Updated on 2025/06/14

写真a

 
TAKAKURA SHU
 
Organization
Kyushu University Hospital Psychosomatic Medicine Lecturer
Kyushu University Hospital Reserch and Clinical Center for Yusho and Dioxin(Concurrent)
School of Medicine Department of Medicine(Concurrent)
Title
Lecturer
Tel
0926425318
Profile
Psychosomatic medicine, Clinical and basic research on eating disorders
Homepage
External link

Research Areas

  • Life Science / Molecular biology

  • Life Science / General internal medicine

Degree

  • Medical science

Research Interests・Research Keywords

  • Research theme: Development of standard treatment for eating disorders

    Keyword: eating disorders

    Research period: 2015.4 - 2025.3

  • Research theme: Long-term starvation stress changes expression pattern of miRNA in mice brain

    Keyword: eating disorders, anorexia nervosa, miRNA

    Research period: 2009.4 - 2023.3

  • Research theme: Two-month Hospitalization Program for Patients with Anorexia Nervosa- A Prospective Study-

    Keyword: Two-month hospitalization, anorexia nervosa, prospective study

    Research period: 2008.4 - 2025.3

Awards

  • Outstanding Non-Trainee Poster

    2022.9   26th World Congress of International College of Psychosomatic Medicine   The effects of the COVID-19 pandemic on patients with eating disorders

  • ベストポスター賞

    2012.8   アジア心身医学会   Chronic starvation stress alters miRNA expressions

  • 基礎医学賞

    2007.2   アジア・オセアニア甲状腺学会   Therapeutic implications of miR-17-92 cluster in anaplastic thyroid cancer cells

  • 若手奨励賞

    2006.11   日本甲状腺学会   甲状腺癌細胞におけるマイクロRNAクラスタ-発現の意義

Papers

  • Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study Invited Reviewed International journal

    Sudo Y, Ota J, Takamura T, Kamashita R, Hamatani S, Numata N, Chhatkuli RB, Yoshida T, Takahashi J, Kitagawa H, Matsumoto K, Masuda Y, Nakazato M, Sato Y, Hamamoto Y, Shoji T, Muratsubaki T, Sugiura M, Fukudo S, Kawabata M, Sunada M, Noda T, Tose K, Isobe M, Kodama N, Kakeda S, Takahashi M, Takaura S, Gondo M, Yoshihara K, Moriguchi Y, Shimizu E, Sekiguchi A, Hirano Y

    Psychological medicine   54 ( 10 )   2347 - 2360   2024.7   ISSN:0033-2917 eISSN:1469-8978

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Psychological Medicine  

    Background Previous research on the changes in resting-state functional connectivity (rsFC) in anorexia nervosa (AN) has been limited by an insufficient sample size, which reduced the reliability of the results and made it difficult to set the whole brain as regions of interest (ROIs). Methods We analyzed functional magnetic resonance imaging data from 114 female AN patients and 135 healthy controls (HC) and obtained self-reported psychological scales, including eating disorder examination questionnaire 6.0. One hundred sixty-four cortical, subcortical, cerebellar, and network parcellation regions were considered as ROIs. We calculated the ROI-to-ROI rsFCs and performed group comparisons. Results Compared to HC, AN patients showed 12 stronger rsFCs mainly in regions containing dorsolateral prefrontal cortex (DLPFC), and 33 weaker rsFCs primarily in regions containing cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between anterior cingulate cortex (ACC) and thalamus (p < 0.01, false discovery rate [FDR] correction). Comparisons between AN subtypes showed that there were stronger rsFCs between right lingual gyrus and right supracalcarine cortex and between left temporal occipital fusiform cortex and medial part of visual network in the restricting type compared to the binge/purging type (p < 0.01, FDR correction). Conclusion Stronger rsFCs in regions containing mainly DLPFC, and weaker rsFCs in regions containing primarily cerebellum, within temporal lobe, between posterior fusiform cortex and lateral part of visual network, and between ACC and thalamus, may represent categorical diagnostic markers discriminating AN patients from HC.

    DOI: 10.1017/S0033291724000485

    Web of Science

    Scopus

    PubMed

  • Systematic Reduction of Gray Matter Volume in Anorexia Nervosa, but Relative Enlargement With Clinical Symptoms in the Prefrontal and Posterior Insular Cortices: A Multicenter Neuroimaging Study Invited Reviewed International journal

    Tose K, Takamura T, Isobe M, Hirano Y, SATO Y, Kodama N, Yoshihara, K Maikusa N, MoriguchiY, Noda T, Mishima R, Kawabata M, Takakura S, Gondo M, Kakeda S, Takahashi M, Ide S, Adachi H, Hamatani S, Kamashita R, Sudo Y, Matsumoto K, Nakazato M, Numata N, Hamamoto Y, Shoji T, Muratsubaki T, Sugiura M, Murai T, Fukudo S, Sekiguchi A

    Molecular psychiatry   29 ( 4 )   891 - 901   2024.1   ISSN:1359-4184 eISSN:1476-5578

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Molecular Psychiatry  

    Although brain morphological abnormalities have been reported in anorexia nervosa (AN), the reliability and reproducibility of previous studies were limited due to insufficient sample sizes, which prevented exploratory analysis of the whole brain as opposed to regions of interest (ROIs). Objective was to identify brain morphological abnormalities in AN and the association with severity of AN by brain structural magnetic resonance imaging (MRI) in a multicenter study, and to conduct exploratory analysis of the whole brain. Here, we conducted a cross-sectional multicenter study using T1-weighted imaging (T1WI) data collected between May 2014 and February 2019 in Japan. We analyzed MRI data from 103 female AN patients (58 anorexia nervosa restricting type [ANR] and 45 anorexia nervosa binge-purging type [ANBP]) and 102 age-matched female healthy controls (HC). MRI data from five centers were preprocessed using the latest harmonization method to correct for intercenter differences. Gray matter volume (GMV) was calculated from T1WI data of all participants. Of the 205 participants, we obtained severity of eating disorder symptom scores from 179 participants, including 87 in the AN group (51 ANR, 36 ANBP) and 92 HC using the Eating Disorder Examination Questionnaire (EDE-Q) 6.0. GMV reduction were observed in the AN brain, including the bilateral cerebellum, middle and posterior cingulate gyrus, supplementary motor cortex, precentral gyrus medial segment, and thalamus. In addition, the orbitofrontal cortex (OFC), ventromedial prefrontal cortex (vmPFC), rostral anterior cingulate cortex (ACC), and posterior insula volumes showed positive correlations with severity of symptoms. This multicenter study was conducted with a large sample size to identify brain morphological abnormalities in AN. The findings provide a better understanding of the pathogenesis of AN and have potential for the development of brain imaging biomarkers of AN. Trial Registration: UMIN000017456. https://center6.umin.ac.jp/cgi-open-bin/icdr/ctr_view.cgi?recptno=R000019303.

    DOI: 10.1038/s41380-023-02378-4

    Web of Science

    Scopus

    PubMed

  • Persistence of gut dysbiosis in individuals with anorexia nervosa despite weight gain Invited Reviewed International journal

    Morisaki Y, Miyata N, Nakashima M, Hata T, Takakura S, Yoshihara K, Suematsu T, Nomoto K, Miyazaki K, Tsuji H, Sudo, N

    PROS One   18 ( 12 )   2023.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Effects of integrated hospital treatment on the default mode, salience, and frontal-parietal networks in anorexia nervosa: A longitudinal resting-state functional magnetic resonance imaging study Reviewed International journal

    Gondo M, Kawai K, Moriguchi Y, Hiwatashi A, Takakura S, Yoshihara K, Morita C, Yamashita M, Eto S, Sudo N

    PROS One   18 ( 5 )   e0283318   2023.5   ISSN:1932-6203

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Plos One  

    The psychopathology of patients with anorexia nervosa has been hypothesized to involve inappropriate self-referential processing, disturbed interoceptive awareness, and excessive cognitive control, including distorted self-concern, disregard of their own starvation state, and extreme weight-control behavior. We hypothesized that the resting-state brain networks, including the default mode, salience and frontal-parietal networks, might be altered in such patients, and that treatment might normalize neural functional connectivity, with improvement of inappropriate self-cognition. We measured resting-state functional magnetic resonance images from 18 patients with anorexia nervosa and 18 healthy subjects before and after integrated hospital treatment (nourishment and psychological therapy). The default mode, salience, and frontal-parietal networks were examined using independent component analysis. Body mass index and psychometric measurements significantly improved after treatment. Before treatment, default mode network functional connectivity in the retrosplenial cortex and salience network functional connectivity in the ventral anterior insula and rostral anterior cingulate cortex were decreased in anorexia nervosa patients compared with those in controls. Interpersonal distrust was negatively correlated with salience network functional connectivity in the rostral anterior cingulate cortex. Default mode network functional connectivity in the posterior insula and frontal-parietal network functional connectivity in the angular gyrus were increased in anorexia nervosa patients compared with those in controls. Comparison between pre- and post-treatment images from patients with anorexia nervosa exhibited significant increases in default mode network functional connectivity in the hippocampus and retrosplenial cortex, and salience network functional connectivity in the dorsal anterior insula following treatment. Frontal-parietal network functional connectivity in the angular cortex showed no significant changes. The findings revealed that treatment altered the functional connectivity in several parts of default mode and salience networks in patients with anorexia nervosa. These alterations of neural function might be associated with improvement of self-referential processing and coping with sensations of discomfort following treatment for anorexia nervosa.

    DOI: 10.1371/journal.pone.0283318

    Web of Science

    Scopus

    PubMed

  • Cardiopulmonary exercise testing for patients with anorexia nervosa: a case-control study Reviewed International journal

    Yamashita M, Kawai K, Toda K, Aso C, Suematsu T, Yokoyama H, Hata T, Takakura S, Sudo N

    Eat Weight Disord   27 ( 8 )   3553 - 3560   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books

  • 思春期の摂食障害のための認知行動療法CBT-Eマニュアル

    リッカルド・ダッレ・グラーヴェ 著, シモーナ・カルージ 著, 吉内 一浩 監訳(Role:Joint translator)

    金子書房  2023.7 

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    Language:Japanese   Book type:Scholarly book

  • CBT-OB 肥満に対する認知行動療法マニュアル 一人ひとりに合わせた治療のために 6章・12章

    リッカルド・ダッレ・グラーヴェ, マッシミリアーノ, サルティラーナ, マルワン・エル・ゴッチ,シモーナ・カルージ 吉内一浩・山内敏正監訳(Role:Joint translator)

    金子書房  2019.7 

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    Language:Japanese   Book type:Scholarly book

  • 心因性の摂食障害

    髙倉 修(Role:Joint author)

    羊土社  2019.1 

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    Responsible for pages:p136-139   Language:Japanese   Book type:Scholarly book

  • 摂食障害治療ハンドブック

    D.M.ガーナー, P.E.ガーフィンケル編, 小牧元監訳(Role:Joint translator)

    金剛出版  2004.2 

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    Responsible for pages:第11章 摂食障害:自己心理学的見地 p203-224   Language:Japanese   Book type:Scholarly book

Presentations

  • 摂食障害と抑うつ・不安 Invited

    髙倉 修

    2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 痩せに対する認知行動療法 Invited

    髙倉 修

    第63回日本心身医学会九州地方会  2024.1 

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    Event date: 2024.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 摂食障害の分子病態 〜神経性やせ症を中心に〜 Invited

    髙倉 修

    第27回日本日本心療内科学会総会  2023.12 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • コロナ禍における摂食障害患者の動向から探るポストコロナを見据えた摂食障害医療の在り方 Invited

    髙倉 修

    第26回日本摂食障害学会学術集会  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • CBT-E 研修会 「神経性やせ症の認知行動療法改良版(CBT-E)研修会」 Invited

    髙倉 修

    第26回日本摂食障害学会学術集会  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

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MISC

  • 過食症と摂食症に対する認知行動療法(CBT-E) Invited

    髙倉 修

    Precision Medicine   8 ( 4 )   20 - 23   2025.4

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 摂食症(摂食障害)診療における臨床倫理 Invited

    髙倉 修

    心身医学   64 ( 3 )   247 - 252   2024.5

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 九州大学心療内科における摂食障害診療の現状と課題

    髙倉 修

    日本心療内科学会誌   2023.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • [摂食障害の治療]認知行動療法 なぜ現在の形式となったのか

    髙倉 修

    精神医学   2023.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 特集 摂食障害:臨床像, 診断と治療 過食性障害 (むちゃ食い症)

    髙倉 修

    精神科Resident   2023.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • Academy for Eating Disorders

  • The Japan Endocrine Society

  • Japan Thyroid Association

  • Japan Society of Eating Disorders

  • Japanese Society of Psycosomatic Medicine

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Committee Memberships

  • 日本摂食障害学会   Steering committee member   Domestic

    2017.11 - Present   

  • 日本摂食障害学会   Executive   Domestic

    2017.11 - Present   

  • 日本摂食障害学会   教育研修担当   Domestic

    2017.11 - Present   

  • 日本心療内科学会   Councilor   Domestic

    2016.11 - Present   

  • 日本心身医学会   Steering committee member   Domestic

    2014.4 - Present   

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Academic Activities

  • BioPsychoSocial Medicine International contribution

    Role(s): Peer review

    2022.4 - 2024.4

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of domestic conference Number of peer-reviewed papers:1

  • 座長

    第332回 日本内科学会九州地方会  ( Japan ) 2021.1

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

    Proceedings of domestic conference Number of peer-reviewed papers:1

  • Frontiers Psychiatry International contribution

    Role(s): Peer review

    2020.1 - 2024.4

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    Type:Academic society, research group, etc. 

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Research Projects

  • 重症神経性やせ症に対する入院認知行動療法のエビデンスと治療バイオマーカーの確立

    Grant number:23K02918  2023 - 2025

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 神経性過食症に対する認知行動療法改良版(CBT-E)の多施設共同無作為化比較試験

    Grant number:21H00957  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 摂食障害に対する認知行動療法の神経科学的エビデンスの創出

    2019.9 - 2024.3

    日本 

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    Authorship:Coinvestigator(s) 

  • 中枢性摂食異常症および中枢神経感作病態を呈する疾患群の脳科学的な病態解明と、エビデンスに基づく患者ケア法の開発

    2017.12 - 2022.3

    国立研究開発法人国立精神・神経医療研究センター(日本) 

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    Authorship:Coinvestigator(s) 

  • 心身症・摂食障害の治療プログラムと臨床マーカーの検証

    2017.4 - 2022.3

    国立研究開発法人国立精神・神経医療研究センター(日本) 

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    Authorship:Coinvestigator(s) 

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Class subject

  • 行動医学入門

    2025.4 - 2026.3   Second semester

  • 臨床医学③

    2025.4 - 2026.3  

  • 心身医学・行動医学

    2025.4 - 2026.3  

  • 臨床実習II

    2025.4 - 2026.3  

  • 臨床実習I

    2025.4 - 2026.3  

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2012  九州大学 健康科学センター  Classification:Part-time lecturer  Domestic/International Classification:Japan 

Other educational activity and Special note

  • 2017  Special Affairs  臨床実習学生に対する面接方法や診察方法、症例提示についての教育

     詳細を見る

    臨床実習学生に対する面接方法や診察方法、症例提示についての教育

  • 2016  Special Affairs  臨床実習学生に対する面接方法や診察方法、症例提示についての教育

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    臨床実習学生に対する面接方法や診察方法、症例提示についての教育

  • 2015  Special Affairs  臨床実習学生に対する面接方法や診察方法、症例提示についての教育

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    臨床実習学生に対する面接方法や診察方法、症例提示についての教育

Outline of Social Contribution and International Cooperation activities

  • Fukuoka Prefectural Treatment and Support Center for Eating Disorders

Social Activities

  • 摂食障害 症例編

    Role(s):Lecturer

    福岡県摂食障害支援拠点病院  原土井病院における研修科医  2025.2

  • 摂食障害 症例編

    Role(s):Lecturer

    福岡県摂食障害支援拠点病院  かしい心療クリニックにおける研修科医  2025.2

  • 摂食障害に対する認知行動療法 〜事例を交えて〜

    Role(s):Lecturer

    福岡県摂食障害支援拠点病院  学校関係者のための研修会  2024.12

  • 摂食症を疑うときには -低体重や食の問題を抱える方への対応-

    Role(s):Lecturer

    高知県医師会  高知県医師会かかりつけ医精神疾患向上研修会  2024.11

  • やせ診断の際の留意点

    Role(s):Lecturer

    福岡市医師会  小児生活習慣病検診実施登録医療研修会  2024.10

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Media Coverage

  • 摂食障害「行動制限 自身と向き合う」 Newspaper, magazine

    読売新聞  2023.2

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    摂食障害「行動制限 自身と向き合う」

  • 医療いのち「摂食障害 進む低年齢化」 Newspaper, magazine

    西日本新聞  2022.4

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    医療いのち「摂食障害 進む低年齢化」

  • 「福岡つながるNews」「コロナ禍で悪化!若い女性に多い摂食障害」 TV or radio program

    J:COM  2021.8

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    「福岡つながるNews」「コロナ禍で悪化!若い女性に多い摂食障害」

  • 「タダイマ!」【レイワの放課後】「摂食障害」を乗り越えて〜福岡の20代女性

    RKB毎日放送  2021.7

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    「タダイマ!」【レイワの放課後】「摂食障害」を乗り越えて〜福岡の20代女性

  • 「摂食障害 コロナ禍で症状悪化の報告」

    NHK 「NEWS WEB」  2021.6

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    「摂食障害 コロナ禍で症状悪化の報告」

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Travel Abroad

  • 2014.8

    Staying countory name 1:United Kingdom   Staying institution name 1:オックスフォード大学 精神科

  • 2011.11

    Staying countory name 1:United Kingdom   Staying institution name 1:オックスフォード大学精神科

    Staying countory name 2:Norway   Staying institution name 2:ベルゲン大学精神科

    Staying countory name 3:Italy   Staying institution name 3:ヴィラガルダ病院

  • 2004.5

    Staying countory name 1:Other   Staying institution name 1:セミパラチンスク医科大学

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / General Internal Medicine (including psychosomatic medicine)

Clinician qualification

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

  • Preceptor

    The Japanese Society of Internal Medicine(JSIM)

  • Specialist

    日本心療内科学会

  • Preceptor

    Japanese Society of Psychosomatic Medicine(JSPM)

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Year of medical license acquisition

  • 1999