. 国際誌

    Yosuke Minoda, Keishi Komori, Ryoko Naruo, Tsutomu Iwasa, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   50 ( 9 )   E244-E245   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-0631-7760

  • Propensity score-matching analysis to compare clinical outcomes of endoscopic submucosal dissection for early gastric cancer in the postoperative and non-operative stomachs. 国際誌

    Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Shinichi Tsuruta, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa

    BMC gastroenterology   18 ( 1 )   125 - 125   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Endoscopic submucosal dissection (ESD) of the postoperative stomach (ESD-P) for early gastric cancer (EGC) is considered a technically difficult procedure. However, it is difficult to compare the outcomes of ESD-P and ESD of the non-operative stomach (ESD-N) because their baseline characteristics are different. Therefore, we aimed to compare the technical outcomes of ESD-P with those of ESD-N using a propensity score-matching analysis to compensate for the differences. METHODS: The chart records of 1046 patients with EGC who were treated with ESD between January 2004 and July 2016 at Kitakyushu Municipal Medical Center in Japan were reviewed in this retrospective study. Multivariate analyses and propensity score-matching were performed for age, sex, lesion location, lesion size, tumor invasion, tumor size, ulcer (scar), and operator skill. The primary outcome was procedure time. Secondary outcomes were percentages of en bloc, complete, and curative resections, and percentages of adverse events, which were evaluated between the two groups. RESULTS: Forty-one patients were in the ESD-P group and 1005 patients were in the ESD-N group. Propensity score-matching created 41 matched pairs. According to the adjusted comparisons, ESD-P required a significantly longer procedure time (85 min vs 51 min, p < 0.001). Other treatment outcomes showed an en bloc resection rate of 100% for both groups (p = 1) and complete resection rates of 95.1 and 97.6% (p = 1), curative resection rates of 90.2 and 90.2% (p = 1), perforation during ESD rates of 2.4 and 0% (p = 1), and postprocedure bleeding rates of 2.4 and 2.4% (p = 1) for the ESD-P and ESD-N groups, respectively. For the ESD-P group, lesions on the suture line or anastomotic site were significantly associated with longer procedure times (p = 0.038). CONCLUSIONS: ESD-P was a more time-consuming procedure than ESD-N. However, ESD-P and ESD-N achieved high rates of curative resection with a low rate of adverse events for the treatment of EGC. ESD could be selected as the treatment for EGC even in the postoperative stomach provided that careful attention is given to lesions on the suture line or anastomotic site.

    DOI: 10.1186/s12876-018-0855-2

  • Intrapancreatic recurrence of intraductal tubulopapillary neoplasm (ITPN) 16 years after the initial surgery for noninvasive ITPN: a case report. 国際誌

    Kiyoshi Saeki, Yoshihiro Miyasaka, Yoshihiro Ohishi, Takeo Yamamoto, Ryota Matsuda, Naoki Mochidome, Yasuhisa Mori, Kohei Nakata, Takao Ohtsuka, Kousei Ishigami, Yosuke Minoda, Yutaka Koga, Yoshinao Oda, Masafumi Nakamura

    Surgical case reports   4 ( 1 )   96 - 96   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Intraductal tubulopapillary neoplasm (ITPN) is a rare pancreatic intraductal neoplasm. It is characterized by a tubulopapillary growth pattern, entirely high-grade atypical cells, minimal cytoplasmic mucin, and no obvious luminal mucin secretion. Most of its biological nature remains unclear. CASE PRESENTATION: We herein report a case of intrapancreatic recurrence of ITPN in the remnant pancreas of a patient who underwent pancreatoduodenectomy 16 years previously for a noninvasive intraductal pancreatic head tumor. We reexamined the primary tumor and compared it with the most recently resected specimen. Histologically, the primary tumor showed a tubulopapillary growth of high-grade atypical cells with scanty cytoplasmic mucin, which was similar to the recently resected specimen except for the invasive area. Immunohistochemically, the neoplastic cells in both specimens showed focal staining of MUC1 and positivity for MUC6 but negativity for MUC2, MUC5AC, CDX2, and trypsin. Molecular analysis revealed no KRAS/GNAS/BRAF/PIK3CA mutations in either of the specimens. CONCLUSIONS: These findings of the original tumor and recently resected tumor were compatible with the features of ITPN. Thus, recurrence is possible even for a primary noninvasive ITPN, and long-term surveillance is recommended.

    DOI: 10.1186/s40792-018-0497-1

  • 消化管粘膜バリア機能評価は、機能性ディスペプシアの診断に有用である

    小森 圭司, 伊原 栄吉, 荻野 治栄, 蓑田 洋介, 西原 佑一郎, 小川 佳宏

    日本内科学会雑誌   107 ( Suppl. )   192 - 192   2018年2月

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    記述言語:日本語  

  • Endoscopic submucosal dissection of early duodenal tumor using the Clutch Cutter: a preliminary clinical study. 国際誌

    Yosuke Minoda, Kazuya Akahoshi, Yoshihiro Otsuka, Masaru Kubokawa, Yasuaki Motomura, Masafumi Oya, Kazuhiko Nakamura

    Endoscopy   47 Suppl 1 UCTN   E267-8   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/s-0034-1392209

  • [Synchronous gastrointestinal stromal tumors of the rectum and duodenum: a case report].

    Yosuke Minoda, Soichi Itaba, Toyoma Kaku, Kosuke Makihara, Junko Matsuoka, Hiroyuki Murao, Tetsuo Hamada, Kazuhiko Nakamura

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   112 ( 11 )   1991 - 7   2015年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    An 85-year-old woman with anemia underwent colonoscopy, which revealed a 25-mm submucosal tumor with ulceration in the lower rectum. Histological examination of a biopsy showed that the lesion was a gastrointestinal stromal tumor (GIST). Subsequent esophagogastroduodenoscopy revealed a submucosal tumor in the duodenum, and examination of a biopsy obtained by endoscopic ultrasound-guided fine-needle aspiration also confirmed that this lesion was a GIST. The rectal lesion was surgically resected to control bleeding and was confirmed as a GIST histologically. Simultaneous development of GISTs in the rectum and duodenum is extremely rare.

    DOI: 10.11405/nisshoshi.112.1991

  • [Three cases of pedunculated gastric hamartomatous inverted polyps resected endoscopically].

    Junko Matsuoka, Soichi Itaba, Yasuaki Makihara, Hiroyuki Murao, Naruhiro Umeno, Yosuke Minoda, Toyoma Kaku, Masami Kuniyoshi, Tetsuo Hamada, Kazuhiko Nakamura

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   112 ( 6 )   1030 - 6   2015年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    We report three cases of pedunculated gastric hamartomatous inverted polyps (HIPs) that were successfully treated by endoscopic polypectomy. The first case involved an 87-year-old woman with mild anemia. Esophagogastroduodenoscopy (EGD) revealed a pedunculated, reddish polyp located at the greater curvature of the upper stomach. The second case involved a 34-year-old woman in whom a pedunculated polyp was found at the gastric fundus during routine EGD. The third patient was a 59-year-old woman with epigastric discomfort. EGD revealed a pedunculated polyp in the gastric fundus. Polypectomy was successfully performed in all three cases. Histological examination revealed that the tumors comprised submucosal proliferation of cystically dilated gastric glands and hyperplastic glands;thus, we diagnosed gastric HIPs, which are rare and typically difficult to diagnose. Gastric HIPs should be considered in the differential diagnosis of elevated gastric lesions.

    DOI: 10.11405/nisshoshi.112.1030

  • Gastric intramural hematoma caused by endoscopic ultrasound-guided fine-needle biopsy. 国際誌

    Soichi Itaba, Toyoma Kaku, Yosuke Minoda, Hiroyuki Murao, Kazuhiko Nakamura

    Endoscopy   46 Suppl 1 UCTN   E666   2014年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/s-0034-1390867

  • Gastric glomus tumor diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy: report of a case.

    Yosuke Minoda, Kazuya Akahoshi, Masafumi Oya, Masaru Kubokawa, Yasuaki Motomura, Kazuhiko Nakamura

    Fukuoka igaku zasshi = Hukuoka acta medica   105 ( 4 )   105 - 9   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A glomus tumor of the stomach is rare. It is difficult to diagnose the tumor before surgery by only endoscopic biopsy and radiography, and there is no established method of diagnosis before surgical treatment. Esophagogastroduodenoscopy (EGD) on a 50-year-old Japanese woman revealed a 10 mm submucosal tumor in the anterior wall of the gastric angle. Follow-up EGD revealed an increase in the size of the tumor to 15mm. Endoscopic ultrasonography (EUS) demonstrated a 15mm subepithelial hypoechoic solid tumor with continuity to the proper muscle layer. Histologic diagnosis by endoscopic ultrasonography guided fine needle aspiration (EUS-FNA) was glomus tumor. The tumor was treated by laparoscopic local resection. The histologic diagnosis of the resected tumor was similar to the preoperative EUS-FNA results. EUS-FNA would appear to be an effective histologic test for early diagnosis of gastric glomus tumor.

  • Endoscopic submucosal dissection using the "Clutch Cutter" for early esophageal squamous cell carcinoma. 国際誌

    Kazuya Akahoshi, Yousuke Minoda, Keishi Komori, Yasuaki Motomura, Masaru Kubokawa, Yoshihiro Otsuka, Syouhei Hamada, Shinichirou Fukuda, Risa Iwao, Junya Gibo, Masafumi Oya, Kazuhiko Nakamura

    Endoscopy   45 ( 12 )   1035 - 8   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND STUDY AIMS: To reduce the risk of complications related to the use of knives in endoscopic submucosal dissection (ESD), we developed the Clutch Cutter which can grasp and incise targeted tissue using electrosurgical current, similarly to a biopsy technique. The study aim was to evaluate the efficacy and safety of ESD using the Clutch Cutter for early esophageal squamous cell carcinoma. PATIENTS AND METHODS: ESD using the Clutch Cutter was performed on 32 consecutive patients with early esophageal squamous cell carcinoma. Therapeutic efficacy and safety were assessed. RESULTS: All lesions were treated easily and safely without unintended incision. En bloc resection was obtained in all patients. Histologically negative margins were obtained in 26/32 patients (81%). Endoscopic perforation due to the hood in one patient (3%), mediastinitis without endoscopic perforation in one patient (3%), and post-ESD stricture in 5 patients (16%) were observed. All were successfully managed conservatively. CONCLUSIONS: ESD using the Clutch Cutter appears to be a safe, easy, and technically efficient method for resecting early esophageal squamous cell carcinomas.

    DOI: 10.1055/s-0033-1344863

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書籍等出版物

  • ステントが迷入してしまった

    藤森尚, 大野彰久, 植田圭二郎, 蓑田洋介, 小川佳宏(担当:共著)

    2022年11月 

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    記述言語:日本語   著書種別:一般書・啓蒙書

  • ESDのための胃癌範囲診断

    江崎充, 蓑田洋介, 伊原栄吉(担当:共著)

    2022年7月 

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    記述言語:日本語   著書種別:学術書

講演・口頭発表等

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MISC

  • 【糖尿病性腎症研究の最前線】糖尿病性腎症の発症機序 肥満・糖尿病における腸内細菌叢の変化

    蓑田 洋介, 松田 やよい, 小川 佳宏

    腎と透析   96 ( 2 )   165 - 169   2024年2月   ISSN:0385-2156

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

    <文献概要>はじめに 人間の腸内環境は,100兆以上の微生物で構成される複雑なエコシステムである。これらの微生物群の大部分は細菌であり,近年の次世代シークエンサーの普及により,これら腸内細菌叢の詳細な分子生物学的解析が可能となった。これによって,腸内細菌叢が人体の代謝,免疫,さらには神経系の機能にまで影響を及ぼすことが明らかになった。特に,腸内細菌叢の乱れが多くの疾患の発症や進行に関与していることが指摘されている。本稿では,腸内細菌叢の分子生物学的側面に焦点を当て,肥満・糖尿病および腎疾患との関連性について述べる。

  • 【神経内分泌腫瘍の新たな知見~膵・消化管神経内分泌腫瘍診療ガイドライン改訂にむけて~】AIを用いた膵神経内分泌腫瘍治癒切除後再発予測モデルの構築と分析

    藤森 尚, 村上 正俊, 蓑田 洋介, 植田 圭二郎, 伊藤 鉄英, 小川 佳宏

    胆と膵   45 ( 1 )   85 - 93   2024年1月   ISSN:0388-9408

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    記述言語:日本語   出版者・発行元:医学図書出版(株)  

    膵神経内分泌腫瘍(pancreatic neuroendocrine tumor:PanNEN)の術後再発率は比較的高く,再発高リスク群を同定することが予後改善に重要である。最近,われわれはPan-NEN切除例に関する多施設後方視的研究を行い,切除例の疫学データを明らかにした。その中で,NET G1/G2 371例を対象としてAIを用いた再発予測モデルを構築した。PanNET G1/G2の術後再発率は14.0%(52/371)であり,random survival forestモデルは従来のCox比例ハザード回帰モデルよりも優れた再発予測性能を示した。5年無再発生存率はKi-67指数と反比例して直線的に低下することから,実臨床ではKi-67指数の実数値が重要である。また,病変サイズが20mmを超えると無再発生存率が急速に低下し,40mmでプラトーに達した。本稿ではPanNEN診療の現状と課題について概説するとともに,われわれの研究結果の一部を紹介する。(著者抄録)

  • 【GERDを極める】病態と診断 非びらん性胃食道逆流症の病態と鑑別診断

    伊原 栄吉, 水流 大尭, 和田 将史, 畑 佳孝, 白 暁鵬, 田中 義将, 蓑田 洋介, 江崎 充, 荻野 治栄

    消化器内視鏡   35 ( 5 )   607 - 614   2023年5月   ISSN:0915-3217

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

  • 大腸腫瘍に対する複数ループ牽引装置を用いた三角牽引補助内視鏡的粘膜下層剥離術(Triangle-traction-assisted endoscopic submucosal dissection with multiple loop traction device for colorectal neoplasms)

    Inada Taisuke, Esaki Mitsuru, Minoda Yosuke

    Digestive Endoscopy   35 ( 4 )   e74 - e75   2023年5月   ISSN:0915-5635

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

  • 治療的EUS Peripancreatic/pancreatic fluid collection(PFC)ドレナージ ステントが迷入してしまった

    藤森 尚, 大野 彰久, 植田 圭二郎, 蓑田 洋介, 小川 佳宏

    消化器内視鏡   2022年12月

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    記述言語:その他  

    DOI: 10.24479/endo.0000000565

  • 【胆膵EUSのトラブルシューティング】治療的EUS Peripancreatic/pancreatic fluid collection(PFC)ドレナージ ステントが迷入してしまった

    藤森 尚, 大野 彰久, 植田 圭二郎, 蓑田 洋介, 小川 佳宏

    消化器内視鏡   34 ( 12 )   1976 - 1980   2022年12月   ISSN:0915-3217

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

  • 【症例から学ぶ胃ESD-改訂ガイドラインwith and beyond-】ESDのための胃癌範囲診断

    江崎 充, 蓑田 洋介, 伊原 栄吉

    消化器内視鏡   34 ( 7 )   1225 - 1228   2022年7月   ISSN:0915-3217

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

  • 膵癌診断における最も優れたモダリティについて(What is the best modality for diagnosing pancreatic cancer?)

    Fujimori Nao, Minoda Yosuke, Ogawa Yoshihiro

    Digestive Endoscopy   34 ( 4 )   744 - 746   2022年5月   ISSN:0915-5635

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

  • ProdiGI牽引ワイヤーを用いた、早期胃癌に対する、病変内牽引補助下内視鏡的粘膜下層剥離術(Intralesional traction-assisted endoscopic submucosal dissection for early gastric neoplasm using the ProdiGI traction wire)

    Shoguchi Yoshihisa, Esaki Mitsuru, Minoda Yosuke

    Digestive Endoscopy   34 ( 3 )   e56 - e57   2022年3月   ISSN:0915-5635

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

  • 膵腫瘤性病変に対する超音波内視鏡下穿刺生検(endoscopic ultrasound guided fine needle biopsy:EUS-FNB)の穿刺回数における検討

    長友周三郎, 蓑田洋介, 藤森尚, 小森圭司, 西岡慧, 高松悠, 寺松克人, 荻野治栄, 大野隆真, 伊原栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   2020年11月

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    記述言語:その他  

  • 【膵炎大全II~膵炎・Up to date~】膵の発生と形成異常 コラム 異所性膵

    蓑田 洋介, 小森 圭司, 荻野 治栄, 伊原 栄吉, 木下 展克, 大野 隆真, 小田 義直, 小川 佳宏

    胆と膵   2019年11月

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    記述言語:日本語  

    異所性膵(heterotopic pancreas)は本来の膵臓とは連続性をもたず、血行支配も異なる他臓器に存在する膵組織のことで、大半の異所性膵は無症状で経過することが多い。消化管管腔内に発生する場合、ときに、サイズが増大し閉塞を起こす症例や出血を伴うもの、癌化を伴うものもあり、胃部不快感や痛み症状が出現することもある。その診断は通常光内視鏡での粘膜下腫瘍の確認ならびに超音波内視鏡検査での内部性状、病理学的評価が有用とされているが、超音波内視鏡下吸引穿刺細胞診(EUS-FNAB)でも診断率は十分とは言えず、診断に苦慮する症例も存在する。癌化が疑われる症例、腫瘍径が30mm以上と大きいもの、急速にサイズが増大するものは悪性の可能性があるとされ外科的加療を考慮する必要があるものの、良性例での増大もあり必ずしも悪性とは言えないことに注意が必要である。(著者抄録)

  • 【膵炎大全II~膵炎・Up to date~】膵の発生と形成異常 コラム 異所性膵 査読

    蓑田 洋介, 小森 圭司, 荻野 治栄, 伊原 栄吉, 木下 展克, 大野 隆真, 小田 義直, 小川 佳宏

    2019年11月

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    記述言語:日本語  

  • Usefulness of the thread-traction method for esophageal endoscopic submucosal dissection in ex vivo pig model with ulcer scar

    Mitsuru Esaki, Aya Iwao, Yosuke Minoda, Seiichiro Sakisaka, Yoshihiro Otsuka, Shinichi Tsuruta, Taizo Hosokawa, Hirotada Akiho, Yudai Tanaka

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2018年11月

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    記述言語:英語  

  • ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION VS. A MUCOSAL INCISION-ASSISTED BIOPSY FOR GASTRIC SUBMUCOSAL TUMORS: A RANDOMIZED COMPARATIVE STUDY

    Yosuke Minoda, Takashi Osoegawa, Soichi Itaba, Aso Akira, Tsutomu Iwasa, Haruei Ogino, Naohiko Harada, Eikichi Ihara, Kazuhiko Nakamura, Yoshihiro Ogawa

    GASTROINTESTINAL ENDOSCOPY   2018年6月

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    記述言語:英語  

▼全件表示

所属学協会

  • 日本消化器内視鏡学会

  • 日本内科学会

  • 日本消化管学会

  • 日本消化器病学会

委員歴

  • 日本消化管学会   代議員   国内

    2024年4月 - 2026年3月   

  • 日本消化器内視鏡学会   評議員   国内

  • 日本消化器病学会   評議員   国内

学術貢献活動

  • 学術論文等の審査

    役割:査読

    2024年

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    種別:査読等 

    外国語雑誌 査読論文数:16

  • Chair man 国際学術貢献

    3rd World Congress of GI Endoscopy, ENDO2022  ( Kyoto Japan ) 2022年5月 - 2024年5月

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    種別:大会・シンポジウム等 

  • 学術論文等の審査

    役割:査読

    2022年

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    種別:査読等 

    外国語雑誌 査読論文数:15

    日本語雑誌 査読論文数:0

    国際会議録 査読論文数:0

    国内会議録 査読論文数:0

  • 学術論文等の審査

    役割:査読

    2021年

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    種別:査読等 

    外国語雑誌 査読論文数:6

  • 学術論文等の審査

    役割:査読

    2020年

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    種別:査読等 

    外国語雑誌 査読論文数:4

共同研究・競争的資金等の研究課題

  • 消化管粘膜バリア機能の日内変動

    2023年4月 - 2026年3月

  • 昼夜環境因子に注目した消化管粘膜バリア機能の概日リズムと分子機構の解明

    研究課題/領域番号:23K15044  2023年 - 2025年

    日本学術振興会  科学研究費助成事業  若手研究

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    担当区分:研究代表者  資金種別:科研費

  • 昼夜環境因子に注目した消化管粘膜バリア機能の概日リズムと分子機構の解明

    研究課題/領域番号:23K15044  2023年 - 2025年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    資金種別:科研費

  • 内視鏡下消化管粘膜バリア機能測定法の確立とLeaky gutを介した全身疾患の制御機構の解明

    2023年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    資金種別:科研費

  • 内視鏡下消化管粘膜バリア機能測定法の確立とLeaky gutを介した全身疾患の制御機構の解明

    2023年

    内視鏡医学振興財団研究助成A

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    担当区分:研究代表者  資金種別:受託研究

  • NAFLDの病態解明

    2021年5月

  • 酸分泌抑制薬に誘導されるLeaky gutを介したNAFLD発症機序の解明

    研究課題/領域番号:21K20904  2021年 - 2022年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    資金種別:科研費

  • 酸分泌抑制薬に誘導されるLeaky gutを介したNAFLD発症機序の解明

    研究課題/領域番号:21K20904  2021年 - 2022年

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    担当区分:研究代表者  資金種別:科研費

▼全件表示

教育活動概要

  • 医学部第 5 学年の臨床実習において、ベッド サイドでの学生指導・教育を行っている。

担当授業科目

  • OSCE

    2023年4月 - 2023年9月   前期

他大学・他機関等の客員・兼任・非常勤講師等

  • 2022年  Clinical Alemana  区分:客員教員  国内外の区分:国外 

国際教育イベント等への参加状況等

  • 2024年4月

    Chile

    VI International Course of Endoscopic Surgery

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    開催国・都市名:チリ

  • 2024年1月

    Interamerican society of digestive disease

    Webinar in Mexico

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    開催国・都市名:メキシコ

  • 2023年7月

    Asian-Pacific Society of Digestive Endoscopy

    APSDE ISDE Outreach Workshop for Advanced Endoscopy – EUS & ERCP –

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    開催国・都市名:インドネシア・ジャカルタ

    参加者数:30

  • 2023年3月

    Clinical Alemana Santiago

    XVJornada De Avances en Gastroenterologia y Hepatologia

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    開催国・都市名:チリ・サンティアゴ

    参加者数:200

社会貢献・国際連携活動概要

  • 社会貢献:論文発表・学会での発表を通じて、消化器病・膵臓病学の最新の 知見を社会へ発信する。
    国際連携活動:最新の超音波内視鏡手技・消化管癌治療手技(EUS・ESD)を光学診療部の海外留学生へ教育する。また アジアを中心にEUS手技が確立していない国へ訪問し、超音波内視鏡の教育・普及を行う。コロナウイルスのパンデミック下では、アジア遠隔医療センター(TEMDEC)と連携し、インターネットを介 したテレカンファレンス(EUS-Asia teleconference)を行っている。また実際に南米、東南アジアにおいて、ESDやEUSの技術指導を現地で行っている。

海外渡航歴

  • 2023年3月

    滞在国名1:チリ共和国   滞在機関名1:Clinical Alemana

学内運営に関わる各種委員・役職等

  • 2024年4月 - 2025年3月   部門 放射線部会委員

  • 2023年4月 - 2024年3月   地区 「内視鏡診断・治療システム」 仕様策定委員

  • 2022年4月 - 2024年3月   地区 トライアルマネージャー

  • 2022年4月 - 2024年3月   地区 高度診療支援システム策定委員, 医療機器安全管理専門委員会

  • 2021年5月   その他 高度診療支援システム策定委員, 医療機器安全管理専門委員会

特筆しておきたい臨床活動

  • 消化管粘膜下腫瘍、膵疾患、消化管機能性異常症は患者数に対して、専門医の数が少なく多くの患者を診療している。稀少疾患である消化管粘膜下腫瘍は本邦有数の患者数を診療しており、診療だけでなく、当院以外の病院でも診断が可能となるように普及していく必要があり、その診断方法や有用性に関して、情報発信を行っている。