Updated on 2024/11/28

Information

 

写真a

 
MASAKI KATSUHISA
 
Organization
Kyushu University Hospital Neurology Lecturer
School of Medicine Department of Medicine（Concurrent）
Title
Lecturer
Contact information
メールアドレス
Tel
0926425340
Profile
[臨床活動]神経免疫疾患専門再来および神経内科初診外来を担当している。多発性硬化症・視神経脊髄炎をはじめとする脱髄性疾患や、重症筋無力症、HTLV-1関連脊髄症、脊髄炎、膠原病関連などの神経免疫疾患、神経変性疾患、てんかん、脳血管障害、頭痛、認知症など神経内科疾患を広く診療している。 [研究活動]脱髄性疾患の神経免疫学的研究、神経病理学的研究を行っており、新規疾患動物モデルの作成や新規治療法開発にも携わっている。 [教育活動]臨床実習や研究室配属における学生教育や指導を担当している。
External link

Degree

  • MD, PhD

Research History

  • なし

Research Interests・Research Keywords

  • Research theme：Expression of mutant α-synucelin in oligodendrocytes induces remarkable glial inflammation and demyelination

    Keyword：αsynuclein oligodendrocyte neurodegeneration microglia astrocyte

    Research period： 2018.12 - 2025.12

  • Research theme：A novel model for treatment of hypertrophic pachymeninigitis

    Keyword：hypertrophic pachymeningitis, LATY136F mutant mice

    Research period： 2017.6 - 2021.6

  • Research theme：TDP-43 proteinopathy in TMEV infection

    Keyword：TMEV, TDP-43, multiple sclerosis, demyelination, amyotrophic lateral sclerosis

    Research period： 2016.12 - 2018.11

  • Research theme：Glial assenbly and their early disruption in demyelinating disorders

    Keyword：connexin, astrocyte, oligodendrocyte, multiple sclerosis, glia assenbly

    Research period： 2015.6 - 2021.6

  • Research theme：Neuroimmunology and neuropathological study of human demyelinating disorders

    Keyword：multiple sclerosis, neuromyelitis optica, Balo's disease

    Research period： 2008.4 - 2021.3

Awards

  • Travel Award

    2019.7   The 144th Annual Meeting of the American Neurological Association  

  • 第3回MSサマーカレッジ学長賞

    2016.8  

  • Travel Award for ECTRIMS

    2015.9  

  • 第1回日本神経免疫学会研究創世賞　最優秀賞

    2014.9   日本神経免疫学会  

  • Young Neuroimmunologist Award

    2013.11  

  • Travel Award

    2012.7   The 28th ECTRIMS Congress  

  • Travel Award

    2011.7   The 27th ECTRIMS Congress  

  • 学会賞

    2010.8  

  • Travel Award

    2009.7   The 25th ECTRIMS Congress  

▼display all

Papers

  • Focal 18F-fluorodeoxyglucose uptake in spinal dural arteriovenous fistula: A report of two cases Reviewed International journal

    Hayashida H, Masaki K, Ogata H, Yamaguchi T, Tanaka K, Arimura K, Maruoka Y, Kikuchi K, Togao O, Yamasaki R, Isobe N

    Neurology and Clinical Neuroscience   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy. Reviewed International journal

    Nishimura Y, Masaki K, Matsuse D, Yamaguchi H, Tanaka T, Matsuo E, Hayashida S, Watanabe M, Matsushita T, Sadashima S, Sasagasako N, Yamasaki R, Isobe N, Iwaki T, Kira JI.

    Brain Pathol   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/bpa.13131.

  • Reversible Parkinsonism Caused by Lumboperitoneal Shunt Overdrainage. Reviewed International journal

    Takeuchi H, Masaki K, Ogata H, Nagata S, Shimogawa T, Yamasaki R, Isobe N.

    Neurology   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Genetic factors for susceptibility to and manifestations of neuromyelitis optica Reviewed International journal

    Matsushita T, Masaki K, Isobe N, Sato S, Yamamoto K, Nakamura Y, Watanabe M, Suenaga T, Kira JI; Japan Multiple Sclerosis Genetic Consortium.

    Ann Clin Transl Neurol   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders Reviewed International journal

    2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Connexins in neuromyelitis optica: a link between astrocytopathy and demyelination Reviewed International journal

    Richard C, Ruiz A, Cavagna S, Bigotte M, Vukusic S, Masaki K, Suenaga T, Kira JI, Giraudon P, Marignier R.

    Brain   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • RNA-binding Protein Altered Expression and Mislocalization in MS Reviewed International journal

    Neurol Neuroimmunol Neuroinflamm   2020.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis. Reviewed International journal

    Zhao Y, Yamasaki R, Yamaguchi H, Nagata S, Une H, Cui Y, Masaki K, Nakamuta Y, Iinuma K, Watanabe M, Matsushita T, Isobe N, Kira JI.

    Proc Natl Acad Sci U S A   2020.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection. Reviewed International journal

    Masaki K, Sonobe Y, Ghadge G, Pytel P, Roos RP.

    PLoS Pathogens   2019.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • A novel model for treatment of hypertrophic pachymeningitis. Reviewed International journal

    Cui Y, Masaki K, Zhang X, Yamasaki R, Fujii T, Ogata H, Hayashida S, Yamaguchi H, Hyodo F, Eto H, Koyama S, Iinuma K, Yonekawa T, Matsushita T, Yoshida M, Yamada K, Kawano M, Malissen M, Malissen B, Kira J.

    Ann Clin Transl Neurol   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis. Reviewed International journal

    Kobayakawa Y, Masaki K, Yamasaki R, Shiraishi W, Hayashida S, Hayashi S, Okamoto K, Matsushita T, Kira JI.

    Front Neurosci.   2018.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress. Reviewed International journal

    Sonobe Y, Ghadge G, Masaki K, Sendoel A, Fuchs E, Roos RP.

    Neurobiol Dis.   2018.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Early and extensive spinal white matter involvement in neuromyelitis optica. Reviewed International journal

    Hayashida S, Masaki K, Yonekawa T, Suzuki SO, Hiwatashi A, Matsushita T, Watanabe M, Yamasaki R, Suenaga T, Iwaki T, Murai H, Kira JI.

    Brain Pathol.   2017.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation. Reviewed International journal

    Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Matsushita T, Suzumura A, Kira JI.

    Sci Rep.   2016.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation. Reviewed International journal

    Yamasaki R, Fujii T, Wang B, Masaki K, Kido MA, Yoshida M, Matsushita T, Kira JI.

    J Neurosci.   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model. Reviewed International journal

    Cui Y, Masaki K, Yamasaki R, Imamura S, Suzuki SO, Hayashi S, Sato S, Nagara Y, Kawamura MF, Kira J.

    J Neuroinflammation   6 ( 11 )   42   2014.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1742-2094-11-42.

  • Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica. Reviewed International journal

    Masaki K, Suzuki SO, Matsushita T, Matsuoka T, Imamura S, Yamasaki R, Suzuki M, Suenaga T, Iwaki T, Kira J.

    PLOS ONE   2013.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction. Reviewed International journal

    123   887 - 900   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • MRIにて後下小脳動脈瘤と広範な延髄・高位頸髄の信号異常をみとめ、反復性呼吸不全で死亡、静脈性循環障害がうたがわれた86歳女性例

    真崎勝久, 大野雅治, 前田浩喜, 濱田哲夫, 岩城徹, 友田宏幸

    臨床神経学   2008.8

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • 短期間で寛解再発をきたした橋本脳症の1例 Reviewed

    真崎勝久, 金森祐治, 栄信孝, 迎伸孝, 山田猛

    神経内科   2008.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • IgG抗GT1a抗体単独陽性で味覚障害を伴ったacute oropharyngeal palsyの1例 Reviewed

    真崎勝久, 大八木保政, 村井弘之, 菊池仁志, 舩越慶, 薄敬一郎, 谷脇考恭, 吉良潤一

    末梢神経   2005.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • The Efficacy of Eculizumab in the Acute Phase of Neuromyelitis Optica Spectrum Disorder: A Case Series Study.

    Watanabe M, Masaki K, Tanaka E, Matsushita T, Isobe N

    Cureus   16 ( 11 )   e73205   2024.11   （ ISSN:2168-8184 ）

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    Language：English  

    DOI： 10.7759/cureus.73205

    PubMed

  • A rapidly progressive multiple system atrophy-cerebellar variant model presenting marked glial reactions with inflammation and spreading of α-synuclein oligomers and phosphorylated α-synuclein aggregates

    Yamaguchi, H; Nishimura, Y; Matsuse, D; Sekiya, H; Masaki, K; Tanaka, T; Saiga, T; Harada, M; Kira, YI; Dickson, DW; Fujishima, K; Matsuo, E; Tanaka, KF; Yamasaki, R; Isobe, N; Kira, JI

    BRAIN BEHAVIOR AND IMMUNITY   121   122 - 141   2024.10   （ ISSN:0889-1591 eISSN:1090-2139 ）

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    Language：English   Publisher：Brain, Behavior, and Immunity  

    Multiple system atrophy (MSA) is a severe α-synucleinopathy facilitated by glial reactions; the cerebellar variant (MSA-C) preferentially involves olivopontocerebellar fibres with conspicuous demyelination. A lack of aggressive models that preferentially involve olivopontocerebellar tracts in adulthood has hindered our understanding of the mechanisms of demyelination and neuroaxonal loss, and thus the development of effective treatments for MSA. We therefore aimed to develop a rapidly progressive mouse model that recaptures MSA-C pathology. We crossed Plp1-tTA and tetO-SNCA*A53T mice to generate Plp1-tTA::tetO-SNCA*A53T bi-transgenic mice, in which human A53T α-synuclein—a mutant protein with enhanced aggregability—was specifically produced in the oligodendrocytes of adult mice using Tet-Off regulation. These bi-transgenic mice expressed mutant α-synuclein from 8 weeks of age, when doxycycline was removed from the diet. All bi-transgenic mice presented rapidly progressive motor deterioration, with wide-based ataxic gait around 22 weeks of age and death around 30 weeks of age. They also had prominent demyelination in the brainstem/cerebellum. Double immunostaining demonstrated that myelin basic protein was markedly decreased in areas in which SM132, an axonal marker, was relatively preserved. Demyelinating lesions exhibited marked ionised calcium-binding adaptor molecule 1-, arginase-1-, and toll-like receptor 2-positive microglial reactivity and glial fibrillary acidic protein-positive astrocytic reactivity. Microarray analysis revealed a strong inflammatory response and cytokine/chemokine production in bi-transgenic mice. Neuronal nuclei-positive neuronal loss and patchy microtubule-associated protein 2-positive dendritic loss became prominent at 30 weeks of age. However, a perceived decrease in tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta in bi-transgenic mice compared with wild-type mice was not significant, even at 30 weeks of age. Wild-type, Plp1-tTA, and tetO-SNCA*A53T mice developed neither motor deficits nor demyelination. In bi-transgenic mice, double immunostaining revealed human α-synuclein accumulation in neurite outgrowth inhibitor A (Nogo-A)-positive oligodendrocytes beginning at 9 weeks of age; its expression was further increased at 10 to 12 weeks, and these increased levels were maintained at 12, 24, and 30 weeks. In an α-synuclein-proximity ligation assay, α-synuclein oligomers first appeared in brainstem oligodendrocytes as early as 9 weeks of age; they then spread to astrocytes, neuropil, and neurons at 12 and 16 weeks of age. α-Synuclein oligomers in the brainstem neuropil were most abundant at 16 weeks of age and decreased thereafter; however, those in Purkinje cells successively increased until 30 weeks of age. Double immunostaining revealed the presence of phosphorylated α-synuclein in Nogo-A-positive oligodendrocytes in the brainstem/cerebellum as early as 9 weeks of age. In quantitative assessments, phosphorylated α-synuclein gradually and successively accumulated at 12, 24, and 30 weeks in bi-transgenic mice. By contrast, no phosphorylated α-synuclein was detected in wild-type, tetO-SNCA*A53T, or Plp1-tTA mice at any age examined. Pronounced demyelination and tubulin polymerisation, promoting protein-positive oligodendrocytic loss, was closely associated with phosphorylated α-synuclein aggregates at 24 and 30 weeks of age. Early inhibition of mutant α-synuclein expression by doxycycline diet at 23 weeks led to fully recovered demyelination; inhibition at 27 weeks led to persistent demyelination with glial reactions, despite resolving phosphorylated α-synuclein aggregates. In conclusion, our bi-transgenic mice exhibited progressively increasing demyelination and neuroaxonal loss in the brainstem/cerebellum, with rapidly progressive motor deterioration in adulthood. These mice showed marked microglial and astrocytic reactions with inflammation that was closely associated with phosphorylated α-synuclein aggregates. These features closely mimic human MSA-C pathology. Notably, our model is the first to suggest that α-synuclein oligomers may spread from oligodendrocytes to neurons in transgenic mice with human α-synuclein expression in oligodendrocytes. This model of MSA is therefore particularly useful for elucidating the in vivo mechanisms of α-synuclein spreading from glia to neurons, and for developing therapies that target glial reactions and/or α-synuclein oligomer spreading and aggregate formation in MSA.

    DOI： 10.1016/j.bbi.2024.07.004

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  • Three-dimensional magnetic resonance imaging of Baló-like concentric lesion in multiple sclerosis

    Iwao, K; Masaki, K; Tanaka, E; Watanabe, M; Kira, Y; Shinoda, K; Matsushita, T; Araki, S; Togao, O; Isobe, N

    NEUROLOGY AND CLINICAL NEUROSCIENCE   2024.8   （ ISSN:2049-4173 ）

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    Publisher：Neurology and Clinical Neuroscience  

    DOI： 10.1111/ncn3.12852

    Web of Science

    Scopus

  • Oral management for a patient with trismus accompanied by Isaacs' syndrome: a case report

    Tani, A; Mizutani, S; Watanabe, M; Irie, T; Masaki, K; Isobe, N; Kashiwazaki, H

    BMC ORAL HEALTH   24 ( 1 )   716   2024.6   （ ISSN:1472-6831 ）

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    Language：English   Publisher：BMC Oral Health  

    Background: Isaacs’ syndrome, also known as neuromyotonia or peripheral nerve hyperexcitability, is a rare disorder that affects the peripheral nervous system. Clinical findings include cramps, fasciculations, and myokymia; however, there are few reports of dental treatment for trismus. Case presentation: A patient with trismus due to Isaacs’ syndrome experienced swelling and pain in the gingiva surrounding his right lower first molar. He was diagnosed with chronic apical periodontitis by a dentist near his home. However, the patient was informed that dental treatment and medication could not be administered because of the presence of Isaacs’ syndrome, and he visited the Geriatric Dentistry and Perioperative Oral Care Center at Kyushu University Hospital 2 weeks later. The patient’s painless mouth-opening distance (between incisors) was 20 mm at that time, and medication, including amoxicillin capsules and acetaminophen, was administered because the dental extraction forceps or endodontic instruments were difficult to insert into the oral cavity for treatment. Two months after his initial visit, the patient visited us complaining of pain in the same area. However, he had recently undergone plasmapheresis treatment in neurology to alleviate limited mouth opening and systemic myalgia, resulting in a pain-free mouth-opening distance of approximately 35 mm. During this temporary period in which he had no restriction in mouth opening, we performed tooth extraction and bridge restoration on the mandibular right first molar and created an oral appliance for sleep bruxism. Conclusions: Plasmapheresis therapy transiently reduced trismus, rendering dental interventions feasible, albeit temporarily. This case report underscores the importance of close collaboration between neurologists and dentists who encounter similar cases while furnishing valuable insights to inform dental treatment planning.

    DOI： 10.1186/s12903-024-04485-2

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  • Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model

    Takase, EO; Yamasaki, R; Nagata, S; Watanabe, M; Masaki, K; Yamaguchi, H; Kira, J; Takeuchi, H; Isobe, N

    SCIENTIFIC REPORTS   14 ( 1 )   10877   2024.5   （ ISSN:2045-2322 ）

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    Language：English   Publisher：Scientific Reports  

    In chronic stages of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalitis (EAE), connexin (Cx)43 gap junction channel proteins are overexpressed because of astrogliosis. To elucidate the role of increased Cx43, the central nervous system (CNS)-permeable Cx blocker INI-0602 was therapeutically administered. C57BL6 mice with chronic EAE initiated by MOG35-55 received INI-0602 (40 mg/kg) or saline intraperitoneally every other day from days post-immunization (dpi) 17–50. Primary astroglia were employed to observe calcein efflux responses. In INI-0602-treated mice, EAE clinical signs improved significantly in the chronic phase, with reduced demyelination and decreased CD3+ T cells, Iba-1+ and F4/80+ microglia/macrophages, and C3+GFAP+ reactive astroglia infiltration in spinal cord lesions. Flow cytometry analysis of CD4+ T cells from CNS tissues revealed significantly reduced Th17 and Th17/Th1 cells (dpi 24) and Th1 cells (dpi 50). Multiplex array of cerebrospinal fluid showed significantly suppressed IL-6 and significantly increased IL-10 on dpi 24 in INI-0602-treated mice, and significantly suppressed IFN-γ and MCP-1 on dpi 50 in the same group. In vitro INI-0602 treatment inhibited ATP-induced calcium propagations of Cx43+/+ astroglial cells to similar levels of those of Cx43−/− cells. Astroglial Cx43 hemichannels represent a novel therapeutic target for chronic EAE and MS.

    DOI： 10.1038/s41598-024-61508-2

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  • Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation. Reviewed International journal

    Nagata S, Yamasaki R, Takase EO, Iida K, Watanabe M, Masaki K, Wijering MHC, Yamaguchi H, Kira JI, Isobe N.

    Biology   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis. Reviewed International journal

    Leppert D, Watanabe M, Schaedelin S, Piehl F, Furlan R, Gastaldi M, Lambert J, Evertsson B, Fink K, Matsushita T, Masaki K, Isobe N, Kira JI, Benkert P, Maceski A, Willemse E, Oechtering J, Orleth A, Meier S, Kuhle J.

    J Neurol Neurosurg Psychiatry   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Effect of smoking on disease activity in multiple sclerosis patients treated with dimethyl fumarate or fingolimod. Reviewed International journal

    Tanaka E, Watanabe M, Fukumoto S, Masaki K, Yamasaki R, Matsushita T, Isobe N.

    Mult Scler Relat Disord   2023.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation. Reviewed International journal

    Hashimoto Y, Yamasaki R, Ko S, Matsuo E, Kobayakawa Y, Masaki K, Matsuse D, Isobe N.

    Int J Mol Sci   2022.12

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  • Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder A Retrospective, Cross-sectional Analysis

    Müller, J; Sinnecker, T; Wendebourg, MJ; Schläger, R; Kuhle, J; Schädelin, S; Benkert, P; Derfuss, T; Cattin, P; Jud, C; Spiess, F; Amann, M; Lincke, T; Barakovic, M; Cagol, A; Tsagkas, C; Parmar, K; Pröbstel, AK; Reimann, S; Asseyer, S; Duchow, A; Brandt, A; Ruprecht, K; Hadjikhani, N; Fukumoto, S; Watanabe, M; Masaki, K; Matsushita, T; Isobe, N; Kira, JI; Kappos, L; Würfel, J; Granziera, C; Paul, F; Yaldizli, Ö

    NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION   9 ( 3 )   2022.5   （ ISSN:2332-7812 ）

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    Language：English   Publisher：Neurology: Neuroimmunology and NeuroInflammation  

    Background and ObjectivesThe choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger choroid plexus in multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the choroid plexus is similarly involved in MS and in neuromyelitis optica spectrum disorder (NMOSD). Thus, the aim of this study was to compare the choroid plexus volume in MS and NMOSD.MethodsIn this retrospective, cross-sectional study, patients were included by convenience sampling from 4 international MS centers. The choroid plexus of the lateral ventricles was segmented fully automatically on T1-weighted MRI sequences using a deep learning algorithm (Multi-Dimensional Gated Recurrent Units). Uni- and multivariable linear models were applied to investigate associations between the choroid plexus volume, clinically meaningful disease characteristics, and MRI parameters.ResultsWe studied 180 patients with MS and 98 patients with NMOSD. In total, 94 healthy individuals and 47 patients with migraine served as controls. The choroid plexus volume was larger in MS (median 1,690 µL, interquartile range [IQR] 648 µL) than in NMOSD (median 1,403 µL, IQR 510 µL), healthy individuals (median 1,533 µL, IQR 570 µL), and patients with migraine (median 1,404 µL, IQR 524 µL; all p < 0.001), whereas there was no difference between NMOSD, migraine, and healthy controls. This was also true when adjusted for age, sex, and the intracranial volume. In contrast to NMOSD, the choroid plexus volume in MS was associated with the number of T2-weighted lesions in a linear model adjusted for age, sex, total intracranial volume, disease duration, relapses in the year before MRI, disease course, Expanded Disability Status Scale score, disease-modifying treatment, and treatment duration (beta 4.4; 95% CI 0.78-8.1; p = 0.018).DiscussionThis study supports an involvement of the choroid plexus in MS in contrast to NMOSD and provides clues to better understand the respective pathogenesis.

    DOI： 10.1212/NXI.0000000000001147

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  • Shadowboxing-induced reflex seizures in a patient with focal epilepsy. Reviewed International journal

    Okadome T, Takeuchi H, Yamaguchi T, Mukaino T, Ogata H, Masaki K, Shigeto H, Isobe N.

    Epilepsy Behav Rep   2022.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis. Reviewed International journal

    Neurol Neuroimmunol Neuroinflamm   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Eculizumab in refractory generalized myasthenia gravis previously treated with rituximab: subgroup analysis of REGAIN and its extension study. Reviewed International journal

    Siddiqi ZA, Nowak RJ, Mozaffar T, O'Brien F, Yountz M, Patti F; REGAIN Study Group.

    Muscle Nerve   2021.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Serum Anti-oligodendrocyte Autoantibodies in Patients With Multiple Sclerosis Detected by a Tissue-Based Immunofluorescence Assay. Reviewed International journal

    Miyachi Y, Fujii T, Yamasaki R, Tsuchimoto D, Iinuma K, Sakoda A, Fukumoto S, Matsushita T, Masaki K, Isobe N, Nakabeppu Y, Kira JI.

    Front Neurol   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination. Reviewed International journal

    J Neuroinflammation   2021.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data. Reviewed International journal

    Watanabe M, Nakamura Y, Sato S, Niino M, Fukaura H, Tanaka M, Ochi H, Kanda T, Takeshita Y, Yokota T, Nishida Y, Matsui M, Nagayama S, Kusunoki S, Miyamoto K, Mizuno M, Kawachi I, Saji E, Ohashi T, Shimohama S, Hisahara S, Nishiyama K, Iizuka T, Nakatsuji Y, Okuno T, Ochi K, Suzumura A, Yamamoto K, Kawano Y, Tsuji S, Hirata M, Sakate R, Kimura T, Shimizu Y, Nagaishi A, Okada K, Hayashi F, Sakoda A, Masaki K, Shinoda K, Isobe N, Matsushita T, Kira JI.

    Sci Rep   2021.1

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  • A new clustering method identifies multiple sclerosis-specific T-cell receptors. Reviewed International journal

    Hayashi F, Isobe N, Glanville J, Matsushita T, Maimaitijiang G, Fukumoto S, Watanabe M, Masaki K, Kira JI.

    Ann Clin Transl Neurol   2021.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension. Reviewed International journal

    Mantegazza R, Wolfe GI, Muppidi S, Wiendl H, Fujita KP, O'Brien FL, Booth HDE, Howard JF Jr; REGAIN Study Group.

    Neurology   2021.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type Reviewed International journal

    Matsuse D, Yamasaki R, Maimaitijiang G, Yamaguchi H, Masaki K, Isobe N, Matsushita T, Kira JI.

    J Neuroimmunol   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study Reviewed International journal

    Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H, Kushima I, Kawakami I, Itokawa M, Arai M, Hayashida S, Masaki K, Kira JI, Kawashima K, Ozaki N.

    Schizophr Res   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study Invited Reviewed International journal

    Torii Y, Iritani S, Marui T, Sekiguchi H, Habuchi C, Fujishiro H, Kushima I, Oshima K, Niizato K, Hayashida S, Masaki K, Kira JI, Yoshida M, Ozaki N.

    Schizophr Res.   2020.7

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Contribution of Cortical Lesions to Cognitive Impairment in Japanese Patients With Multiple Sclerosis Reviewed International journal

    Shinoda K, Matsushita T, Nakamura Y, Masaki K, Sakai S, Nomiyama H, Togao O, Hiwatashi A, Niino M, Isobe N, Kira JI.

    Sci Rep   2020.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Environmental risk factors for multiple sclerosis in Japanese people. Reviewed International journal

    Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Masaki K, Isobe N, Yamasaki R, Kira JI.

    Mult Scler Relat Disord.   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Long-term use of interferon-β in multiple sclerosis increases Vδ1-Vδ2-Vγ9- γδ T cells that are associated with a better outcome. Reviewed International journal

    2019.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis. Reviewed International journal

    Zhang X, Fujii T, Ogata H, Yamasaki R, Masaki K, Cui Y, Matsushita T, Isobe N, Kira JI.

    J Neuroimmunol.   2019.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia. Reviewed International journal

    Fang M, Yamasaki R, Li G, Masaki K, Yamaguchi H, Fujita A, Isobe N, Kira JI.

    Front Immunol.   2018.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients. Reviewed International journal

    Marui T, Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H, Oshima K, Niizato K, Hayashida S, Masaki K, Kira J, Ozaki N.

    Acta Neuropsychiatr.   2018.8

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  • HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis. Reviewed International journal

    Shinoda K, Matsushita T, Nakamura Y, Masaki K, Yamasaki R, Yamaguchi H, Togao O, Hiwatashi A, Kira JI.

    Mult Scler.   2018.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Association of Decreased Percentage of Vδ2+Vγ9+ γδ T Cells With Disease Severity in Multiple Sclerosis. Reviewed International journal

    2018.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway. Reviewed International journal

    2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Antibodies to myelin oligodendrocyte glycoprotein are uncommon in Japanese opticospinal multiple sclerosis. Reviewed International journal

    Ramanathan S, Sato S, Matsushita T, Masaki K, Yamasaki R, Dale RC, Kira J, Brilot F.

    Mult Scler.   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Copy number variations in multiple sclerosis and neuromyelitis optica. Reviewed International journal

    Sato S, Yamamoto K, Matsushita T, Isobe N, Kawano Y, Iinuma K, Niino M, Fukazawa T, Nakamura Y, Watanabe M, Yonekawa T, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira J; Japan Multiple Sclerosis Genetics Consortium.

    Ann Neurol.   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Peripheral blood T cell dynamics predict relapse in multiple sclerosis patients on fingolimod. Reviewed International journal

    Song ZY, Yamasaki R, Kawano Y, Sato S, Masaki K, Yoshimura S, Matsuse D, Murai H, Matsushita T, Kira J.

    PLoS One   2015.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Decreased serum vitamin D levels in Japanese patients with multiple sclerosis. Reviewed International journal

    Niino M, Sato S, Fukazawa T, Masaki K, Miyazaki Y, Matsuse D, Yamasaki R, Takahashi E, Kikuchi S, Kira J.

    J Neuroimmunol.   2015.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • A nationwide survey of hypertrophic pachymeningitis in Japan. Reviewed International journal

    Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, Yamasaki R, Yoshida M, Kusunoki S, Sakata K, Fujii K, Kira J.

    J Neurol Neurosurg Psychiatry.   2014.7

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients. Reviewed International journal

    Yoshimura S, Isobe N, Matsushita T, Masaki K, Sato S, Kawano Y, Ochi H, Kira J.

    PLoS One   2014.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis). Reviewed International journal

    Suzuki M, Kawasaki H, Masaki K, Suzuki SO, Terada T, Tsuchida T, Tokuyama T, Kono S, Komori T, Baba S, Kira J, Miyajima H.

    Intern Med.   2013.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica. Reviewed International journal

    Isobe N, Yonekawa T, Matsushita T, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J.

    Neurochem Res.   2013.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status. Reviewed International journal

    Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Masaki K, Sato S, Kawano Y, Kira J; South Japan Multiple Sclerosis Genetics Consortium.

    J Neurol Neurosurg Psychiatry.   2013.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica. Reviewed International journal

    Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J.

    Mult Scler.   2012.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese. Reviewed International journal

    Sato S, Isobe N, Yoshimura S, Kanamori Y, Masaki K, Matsushita T, Kira J.

    J Neuroimmunol.   2012.10

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Genetic and infectious profiles of Japanese multiple sclerosis patients. Reviewed International journal

    Yoshimura S, Isobe N, Yonekawa T, Matsushita T, Masaki K, Sato S, Kawano Y, Yamamoto K, Kira J; South Japan Multiple Sclerosis Genetics Consortium.

    PLoS One.   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Comparison of clinical, immunological and neuroimaging features between anti-aquaporin-4 antibody-positive and antibody-negative Sjogren's syndrome patients with central nervous system manifestations. Reviewed International journal

    Estiasari R, Matsushita T, Masaki K, Akiyama T, Yonekawa T, Isobe N, Kira J.

    Mult Scler.   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Clinical disability progression and platelet GP IIb/IIIa values in patients with atopic myelitis. Reviewed International journal

    Ainiding G, Yamashita K, Torii T, Furuta K, Isobe N, Matsushita T, Masaki K, Matsumoto S, Kira J.

    J Neuroimmunol.   2012.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians. Reviewed International journal

    Fang L, Isobe N, Yoshimura S, Yonekawa T, Matsushita T, Masaki K, Doi H, Ochi K, Miyamoto K, Kawano Y, Kira J; South Japan Multiple Sclerosis Genetics Consortium.

    Neurology   2011.6

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status. Reviewed International journal

    Matsushita T, Isobe N, Piao H, Matsuoka T, Ishizu T, Doi H, Masaki K, Yoshiura T, Yamasaki R, Ohyagi Y, Kira J.

    J Neurol Sci.   2010.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica. Reviewed International journal

    Li W, Minohara M, Piao H, Matsushita T, Masaki K, Matsuoka T, Isobe N, Su JJ, Ohyagi Y, Kira J.

    Mult Scler.   2009.12

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    Language：English   Publishing type：Research paper (scientific journal)  

▼display all

Books

  • Balo病　アクチュアル脳・神経疾患の臨床．辻省次（総編集）、吉良潤一（専門編集）.中山書店

    眞﨑勝久、吉良潤一（ Role： Joint author）

    2016.3 

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    Language：Japanese   Book type：Scholarly book

  • Tumefactive MS アクチュアル脳・神経疾患の臨床．辻省次（総編集）、吉良潤一（専門編集）．中山書店

    眞﨑勝久、吉良潤一（ Role： Joint author）

    中山書店  2016.3 

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    Language：Japanese   Book type：Scholarly book

  • 神経病理．アクチュアル脳・神経疾患の臨床．最新アプローチ 多発性硬化症と視神経脊髄炎．辻省次（総編集）．吉良潤一（専門編集）．

    眞﨑勝久、吉良潤一（ Role： Joint author）

    中山書店  2012.10 

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    Responsible for pages：pp. 29-36   Language：Japanese   Book type：Scholarly book

  • 多発性硬化症の類縁疾患　バロー病． アクチュアル脳・神経疾患の臨床．最新アプローチ　多発性硬化症と視神経脊髄炎．辻省次（総編集）．吉良潤一（専門編集）．

    眞﨑勝久、吉良潤一（ Role： Joint author）

    中山書店  2012.10 

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    Responsible for pages：pp. 99-103   Language：Japanese   Book type：Scholarly book

  • 薬剤ごとの違いがわかる ステロイドの使い分け　脳神経疾患

    眞﨑勝久、吉良潤一（ Role： Joint author）

    羊土社  2010.2 

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    Language：Japanese   Book type：Scholarly book

Presentations

  • 変性の立場からMSの病態に迫る Invited

    眞﨑勝久

    第35回日本神経免疫学会学術集会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • Approach to tumefactive brain lesions Invited International conference

    Katsuhisa Masaki

    the Pan Asian Course for Training in MS And Neuroimmunology (PACTMAN)  2023.5 

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    Event date： 2023.5

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • タイラーウイルス感染によるTDP-43 proteinopathyと神経障害・脱髄への関与 Invited

    眞﨑勝久

    第32回日本神経免疫学会学術集会  2020.10 

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    Event date： 2020.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Glial pathology of multiple sclerosis, neuromyelitis optica spectrum disorders; insight from human pathology and genetics Invited International conference

    Katsuhisa Masaki

    The 12th PACTRIMS  2019.11 

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    Event date： 2019.11

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Singapore  

  • Update and Review of Baló’s Concentric Sclerosis Invited International conference

    2017.9 

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    Event date： 2019.8

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Connexin gap junction pathology in active MS, Baló’s disease and NMO

    The 55th Annual Meeting of the Japanese Society of Neurology　日本神経学会学術大会  2014.5 

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    Event date： 2019.8

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Connexin gap junction pathology in MS, Baló’s disease and NMO

    The 55th Annual Meeting of the Japanese Society of Neuropathology 日本神経病理学会  2014.6 

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    Event date： 2019.8

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • MSにおけるastrocytopathy

    眞﨑勝久

    第26回日本神経免疫学会学術集会  2014.9 

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    Event date： 2019.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Extensive Loss of Astrocytic Monocarboxylate Transporter 4 in Active Lesions of Multiple Sclerosis and Neuromyelitis Optica International conference

    Katsuhisa Masaki

    The 31st ECTRIMS  2015.10 

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    Event date： 2019.8

    Language：English  

    Country：Japan  

  • Common and Distinct Features of Immunopathology Between MS and NMO Invited International conference

    Katsuhisa Masaki

    The 8th PACTRIMS  2015.11 

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    Event date： 2019.8

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Glial pathology of multiple sclerosis, neuromyelitis optica spectrum disorders and Baló’s disease

    第60回日本神経学会学術大会  2019.5 

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    Event date： 2019.5

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 世界初の肥厚性硬膜炎モデルを用いた創薬

    眞﨑勝久

    第59回日本神経学会学術大会  2018.5 

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    Event date： 2018.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Rapidly progressive multiple sclerosis and gliopathy Invited International conference

    Katsuhisa Masaki

    The 6th PACTRIMS  2013.11 

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    Event date： 2013.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Connexin gap junction pathology in active MS, Baló’s disease and NMO Invited

    第12回MSワークショップ  2013.8 

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    Event date： 2013.8

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Molecular pathology of astrocytopathy in Baló’s disease and tumefactive MS. Invited International conference

    2012.9 

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    Event date： 2012.9

    Language：English   Presentation type：Oral presentation (general)  

    Venue：北京   Country：China  

  • Connexins in Demyelinating Disorders Invited

    Masaki K and Kira J

    The 35th Annual Meeting of the Japan Neuroscience Society  2012.9 

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    Event date： 2012.9

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • アストロサイトパチーと脳細胞間情報伝達機構の修復戦略 Invited

    眞﨑勝久

    第53回日本神経学会学術大会  2012.5 

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    Event date： 2012.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • Early disruption of astrocytic connexins in multiple sclerosis, Baló’s disease and neuromyelitis optica. International conference

    2012.10 

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    Language：English  

    Venue：Lyon   Country：France  

  • Anti-AQP4 antibody-independent astrocytopathy with extensive connexin loss in Balo’s concentric sclerosis and allied conditions Invited International conference

    2011.4 

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    Language：English   Presentation type：Oral presentation (general)  

    Venue：Hawaii   Country：United States  

  • Pannexin1阻害薬プロベネシドはLATY136F変異マウスの硬膜炎症および線維化を抑制する

    眞﨑勝久

    第32回日本神経免疫学会学術集会  2020.10 

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    Event date： 2020.10

    Language：Japanese  

    Country：Japan  

  • Distinct distribution pattern of microglia and macrophages in concentric lesions of Baló’s disease and neuromyelitis optica spectrum disorders: with special reference to lamellar configuration International conference

    2019.11 

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    Event date： 2019.11

    Language：English  

    Venue：Singapore   Country：Singapore  

  • A novel model of multiple system atrophy-cerebellar type and primary progressive mutlieple sclerosis

    Masaki K, Matsuse D, Yamaguchi H, Saiga T, Nishimura Y, Tanaka T, Watanabe M, Yamasaki R, Tanaka K, Kira J

    2019.11 

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    Event date： 2019.11

    Language：Japanese  

    Country：Japan  

  • Predilection of TMEM119- and GLUT5-Positive Microglia to the Leading Edge of Concentric Lesions of Balo’s Disease and Neuromyelitis Optica Spectrum Disorders International conference

    2019.12 

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    Event date： 2019.10

    Language：English  

    Venue：St. Louis   Country：United States  

  • オリゴデンドロサイト特異的αシヌクレイン蓄積による小脳型多系統萎縮症・一次進行型多発性硬化症モデル

    眞﨑勝久、松瀬大、山口浩雄、雑賀徹、西村由宇慈、田中辰典、渡邉充、田中謙二、山﨑亮、吉良潤一

    第31回日本神経免疫学会学術集会  2019.9 

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    Event date： 2019.9

    Language：Japanese  

    Venue：千葉   Country：Japan  

  • Glial Pathology in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Invited

    Katsuhisa Masaki

    2019.8 

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    Event date： 2019.8

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Host cell-specific TDP-43 proteinopathy and aggresomes by Theiler's murine encephalomyelitis virus

    Katsuhisa Masaki

    2018.5 

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    Event date： 2019.8

    Language：English  

    Country：Japan  

  • Neuropathological Study of Glucose and Lactate Transporters in Demyelinating Disorders

    Katsuhisa Masaki

    The 55th Annual Meeting of the Japanese Society of Neurology  2014.5 

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    Event date： 2019.8

    Language：English  

    Country：Japan  

  • 脱髄性疾患におけるConnexin 43脱落は病態の急速な進行およびdistal oligodendrogliopathy型脱髄と関連する

    眞﨑勝久

    第55回日本神経病理学会総会学術研究会  2014.6 

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    Event date： 2019.8

    Language：Japanese  

    Country：Japan  

  • Neuropathological Study of Glucose and Monocarboxylate Transporters in Multiple Sclerosis International conference

    Katsuhisa Masaki

    The 30th ECTRIMS  2014.9 

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    Event date： 2019.8

    Language：English  

    Country：Japan  

  • Neuropathological Study of Glucose and Lactate Transporters in Demyelinating Disorders

    2014.10 

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    Event date： 2019.8

    Language：Japanese  

    Country：Japan  

  • 多発性硬化症、視神経脊髄炎におけるグルコース・乳酸担体の神経病理学的検討

    眞﨑勝久

    第56回日本神経学会学術大会  2015.5 

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    Event date： 2019.8

    Language：Japanese  

    Country：Japan  

  • 多発性硬化症、視神経脊髄炎におけるグルコース・乳酸担体の神経病理学的検討

    眞﨑勝久

    第27回日本神経免疫学会学術集会  2015.9 

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    Event date： 2019.8

    Language：Japanese  

    Country：Japan  

  • Extensive loss of astrocytic monocarboxylate transporter 4 in demyelinating diseases

    Katsuhisa Masaki

    2016.5 

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    Event date： 2019.8

    Language：English  

    Country：Japan  

  • Extensive loss of astrocytic monocarboxylate transporter 4 in multiple sclerosis and neuromyelitis optica

    Katsuhisa Masaki

    2016.8 

    　More details

    Event date： 2019.8

    Language：English  

    Country：Japan  

  • Glucose and Monocarboxylate Transporters in Early and Extensive Lesions of MS and NMO

    Katsuhisa Masaki

    2016.9 

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    Event date： 2019.8

    Language：English  

    Country：Japan  

  • Immunopathological Study of Glucose and Lactate Transporters in White and Gray Matter Lesions of Multiple Sclerosis and Neuromyelitis Optica International conference

    Katsuhisa Masaki

    141st Annual Meeting of American Neurological Association (ANA)  2016.10 

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    Event date： 2019.8

    Language：English  

    Country：Japan  

  • タイラーウイルス研究から考える脱髄と神経細胞障害

    眞﨑勝久

    第567回脳研カンファレンス  2019.7 

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    Event date： 2019.7 - 2019.8

    Language：Japanese  

    Country：Japan  

  • Up-regulation of connexin 43 in astrocytes and dural fibroblasts in hypertrophic pachymeningitis

    Katsuhisa Masaki

    2019.5 

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    Event date： 2019.5

    Language：English  

    Country：Japan  

  • バロー病と視神経脊髄炎の層状脱髄巣における特異的なTMEM119陽性ミクログリアの分布

    眞﨑勝久

    第60回日本神経学会学術大会  2019.5 

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    Event date： 2019.5

    Language：Japanese  

    Country：Japan  

  • Host cell-specific TDP-43 proteinopathy and aggresomes in Theiler’s murine encephalomyelitis virus infection International conference

    2018.4 

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    Event date： 2018.4

    Language：English  

    Country：United States  

  • Connexin astrocytopathy in multiple sclerosis, Baló’s disease and neuromyelitis optica International conference

    2012.10 

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    Event date： 2012.10

    Language：English  

    Venue：Boston   Country：United States  

  • Connexin astrocytopathy in multiple sclerosis, Baló’s concentric sclerosis and neuromyelitis optica in Asians International conference

    2012.6 

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    Event date： 2012.6

    Language：English  

    Venue：Melbourne   Country：Australia  

  • Extensive Aquaporin-4 (AQP4) Loss in Baló’s Concentric Sclerosis in the Absence of Anti-AQP4 Antibody International conference

    2010.8 

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    Event date： 2010.8

    Language：English  

    Country：Indonesia  

  • 脱髄性疾患におけるConnexin 43脱落は病態の急速な進行およびdistal oligodendrogliopathy型脱髄と関連する.

    眞﨑 勝久

    第25回日本神経免疫学会学術集会  2013.11 

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    Language：Japanese  

    Country：Japan  

  • Balo病における抗AQP4抗体非依存性コネキシンアストロサイトパチー

    眞﨑 勝久

    第52回日本神経学会学術大会  2011.5 

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    Language：Japanese  

    Venue：名古屋   Country：Japan  

  • 多発性硬化症、視神経脊髄炎、Balo病におけるコネキシンアストロサイトパチー

    眞﨑 勝久

    第23回日本神経免疫学会学術集会  2011.9 

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    Language：Japanese  

    Venue：東京   Country：Japan  

  • Connexin astrocytopathy in multiple sclerosis, Balo’s concentric sclerosis and neuromyelitis optica in Asians International conference

    2011.10 

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    Language：English  

    Venue：Amsterdam   Country：Netherlands  

  • 多発性硬化症、視神経脊髄炎、Bal&oacute;病における広汎なコネキシン蛋白の脱落と病態への関与 Invited

    眞﨑 勝久

    第53回日本神経学会学術大会  2012.5 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • 脱髄性疾患における広汎なコネキシン脱落と病態への関与

    眞﨑勝久、鈴木諭、松下拓也、松岡健、鈴木万幾子、末長敏彦、田平武、岩城徹、吉良潤一

    第24回日本神経免疫学会学術集会  2012.9 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：長野   Country：Japan  

  • Distal oligodendrogliopathy型脱髄におけるコネキシンアストロサイトパチーの関与

    眞﨑 勝久

    第54回日本神経学会学術大会  2013.5 

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    Language：Japanese  

    Venue：東京   Country：Japan  

  • Connexin gap junction pathology in the SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS). International conference

    Katsuhisa Masaki

    Neuro2013  2013.6 

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    Language：English  

    Country：Japan  

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MISC

  • 多発性硬化症の病態・病理

    眞﨑勝久

    日本臨牀 80 巻 増刊号 5　免疫性神経疾患(第 2 版) ―基礎・臨床の最新知見―   2022.5

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Tumefactive MS・Balo病

    林田翔太郎，眞﨑勝久

    日本臨牀 80 巻 増刊号 5　免疫性神経疾患(第 2 版) ―基礎・臨床の最新知見―   2022.5

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 多発性硬化症

    眞﨑勝久

    臨床免疫・アレルギー科   2022.4

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 多発性硬化症とBaló病の分子免疫病理

    眞﨑勝久

    日本臨床   2021.10

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 同心円・層状病変におけるミクログリア・マクロファージの多様性とその役割：Baló病と視神経脊髄炎の分子病理学的評価から

    林田翔太郎、眞﨑勝久

    日本臨床   2021.10

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Recent advances in understanding connexin gap junction pathology in demyelinating diseases Reviewed

    Masaki K.

    Clin Exp Neuroimmunol   2020.3

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • IgG4関連疾患と肥厚性硬膜炎

    眞﨑勝久、吉良潤一

    脳神経内科   2019.10

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • NMOSDにおけるMCT4

    眞﨑勝久、吉良潤一

    脳神経内科   2018.1

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • アストロサイトパシーとしての脱髄疾患

    林田翔太郎，眞崎勝久，吉良潤一

    Annual Review 神経 2017   2018.1

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Extensive white matter pathology of longitudinally extensive myelitis in neuromyelitis optica

    Hayashida S, Masaki K, Kira J

    Clin Exp Neuroimmunol   2017.2

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 脱髄性疾患の分子免疫病理学

    眞﨑勝久

    2016.6

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Holocord involvement with sparing of the peripheral white matter rim in longitudinally extensive spinal cord lesions of neuromyelitis optica

    Hayashida S, Masaki K, Matsushita T, Watanabe M, Yamasaki R, Murai H, Kira J

    Clinical and Experimental Neuroimmunology   2015.12

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    Language：English  

  • 同心円硬化症 (Baló病) Reviewed

    眞﨑勝久、吉良潤一

    日本臨牀　別冊　免疫症候群(第2版)I   2015.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica.

    2015.10

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 多発性硬化症の神経病理

    眞﨑勝久、吉良潤一

    日本臨牀 増刊号 　免疫性神経疾患   2015.9

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Tumefactive multiple sclerosisとコネキシン

    眞﨑勝久、吉良潤一

    日本臨牀 増刊号 　免疫性神経疾患   2015.9

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Baló病 (同心円硬化症)

    眞﨑勝久、吉良潤一

    日本臨牀 増刊号 　免疫性神経疾患   2015.9

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Lhermitte徴候

    眞﨑勝久、吉良潤一

    脊椎脊髄ジャーナル   2015.4

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • アストロサイトの動態

    眞﨑勝久、吉良潤一

    2014.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 多発性硬化症・視神経脊髄炎の分子神経病理

    眞﨑勝久

    日本臨床   2014.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Baló病の神経病理

    眞﨑勝久

    日本臨床   2014.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Balo病のMRI

    眞﨑勝久

    2014.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 多発性硬化症における神経炎症

    眞﨑勝久、吉良潤一

    Bio Clinica別冊　慢性炎症と疾患   2014.5

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 急性期MS病巣の特徴

    眞﨑勝久

    2014.5

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Connexin pathology in acute multiple sclerosis, Baló's disease and neuromyelitis optica

    2013.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Loss of connexins might cause extensive demyelination in Baló's disease

    2013.6

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Balo病における広汎なコネキシン蛋白の脱落.

    眞﨑勝久

    2012.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • アストロサイトパチーと脳細胞間情報伝達機構の修復戦略

    眞﨑勝久

    臨床神経学   2012.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • OSMSにおけるAQP4の病態意義

    眞﨑勝久

    神経内科   2012.6

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 神経ベーチェット病

    眞﨑勝久、吉良潤一

    EBMに基づく脳神経疾患の基本治療指針   2010.6

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 脱髄疾患の治療　②視神経脊髄炎

    眞﨑勝久、吉良潤一

    2010.3

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 多発性硬化症の抗体治療：NMOを含む

    眞﨑勝久、吉良潤一

    Annual Review神経   2010.1

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Connexin pathology in acute multiple sclerosis, Baló's disease and neuromyelitis optica.

    2013.12

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Loss of connexins might cause extensive demyelination in Baló's disease.

    2013.6

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Professional Memberships

  • 日本神経学会

  • 日本内科学会

  • 日本神経免疫学会

Committee Memberships

  • Councilor   Domestic

    2020.10 - 2025.3   

  • 日本神経学会   代議員   Domestic

    2019.4 - 2021.3   

  • 日本神経学会   多発性硬化症・視神経脊髄炎診療ガイドライン作成委員   Domestic

    2015.4 - 2020.6   

Research Projects

  • ヘミチャネル阻害薬を用いたαシヌクレイン伝播阻止による多系統萎縮症の治療法開発

    Grant number：23K06965  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 新規発見ノド抗体による自己免疫性ノドパチーの中枢及び末梢神経脱髄機序の解明と治療

    Grant number：22H02985  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • グリアコネキシン低分子量イソフォーム発現エキソソームによる脱髄炎の悪化と治療開発

    Grant number：21K07467  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 多系統萎縮症モデルマウスを用いた画期的ミクログリア標的療法の開発

    Grant number：21K07438  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 活性化グリア細胞制御による進行性多発性硬化症および多系統萎縮症の画期的治療法開発

    Grant number：20K07889  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • Indonesian Neuroimmunology Teleconference International coauthorship

    2019.6

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    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • アストログリアコネキシンの脳内免疫系賦活作用の抑制による多発性硬化症治療法の開発

    Grant number：16K09694  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 全ゲノムと免疫病理解析に基づく脱髄性疾患のグリアシンシチウム破綻機序の解明と修復

    Grant number：16H02657  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 筋萎縮性側索硬化症におけるCCR2陽性単球による神経保護機構解明と移植療法の開発

    Grant number：15K09342  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • グリア特異的コネキシンコンディショナルノックアウトによる巨大同心円状脱髄巣の誘導

    Grant number：15K15341  2015 - 2016

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • グリアシンシチウムを介するエネルギー供給機構の破綻による巨大脱髄巣形成機序の解明

    Grant number：26461295  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 海馬自発てんかんモデルにおけるコネキシンを標的とした病態の解明と新規治療法の開発

    Grant number：26461273  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 脱髄性疾患・統合失調症における白質グリア障害の機構解明と画期的治療法の開発

    Grant number：25117012  2013 - 2017

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究（研究領域提案型）

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 保護的ミクログリアの選択的・時限的活性化による多発性硬化症の完全寛解誘導療法開発

    Grant number：25461282  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • コネキシンサイトパチーによる脱髄性疾患の誘導機構の解明と新規分子標的療法の開発

    Grant number：25293204  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • グリア細胞間情報伝達障害からみた脱髄性疾患の病態解明と新規治療法の開発

    Grant number：24790889  2012 - 2013

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

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Class subject

  • ３学年系統医学Ⅱ（神経）　脱髄性疾患

    2023.10 - 2024.3   Second semester

  • 臨床実習Ⅰ・Ⅱ

    2023.4 - 2024.3   Full year

  • 脳・感覚器概論（臨床医学I-①）

    2023.4 - 2023.9   First semester

  • ３学年系統医学Ⅱ（神経）　脱髄性疾患

    2022.10 - 2023.3   Second semester

  • 臨床実習Ⅰ・Ⅱ

    2022.4 - 2023.3   Full year

  • 脳・感覚器概論（臨床医学I-①）

    2022.4 - 2022.9   First semester

  • ３学年系統医学Ⅱ（神経）　脱髄性疾患

    2021.10 - 2022.3   Second semester

  • 臨床実習Ⅰ・Ⅱ

    2021.4 - 2022.3   Full year

  • 脳・感覚器概論（臨床医学I-①）

    2021.4 - 2021.9   First semester

  • 臨床実習Ⅰ・Ⅱ

    2018.4 - 2019.3   Full year

▼display all

Other educational activity and Special note

  • 2019  Special Affairs 

  • 2019  Special Affairs 

  • 2018  Special Affairs 

Outline of Social Contribution and International Cooperation activities

  • 九州大学病院脳神経内科において、神経難病患者の診療とケアに従事している。

Social Activities

  • 福岡市指定難病審査会委員

    2020

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    福岡市指定難病審査会委員

Activities contributing to policy formation, academic promotion, etc.

  • 2018.12 - 2019.11  

    Indonesian Neuroimmunology Teleconferenceへの参加

Travel Abroad

  • 2016.12 - 2018.11

    Staying countory name 1：United States   Staying institution name 1：米国シカゴ大学神経内科

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Neurology

Clinician qualification

  • Specialist

    Japanese Society of Neurology

Year of medical license acquisition

  • 2003

Notable Clinical Activities

  • 多発性硬化症や視神経脊髄炎スペクトラム障害、重症筋無力症などの神経免疫疾患の専門外来を行い、最新治療についても積極的に取り組んでいる。