ONOYAMA ICHIRO
Organization
Kyushu University Hospital Gynecology & Obstetrics Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Contact information
Tel
0926425394
Profile
I am engaged in seeing out-patients and gynecologic operation as an OB/GY doctor everyday.
My research field is epigenetics in cancer. I also take charge of ward training of medical-school students.
Homepage
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http://www.med.kyushu-u.ac.jp/gynob/index.html
Department of Obstetrics and Gynecology, Kyushu University Medical Science
External link
Degree
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Ph-D in Medicine
Research Interests・Research Keywords
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Research theme：A study about genome-wide hypomethylation in cancer cells
Keyword：Genome-wide DNA hypomethylation
Research period： 2016.4 - 2026.3
Papers
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Loss of Fbxw7 Impairs Development of and Induces Heterogeneous Tumor Formation in the Mouse Mammary Gland Reviewed International journal
Ichiro Onoyama, Shogo Nakayama, Hideyuki Shimizu, Keiichi I Nakayama
Cancer Research 2020.12
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Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia Reviewed International journal
Masaya Kato, Ichiro Onoyama, Minoru Kawakami, Sachiko Yoshida, Keiko Kawamura, Keisuke Kodama, Emiko Hori, Lin Cui, Yumiko Matsumura, Hiroshi Yagi, Kazuo Asanoma, Hideaki Yahata, Atsuo Itakura, Satoru Takeda, Kiyoko Kato
PLoS One 2020.11
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Ipsilateral Right Angular Pregnancy After a Laparoscopic Right Salpingo-Oophorectomy: A Case Report Invited Reviewed International journal
To G, Kodama K, Onoyama I, Yahata H, Kato K.
Cureus 2024.5
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Development of novel tracers for sentinel node identification in cervical cancer. Invited Reviewed International journal
Kodama K, Tateishi C, Oda T, Cui L, Kuramoto K, Yahata H, Okugawa K, Maenohara S, Yagi H, Yasunaga M, Onoyama I, Asanoma K, Mori T, Katayama Y, Kato K.
Cancer Sci. 2023.11
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Decision-making for Subsequent Therapy for Patients With Recurrent or Advanced Endometrial Cancer Based on the Platinum-free Interval Reviewed International journal
Yasunaga M, Yahata H, Okugawa K, Hori E, Hachisuga K, Maenohara S, Kodama K, Yagi H, Ohgami T, Onoyama I, Asanoma K, Kato K.
American Journal of Clinical Oncology 2023.6
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Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer. Reviewed International journal
2022.10
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Evaluation of Clinical Significance of Lymphovascular Space Invasion in Stage IA Endometrial Cancer Invited Reviewed International journal
Okugawa, Kaoru; Yahata, Hideaki; Hachisuga, Kazuhisa; Tomonobe, Hiroshi; Yasutake, Nobuko; Kodama, Keisuke; Kenjo, Hironori; Yagi, Hiroshi; Ohgami, Tatsuhiro; Yasunaga, Masafumi; Onoyama, Ichiro; Asanoma, Kazuo; Hori, Emiko; Ohishi, Yoshihiro; Oda, Yoshinao; Kato, Kiyoko
ONCOLOGY 100 ( 4 ) 195 - 202 2022.4
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Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer Invited Reviewed International journal
Hideaki Yahata, Keisuke Kodama, Kaoru Okugawa, Kazuhisa Hachisuga, Nobuko Yasutake, Shoji Maenohara, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Kazuo Asanoma, Hiroaki Kobayashi, Kenzo Sonoda, Shingo Baba, Kousei Ishigami, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato
Gynecol Oncol 2022.2
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Prognostic impact of the subclassification of Müllerian cancer stage IV in the FIGO 2014 staging system with a focus of extra-abdominal lymph node metastases. Invited Reviewed International journal
2021.7
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YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer Invited Reviewed International journal
Suzuki, Izumi; Yoshida, Sachiko; Tabu, Kouichi; Kusunoki, Soshi; Matsumura, Yumiko; Izumi, Hiroto; Asanoma, Kazuo; Yagi, Hiroshi; Onoyama, Ichiro; Sonoda, Kenzo; Kohno, Kimitoshi; Taga, Tetsuya; Itakura, Atsuo; Takeda, Satoru; Kato, Kiyoko
SCIENTIFIC REPORTS 11 ( 1 ) 2021.2
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Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells Invited Reviewed International journal
Yoshida, Sachiko; Asanoma, Kazuo; Yagi, Hiroshi; Onoyama, Ichiro; Hori, Emiko; Matsumura, Yumiko; Okugawa, Kaoru; Yahata, Hideaki; Kato, Kiyoko
BMC CANCER 21 ( 1 ) 2021.2
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Identification of genes associated with endometrial cell ageing Invited Reviewed International journal
Kawamura, Teruhiko; Tomari, Hiroyuki; Onoyama, Ichiro; Araki, Hiromitsu; Yasunaga, Masafumi; Lin, Cui; Kawamura, Keiko; Yokota, Natsuko; Yoshida, Sachiko; Yagi, Hiroshi; Asanoma, Kazuo; Sonoda, Kenzo; Egashira, Katsuko; Ito, Takashi; Kato, Kiyoko
MOLECULAR HUMAN REPRODUCTION 27 ( 2 ) 2021.2
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Evaluation of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer: a single-institution experience. Invited Reviewed International journal
Okugawa K, Yahata H, Sonoda K, Kodama K, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Kaneki E, Asanoma K, Kobayashi H, Kato K.
Int J Clin Oncol 2020.9
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Nonlinear Optics with Near-Infrared Excitation Enable Real-Time Quantitative Diagnosis of Human Cervical Cancers. Invited Reviewed International journal
Matsui T, Tamoto R, Iwasa A, Mimura M, Taniguchi S, Hasegawa T, Sudo T, Mizuno H, Kikuta J, Onoyama I, Okugawa K, Shiomi M, Matsuzaki S, Morii E, Kimura T, Kato K, Kiyota Y, Ishii M.
Cancer Res 2020.9
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Is Adjuvant Therapy Necessary for Patients with Intermediate-Risk Cervical Cancer after Open Radical Hysterectomy? Invited Reviewed International journal
Yahata H, Sonoda K, Inoue S, Yasutake N, Kodama K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Asanoma K, Kato K.
Oncology 2020.7
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Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10-year experience of a single institute. Reviewed International journal
Kodama K, Sonoda K, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Yahata H, Ohishi Y, Oda Y, Kato K.
Asia Pac J Clin Oncol. 2020.4
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Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer. Reviewed International journal
Kato M, Onoyama I, Yoshida S, Cui L, Kawamura K, Kodama K, Hori E, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K
Int J Cancer. 2020.3
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Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer. Reviewed International journal
2019.12
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Survey of the desire to have children and engage in sexual activity after trachelectomy among young Japanese women with early-stage cervical cancer. Reviewed International journal
Yahata H, Sonoda K, Okugawa K, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Kaneki E, Asanoma K, Kato K.
J Obstet Gynaecol Res. 2019.11
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Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells. Reviewed International journal
Asanoma K, Hori E, Yoshida S, Yagi H, Onoyama I, Kodama K, Yasunaga M, Ohgami T, Kaneki E, Okugawa K, Yahata H, Kato K
Oncotarget 2019.7
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Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer. Reviewed International journal
Yahata H, Kobayashi H, Sonoda K, Kodama K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Baba S, Isoda T, Ohishi Y, Oda Y, Kato K
Int J Clin Oncol. 2018.12
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Two types of small cell carcinoma of the ovary: Two typical case reports. Reviewed International journal
Yoshida Y, Kaneki E, Kijima M, Kodama K, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Okugawa K, Yahata H, Sonoda K, Kato K.
Gynecol Oncol Rep 2018.7
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Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway Reviewed International journal
2018.3
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FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors Reviewed International journal
Ichiro Onoyama
Cancer Science in press 2016.8
Books
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子宮肉腫研究の最前線
小野山一郎、加藤聖子（ Role： Joint author）
2023.3
Presentations
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Initial epigenetic alteration induced by aberrant activation of RAS-MAPK signaling in non-transformed cells
Ichiro, Yagi Hiroshi, Asanoma Kazuo, Kawakami Minoru, Hachisuga Kazuhisa, Tomonobe Hiroshi, Maenohara Shoji, Kodama Keisuke, Yasunaga Masafumi, Yahata Hideaki, Kato Kiyoko
2024.4
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The incidence of gastrointestinal perforation in cervical cancer patients who received radiotherapy and bevacizumab-containing chemotherapy: a single institutional survey.
2023.7
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Epigenetic characterization of ovarian high-grade serous carcinoma by genome-wide 5-hydroxymethylcytosine sequencing
Ichiro Onoyama, Masaya Kato, Minoru Kawakami, Kazuhisa Hachisuga, Shoji Maenohara, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Kazuo Asanoma, Hideaki Yahata, Kiyoko Kato
2023.6
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子宮体癌に対するペンブロリズマブ治療中にACTH欠損症を起こした2例
小野山一郎， 川上穣， 蜂須賀一寿， 前之原章司， 小玉敬亮， 八木裕史， 安永昌史， 大神 達寛， 奥川馨， 淺野間和夫， 矢幡秀昭， 北村雄哉， 坂本竜一， 加藤聖子
第64回日本婦人科腫瘍学会学術講演会 2022.7
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Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia
2021.10
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FRZB is induced by RAS-MAPK signaling and counteracts transformation.
Ichiro Onoyama, Kato Masaya, Keisuke Kodama, Hiroshi Yagi, Kazuo Asanoma, Kenzo Sonoda, Kiyoko Kato
2018.9
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FRZB is induced by RAS-MAPK signaling and couteract transformation
Ichiro Onoyama, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Kazuo Asanoma, Kenzo Sonoda, Kiyoko Kato
2018.5
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Oncogenic BRAF promotes global DNA hypomethylation via upregulation of DNA demethylase TET3 level International conference
Ichiro Onoyama, Kenzo Sonoda, Michael R Green, Kiyoko Kato
The 5th Biennial Meeting of Asian Society of Gynecologic Oncology 2017.12
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外陰Paget病の擦過細胞診に関する後方視的検討
小野山 一郎、園田 顕三、奥川 馨、兼城 英輔、安永 昌史、大神 達寛、山口 真一郎、小玉 敬亮、加来 恒壽、加藤 聖子
日本臨床細胞学会 2017.11
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Oncogenic BRAF promotes global DNA hypomethylation via upregulation of DNA demethylase TET3 level
2016.10
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BRAF、KRAS変異はTET3を介してゲノムワイドなDNA脱メチル化を促進する Invited
小野山 一郎, 園田 顕三, 加藤 聖子
日本サイトメトリー学会 2016.7
MISC
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子宮肉腫研究の最前線
小野山一郎, 加藤聖子
産科と婦人科 2023.3
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子宮内膜がんに対する分子標的薬
小野山 一郎, 加藤 聖子
2016.8
Professional Memberships
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Japan Society of Obstetrics and Gynecology
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日本癌学会
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日本臨床細胞学会
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日本婦人科腫瘍学会
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日本癌治療学会
Academic Activities
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Reports International contribution
2023.5 - 2026.5
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Screening of academic papers
Role(s)： Peer review
2023
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司会（Moderator）
生殖医学フォーラム （ 石川県加賀市 ） 2017.6
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Screening of academic papers
Role(s)： Peer review
2016
Research Projects
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卵巣癌におけるゲノムワイドな5hmC解析と臨床病理学的因子に関する研究
Grant number：2 3 K 0 8 8 0 0 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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卵巣癌におけるゲノムワイドな5hmC解析と臨床病理学的因子に関する研究
Grant number：23K08800 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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卵巣漿液性癌におけるDNA脱メチル化産物5hmCと転移に関する研究
2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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卵巣漿液性癌におけるDNA脱メチル化産物5hmCと転移に関する研究
Grant number：20K09646 2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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DNA脱メチル化酵素TET3の発癌、腫瘍進展における生理学的役割の解明
2016 - 2018
平成28年度臨床研究助成
Authorship：Principal investigator Grant type：Contract research
Educational Activities
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I teach biological experiments to post-graduate students.
Class subject
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婦人科がん
2023.10 - 2024.3 Second semester
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外陰疾患
2023.10 - 2024.3 Second semester
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外陰疾患
2022.10 - 2023.3 Second semester
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婦人科がん
2022.10 - 2023.3 Second semester
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婦人科がん
2021.10 - 2022.3 Second semester
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外陰疾患
2021.10 - 2022.3 Second semester
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外陰疾患
2020.10 - 2021.3 Second semester
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婦人科がん
2020.10 - 2021.3 Second semester
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婦人科がん
2019.10 - 2020.3 Second semester
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婦人科がん
2018.10 - 2019.3 Second semester
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産婦人科クリニカルクラークシップ
2018.4 - 2018.9 First semester
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婦人科がん
2017.10 - 2018.3 Second semester
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各種がんの治療
2016.10 - 2017.3 Second semester
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臨床実習Ⅰ
2016.10 - 2017.3 Second semester
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臨床実習Ⅰ
2016.4 - 2016.9 First semester
Participation in international educational events, etc.
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2024.3
TG-MET Center
International workshop 2024
Venue：タイ・バンコク
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2019.3
九州大学病院国際医療部
平成３０年度九州大学病院椎木基金支援助成事業短期海外研修プログラム
Venue：フィリピン、マカティ
Number of participants：9
Outline of Social Contribution and International Cooperation activities
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I contribute to community medicine with cancer screening and prenatal care.
I support ward training of foreign students in OB/GY department.
Travel Abroad
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2016.3
Staying countory name 1：United States Staying institution name 1：University of Massachusetts Medical School
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Obstetrics and Gynecology
Clinician qualification
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Certifying physician
Japan Society of Obstetrics and Gynecology（JSOG）
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Certifying physician
日本がん治療認定医機構
Year of medical license acquisition
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1999
Notable Clinical Activities
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九州大学病院産婦人科における婦人科悪性腫瘍研究機構（JGOG）の担当として、臨床試験に関わっている。 副病棟医長として、婦人科の外来、手術全般に関するマネージメントを行っている。