Updated on 2024/10/02

Information

 

写真a

 
MATOBA TETSUYA
 
Organization
Kyushu University Hospital Angiocardiology Lecturer
School of Medicine Department of Medicine（Joint Appointment）
Title
Lecturer
Contact information
メールアドレス
Tel
0926425360
Profile
Research in vascular biology, clinical cardiology and resuscitation science Education in basic vascular biology, clinical cardiology and resuscitation Clinical practice in interventional cardiology
External link

Degree

  • MD, PhD

Research Interests・Research Keywords

  • Research theme：Effects of lipid-lowering therapy on coronary endothelial dysfunction after coronary stenting

    Keyword：Percutaneous coronary intervention, oxysterol, statin, ezetimibe, PCSK9 inhibitor

    Research period： 2018.4 - 2024.3

  • Research theme：Role of extracellular vesicles in cardiovascular diseases; Development of new therapeutic strategy

    Keyword：exosome, atherosclerosis, myocardial infarction

    Research period： 2017.10 - 2023.3

  • Research theme：Development of real-world database for cardiovascular medicine

    Keyword：Hospital information system, cardiac catheterization, percutaneous coronary intervention, SS-MIX, database

    Research period： 2017.4 - 2027.3

  • Research theme：Development of new therapeutic modality targeting inflammatory monocyte/macrophage in cardiovascular disease

    Keyword：inflammation, monocyte, macrophage, atherosclerosis, acute coronary syndrome

    Research period： 2012.4 - 2019.3

  • Research theme：Roles of oxidized lipids including oxysterols in the development of atherosclerotic cardiovascular disease

    Keyword：atherosclerosis, oxysterol, endothelial function, macrophage

    Research period： 2011.4 - 2025.3

  • Research theme：Monocyte-selective nanoparticle-mediated drug delivery system for treatment of atherosclerotic plaque rupture

    Keyword：atherosclerosis macrophage nanoparticle

    Research period： 2008.4 - 2011.3

Awards

  • 第15回五島雄一郎賞

    2019.7   日本動脈硬化学会  

  • Circulation Journal Best Reviewers Award

    2017.3  

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    学会誌Circulation Journalの査読において顕著に協力した。

  • ATVB Travel Grant

    2008.11   ATVB Travel Grant

  • Young Investigator Award

    2003.3  

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    Identification of Hydrogen Peroxide as an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans

Papers

  • Institutional Characteristics and Prognosis of Acute Myocardial Infarction With Cardiogenic Shock in Japan - Analysis From the JROAD/JROAD-DPC Database.

    Tetsuya Matoba, Kazuo Sakamoto, Michikazu Nakai, Kenzo Ichimura, Masahiro Mohri, Yasuyuki Tsujita, Masao Yamasaki, Yasushi Ueki, Nobuhiro Tanaka, Yohei Hokama, Motoki Fukutomi, Katsutaka Hashiba, Rei Fukuhara, Satoru Suwa, Hirohide Matsuura, Hayato Hosoda, Takahiro Nakashima, Yoshio Tahara, Yoko Sumita, Kunihiro Nishimura, Yoshihiro Miyamoto, Naohiro Yonemoto, Tsukasa Yagi, Eizo Tachibana, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 10 )   1797 - 1805   2021.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circj.CJ-20-0655

  • Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease. Reviewed International journal

    Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    The New England journal of medicine   381 ( 12 )   1103 - 1113   2019.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1056/NEJMoa1904143

  • Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice. International journal

    Masaki Fujiwara, Tetsuya Matoba, Jun-Ichiro Koga, Arihide Okahara, Daiki Funamoto, Kaku Nakano, Hiroyuki Tsutsui, Kensuke Egashira

    Cardiovascular research   115 ( 7 )   1244 - 1255   2019.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/cvr/cvz066

  • Architecture of the Japan Ischemic Heart Disease Multimodal Prospective Data Acquisition for Precision Treatment (J-IMPACT) System.

    Tetsuya Matoba, Takahide Kohro, Hideo Fujita, Masaharu Nakayama, Arihiro Kiyosue, Yoshihiro Miyamoto, Kunihiro Nishimura, Hideki Hashimoto, Yasuaki Antoku, Naoki Nakashima, Kazuhiko Ohe, Hisao Ogawa, Hiroyuki Tsutsui, Ryozo Nagai

    International heart journal   60 ( 2 )   264 - 270   2019.3

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    DOI： 10.1536/ihj.18-113

  • Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models. International journal

    Masaki Tokutome, Tetsuya Matoba, Yasuhiro Nakano, Arihide Okahara, Masaki Fujiwara, Jun-Ichiro Koga, Kaku Nakano, Hiroyuki Tsutsui, Kensuke Egashira

    Cardiovascular research   115 ( 2 )   419 - 431   2019.2

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    DOI： 10.1093/cvr/cvy200

  • Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion: A Role of Serum Oxysterols. International journal

    Katsuya Honda, Tetsuya Matoba, Yoshibumi Antoku, Jun-Ichiro Koga, Ikuyo Ichi, Kaku Nakano, Hiroyuki Tsutsui, Kensuke Egashira

    Arteriosclerosis, thrombosis, and vascular biology   38 ( 4 )   757 - 771   2018.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/ATVBAHA.117.310244

    Other Link： http://atvb.ahajournals.org/lookup/doi/10.1161/ATVBAHA.117.310244

  • Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial. International journal

    Susumu Takase, Tetsuya Matoba, Soichi Nakashiro, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Shunsuke Katsuki, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Mitsutaka Yamamoto, Makoto Usui, Kenji Sadamatsu, Shinji Satoh, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Kensuke Egashira, Kenji Sunagawa

    Arteriosclerosis, thrombosis, and vascular biology   37 ( 2 )   350 - 358   2017.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/ATVBAHA.116.308388

  • Nanoparticle-Mediated Delivery of Pitavastatin Inhibits Atherosclerotic Plaque Destabilization/Rupture in Mice by Regulating the Recruitment of Inflammatory Monocytes Reviewed International journal

    Shunsuke Katsuki, Tetsuya Matoba, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   129 ( 8 )   2014.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/CIRCULATIONAHA.113.002870

  • Anti-inflammatory gene therapy for cardiovascular disease. Reviewed International journal

    Tetsuya Matoba, Kensuke Egashira

    Curr Gene Ther   11 ( 6 )   2011.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    Other Link： http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22023473&retmode=ref&cmd=prlinks

  • Relationship between the number of drugs used during percutaneous coronary intervention and adverse events in patients with chronic coronary syndrome: Analysis of CLIDAS database

    Hitomi, Y; Imai, Y; Kuwabara, M; Oba, Y; Kabutoya, T; Kario, K; Makimoto, H; Kohro, T; Shiraki, E; Akashi, N; Fujita, H; Matoba, T; Miyamoto, Y; Kiyosue, A; Tsujita, K; Nakayama, M; Nagai, R

    IJC HEART & VASCULATURE   54   101507   2024.10   （ ISSN:23529067 eISSN:2352-9067 ）

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    Language：English   Publisher：IJC Heart and Vasculature  

    Background: Polypharmacy is associated with an increased risk of adverse events due to the higher number of drugs used. This is particularly notable in patients with chronic coronary syndrome (CCS), who are known to use a large number of drugs. Therefore, we investigated polypharmacy in patients with CCS, using CLIDAS, a multicenter database of patients who underwent percutaneous coronary intervention. Method and results: Between 2017 and 2020, 1411 CCS patients (71.5 ± 10.5 years old; 77.3 % male) were enrolled. The relationship between cardiovascular events occurring during the median follow-up of 514 days and the number of drugs at the time of PCI was investigated. The median number of drugs prescribed was nine. Major adverse cardiovascular events (MACE), defined as cardiovascular death, myocardial infarction, stroke, heart failure, transient ischemic attack, or unstable angina, occurred in 123 patients, and all-cause mortality occurred in 68 patients. For each additional drug, the adjusted hazard ratios for MACE and all-cause mortality increased by 2.069 (p = 0.003) and 1.102 (p = 0.010). The adjusted hazard ratios for MACE and all-cause mortality were significantly higher in the group using nine or more drugs compared to the group using eight or fewer drugs (1.646 and 2.253, both p < 0.001). Conclusion: This study showed that an increase in the number of drugs used for CCS may be associated with MACE and all-cause mortality. In patients with CCS, it might be beneficial to minimize the number of medications as much as possible, while managing comorbidities and using guideline-recommended drugs.

    DOI： 10.1016/j.ijcha.2024.101507

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  • Achievement of guideline-recommended target blood pressure is associated with reducing the risk of hemorrhagic and ischemic stroke in Japanese coronary artery disease patients -the CLIDAS study-

    Oba, Y; Kabutoya, T; Kohro, T; Imai, Y; Kario, K; Sato, H; Nochioka, K; Nakayama, M; Akashi, N; Fujita, H; Mizuno, Y; Kiyosue, A; Iwai, T; Miyamoto, Y; Nakano, Y; Ishii, M; Nakamura, T; Tsujita, K; Matoba, T; Nagai, R

    HYPERTENSION RESEARCH   2024.9   （ ISSN:0916-9636 eISSN:1348-4214 ）

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    Language：English   Publisher：Hypertension Research  

    The Japanese Society of Hypertension have established a blood pressure (BP) target of 130/80 mmHg for patients with coronary artery disease (CAD). We evaluated the data of 8793 CAD patients in the Clinical Deep Data Accumulation System database who underwent cardiac catheterization at six university hospitals and the National Cerebral and Cardiovascular Center (average age 70 ± 11 years, 78% male, 43% with acute coronary syndrome [ACS]). Patients were divided into two groups based on whether or not they achieved the guideline-recommended BP of <130/80 mmHg. We analyzed the relationship between BP classification and major adverse cardiac and cerebral event (MACCE) separately in two groups: those with ACS and those with chronic coronary syndrome (CCS). During an average follow-up period of 33 months, 710 MACCEs occurred. A BP below 130/80 mmHg was associated with fewer MACCEs in both the overall (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.70–1.00, p = 0.048) and the ACS group (HR 0.67, 95%CI 0.51–0.88, p = 0.003). In particular, stroke events were also lower among those with a BP below 130/80 mmHg in both the overall (HR 0.69, 95%CI 0.53–0.90, p = 0.006) and ACS groups (HR 0.44, 95%CI 0.30–0.67, p < 0.001). In conclusion, the achievement of BP guidelines was associated with improved outcomes in CAD patients, particularly in reducing stroke risk among those with ACS. (Figure presented.).

    DOI： 10.1038/s41440-024-01902-5

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  • Cyclophilin D induces necrotic core formation by mediating mitochondria-associated macrophage death in advanced atherosclerotic lesions. International journal

    Jun-Ichiro Koga, Ryuta Umezu, Yuki Kondo, Tomohiro Shirouzu, Nasanbadrakh Orkhonselenge, Hiromichi Ueno, Shunsuke Katsuki, Tetsuya Matoba, Yosuke Nishimura, Masaharu Kataoka

    Atherosclerosis   396   118524 - 118524   2024.9   （ ISSN:00219150 ）

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    BACKGROUND AND AIMS: In advanced atherosclerotic lesions, macrophage deaths result in necrotic core formation and plaque vulnerability. Cyclophilin D (CypD) is a mitochondria-specific cyclophilin involved in the process of cell death after organ ischemia-reperfusion. However, the role of CypD in atherosclerosis, especially in necrotic core formation, is unknown. Therefore, this experiment aims to clarify the role of CypD in necrotic core formation. METHODS: To clarify the specific role of CypD, encoded by Ppif in mice, apolipoprotein-E/CypD-double knockout (Apoe-/-Ppif-/-) mice were generated. These mice were fed a high-fat diet containing 0.15 % cholesterol for 24 weeks to accelerate atherosclerotic lesion development. RESULTS: Deletion of CypD decreased the necrotic core size, accompanied by a reduction of macrophage apoptosis compared to control Apoe-/- mice. In RAW264.7 cells, siRNA-mediated knockdown of CypD attenuated the release of cytochrome c from the mitochondria to the cytosol induced by endoplasmic reticulum stress inducer thapsigargin. In addition, necroptosis, induced by TNF-α and caspase inhibitor, was attenuated by knockdown of CypD. Ly-6Chigh inflammatory monocytes in peripheral blood leukocytes and mRNA expression of Il1b in the aorta were decreased by deletion of CypD. In contrast, siRNA-mediated knockdown of CypD did not significantly decrease Il1b nor Ccl2 mRNA expression in RAW264.7 cells treated with LPS and IFN-γ, suggesting that inhibition of inflammation in vivo is likely due to decreased cell death in the atherosclerotic lesions rather than a direct action of CypD deletion on the macrophage. CONCLUSIONS: These results indicate that CypD induces macrophage death and mediates necrotic core formation in advanced atherosclerotic lesions. CypD could be a novel therapeutic target for treating atherosclerotic vascular diseases.

    DOI： 10.1016/j.atherosclerosis.2024.118524

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  • Corrigendum to “Impact of heart failure severity and major bleeding events after percutaneous coronary intervention on subsequent major adverse cardiac events” [Int. J. Cardiol. Cardiovasc. Risk and Prev. 2023 Jun 25:18:200193] (International Journal of Cardiology Cardiovascular Risk and Prevention (2023) 18, (S2772487523000260), (10.1016/j.ijcrp.2023.200193))

    So Ikebe, Masanobu Ishii, Yasuhiro Otsuka, Taishi Nakamura, Kenichi Tsujita, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoshihiro Miyamoto, Hisahiko Sato, Naoyuki Akashi, Hideo Fujita, Ryozo Nagai

    International Journal of Cardiology: Cardiovascular Risk and Prevention   22   200304   2024.9   （ ISSN:2772-4875 eISSN:2772-4875 ）

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    The authors regret that the original version of the article incorrectly stated the study period as “April 2014 to March 2020" in both the Abstract and the Methods section. The correct study period should have been “April 2013 to March 2019". The authors would like to apologise for any inconvenience caused.

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  • Left-digit bias in out-hospital cardiac arrest: The JCS-ReSS study. International journal

    Takahiro Suzuki, Atsushi Mizuno, Daisuke Yoneoka, Takahiro Nakashima, Tetsuya Matoba, Koichi Node, Naohiro Yonemoto, Yoshio Tahara, Yoshio Kobayashi, Takanori Ikeda

    PloS one   19 ( 8 )   e0305577   2024.8   （ ISSN:1932-6203 ）

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    INTRODUCTION: The left-digit bias (LDB), a numerical-related cognitive bias, not only potentially influences decision-making among the general public but also that of medical practitioners. Few studies have investigated its role in out-of-hospital cardiac arrest (OHCA). METHODS: We retrospectively included all consecutive patients with OHCA witnessed by family members registered in the All-Japan Utstein Registry of the Fire and Disaster Management Agency between January 1, 2005, and December 31, 2020. Target outcomes were the percentage of bystander cardiopulmonary resuscitation (BCPR) performed by family members or paramedics and the percentage of prehospital physician-staffed advanced cardiac life support (ACLS). Using a nonparametric regression discontinuity methodology, we examined whether a significant change occurred in the percentages of BCPR and ACLS at the age thresholds of 60, 70, 80, and 90 years, which would indicate the presence of LDB. RESULTS: Of the 1,930,273 OHCA cases in the All-Japan Utstein Registry, 384,200 (19.9%) cases witnessed by family members were analyzed. The mean age was 75.8 years (±SD 13.7), with 38.0% (n = 146,137) female. We identified no discontinuities in the percentages of chest compressions, mouth-to-mouth ventilation, or automated external defibrillator (AED) usage by family members for the age thresholds of 60, 70, 80, and 90 years. Moreover, no discontinuities existed in the percentages of chest compressions, advanced airway management, and AED usage by paramedics or prehospital ACLS by physicians for any of the age thresholds. CONCLUSIONS: In conclusion, our study did not find any evidence that age-related LDB affects medical decision-making in patients with OHCA.

    DOI： 10.1371/journal.pone.0305577

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  • Change in pulse pressure and cardiovascular outcomes after percutaneous coronary intervention: The CLIDAS study

    Kotaro Nochioka, Masaharu Nakayama, Naoyuki Akashi, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Takamasa Iwai, Yoshihiro Miyamoto, Masanobu Ishii, Taishi Nakamura, Kenichi Tsujita, Hisahiko Sato, Hideo Fujita, Ryozo Nagai

    IJC Heart &amp; Vasculature   53   101430 - 101430   2024.8   （ ISSN:2352-9067 eISSN:2352-9067 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ijcha.2024.101430

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  • EVs-miR-17-5p attenuates the osteogenic differentiation of vascular smooth muscle cells potentially via inhibition of TGF-β signaling under high glucose conditions. International journal

    Isashi Baba, Tetsuya Matoba, Shunsuke Katsuki, Jun-Ichiro Koga, Takuro Kawahara, Mitsukuni Kimura, Hidetaka Akita, Hiroyuki Tsutsui

    Scientific reports   14 ( 1 )   16323 - 16323   2024.7   （ ISSN:2045-2322 ）

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    Vascular calcification, which is a major complication of diabetes mellitus, is an independent risk factor for cardiovascular disease. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is one of the key mechanisms underlying vascular calcification. Emerging evidence suggests that macrophage-derived extracellular vesicles (EVs) may be involved in calcification within atherosclerotic plaques in patients with diabetes mellitus. However, the role of macrophage-derived EVs in the progression of vascular calcification is largely unknown. In this study, we investigated whether macrophage-derived EVs contribute to the osteogenic differentiation of VSMCs under high glucose conditions. We isolated EVs that were secreted by murine peritoneal macrophages under normal glucose (EVs-NG) or high glucose (EVs-HG) conditions. miRNA array analysis in EVs from murine macrophages showed that miR-17-5p was significantly increased in EVs-HG compared with EVs-NG. Prediction analysis with miRbase identified transforming growth factor β receptor type II (TGF-β RII) as a potential target of miR-17-5p. EVs-HG as well as miR-17-5p overexpression with lipid nanoparticles inhibited the gene expression of Runx2, and TGF-β RII. Furthermore, we demonstrated that VSMCs transfected with miR-17-5p mimic inhibited calcium deposition. Our findings reveal a novel role of macrophage-derived EVs in the negative regulation of osteogenic differentiation in VSMCs under high glucose conditions.

    DOI： 10.1038/s41598-024-67006-9

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  • Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation

    Yamaguchi, M; Nakao, S; Arima, M; Little, K; Singh, A; Wada, I; Kaizu, Y; Zandi, S; Garweg, JG; Matoba, T; Shiraishi, W; Yamasaki, R; Shibata, K; Go, Y; Ishibashi, T; Uemura, A; Stitt, AW; Sonoda, KH

    DIABETOLOGIA   2024.7   （ ISSN:0012-186X eISSN:1432-0428 ）

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    Language：English   Publisher：Diabetologia  

    Aims/hypothesis: Diabetic retinopathy is characterised by neuroinflammation that drives neuronal and vascular degenerative pathology, which in many individuals can lead to retinal ischaemia and neovascularisation. Infiltrating macrophages and activated retina-resident microglia have been implicated in the progression of diabetic retinopathy, although the distinct roles of these immune cells remain ill-defined. Our aim was to clarify the distinct roles of macrophages/microglia in the pathogenesis of proliferative ischaemic retinopathies. Methods: Murine oxygen-induced retinopathy is commonly used as a model of ischaemia-induced proliferative diabetic retinopathy (PDR). We evaluated the phenotype macrophages/microglia by immunostaining, quantitative real-time RT-PCR (qRT-PCR), flow cytometry and scRNA-seq analysis. In clinical imaging studies of diabetic retinopathy, we used optical coherence tomography (OCT) and OCT angiography. Results: Immunostaining, qRT-PCR and flow cytometry showed expression levels of M1-like macrophages/microglia markers (CD80, CD68 and nitric oxide synthase 2) and M2-like macrophages/microglia markers (CD206, CD163 and macrophage scavenger receptor 1) were upregulated in areas of retinal ischaemia and around neo-vessels, respectively. scRNA-seq analysis of the ischaemic retina revealed distinct ischaemia-related clusters of macrophages/microglia that express M1 markers as well as C-C chemokine receptor 2. Inhibition of Rho-kinase (ROCK) suppressed CCL2 expression and reduced CCR2-positive M1-like macrophages/microglia in areas of ischaemia. Furthermore, the area of retinal ischaemia was reduced by suppressing blood macrophage infiltration not only by ROCK inhibitor and monocyte chemoattractant protein-1 antibody but also by GdCl3. Clinical imaging studies of diabetic retinopathy using OCT indicated potential involvement of macrophages/microglia represented by hyperreflective foci in areas of reduced perfusion. Conclusions/interpretation: These results collectively indicated that heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation in retinal vascular diseases including diabetic retinopathy. This adds important new information that could provide a basis for a more targeted, cell-specific therapeutic approach to prevent progression to sight-threatening PDR. Graphical Abstract: (Figure presented.).

    DOI： 10.1007/s00125-024-06215-3

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  • Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on the Severity and the Mortality of Acute Myocardial Infarction in Japan　— Analysis From the JROAD-DPC Database —

    Kimura Mitsukuni, Matoba Tetsuya, Nakano Yasuhiro, Katsuki Shunsuke, Sakamoto Kazuo, Nishihara Masaaki, Nagata Takuya, Tahara Yoshio, Nagao Ken, Okura Hiroyuki, Ikeda Takanori, Nakai Michikazu, Tsutsui Hiroyuki

    Circulation Reports   6 ( 6 )   191 - 200   2024.6   （ eISSN:24340790 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Circulation Society  

    <p><b><i>Background:</i></b> Coronavirus disease 2019 (COVID-19) has impacted on cardiovascular disease. However, it remains unclear whether the COVID-19 pandemic has impacted on disease severity and patients’ prognosis of acute myocardial infarction (AMI) in Japan.</p><p><b><i>Methods and Results:</i></b> We retrospectively accumulated data from the Japanese Registry of All Cardiac and Vascular Diseases–Diagnosis Procedure Combination (JROAD-DPC) study (April 2019 to March 2021). Patients were divided into a before COVID-19 pandemic group or a during COVID-19 pandemic group. The proportion of patients who presented with cardiogenic shock (Killip class IV) was compared between groups, in association with 30-day mortality as the primary outcome. Killip class IV AMI significantly increased in the during COVID-19 pandemic group (15.7% vs. 14.5% in the before pandemic group, P<0.0001). The 30-day mortality was higher in the during COVID-19 pandemic group (9.6% vs. 9.2% in the before COVID-19 pandemic group, P=0.049). However, there was no significant difference in the adjusted 30-day mortality in each Killip class between the before and during COVID-19 pandemic groups.</p><p><b><i>Conclusions:</i></b> During the early stage of the COVID-19 pandemic in Japan, 30-day mortality of AMI increased, mainly because of the increase of Killip class IV AMI patients. However, irrespective of the COVID-19 pandemic, the adjusted 30-day mortality of each Killip classification group was unchanged.</p>

    DOI： 10.1253/circrep.cr-24-0011

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  • Antithrombotic therapy for stable coronary artery disease and atrial fibrillation in patients with and without revascularisation: the AFIRE trial. International journal

    Takashi Noda, Kotaro Nochioka, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, Satoshi Yasuda, On Behalf Of The Afire Investigators

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology   20 ( 7 )   e425-e435 - E435   2024.4   （ ISSN:1774-024X eISSN:1969-6213 ）

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    BACKGROUND: The Atrial Fibrillation and Ischemic Events with Rivaroxaban in Patients with Stable Coronary Artery Disease (AFIRE) trial demonstrated non-inferior efficacy endpoints for rivaroxaban monotherapy versus combination therapy (rivaroxaban plus a single antiplatelet) and superior safety endpoints in patients with atrial fibrillation and stable coronary artery disease. AIMS: This post hoc analysis investigated whether the AFIRE trial results reflected the presence or absence of prior revascularisation. METHODS: Among 2,215 patients, 1,697 (76.6%) had previously undergone revascularisation, and the remaining 518 (23.4%) had not undergone prior revascularisation. The primary efficacy endpoint was a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularisation, or death from any cause, while the primary safety endpoint was major bleeding. RESULTS: In 1,697 patients with prior revascularisation, the efficacy and safety endpoints were superior for monotherapy versus combination therapy (efficacy: hazard ratio [HR] 0.62, 95% confidence interval [CI]: 0.45-0.85; p=0.003; safety: HR 0.62, 95% CI: 0.39-0.98; p=0.042). Among 518 without prior revascularisation, there were no significant differences in endpoints (efficacy: HR 1.19, 95% CI: 0.67-2.12; p=0.554; safety: HR 0.47, 95% CI: 0.18-1.26; p=0.134). There was borderline interaction of the efficacy endpoints (p=0.055) between two treatments. The safety benefit of monotherapy on any bleeding was significant in patients without prior revascularisation (HR 0.59, 95% CI: 0.38-0.93; p=0.022). CONCLUSIONS: In high-risk thrombosis patients with a history of prior revascularisation, rivaroxaban monotherapy versus combination therapy demonstrated favourable safety and efficacy outcomes.

    DOI： 10.4244/EIJ-D-23-00396

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  • Analysis of the Relationship between Stroke and Cardiovascular Disease Using the Clinical Deep Data Accumulation System(CLIDAS) Database(タイトル和訳中)

    Kuwabara Masanari, Kohro Takahide, Fujita Hideo, Matoba Tetsuya, Sato Hisahiko, Kiyosue Arihiro, Mizuno Yoshiko, Nochioka Kotaro, Nakayama Masaharu, Iwai Takamasa, Miyamoto Yoshihiro, Ishii Masanobu, Nakamura Taishi, Tsujita Kenichi, Akashi Naoyuki, Makimoto Hisaki, Ohba Yusuke, Kabutoya Tomoyuki, Imai Yasushi, Nagai Ryozo

    日本循環器学会学術集会抄録集   88回   LBCS3 - 4   2024.3

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  • BNP level predicts bleeding event in patients with heart failure after percutaneous coronary intervention. International journal

    Yasuhiro Otsuka, Masanobu Ishii, So Ikebe, Taishi Nakamura, Kenichi Tsujita, Koichi Kaikita, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Kazuomi Kario, Yasushi Imai, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoshihiro Miyamoto, Hisahiko Sato, Naoyuki Akashi, Hideo Fujita, Ryozo Nagai

    Open heart   10 ( 2 )   2023.12

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    DOI： 10.1136/openhrt-2023-002489

  • Mapping of Purkinje-related ventricular arrhythmias by a multispline catheter with small and close-paired electrodes: Comparison with conventional catheters. International journal

    Susumu Takase, Yasushi Mukai, Kazuhiro Nagaoka, Kiyohiro Ogawa, Shunsuke Kawai, Nobuhiro Honda, Tomomi Nagayama, Takeshi Tohyama, Shujiro Inoue, Kenji Sadamatsu, Hideki Tashiro, Kazuo Sakamoto, Tetsuya Matoba, Akiko Chishaki, Shintaro Kinugawa, Hiroyuki Tsutsui

    Pacing and clinical electrophysiology : PACE   47 ( 1 )   5 - 18   2023.12   （ ISSN:0147-8389 eISSN:1540-8159 ）

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    BACKGROUND: Precise mapping of the Purkinje fiber network is essential in catheter ablation of Purkinje-related ventricular arrhythmias (PrVAs). We sought to evaluate the mapping ability of a multi-spline duodecapolar catheter (PentaRay) for PrVAs. METHODS: Mappings of Purkinje fibers by PentaRay catheters were compared with those by conventional mapping catheters in consecutive patients undergoing catheter ablation of PrVAs from 2015 to 2022. RESULTS: Sixteen PrVAs (7 premature ventricular contractions or non-reentrant fascicular tachycardias [PVCs/NRFTs] and 9 fascicular ventricular tachycardias [FVTs]) were retrospectively studied. In PVCs/NRFTs, earliest preceding Purkinje potentials (PPs) could be recorded by the PentaRay catheters but not by the mapping and ablation catheters in 5 cases. At the earliest PP sites, the precedence from the QRS onset was greater, and the amplitude of the preceding potentials was higher in the PentaRay catheter compared with those in the mapping and ablation catheter (-62.0 ± 42.8 vs. -29.4 ± 34.2 ms, P = 0.02; 0.45 ± 0.43 vs. 0.09 ± 0.08 mV, P = 0.02). In FVTs, late diastolic potentials (P1) were recorded by the PentaRay catheters but not by the mapping and ablation catheters or the linear duodecapolar catheter in 2 cases. The amplitude of P1 was higher in the PentaRay catheter compared with that in the linear duodecapolar catheter and the mapping and ablation catheters (0.72 ± 0.49 vs. 0.17 ± 0.18 vs. 0.27 ± 0.21 mV, P = 0.0006, P = 0.002). The localized critical PPs, defined as the earliest preceding potentials in PVCs/NRFTs and P1 in FVTs, could be recorded in all the patients by the PentaRay catheter. The mapping ability of critical PPs of PrVAs was better with the PentaRay catheter than with the conventional mapping catheters (16/16 vs. 9/16, P = 0.004 by McNemar exact test). CONCLUSIONS: The PentaRay catheter has clinical advantages in mapping of the Purkinje fiber network to reveal critical PPs as ablation targets of PrVAs.

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  • Serum Values of Cholesterol Absorption and Synthesis Biomarkers in Japanese Healthy Subjects: The CACHE Study HEALTHY Analysis

    Ishibashi Yutaka, Yoshida Hiroshi, Kotani Kazuhiko, Akiyama Yusuke, Fujii Hisako, Harada-Shiba Mariko, Ishida Tatsuro, Ishigaki Yasushi, Kabata Daijiro, Kihara Yasuki, Kurisu Satoshi, Masuda Daisaku, Matoba Tetsuya, Matsuki Kota, Matsumura Takeshi, Mori Kenta, Nakagami Tomoko, Nakazato Masamitsu, Taniuchi Satsuki, Ueno Hiroaki, Yamashita Shizuya, Yano Shozo, Yoshida Hisako, Shoji Tetsuo

    Journal of Atherosclerosis and Thrombosis   30 ( 10 )   1336 - 1349   2023.10   （ ISSN:13403478 eISSN:18803873 ）

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    <p> <b>Aim:</b> Blood cholesterol absorption and synthesis biomarkers predict cardiovascular risk. This study aimed to determine the values of serum non-cholesterol sterol markers [lathosterol (Latho), campesterol (Campe), and sitosterol (Sito)] in healthy individuals and factors affecting these markers.</p><p><b>Methods:</b> The CACHE Consortium compiled clinical data, including serum Latho (cholesterol synthesis marker), and Campe and Sito (cholesterol absorption markers), by a gas chromatography method in 2944 individuals. Healthy subjects were selected by excluding those with prior cardiovascular disease, diabetes mellitus, hypertension, chronic kidney disease, familial hypercholesterolemia, sitosterolemia, current smokers, those with low (＜17 kg/m<sup>2</sup>) or high (≥ 30 kg/m<sup>2</sup>) body mass index (BMI), and those with treatment for dyslipidemia or hyperuricemia. Nonlinear regression stratified by sex was used to examine the associations of cholesterol metabolism markers with age, BMI, and serum lipid levels.</p><p><b>Results:</b> Of 479 individuals selected, 59.4% were female; the median age was 48 years in females and 50 years in males. The three markers showed positively skewed distributions, and sex differences were present. Age was associated positively with Latho, inversely with Campe, but not significantly with Sito. BMI was associated positively with Latho, but not significantly with Campe or Sito. High-density lipoprotein cholesterol (HDL-C) was positively associated with Campe and Sito, but not significantly with Latho. Non-HDL-C was positively associated with the three markers.</p><p><b>Conclusion:</b> Our study results in the healthy subjects help to interpret the non-cholesterol sterol markers for cardiovascular risk assessment in patients with cardiovascular risk factors.</p>

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  • Thrombocytopenia as a Bleeding Risk Factor in Atrial Fibrillation and Coronary Artery Disease: Insights From the AFIRE Study

    Raisuke Iijima, Masahide Tokue, Masato Nakamura, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Journal of the American Heart Association   2023.10

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    DOI： 10.1161/JAHA.123.031096

  • Impact of heart failure severity and major bleeding events after percutaneous coronary intervention on subsequent major adverse cardiac events

    So Ikebe, Masanobu Ishii, Yasuhiro Otsuka, Taishi Nakamura, Kenichi Tsujita, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoshihiro Miyamoto, Hisahiko Sato, Naoyuki Akashi, Hideo Fujita, Ryozo Nagai

    International Journal of Cardiology Cardiovascular Risk and Prevention   18   200193 - 200193   2023.9

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    DOI： 10.1016/j.ijcrp.2023.200193

  • 日本人PCI後患者の心不全発症率と生命予後についての解析

    清末 有宏, 水野 由子, 都島 健介, 明石 直之, 藤田 英雄, 甲谷 友幸, 今井 靖, 苅尾 七臣, 後岡 広太郎, 中山 雅晴, 興梠 貴英, 宮本 恵宏, 石井 正将, 辻田 賢一, 的場 哲哉, 永井 良三

    日本心臓病学会学術集会抄録   71回   O - 6   2023.9

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  • Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

    Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui

    Nutrients   2023.6

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    DOI： 10.3390/nu15132997

  • クリニカルパスの標準化とその効果

    若田 好史, 山下 貴範, 中熊 英貴, 的場 哲哉, 船越 公太, 戸高 浩司, 岡田 美保子, 中島 直樹, 副島 秀久

    日本医療情報学会春季学術大会プログラム・抄録集   27回   106 - 107   2023.6

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  • Risk prediction score for clinical outcome in atrial fibrillation and stable coronary artery disease

    Masanobu Ishii, Koichi Kaikita, Satoshi Yasuda, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Eiichiro Nishihara, Shinichiro Nakamura, Kunihiko Matsui, Hisao Ogawa, Kenichi Tsujita

    Open Heart   10 ( 1 )   2023.5

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    DOI： 10.1136/openhrt-2023-002292

  • Association of Serum Levels of Cholesterol Absorption and Synthesis Markers with the Presence of Cardiovascular Disease: The CACHE Study CVD Analysis.

    Shunsuke Katsuki, Tetsuya Matoba, Yusuke Akiyama, Hiroshi Yoshida, Kazuhiko Kotani, Hisako Fujii, Mariko Harada-Shiba, Yutaka Ishibashi, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Satoshi Kurisu, Daisaku Masuda, Kota Matsuki, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hisako Yoshida, Hiroyuki Tsutsui, Tetsuo Shoji

    Journal of atherosclerosis and thrombosis   2023.4

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    DOI： 10.5551/jat.64119

  • Executive Summary ― Acute Coronary Syndrome in the Japan Resuscitation Council Guidelines for Resuscitation 2020 ―

    87 ( 6 )   866 - 878   2023.4

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    DOI： 10.1253/circj.cj-23-0096

  • JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction.

    Seiji Hokimoto, Koichi Kaikita, Satoshi Yasuda, Kenichi Tsujita, Masaharu Ishihara, Tetsuya Matoba, Yasushi Matsuzawa, Yoshiaki Mitsutake, Yoshihide Mitani, Toyoaki Murohara, Takashi Noda, Koichi Node, Teruo Noguchi, Hiroshi Suzuki, Jun Takahashi, Yasuhiko Tanabe, Atsushi Tanaka, Nobuhiro Tanaka, Hiroki Teragawa, Takanori Yasu, Michihiro Yoshimura, Yasuhide Asaumi, Shigeo Godo, Hiroki Ikenaga, Takahiro Imanaka, Kohei Ishibashi, Masanobu Ishii, Takayuki Ishihara, Yunosuke Matsuura, Hiroyuki Miura, Yasuhiro Nakano, Takayuki Ogawa, Takashi Shiroto, Hirofumi Soejima, Ryu Takagi, Akihito Tanaka, Atsushi Tanaka, Akira Taruya, Etsuko Tsuda, Kohei Wakabayashi, Kensuke Yokoi, Toru Minamino, Yoshihisa Nakagawa, Shozo Sueda, Hiroaki Shimokawa, Hisao Ogawa

    Circulation journal : official journal of the Japanese Circulation Society   87 ( 6 )   879 - 936   2023.3

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    DOI： 10.1253/circj.CJ-22-0779

  • Impact of Heart Failure Severity and Major Bleeding Events after Percutaneous Coronary Intervention on Subsequent All-cause Death(タイトル和訳中)

    池邉 壮, 石井 正将, 大塚 康弘, 中村 太志, 辻田 賢一, 藤田 英雄, 的場 哲哉, 興梠 貴英, 甲谷 友幸, 苅尾 七臣, 清末 有宏, 水野 由子, 中山 雅晴, 宮本 恵宏, 佐藤 寿彦, 永井 良三

    日本循環器学会学術集会抄録集   87回   PJ035 - 4   2023.3

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  • Changes in Systolic Blood Pressure during Hospitalization and Bleeding Events after Percutaneous Coronary Intervention: Insight from the CLIDAS Database(タイトル和訳中)

    石井 正将, 大塚 康弘, 池邉 壮, 中村 太志, 辻田 賢一, 藤田 英雄, 的場 哲哉, 興梠 貴英, 甲谷 友幸, 苅尾 七臣, 清末 有宏, 水野 由子, 中山 雅晴, 宮本 恵宏, 佐藤 寿彦, 永井 良三

    日本循環器学会学術集会抄録集   87回   OJ54 - 8   2023.3

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  • Beyond LDL:動脈硬化性疾患の残余リスクと闘う!(Role of Oxysterols in Endothelial Dysfunction and Myocardial Ischemia-Reperfusion Injury)

    香月 俊輔, Matoba Tetsuya, Uchikawa Tomoki, Takase Susumu, Koga Jun-Ichiro, Tsutsui Hiroyuki

    日本循環器学会学術集会抄録集   87回   PSY03 - 3   2023.3

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  • Macrophage-derived Exosomes Attenuate Osteogenic Differentiation of VSMCs via the Delivery of miR-X in Hyperglycemic Condition(タイトル和訳中)

    馬場 功士, 的場 哲哉, 香月 俊輔, 古賀 純一郎, 筒井 裕之

    日本循環器学会学術集会抄録集   87回   PJ071 - 6   2023.3

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  • Hyperuricemia predicts increased cardiovascular events in patients with chronic coronary syndrome after percutaneous coronary intervention: A nationwide cohort study from Japan. International journal

    Naoyuki Akashi, Masanari Kuwabara, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoko Nakao, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Masanobu Ishii, Taishi Nakamura, Kenichi Tsujita, Hisahiko Sato, Hideo Fujita, Ryozo Nagai

    Frontiers in cardiovascular medicine   9   1062894 - 1062894   2023.1   （ ISSN:2297-055X ）

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    BACKGROUND: The causal relationship between hyperuricemia and cardiovascular diseases is still unknown. We hypothesized that hyperuricemic patients after percutaneous coronary intervention (PCI) had a higher risk of major adverse cardiovascular events (MACE). METHODS: This was a large-scale multicenter cohort study. We enrolled patients with chronic coronary syndrome (CCS) after PCI between April 2013 and March 2019 using the database from the Clinical Deep Data Accumulation System (CLIDAS), and compared the incidence of MACE, defined as a composite of cardiovascular death, myocardial infarction, and hospitalization for heart failure, between hyperuricemia and non-hyperuricemia groups. RESULTS: In total, 9,936 patients underwent PCI during the study period. Of these, 5,138 patients with CCS after PCI were divided into two group (1,724 and 3,414 in the hyperuricemia and non-hyperuricemia groups, respectively). The hyperuricemia group had a higher prevalence of hypertension, atrial fibrillation, history of previous hospitalization for heart failure, and baseline creatinine, and a lower prevalence of diabetes than the non-hyperuricemia group, but the proportion of men and age were similar between the two groups. The incidence of MACE in the hyperuricemia group was significantly higher than that in the non-hyperuricemia group (13.1 vs. 6.4%, log-rank P < 0.001). Multivariable Cox regression analyses revealed that hyperuricemia was significantly associated with increased MACE [hazard ratio (HR), 1.52; 95% confidential interval (CI), 1.23-1.86] after multiple adjustments for age, sex, body mass index, estimated glomerular filtration rate, left main disease or three-vessel disease, hypertension, diabetes mellitus, dyslipidemia, history of myocardial infarction, and history of hospitalization for heart failure. Moreover, hyperuricemia was independently associated with increased hospitalization for heart failure (HR, 2.19; 95% CI, 1.69-2.83), but not cardiovascular death or myocardial infarction after multiple adjustments. Sensitive analyses by sex and diuretic use, B-type natriuretic peptide level, and left ventricular ejection fraction showed similar results. CONCLUSION: CLIDAS revealed that hyperuricemia was associated with increased MACE in patients with CCS after PCI. Further clinical trials are needed whether treating hyperuricemia could reduce cardiovascular events or not.

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  • Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis.

    Kota Matsuki, Mariko Harada-Shiba, Mika Hori, Masatsune Ogura, Yusuke Akiyama, Hisako Fujii, Yutaka Ishibashi, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Kazuhiko Kotani, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hiroshi Yoshida, Hisako Yoshida, Tetsuo Shoji

    Journal of atherosclerosis and thrombosis   30 ( 9 )   1152 - 1164   2023.1

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    DOI： 10.5551/jat.63899

  • Sex Differences in Long-Term Outcomes in Patients With Chronic Coronary Syndrome After Percutaneous Coronary Intervention ― Insights From a Japanese Real-World Database Using a Storage System ―

    87 ( 6 )   775 - 782   2023.1

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    DOI： 10.1253/circj.cj-22-0653

  • Histologic Diagnosis of Coronary Amyloidosis Using Percutaneous Transluminal Directional Atherectomy. International journal

    Daisuke Yoshida, Toru Hashimoto, Masato Katsuki, Akihito Ishikita, Yusuke Ishikawa, Takeo Fujino, Keisuke Shinohara, Shouji Matsushima, Shintaro Kinugawa, Yasuhiro Nakano, Shunsuke Katsuki, Tetsuya Matoba, Shunji Hayashidani, Hiroyuki Tsutsui

    CJC open   5 ( 1 )   99 - 102   2023.1

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    DOI： 10.1016/j.cjco.2022.11.009

  • Association between Serum Oxysterols and Coronary Plaque Regression during Lipid-Lowering Therapy with Statin and Ezetimibe: Insights from the CuVIC Trial

    Yasuhiro Nakano, Mitsutaka Yamamoto, Tetsuya Matoba, Shunsuke Katsuki, Soichi Nakashiro, Susumu Takase, Yusuke Akiyama, Takuya Nagata, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   2022.12

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    DOI： 10.5551/jat.63507

  • Association between Serum Oxysterols and Coronary Plaque Regression during Lipid-Lowering Therapy with Statin and Ezetimibe: Insights from the CuVIC Trial.

    Yasuhiro Nakano, Mitsutaka Yamamoto, Tetsuya Matoba, Shunsuke Katsuki, Soichi Nakashiro, Susumu Takase, Yusuke Akiyama, Takuya Nagata, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui

    Journal of atherosclerosis and thrombosis   2022.12

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  • Rivaroxaban Monotherapy in Atrial Fibrillation and Stable Coronary Artery Disease Across Body Mass Index Categories. International journal

    2 ( 7 )   882 - 893   2022.12

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    BACKGROUND: The AFIRE (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease) trial showed both noninferiority for efficacy and superiority for safety endpoints of rivaroxaban monotherapy compared with those of rivaroxaban plus antiplatelet therapy (combination therapy) in patients with atrial fibrillation and stable coronary artery disease. OBJECTIVES: This study sought to evaluate outcomes of rivaroxaban monotherapy in those patients across body mass index (BMI) categories. METHODS: Patients were categorized into 4 groups: underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5 to <25 kg/m2), overweight (BMI 25 to <30 kg/m2), and obesity (BMI ≥30 kg/m2). Efficacy (a composite of all-cause death, myocardial infarction, unstable angina requiring revascularization, stroke, or systemic embolism) and safety (major bleeding defined according to International Society on Thrombosis and Haemostasis criteria) were compared between rivaroxaban monotherapy and combination therapy across BMI categories. RESULTS: This study analyzed 2,054 patients with a median age of 75.0 years and CHA2DS2-VASc score of 4. A significant interaction was not observed between BMI categories and effect of monotherapy for efficacy (P = 0.83) and safety (P = 0.07), although monotherapy was superior to combination therapy for efficacy in normal weight (HR: 0.64; 95&#37; CI: 0.44-0.95) and safety in overweight (HR: 0.25; 95&#37; CI: 0.10-0.62), whereas a significant difference in the endpoints was not observed in the other BMI categories. CONCLUSIONS: Rivaroxaban monotherapy had a similar effect on prognosis across all BMI categories in patients with atrial fibrillation and stable coronary artery disease. (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease [AFIRE]; UMIN000016612, NCT02642419).

    DOI： 10.1016/j.jacasi.2022.08.004

  • Issues Related to High-Sensitivity Troponin Assays ― Reply ―

    4 ( 11 )   560 - 561   2022.11

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    DOI： 10.1253/circrep.cr-22-0100

  • 医療DX-市民・臨床・学術・産業・国家が打ち出す電子カルテ改革の展望 電子カルテ診療情報二次利用の現状と次世代医療情報システムへの期待 循環器診療情報を収集するCLIDASデータベース

    的場 哲哉, 仲野 泰啓, 深田 光敬, 藤田 英雄, 甲谷 友幸, 興梠 貴英, 今井 靖, 清末 有宏, 水野 由子, 中山 雅晴, 後岡 広太郎, 宮本 恵宏, 岩永 善高, 中尾 葉子, 岩井 雄大, 石井 正将, 中村 太志, 宇宿 功市郎, 辻田 賢一, 的場 ゆり, 佐藤 寿彦, 筒井 裕之, 永井 良三

    医療情報学連合大会論文集   42回   258 - 258   2022.11

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  • 医療DX-市民・臨床・学術・産業・国家が打ち出す電子カルテ改革の展望 電子カルテ診療情報二次利用の現状と次世代医療情報システムへの期待 循環器診療情報を収集するCLIDASデータベース

    的場 哲哉, 仲野 泰啓, 深田 光敬, 藤田 英雄, 甲谷 友幸, 興梠 貴英, 今井 靖, 清末 有宏, 水野 由子, 中山 雅晴, 後岡 広太郎, 宮本 恵宏, 岩永 善高, 中尾 葉子, 岩井 雄大, 石井 正将, 中村 太志, 宇宿 功市郎, 辻田 賢一, 的場 ゆり, 佐藤 寿彦, 筒井 裕之, 永井 良三

    医療情報学連合大会論文集   42回   258 - 258   2022.11

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  • Rivaroxaban Monotherapy in Patients With Atrial Fibrillation and Coronary Stenting at Multiple Vessels or the Left Main Trunk: The AFIRE Trial Subanalysis. International journal

    Mitsuru Ishii, Masaharu Akao, Satoshi Yasuda, Koichi Kaikita, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Journal of the American Heart Association   11 ( 21 )   e027107   2022.11

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    DOI： 10.1161/JAHA.122.027107

  • Identifying Hyperreflective Foci in Diabetic Retinopathy via VEGF-induced Local Self-Renewal of CX3CR1+ Vitreous Resident Macrophages. International journal

    Muneo Yamaguchi, Shintaro Nakao, Iori Wada, Tetsuya Matoba, Mitsuru Arima, Yoshihiro Kaizu, Mariko Shirane, Keijiro Ishikawa, Takahito Nakama, Yusuke Murakami, Masaharu Mizuochi, Wataru Shiraishi, Ryo Yamasaki, Toshio Hisatomi, Tatsuro Ishibashi, Masabumi Shibuya, Alan W Stitt, Koh-Hei Sonoda

    Diabetes   71 ( 12 )   2685 - 2701   2022.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2337/db21-0247

  • Relationships Among Heart Rate, β-Blocker Dosage, and Prognosis in Patients With Coronary Artery Disease in a Real-World Database Using a Multimodal Data Acquisition System

    87 ( 2 )   336 - 344   2022.10

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circj.cj-22-0314

  • Impact of BNP level in patients with heart failure on major bleeding events after percutaneous coronary intervention

    Otsuka, Y; Ishii, M; Nakamura, T; Tsujita, K; Fujita, H; Matoba, T; Kohro, T; Kabutoya, T; Kario, K; Kiyosue, A; Mizuno, Y; Nakayama, M; Miyamoto, Y; Sato, H; Nagai, R

    EUROPEAN HEART JOURNAL   43   1148 - 1148   2022.10   （ ISSN:0195-668X eISSN:1522-9645 ）

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  • Effect of rivaroxaban monotherapy vs. combination with anti -platelet therapy in patients with atrial fibrillation and stable coronary artery disease across different body mass index categories

    Ishii, M; Kaikita, K; Yasuda, S; Akao, M; Ako, J; Matoba, T; Nakamura, M; Miyauchi, K; Hagiwara, N; Kimura, K; Hirayama, A; Matsui, K; Ogawa, H; Tsujita, K

    EUROPEAN HEART JOURNAL   43   1223 - 1223   2022.10   （ ISSN:0195-668X eISSN:1522-9645 ）

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  • Antithrombotic and proton pump inhibitor co-therapy in patients with atrial fibrillation and stable coronary disease: a post hoc analysis of the AFIRE trial

    Wada, H; Miyauchi, KM; Yasuda, SY; Kaikita, KK; Akao, MA; Ako, JA; Matoba, TM; Nakamura, MN; Hagiwara, NH; Kimura, KK; Hirayama, AH; Matsui, K; Ogawa, HO

    EUROPEAN HEART JOURNAL   43   1377 - 1377   2022.10   （ ISSN:0195-668X eISSN:1522-9645 ）

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  • Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC.

    Kazuo Sakamoto, Tetsuya Matoba, Michikazu Nakai, Yoshio Tahara, Takahiro Nakashima, Hayato Hosoda, Yoshihiro Miyamoto, Kunihiro Nishimura, Yoko Sumita, Tsukasa Yagi, Kenzo Ichimura, Naohiro Yonemoto, Eizo Tachibana, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui

    Heart and vessels   38 ( 2 )   228 - 235   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00380-022-02158-0

  • 心不全合併慢性冠症候群PCI後症例の臨床的特徴に関する性別分析 CLIDASリアルワールドデータベースからの知見

    明石 直之, 藤田 英雄, 的場 哲哉, 興梠 貴英, 甲谷 友幸, 今井 靖, 苅尾 七臣, 清末 有宏, 中山 雅晴, 宮本 恵宏, 中村 太志, 辻田 賢一, 的場 ゆり, 佐藤 寿彦, 永井 良三

    日本心臓病学会学術集会抄録   70回   O - 2   2022.9

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  • Rivaroxaban Underdose for Atrial Fibrillation with Stable Coronary Disease: The AFIRE Trial Findings. International journal

    Hiroyuki Arashi, Junichi Yamaguchi, Nobuhisa Hagiwara, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Thrombosis and haemostasis   122 ( 9 )   1584 - 1593   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/s-0042-1744543

  • Relationship between Diabetes Mellitus and Serum Lathosterol and Campesterol Levels: The CACHE Study DM Analysis.

    Takeshi Matsumura, Yasushi Ishigaki, Tomoko Nakagami, Yusuke Akiyama, Yutaka Ishibashi, Tatsuro Ishida, Hisako Fujii, Mariko Harada-Shiba, Daijiro Kabata, Yasuki Kihara, Kazuhiko Kotani, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Kota Matsuki, Kenta Mori, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hiroshi Yoshida, Hisako Yoshida, Tetsuo Shoji

    Journal of atherosclerosis and thrombosis   30 ( 7 )   735 - 753   2022.9

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    DOI： 10.5551/jat.63725

  • Dietary 7-ketocholesterol exacerbates myocardial ischemia–reperfusion injury in mice through monocyte/macrophage-mediated inflammation

    12 ( 1 )   2022.9

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    Abstract

    Emerging evidence suggests that 7-ketocholesterol (7-KC), one of the most abundant dietary oxysterols, causes inflammation and cardiovascular diseases. Here we show the deteriorating effects of dietary 7-KC on myocardial ischemia–reperfusion (IR) injury and detailed the molecular mechanisms. A high-fat high-cholesterol diet containing 7-KC (7KWD) for 3 weeks increased the plasma 7-KC level compared with high-fat high-cholesterol diet in mice. In wild-type mice but not in CCR2−/− mice, dietary 7-KC increased the myocardial infarct size after IR. Flow cytometry revealed that the ratio of Ly-6Chigh inflammatory monocytes to total monocytes was increased in the 7KWD group. Unbiased RNA sequencing using murine primary macrophages revealed that 7-KC regulated the expression of transcripts related to inflammation and cholesterol biosynthesis. We further validated that in vitro, 7-KC induced endoplasmic reticulum stress, mitochondrial reactive oxygen species production, and nuclear factor-kappa B activation, which are associated with increased mRNA levels of proinflammatory cytokines. Administration of N-acetyl-l-cysteine or siRNA-mediated knockdown of PKR-like endoplasmic reticulum kinase or endoplasmic reticulum oxidase 1α suppressed the levels of 7-KC-induced inflammation. Dietary 7-KC exacerbates myocardial IR injury through monocyte/macrophage-mediated inflammation. Endoplasmic reticulum stress and oxidative stress are involved in the 7-KC-induced proinflammatory response in macrophages.

    DOI： 10.1038/s41598-022-19065-z

  • Rivaroxaban Monotherapy vs Combination Therapy With Antiplatelets on Total Thrombotic and Bleeding Events in Atrial Fibrillation With Stable Coronary Artery Disease: A Post Hoc Secondary Analysis of the AFIRE Trial. International journal

    Ryo Naito, Katsumi Miyauchi, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    JAMA cardiology   7 ( 8 )   787 - 794   2022.8

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    DOI： 10.1001/jamacardio.2022.1561

  • Rivaroxaban Underdose for Atrial Fibrillation with Stable Coronary Disease: The AFIRE Trial Findings

    Hiroyuki Arashi, Junichi Yamaguchi, Nobuhisa Hagiwara, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Thrombosis and Haemostasis   122 ( 9 )   1584 - 1593   2022.8

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/s-0042-1744543

  • Supplemental Oxygen and Acute Myocardial Infarction ― A Systematic Review and Meta-Analysis ―

    4 ( 8 )   335 - 344   2022.8

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circrep.cr-22-0031

  • Prehospital Activation of the Catheterization Laboratory Among Patients With Suspected ST-Elevation Myocardial Infarction Outside of a Hospital ― Systematic Review and Meta-Analysis ―

    2022.7

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circrep.cr-22-0034

  • Analysis of an association between socioeconomic deprivation level and ischemic heart disease mortality in Japan using municipal-specific data

    Tasuku Okui, Tetsuya Matoba, Naoki Nakashima

    Epidemiology and Health   e2022059 - e2022059   2022.7

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    Language：Others   Publishing type：Research paper (scientific journal)  

    DOI： 10.4178/epih.e2022059

  • Systematic Review and Meta-Analysis of Diagnostic Accuracy to Identify ST-Segment Elevation Myocardial Infarction on Interpretations of Prehospital Electrocardiograms.

    Akihito Tanaka, Kunihiro Matsuo, Migaku Kikuchi, Sunao Kojima, Hiroyuki Hanada, Toshiaki Mano, Takahiro Nakashima, Katsutaka Hashiba, Takeshi Yamamoto, Junichi Yamaguchi, Naoki Nakayama, Osamu Nomura, Tetsuya Matoba, Yoshio Tahara, Hiroshi Nonogi

    Circulation reports   4 ( 7 )   289 - 297   2022.7

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    DOI： 10.1253/circrep.CR-22-0002

  • Prehospital Administration of Aspirin and Nitroglycerin for Patients With Suspected Acute Coronary Syndrome ― A Systematic Review ―

    4 ( 10 )   449 - 457   2022.7

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    DOI： 10.1253/circrep.cr-22-0060

  • Impact of Prehospital 12-Lead Electrocardiography and Destination Hospital Notification on Mortality in Patients With Chest Pain - A Systematic Review.

    Takahiro Nakashima, Katsutaka Hashiba, Migaku Kikuchi, Junichi Yamaguchi, Sunao Kojima, Hiroyuki Hanada, Toshiaki Mano, Takeshi Yamamoto, Akihito Tanaka, Kunihiro Matsuo, Naoki Nakayama, Osamu Nomura, Tetsuya Matoba, Yoshio Tahara, Hiroshi Nonogi

    Circulation reports   4 ( 5 )   187 - 193   2022.5

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    DOI： 10.1253/circrep.CR-22-0003

  • Performance of the 0-Hour/1-Hour Algorithm for Diagnosing Myocardial Infarction in Patients With Chest Pain in the Emergency Department ― A Systematic Review and Meta-Analysis ―

    2022.4

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    DOI： 10.1253/circrep.cr-22-0001

  • 大規模精密臨床情報基盤CLIDASと医学的有用性

    的場 哲哉, 仲野 泰啓, 興梠 貴英, 今井 靖, 苅尾 七臣, 藤田 英雄, 明石 直之, 清末 有宏, 水野 由子, 中山 雅晴, 後岡 広太郎, 宮本 恵宏, 辻田 賢一, 永井 良三, 筒井 裕之

    循環器内科   91 ( 4 )   488 - 492   2022.4

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  • Associations among cardiovascular and cerebrovascular diseases: Analysis of the nationwide claims-based JROAD-DPC dataset. International journal

    Michikazu Nakai, Yoshitaka Iwanaga, Yoko Sumita, Shinichi Wada, Haruhiko Hiramatsu, Koji Iihara, Takahide Kohro, Issei Komuro, Tomohiro Kuroda, Tetsuya Matoba, Masaharu Nakayama, Kunihiro Nishimura, Teruo Noguchi, Tadamasa Takemura, Teiji Tominaga, Kazunori Toyoda, Kenichi Tsujita, Satoshi Yasuda, Yoshihiro Miyamoto, Hisao Ogawa

    PloS one   17 ( 3 )   e0264390   2022.3   （ ISSN:1932-6203 ）

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    Cardiovascular and cerebrovascular diseases are frequently interconnected due to underlying pathology involving atherosclerosis and thromboembolism. The aim of this study was to investigate the impact of clinical interactions among cardiovascular and cerebrovascular diseases on patient outcomes using a large-scale nationwide claims-based dataset. Cardiovascular diseases were defined as myocardial infarction, heart failure, atrial fibrillation, and aortic dissection. Cerebrovascular diseases were defined as cerebral infarction, intracerebral hemorrhage, and subarachnoid hemorrhage. This retrospective study included 2,736,986 inpatient records (1,800,255 patients) at 911 hospitals from 2015 to 2016 from Japanese registry of all cardiac and vascular disease-diagnostic procedure combination dataset. Interactions among comorbidities and complications, rehospitalization, and clinical outcomes including in-hospital mortality were investigated. Among hospitalization records that involved cardiovascular disease, 5.9% (32,686 records) had cerebrovascular disease as a comorbidity and 2.1% (11,362 records) included an incident cerebrovascular complication after hospitalization. Cerebrovascular disease as a comorbidity or complication was associated with higher in-hospital mortality than no cerebrovascular disease (adjusted odds ratio (OR) [95% confidence interval]: 1.10 [1.06-1.14], 2.02 [1.91-2.13], respectively). Among 367,904 hospitalization records that involved cerebrovascular disease, 17.7% (63,647 records) had cardiovascular disease listed as comorbidity and 3.3% (11,834 records) as a complication. Only cardiovascular disease as a complication was associated with higher in-hospital mortality (adjusted OR [95% confidence interval]: 1.29 [1.22-1.37]). In addition, in-hospital mortality during rehospitalization due to the other disease was significantly higher than mortality during the hospitalization due to the first disease. In conclusion, substantial associations were observed between cardiovascular and cerebrovascular disease in a large-scale nationwide claims-based dataset; these associations had a significant impact on clinical outcomes. More intensive prevention and management of cardiovascular and cerebrovascular disease might be crucial.

    DOI： 10.1371/journal.pone.0264390

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  • Association of Kidney Function with Serum Levels of Cholesterol Absorption and Synthesis Markers: The CACHE Study CKD Analysis.

    Tetsuo Shoji, Yusuke Akiyama, Hisako Fujii, Mariko Harada-Shiba, Yutaka Ishibashi, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Kazuhiko Kotani, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Kota Matsuki, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hisako Yoshida, Hiroshi Yoshida

    Journal of atherosclerosis and thrombosis   29 ( 12 )   1835 - 1848   2022.3

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    DOI： 10.5551/jat.63311

  • Effects of Door-In to Door-Out Time on Mortality Among ST-Segment Elevation Myocardial Infarction Patients Transferred for Primary Percutaneous Coronary Intervention - Systematic Review and Meta-Analysis.

    Junichi Yamaguchi, Tetsuya Matoba, Migaku Kikuchi, Yuichiro Minami, Sunao Kojima, Hiroyuki Hanada, Toshiaki Mano, Takahiro Nakashima, Katsutaka Hashiba, Takeshi Yamamoto, Akihito Tanaka, Kunihiro Matsuo, Naoki Nakayama, Osamu Nomura, Yoshio Tahara, Hiroshi Nonogi

    Circulation reports   4 ( 3 )   109 - 115   2022.3

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    DOI： 10.1253/circrep.CR-21-0160

  • The impact of kidney function in patients on antithrombotic therapy: a post hoc subgroup analysis focusing on recurrent bleeding events from the AFIRE trial. International journal

    Kunihiko Matsui, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Hisao Ogawa

    BMC medicine   20 ( 1 )   69 - 69   2022.2

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    DOI： 10.1186/s12916-022-02268-6

  • Aspirin versus P2Y12 inhibitors with anticoagulation therapy for atrial fibrillation. International journal

    Hidehira Fukaya, Junya Ako, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Tetsuya Matoba, Masato Nakamra, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Heart (British Cardiac Society)   107 ( 21 )   1731 - 1738   2021.11

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    DOI： 10.1136/heartjnl-2021-319321

  • 標準クリニカルパス(ePath)基盤とICTを用いた臨床業務負担軽減の取組み

    山下 貴範, 末久 弘, 的場 哲哉, 佐藤 寿彦, 横地 常広, 野原 康伸, 若田 好史, 中熊 英貴, 坂本 和生, 古賀 純一郎, 筒井 裕之, 井上 創造, 岡田 美保子, 中島 直樹, 副島 秀久

    医療情報学連合大会論文集   41回   152 - 154   2021.11

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  • 標準クリニカルパス(ePath)基盤とICTを用いた臨床業務負担軽減の取組み

    山下 貴範, 末久 弘, 的場 哲哉, 佐藤 寿彦, 横地 常広, 野原 康伸, 若田 好史, 中熊 英貴, 坂本 和生, 古賀 純一郎, 筒井 裕之, 井上 創造, 岡田 美保子, 中島 直樹, 副島 秀久

    医療情報学連合大会論文集   41回   152 - 154   2021.11

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  • 循環器内科領域における臨床業務負担軽減を目指したICTの活用

    的場 哲哉, 坂本 和生, 古賀 純一郎, 山下 貴規, 佐藤 寿彦, 井上 創造, 副島 秀久, 筒井 裕之, 中島 直樹

    医療情報学連合大会論文集   41回   156 - 156   2021.11

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  • Rivaroxaban Monotherapy in Patients With Atrial Fibrillation After Coronary Stenting: Insights From the AFIRE Trial. International journal

    Tetsuya Matoba, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    JACC. Cardiovascular interventions   14 ( 21 )   2330 - 2340   2021.11

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    DOI： 10.1016/j.jcin.2021.07.045

  • Antithrombotic Therapy for Atrial Fibrillation and Coronary Artery Disease in Patients With Prior Atherothrombotic Disease: A Post Hoc Analysis of the AFIRE Trial International journal

    Yasushi Matsuzawa, Kazuo Kimura, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Journal of the American Heart Association   10 ( 21 )   e020907   2021.10

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    DOI： 10.1161/JAHA.121.020907

  • 動脈硬化性疾患予防ガイドライン2022の方向性:改訂へ向けたトピックス JAS 2017ガイドラインが定義する高リスク二次予防患者の予後と脂質管理 リアルワールドデータベースCLIDASの解析から

    的場 哲哉, 藤田 英雄, 興梠 貴英, 甲谷 友幸, 清末 有宏, 水野 由子, 中山 雅晴, 後岡 広太郎, 宮本 恵宏, 岩永 善高, 中村 太志, 辻田 賢一, 佐藤 寿彦, 筒井 裕之, 永井 良三

    日本動脈硬化学会総会プログラム・抄録集   53回   96 - 96   2021.10

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  • ポストISCHEMIAの冠血行再建術とOMT 冠動脈インターベンション術後の脂質管理と残余リスク

    的場 哲哉, 仲野 泰啓, 香月 俊輔, 古賀 純一郎, 江頭 健輔, 筒井 裕之

    日本動脈硬化学会総会プログラム・抄録集   53回   139 - 139   2021.10

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  • Clinical Outcomes of Rivaroxaban Monotherapy in Heart Failure Patients With Atrial Fibrillation and Stable Coronary Disease: Insights From the AFIRE Trial International journal

    Yoshiyuki Yazaki, Masato Nakamura, Raisuke Iijima, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Circulation   144 ( 17 )   1449 - 1451   2021.10

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    DOI： 10.1161/CIRCULATIONAHA.121.055374

  • Bleeding and Subsequent Cardiovascular Events and Death in Atrial Fibrillation With Stable Coronary Artery Disease: Insights From the AFIRE Trial International journal

    Koichi Kaikita, Satoshi Yasuda, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    Circulation: Cardiovascular Interventions   14 ( 11 )   CIRCINTERVENTIONS120010476   2021.9

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    DOI： 10.1161/CIRCINTERVENTIONS.120.010476

  • Pursuit of Optimal Targeted Temperature Management for Patients With Out-of-Hospital Cardiac Arrest.

    Tetsuya Matoba, Hiroyuki Tsutsui

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 10 )   1849 - 1850   2021.9

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    DOI： 10.1253/circj.CJ-21-0645

  • Extracellular vesicles synchronize cellular phenotypes of differentiating cells. International journal

    Tomohiro Minakawa, Tetsuya Matoba, Fumiyoshi Ishidate, Takahiro K Fujiwara, Sho Takehana, Yasuhiko Tabata, Jun K Yamashita

    Journal of extracellular vesicles   10 ( 11 )   e12147   2021.9

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    DOI： 10.1002/jev2.12147

  • Rivaroxaban monotherapy versus combination therapy according to patient risk of stroke and bleeding in atrial fibrillation and stable coronary disease: AFIRE trial subanalysis. International journal

    Masaharu Akao, Satoshi Yasuda, Koichi Kaikita, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa

    American heart journal   236   59 - 68   2021.6

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    DOI： 10.1016/j.ahj.2021.02.021

  • Nanoparticle‐Mediated Simultaneous Targeting of Mitochondrial Injury and Inflammation Attenuates Myocardial Ischemia‐Reperfusion Injury International journal

    Gentaro Ikeda, Tetsuya Matoba, Ayako Ishikita, Kazuhiro Nagaoka, Kaku Nakano, Jun‐ichiro Koga, Hiroyuki Tsutsui, Kensuke Egashira

    10 ( 12 )   e019521   2021.6

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    Background The opening of mitochondrial permeability transition pore and inflammation cooperatively progress myocardial ischemia-reperfusion (IR) injury, which hampers therapeutic effects of primary reperfusion therapy for acute myocardial infarction. We examined the therapeutic effects of nanoparticle-mediated medicine that simultaneously targets mitochondrial permeability transition pore and inflammation during IR injury. Methods and Results We used mice lacking cyclophilin D (CypD, a key molecule for mitochondrial permeability transition pore opening) and C-C chemokine receptor 2 and found that CypD contributes to the progression of myocardial IR injury at early time point (30-45 minutes) after reperfusion, whereas C-C chemokine receptor 2 contributes to IR injury at later time point (45-60 minutes) after reperfusion. Double deficiency of CypD and C-C chemokine receptor 2 enhanced cardioprotection compared with single deficiency regardless of the durations of ischemia. Deletion of C-C chemokine receptor 2, but not deletion of CypD, decreased the recruitment of Ly-6Chigh monocytes after myocardial IR injury. In CypD-knockout mice, administration of interleukin-1β blocking antibody reduced the recruitment of these monocytes. Combined administration of polymeric nanoparticles composed of poly-lactic/glycolic acid and encapsulating nanoparticles containing cyclosporine A or pitavastatin, which inhibit mitochondrial permeability transition pore opening and monocyte-mediated inflammation, respectively, augmented the cardioprotection as compared with single administration of nanoparticles containing cyclosporine A or pitavastatin after myocardial IR injury. Conclusions Nanoparticle-mediated simultaneous targeting of mitochondrial injury and inflammation could be a novel therapeutic strategy for the treatment of myocardial IR injury.

    DOI： 10.1161/JAHA.120.019521

  • Comparison of Endothelial Dysfunction in Coronary Arteries with Bare Metal and 2nd-Generation Drug-Eluting Stents.

    Yusuke Akiyama, Tetsuya Matoba, Shunsuke Katsuki, Susumu Takase, Soichi Nakashiro, Yasuhiro Nakano, Kensuke Noma, Hiroyuki Tsutsui

    Journal of atherosclerosis and thrombosis   2021.2

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    DOI： 10.5551/jat.61366

  • Influenza and Pneumococcal Vaccination in Coronary Artery Disease.

    Tetsuya Matoba

    Journal of atherosclerosis and thrombosis   2021.2

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    DOI： 10.5551/jat.ED160

  • Nanoparticle-Mediated Delivery of Pitavastatin to Monocytes/Macrophages Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apoe－/－ Mice.

    29 ( 1 )   111 - 125   2021.1

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    AIM: Abdominal aortic aneurysm (AAA) is a lethal and multifactorial disease. To prevent a rupture and dissection of enlarged AAA, prophylactic surgery and stenting are currently available. There are, however, no medical therapies preventing these complications of AAA. Statin is one of the candidates, but its efficacy on AAA formation/progression remains controversial. We have previously demonstrated that nanoparticles (NPs) incorporating pitavastatin (Pitava-NPs)-clinical trials using these nanoparticles have been already conducted-suppressed progression of atherosclerosis in apolipoprotein E-deficient (Apoe－/－) mice. Therefore, we have tested a hypothesis that monocytes/macrophages-targeting delivery of pitavastatin prevents the progression of AAA. METHODS: Angiotensin II was intraperitoneally injected by osmotic mini-pumps to induce AAA formation in Apoe－/－ mice. NPs consisting of poly(lactic-co-glycolic acid) were used for in vivo delivery of pitavastatin to monocytes/macrophages. RESULTS: Intravenously administered Pitava-NPs (containing 0.012 mg/kg/week pitavastatin) inhibited AAA formation accompanied with reduction of macrophage accumulation and monocyte chemoattractant protein-1 (MCP-1) expression. Ex vivo molecular imaging revealed that Pitava-NPs not only reduced macrophage accumulation but also attenuated matrix metalloproteinase activity in the abdominal aorta, which was underpinned by attenuated elastin degradation. CONCLUSION: These results suggest that Pitava-NPs inhibit AAA formation associated with reduced macrophage accumulation and MCP-1 expression. This clinically feasible nanomedicine could be an innovative therapeutic strategy that prevents devastating complications of AAA.

    DOI： 10.5551/jat.54379

  • AMED ePath事業のアウトカム 統合解析報告

    山下 貴範, 若田 好史, 松本 順, 的場 哲哉, 羽藤 慎二, 渡邊 紳一郎, 野原 康伸, 中熊 英貴, 村木 泰子, 末久 弘, 小野 雄生, 岩谷 和法, 古賀 純一郎, 劔 卓夫, 神馬 崇宏, 北村 佳代子, 荒木 千恵子, 西馬 みどり, 中井 真也, 港 洋平, 森山 智彦, 吉田 健一, 砂野 由紀, 片山 洋子, 相原 宏紀, 石川 宏昭, 堀 伸一郎, 河村 進, 吉松 正, 橋根 勝義, 冨田 諒太郎, 門司 恵介, 柏木 英志, 岡田 美保子, 中島 直樹, 副島 秀久

    医療情報学連合大会論文集   40回   160 - 162   2020.11

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  • 標準化された医療情報の臨床研究への活用

    木島 真一, 永富 祐太, 中村 泰三, 坂梨 健二, 船越 公太, 日浅 謙一, 的場 哲哉, 井手 友美, 行実 郁子, 高田 敦史, 山下 貴範, 戸高 浩司, 馬場 英司, 筒井 裕之, 中島 直樹

    医療情報学連合大会論文集   40回   762 - 764   2020.11

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  • Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia-reperfusion injury. International journal

    Arihide Okahara, Jun-Ichiro Koga, Tetsuya Matoba, Masaki Fujiwara, Masaki Tokutome, Gentaro Ikeda, Kaku Nakano, Masaki Tachibana, Tetsuro Ago, Takanari Kitazono, Hiroyuki Tsutsui, Kensuke Egashira

    Scientific reports   10 ( 1 )   14435 - 14435   2020.9

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    DOI： 10.1038/s41598-020-71326-x

  • Standard Export Data Format for Extension Storage of Standardized Structured Medical Information Exchange.

    Masaharu Nakayama, Kazuya Takehana, Takahide Kohro, Tetsuya Matoba, Hiroyuki Tsutsui, Ryozo Nagai

    Circulation reports   2 ( 10 )   587 - 616   2020.9

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    DOI： 10.1253/circrep.CR-20-0077

  • Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury. International journal

    Ryuta Umezu, Jun-Ichiro Koga, Tetsuya Matoba, Shunsuke Katsuki, Lixiang Wang, Nao Hasuzawa, Masatoshi Nomura, Hiroyuki Tsutsui, Kensuke Egashira

    Arteriosclerosis, thrombosis, and vascular biology   40 ( 7 )   e214-e226   2020.7

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    DOI： 10.1161/ATVBAHA.120.314383

    Other Link： https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.314383

  • 電子カルテから多モダリティ循環器診療情報を収集するCLIDASデータベースシステム

    的場 哲哉, 興梠 貴英, 藤田 英雄, 苅尾 七臣, 中山 雅晴, 清末 有宏, 宮本 恵宏, 辻田 賢一, 中島 直樹, 筒井 裕之, 永井 良三

    日本動脈硬化学会総会プログラム・抄録集   52回   257 - 257   2020.7

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  • 電子カルテから多モダリティ循環器診療情報を収集するCLIDASデータベースシステム

    的場 哲哉, 興梠 貴英, 藤田 英雄, 苅尾 七臣, 中山 雅晴, 清末 有宏, 宮本 恵宏, 辻田 賢一, 中島 直樹, 筒井 裕之, 永井 良三

    日本動脈硬化学会総会プログラム・抄録集   52回   257 - 257   2020.7

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  • 老化と動脈硬化-基礎から臨床へ 酸化ステロールの炎症と老化における役割

    的場 哲哉, 古賀 純一郎, 香月 俊輔, 内川 智貴, 馬場 功士, 江頭 健輔, 筒井 裕之

    日本動脈硬化学会総会プログラム・抄録集   52回   139 - 139   2020.7

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  • Clinical characteristics and prognostic factors in acute coronary syndrome patients complicated with cardiogenic shock in Japan: analysis from the Japanese Circulation Society Cardiovascular Shock Registry.

    Kazuo Sakamoto, Tetsuya Matoba, Masahiro Mohri, Yasushi Ueki, Yasuyuki Tsujita, Masao Yamasaki, Nobuhiro Tanaka, Yohei Hokama, Motoki Fukutomi, Katsutaka Hashiba, Rei Fukuhara, Satoru Suwa, Hirohide Matsuura, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao

    Heart and vessels   34 ( 8 )   1241 - 1249   2019.8

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    DOI： 10.1007/s00380-019-01354-9

  • Prognostic value of neurological status on hospital arrival for short-term outcome in patients with cardiovascular shock - Sub-analysis of the Japanese circulation society cardiovascular shock registry ―

    83 ( 6 )   1247 - 1253   2019.5

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    © 2019, Japanese Circulation Society. All rights reserved. Background: Consciousness disturbance is one of the major clinical signs associated with shock state, but its prognostic value has not been previously evaluated in cardiovascular shock patients. We aimed to evaluate the prognostic value of neurological status for 30-day mortality in cardiovascular shock patients without out-of-hospital cardiac arrest (OHCA). Methods and Results: Patients with out-of-hospital onset cardiovascular shock were recruited from the Japanese Circulation Society Shock Registry. Neurological status upon hospital arrival was evaluated using the Japan Coma Scale (JCS). Patients were divided into 4 groups according to the JCS: alert, JCS 0; awake, JCS 1–3 (not fully alert but awake without any stimuli); arousable, JCS 10–30 (arousable with stimulation); and coma JCS 100–300 (unarousable). The primary endpoint was 30-day all-cause death. In total, 700 cardiovascular shock patients without OHCA were assessed. The coma group was associated with a higher incidence of 30-day all-cause death compared with other groups (alert, 15.3&#37;; awake, 24.4&#37;; arousable, 36.8&#37;; coma, 48.5&#37;, P<0.001). Similar trends were observed in etiologically divergent subgroups (acute coronary syndrome, non-ischemic arrhythmia, and aortic disease). On multivariate Cox regression analysis, arousable (hazard ratio [HR], 1.82; 95&#37; CI: 1.16–2.85, P=0.009) and coma (HR, 2.72; 95&#37; CI: 1.76–4.22, P<0.001) (reference: alert) independently predicted 30-day mortality. Conclusions: Neurological status upon hospital arrival was useful to predict 30-day mortality in cardiovascular shock patients without OHCA.

    DOI： 10.1253/circj.CJ-18-1323

  • 【心不全のサイエンス 治療法開発をめざして心臓の謎を解く】(第3章)心疾患・心不全の治療法開発の最前線 循環器疾患に対するドラッグデリバリーシステムの可能性

    的場 哲哉, 古賀 純一郎, 江頭 健輔, 筒井 裕之

    実験医学   37 ( 5 )   788 - 794   2019.3

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    循環器疾患治療の改善はわが国の医学の重要な課題である。急性心筋梗塞の原因病態は冠動脈における動脈硬化性プラークの破綻であり、一方、発症した急性心筋梗塞における問題は早期再灌流療法の効果を妨げる心筋虚血再灌流傷害と梗塞後の左室リモデリングであり、これらの病態に対する薬物療法はun-met medical needsである。筆者らはナノテクノロジーを応用したDDS(ナノDDS)により、動脈硬化、急性心筋梗塞を含む循環器疾患におけるナノ医療の実現をめざしている。本稿ではその背景およびモデル動物における前臨床試験の成果を紹介する。(著者抄録)

  • Prognostic value of neurological status on hospital arrival for short-term outcome in patients with cardiovascular shock - Sub-analysis of the Japanese circulation society cardiovascular shock registry ― Reviewed

    83 ( 6 )   1247 - 1253   2019.1

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    Background: Consciousness disturbance is one of the major clinical signs associated with shock state, but its prognostic value has not been previously evaluated in cardiovascular shock patients. We aimed to evaluate the prognostic value of neurological status for 30-day mortality in cardiovascular shock patients without out-of-hospital cardiac arrest (OHCA). Methods and Results: Patients with out-of-hospital onset cardiovascular shock were recruited from the Japanese Circulation Society Shock Registry. Neurological status upon hospital arrival was evaluated using the Japan Coma Scale (JCS). Patients were divided into 4 groups according to the JCS: alert, JCS 0; awake, JCS 1–3 (not fully alert but awake without any stimuli); arousable, JCS 10–30 (arousable with stimulation); and coma JCS 100–300 (unarousable). The primary endpoint was 30-day all-cause death. In total, 700 cardiovascular shock patients without OHCA were assessed. The coma group was associated with a higher incidence of 30-day all-cause death compared with other groups (alert, 15.3%; awake, 24.4%; arousable, 36.8%; coma, 48.5%, P<0.001). Similar trends were observed in etiologically divergent subgroups (acute coronary syndrome, non-ischemic arrhythmia, and aortic disease). On multivariate Cox regression analysis, arousable (hazard ratio [HR], 1.82; 95% CI: 1.16–2.85, P=0.009) and coma (HR, 2.72; 95% CI: 1.76–4.22, P<0.001) (reference: alert) independently predicted 30-day mortality. Conclusions: Neurological status upon hospital arrival was useful to predict 30-day mortality in cardiovascular shock patients without OHCA.

    DOI： 10.1253/circj.CJ-18-1323

  • Nanoparticle-Mediated Targeting of Pitavastatin to Small Pulmonary Arteries and Leukocytes by Intravenous Administration Attenuates the Progression of Monocrotaline-Induced Established Pulmonary Arterial Hypertension in Rats.

    Ichimura K, Matoba T, Koga JI, Nakano K, Funamoto D, Tsutsui H, Egashira K

    International heart journal   59 ( 6 )   1432 - 1444   2018.10

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    DOI： 10.1536/ihj.17-683

  • Safety, Tolerability, and Pharmacokinetics of NK-104-NP.

    Kaku Nakano, Tetsuya Matoba, Jun-Ichiro Koga, Yushi Kashihara, Masato Fukae, Ichiro Ieiri, Masanari Shiramoto, Shin Irie, Junji Kishimoto, Koji Todaka, Kensuke Egashira

    International heart journal   59 ( 5 )   1015 - 1025   2018.9

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    DOI： 10.1536/ihj.17-555

  • Atrial fibrillation and ischemic events with rivaroxaban in patients with stable coronary artery disease (AFIRE): Protocol for a multicenter, prospective, randomized, open-label, parallel group study. International journal

    Satoshi Yasuda, Koichi Kaikita, Hisao Ogawa, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui

    International journal of cardiology   265   108 - 112   2018.8

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    DOI： 10.1016/j.ijcard.2018.04.131

  • マクロファージ研究の最前線 ミトコンドリアと炎症・動脈硬化

    古賀 純一郎, 梅津 隆太, 的場 哲哉, 江頭 健輔

    日本動脈硬化学会総会プログラム・抄録集   50回   156 - 156   2018.6

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  • 腸管吸収に着目した治療戦略 腸管吸収と血管内皮機能の新たなリンク

    的場 哲哉, 古賀 純一郎, 江頭 健輔, 筒井 裕之

    日本動脈硬化学会総会プログラム・抄録集   50回   165 - 165   2018.6

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  • 動脈硬化性心血管病における酸化ステロールの役割 新規プラークびらん動物モデルにおける検討

    的場 哲哉, 本田 勝也, 古賀 純一郎, 江頭 健輔, 筒井 裕之

    日本動脈硬化学会総会プログラム・抄録集   50回   212 - 212   2018.6

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  • 心原性ショックを伴う急性心筋梗塞の予後に施設特徴が及ぼす影響 JROAD/JROAD-DPCの分析(The impact of institutional characteristics on the prognosis of acute myocardial infarction with cardiogenic shock: Analysis from the JROAD/JROAD-DPC)

    的場 哲哉, 坂本 和生, 立花 栄三, 米本 直裕, 長尾 建

    11   31 - 31   2018.4

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  • Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease

    Tetsuya Matoba, Jun-ichiro Koga, Kaku Nakano, Kensuke Egashira, Hiroyuki Tsutsui

    JOURNAL OF CARDIOLOGY   70 ( 3-4 )   206 - 211   2017.9

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    DOI： 10.1016/j.jjcc.2017.03.005

  • Nanoparticle-Mediated Delivery of Pitavastatin to Monocytes/Macrophages Inhibits Left Ventricular Remodeling After Acute Myocardial Infarction by Inhibiting Monocyte-Mediated Inflammation. Reviewed

    Yajing Mao, Jun-Ichiro Koga, Masaki Tokutome, Tetsuya Matoba, Gentaro Ikeda, Kaku Nakano, Kensuke Egashira

    International heart journal   58 ( 4 )   615 - 623   2017.8

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    DOI： 10.1536/ihj.16-457

  • マクロファージに発現するミトコンドリア形態制御分子Drp1はマウス大腿動脈において血管傷害後の内膜肥厚を促進する

    古賀 純一郎, 梅津 隆太, 的場 哲哉, 王 麗香, 野村 政壽, 江頭 健輔

    日本動脈硬化学会総会プログラム・抄録集   49回   113 - 113   2017.6

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  • Response by takase and matoba to letter regarding article, "ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting The cuvic trial (effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial" Reviewed

    Susumu Takase, Tetsuya Matoba

    Arteriosclerosis, thrombosis, and vascular biology   37 ( 5 )   e54   2017.5

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    DOI： 10.1161/ATVBAHA.117.309301

  • ASSOCIATION BETWEEN PRESENTATION TIME AND SHORT-TERM MORTALITY IN PATIENTS WITH CARDIOGENIC SHOCK COMPLICATING ACUTE CORONARY SYNDROME: FROM JCS SHOCK REGISTRY Reviewed

    Taketo Sonoda, Manabu Ogita, Tetsuya Matoba, Masahiro Mohri, Nobuhiro Tanaka, Yohei Hokama, Motoki Fukutomi, Katsutaka Hashiba, Rei Fukuhara, Yasushi Ueki, Hirohide Matsuura, Satoru Suwa, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   69 ( 11 )   295 - 295   2017.3

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  • CLINICAL CHARACTERISTICS AND IN-HOSPITAL MORTALITY OF VERY ELDERLY PATIENTS WITH CARDIOVASCULAR SHOCK IN JAPAN: THE RESULTS FROM JAPANESE CIRCULATION SOCIETY SHOCK REGISTRY Reviewed

    Ken Onitsuka, Masahiro Mohri, Yasushi Ueki, Satoru Suwa, Hiroshi Takahashi, Yohei Hokama, Nobuhiro Tanaka, Toshiaki Kadokami, Tetsuya Matoba, Rei Fukuhara, Tsukasa Yagi, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   69 ( 11 )   293 - 293   2017.3

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  • Optical Frequency Domain Imaging of Covered Stent-Graft for Pulmonary Artery Pseudoaneurysm After Balloon Pulmonary Angioplasty Reviewed

    9 ( 21 )   2255 - 2256   2016.11

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    DOI： 10.1016/j.jcin.2016.08.022

  • A Translational Study of a New Therapeutic Approach for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Porcine Model Reviewed

    Kenzo Ichimura, Tetsuya Matoba, Kaku Nakano, Masaki Tokutome, Katsuya Honda, Jun-ichiro Koga, Kensuke Egashira

    PLOS ONE   11 ( 9 )   2016.9

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    DOI： 10.1371/journal.pone.0162425

  • Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction. Reviewed International journal

    Ayako Ishikita, Tetsuya Matoba, Gentaro Ikeda, Jun-Ichiro Koga, Yajing Mao, Kaku Nakano, Osamu Takeuchi, Junichi Sadoshima, Kensuke Egashira

    Journal of the American Heart Association   5 ( 7 )   2016.7

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    DOI： 10.1161/JAHA.116.003872

    Other Link： http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27451459&retmode=ref&cmd=prlinks

  • Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation. International journal

    Yasuhiro Nakano, Tetsuya Matoba, Masaki Tokutome, Daiki Funamoto, Shunsuke Katsuki, Gentaro Ikeda, Kazuhiro Nagaoka, Ayako Ishikita, Kaku Nakano, Jun-Ichiro Koga, Kenji Sunagawa, Kensuke Egashira

    Scientific reports   6   29601 - 29601   2016.7

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    DOI： 10.1038/srep29601

    Other Link： http://www.nature.com/articles/srep29601

  • Quantification of coronary flow using dynamic angiography with 320-detector row CT and motion coherence image processing: Detection of ischemia for intermediate coronary stenosis. International journal

    Michinobu Nagao, Yuzo Yamasaki, Takeshi Kamitani, Satoshi Kawanami, Koji Sagiyama, Torahiko Yamanouchi, Yamato Shimomiya, Tetsuya Matoba, Yasushi Mukai, Keita Odashiro, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Akihiro Nishie, Hiroshi Honda

    European journal of radiology   85 ( 5 )   996 - 1003   2016.5

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    DOI： 10.1016/j.ejrad.2016.02.027

  • Knowing the Risks of the Vessels From the Vessels Invited Reviewed International journal

    Tetsuya Matoba

    CIRCULATION JOURNAL   80 ( 4 )   825 - 826   2016.4

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    DOI： 10.1253/circj.CJ-16-0164

  • IMPACT OF ONSET TO BALLOON TIME AND SHORT-TERM MORTALITY IN PATIENTS WITH CARDIOGENIC SHOCK COMPLICATING ACUTE CORONARY SYNDROME TREATED WITH PRIMARY PERCUTANEOUS CORONARY INTERVENTION FROM JCS SHOCK REGISTRY Reviewed

    Hideki Ebina, Matoba Tetsuya, Mohri Masahiro, Tanaka Nobuhiro, Hokama Yohei, Fukutomi Motoki, Hashiba Katsutaka, Fukuhara Rei, Ueki Yasushi, Suwa Satoru, Matsuura Hirohide, Tachibana Eizo, Yonemoto Naohiro, Nagao Ken

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   67 ( 13 )   637 - 637   2016.4

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    DOI： 10.1016/S0735-1097(16)30638-6

  • Characteristics and Predictors of Mortality in Patients With Cardiovascular Shock in Japan - Results From the Japanese Circulation Society Cardiovascular Shock Registry - Reviewed

    Yasushi Ueki, Masahiro Mohri, Tetsuya Matoba, Yasuyuki Tsujita, Masao Yamasaki, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao

    CIRCULATION JOURNAL   80 ( 4 )   852 - 859   2016.4

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    DOI： 10.1253/circj.CJ-16-0125

  • Intratracheal Administration of Prostacyclin Analogue-incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension. International journal

    Satoshi Akagi, Kazufumi Nakamura, Hiromi Matsubara, Megumi Kondo, Daiji Miura, Tetsuya Matoba, Kensuke Egashira, Hiroshi Ito

    Journal of cardiovascular pharmacology   67 ( 4 )   290 - 8   2016.4

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    DOI： 10.1097/FJC.0000000000000352

  • Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice. International journal

    Soichi Nakashiro, Tetsuya Matoba, Ryuta Umezu, Jun-Ichiro Koga, Masaki Tokutome, Shunsuke Katsuki, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    Arteriosclerosis, thrombosis, and vascular biology   36 ( 3 )   491 - 500   2016.3

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    DOI： 10.1161/ATVBAHA.115.307057

  • Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening. International journal

    Gentaro Ikeda, Tetsuya Matoba, Yasuhiro Nakano, Kazuhiro Nagaoka, Ayako Ishikita, Kaku Nakano, Daiki Funamoto, Kenji Sunagawa, Kensuke Egashira

    Scientific reports   6   20467 - 20467   2016.2

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    DOI： 10.1038/srep20467

  • Anti-inflammatory nanoparticle for prevention of atherosclerotic vascular diseases Reviewed

    Jun Ichiro Koga, Tetsuya Matoba, Kensuke Egashira

    Journal of atherosclerosis and thrombosis   23 ( 7 )   757 - 765   2016.1

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    DOI： 10.5551/jat.35113

  • Prognostic Impact of Coronary Revascularization in Acute Coronary Syndrome Patients With Cardiogenic Shock Reviewed

    Kazuo Sakamoto, Tetsuya Matoba, Masahiro Mohri, Nobuhiro Tanaka, Yohei Hokama, Motoki Fukutomi, Katsutaka Hashiba, Rei Fukuhara, Yasushi Ueki, Satoru Suwa, Hirohide Matsuura, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao

    CIRCULATION   132   2015.11

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  • 【虚血性疾患をターゲットにするDDSの新展開】冠動脈疾患に対するナノ粒子・ドラッグデリバリーシステムの開発

    的場 哲哉, 古賀 純一郎, 中野 覚, 江頭 健輔

    30 ( 4 )   299 - 308   2015.9

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    冠動脈疾患、特に急性心筋梗塞は急性期死亡率の高さと慢性期の心不全の原因になることから、その予防および治療の改善はわが国の医学の重要な課題である。急性心筋梗塞で問題となる病態は、冠動脈における動脈硬化性プラークの不安定化と破綻であり、一方、発症した急性心筋梗塞における問題は、早期再灌流療法による心筋梗塞縮小効果を妨げる心筋虚血再灌流傷害である。これらの病態に対する薬物療法はun-met medical needsであり、筆者らはナノ粒子を応用したドラッグデリバリーシステムの応用により、冠動脈疾患を含む心血管病におけるナノ医療の実現を目指している。本稿ではその背景およびモデル動物における前臨床試験の成果を紹介する。(著者抄録)

  • A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model Reviewed

    Kazuhiro Nagaoka, Tetsuya Matoba, Yajing Mao, Yasuhiro Nakano, Gentaro Ikeda, Shizuka Egusa, Masaki Tokutome, Ryoji Nagahama, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    PLOS ONE   10 ( 7 )   2015.7

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    DOI： 10.1371/journal.pone.0132451

  • Delivery of imatinib-incorporated nanoparticles into lungs suppresses the development of monocrotaline-induced pulmonary arterial hypertension.

    Satoshi Akagi, Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Hiromi Matsubara, Aiko Ogawa, Tetsuya Matoba, Kensuke Egashira, Hiroshi Ito

    International heart journal   56 ( 3 )   354 - 9   2015.5

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    DOI： 10.1536/ihj.14-338

  • Delivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Ulmonary Arterial Hypertension Reviewed

    Satoshi Akagi, Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Hiromi Matsubara, Aiko Ogawa, Tetsuya Matoba, Kensuke Egashira, Hiroshi Ito

    International Heart Journal   56 ( 3 )   354 - 359   2015.4

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    DOI： 10.1536/ihj.14-338

  • Chest-Compression-Only Bystander Cardiopulmonary Resuscitation in the 30:2 Compression-to-Ventilation Ratio Era - Nationwide Observational Study -

    Ken Nagao, Hiroshi Nonogi, Naohiro Yonemoto, Singo Furuya, Sigemasa Tani, Naoya Matumoto, Morimasa Talcayama, Shinichi Shirai, Takeshi Kimura, Choukou Genka, Eizo Tachibana, Hiromi Seo, Hideharu Tanaka, Hiromi Seo, Hiroyuki Yokoyama, Kazuo Kimura, Keijiro Saku, Kunio Oota, Mamoru Hase, Migaku Kikuchi, Naoki Shimizu, Satoshi Takeda, Shigeru Kanesaka, Sunao Kojima, Takanori Ikeda, Taku Iwami, Tetsuya Matoba, Toshiaki Mano, Tetsuhisa Kitamura, Yoshihiko Seino, Yoshio Tahara

    CIRCULATION JOURNAL   77 ( 11 )   2742 - 2750   2013.11

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    DOI： 10.1253/circj.CJ-13-0457

  • Mouse models of plaque rupture Reviewed

    Tetsuya Matoba, Kensuke Egashira

    CURRENT OPINION IN LIPIDOLOGY   24 ( 5 )   2013.10

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    DOI： 10.1097/MOL.0b013e3283646e4d

  • Pitavastatin-incorporated nanoparticle-eluting stents attenuate in-stent stenosis without delayed endothelial healing effects in a porcine coronary artery model Reviewed

    Noriaki Tsukie, Kaku Nakano, Tetsuya Matoba, Seigo Masuda, Eiko Iwata, Miho Miyagawa, Gang Zhao, Wei Meng, Junji Kishimoto, Kenji Sunagawa, Kensuke Egashira

    Journal of Atherosclerosis and Thrombosis   20 ( 1 )   32 - 45   2013.2

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    DOI： 10.5551/jat.13862

  • Pitavastatin-incorporated nanoparticle-eluting stents attenuate in-stent stenosis without delayed endothelial healing effects in a porcine coronary artery model. Reviewed International journal

    Noriaki Tsukie, Kaku Nakano, Tetsuya Matoba, Seigo Masuda, Eiko Iwata, Miho Miyagawa, Gang Zhao, Wei Meng, Junji Kishimoto, Kenji Sunagawa, Kensuke Egashira

    J Atheroscler Thromb   20 ( 1 )   32 - 45   2013.1

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  • Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries Therapeutic effects of ezetimibe Reviewed

    Kei Sato, Kaku Nakano, Shunsuke Katsuki, Tetsuya Matoba, Kyoichi Osada, Tatsuya Sawamura, Kenji Sunagawa, Kensuke Egashira

    Journal of atherosclerosis and thrombosis   19 ( 11 )   986 - 998   2012.12

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    DOI： 10.5551/jat.13391

  • Impact with Child and Adolescence on Time of the Chain of Survival in Out-of Hospital Cardiac Arrest from All-Japan Utstein Registry Data Reviewed

    Naohiro Yonemoto, Hiroyuki Yokoyama, Tetsuya Matoba, Ken Nagao, Takeshi Kimura, Nonogi Hiroshi

    CIRCULATION   126 ( 21 )   2012.11

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  • Nanoparticle-Mediated Delivery of Pioglitazone Enhances Therapeutic Neovascularization in a Murine Model of Hindlimb Ischemia Reviewed International journal

    Ryoji Nagahama, Tetsuya Matoba, Kaku Nakano, Kim-Mitsuyama, Kenji Sunagawa, Kensuke Egashira

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   32 ( 10 )   2012.10

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    DOI： 10.1161/ATVBAHA.112.253823

  • Usefulness of non-contact mapping for radiofrequency catheter ablation of inappropriate sinus tachycardia New procedural strategy and long-term clinical outcome Reviewed

    Masao Takemoto, Yasushi Mukai, Shuujirou Inoue, Tetsuya Matoba, Mari Nishizaka, Tomomi Ide, Akiko Chishaki, Kenji Sunagawa

    Internal Medicine   51 ( 4 )   357 - 362   2012.2

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    DOI： 10.2169/internalmedicine.51.5882

  • Imatinib mesylate-incorporated nanoparticle-eluting stent attenuates in-stent neointimal formation in porcine coronary arteries Reviewed

    Seigo Masuda, Kaku Nakano, Kouta Funakoshi, Gang Zhao, Wei Meng, Satoshi Kimura, Tetsuya Matoba, Miho Miyagawa, Eiko Iwata, Kenji Sunagawa, Kensuke Egashira

    Journal of Atherosclerosis and Thrombosis   18 ( 12 )   1043 - 1053   2011.12

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    DOI： 10.5551/jat.8730

  • Time-Dependent Benefit of Biphasic Defibrillators in Patients with Witnessed Out-of-Hospital Cardiac Arrest from VF/Pulseless VT Reviewed

    Soichi Nakashiro, Tetsuya Matoba, Naohiro Yonemoto, Hiroshi Nonogi, Hiromi Seo, Hiroyuki Yokoyama, Ken Nagao, Takeshi Kimura

    CIRCULATION   124 ( 21 )   2011.11

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  • 当院におけるunprotected LMCA病変に対するPCIの治療成績

    得能 智武, 竹本 真生, 的場 哲哉, 江島 健一, 肥後 太基, 砂川 賢二

    日本心臓病学会誌   6 ( Suppl.I )   463 - 463   2011.8

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  • Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension. Reviewed International journal

    Ling Chen, Kaku Nakano, Satoshi Kimura, Tetsuya Matoba, Eiko Iwata, Miho Miyagawa, Hiroyuki Tsujimoto, Kazuhiro Nagaoka, Junji Kishimoto, Kenji Sunagawa, and Kensuke Egashira

    Hypertension   57 ( 2 )   2011.6

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    DOI： 10.1161/HYPERTENSIONAHA.110.157032

    Other Link： http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21220711&retmode=ref&cmd=prlinks

  • Effect of 'Early Defibrillation' on the Survival of Patients With Witnessed Cardiac Arrest From Ventricular Fibrillation in the Guideline 2005 Era in Japan Reviewed

    Tetsuya Matoba, Hiroshi Nonogi, Hiromi Seo, Hiroyuki Yokoyama, Naohiro Yonemoto, Ken Nagao, Takeshi Kimura

    CIRCULATION   122 ( 21 )   2010.11

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  • Nanoparticle-mediated endothelial cell-selective delivery of pitavastatin induces functional collateral arteries (therapeutic arteriogenesis) in a rabbit model of chronic hind limb ischemia. International journal

    Shinichiro Oda, Ryoji Nagahama, Kaku Nakano, Tetsuya Matoba, Mitsuki Kubo, Kenji Sunagawa, Ryuji Tominaga, Kensuke Egashira

    Journal of vascular surgery   52 ( 2 )   412 - 20   2010.8

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    DOI： 10.1016/j.jvs.2010.03.020

    Other Link： http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20573471&retmode=ref&cmd=prlinks

  • Statins in the management of acute coronary syndrome. Invited Reviewed

    Tetsuya Matoba and Kensuke Egashira

    Nippon Rinsho   68 ( 4 )   2010.4

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  • Rotational atherectomy for calcified coronary stenosis in elderly patients with severe left ventricular dysfunction: Three case reports

    Takemoto, M., Shibata, Y., Eshima, K.-I., Mukai, Y., Inoue, S., Sagara, Y., Matoba, T., Tada, H., Sunagawa, K.

    Japanese Journal of Interventional Cardiology   24 ( 2 )   141 - 147   2009.8

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  • Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. International journal

    Kimio Satoh, Patrizia Nigro, Tetsuya Matoba, Michael R O'Dell, Zhaoqiang Cui, Xi Shi, Amy Mohan, Chen Yan, Jun-ichi Abe, Karl A Illig, Bradford C Berk

    Nature medicine   15 ( 6 )   649 - 56   2009.6

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    DOI： 10.1038/nm.1958

    Other Link： http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=19430489

  • Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium. International journal

    Mitsuki Kubo, Kensuke Egashira, Takahiro Inoue, Jun-ichiro Koga, Shinichiro Oda, Ling Chen, Kaku Nakano, Tetsuya Matoba, Yoshiaki Kawashima, Kaori Hara, Hiroyuki Tsujimoto, Katsuo Sueishi, Ryuji Tominaga, Kenji Sunagawa

    Arteriosclerosis, thrombosis, and vascular biology   29 ( 6 )   796 - 801   2009.6

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    DOI： 10.1161/ATVBAHA.108.182584

    Other Link： http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=19325146

  • Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents Reviewed International journal

    Hiasa, Ken-ichi Takemoto, Masao Matsukawa, Ryuichi Matoba, Tetsuya Kuga, Takeshi Sunagawa, Kenji

    Intern Med   48 ( 4 )   2009.4

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    Other Link： http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=19218771

  • Soluble Flt-1 gene transfer ameliorates neointima formation after wire injury in flt-1 tyrosine kinase-deficient mice. International journal

    Jun-ichiro Koga, Tetsuya Matoba, Kensuke Egashira, Mitsuki Kubo, Miho Miyagawa, Eiko Iwata, Katsuo Sueishi, Masabumi Shibuya, Kenji Sunagawa

    Arteriosclerosis, thrombosis, and vascular biology   29 ( 4 )   458 - 64   2009.4

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    DOI： 10.1161/ATVBAHA.109.183772

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  • Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology: efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. International journal

    Kaku Nakano, Kensuke Egashira, Seigo Masuda, Kouta Funakoshi, Gang Zhao, Satoshi Kimura, Tetsuya Matoba, Katsuo Sueishi, Yasuhisa Endo, Yoshiaki Kawashima, Kaori Hara, Hiroyuki Tsujimoto, Ryuji Tominaga, Kenji Sunagawa

    JACC. Cardiovascular interventions   2 ( 4 )   277 - 83   2009.4

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    DOI： 10.1016/j.jcin.2008.08.023

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  • Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents Reviewed

    Hiasa Ken-Ichi, Masao Takemoto, Ryuichi Matsukawa, Tetsuya Matoba, Takeshi Kuga, Kenji Sunagawa

    Internal Medicine   48 ( 4 )   213 - 217   2009.3

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    DOI： 10.2169/internalmedicine.48.1581

  • Essential role of angiotensin II type 1a receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis. International journal

    Jun-ichiro Koga, Kensuke Egashira, Tetsuya Matoba, Mitsuki Kubo, Yoshiko Ihara, Masaru Iwai, Masatsugu Horiuchi, Kenji Sunagawa

    Hypertension research : official journal of the Japanese Society of Hypertension   31 ( 9 )   1791 - 800   2008.9

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    DOI： 10.1291/hypres.31.1791

  • Cyclophilin a mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation Reviewed

    Kimio Satoh, Tetsuya Matoba, Jun Suzuki, Michael R. O'Dell, Patrizia Nigro, Zhaoqiang Cui, Amy Mohan, Shi Pan, Lingli Li, Zheng Gen Jin, Chen Yan, Jun Ichi Abe, Bradford C. Berk

    Circulation   117 ( 24 )   3088 - 3098   2008.6

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    DOI： 10.1161/CIRCULATIONAHA.107.756106

  • 【大動脈解離と大動脈瘤の成因・診断・治療】大動脈瘤の分子メカニズム

    古賀 純一郎, 的場 哲哉, 江頭 健輔

    6 ( 4 )   306,298 - 311,298   2007.12

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    大動脈瘤は、脆弱化した血管壁に血圧、shear stressなどの力学的ストレスが加わり、血管径の拡大をきたす疾患である。血管構造の脆弱化をもたらす機序としては、血管壁に単球・マクロファージを中心とする炎症細胞が浸潤し各種プロテアーゼが活性化される結果、エラスチン線維やコラーゲン線維からなる細胞外基質の分解が生じることが中心であると考えられている。さまざまな心血管病に関わるレニン・アンジオテンシン系(RAS系)も、昇圧作用に加え、炎症を惹起することによりこれらの過程を促進する。(著者抄録)

  • 血管傷害後新生内膜形成の分子機序における血管内皮成長因子受容体(flk-1 versus flt-1)の相対的役割 VEGFはflk-1を介して新生内膜形成を促進する

    古賀 純一郎, 的場 哲哉, 江頭 健輔, 砂川 賢二

    日本高血圧学会総会プログラム・抄録集   30回   198 - 198   2007.10

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  • マウス血管傷害後の新生内膜形成におけるVEGF受容体(flt-1 versus flk-1)の役割解明

    古賀 純一郎, 的場 哲哉, 江頭 健輔, 渋谷 正史, 砂川 賢二

    日本動脈硬化学会総会プログラム・抄録集   39回   257 - 257   2007.6

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  • Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells Reviewed

    Jun Suzuki, Zheng Gen Jin, David F. Meoli, Tetsuya Matoba, Bradford C. Berk

    Circulation research   98 ( 6 )   811 - 817   2006.3

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    DOI： 10.1161/01.RES.0000216405.85080.a6

  • Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease Reviewed

    Yoshihiro Fukumoto, Akira Ito, Toyokazu Uwatoku, Tetsuya Matoba, Takuya Kishi, Haruki Tanaka, Akira Takeshita, Kenji Sunagawa, Hiroaki Shimokawa

    Coronary Artery Disease   17 ( 1 )   63 - 70   2006.2

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    DOI： 10.1097/00019501-200602000-00011

  • Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated responses in mice Reviewed

    Keiko Morikawa, Tetsuya Matoba, Hiroshi Kubota, Makoto Hatanaka, Takako Fujiki, Shosuke Takahashi, Akira Takeshita, Hiroaki Shimokawa

    Journal of Cardiovascular Pharmacology   45 ( 5 )   485 - 490   2005.5

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    DOI： 10.1097/01.fjc.0000159657.93922.cb

  • Endothelium-derived hydrogen peroxide accounts for the enhancing effect of an angiotensin-converting enzyme inhibitor on endothelium-derived hyperpolarizing factor-mediated responses in mice Reviewed

    Takako Fujiki, Hiroaki Shimokawa, Keiko Morikawa, Hiroshi Kubota, Makoto Hatanaka, M. A.Hassan Talukder, Tetsuya Matoba, Akira Takeshita, Kenji Sunagawa

    Arteriosclerosis, thrombosis, and vascular biology   25 ( 4 )   766 - 771   2005.4

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    DOI： 10.1161/01.ATV.0000158498.19027.75

  • Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension Reviewed

    Yoshihiro Fukumoto, Tetsuya Matoba, A. Ito, H. Tanaka, Takuya Kishi, Shunji Hayashidani, Kotaro Abe, A. Takeshita, H. Shimokawa

    Heart   91 ( 3 )   391 - 392   2005.3

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    DOI： 10.1136/hrt.2003.029470

  • Important role of superoxide dismutase in EDHF-mediated responses of human mesenteric arteries Reviewed

    Keiko Morikawa, Takako Fujiki, Tetsuya Matoba, Hiroshi Kubota, Makoto Hatanaka, Shosuke Takahashi, Hiroaki Shimokawa

    Journal of Cardiovascular Pharmacology   44 ( 5 )   552 - 556   2004.11

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    DOI： 10.1097/00005344-200411000-00006

  • Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery. International journal

    Kousuke Inokuchi, Akira Ito, Yoshihiro Fukumoto, Tetsuya Matoba, Akira Shiose, Takahiro Nishida, Munetaka Masuda, Shigeki Morita, Hiroaki Shimokawa

    Journal of cardiovascular pharmacology   44 ( 3 )   275 - 7   2004.9

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    DOI： 10.1097/01.fjc.0000134775.76636.3f

  • Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. International journal

    Keiko Morikawa, Hiroaki Shimokawa, Tetsuya Matoba, Hiroshi Kubota, Takaaki Akaike, M A Hassan Talukder, Makoto Hatanaka, Takako Fujiki, Hiroshi Maeda, Shosuke Takahashi, Akira Takeshita

    The Journal of clinical investigation   112 ( 12 )   1871 - 9   2003.12

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    DOI： 10.1172/JCI200319351

  • Acute vasodilator effects of HMG-CoA reductase inhibitors Involvement of PI3-kinase/Akt pathway and Kv channels Reviewed

    Yasushi Mukai, Hiroaki Shimokawa, Tetsuya Matoba, Junko Hiroki, Ikuko Kunihiro, Takako Fujiki, Akira Takeshita

    Journal of Cardiovascular Pharmacology   42 ( 1 )   118 - 124   2003.7

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    DOI： 10.1097/00005344-200307000-00018

  • Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels. International journal

    Tetsuya Matoba, Hiroaki Shimokawa, Keiko Morikawa, Hiroshi Kubota, Ikuko Kunihiro, Lemmy Urakami-Harasawa, Yasushi Mukai, Yoji Hirakawa, Takaaki Akaike, Akira Takeshita

    Arteriosclerosis, thrombosis, and vascular biology   23 ( 7 )   1224 - 30   2003.7

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    DOI： 10.1161/01.ATV.0000078601.79536.6C

  • Involvement of neuronal NO synthase in NO-cGMP-mediated pathway in the maintenance of bradykinin-induced coronary flow in endothelial NO synthase knockout mice

    MAH Talukder, H Shimokawa, T Fujiki, K Morikawa, H Kubota, T Matoba, A Takeshita

    FASEB JOURNAL   17 ( 4 )   A504 - A504   2003.3

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  • Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats. International journal

    Yasushi Mukai, Hiroaki Shimokawa, Midoriko Higashi, Keiko Morikawa, Tetsuya Matoba, Junko Hiroki, Ikuko Kunihiro, Hassan M A Talukder, Akira Takeshita

    Arteriosclerosis, thrombosis, and vascular biology   22 ( 9 )   1445 - 50   2002.9

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    DOI： 10.1161/01.ATV.0000029121.63691.CE

  • Involvement of Rho-kinase in agonists-induced contractions of arteriosclerotic human arteries Reviewed

    Tadashi Kandabashi, Hiroaki Shimokawa, Yasushi Mukai, Tetsuya Matoba, Ikuko Kunihiro, Keiko Morikawa, Masaaki Ito, Shosuke Takahashi, Kozo Kaibuchi, Akira Takeshita

    Arteriosclerosis, thrombosis, and vascular biology   22 ( 2 )   243 - 248   2002.2

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    DOI： 10.1161/hq0202.104274

  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries Reviewed

    Tetsuya Matoba, Hiroaki Shimokawa, Hiroshi Kubota, Keiko Morikawa, Takako Fujiki, Ikuko Kunihiro, Yasushi Mukai, Yoji Hirakawa, Akira Takeshita

    Biochemical and Biophysical Research Communications   290 ( 3 )   909 - 913   2002.1

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    DOI： 10.1006/bbrc.2001.6278

  • Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.

    Y. Mukai, H. Shimokawa, T. Matoba, T. Kandabashi, S. Satoh, J. Hiroki, K. Kaibuchi, A. Takeshita

    The FASEB journal : official publication of the Federation of American Societies for Experimental Biology   15   1062 - 1064   2001.4

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    Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.

  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice

    T Matoba, H Shimokawa, M Nakashima, Y Hirakawa, Y Mukai, K Hirano, H Kanaide, A Takeshita

    JOURNAL OF CLINICAL INVESTIGATION   106 ( 12 )   1521 - 1530   2000.12

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Presentations

  • Digital Twin for Cardiovascular Medicine Based on the Clinical Deep Data Accumulation System (CLIDAS) Invited International conference

    2024.3 

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    Event date： 2024.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Clinical Deep Data Accumulation System (CLIDAS) reveals Real-World Medical Therapy and Prognosis of Japanese patients after Percutaneous Coronary Intervention International conference

    Tetsuya Matoba 1, H. Fujita 2, T. Kohro 3, T. Kabutoya 4, Y. Ohba 4, Y. Imai 4, K. Kario 4, A. Kiyosue 5, Y. Mizuno 5, M. Nakayama 6, K. Nochioka 6, Y. Miyamoto 7, Y. Iwanaga 7, Y. Nakao 7, T. Iwai 7, K. Tsujita 8, T. Nakamura 9, H. Sato 10, Y. Nakano 1, H. Tsutsui 1, R. Nagai 11 (1) Kyushu University, Cardiovascular Medicine, Fukuoka, Japan; (2) Jichi Medical University Saitama Medical Center, Cardiology, Saitama, Japan; (3) Jichi Medical University, Medical Informatics, Tochigi, Japan; (4) Jichi Medical University, Cardiology, Tochigi, Japan; (5) University of Tokyo Hospital, Cardiology, Tokyo, Japan; (6) Tohoku University Graduate School of Medicine, Medical Informatics, Sendai, Japan; (7) National Cerebral and Cardiovascular Center Hospital, Cerebral and Cardiovascular Disease Information, Osaka, Japan; (8) Kumamoto University Hospital, Cardiovascular Center, Kumamoto, Japan; (9) Kumamoto University Hospital, Medical Informatics, Kumamoto, Japan; (10) Precision, Tokyo, Japan; (11) Jichi Medical University, Tochigi, Japan

    2022.3 

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    Event date： 2022.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Efficacy of microRNA Delivery by Lipid and Polymeric Nanoparticles International conference

    Tetsuya Matoba1, Isashi Baba1, Tomohiro Minakawa2, Yu Sakurai3, Hidetaka Akita3, Jun K. Yamashita2, Hiroyuki Tsutsui1 1 Department of Cardiovascular Medicine, Kyushu University. 2 Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University. 3 Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Science, Chiba University.

    Pacifichem 2021  2021.12 

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    Event date： 2021.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Management of Cardiogenic shock in Acute Myocardial Infarction Invited International conference

    Tetsuya Matoba, Kazuo Sakamoto, Hiroyuki Tsutsui.

    The 19th International Symposium on Atherosclerosis (ISA 2021)  2021.10 

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    Event date： 2021.10

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • JAS 2017ガイドラインが定義する高リスク二次予防患者の予後と脂質管理―リアルワールドデータベースCLIDASの解析から― Invited

    的場哲哉1, 藤田英雄2, 興梠貴英2, 甲谷友幸2, 清末有宏3, 水野由子3, 中山雅晴4, 後岡広太郎4, 宮本恵宏5, 岩永善高5, 中村太志6, 辻田賢一6, 佐藤寿彦7, 筒井裕之1, 永井良三2 1九州大学, 2自治医科大学, 3東京大学, 4東北大学, 5国立循環器病研究センター, 6熊本大学, 7 プレシジョン, for the CLIDAS Research Group

    日本動脈硬化学会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都国際会議場   Country：Japan  

  • 酸化ステロールの炎症と老化における役割 Invited

    26. 的場哲哉, 古賀 純一郎, 香月 俊輔, 内川 智貴, 馬場 功士, 江頭 健輔, 筒井 裕之

    第52回日本動脈硬化学会総会  2020.7 

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    Event date： 2020.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：WEB   Country：Japan  

  • Targeting Cyclophilin D and Inflammation with Nano-medicines in Myocardial Ischemia-Reperfusion Injury Invited

    Tetsuya Matoba, Gentaro Ikeda, Jun-ichiro Koga, Hiroyuki Tsutsui, Kensuke Egashira

    3rd Annual 2019 International Hawaii Cardiovascular Symposium  2019.2 

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    Event date： 2019.2

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United States  

  • 心臓カテーテルを中心とした多モダリティ循環器診療情報を収集するJ-IMPACTシステム Invited International conference

    的場哲哉1, 興梠貴英2, 藤田英雄2, 中山雅晴3, 清末有宏4, 橋本英樹4, 大江和彦4, 宮本恵宏5, 西村邦宏5, 小川久雄5, 安徳恭彰1, 中島直樹1, 筒井裕之1, 永井良三2 1九州大学, 2自治医科大学, 3東北大学, 4東京大学, 5国立循環器病研究センター;日本循環器学会IT/Database委員会

    第38回医療情報学連合大会（第19回日本医療情報学会学術大会）  2019.6 

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    Event date： 2018.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

    循環器疾患は心筋梗塞、脳卒中を代表とした血管病により日本人の生活の質を損ねる重大な疾患領域である。特徴的に発展した心臓カテーテル検査・心臓カテーテルインターベンション治療の診療情報、また、大規模臨床試験のエビデンスに基づく薬物療法などの診療情報などは、構造化データとして個別患者のリスク予測や治療プロセスの再評価に利用されるべきであるが、多モダリティの診療情報を電子的に収集するシステムは存在しなかった。我々は日本循環器学会およびImPACT事業の支援を受け、電子カルテにおける患者基本情報、処方、検体検査データをSS-MIX2標準ストレージから、また、生理検査や心臓カテーテル検査・心臓カテーテルインターベンション治療レポートの情報をSS-MIX2拡張ストレージから収集するJapan Ischemic Heart Disease Multimodal Prospective Data Acquisition for Precision Treatment (J-IMPACT)システムを開発してきた。本発表ではJ-IMPACTシステムの現状と課題を議論したい。

  • The Impact of Institutional Characteristics on the Prognosis of Acute Myocardial Infarction with Cardiogenic Shock: Analysis from the JROAD/JROAD-DPC International conference

    Tetsuya Matoba, Kazuo Sakamoto, Masahiro Mohri, Yasuyuki Tsujita, Masao Yamasaki, Yasushi Ueki, Nobuhiro Tanaka, Yohei Hokama, Motoki Fukutomi, Katsutaka Hashiba, Rei Fukuhara, Yasushi Ueki, Satoru Suwa, Hirohide Matsuura, Eizo Tachibana, Takahiro Nakashima, Hayato Hosoda, Yoshio Tahara, Michikazu Nakai, Kunihiro Nishimura, Naohiro Yonemoto, Ken Nagao

    2018.6 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Nanoparticle-Mediated Monocyte-Selective Drug Delivery System for Treatment of Atherosclerotic Cardiovascular Disease Invited

    Tetsuya Matoba, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    Cardiovascular System Dynamics Society 2010  2010.9 

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    Event date： 2010.9

    Language：Others   Presentation type：Oral presentation (general)  

    Country：Japan  

  • プラーク破綻における酸化ステロールの役割 Invited International conference

    的場哲哉、香月俊輔、古賀純一郎、江頭健輔、筒井裕之

    第55回日本動脈硬化学会総会  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：宇都宮   Country：Japan  

  • 動脈硬化性疾患予防ガイドライン 2022 年版の改訂のポイント Invited

    的場哲哉

    日本動脈硬化学会・家族性高コレステロール血症および動脈硬化性疾患予防新ガイドラインの啓発講演会  2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Impact of Heart Failure Severity and Major Bleeding Events after Percutaneous Coronary Intervention on Subsequent All-cause Death(タイトル和訳中)

    池邉 壮, 石井 正将, 大塚 康弘, 中村 太志, 辻田 賢一, 藤田 英雄, 的場 哲哉, 興梠 貴英, 甲谷 友幸, 苅尾 七臣, 清末 有宏, 水野 由子, 中山 雅晴, 宮本 恵宏, 佐藤 寿彦, 永井 良三

    日本循環器学会学術集会抄録集  2023.3 

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    Event date： 2023.3

    Language：English  

    Country：Other  

  • Changes in Systolic Blood Pressure during Hospitalization and Bleeding Events after Percutaneous Coronary Intervention: Insight from the CLIDAS Database(タイトル和訳中)

    石井 正将, 大塚 康弘, 池邉 壮, 中村 太志, 辻田 賢一, 藤田 英雄, 的場 哲哉, 興梠 貴英, 甲谷 友幸, 苅尾 七臣, 清末 有宏, 水野 由子, 中山 雅晴, 宮本 恵宏, 佐藤 寿彦, 永井 良三

    日本循環器学会学術集会抄録集  2023.3 

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    Event date： 2023.3

    Language：English  

    Country：Other  

  • 急性心筋梗塞治療に求められるイノベーション Invited

    2021.12 

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    Event date： 2021.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン   Country：Japan  

  • 循環器内科領域における臨床業務負担軽減を目指したICTの活用 Invited

    的場 哲哉1, 坂本 和生1, 古賀 純一郎1, 山下 貴規2, 佐藤 寿彦3, 井上 創造5, 副島 秀久4, 筒井 裕之1, 中島 直樹2 1九州大学病院循環器内科, 2九州大学病院メディカルインフォメーションセンター, 3株式会社プレシジョン, 4済生会熊本病院, 5九州工業大学大学院生命体工学研究科

    第41回医療情報学連合学会・第22回日本医療情報学会学術大会  2021.11 

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    Event date： 2021.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 冠動脈インターベンション術後の脂質管理と残余リスク Invited

    的場哲哉, 仲野泰啓, 香月俊輔, 古賀純一郎, 江頭健輔, 筒井裕之

    日本動脈硬化学会学術集会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • コレステロール吸収・合成マーカーと心血管疾患の関連：CACHE研究CVD解析 Invited

    的場哲哉, 秋山雄介, 吉田博, 小谷和彦, 庄司哲雄, The CACHE Investigators

    日本動脈硬化学会学術集会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

    【背景】心血管疾患(CVD)とコレステロール(Ch)合成および吸収との関連は十分に解明されていない。
    【方法】全国17の研究グループからなるCACHE Consortiumを結成し、REDCapを用い健常人を含む2944例のCACHE集団から、合成マーカーとして血清Lathosterol (Latho)、吸収マーカーとして血清Campesterol (Campe)濃度をGas chromatographyで測定した2895例を解析対象集団とした。ロジスティック回帰を使用して、背景因子調整後にLatho、Campe、およびその比がCVDの有無, および, 心血管疾患に内包される冠動脈疾患, 脳血管障害, 末梢動脈疾患の有無に関連するかを推計した。
    【結果】平均年齢57.0歳、男性57.0&#37;、スタチン内服率は13.7&#37;、エゼチミブ内服率は2.2&#37;であった。CampeおよびCampe/Latho比の高値は心血管疾患、冠動脈疾患、および末梢動脈疾患の存在と有意な関連を示した。一方、脳血管障害とは有意な関連を示さなかった。
    【結論】コレステロール腸管吸収および吸収／合成比はCVDリスク評価に有用である可能性がある。

  • 冠動脈ステント留置後AF患者の抗血栓療法: AFIRE試験サブ解析の結果を臨床に活かす Invited

    的場哲哉

    第57回日本心血管インターベンション治療学会・関東甲信越地方会  2021.5 

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    Event date： 2021.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：WEB   Country：Japan  

  • 心房細動を合併した冠動脈疾患に対するインターベンション治療戦略 Invited

    的場哲哉

    第259回日本循環器学会関東甲信越地方会  2021.2 

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    Event date： 2021.2

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：WEB   Country：Japan  

  • 「減らすエビデンス」と最新ガイドラインに基づく冠動脈疾患合併AF患者の最適抗血栓療法 Invited

    的場哲哉

    第13回日本不整脈心電学会・植込みデバイス関連冬季大会  2021.2 

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    Event date： 2021.2

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：WEB   Country：Japan  

  • ePathデータに基づくカテーテルアブレーション治療経過の可視化と臨床研究での活用 Invited

    的場哲哉, 古賀純一郎, 坂本和生, 山下貴範, 劔卓夫, 中熊英貴, 神馬崇宏, 若田好史, 副島秀久, 中島直樹

    第40回医療情報学連合大会・第21回日本医療情報学会学術大会  2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：静岡県・アクトシティ浜松   Country：Japan  

  • 心房細動合併・安定冠動脈疾患の抗血栓療法：AFIRE試験から考察する

    25. 的場哲哉, 安田聡, 海北幸一, 赤尾昌治, 阿古潤哉, 中村正人, 宮内克己, 萩原誠久, 木村一雄, 平山篤志, 松井邦彦, 筒井裕之, 小川久雄

    第33回日本冠疾患学会学術集会  2019.12 

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    Event date： 2019.12

    Language：Japanese  

    Venue：岡山   Country：Japan  

  • 臨床効果データベース事業・ImPACT 研究におけるデータ収集の現状 Invited International conference

    的場哲哉, 興梠貴英, 藤田英雄, 中山雅晴, 清末有宏, 橋本英樹, 大江和彦, 宮本恵宏, 西村邦宏, 小川久雄, 安徳恭彰, 中島直樹, 筒井裕之, 永井良三

    日本循環器学会学術集会  2018.3 

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    Event date： 2018.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大阪   Country：Japan  

  • 新世代DES留置冠動脈のHealing ーイメージングと血管機能から考えるー Invited

    的場哲哉

    第26回 CVIT九州・沖縄地方会  2018.1 

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    Event date： 2018.1

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • Responses to Acetylcholine in Stented Target Vessel in Comparison to Non-Target Vessel in Patients after Percutaneous Coronary Intervention International conference

    Yusuke Akiyama, Tetsuya Matoba, Yasushi Mukai, Daisuke Furukawa, Keiji Oi, Shunji Hayashidani, Toyokazu Uwatoku, Hiroyuki Tsutsui

    American Heart Association Scientific Session  2017.11 

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    Event date： 2017.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • ポリファーマシー時代のDOACの役割 Invited

    的場哲哉

    第58回日本脈管学会総会  2017.10 

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    Event date： 2017.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：名古屋   Country：Japan  

  • Novel Nanoparticle-mediated Medicine for Myocardial Ischemia-Reperfusion Injury Simultaneously Targeting Mitochondrial Injury and Myocardial Inflammation. International conference

    European Society of Cardiology (ESC) Congress 2016  2017.8 

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    Event date： 2017.8

    Language：English   Presentation type：Oral presentation (general)  

    Country：Italy  

  • Primary PCI for STEMI with cardiogenic shock in Japan Invited International conference

    Tetsuya Matoba

    2017.7 

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    Event date： 2017.7

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • ポリファーマシー時代のDOACの役割−リアルワールドデータを読み解く Invited

    的場哲哉

    第122回 日本循環器学会九州地方会  2017.6 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 冠動脈疾患予防のために非スタチン脂質低下薬をどう使うか Invited

    的場哲哉

    国際心血管薬物療法学会日本部会（J-ISCP）学術集会  2017.6 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • Prognostic Impact of Post-procedural TIMI Flow Grade in STEMI Patients with Cardiogenic Shock Undergoing Primary Percutaneous Coronary Intervention - Analysis from JCS Shock Registry. International conference

    2017.6 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Treatment of Myocardial Ischemia-Reperfusion Injury by Nanoparticle-Mediated Targeting Mitochondria and Inflammation. Invited International conference

    New Frontiers in Cell death Signaling and Heart Failure  2017.2 

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    Event date： 2017.2

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Novel Nanoparticle-Mediated Medicine for Myocardial Ischemia-Reperfusion Injury. Invited International conference

    2016.12 

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    Event date： 2016.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • コレステロール吸収阻害薬エゼチミブの血管保護メカニズム． Invited

    的場 哲哉

    日本血管生物学会 秋季特別シンポジウム  2016.9 

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    Event date： 2016.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • エゼチミブはPCI標的血管の予後を改善するか？ Invited

    的場 哲哉

    第23回日本心血管インターベンション治療学会九州・沖縄地方会  2016.8 

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    Event date： 2016.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 1. Imaging and Targeting Inflammation in Acute Myocardial Infarction. Invited International conference

    The 10th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Diseases (APSAVD)  2016.7 

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    Event date： 2016.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • エゼチミブはPCI標的血管の予後を改善するか？ Invited International conference

    的場 哲哉

    第25回日本心血管インターベンション治療学会学術集会ランチョンセミナーLS-5  2016.7 

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    Event date： 2016.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • Effect of Cholesterol Absorption Inhibitor, Ezetimibe, on Coronary Endothelial Dysfunction in Target Vessels after Stenting, CuVIC Trial

    2015.4 

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    Event date： 2016.4

    Language：Japanese  

    Country：Japan  

  • Nanoparticle-mediated Drug Delivery System for Atherosclerotic Cardiovascular Disease Invited

    2015.7 

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    Event date： 2015.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • CuVIC Trialから考察する冠動脈疾患二次予防におけるエゼチミブの役割 Invited

    的場 哲哉

    第47回日本動脈硬化学会総会・学術集会  2015.6 

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    Event date： 2015.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：仙台国際センター   Country：Japan  

  • 動脈硬化性疾患治療における脂質低下療法とエゼチミブの役割 Invited

    的場 哲哉, 江頭 健輔

    第15回抗加齢医学会総会  2015.5 

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    Event date： 2015.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡国際会議場   Country：Japan  

  • Decision Making for Anticoagulation in AF: Combining Global and Asian Studies to Clinical Practices Invited International conference

    2015 Taiwan Society of Cardiology Annual Meeting  2015.5 

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    Event date： 2015.5

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Taiwan, Province of China  

  • 急性心筋梗塞における炎症病態と治療戦略 Invited

    的場 哲哉, 江頭 健輔

    脳心血管抗加齢研究会  2014.12 

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    Event date： 2014.12

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大阪   Country：Japan  

  • 糖尿病患者に対するOptimal PCIVascular Biologyからのアプローチ Invited

    的場 哲哉

    2014.11 

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    Event date： 2014.11

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：福岡   Country：Japan  

  • Murine Model of Atherosclerotic Plaque Destabilization and Rupture in ApoE-Deficient Mice Invited

    Tetsuya Matoba

    2013.7 

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    Event date： 2013.7

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Critical Role of Inflammatory Monocytes in Atherosclerotic Plaque Destabilization and Rupture Invited International conference

    Tetsuya Matoba

    The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2013)  2013.7 

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    Event date： 2013.7

    Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Country：Japan  

    Other Link： http://embc2013.embs.org/ls.html

  • Pathophysiology of Atherosclerotic Plaque Destabilization and Rupture Invited International conference

    Tetsuya Matoba

    The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2013)  2013.7 

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    Event date： 2013.7

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

    Other Link： http://embc2013.embs.org/ss.html

  • Critical Role of Inflammatory Monocytes in Atherosclerotic Plaque Destabilization and Rupture in ApoE-Deficient Mice Invited International conference

    Tetsuya Matoba

    International Society of Heart Research Japanese Section  2013.6 

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    Event date： 2013.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United States  

  • 活性化単球/マクロファージの動脈硬化性プラークの不安定化・破綻における役割 Invited International conference

    的場 哲哉, 香月 俊輔, 中野 覚, 砂川 賢二, 江頭 健輔

    日本動脈硬化学会総会・学術集会  2012.7 

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    Event date： 2012.7

    Language：Others   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • High Incidence of Coronary Vasospasm After Sirolimus-Eluting Stent Implantation - Role of Rho-associated Kinase Activation

    2010.3 

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    Event date： 2010.3

    Language：Others   Presentation type：Oral presentation (general)  

    Country：Japan  

  • クイズで学ぶ循環器集中治療2023(心原性ショック)　心原性ショックの急性期診療　救急診療から集中治療までを極める

    田中 哲人, 松尾 邦浩, 的場 哲哉

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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    Language：Japanese  

  • クイズで学ぶ循環器集中治療2023(心原性ショック)　心原性ショック症例の集中治療室における管理

    中島 啓裕, 近藤 徹, 新井 真理奈, 的場 哲哉

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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    Language：Japanese  

  • スタチンとエゼチミブによる脂質低下療法における血清オキシステロールと冠動脈プラーク退縮の関連性　CuVIC試験サブグループ解析

    仲野 泰啓, 的場 哲哉, 山本 光孝, 香月 俊輔, 高瀬 進, 向井 靖, 弘永 潔, 末松 延裕, 肥後 太基, 門上 俊明, 筒井 裕之

    日本動脈硬化学会総会プログラム・抄録集  2022.7  (一社)日本動脈硬化学会

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  • コレステロール吸収を軸とした病態理解と治療の展開

    的場 哲哉, 香月 俊輔, 江頭 健輔, 筒井 裕之

    日本動脈硬化学会総会プログラム・抄録集  2023.6  (一社)日本動脈硬化学会

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  • コイル+ステントを用いて閉鎖した巨大瘤を伴う冠動脈肺動脈瘻の一例

    長友 雄作, 仲野 泰啓, 香月 俊輔, 的場 哲哉, 江口 祥美, 豊村 大亮, 平田 悠一郎, 永田 弾, 山村 健一郎, 筒井 裕之, 大賀 正一

    日本成人先天性心疾患学会雑誌  2022.1  (一社)日本成人先天性心疾患学会

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  • クリニカルパスの標準化とその効果

    若田 好史, 山下 貴範, 中熊 英貴, 的場 哲哉, 船越 公太, 戸高 浩司, 岡田 美保子, 中島 直樹, 副島 秀久

    日本医療情報学会春季学術大会プログラム・抄録集  2023.6  (一社)日本医療情報学会

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  • クイズで学ぶ循環器集中治療2023(心原性ショック)　症例提示　急性冠症候群によるショック症例に関する治療の優先順位

    片迫 彩, 坂本 和生, 羽柴 克孝, 的場 哲哉

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • クイズで学ぶ循環器集中治療2023(心原性ショック)　症例提示　心原性ショックを疑う症例の判断

    桐ヶ谷 仁, 岡崎 雄介, 山本 剛, 的場 哲哉

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • クイズで学ぶ循環器集中治療2023(心原性ショック)　症例提示　ショック症例に対する心血管作動薬の選択

    山本 正啓, 細谷 弓子, 花田 裕之, 辻田 賢一, 田原 良雄, 的場 哲哉

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • クイズで学ぶ循環器集中治療2023(心原性ショック)　症例提示　ショック症例に対する初期診療医の役割り

    中山 尚貴, 石津 智子, 的場 哲哉

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • インパクトファクターって重要?

    的場 哲哉

    日本臨床検査医学会誌  2023.10  (一社)日本臨床検査医学会

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  • Recent Evidence of the Social System for ST Elevated Myocardial Infarction　Management of AMI in Japan: Findings from the Nationwide JROAD Studies(タイトル和訳中)

    Matoba Tetsuya

    日本循環器学会学術集会抄録集  2024.3  (一社)日本循環器学会

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  • Delta-like ligand 1はApoe-/-マウスにおいてマクロファージの活性化ならびに動脈硬化を促進する

    古賀 純一郎, 香月 俊輔, 的場 哲哉, 筒井 裕之

    日本動脈硬化学会総会プログラム・抄録集  2022.7  (一社)日本動脈硬化学会

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  • COVID-19パンデミックが日本の急性心筋梗塞救急医療に与えた影響(The Impact of COVID-19 Pandemic on the Emergency Cardiovascular Cares for Acute Myocardial Infarction in Japan)

    Kimura Mitsukuni, Matoba Tetsuya, Sakamoto Kazuo, Nishihara Masaaki, Nagata Takuya, Tahara Yoshio, Nagao Ken, Kobayashi Yoshio, Ikeda Takanori, Tsutsui Hiroyuki

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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  • Challenging cases in interventional cardiology　小児科と内科で共闘して塞栓治療を行った冠動脈瘻症例

    長友 雄作, 仲野 泰啓, 香月 俊輔, 小林 優, 豊村 大亮, 平田 悠一郎, 永田 弾, 的場 哲哉, 大賀 正一

    日本小児循環器学会総会・学術集会抄録集  2023.7  (NPO)日本小児循環器学会

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  • Burden of Adverse Clinical Outcomes Attributable to Bleeding Complication in Patients with Percutaneous Coronary Intervention(タイトル和訳中)

    石井 正将, 大塚 康弘, 池邉 壮, 中村 太志, 辻田 賢一, 藤田 英雄, 的場 哲哉, 興梠 貴英, 大場 祐輔, 甲谷 友幸, 苅尾 七臣, 清末 有宏, 水野 由子, 中山 雅晴, 宮本 恵宏, 佐藤 寿彦, 永井 良三

    日本循環器学会学術集会抄録集  2024.3  (一社)日本循環器学会

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  • Beyond LDL:動脈硬化性疾患の残余リスクと闘う!　内皮機能不全と心筋虚血再灌流障害におけるオキシステロールの役割(Role of Oxysterols in Endothelial Dysfunction and Myocardial Ischemia-Reperfusion Injury)

    香月 俊輔, Matoba Tetsuya, Uchikawa Tomoki, Takase Susumu, Koga Jun-ichiro, Tsutsui Hiroyuki

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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  • "Cardiac Caput Medusae"に対する低侵襲カテーテルインターベンション治療(A Minimally Invasive Catheter Intervention for 'Cardiac Caput Medusae')

    Nakano Yasuhiro, Matoba Tetsuya, Nagatomo Yusaku, Katsuki Shunsuke, Samamoto Ichiro, Hayashidani Shunji, Kimura Satoshi, Shiose Akira, Tsutsui Hiroyuki

    日本心血管インターベンション治療学会抄録集  2022.7  (一社)日本心血管インターベンション治療学会

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  • Japan Atherosclerosis Society(JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022(タイトル和訳中)

    Okamura Tomonori, Tsukamoto Kazuhisa, Arai Hidenori, Fujioka Yoshio, Ishigaki Yasushi, Koba Shinji, Ohmura Hirotoshi, Shoji Tetsuo, Yokote Koutaro, Yoshida Hiroshi, Yoshida Masayuki, Deguchi Juno, Dobashi Kazushige, Fujiyoshi Akira, Hamaguchi Hirotoshi, Hara Masumi, Harada-Shiba Mariko, Hirata Takumi, Iida Mami, Ikeda Yoshiyuki, Ishibashi Shun, Kanda Hideyuki, Kihara Shinji, Kitagawa Kazuo, Kodama Satoru, Koseki Masahiro, Maezawa Yoshiro, Masuda Daisaku, Miida Takashi, Miyamoto Yoshihiro, Nishimura Rimei, Node Koichi, Noguchi Midori, Ohishi Mitsuru, Saito Isao, Sawada Shojiro, Sone Hirohito, Takemoto Minoru, Wakatsuki Akihiko, Yanai Hidekatsu, Fujihara Kazuya, Hasegawa Koji, Hiraishi Chika, Honda Takanori, Horiuchi Hisanori, Katsuyama Hisayuki, Kuwabara Akiko, Matsui Sadako, Matsuki Kota, Mianamino Tetsuo, Morishita Eriko, Nakao Yoko M., Natsuaki Masahiro, Nishikido Toshiyuki, Ohtake Akira, Okazaki Hiroaki, Sugiyama Daisuke, Tada Hayato, Taketani Yutaka, Tamori Yoshikazu, Tanaka Atsushi, Yamamoto Yukiyo, Yamashita Shizuya, Yamato Hiroshi, Yoshizumi Toru, Ando Koichi, Chiba Hiraku, Doi Takahito, Emori Hiroki, Fukushima Yoshifumi, Hayashi Aiko, Higashiyama Aya, Hirata Aya, Hirayama Satoshi, Inagaki Kyoko, Ishikawa Takahiro, Iso-o Naoyuki, Kanno Kotaro, Kataoka Yu, Kinoshita Daisuke, Kinuta Minako, Kohmo Kyoko, Koshizaka Masaya, Kubota Yoshimi, Makino Hisashi, Maruyama Koutatsu, Matsubara Masaki, Nakagawa-Tsutsui Wao, Nakai Yasuo, Nakamoto Mariko, Narumi-Hyakutake Aiko, Nishikawa Tetsuo, Nomura Akihiro, Oda Tomoyasu, Ogura Masatsune, Oohira Hideo, Ohminami Hirokazu, Okada Takeshi, Okada Hirofumi, Okajima Fumitaka, Okamoto Rie, Okazaki Sachiko, Omote Shizuko, Saiki Atsuhito, Sakamoto Kaori, Sata Mizuki, Sato Kayoko, Shiratori Yoshitaka, Shoji Mayumi, Suganuma Yuka, Suzuki Daisuke, Suzuki Harumitsu, Suzuki Nobuaki, Takahashi Hiroshi, Takahashi Yutaro, Takanashi Mikio, Takase Satoru, Takebe Noriko, Tamura Yukinori, Tanaka Kaki, Tanaka Katsunao, Tanaka Sarasa, Tanaka Yoshihiro, Terada Kousei, Teramoto Naoya, Tsukagoshi-Yamaguchi Ayano, Wakasa Hana, Yako Rie, Yamada Eri, Yamamoto Masashi, Yashiro Satoshi, Yokota Yuya, Yoshimura Yukihiro, Yan Zhang, Akishita Masahiro, Ako Junya, Bujo Hideaki, Emoto Masanori, Goto Shinya, Hanada Hiroyuki, Hosomi Naohisa, Hozawa Atsushi, Ikewaki Katsunori, Ishida Tatsurou, Kajinami Kouji, Kameyama Noriko, Kikuchi Toru, Kozaki Koichi, Kuwabara Kazuyo, Masuzaki Hiroaki, Matoba Tetsuya, Matoba Yuka, Miyata Masaaki, Ninomiya Toshiharu, Ogura Masatsune, Ohtsuki Toshiho, Ohya Yusuke, Okuda Nagako, Saitoh Shigeyuki, Shimano Hitoshi, Tomiyama Hirofumi, Toyoda Kazunori, Tsushita Kazuyo, Ueda Yukihiko, Umemoto Seiji, Yahagi Naoya, Yamagishi Kazumasa, Yamashita Tomoya, Daida Hiroyuki, Kinoshita Makoto, Yokode Masayuki, Japan Atherosclerosis Society

    Journal of Atherosclerosis and Thrombosis   31 ( 6 )   641 - 853   2024.6   （ ISSN:1340-3478 ）

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    Language：English   Publisher：(一社)日本動脈硬化学会  

  • 【血管・リンパ管研究の最前線と治療への展開】血管疾患と血管を標的とした治療法　心血管病の炎症における酸化ステロールの分子生物学的役割の解明

    香月 俊輔, 的場 哲哉

    医学のあゆみ   289 ( 13 )   1134 - 1140   2024.6   （ ISSN:0039-2359 ）

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    Language：Japanese   Publisher：医歯薬出版(株)  

    ＜文献概要＞冠動脈疾患における脂質異常症のリスクが明らかになり,3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)還元酵素阻害薬(スタチン)をはじめとする脂質低下薬が動脈硬化性心血管病に対する標準治療となってきた.現在の脂質低下療法の管理においてはLDLコレステロール(LDL-C)が指標とされているが,筆者らの研究グループは,酸化脂質のひとつである酸化ステロールの心血管病における役割と,コレステロール吸収阻害薬エゼチミブの酸化ステロール吸収阻害効果に着目し,冠動脈内皮機能をアウトカムとした臨床試験CuVIC Trialでその作用を検討した.また,酸化ステロールの腸管吸収と心血管病の関連について,単球・マクロファージによる炎症の観点から基礎的研究の結果を踏まえて考察した.本稿では,心血管病の炎症における酸化ステロールの役割について,最新の知見を含めて概説する.

  • 【冠攣縮性狭心症と冠微小循環障害:新たな知見】冠微小血管攣縮の病態・疫学

    仲野 泰啓, 的場 哲哉

    循環器内科   94 ( 4 )   380 - 385   2023.10   （ ISSN:1884-2909 ）

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  • 【脂質異常症と循環器疾患update】LDL-C管理の現状と未来

    香月 俊輔, 的場 哲哉

    循環器内科   94 ( 1 )   34 - 39   2023.7   （ ISSN:1884-2909 ）

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  • 【MINOCAの病態・診断・治療】INOCA/MINOCAと心不全

    的場 哲哉, 仲野 泰啓, 筒井 裕之

    医学のあゆみ   285 ( 11 )   1010 - 1013   2023.6   （ ISSN:0039-2359 ）

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    Language：Japanese   Publisher：医歯薬出版(株)  

    心外膜冠動脈の器質的狭窄病変に基づく冠動脈疾患は従来からよく認職されてきたが,冠動脈閉塞を伴わない心筋虚血(INOCA)および冠動脈閉塞を伴わない心筋梗塞(MINOCA)の存在とその病態に注目が集まっている.INOCAまたはMINOCAを基礎とした心筋虚血や心筋梗塞による左室機能障害は,心不全の原因となる.一方,心不全の原因疾患となる心筋症や左室肥大は,冠微小循環障害(CMD)を惹起することによってINOCA/MINOCAの原因となる.本稿ではINOCA/MINOCAと心不全の関係に焦点を当て,心不全診療におけるINOCA/MINOCAおよびCMDの重要性を議論する.(著者抄録)

  • 【心筋梗塞の診療と予防のエッセンス】心筋梗塞診療の現状と展望

    仲野 泰啓, 的場 哲哉, 筒井 裕之

    臨牀と研究   100 ( 5 )   525 - 531   2023.5   （ ISSN:0021-4965 ）

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    Language：Japanese   Publisher：大道学館出版部  

  • 【ST上昇型心筋梗塞update】MINOCA up-to-date

    仲野 泰啓, 的場 哲哉, 筒井 裕之

    循環器内科   93 ( 3 )   293 - 299   2023.3   （ ISSN:1884-2909 ）

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  • 【最強の心原性ショックチームを作ろう】識る　心原性ショックのレジストリ研究

    坂本 和生, 的場 哲哉, 筒井 裕之

    Heart View   27 ( 1 )   44 - 48   2023.1   （ ISSN:1342-6591 ）

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    Language：Japanese   Publisher：(株)メジカルビュー社  

    ＜文献概要＞Point　1 心原性ショックの原疾患の約半数は急性冠症候群である。2 心原性ショックに対する体外式膜型人工肺(VA-ECMO)使用期間は,予後と関連する可能性がある。3 レジストリ研究は,心原性ショックなどの循環器救急疾患において有用である。

  • Percutaneous coil embolization and stent implantation for multiple coronary-to-pulmonary artery fistulas with giant coronary aneurysms: a case report.

    Yasuhiro Nakano, Tetsuya Matoba, Yusaku Nagatomo, Hiroyuki Tsutsui

    European heart journal. Case reports   2022.3

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    DOI： 10.1093/ehjcr/ytac104

  • 大規模精密臨床情報基盤CLIDASと医学的有用性

    的場哲哉、仲野泰啓、興梠貴英、今井靖、苅尾七臣、藤田英雄、明石直之、清末有宏、水野由子、中山雅晴、後岡広太郎、宮本恵宏、辻田賢一、永井良三、筒井裕之

    循環器内科（科学評論社）   2022.1

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  • Impact of Prehospital 12-Lead Electrocardiography and Destination Hospital Notification on Mortality in Patients With Chest Pain　― A Systematic Review ― Reviewed

    2022.1

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    DOI： 10.1253/circrep.CR-22-0003

  • Performance of the 0-Hour/1-Hour Algorithm for Diagnosing Myocardial Infarction in Patients With Chest Pain in the Emergency Department　― A Systematic Review and Meta-Analysis ― Reviewed

    2022.1

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    DOI： 10.1253/circrep.CR-22-0001

  • Effects of Door-In to Door-Out Time on Mortality Among ST-Segment Elevation Myocardial Infarction Patients Transferred for Primary Percutaneous Coronary Intervention ― Systematic Review and Meta-Analysis ― Reviewed

    2021.12

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    DOI： 10.1253/circrep.CR-21-0160

  • 心原性ショックのレジストリ研究 Reviewed

    的場哲哉、筒井裕之

    循環器内科（科学評論社）   2021.11

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  • 酸化ステロールと動脈硬化性疾患 Reviewed

    的場哲哉、高瀬進、本田勝也、江頭健輔、筒井裕之

    循環器内科（科学評論社）   2021.10

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  • 冠動脈疾患

    的場哲哉, 筒井裕之

    2020.6

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    Language：Japanese  

  • 酸化コレステロールと心臓病

    的場哲哉

    2020.4

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    Language：Japanese  

  • 多モダリティ循環器診療情報を収集するCLIDASデータベース

    的場 哲哉, 興梠 貴英, 藤田 英雄, 苅尾 七臣, 中山 雅晴, 清末 有宏, 辻田 賢一, 宮本 恵宏, 中島 直樹, 筒井 裕之, 永井 良三

    医療情報学連合大会論文集   2019.11

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    Language：Japanese  

  • 多モダリティ循環器診療情報を収集するCLIDASデータベース

    的場 哲哉, 興梠 貴英, 藤田 英雄, 苅尾 七臣, 中山 雅晴, 清末 有宏, 辻田 賢一, 宮本 恵宏, 中島 直樹, 筒井 裕之, 永井 良三

    医療情報学連合大会論文集   2019.11

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  • 『急性冠症候群ガイドライン (2018年改訂版)』について - 外部評価委員の立場から -

    仲野泰啓, 的場哲哉, 筒井裕之

    2019.6

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  • 心筋梗塞と心筋傷害の新たな定義.

    仲野泰啓, 的場哲哉, 筒井裕之

    2019.6

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  • Unexpected, but reasonable association between anderson-fabry disease and coronary vasospasm

    Tetsuya Matoba, Yasuhiro Nakano, Hiroyuki Tsutsui

    Circulation Journal   2019.2

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    Unexpected, but reasonable association between anderson-fabry disease and coronary vasospasm

    DOI： 10.1253/circj.CJ-18-1355

  • 動脈硬化と炎症

    的場哲哉, 江頭健輔, 筒井裕之

    2018.6

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  • 脂質異常症治療薬の現況と将来展望：エゼチミブ

    的場哲哉, 高瀬進, 筒井裕之

    2018.5

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  • カルシウム拮抗薬

    的場哲哉, 秋山雄介, 筒井裕之

    2018.4

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  • 心原性ショックを伴う急性心筋梗塞の予後に施設特徴が及ぼす影響 JROAD/JROAD-DPCの分析(The impact of institutional characteristics on the prognosis of acute myocardial infarction with cardiogenic shock: Analysis from the JROAD/JROAD-DPC)

    的場 哲哉, 坂本 和生, 立花 栄三, 米本 直裕, 長尾 建

    2018.4

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  • Anti-inflammatory Nanomedicine for Cardiovascular Disease Reviewed

    Shunsuke Katsuki, Tetsuya Matoba, Jun Ichiro Koga, Kaku Nakano, Kensuke Egashira

    Frontiers in Cardiovascular Medicine   2017.12

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    DOI： 10.3389/fcvm.2017.00087

  • 心原性ショック患者への対応

    市村研三, 的場哲哉, 前原喜彦, 筒井裕之

    2017.11

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  • Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease.

    Matoba T, Koga J-I, Nakano K, Egashira K, Tsutsui H

    J Cardiol   2017.9

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    DOI： 10.1016/j.jjcc.2017.03.005

    Other Link： http://linkinghub.elsevier.com/retrieve/pii/S0914508717300928

  • Response by Takase and Matoba to Letter Regarding Article, "Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial".

    Tetsuya Matoba, Susumu Takase

    2017.5

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  • Statin and Ezetimibe Differently Affect Spontaneous Atherothrombotic Occlusion in a Rabbit Model of Plaque Erosion

    Tetsuya Matoba, Katsuya Honda, Jun-ichiro Koga, Kaku Nakano, Hiroyuki Tsutsui, Kensuke Egashira

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   2017.5

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  • Response by Takase and Matoba to Letter Regarding Article, "Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial"

    Susumu Takase, Tetsuya Matoba

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   2017.5

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    DOI： 10.1161/ATVBAHA.117.309301

  • Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease

    Tetsuya Matoba, Jun-ichiro Koga, Kaku Nakano, Egashira kensuke, Hiroyuki Tsutsui

    Journal of Cardiology   2017.4

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    Other Link： http://linkinghub.elsevier.com/retrieve/pii/S0914508717300928

  • CLINICAL CHARACTERISTICS AND IN-HOSPITAL MORTALITY OF VERY ELDERLY PATIENTS WITH CARDIOVASCULAR SHOCK IN JAPAN: THE RESULTS FROM JAPANESE CIRCULATION SOCIETY SHOCK REGISTRY Reviewed

    Ken Onitsuka, Masahiro Mohri, Yasushi Ueki, Satoru Suwa, Hiroshi Takahashi, Yohei Hokama, Nobuhiro Tanaka, Toshiaki Kadokami, Tetsuya Matoba, Rei Fukuhara, Tsukasa Yagi, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   2017.3

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  • Anti-inflammatory Nanomedicine for Cardiovascular Disease Reviewed

    Shunsuke Katsuki, Tetsuya Matoba, Jun-Ichiro Koga, Kaku Nakano, Kensuke Egashira

    Frontiers in cardiovascular medicine   2017

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    DOI： 10.3389/fcvm.2017.00087

  • Optical Frequency Domain Imaging of Covered Stent-Graft for Pulmonary Artery Pseudoaneurysm After Balloon Pulmonary Angioplasty

    2016.11

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    DOI： 10.1016/j.jcin.2016.08.022

  • 急性心筋梗塞に対するナノ薬物送達システムの開発 (特集 わが国の心血管病に対する先進医療)

    的場 哲哉, 古賀 純一郎, 中野 覚, 江頭 健輔

    循環器内科 = Cardioangiology   2016.10

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  • Nanoparticle-Mediated Targeting of Pitavastatin into Small Pulmonary Arteries by Intravenous Administration Attenuates the Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats

    Kenzo Ichimura, Tetsuya Matoba, Kaku Nakano, Masaki Tokutome, Jyunichiro Koga, Kensuke Egashira

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Nanoparticles-Mediated Targeting of Pioglitazone Reduces Myocardial Ischemia-Reperfusion Injury and Cardiac Remodeling by Antagonizing Monocyte/Macrophage-mediated Inflammation in Preclinical Animal Models

    Masaki Tokutome, Tetsuya Matoba, Yasuhiro Nakano, Kaku Nakano, Kensuke Egashira

    JOURNAL OF CARDIAC FAILURE   2016.9

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  • Nanoparticle-mediated targeting of pitavastatin into small pulmonary arteries by intravenous administration attenuates the progression of monocrotaline-induced pulmonary arterial hypertension in rats

    K. Ichimura, T. Matoba, K. Nakano, K. Egashira

    EUROPEAN HEART JOURNAL   2016.8

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  • Novel nanoparticle-mediated medicine for myocardial ischemia-reperfusion injury simultaneously targeting mitochondrial injury and myocardial inflammation

    G. Ikeda, T. Matoba, A. Ishikita, K. Nakano, K. Egashira

    EUROPEAN HEART JOURNAL   2016.8

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  • 心原性ショックを受けた急性冠動脈症候群患者における血行再建の予後に対する影響 JCSショック医療統計の分析(Prognostic Impact of Coronary Revascularization in Acute Coronary Syndrome Patients with Cardiogenic Shock: Analysis from the JCS Shock registry)

    的場 哲哉, 坂本 和生, 毛利 正博, 田中 信大, 外間 洋平, 福冨 基城, 羽柴 克孝, 福原 怜, 植木 康志, 諏訪 哲, 松浦 広英, 立花 栄三, 米本 直裕, 長尾 健, JCSショックレジストリ学術委員会

    日本心血管インターベンション治療学会抄録集   2016.7

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  • ACS

    J-ReSS   2016.5

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  • Knowing the Risks of the Vessels From the Vessels

    Tetsuya Matoba

    CIRCULATION JOURNAL   2016.4

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    DOI： 10.1253/circj.CJ-16-0164

  • Nanoparticle-mediated drug delivery system for coronary artery disease

    Tetsuya Matoba, Jun-Ichiro Koga, Kaku Nakano, Kensuke Egashira

    Drug Delivery System   2015.12

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    DOI： 10.2745/dds.30.299

  • Nanoparticle-mediated Simultaneous Targeting to Mitochondria and Inflammatory Monocytes Confers Additive Cardioprotection Against Myocardial Ischemia-reperfusion Injury

    Gentaro Ikeda, Tetsuya Matoba, Kensuke Egashira

    CIRCULATION   2015.11

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  • 急性心筋梗塞に対するナノDDSの開発

    的場 哲哉, 古賀 純一郎, 中野 覚

    最新医学   2015.11

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  • Nanoparticle-mediated Simultaneous Targeting to Mitochondria and Inflammatory Monocytes Confers Additive Cardioprotection Against Myocardial Ischemia-reperfusion Injury

    Gentaro Ikeda, Tetsuya Matoba, Ayako Ishikita, Kensuke Egashira

    CIRCULATION RESEARCH   2015.7

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  • Delivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Ulmonary Arterial Hypertension

    Satoshi Akagi, Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Hiromi Matsubara, Aiko Ogawa, Tetsuya Matoba, Kensuke Egashira, Hiroshi Ito

    International Heart Journal   2015.4

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    DOI： 10.1536/ihj.14-338

  • 冠動脈疾患治療を目指したナノ・ドラッグデリバリーシステムの開発

    的場 哲哉, 中野 覚, 江頭 健輔

    2015.3

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    冠動脈疾患、特に急性心筋梗塞は急性期死亡率の高さと慢性期の心不全の原因になることから、 その予防及び治療の改善は我が国の医学の重要な課題である。急性心筋梗塞で問題となる病態は冠 動脈における動脈硬化性プラークの不安定化と破綻であり、一方、発症した急性心筋梗塞における 問題は早期再灌流療法時に発生する心筋虚血再灌流傷害であり、再灌流療法による心筋梗塞縮小効 果を妨げる。これらの病態に対する薬物療法が研究されているが十分とは言えず、筆者らはナノ粒 子化技術を応用したドラッグデリバリーシステムを開発し、冠動脈疾患を含む心血管病における応 用を目指している。本稿ではその背景およびモデル動物における前臨床試験の成果を紹介する。

  • Nanoparticle-Mediated Simultaneous Targeting to Mitochondria and Inflammatory Monocytes Confers Additive Cardioprotection Against Myocardial Ischemia-Reperfusion Injury

    Gentaro Ikeda, Tetsuya Matoba, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2014.11

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  • Nanoparticles-Mediated Delivery of Pioglitazone Reduces Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-mediated Inflammation in Mice and Mini Pigs

    Masaki Tokutome, Tetsuya Matoba, Yasuhiro Nakano, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2014.11

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  • Nanoparticle-mediated Delivery of Pioglitazone Ameliorates Inflammation and Inhibits Atherosclerotic Plaque Rupture in Apolipoprotein-E Deficient Mice

    Soichi Nakashiro, Tetsuya Matoba, Jun-ichiro Koga, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2014.11

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  • Nanoparticle-Mediated Targeting of a Mitochondria Division Inhibitor, Mdivi-1, to the Mitochondria Induces Cardioprotection from Ischemia-Reperfusion Injury

    Ayako Ishikita, Tetsuya Matoba, Gentaro Ikeda, Yajing Mao, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2014.11

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  • Nanoparticle-Mediated Delivery of Pitavastatin into Small Pulmonary Arteies by Intravenous Administration Attenuated the Progression of Already Established Monocrotaline-induced Pulmonary Arterial Hypertension in Rats

    Kenzo Ichimura, Tetsuya Matoba, Ryoji Nagahama, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2014.11

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  • Nanoparticle-mediated targeting of pitavastatin into reperfused myocardium reduces ischemia-reperfusion injury in a preclinical pig model

    K. Ichimura, T. Matoba, K. Nakano, K. Nagaoka, K. Sunagawa, K. Egashira

    EUROPEAN HEART JOURNAL   2014.9

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  • Nanoparticle-mediated targeting of cyclosporine a to the mitochondria of reperfused myocardium enhances cardioprotection against ischemia-reperfusion injury in preclinical models

    G. Ikeda, T. Matoba, Y. Nakano, K. Nagaoka, K. Nakano, K. Sunagawa, K. Egashira

    EUROPEAN HEART JOURNAL   2014.9

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  • Nanoparticle-Mediated Drug Delivery System for Cardiovascular Disease

    Tetsuya Matoba, Egashira kensuke

    2014.8

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    Other Link： https://www.jstage.jst.go.jp/article/ihj/55/4/55_14-150/_pdf

  • Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes.

    Shunsuke Katsuki, Tetsuya Matoba, Soichi Nakashiro, Kei Sato, Jun-ichiro Koga, Kaku Nakano, Yasuhiro Nakano, Shizuka Egusa, Kenji Sunagawa, Kensuke Egashira

    Circulation   2014.2

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    DOI： 10.1161/CIRCULATIONAHA.113.002870

  • Nanoparticle-mediated drug delivery system for cardiovascular disease Reviewed

    Tetsuya Matoba, Kensuke Egashira

    International heart journal   2014.1

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    DOI： 10.1536/ihj.14-150

  • A Novel Rabbit Model of Plaque Erosion With Spontaneous Atherothrombotic Occlusion

    Yoshibumi Antoku, Tetsuya Matoba, Takeo Yufu, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2013.11

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  • Nanoparticle-Mediated Targeting of Pitavastatin Into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Pig Model

    Kenzo Ichimura, Kaku Nakano, Kazuhiro Nagaoka, Tetsuya Matoba, Shizuka Egusa, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2013.11

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  • Chest-Compression-Only Bystander Cardiopulmonary Resuscitation in the 30:2 Compression-to-Ventilation Ratio Era - Nationwide Observational Study -

    Ken Nagao, Hiroshi Nonogi, Naohiro Yonemoto, Singo Furuya, Sigemasa Tani, Naoya Matumoto, Morimasa Talcayama, Shinichi Shirai, Takeshi Kimura, Choukou Genka, Eizo Tachibana, Hiromi Seo, Hideharu Tanaka, Hiromi Seo, Hiroyuki Yokoyama, Kazuo Kimura, Keijiro Saku, Kunio Oota, Mamoru Hase, Migaku Kikuchi, Naoki Shimizu, Satoshi Takeda, Shigeru Kanesaka, Sunao Kojima, Takanori Ikeda, Taku Iwami, Tetsuya Matoba, Toshiaki Mano, Tetsuhisa Kitamura, Yoshihiko Seino, Yoshio Tahara

    CIRCULATION JOURNAL   2013.11

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    DOI： 10.1253/circj.CJ-13-0457

  • Mouse models of plaque rupture

    Tetsuya Matoba, Kei Sato, Kensuke Egashira

    CURRENT OPINION IN LIPIDOLOGY   2013.10

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    DOI： 10.1097/MOL.0b013e3283646e4d

  • A New Therapeutic Modality for Ischemia-Reperfusion Injury: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia/Reperfusion Injury in Rats

    Kazuhiro Nagaoka, Tetsuya Matoba, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2012.11

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  • Nanoparticle-Mediated Delivery of Pitavastatin Inhibits Plaque Destabilization and Rupture in the Brachiocephalic Arteries of ApoE-Deficient Mice through Regulating Monocyte Activation

    Shunsuke Katsuki, Tetsuya Matoba, Kei Sato, Jun-ichiro Koga, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2012.11

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  • An Unique Animal Model of Spontaneous Atherothrombotic Occlusion due to Plaque Erosion at Femoral Arteries of Atherosclerotic Rabbits Infused with Angiotension II

    Yoshibumi Antoku, Tetsuya Matoba, Takeo Yufu, Kaku Nakano, Kensuke Egashira

    CIRCULATION   2012.11

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  • A Novel Multi-Targeting Approach for Myocardial Ischemia-Reperfusion Injury: Nanoparticle-Mediated Delivery of Irbesartan Reduces Ischemia/Reperfusion Injury in Mice

    Yasuhiro Nakano, Tetsuya Matoba, Gentaro Ikeda, Kazuhiro Nagaoka, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2012.11

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  • Nanoparticle-mediated delivery of pioglitazone enhances therapeutic neovascularization in a murine model of hindlimb ischemia.

    Ryoji Nagahama, Tetsuya Matoba, Kaku Nakano, Shokei Kim-Mitsuyama, Kenji Sunagawa, Kensuke Egashira

    Arteriosclerosis, thrombosis, and vascular biology   2012.10

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    DOI： 10.1161/ATVBAHA.112.253823

  • インターネットクラウドを介した東日本大震災支援 循環器疾患患者応需情報マップ作成の経験

    的場 哲哉, 野々木 宏, 砂川 賢二

    臨床医のための循環器診療   2012.3

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  • Anti-Inflammatory Gene Therapy for Cardiovascular Disease

    Tetsuya Matoba, Kensuke Egashira

    CURRENT GENE THERAPY   2011.12

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    DOI： 10.2174/156652311798192888

  • A New Therapeutic Modality for Ischemia-Reperfusion Injury: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Myocardial Ischemia/Reperfusion Injury in Rats

    Kazuhiro Nagaoka, Tetsuya Matoba, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2011.11

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  • Intensive Lipid-Lowering Therapy by Pitavastatin Ameliorates Coronary Hypercontraction After Stenting, the CONTRACTION Study

    Tetsuya Matoba, Masao Takemoto, Susumu Takase, Shinobu Arai, Yasushi Mukai, Shujiro Inoue, Taiki Higo, James K. Liao, Kensuke Egashira, Kenji Sunagawa

    CIRCULATION   2011.11

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  • 不安定プラークと炎症 (特集 炎症・免疫からみた心血管病)

    香月 俊輔, 的場 哲哉, 中野 覚

    循環器内科   2011.6

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  • Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension.

    Ling Chen, Kaku Nakano, Satoshi Kimura, Tetsuya Matoba, Eiko Iwata, Miho Miyagawa, Hiroyuki Tsujimoto, Kazuhiro Nagaoka, Junji Kishimoto, Kenji Sunagawa, Kensuke Egashira

    Hypertension (Dallas, Tex. : 1979)   2011.2

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    DOI： 10.1161/HYPERTENSIONAHA.110.157032

  • NPC1L1 Inhibition with Ezetimibe Prevents Accelerated Plaque Destabilization and Rupture Induced by Dietary Cholesterol Oxidation Products in ApoE-deficient Mice

    Kei Sato, Tetsuya Matoba, Shunsuke Katsuki, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2010.11

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  • Nanoparticle-mediated Endothelial Cell-selective Delivery of Pioglitazone Enhances Therapeutic Efficacy of Therapeutic Angiogenesis and Arteriogenesis after Hindlimb Ischemia in Mice

    Ryoji Nagahama, Tetsuya Matoba, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2010.11

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  • Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Prevents Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in ApoE-Deficient Mice

    Shunsuke Katsuki, Tetsuya Matoba, Jun-ichiro Koga, Kaku Nakano, Kei Sato, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2010.11

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  • Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Inhibits Monocyte Activation and Attenuates Plaque Destabilization and Rupture in ApoE-Deficient Mice

    Shunsuke Katsuki, Tetsuya Matoba, Kaku Nakano, Kei Sato, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2010.11

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  • NPC1L1 Inhibition with Ezetimibe Suppresses Enhanced Formation of Aortic Atherosclerosis Induced by Dietary Cholesterol Oxidation Products in ApoE-deficient Mice

    Kei Sato, Tetsuya Matoba, Shunsuke Katsuki, Kaku Nakano, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2010.11

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  • Nanoparticle-mediated endothelial cell-selective delivery of pitavastatin induces functional collateral arteries (therapeutic arteriogenesis) in a rabbit model of chronic hind limb ischemia

    Shinichiro Oda, Ryoji Nagahama, Kaku Nakano, Tetsuya Matoba, Mitsuki Kubo, Kenji Sunagawa, Ryuji Tominaga, Kensuke Egashira

    JOURNAL OF VASCULAR SURGERY   2010.8

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    DOI： 10.1016/j.jvs.2010.03.020

  • ACSのEBMに基づく薬物療法：スタチン系

    的場哲哉, 江頭健輔

    2010.4

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  • Statins in the management of acute coronary syndrome

    Tetsuya Matoba, Kensuke Egashira

    Nippon rinsho. Japanese journal of clinical medicine   2010.4

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    Statins in the management of acute coronary syndrome
    HMG-CoA reductase inhibitors(statins) are widely used to treat dyslipidemia, and now play an important role in the management of acute coronary syndrome (ACS). Besides their lipid lowering effect, statins display &#039;pleiotropic effects&#039; that include improvement of nitric oxide bioavailability, inhibition of inflammatory cytokine expression and inhibition of blood coagulability, which may ameliorate the pathogenesis of ACS as shown in animal models and human studies. In clinical trials, statins are proven to reduce the risk of ACS in primary as well as secondary prevention, in which LDL cholesterol lowering correlates with the risk reduction for ACS. Recent trials suggested that the immediate initiation of statins benefit the ACS patients reducing recurrent ischemic events and improve prognosis. These evidences suggest that more aggressive statin treatment may benefit both low- and high-risk patients in the management of ACS.

  • High Incidence of Coronary Vasospasm After Sirolimus-Eluting Stent Implantation: Role of Rho-associated Kinase Activation

    Tetsuya Matoba, Masao Takemoto, Yasushi Mukai, Shujiro Inoue, Shinobu Kawamura-Arai, Kensuke Noma, Ryuji Okamoto, James K. Liao, Kenji Sunagawa

    CIRCULATION   2009.11

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  • Pitavastatin Incorporated Nanoparticle-eluting Stents Attenuate In-stent Stenosis Without Anti-healing Effects Induced by Sirolimus-eluting Stents (cypher) in Porcine Coronary Artery Model

    Noriaki Tsukie, Kensuke Egashira, Kaku Nakano, Tetsuya Matoba, Kenji Sunagawa

    CIRCULATION   2009.11

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    Language：English  

  • Ninoparticle-Mediated Delivery of Pioglitazone Effectively Attenuates Neointimal Formation After Wire Injury in Mice

    Takaharu Shirahama, Tetsuya Matoba, Ryoji Nagahama, Yamin Tian, Kaku Nakano, Hiroyuki Tsujimoto, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2009.11

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  • Nanoparticle-mediated Endothelial Cell-selective Delivery of Pioglitazone Improves Therapeutic Efficacy of Ischemic Neovascularization

    Ryoji Nagahama, Tetsuya Matoba, Kaku Nakano, Kaori Hara, Hiroyuki Tsujimoto, Kenji Sunagawa, Kensuke Egashira

    CIRCULATION   2009.11

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  • Nanoparticle-mediated delivery of angiotensin II receptor antagonist, olmesartan medoxomil into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

    L. Chen, K. Nakano, S. Kimura, T. Matoba, K. Sunagawa, K. Egashira

    INTERNATIONAL JOURNAL OF CARDIOLOGY   2009.10

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    DOI： 10.1016/j.ijcard.2009.09.500

  • Rotational atherectomy for calcified coronary stenosis in elderly patients with severe left ventricular dysfunction: Three case reports

    Masao Takemoto, Yoshisato Shibata, Ken Ichi Eshima, Yasushi Mukai, Shujiro Inoue, Yoji Sagara, Tetsuya Matoba, Hideo Tada, Kenji Sunagawa

    Japanese Journal of Interventional Cardiology   2009.8

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    Rotational atherectomy for calcified coronary stenosis in elderly patients with severe left ventricular dysfunction: Three case reports
    Rotational atherectomy (ROTA) is an effective modality of percutaneous coronary intervention (PCI) for calcified coronary stenoses. However, the manufacture dose not recommend the use of ROTA in patients with severe left ventricular (LV) dysfunction, especially with a LV ejection fraction of less than 30%. We experienced 3 elderly patients with severe LV dysfunction and an EF of less than 25%, who underwent ROTA for coronary calcified stenoses without any complications while taking appropriate measures before and during the PCI, and ultimately obtained excellent clinical courses.

  • Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms

    Kimio Satoh, Patrizia Nigro, Tetsuya Matoba, Michael R. O'Dell, Zhaoqiang Cui, Xi Shi, Amy Mohan, Chen Yan, Jun-ichi Abe, Karl A. Illig, Bradford C. Berk

    NATURE MEDICINE   2009.6

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    DOI： 10.1038/nm.1958

  • Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin Into the Vascular Endothelium

    Mitsuki Kubo, Kensuke Egashira, Takahiro Inoue, Jun-ichiro Koga, Shinichiro Oda, Ling Chen, Kaku Nakano, Tetsuya Matoba, Yoshiaki Kawashima, Kaori Hara, Hiroyuki Tsujimoto, Katsuo Sueishi, Ryuji Tominaga, Kenji Sunagawa

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   2009.6

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    DOI： 10.1161/ATVBAHA.108.182584

  • Formulation of Nanoparticle-Eluting Stents by a Cationic Electrodeposition Coating Technology Efficient Nano-Drug Delivery via Bioabsorbable Polymeric Nanoparticle-Eluting Stents in Porcine Coronary Arteries

    Kaku Nakano, Kensuke Egashira, Seigo Masuda, Kouta Funakoshi, Gang Zhao, Satoshi Kimura, Tetsuya Matoba, Katsuo Sueishi, Yasuhisa Endo, Yoshiaki Kawashima, Kaori Hara, Hiroyuki Tsujimoto, Ryuji Tominaga, Kenji Sunagawa

    JACC-CARDIOVASCULAR INTERVENTIONS   2009.4

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    DOI： 10.1016/j.jcin.2008.08.023

  • Soluble Flt-1 Gene Transfer Ameliorates Neointima Formation After Wire Injury in flt-1 Tyrosine Kinase-Deficient Mice

    Jun-ichiro Koga, Tetsuya Matoba, Kensuke Egashira, Mitsuki Kubo, Miho Miyagawa, Eiko Iwata, Katsuo Sueishi, Masabumi Shibuya, Kenji Sunagawa

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   2009.4

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    DOI： 10.1161/ATVBAHA.109.183772

  • プラーク破綻のナノ治療

    的場哲哉, 古賀純一郎, 江頭健輔

    2009.3

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  • PJ-336 Pitavastatin Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Stenosis, and Prevents Adverse Effects of Silorimus-Eluting Cypher Stent in Porcine Coronary Artery Model(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Tukie Noriaki, Egashira Kensuke, Kaku Nakano, Matoba Tetsuya, Sunagawa Kenji

    Circulation journal : official journal of the Japanese Circulation Society   2009.3

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    PJ-336 Pitavastatin Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Stenosis, and Prevents Adverse Effects of Silorimus-Eluting Cypher Stent in Porcine Coronary Artery Model(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  • OJ-212 Nanoparticle-Mediated Intracellular Delivery of Pitavastatin to Endothelial Progenitor Cells Ex Vivo Recovers the Functional Activity for Therapeutic Neovascularization(OJ36,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Kubo Mitsuki, Egashira Kensuke, Oda Shinichiro, Matoba Tetsuya, Hara Kaori, Tsujimoto Hiroyuki, Sunagawa Kenji

    Circulation journal : official journal of the Japanese Circulation Society   2009.3

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    OJ-212 Nanoparticle-Mediated Intracellular Delivery of Pitavastatin to Endothelial Progenitor Cells Ex Vivo Recovers the Functional Activity for Therapeutic Neovascularization(OJ36,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  • OE-298 Cyclophilin A Promotes Vascular Oxidative Stress and Accelerates Development of Angiotensin II-induced Aortic Aneurysms(OE51,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Satoh Kimio, Nigro Patrizia, Matoba Tetsuya, Shimokawa Hiroaki, Berk Bradford C.

    Circulation journal : official journal of the Japanese Circulation Society   2009.3

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    OE-298 Cyclophilin A Promotes Vascular Oxidative Stress and Accelerates Development of Angiotensin II-induced Aortic Aneurysms(OE51,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  • OE-293 Mechanisms Underlying Coronary Vasopsasm at Distal Arterial Segments of Sirolimus-Eluting Stent Implantation in a Porcine Model(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Matoba Tetsuya, Egashira Kensuke, Masuda Seigo, Iwata Eiko, Miyagawa Miho, Nakano Kaku, Tukie Noriaki, Sunagawa Kenji

    Circulation journal : official journal of the Japanese Circulation Society   2009.3

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    OE-293 Mechanisms Underlying Coronary Vasopsasm at Distal Arterial Segments of Sirolimus-Eluting Stent Implantation in a Porcine Model(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  • OE-059 Cholesterol-lowering Therapy with the Cholesterol Absorption Inhibitor Ezetimibe Inhibits Plaque Destabilization and Rupture in the Brachiocephalic Arteries of ApoE-deficient Mice(OE10,Atherosclerosis, Basic 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Sato Kei, Egashira Kensuke, Katsuki Shunsuke, Matoba Tetsuya, Sunagawa Kenji

    Circulation journal : official journal of the Japanese Circulation Society   2009.3

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    OE-059 Cholesterol-lowering Therapy with the Cholesterol Absorption Inhibitor Ezetimibe Inhibits Plaque Destabilization and Rupture in the Brachiocephalic Arteries of ApoE-deficient Mice(OE10,Atherosclerosis, Basic 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  • アンジオテンシン2による炎症と内皮機能障害 (第5土曜特集 レニン・アンジオテンシン系のすべて) -- (RASの病態生理)

    的場 哲哉, 古賀 純一郎, 江頭 健輔

    医学のあゆみ   2009.1

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  • Cyclophilin a Promotes Vascular Oxidative Stress and Accelerates Development of Angiotensin II-Induced Aortic Aneurysms

    Kimio Satoh, Patrizia Nigro, Tetsuya Matoba, Michael R. O'Dell, Zhaoqiang Cui, Xi Shi, Amy Mohan, Chen Yan, Jun-ichi Abe, Bradford C. Berk

    CIRCULATION   2008.10

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  • Nanoparticle-based Monocyte-Selective Delivery of PPAR gamma Agonist Pioglitazone Inhibits Plaque Rupture In ApoE-Deficient Mice

    Tetsuya Matoba, Kensuko Egashira, Jun-ichiro Koga, Kaori Hara, Hiroyuki Tsujimoto, Kenji Sunagawa

    CIRCULATION   2008.10

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  • Nanoparticle-Mediated Monocyte-Selective Transfection of Dominant-Negative Monocyte Chemoattractant Protein-1 (MCP-1) Gene Inhibits Plaque Rupture in ApoE-Deficient Mice

    Jun-ichiro Koga, Kensuke Egashira, Tetsuya Matoba, Kaori Hara, Hiroyuki Tsujimoto, Kenji Sunagawa

    CIRCULATION   2008.10

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  • Mechanisms Underlying Coronary Vasopsasm at Distal Arterial Segments of Sirolimus-Eluting Stent Implantation In a Porcine Model

    Tetsuya Matoba, Kensuke Egashira, Seigo Masuda, Eiko Iwata, Miho Miyagawa, Kaku Nakano, Noriaki Tsukie, Kenji Sunagawa

    CIRCULATION   2008.10

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  • Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.

    Kimio Satoh, Tetsuya Matoba, Jun Suzuki, Michael R O'Dell, Patrizia Nigro, Zhaoqiang Cui, Amy Mohan, Shi Pan, Lingli Li, Zheng-Gen Jin, Chen Yan, Jun-ichi Abe, Bradford C Berk

    Circulation   2008.6

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    DOI： 10.1161/CIRCULATIONAHA.107.756106

  • 160) 血行動態不安定なwide QRS頻拍を呈し,カテーテルアブレーションで根治し得た心房頻拍の1例(第103回日本循環器学会九州地方会)

    香月 俊輔, 的場 哲哉, 向井 靖, 江島 健一, 多田 英生, 竹本 真生, 砂川 賢二

    2008.4

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  • FRS-029 Monocyte-Targeting Nanoparticle-Based Delivery of Anti-Monocyte Chemoattractant Protein-1 Gene Inhibits Plaque Rupture of Brachiocephalic Arteries in Apolipoprotein-E Deficient Mice(Novel Mechanisms in Atherosclerosis (IHD),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Koga Junichiro, Matoba Tetsuya, Egashira Kensuke, Hara Kaori, Tsujimoto Hiroyuki, Sueishi Katsuo, Sunagawa Kenji

    Circulation journal : official journal of the Japanese Circulation Society   2008.3

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    FRS-029 Monocyte-Targeting Nanoparticle-Based Delivery of Anti-Monocyte Chemoattractant Protein-1 Gene Inhibits Plaque Rupture of Brachiocephalic Arteries in Apolipoprotein-E Deficient Mice(Novel Mechanisms in Atherosclerosis (IHD),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  • OE-188 Monocyte-targeting Nanoparticle-based Delivery of Pioglitazone Inhibits Plaque Rupture in the Brachiocephalic Arteries of Apolipoprotein-E Deficient Mice(Atherosclerosis, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Koga Jun-ichiro, Matoba Tetsuya, Egashira Kensuke, Hara Kaori, Tsujimoto Hiroyuki, Sueishi Katsuo, Sunagawa Kenji

    Circulation journal : official journal of the Japanese Circulation Society   2008.3

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    OE-188 Monocyte-targeting Nanoparticle-based Delivery of Pioglitazone Inhibits Plaque Rupture in the Brachiocephalic Arteries of Apolipoprotein-E Deficient Mice(Atherosclerosis, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  • ケモカインと動脈硬化 (第5土曜特集 Vascular Biology Update) -- (血管傷害の分子機序)

    的場 哲哉, 古賀 純一郎, 江頭 健輔

    医学のあゆみ   2007.12

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  • Cyclophilin a mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation

    Kimio Satoh, Tetsuya Matoba, Michael O'Dell, Lingli Li, Jun Suzuki, Shi Pan, Sarah Mack, Amy Mohan, Zheng-Gen Jin, Joseph M. Milano, Jun-ichi Abe, Bradford C. Berk

    CIRCULATION   2007.10

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  • 62)PDEIII-IおよびEPO併用下にβ遮断薬導入に成功した難治性心不全の症例(第102回日本循環器学会九州地方会)

    斉藤 寿郎, 的場 哲哉, 岸 拓弥, 井手 友美, 戸高 浩司, 廣岡 良隆, 砂川 賢二

    2007.10

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  • Vascular endothelial growth factor accelerates neointima formation through flk-1 after wire injury in flt-1 tyrosine kinase-deficient mice

    Jun-ichiro Koga, Kensuke Egashira, Tetsuya Matoba, Masabumi Shibuya, Kenji Sunagawa

    CIRCULATION   2007.10

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  • VEGF accelerates neointima formation through flk-1 after wire injury in flt-1 tyrosine kinase-deficient mice

    Jun-ichiro Koga, Kensuke Egashira, Tetsuya Matoba, Masabumi Shibuya, Kenji Sunagawa

    HYPERTENSION   2007.10

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  • Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.

    Jun Suzuki, Zheng-Gen Jin, David F Meoli, Tetsuya Matoba, Bradford C Berk

    Circulation research   2006.3

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    DOI： 10.1161/01.RES.0000216405.85080.a6

  • Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.

    Yoshihiro Fukumoto, Akira Ito, Toyokazu Uwatoku, Tetsuya Matoba, Takuya Kishi, Haruki Tanaka, Akira Takeshita, Kenji Sunagawa, Hiroaki Shimokawa

    Coronary artery disease   2006.2

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    DOI： 10.1097/00019501-200602000-00011

  • 非侵襲性体外衝撃波療法は重症虚血性心臓病患者の心筋虚血を改善する

    福本 義弘, 下川 宏明, 伊藤 昭, 上徳 豊和, 的場 哲哉, 岸 拓弥, 田中 玄紀, 砂川 賢二, 竹下 彰

    2006.2

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  • HMG-CoA reductase inhibitor attenuates reactive oxygen species-induced cyclophilin a secretion in vascular smooth muscle cells: Role for actin and Rho GTPases

    J Suzuki, T Matoba, ZG Jin, BC Berk

    CIRCULATION   2005.10

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  • Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated responses in mice.

    Keiko Morikawa, Tetsuya Matoba, Hiroshi Kubota, Makoto Hatanaka, Takako Fujiki, Shosuke Takahashi, Akira Takeshita, Hiroaki Shimokawa

    Journal of cardiovascular pharmacology   2005.5

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    DOI： 10.1097/01.fjc.0000159657.93922.cb

  • Endothelium-derived hydrogen peroxide accounts for the enhancing effect of an angiotensin-converting enzyme inhibitor on endothelium-derived hyperpolarizing factor-mediated responses in mice.

    Takako Fujiki, Hiroaki Shimokawa, Keiko Morikawa, Hiroshi Kubota, Makoto Hatanaka, M A Hassan Talukder, Tetsuya Matoba, Akira Takeshita, Kenji Sunagawa

    Arteriosclerosis, thrombosis, and vascular biology   2005.4

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    DOI： 10.1161/01.ATV.0000158498.19027.75

  • Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

    Y Fukumoto, T Matoba, A Ito, H Tanaka, T Kishi, S Hayashidani, K Abe, A Takeshita, H Shimokawa

    HEART   2005.3

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    DOI： 10.1136/hrt.2003.029470

  • Endothelium-Derived Hydrogen Peroxide Accounts for the Enhancing Effect of an ACE Inhibitor on EDHF-Mediated Responses in Mice(Endothelium/NO 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Fujiki Takako, Shimokawa Hiroaki, Morikawa Keiko, Kubota Hiroshi, Hatanaka Makoto, Hassan Talukder M. A., Matoba Tetsuya, Takeshita Akira, Sunagawa Kenji

    Circulation journal : official journal of the Japanese Circulation Society   2005.3

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    Endothelium-Derived Hydrogen Peroxide Accounts for the Enhancing Effect of an ACE Inhibitor on EDHF-Mediated Responses in Mice(Endothelium/NO 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  • Important role of superoxide dismutase in EDHF-mediated responses of human mesenteric arteries.

    Keiko Morikawa, Takako Fujiki, Tetsuya Matoba, Hiroshi Kubota, Makoto Hatanaka, Shosuke Takahashi, Hiroaki Shimokawa

    Journal of cardiovascular pharmacology   2004.11

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    DOI： 10.1097/00005344-200411000-00006

  • Endothelium-derived hydrogen peroxide accounts for the enhanced EDHF-mediated relaxation by long-term treatment with an angiotensin-converting enzyme inhibitor in mice

    T Fujiki, M Hatanaka, K Morikawa, H Kubota, T Matoba, MAH Talukder, H Shimokawa

    CIRCULATION   2004.10

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  • Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated relaxations in mice

    K Morikawa, H Kubota, T Matoba, T Fujiki, M Hatanaka

    CIRCULATION   2004.10

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  • Important role of superoxide dismutase in EDHF-mediated relaxations of human mesenteric arteries

    K Morikawa, H Kubota, T Matoba, T Fujiki, M Hatanaka, H Shimokawa

    CIRCULATION   2004.10

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  • Usefulness of fasudil, a rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery

    K Inokuchi, A Ito, Y Fukumoto, T Matoba, A Shiose, T Nishida, M Masuda, S Morita, H Shimokawa

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   2004.9

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    DOI： 10.1097/01.fjc.0000134775.76636.3f

  • Endothelial Cu,Zn-SOD plays a pivotal role in endothelium-dependent hyperpolarization in mice

    K Morikawa, H Kubota, T Matoba, M Hatanaka, T Fujiki, MAH Talukder, T Akaike, H Maeda, H Shimokawa

    NITRIC OXIDE-BIOLOGY AND CHEMISTRY   2004.8

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    DOI： 10.1016/j.niox.2004.07.003

  • Important role of superoxide dismutase in EDHF-mediated relaxations of human mesenteric arteries

    K Morikawa, H Kubota, T Matoba, M Hatanaka, T Fujiki, MAH Talukder, H Shimokawa

    NITRIC OXIDE-BIOLOGY AND CHEMISTRY   2004.8

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  • Endothelium-derived hydrogen peroxide accounts for the enhanced EDHF-mediated relaxations by long-term treatment with an angiotensin converting enzyme inhibitor in mice

    T Fujiki, H Kubota, M Hatanaka, K Morikawa, MAH Talukder, T Matoba, H Shimokawa

    NITRIC OXIDE-BIOLOGY AND CHEMISTRY   2004.8

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  • Hydrogen peroxide as an endothelium-derived hyperpolarizing factor

    H Shimokawa, T Matoba

    PHARMACOLOGICAL RESEARCH   2004.6

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    DOI： 10.1016/j.phrs.2003.10.016

  • FRS-079 Endothelial Cu,Zn-SOD Plays a Pivotal Role in Endothelium-Dependent Hyperpolarization in Mice(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English))

    Morikawa Keiko, Matoba Tetsuya, Kubota Hiroshi, Hatanaka Makoto, Fujiki Takako, Hassan Talukder M. A, Shimokawa Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society   2004.3

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    FRS-079 Endothelial Cu,Zn-SOD Plays a Pivotal Role in Endothelium-Dependent Hyperpolarization in Mice(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English))

  • OE-303 Hydorogen Peroxide Is an Endothelium-Derived Hyperpolaring Factor (EDHF) Involved in the Beneficial Effect of an ACE Inhibitorin Mice(Endothelium/NO 4 (H) : OE38)(Oral Presentation (English))

    Fujiki Takako, Kubota Hiroshi, Morikawa Keiko, Hatanaka makkoto, Matoba Tetsuya, Hassan Talukder M. A., Shimokawa Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society   2004.3

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    OE-303 Hydorogen Peroxide Is an Endothelium-Derived Hyperpolaring Factor (EDHF) Involved in the Beneficial Effect of an ACE Inhibitorin Mice(Endothelium/NO 4 (H) : OE38)(Oral Presentation (English))

  • PJ-180 Usefulness of Fasudil, a Rho-Kinase Inhibitor, to Treat Intractable Severe Vasopasm After Coronary Artery Bypass Surgery(Cardiovascular Surgery/CABG 2 (IHD) : PJ31)(Poster Session (Japanese))

    Inokuchi Kosuke, Ito Akira, Fukumoto Yoshihiro, Matoba Tetsuya, Shiose Akira, Nishida Takahiro, Masuda Munetaka, Morita Shigeki, Shimokawa Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society   2004.3

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    PJ-180 Usefulness of Fasudil, a Rho-Kinase Inhibitor, to Treat Intractable Severe Vasopasm After Coronary Artery Bypass Surgery(Cardiovascular Surgery/CABG 2 (IHD) : PJ31)(Poster Session (Japanese))

  • OE-305 Important Role of Superoxide Dismutase in EDHF-Mediated Relaxations of Human Mesenteric Arteries(Endothelium/NO 4 (H) : OE38)(Oral Presentation (English))

    Morikawa Keiko, Kubota Hiroshi, Matoba Tetsuya, Hatanaka Makoto, Fujiki Takako, Hassan Talukder M. A., Shimokawa Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society   2004.3

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    OE-305 Important Role of Superoxide Dismutase in EDHF-Mediated Relaxations of Human Mesenteric Arteries(Endothelium/NO 4 (H) : OE38)(Oral Presentation (English))

  • Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization

    K Morikawa, H Shimokawa, T Matoba, H Kubota, T Akaike, MAH Talukder, M Hatanaka, T Fujiki, H Maeda, S Takahashi, A Takeshita

    JOURNAL OF CLINICAL INVESTIGATION   2003.12

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    DOI： 10.1172/JCI200319351

  • Advanced Cardiovascular Life Support (ACLS)

    Tetsuya Matoba

    Respiration and Circulation   2003.11

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    Advanced Cardiovascular Life Support (ACLS)

  • Endothelium-derived hydrogen peroxide accounts for the improved EDHF-mediated relaxations caused by long-term treatment with an angiotensin converting enzyme inhibitor in mice

    T Fujiki, H Kubota, K Morikawa, T Matoba, MAH Talukder, M Hatanaka, H Shimokawa

    CIRCULATION   2003.10

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  • Off-pump CABG直後に発症した重症冠動脈れん縮に対しPho-kinase inhibitorが著効した一症例(第94回日本循環器学会九州地方会)

    西田 誉浩, 益田 宗孝, 富田 幸裕, 徳永 〓彦, 田ノ〓 禎久, 塩瀬 明, 森田 茂樹, 伊藤 昭, 多田 英生, 的場 哲哉, 臼井 真, 毛利 正博, 下川 宏明

    2003.10

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  • Rho-kinase inhibitor, fasudil, reduces pulmonary vascular resistance in patients with severe pulmonary hypertension

    Y Fukumoto, T Matoba, K Abe, A Ito, H Shimokawa

    CIRCULATION   2003.10

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  • Acute vasodilator effects of HMG-CoA reductase inhibitors: involvement of PI3-kinase/Akt pathway and Kv channels.

    Yasushi Mukai, Hiroaki Shimokawa, Tetsuya Matoba, Junko Hiroki, Ikuko Kunihiro, Takako Fujiki, Akira Takeshita

    Journal of cardiovascular pharmacology   2003.7

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    DOI： 10.1097/00005344-200307000-00018

  • Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels

    T Matoba, H Shimokawa, K Morikawa, H Kubota, Kunihiro, I, L Urakami-Harasawa, Y Mukai, Y Hirakawa, T Akaike, A Takeshita

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   2003.7

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    DOI： 10.1161/01.ATV.0000078601.79536.6C

  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans

    T Matoba, H Shimokawa

    JOURNAL OF PHARMACOLOGICAL SCIENCES   2003.5

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    DOI： 10.1254/jphs.92.1

  • 血管トーヌス制御 (血管医学 4)

    下川宏明, 的場哲哉

    血管医学 4   2003.4

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    Language：Japanese  

  • Influence of Diabetes Mellitus, Hypercholesterolemia, or Their Combination on Endothelium-Derived Hyperpolarizing Factor (EDHF)-Mediated Relaxations in Mice

    Morikawa Keiko, Shimokawa Hiroaki, Fujiki Takako, Kubota Hiroshi, Matoba Tetsuya, Hassan Talukder M.A., Hirakawa Yoji, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2003.3

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    Language：English  

    Influence of Diabetes Mellitus, Hypercholesterolemia, or Their Combination on Endothelium-Derived Hyperpolarizing Factor (EDHF)-Mediated Relaxations in Mice

  • Important Role of Cu/Zn-SOD in the Synthesis of Endothelium-Derived Hyperpolarizing Factor (EDHF) in Mice

    Morikawa Keiko, Shimokawa Hiroaki, Matoba Tetsuya, Kubota Hiroshi, Fujiki Takako, Hassan Talukder M.A., Hirakawa Yoji, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2003.3

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    Language：English  

    Important Role of Cu/Zn-SOD in the Synthesis of Endothelium-Derived Hyperpolarizing Factor (EDHF) in Mice

  • Involvement of neuronal NO synthase in NO-cGMP-mediated pathway in the maintenance of bradykinin-induced coronary flow in endothelial NO synthase knockout mice

    MAH Talukder, H Shimokawa, T Fujiki, K Morikawa, H Kubota, T Matoba, A Takeshita

    FASEB JOURNAL   2003.3

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    Language：English  

  • Involvement of Endothelial NO Synthase-Independent Mechanismin the Beneficial Effects of ACE Inhibitor on Coronary Endothelial Functions in Mice

    Talukder M.A. Hassan, Shimokawa Hiroaki, Morikawa Keiko, Fujiki Takako, Kubota Hiroshi, Kunihiro Ikuko, Matoba Tetsuya, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2003.3

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    Language：English  

    Involvement of Endothelial NO Synthase-Independent Mechanismin the Beneficial Effects of ACE Inhibitor on Coronary Endothelial Functions in Mice

  • Identification of Hydrogen Peroxide as an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans

    Matoba Tetsuya, Shimokawa Hiroaki, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2003.3

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    Language：English  

    Identification of Hydrogen Peroxide as an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans

  • Compensatory Role of Neuronal NO Synthase in Maintaining Coronary Flow in the Absence of Endothelial NO Synthase in Mice

    Talukder M.A. Hassan, Shimokawa Hiroaki, Fujiki Takako, Morikawa Keiko, Kubota Hiroshi, Matoba Tetsuya, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2003.3

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    Language：English  

    Compensatory Role of Neuronal NO Synthase in Maintaining Coronary Flow in the Absence of Endothelial NO Synthase in Mice

  • Important role of Cu/Zn-SOD in the synthesis of endothelium-derived hyperpolarizing factor (EDHF) in mice

    K Morikawa, T Matoba, H Kubota, T Fujiki, MAH Talukder, Y Hirakawa, H Shimokawa

    CIRCULATION   2002.11

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    Language：English  

  • Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats

    Y Mukai, H Shimokawa, M Higashi, K Morikawa, T Matoba, J Hiroki, Kunihiro, I, HMA Talukder, A Takeshita

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   2002.9

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    Language：English  

    DOI： 10.1161/01.ATV.0000029121.63691.CE

  • H2O2による血管調節機能 —内皮由来過分極因子としてのH2O2- (医学のあゆみ 8)

    的場哲哉, 下川宏明

    医学のあゆみ 8   2002.4

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    Language：Japanese  

  • 内皮由来過分極因子としての過酸化水素 (血管医学 3)

    的場哲哉, 下川宏明

    血管医学 3   2002.4

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    Language：Japanese  

  • Possible involvement of Cu/Zn-SOD in the synthesis of endothelium-derived hyperpolarizing factor (EDHF) in mice

    Matoba Tetsuya, Shimokawa Hiroaki, Morikawa Keiko, Kubota Hiroshi, Fujiki Takako, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2002.3

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    Language：English  

    Possible involvement of Cu/Zn-SOD in the synthesis of endothelium-derived hyperpolarizing factor (EDHF) in mice

  • Evidence for heterogeneity of the nature of endothelium-derived hyperpolarizing factors (EDHF) in porcine coronary arteries

    Matoba Tetsuya, Shimokawa Hiroaki, Kubota Hiroshi, Kunihiro Ikuko, Morikawa Keiko, Fujiki Takako, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2002.3

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    Language：English  

    Evidence for heterogeneity of the nature of endothelium-derived hyperpolarizing factors (EDHF) in porcine coronary arteries

  • Novel mechanisms for acute vasodilating effects of statins : Multiple actions on the endothelium and vascular smooth muscle cells

    Mukai Yasushi, Shimokawa Hiroaki, Matoba Tetsuya, Hiroki Junko, Fujiki Takako, Kunihiro Ikuko, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2002.3

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    Language：English  

    Novel mechanisms for acute vasodilating effects of statins : Multiple actions on the endothelium and vascular smooth muscle cells

  • Inhibition of renin-angiotensin system ameliorates endothelial dysfunction with aging in rats

    Mukai Yasushi, Shimokawa Hiroaki, Matoba Tetsuya, Hiroki Junko, Higashi Midoriko, Kunihiro Ikuko, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2002.3

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    Language：English  

    Inhibition of renin-angiotensin system ameliorates endothelial dysfunction with aging in rats

  • Identification of endothelium-derived hyperpolarizing factor : an evolving concept on endothelium-derived relaxing factors

    Shimokawa Hiroaki, Matoba Tetsuya, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2002.3

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    Language：English  

    Identification of endothelium-derived hyperpolarizing factor : an evolving concept on endothelium-derived relaxing factors

  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor (EDHF) in human mesenteric arteries

    Matoba Tetsuya, Shimokawa Hiroaki, Kubota Hiroshi, Morikawa Keiko, Fujiki Takako, Takeshita Akira

    Circulation journal : official journal of the Japanese Circulation Society   2002.3

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    Language：English  

    Hydrogen peroxide is an endothelium-derived hyperpolarizing factor (EDHF) in human mesenteric arteries

  • Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.

    Tadashi Kandabashi, Hiroaki Shimokawa, Yasushi Mukai, Tetsuya Matoba, Ikuko Kunihiro, Keiko Morikawa, Masaaki Ito, Shosuke Takahashi, Kozo Kaibuchi, Akira Takeshita

    Arteriosclerosis, thrombosis, and vascular biology   2002.2

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    Language：English  

    DOI： 10.1161/hq0202.104274

  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.

    Tetsuya Matoba, Hiroaki Shimokawa, Hiroshi Kubota, Keiko Morikawa, Takako Fujiki, Ikuko Kunihiro, Yasushi Mukai, Yoji Hirakawa, Akira Takeshita

    Biochemical and biophysical research communications   2002.1

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    Language：English  

    DOI： 10.1006/bbrc.2001.6278

  • Acute vasodilating effects of statins - A novel concept on their pharmacological actions-

    Y Mukai, T Matoba, J Hiroki, T Kandabashi

    CIRCULATION   2001.10

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    Language：English  

  • Rho-kinase plays an important role for vascular smooth muscle contraction of atherosclerotic human arteries

    T Kandabashi, Kunihiro, I, Y Mukai, T Matoba, K Morikawa, H Shimokawa

    CIRCULATION   2001.10

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    Language：English  

  • Long-term inhibition of Rho-kinase suppresses angiotensin II-induced formation of coronary vascular lesions and cardiac hypertrophy in rats in vivo

    M Higashi, Y Mukai, T Matoba, J Hiroki, Kunihiro, I, H Shimokawa

    CIRCULATION   2001.10

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    Language：English  

  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor (EDHF) in human mesenteric arteries

    T Matoba, H Kubota, Kunihiro, I, K Morikawa, Y Mukai, Y Hirakawa

    CIRCULATION   2001.10

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    Language：English  

  • Evidence for heterogeneity of the nature of endothelium-derived hyperpolarizing factors in porcine coronary arteries

    T Matoba, H Kubota, Y Mukai, Kunihiro, I, K Morikawa, Y Hirakawa, H Shimokawa

    CIRCULATION   2001.10

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    Language：English  

  • Does EDHF contribute to the control of peripehral resistance? (Dialogues Cardiovasc Med)

    Shimokawa H, Matoba T

    Dialogues Cardiovasc Med   2001.9

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    Language：English  

    Does EDHF contribute to the control of peripehral resistance? (Dialogues Cardiovasc Med)

  • Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.

    Y. Mukai, H. Shimokawa, T. Matoba, T. Kandabashi, S. Satoh, J. Hiroki, K. Kaibuchi, A. Takeshita

    The FASEB journal : official publication of the Federation of American Societies for Experimental Biology   2001.4

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    Language：Others  

    Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.

  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice

    T Matoba, H Shimokawa, M Nakashima, Y Hirakawa, Y Mukai, K Hirano, H Kanaide, A Takeshita

    JOURNAL OF CLINICAL INVESTIGATION   2000.12

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    Language：English  

  • Hydrogen peroxide derived from endothelial nitric oxide synthase is an endothelium-derived hyperpolarizing factor (EDHF) in mice

    T Matoba, H Shimokawa, M Nakashima, Y Mukai, A Takeshita

    CIRCULATION   2000.10

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    Language：English  

  • 0264 内皮由来過分極因子(EDHF)は内皮型NO合成酵素(eNOS)由来の非NO物質である可能性 : eNOSノックアウトマウスにおける検討

    的場 哲哉, 下川 宏明, 平川 洋二, 竹下 彰, 中島 幹夫, 平野 勝也, 金出 英夫

    2000.3

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    Language：Japanese  

  • Endothelium-derived hyperpolarizing factor (EDHF) is an endothelial nitric oxide synthase (eNOS)-Derived non-NO factor in mice

    T Matoba, H Shimokawa, Kunihiro, I, M Nakashima

    CIRCULATION   1999.11

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    Language：English  

  • 0922 内皮由来過分極因子(EDHF)は内皮型NO合成酵素(eNOS)由来の非NO物質である可能性 : eNOSノックアウトマウスにおける検討

    的場 哲哉, 下川 宏明, 国広 育子, 江頭 健輔, 竹下 彰, 中島 幹夫

    1999.3

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  • NOとEDHF (循環器科 44)

    的場哲哉, 下川宏明

    循環器科 44   1998.4

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    Language：Japanese  

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Professional Memberships

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

  • The Japanese Circulation Society

  • Japanese Association of Cardiovascular Intervention and Therapeutics

  • American Heart Association

  • 日本血管生物医学会

  • Japanese Heart Rhythm Society

  • JAPAN ATHEROSCLEROSIS SOCIETY

  • JAPANESE HEART RHYTHM SOCIETY

  • JAPANESE HEART FAILURE SOCIETY

  • Japanese College of Cardiology

  • JAPANESE ASSOCIATION OF CARDIOVASCULAR INTERVENTION AND THERAPEUTICS

  • European Society of Cardiology

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Committee Memberships

  • Executive   Domestic

    2022.4 - 2024.3   

  • Fellow (FESC)   Foreign country

    2021.1 - 2023.12   

  • Councilor   Domestic

    2020.4 - 2024.3   

  • Fellow (FJCS)   Domestic

    2018.4 - 2024.3   

  • Councilor   Domestic

    2014.4 - 2024.3   

  • 日本心血管インターベンション治療学会   代議員   Domestic

    2014.4 - 2024.3   

  • Fellow of AHA   Foreign country

    2013.5 - 2024.12   

  • Councilor   Domestic

    2010.4 - 2023.3   

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Academic Activities

  • 事務局長 International contribution

    第87回日本循環器学会学術集会総会  （ 福岡国際会議場 ） 2023.3

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    Type：Competition, symposium, etc. 

    Number of participants：15,000

  • Screening of academic papers

    Role(s)： Peer review

    2023

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：11

  • Circulation Reports International contribution

    2022.4 - 2024.3

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    Type：Academic society, research group, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2021

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：27

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：31

  • その他

    画像動体学会  （ 久留米 Japan ） 2019.1

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    Type：Competition, symposium, etc. 

    Number of participants：400

  • Screening of academic papers

    Role(s)： Peer review

    2019

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：22

  • その他 International contribution

    ISHR 国際心臓研究会  （ 東京 Japan ） 2018.12

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    Type：Competition, symposium, etc. 

    Number of participants：800

  • その他 International contribution

    （ 東京 Japan ） 2018.10

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    Type：Competition, symposium, etc. 

    Number of participants：500

  • その他 International contribution

    BCVR 日本循環器学会基礎研究シンポジウム  （ 奈良 Japan ） 2018.9

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    Type：Competition, symposium, etc. 

    Number of participants：500

  • その他

    日本循環器学会九州地方会  （ 鹿児島 Japan ） 2018.6

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    Type：Competition, symposium, etc. 

    Number of participants：400

  • その他

    福博循環器セミナー  （ 福岡 Japan ） 2018.4

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    Type：Competition, symposium, etc. 

    Number of participants：100

  • Screening of academic papers

    Role(s)： Peer review

    2018

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：24

  • Other International contribution

    Bifurcation symposium  （ Fukuoka Japan Japan ） 2017.4

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    Type：Competition, symposium, etc. 

  • その他 International contribution

    日本循環器学会総会  （ 金沢 Japan ） 2017.3

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    Type：Competition, symposium, etc. 

  • その他

    日本老年医学会九州地方会  （ 福岡市 Japan ） 2017.3

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2017

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：20

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • その他

    日本心血管インターベンション学会九州沖縄地方会  （ 福岡市 Japan ） 2016.8

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    Type：Competition, symposium, etc. 

  • その他

    日本循環器学会九州地方会  （ 大分市 Japan ） 2016.6

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    Type：Competition, symposium, etc. 

  • その他 International contribution

    日本循環器学会  （ 大阪 Japan ） 2015.4

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    Type：Competition, symposium, etc. 

  • International Heart Journal International contribution

    2015.4 - 2017.4

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    Type：Academic society, research group, etc. 

  • その他

    （ 福岡 Japan ） 2014.11

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    Type：Competition, symposium, etc. 

    Number of participants：50

  • その他

    （ 福岡 Japan ） 2014.10

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    Type：Competition, symposium, etc. 

  • その他

    （ 神戸 Japan ） 2014.9

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    Type：Competition, symposium, etc. 

    Number of participants：150

  • その他 International contribution

    日本動脈硬化学会  （ 東京 Japan ） 2014.7

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    Type：Competition, symposium, etc. 

  • その他

    日本循環器学会九州地方会  （ 福岡 Japan ） 2014.6

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    Type：Competition, symposium, etc. 

  • その他

    （ 福岡 Japan ） 2014.6

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    Type：Competition, symposium, etc. 

  • その他 International contribution

    日本動脈硬化学会  （ 東京、京王プラザホテル Japan ） 2013.7

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    Type：Competition, symposium, etc. 

  • その他

    第7回QcVIC  （ 福岡 Japan ） 2013.2

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    Type：Competition, symposium, etc. 

  • その他

    第6回QcVIC  （ 福岡 Japan ） 2012.9

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    Type：Competition, symposium, etc. 

  • その他

    （ 北海道 Japan ） 2012.9

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    Type：Competition, symposium, etc. 

  • その他 International contribution

    日本動脈硬化学会  （ 福岡ヒルトンシーホーク Japan ） 2012.7

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    Type：Competition, symposium, etc. 

  • Other

    Molecular Cardiovascular Conference II  （ Japan Japan ） 2011.9

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    Type：Competition, symposium, etc. 

  • その他

    （ 北海道 Japan ） 2010.9

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    Type：Competition, symposium, etc. 

  • その他

    （ 北海道 Japan ） 2009.9 - 2015.9

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    Type：Competition, symposium, etc. 

    Number of participants：200

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Research Projects

  • 戦略的イノベーション創造プログラム（SIP）

    2023.9 - 2027.3

    国立国際医療研究センター（日本） 

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    Authorship：Principal investigator 

    医療・ヘルスケア版 Society5.0構想は、情報技術の進歩により人間の身体と生理機能、行動をデータ化し、個別化された予防と医療を提供することを目指している。その実現のためには、医療に関わるあらゆる電子データを標準形式化したコピー「医療デジタルツイン」を形成し活用できる環境が必要である。厚生労働省による医療情報の交換・共有を促進するSS-MIX規格は800以上の医療機関が導入している。しかし、疾患に特化した診療情報はまだ標準化されておらず、患者個人が保有しているパーソナルヘルスレコード（PHR）やウェラブルデバイスのデータを電子カルテに取り込むことは容易ではなく、さらにそれらを統合した医療デジタルツインを活用した医療支援ソリューション開発の具体的事例はみられない。
    【本研究開発提案によって実現するイノベーションと社会貢献】
    本研究開発提案は医療デジタルツインの確立を目指し、そのために疾患特異的診療情報とPHRやウェラブルデバイスのデータを統合する臨床情報プラットフォームを構築する。医療デジタルツインの分析により新しい医学知識を得て、それを基に医療者、医学研究者、医薬品業界、医療機器業界が支援され、さらには患者支援にも応用可能とする。例えば、疾患のリスク推定や予後予測、治療効果予測等、個別性・即時性の高い情報を提供することが可能となり、これに基づき臨床的決定を支援するプログラムの開発を行う。
    これらのイノベーションは、複雑な医療システムに存在する情報共有を妨げる多数の障害を個別に解決することによってのみ達成される。本研究提案では、循環器疾患とがんを対象疾患とし、SS-MIX2と研究開発責任者らの研究グループによる既存のデータベースを基盤として、電子カルテと関連する診療部門システムおよびPHRの標準形式データを結合する臨床情報プラットフォームを構築し、それらから得られた患者情報の集合である医療デジタルツインにおいて発見された医学知識を社会還元するソリューション開発を実証する。研究期間中にテーマD-1で整備されるFHIR基盤に対応し、診療部門システムデータのFHIR化を行い、FHIR基盤上の医療デジタルツインデータの利活用も実証する。

  • A-1 臨床情報プラットフォーム構築による知識発見拠点形成 本研究開発提案は医療デジタルツインの確立を目指し、そのために疾患特異的診療情報とPHRやウェラブルデバイスのデータを統合する臨床情報プラットフォームを構築する。医療デジタルツインの分析により新しい医学知識を得て、それを基に医療者、医学研究者、医薬品業界、医療機器業界が支援され、さらには患者支援にも応用可能とする。例えば、疾患のリスク推定や予後予測、治療効果予測等、個別性・即時性の高い情報を提供することが可能となり、これに基づき臨床的決定を支援するプログラムの開発を行う。

    2023 - 2027

    戦略的イノベーション創造プログラム（SIP）

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    Authorship：Principal investigator  Grant type：Contract research

  • 循環器救急疾患に対する救急医療現場の連携推進のための課題抽出と専門医間の連携構築を目指したガイドブックの作成（２２ＦＡ１６０１）

    2022.4 - 2024.3

    厚生労働科学研究費補助金 

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    Authorship：Coinvestigator(s) 

    "【1年目】
    １．救急医療従事者から見た連携遅延の実態調査行うために、以下5項目の全国アンケート調査を行い改善点の提言を行う。また、総務省消防庁による全国救急搬送データと急性期医療機関情報の連結に関する検討も行う
    ①全国消防本部・日本救急救命学会：プレホスピタル12誘導心電図、病院前主幹動脈閉塞脳卒中スケールの使用率調査
    ②救急医学会：患者受け入れ根拠のQIの抽出、専門医への連携方法の調査
    ③日本循環器学会：12誘導心電図伝送の有無と伝送手段の調査
    ④日本胸部外科学会：大動脈解離のQI使用の有無と画像伝送の有無　
    ⑤日本脳卒中学会：病院前主幹動脈閉塞脳卒中スケールの実施状況と画像伝送の有無
    ２．病院前システム遅延の原因抽出：大阪府MC協議会を介した調査と、大阪府、広島県、岐阜県、茨城県、福岡県の公開データ、J-ASPECT 研究データを用いて、主幹動脈閉塞脳卒中スケール使用の有無による脳卒中患者のプロセス指標、アウトカム指標の比較を以下の項目で行う
    ①プレホスピタル12誘導心電図の使用率の調査
    ②急性解離診療のQIを用いた専門病院選定率の調査
    ③各府県データ、J-ASPECT 研究を用いて、主幹動脈閉塞脳卒中スケールを導入している医療圏における病院前プロセス指標、急性期再開通療法の実施割合、院内プロセス指標と院内死亡、機能的自立の割合を非導入の医療圏と比較する
    ３．初期対応診療医・救急医と専門医の連携の現状把握のために文献のシステマティックレビューを行う
    ①専門医以外の医療従事者の12誘導心電図判読能力
    ②循環器専門医の勤務日と非勤務日に搬送されたST上昇型急性心筋梗塞の診療QI達成率
    ③大動脈解離の診療のQI充足率
    ④脳卒中センター以外の脳卒中応需施設の構造指標と脳卒中患者転送状況に関する現状把握と課題の抽出を行う
    【2年目】
    ・循環器救急疾患に対する救急医療現場と専門医による治療の連携推進のためのガイドブックを作成する
    ・ガイドブックを日本循環器学会、日本救急医学会、日本臨床救急医学会、日本集中治療医学会、日本救急救命学会、日本脳卒中学会のホームページで公開し、メディカルコントロール協議会に周知する
    ・日本蘇生協議会蘇生ガイドライン2025や、救急蘇生法の指針2025にガイドブックの内容を反映させ、最終的には各地域のMC協議会のプロトコルに記載されるように提案する"

  • リアルワールド電子カルテ情報を用いた循環器病の再発・重症化・合併症のリスク因子の分析と介入の費用対効果

    2022.4 - 2024.3

    厚生労働科学研究費補助金 

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    Authorship：Coinvestigator(s) 

    "1．重症虚血性心疾患の多目的データプラットフォームの構築（CLIDAS）
    CLIDASの主要システムの骨格は、7施設においてほぼ完成した。すなわち全データに対して臨床項目による問い合わせ(クエリー)を行い、該当情報を抽出して分析するアプリケーション(CLIDAS-DMS)を、上記7施設に実装した。令和4年度はCLIDASのデータを用いて、虚血性疾患の2次予防（再発・重症化・合併症防止）において、年齢、性、体重、高血圧、脂質異常症、喫煙などの基礎データや、心機能・冠動脈治療部位・血管径・使用デバイスとイベント発生率との関連を明らかにする。
    研究体制は、研究代表者と自治医科大学のスタッフ（興梠、藤田、甲谷）が全体を統括する。臨床クエスチョンの設定は全研究者で行い、データの収集とクレンジング、解析は、2名の女性研究を含む各施設の若手研究者が担当する。またプレシジョン社（代表：佐藤寿彦）に委託してシステムの改善を進める。
    2.自治体のレセプトデータを用いた薬物療法と血管内治療の費用対効果分析
    薬剤（スタチン、心不全薬（β遮断薬、レニン-アンジオテンシン系阻害薬、トルバプタン、イバブラジン、SGLT2阻害薬）等）や血管内治療デバイス使用症例の重症化、再発作、合併症（心不全と脳卒中）の予防効果（千人年あたり）を明らかにしたのち、これまで蓄積してきた熊本県と栃木県の合計約200万人の時系列レセプトデータを用いて、イベント発症防止の費用対効果を分析する。具体的にはCLIDASを用いて効果の推定を行い、この効果検証と同様の背景を持った対象者に対して退院後アウトカム発生までの医療費を集計することで費用を推定する。この際、治療内容だけでなく、検査値・処方内容を含めた背景因子による層別化分析も行う。この部分の研究は、内閣府ImPACT研究の成果を活用し、7年にわたってデータを維持してきた自治医科大学データサイエンスセンターの笹渕が担当する。
    "

  • リアルワールド電子カルテ情報を用いた循環器病の再発・重症化・合併症のリ スク因子の分析と介入の費用対効果

    Grant number：22FA1016  2022 - 2023

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship：Coinvestigator(s)  Grant type：Competitive funding other than Grants-in-Aid for Scientific Research

  • 循環器救急疾患に対する救急医療現場の連携推進のための課題抽出と専門医間の連携構築を目指したガイドブックの作成（２２ＦＡ１６０１）

    Grant number：22674927  2022 - 2023

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship：Coinvestigator(s)  Grant type：Competitive funding other than Grants-in-Aid for Scientific Research

  • 心血管の炎症における酸化ステロールの分子生物学的役割と治療標的の解明

    2021.4 - 2024.3

    科学研究費助成事業 

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    Authorship：Principal investigator 

  • 心血管の炎症における酸化ステロールの分子生物学的役割と治療標的の解明

    Grant number：21H02916  2021 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 標準化クリニカルパスに基づく、医師行動識別センサや問診AIなどのICTを用いた医師の業務負担軽減手法に関する研究

    Grant number：21446701  2021 - 2023

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship：Coinvestigator(s)  Grant type：Competitive funding other than Grants-in-Aid for Scientific Research

  • クリニカルパスデータの標準化・利活用に係る研究

    2018.10 - 2021.3

    医療研究開発推進事業費補助金（日本） 

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    Authorship：Coinvestigator(s) 

    本事業は、日本クリニカルパス学会と日本医療情報学会の合同委員会が主催し、コンセプトは既に広く普及しているもののシステムや運用が標準化されていないクリニカルパス（以下パス）の医療施設・ベンダー間の標準化や相互運用性を進め、複数医療施設に集積したパスデータの統合解析を次世代医療基盤法上で可能とすることを目的とする。まず、収集するデータの解析を志向し、またパス移植性など相互運用性も考慮したパス標準データリポジトリ（以下リポジトリ）規格を定める。リポジトリ規格には、アウトカム・アセスメント（観察項目）・タスクの三層データ構造によるアウトカムユニットを医療工程の最小単位として用い、そのマスターにはHELICS標準化の最終段階である標準アウトカムマスター（以下BOM）の使用を前提とする。次に、実証ターゲットをパスシステムのトップ4ベンダーおよび導入4医療施設とする。リポジトリ規格のデータ構造へデータ出力する標準アウトカム志向型パスシステム（以下標準パスシステム）を各医療施設に導入し、リポジトリおよびその間のインタフェイス（以下IF）を構築する。さらに、複数医療施設から出力されるパスデータの解析基盤を構築する。8種以上の実証用標準的パスを実証医療施設や研究分担者、協力臨床学会等の専門医により策定し、標準パスシステムへ格納し、倫理審査や各医療施設のオーソライズを経て、実入院患者を用いた標準パスシステム実証研究を約1年間行う。蓄積したパスデータをベンチマーク、統合解析するとともに、認定機関により匿名加工情報化しても同様の解析ができることを確認する。実証研究を経て抽出された課題への対策を検討し、標準パスシステム、IF、リポジトリ規格、解析基盤の改修を行う。8種以上の実証用標準的パスも、解析を経て改訂し学会主導の標準パスとする。タスクを含むBOMの改訂、リポジトリ規格のJAHIS標準化を行い、後者はHELICS標準へも申請する。本事業によりベンダー間でパスシステムの標準化が進み、その出力形式やパス移植などの相互運用性が確保されることから、多くの他のパス内容も標準化されるのみならず、パス解析基盤が次世代医療基盤上に構築され、パス活動が活性化と医療の質や効率が劇的に向上することが期待される。アウトカムユニットを中心とした工程管理は次世代電子カルテの技術要素として期待される。

  • 分化再生と生体恒常性を制御するエクソソームの新しい細胞同調機能の解明とナノ粒子による生体機能制御への応用

    2017.10 - 2023.3

    国立研究開発法人　科学技術振興機構（日本） 

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    Authorship：Coinvestigator(s) 

    分化再生と生体恒常性を制御するエクソソームの新しい細胞同調機能の解明とナノ粒子による生体機能制御への応用

  • 分化再生と生体恒常性を制御するエクソソームの新しい細胞同調機能の解 明とナノ粒子による生体機能制御への応用

    2017 - 2022

    日本学術振興会  戦略的創造研究推進事業・CREST

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    Authorship：Coinvestigator(s)  Grant type：Joint research

  • 研究項目：SS-MIX2データ抽出システム実装とテストおよびアウトカムテンプレート仕様検討

    Grant number：H28-ICT-一般-006  2017 - 2019

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship：Coinvestigator(s)  Grant type：Competitive funding other than Grants-in-Aid for Scientific Research

  • JROAD・J-ASPECT・脳卒中データバンクによる全国規模レジストリーによる脳卒中および循環器疾 患の実態把握の確立と両疾患合併例に関する包括的診療実態解明

    Grant number：18ek0210089h0002  2017 - 2019

    科学研究費助成事業  AMED: JROAD・J-ASPECT・脳卒中データバンクによる全国規模レジストリーによる脳卒中および循環器疾 患の実態把握の確立と両疾患合併例に関する包括的診療実態解明

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    Authorship：Coinvestigator(s)  Grant type：Competitive funding other than Grants-in-Aid for Scientific Research

  • 急性心筋梗塞後の心臓修復を促進する革新的PPARγナノ医薬の研究開発

    Grant number：17K09590  2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 重症肺高血圧症の予後と生活の質を改善するための安心安全のナノ医療製剤(希 少疾病用医薬品)の実用化臨床試験

    Grant number：H24-難治等(難)-一般-009  2014

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship：Coinvestigator(s)  Grant type：Competitive funding other than Grants-in-Aid for Scientific Research

  • ナノ医薬学融合に基づくPPARγナノ医薬による難治性心血管病の革新的治療法の開発

    Grant number：25461135  2013 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 単球Ｍ１／Ｍ２分化制御による大動脈瘤進展・破裂に対する新しいナノ治療法の研究開発

    Grant number：23790861  2011 - 2012

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • マクロファージ分化スイッチ制御による粥状動脈硬化プラーク破綻予防療法の研究開発

    Grant number：21790734  2009 - 2010

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • New therapeutic approach to control atherosclerotic cardiovascular disease

    2008 - 2009

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    Authorship：Principal investigator  Grant type：Contract research

  • 動脈硬化プラーク破綻におけるマクロファージ・アポトーシスの役割解明と治療法

    Grant number：19790532  2007 - 2008

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

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Educational Activities

  • Education for medical students: Bedside teaching for grade 5, Clinical clerkship for grade 6
    Education for graduate students: Basic and clinical research on cardiology and vascular biology
    Education for medical staff in the university hospital on resuscitation and cardiovascular care

Class subject

  • 医学部3学年「循環器」講義

    2023.10 - 2024.3   Second semester

  • 保健学科・循環機能検査学

    2023.4 - 2023.9   First semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2023.4 - 2023.9   First semester

  • 薬学部早期体験学習（一次救命）

    2022.10 - 2023.3   Second semester

  • 医学部3学年「循環器」講義

    2022.10 - 2023.3   Second semester

  • 循環機能検査学

    2022.4 - 2022.9   First semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2022.4 - 2022.9   First semester

  • 医学部3学年「循環器」講義

    2021.10 - 2022.3   Second semester

  • 薬学部早期体験学習（一次救命）

    2021.10 - 2022.3   Second semester

  • 医学部3学年「循環器」講義

    2021.10 - 2022.3   Second semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2021.4 - 2021.9   First semester

  • 循環機能検査学

    2021.4 - 2021.9   First semester

  • 医学部3学年「循環器」講義

    2020.10 - 2021.3   Second semester

  • 薬学部早期体験学習（一次救命）

    2020.10 - 2021.3   Second semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2020.4 - 2020.9   First semester

  • 医学部3学年「循環器」講義

    2019.10 - 2020.3   Second semester

  • 薬学部早期体験学習（一次救命）

    2019.10 - 2020.3   Second semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2019.4 - 2019.9   First semester

  • 医学部3学年「循環器」講義

    2018.10 - 2019.3   Second semester

  • 薬学部早期体験学習（一次救命）

    2018.10 - 2019.3   Second semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2018.4 - 2018.9   First semester

  • 医学部3学年「循環器」講義

    2017.10 - 2018.3   Second semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2017.4 - 2017.9   First semester

  • 医学部3学年「循環器」講義

    2016.10 - 2017.3   Second semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2016.4 - 2016.9   First semester

  • 医学部3学年「循環器」講義

    2015.10 - 2016.3   Second semester

  • 病態制御学

    2015.4 - 2015.9   First semester

  • 医歯薬合同講義 循環器・呼吸器・造血器概論 循環器概論（１単位）

    2015.4 - 2015.9   First semester

  • 医学部3学年「循環器」講義

    2014.10 - 2015.3   Second semester

  • 病態制御学

    2014.4 - 2014.9   First semester

  • 医学部3学年「循環器」講義

    2013.10 - 2014.3   Second semester

  • 病態制御学

    2013.4 - 2013.9   First semester

  • 医学部3学年「循環器」講義

    2012.10 - 2013.3   Second semester

  • 心臓弁膜症

    2011.10 - 2012.3   Second semester

  • 心臓カテーテル検査・治療

    2011.4 - 2011.9   First semester

  • 保健学科検査先攻3年生 心臓カテーテル検査・治療

    2010.4 - 2010.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • Certified Instructor for American Heart Association BLS and ACLS Provider Course

Social Activities

  • 身近に潜む心臓病

    第87回　日本循環器学会学術集会・市民公開講座  福岡サンパレス  2023.3

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

  • 身近に潜む心臓病

    日本循環器学会学術集会  2023.3

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

  • 市民公開講座「動脈硬化性脳心血管病の危険なサインを見逃さない～いのちを守るために知っておきたいこと～」

    日本動脈硬化学会  福岡  2018.2

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

  • 第３回 患者さんとご家族のための心肺蘇生法 実習コース

    主催：九州大学病院ハートセンター・循環器内科 後援：日本循環器学会  九州大学病院  2015.3

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

    心臓疾患患者とその家族のための心肺蘇生法実習を公開して開催している。

  • 第２回 患者さんとご家族のための心肺蘇生法 実習コース

    主催：九州大学病院ハートセンター・循環器内科 後援：日本循環器学会  九州大学病院  2014.10

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

  • 日本循環器学会における米国心臓協会心肺蘇生トレーニングセンター（JCS-ITC）BLSファカルティ、およびACLSインストラクターとして、医療従事者および一般市民に対する心肺蘇生法教育に携わっている。

    2014

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    日本循環器学会における米国心臓協会心肺蘇生トレーニングセンター（JCS-ITC）BLSファカルティ、およびACLSインストラクターとして、医療従事者および一般市民に対する心肺蘇生法教育に携わっている。

  • 米国心臓協会（AHA）のBLSファカルティ・インストラクターとして、BLSヘルスケアプロバイダーコースを主宰した。

    主宰は米国心臓協会（AHA）、開催施設として九州大学病院、佐賀大学病院、九州厚生年金病院と連携した。  九州大学病院クリニカルスキルトレーニングセンター、佐賀大学病院、九州厚生年金病院  2013.3

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • 市民公開講座「動脈硬化が原因で起こる 心臓・血管の病気」

    九州大学高度先端医療センター  イムズホール  2012.2

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

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Travel Abroad

  • 2003.9 - 2006.3

    Staying countory name 1：United States   Staying institution name 1：Cardiovascular Research Institute, University of Rochester Medical Center

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Cardiology

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Metabolism

    動脈硬化

Clinician qualification

  • Certifying physician

    日本心血管インターベンション学会

  • Specialist

    The Japanese Society of Internal Medicine（JSIM）

  • Specialist

    The Japanese Circulation Society（JCS）

  • Specialist

    日本動脈硬化学会

Year of medical license acquisition

  • 1996

Notable Clinical Activities

  • 病院臨床試験倫理審査委員会委員 ARO専門委員会委員 心肺蘇生サポート委員会委員