Updated on 2024/12/04

Information

 

写真a

 
ONOYAMA ICHIRO
 
Organization
Kyushu University Hospital Gynecology & Obstetrics Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425394
Profile
I am engaged in seeing out-patients and gynecologic operation as an OB/GY doctor everyday. My research field is epigenetics in cancer. I also take charge of ward training of medical-school students.
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Degree

  • Ph-D in Medicine

Research Interests・Research Keywords

  • Research theme:A study about genome-wide hypomethylation in cancer cells

    Keyword:Genome-wide DNA hypomethylation

    Research period: 2016.4 - 2026.3

Papers

  • Loss of Fbxw7 Impairs Development of and Induces Heterogeneous Tumor Formation in the Mouse Mammary Gland Reviewed International journal

    Ichiro Onoyama, Shogo Nakayama, Hideyuki Shimizu, Keiichi I Nakayama

    Cancer Research   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia Reviewed International journal

    Masaya Kato, Ichiro Onoyama, Minoru Kawakami, Sachiko Yoshida, Keiko Kawamura, Keisuke Kodama, Emiko Hori, Lin Cui, Yumiko Matsumura, Hiroshi Yagi, Kazuo Asanoma, Hideaki Yahata, Atsuo Itakura, Satoru Takeda, Kiyoko Kato

    PLoS One   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Clinical Significance of Tumor Immune Microenvironment in Endometrial Endometrioid Carcinoma, Grade 1 With DNA Mismatch Repair Protein Loss

    Hachisuga, K; Kawakami, M; Tomonobe, H; Maenohara, S; Kodama, K; Yagi, H; Yasunaga, M; Onoyama, I; Asanoma, K; Yahata, H; Oda, Y; Kato, K

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY   43 ( 6 )   573 - 585   2024.11   ISSN:0277-1691 eISSN:1538-7151

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    Publisher:International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists  

    The administration of immune checkpoint inhibitors (ICIs) is increasing in endometrial cancer, especially in the mismatch repair (MMR)-deficient group. To prevent unnecessary immune-related adverse events, ICIs need to be administered to more appropriate patients. The tumor immune microenvironment has been reported to be a predictive marker of the efficacy of ICI therapies. This study evaluated CD8, FoxP3, CD68, PD-L1, and β-catenin expression in endometrial endometrioid carcinoma, grade 1 (G1) with DNA mismatch repair protein loss (MMR loss), and their association with clinicopathological features. We retrospectively analyzed tumor samples from 107 patients with endometrial endometrioid carcinoma, G1 (MMR-deficient group: n=67; MMR-proficient group: n=40). Overall, 47 cases of MLH1/PMS2 loss and 20 cases of MSH2/MSH6 loss were observed. The patients with low intraepithelial CD8 expression significantly more frequently exhibited deep myometrial invasion, and the elderly group (≥60 y) significantly more frequently showed low stromal CD8 expression. In addition, FoxP3-positive cell count and FoxP3/CD8+ ratio were significantly correlated with the International Federation of Obstetrics and Gynecology 2023 stage and lymph node metastasis. In the Kaplan-Meier analysis, the patients with low intraepithelial or stromal CD8 expression had shorter progression-free survival (PFS) than those with high intraepithelial or stromal CD8 expression, albeit not significantly. We clarified that the tumor immune microenvironment had an impact on clinicopathological features within the group with MMR loss, which is the main target for ICIs, limited to endometrioid carcinoma, G1. Further studies are needed, including on patients administered ICIs.

    DOI: 10.1097/PGP.0000000000001020

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  • Clear Cell Carcinoma Arising From Adenomyotic Cyst: A Case Report.

    Morishita Y, Yagi H, Onoyama I, Yahata H, Kato K

    Cureus   16 ( 10 )   e71503   2024.10   ISSN:2168-8184

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    Language:English  

    DOI: 10.7759/cureus.71503

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  • Endometrial senescence is mediated by interleukin 17 receptor B signaling (vol 22, 363, 2024)

    Kawamura, K; Matsumura, Y; Kawamura, T; Araki, H; Hamada, N; Kuramoto, K; Yagi, H; Onoyama, I; Asanoma, K; Kato, K

    CELL COMMUNICATION AND SIGNALING   22 ( 1 )   370   2024.7   eISSN:1478-811X

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    Language:English   Publisher:Cell Communication and Signaling  

    Correction: Cell Commun Signal 22, 363 (2024). https://doi.org/10.1186/s12964-024-01740-5. Following publication of the original article [1], the authors reported that the incorrect additional file 12 was published. The correct additional file is published in this correction article and the original article [1] has been corrected.

    DOI: 10.1186/s12964-024-01754-z

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  • Endometrial senescence is mediated by interleukin 17 receptor B signaling

    Kawamura, K; Matsumura, Y; Kawamura, T; Araki, H; Hamada, N; Kuramoto, K; Yagi, H; Onoyama, I; Asanoma, K; Kato, K

    CELL COMMUNICATION AND SIGNALING   22 ( 1 )   363   2024.7   eISSN:1478-811X

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    Language:English   Publisher:Cell Communication and Signaling  

    Background: We previously identified Il17RB, a member of the IL17 superfamily, as a candidate marker gene for endometrial aging. While IL17RB has been linked to inflammation and malignancies in several organ systems, its function in the endometrium has not been investigated and is thus poorly understood. In the present study, we performed a functional analysis of this receptor with the aim of determining the effects of its age-associated overexpression on the uterine environment. Methods: We analyzed IL17RB-related signaling pathways and downstream gene expression in an immortalized human endometrial glandular epithelial cell line (“hEM”) forced to express the receptor via lentiviral transduction (“IL17RB-hEM”). We also prepared endometrial organoids from human endometrial tissue sourced from hysterectomy patients (“patient-derived EOs”) and exposed them to cytokines that are upregulated by IL17RB expression to investigate changes in organoid-forming capacity and senescence markers. We analyzed RNA-seq data (GEO accession number GSE132886) from our previous study to identify the signaling pathways associated with altered IL17RB expression. We also analyzed the effects of the JNK pathway on organoid-forming capacity. Results: Stimulation with interleukin 17B enhanced the NF-κB pathway in IL17RB-hEM, resulting in significantly elevated expression of the genes encoding the senescence associated secretory phenotype (SASP) factors IL6, IL8, and IL1β. Of these cytokines, IL1β inhibited endometrial organoid growth. Bioinformatics analysis showed that the JNK signaling pathway was associated with age-related variation in IL17RB expression. When IL17RB-positive cells were cultured in the presence of IL17B, their organoid-forming capacity was slightly but non-significantly lower than in unexposed IL17RB-positive cells, but when IL17B was paired with a JNK inhibitor (SP600125), it was restored to control levels. Further, IL1β exposure significantly reduced organoid-forming capacity and increased p21 expression in endometrial organoids relative to non-exposure (control), but when IL1β was paired with SP600125, both indicators were restored to levels comparable to the control condition. Conclusions: We have revealed an association between IL17RB, whose expression increases in the endometrial glandular epithelium with advancing age, and cellular senescence. Using human endometrial organoids as in vitro model, we found that IL1β inhibits cell proliferation and leads to endometrial senescence via the JNK pathway.

    DOI: 10.1186/s12964-024-01740-5

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  • Ipsilateral Right Angular Pregnancy After a Laparoscopic Right Salpingo-Oophorectomy: A Case Report Invited Reviewed International journal

    To G, Kodama K, Onoyama I, Yahata H, Kato K.

    Cureus   2024.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 術前補助化学療法後の巨大再発成人顆粒膜細胞腫に対して完全縮小手術を施行した1例(Complete reduction surgery of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy)

    Tokui Hiroha, Yahata Hideaki, Okabe Yasuhiro, Magarifuchi Naomi, Maenohara Shoji, Hachisuga Kazuhisa, Tomonobe Hiroshi, Kodama Keisuke, Yagi Hiroshi, Yasunaga Masafumi, Onoyama Ichiro, Asanoma Kazuo, Oda Yoshinao, Nakamura Masafumi, Kato Kiyoko

    International Cancer Conference Journal   13 ( 2 )   162 - 166   2024.4

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    Language:English   Publisher:シュプリンガー・ジャパン(株)  

    症例は72歳女性、2妊2産であった。卵巣悪性腫瘍に対して52歳時に開腹子宮全摘術、両側卵管卵巣摘出術、大網切除術、骨盤リンパ節郭清術を施行され、最終診断はステージIaの成人型顆粒膜細胞腫(AGCT)であった。初回手術から19年後、他施設で受けたCTで後腹膜腫瘍が偶然発見された。腫瘍は直径11×10cmで、肝門部、下大静脈、右腎静脈が隆起していた。CTガイド下腫瘍生検によりAGCTの再発が確認された。腫瘍が巨大であり、完全切除を行うと出血多量による術中死亡のリスクがあると考えられた。そこで、パクリタキセル+カルボプラチン(PC)による術前化学療法を行い、再発腫瘍を縮小させた。その後、縮小手術を行った。再発腫瘍の完全切除に成功し、手術時間は12時間54分、出血量は700gであった。切除標本の病理所見からAGCTの再発と診断した。術後1年経過時点で再発は認められなかった。

  • Complete reduction surgery of a huge recurrent adult granulosa cell tumor after neoadjuvant chemotherapy

    Tokui, H; Yahata, H; Okabe, Y; Magarifuchi, N; Maenohara, S; Hachisuga, K; Tomonobe, H; Kodama, K; Yagi, H; Yasunaga, M; Onoyama, I; Asanoma, K; Oda, Y; Nakamura, M; Kato, K

    INTERNATIONAL CANCER CONFERENCE JOURNAL   13 ( 2 )   162 - 166   2024.4   ISSN:2192-3183

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  • The BHLHE40-PPM1F-AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer

    Asanoma, K; Yagi, H; Onoyama, I; Cui, L; Hori, E; Kawakami, M; Maenohara, S; Hachisuga, K; Tomonobe, H; Kodama, K; Yasunaga, M; Ohgami, T; Okugawa, K; Yahata, H; Kitao, H; Kato, K

    JOURNAL OF BIOLOGICAL CHEMISTRY   300 ( 3 )   105695   2024.3   ISSN:00219258 eISSN:1083-351X

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    Language:English   Publisher:Journal of Biological Chemistry  

    BHLHE40 is a basic helix-loop-helix transcription factor that is involved in multiple cell activities including differentiation, cell cycle, and epithelial-to-mesenchymal transition. While there is growing evidence to support the functions of BHLHE40 in energy metabolism, little is known about the mechanism. In this study, we found that BHLHE40 expression was downregulated in cases of endometrial cancer of higher grade and advanced disease. Knockdown of BHLHE40 in endometrial cancer cells resulted in suppressed oxygen consumption and enhanced extracellular acidification. Suppressed pyruvate dehydrogenase (PDH) activity and enhanced lactated dehydrogenase (LDH) activity were observed in the knockdown cells. Knockdown of BHLHE40 also led to dephosphorylation of AMPKα Thr172 and enhanced phosphorylation of pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) Ser293 and lactate dehydrogenase A (LDHA) Tyr10. These results suggested that BHLHE40 modulates PDH and LDH activity by regulating the phosphorylation status of PDHA1 and LDHA. We found that BHLHE40 enhanced AMPKα phosphorylation by directly suppressing the transcription of an AMPKα-specific phosphatase, PPM1F. Our immunohistochemical study showed that the expression of BHLHE40, PPM1F, and phosphorylated AMPKα correlated with the prognosis of endometrial cancer patients. Because AMPK is a central regulator of energy metabolism in cancer cells, targeting the BHLHE40‒PPM1F‒AMPK axis may represent a strategy to control cancer development.

    DOI: 10.1016/j.jbc.2024.105695

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  • Development of novel tracers for sentinel node identification in cervical cancer

    Kodama Keisuke, Tateishi Chuya, Oda Tsuyoshi, Cui Lin, Kuramoto Kazutaka, Yahata Hideaki, Okugawa Kaoru, Maenohara Shoji, Yagi Hiroshi, Yasunaga Masafumi, Onoyama Ichiro, Asanoma Kazuo, Mori Takeshi, Katayama Yoshiki, Kato Kiyoko

    Cancer Science   114 ( 11 )   4216 - 4224   2023.11   ISSN:13479032 eISSN:13497006

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    Indocyanine green (ICG) with near-infrared (NIR) fluorescence imaging is used for lymphatic mapping. However, binding of ICG to blood proteins like serum albumin can shorten its retention time in sentinel lymph nodes (SLNs). Here, we investigated the efficacy and safety of a new fluorescence tracer comprising phytate and liposome (LP)-encapsulated ICG. Coadministration of phytate with LP containing phosphatidic acid promotes chelation mediated by Ca^<2+> in bodily fluids to enhance SLN retention. Uniformly sized LPs (100 nm) encapsulating ICG under conditions that minimized fluorescence self-quenching during storage were produced. We analyzed the behavior of the new tracer (ICG-phytate-LP) and control tracers (ICG and ICG-LP) in the lymphatic flow of mice in terms of lymph node retention time. We also tested lymphatic flow and safety in pigs that have a more human-like lymphatic system. LPs encapsulating stabilized ICG were successfully prepared. Mixing LP with phytate in the presence of Ca^<2+> increased both the particle size and negative surface charge. In mice, ICG-phytate-LP had the best lymph node retention, with a fluorescence intensity ratio that increased over 6 h and then decreased slowly over the next 24 h. In pigs, administration of ICG and ICG-phytate-LP resulted in no death or weight loss. There were no obvious differences between blood test results for the ICG and ICG-phytate-LP groups, and the overall safety was good. ICG-phytate-LP may be a useful new tracer for gynecological cancers that require time for lymph node identification due to a retroperitoneal approach.

    CiNii Research

  • Development of novel tracers for sentinel node identification in cervical cancer. Invited Reviewed International journal

    Kodama K, Tateishi C, Oda T, Cui L, Kuramoto K, Yahata H, Okugawa K, Maenohara S, Yagi H, Yasunaga M, Onoyama I, Asanoma K, Mori T, Katayama Y, Kato K.

    Cancer Sci.   2023.11

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  • 子宮頸癌例でのセンチネルリンパ節同定に用いる新規トレーサーの開発(Development of novel tracers for sentinel node identification in cervical cancer)

    Kodama Keisuke, Tateishi Chuya, Oda Tsuyoshi, Cui Lin, Kuramoto Kazutaka, Yahata Hideaki, Okugawa Kaoru, Maenohara Shoji, Yagi Hiroshi, Yasunaga Masafumi, Onoyama Ichiro, Asanoma Kazuo, Mori Takeshi, Katayama Yoshiki, Kato Kiyoko

    Cancer Science   114 ( 11 )   4216 - 4224   2023.11   ISSN:1347-9032

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    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

    センチネルリンパ節(SLN)を同定するためのトレーサーとして、リポソーム封入インドシアニングリーン(ICG)とフィチン酸塩で構成される新規な蛍光トレーサーを開発し、その有効性と安全性を調査した。まず、安定化したICGが封入されているリポソームを調製した。次にキレート反応が発揮されることを期待し、Ca2+の存在下でリポソームとフィチン酸塩を混和した。その結果、生成される粒子のサイズとその表面の陰電荷が共に増加した。このようにICG、リポソーム、フィチン酸塩を構成要素とした新規トレーサーがマウスのリンパ節内に滞留する時間を評価した。その結果、対照のトレーサー(ICGおよびリポソーム封入ICG)と比較して最も良好な滞留性を発揮した。その蛍光強度比は6時間かけて上昇し、次いで24時間かけて緩やかに低下していった。ブタで安全性評価を行ったが、本新規トレーサーを投与しても死亡または体重減少は発生しなかった。ICGのみ投与した場合との明確な違いも示されず、全安全性は良好であった。本新規トレーサーは、後腹膜アプローチのためリンパ節を同定する時間が必要になる婦人科癌で有用なものになると考えられた。

  • Development of novel tracers for sentinel node identification in cervical cancer. International journal

    Keisuke Kodama, Chuya Tateishi, Tsuyoshi Oda, Lin Cui, Kazutaka Kuramoto, Hideaki Yahata, Kaoru Okugawa, Shoji Maenohara, Hiroshi Yagi, Masafumi Yasunaga, Ichiro Onoyama, Kazuo Asanoma, Takeshi Mori, Yoshiki Katayama, Kiyoko Kato

    Cancer science   114 ( 11 )   4216 - 4224   2023.11   ISSN:1347-9032 eISSN:1349-7006

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    Language:English   Publishing type:Research paper (scientific journal)  

    Indocyanine green (ICG) with near-infrared (NIR) fluorescence imaging is used for lymphatic mapping. However, binding of ICG to blood proteins like serum albumin can shorten its retention time in sentinel lymph nodes (SLNs). Here, we investigated the efficacy and safety of a new fluorescence tracer comprising phytate and liposome (LP)-encapsulated ICG. Coadministration of phytate with LP containing phosphatidic acid promotes chelation mediated by Ca2+ in bodily fluids to enhance SLN retention. Uniformly sized LPs (100 nm) encapsulating ICG under conditions that minimized fluorescence self-quenching during storage were produced. We analyzed the behavior of the new tracer (ICG-phytate-LP) and control tracers (ICG and ICG-LP) in the lymphatic flow of mice in terms of lymph node retention time. We also tested lymphatic flow and safety in pigs that have a more human-like lymphatic system. LPs encapsulating stabilized ICG were successfully prepared. Mixing LP with phytate in the presence of Ca2+ increased both the particle size and negative surface charge. In mice, ICG-phytate-LP had the best lymph node retention, with a fluorescence intensity ratio that increased over 6 h and then decreased slowly over the next 24 h. In pigs, administration of ICG and ICG-phytate-LP resulted in no death or weight loss. There were no obvious differences between blood test results for the ICG and ICG-phytate-LP groups, and the overall safety was good. ICG-phytate-LP may be a useful new tracer for gynecological cancers that require time for lymph node identification due to a retroperitoneal approach.

    DOI: 10.1111/cas.15927

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  • Ipsilateral Right Angular Pregnancy After a Laparoscopic Right Salpingo-Oophorectomy: A Case Report

    To Genichiro, Kodama Keisuke, Onoyama Ichiro, Yahata Hideaki, Kato Kiyoko

    Cureus   15 ( 9 )   e46171   2023.9   ISSN:21688184

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    It can be difficult to distinguish an interstitial pregnancy from an angular pregnancy because of the close proximity of the implantation sites. The difference in pregnancy outcomes between interstitial and angular pregnancies makes this distinction very important. A 39-year-old gravida 7 para 4 who had undergone a laparoscopic right salpingo-oophorectomy (RSO) one year ago and a pregnancy termination via dilation and curettage (D&C) three weeks ago was suspected to have a ruptured right interstitial or angular pregnancy. The patient underwent a laparoscopic total hysterectomy. The postoperative histologic diagnosis was an abortion of a right angular pregnancy. Indeed, it is essential to rule out an interstitial or angular pregnancy during adnexal surgery, even soon after elective abortion. Proper management of an angular pregnancy could prevent a fatal outcome following a rupture or massive hemorrhage.

    CiNii Research

  • Ipsilateral Right Angular Pregnancy After a Laparoscopic Right Salpingo-Oophorectomy: A Case Report. International journal

    Genichiro To, Keisuke Kodama, Ichiro Onoyama, Hideaki Yahata, Kiyoko Kato

    Cureus   15 ( 9 )   e46171   2023.9   ISSN:2168-8184 eISSN:2168-8184

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    It can be difficult to distinguish an interstitial pregnancy from an angular pregnancy because of the close proximity of the implantation sites. The difference in pregnancy outcomes between interstitial and angular pregnancies makes this distinction very important. A 39-year-old gravida 7 para 4 who had undergone a laparoscopic right salpingo-oophorectomy (RSO) one year ago and a pregnancy termination via dilation and curettage (D&C) three weeks ago was suspected to have a ruptured right interstitial or angular pregnancy. The patient underwent a laparoscopic total hysterectomy. The postoperative histologic diagnosis was an abortion of a right angular pregnancy. Indeed, it is essential to rule out an interstitial or angular pregnancy during adnexal surgery, even soon after elective abortion. Proper management of an angular pregnancy could prevent a fatal outcome following a rupture or massive hemorrhage.

    DOI: 10.7759/cureus.46171

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  • Decision-making for Subsequent Therapy for Patients With Recurrent or Advanced Endometrial Cancer Based on the Platinum-free Interval Reviewed International journal

    Yasunaga M, Yahata H, Okugawa K, Hori E, Hachisuga K, Maenohara S, Kodama K, Yagi H, Ohgami T, Onoyama I, Asanoma K, Kato K.

    American Journal of Clinical Oncology   46 ( 9 )   387 - 391   2023.6   ISSN:0277-3732 eISSN:1537-453X

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    OBJECTIVE: The aim of this study was to evaluate the progression-free survival (PFS) and overall response rate (ORR) of patients with recurrent endometrial cancer (REC) or advanced endometrial cancer (AEC) retreated with platinum-containing chemotherapy (PCC) based on the platinum-free interval (PFI). We compared our results with those reported in the KEYNOTE-775 study (that used pembrolizumab plus lenvatinib). METHODS: A retrospective analysis was conducted of 65 patients with REC or AEC retreated with PCC between 2005 and 2020 at our hospital. Various clinicopathologic variables were analyzed: (1) age, (2) performance status, (3) histology, (4) history of pelvic irradiation in the adjuvant setting, (5) PFI, (6) chemotherapy regimen, (7) PFS and overall survival after retreatment with PCC, and (8) best ORR. Survival analyses were performed using Kaplan-Meier curves and log-rank tests. RESULTS: The best ORR and PFS were 43.3% and 9.5 months, respectively, in patients with REC/AEC with a PFI ≥6 months. These results were comparable with those of patients treated with pembrolizumab and lenvatinib. The best ORR and PFS of patients with a PFI of <6 months appeared to be inferior to those of patients treated with pembrolizumab plus lenvatinib. CONCLUSIONS: Pembrolizumab plus lenvatinib seems to be a better treatment choice for patients with REC or AEC with a PFI of <6 months. For a PFI of ≥6 months, pembrolizumab plus lenvatinib or PCC can be used depending on the degree of residual side -effects associated with cytotoxic agents.

    DOI: 10.1097/COC.0000000000001021

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  • Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer

    Onoyama, I; Kawakami, M; Hachisuga, K; Maenohara, S; Kodama, K; Yagi, H; Yasunaga, M; Ohgami, T; Asanoma, K; Yahata, H; Kitamura, Y; Sakamoto, R; Kiyozawa, D; Kato, K

    REPORTS   6 ( 2 )   2023.6   eISSN:2571-841X

  • 特集 子宮体部悪性腫瘍の最前線 Ⅰ.研究の最前線 3.子宮肉腫研究の最前線

    小野山 一郎, 加藤 聖子

    産科と婦人科   90 ( 3 )   245 - 250   2023.3   ISSN:03869792

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    Publisher:診断と治療社  

    DOI: 10.34433/og.0000000065

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  • Tumor-derived ARHGAP35 mutations enhance the Ga13-Rho signalling axis in human endometrial cancer

    Yagi, H; Kawakami, M; Maenohara, S; Kodama, K; Matsumura, Y; Onoyama, I; Asanoma, K; Kato, K

    CANCER SCIENCE   114   1863 - 1863   2023.2   ISSN:1347-9032 eISSN:1349-7006

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  • Epigenetic characterization of ovarian serous carcinoma with lymph-node metastasis by 5-hydroxymethylcytosine sequencing

    Onoyama, I; Kato, M; Kawakami, M; Maenohara, S; Kodama, K; Yagi, H; Asanoma, K; Kato, K

    CANCER SCIENCE   114   918 - 918   2023.2   ISSN:1347-9032 eISSN:1349-7006

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  • 子宮体癌再発を疑った大網放線菌症の1例

    清武 早紀, 安永 昌史, 蜂須賀 一寿, 安武 伸子, 前之原 章司, 八木 裕史, 大神 達寛, 小野山 一郎, 奥川 馨, 淺野間 和夫, 矢幡 秀昭, 加藤 聖子

    福岡産科婦人科学会雑誌   46 ( 2 )   18 - 22   2023.1   ISSN:2187-7211

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    Language:Japanese   Publisher:福岡産科婦人科学会  

    症例は76歳、3妊3産。不正性器出血を主訴に前医を受診し、子宮内膜肥厚を認め、精査加療目的に当科を紹介受診した。当科の子宮内膜全面掻爬にて子宮内膜異型増殖症の診断で、全腹腔鏡下単純子宮全摘出術+両側付属器摘出術を施行した。最終診断は子宮体癌IA期、類内膜癌G1の診断で、再発低リスク群であり、追加治療は施行せず経過観察とした。2年後の造影CT検査で大網左側に結節状の軟部陰影と周囲脂肪織混濁を認め再発が疑われた。CTガイド下生検を施行し、病理組織検査で非特異的な炎症所見を認めるのみで、悪性所見は認めなかった。更に1年後のCTで軟部陰影は増大傾向であり、子宮体癌再発の可能性も否定できず、診断確定目的に大網部分切除術を施行した。最終病理組織診断の結果は放線菌症の診断であった。放線菌症は悪性腫瘍との鑑別が難しいため、非典型的な臨床経過の場合は放線菌感染も鑑別の一つとして念頭においておくべきと思われた。(著者抄録)

  • Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer Reviewed

    小野山 一郎

    Reports   -   2023

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  • ステージIAの再発リスクの低い子宮内膜癌患者において肥満がロボット支援手術に及ぼす影響 施設研究(Impact of obesity on robotic-assisted surgery in patients with stage IA endometrial cancer and a low risk of recurrence: An institutional study)

    Asanoma Kazuo, Yahata Hideaki, Okugawa Kaoru, Ohgami Tatsuhiro, Yasunaga Masafumi, Kodama Keisuke, Onoyama Ichiro, Kenjo Hironori, Shimokawa Mototsugu, Kato Kiyoko

    The Journal of Obstetrics and Gynaecology Research   48 ( 12 )   3226 - 3232   2022.12   ISSN:1341-8076

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    ロボット支援手術が施行された子宮内膜癌患者63例を対象とした後向きコホート研究を実施し、肥満がロボット支援手術の安全性および質に及ぼす影響について検討した。患者を非肥満群40例(BMI:30未満、中央値54歳)、肥満群13例(BMI:30以上35未満、中央値54歳)、病的肥満10例(BMI;35以上、中央値50歳)に分類した。評価項目は手術時間、出血量、周術期合併症、再発率とした。その結果、開腹術への移行は非肥満群1例、病的肥満群1例であった。総手術時間、セッティング時間(トロッカー留置、ダヴィンチロボットドッキングを含む)、コンソール時間、創部閉鎖時間に群間差は認められなかったが、セッティングおよび創部閉鎖の合計時間に群間差が認められた。出血量や合併症には群間差が認められた。非肥満群3例、肥満群2例に対して、術後補助療法が実施されたが、平均観察期間21ヵ月において再発は認められなかった。非肥満群2例、肥満群1例が平均観察期間38ヵ月に再発していた。以上から、肥満を呈する子宮内膜癌患者に対するロボット支援手術の安全性が示された。

  • Impact of obesity on robotic-assisted surgery in patients with stage IA endometrial cancer and a low risk of recurrence: An institutional study. International journal

    Kazuo Asanoma, Hideaki Yahata, Kaoru Okugawa, Tatsuhiro Ohgami, Masafumi Yasunaga, Keisuke Kodama, Ichiro Onoyama, Hironori Kenjo, Mototsugu Shimokawa, Kiyoko Kato

    The journal of obstetrics and gynaecology research   48 ( 12 )   3226 - 3232   2022.12   ISSN:1341-8076 eISSN:1447-0756

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    AIM: Westernization of lifestyle has increased the numbers of patients with endometrial cancer and obesity. This study aimed to compare the clinical outcomes of robotic-assisted surgery according to whether patients are obese, morbidly obese, or nonobese. METHODS: Sixty-three patients with endometrial cancer who underwent robotic-assisted surgery between March 2014 and June 2022 were categorized according to whether they had a body mass index (BMI) <30 (group A, nonobese, n = 40), ≥30 and <35 (group B, obese, n = 13), or ≥35 (group C, morbidly obese, n = 10). Operation time, blood loss, perioperative complications, and recurrence rate were investigated. RESULTS: Conversion to laparotomy was required in one case in group A and one in group C. There was no difference in total operation time, time for setting (including trocar installation and docking of the da Vinci robot), console time, or time for wound closure between the groups; however, there was a significant between-group difference in the total time for setting and wound closure. There was no significant difference in blood loss or complications between the groups. Three patients in group A and two in group B received adjuvant treatment; none have shown evidence of recurrent disease during a mean observation time of 21 months (range, 2-29). Two cases in group A and one in group B had recurrence during a mean observation time of 38 months (range, 19-46). CONCLUSION: Patients with endometrial cancer who are obese can be treated safely by robotic-assisted surgery with a low risk of complications and few relapses.

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  • Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer. Reviewed International journal

    Yagi H, Onoyama I, Asanoma K, Kawakami M, Maenohara S, Kodama K, Matsumura Y, Hamada N, Hori E, Hachisuga K, Yasunaga M, Ohgami T, Okugawa K, Yahata H, Kato K.

    Cancer Gene Ther.   30 ( 2 )   313 - 323   2022.10   ISSN:0929-1903 eISSN:1476-5500

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    Dysregulated G protein-coupled receptor signaling is involved in the formation and progression of human cancers. The heterotrimeric G protein Gα13 is highly expressed in various cancers and regulates diverse cancer-related transcriptional networks and cellular functions by activating Rho. Herein, we demonstrate that increased expression of Gα13 promotes cell proliferation through activation of Rho and the transcription factor AP-1 in human endometrial cancer. Of interest, the RhoGTPase activating protein (RhoGAP), ARHGAP35 is frequently mutated in human endometrial cancers. Among the 509 endometrial cancer samples in The Cancer Genome Atlas database, 108 harbor 152 mutations at 126 different positions within ARHGAP35, representing a somatic mutation frequency of 20.2%. We evaluated the effect of 124 tumor-derived ARHGAP35 mutations on Gα13-mediated Rho and AP-1 activation. The RhoGAP activity of ARHGAP35 was impaired by 55 of 124 tumor-derived mutations, comprised of 23 nonsense, 15 frame-shift, 15 missense mutations, and two in-frame deletions. Considering that ARHGAP35 is mutated in >2% of all tumors, it ranks among the top 30 most significantly mutated genes in human cancer. Our data suggest potential roles of ARHGAP35 as an oncogenic driver gene, providing novel therapeutic opportunities for endometrial cancer.

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  • 再発子宮頸癌に対するペムブロリズマブ療法中に内腸骨動脈-S状結腸瘻を生じた一例(Arterio-enteric fistula in a patient with recurrent cervical cancer treated with pembrolizumab)

    永谷 優華, 八木 裕史, 久保 雄一郎, 牛島 泰宏, 堀 絵美子, 川上 穣, 友延 寛, 安武 伸子, 吉田 祥子, 小玉 敬亮, 安永 昌史, 大神 達寛, 小野山 一郎, 奥川 馨, 淺野間 和夫, 谷口 秀一, 嶋本 富博, 矢幡 秀昭, 石神 康生, 加藤 聖子

    宮崎県医師会医学会誌   46 ( 2 )   147 - 153   2022.9   ISSN:0389-8288

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    動脈-腸管瘻は消化管出血の原因としてはまれであるが,初発症状が致死性の大量出血の場合もある緊急性の高い疾患である。症例は44歳,9妊7産,子宮頸癌IB3期(扁平上皮癌)に対して広汎子宮全摘出術,両側付属器摘出術,術後補助療法として同時化学放射線療法を施行した。治療終了6ヵ月後に骨盤内再発を認め,全身化学療法を施行したが奏効しなかった。MSI検査の結果,MSI-highであったためペムブロリズマブ療法を開始した。腫瘍の著明な縮小を認め,4コース後の治療効果判定はPRであった。ペムブロリズマブ療法4コース目day7,当科入院中に突然,多量の下血,意識レベルの低下を認めた。緊急造影CTの結果,左内腸骨動脈からS状結腸への造影剤の漏出を認め,左内腸骨動脈-S状結腸瘻と診断した。直ちに左内腸骨動脈塞栓術を施行し止血した。発症から止血まで3時間の間に赤血球32単位,新鮮凍結血漿28単位,血小板10単位の輸血を要した。(著者抄録)

  • Prognostic impact of adding bevacizumab to carboplatin and paclitaxel for recurrent, persistent, or metastatic cervical cancer. International journal

    Masafumi Yasunaga, Hideaki Yahata, Kaoru Okugawa, Mototsugu Shimokawa, Yumiko Maeda, Emiko Hori, Keisuke Kodama, Hiroshi Yagi, Tatsuhiro Ohgami, Ichiro Onoyama, Kazuo Asanoma, Kiyoko Kato

    Taiwanese journal of obstetrics & gynecology   61 ( 5 )   818 - 822   2022.9   ISSN:1028-4559

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    OBJECTIVE: Recent randomized phase III trial has shown significant benefit in overall survival (OS) for patients with advanced cervical cancer by adding bevacizumab to conventional chemotherapy. The aim of this study was to evaluate the prognostic impact for Japanese recurrent, persistent, or metastatic cervical cancer patients where bevacizumab was added to paclitaxel plus carboplatin. MATERIALS AND METHODS: A retrospective analysis was performed on 90 patients with recurrent, persistent, or metastatic cervical cancer mainly treated by paclitaxel plus carboplatin between 2005 and 2019 at our hospital. Data for the following clinicopathological variables were analyzed: (1) bevacizumab use; (2) histology; (3) disease presentation; (4) performance status; (5) prior chemotherapy containing platinum agent; (6) pelvic disease; (7) prior pelvic radiotherapy; (8) location of target lesions. Survival analysis was performed using Kaplan-Meier curves, log-rank tests, Wilcoxon tests, and Cox proportional hazards models combined with propensity score matching. RESULTS: Adding bevacizumab to paclitaxel plus carboplatin showed significantly increased complete response to compared with that of non-users. In a Cox regression hazard model, bevacizumab use tended to show better OS though without statistically significance. After propensity score matching, adding bevacizumab to paclitaxel plus carboplatin showed a significant better OS by univariate analysis using Wilcoxon test, not by log-rank test. CONCLUSION: Adding bevacizumab to paclitaxel plus carboplatin showed a limited prognostic impact for recurrent, persistent or advanced cervical cancer patients in the real world. Further effective second-line treatments are needed to prolong OS of patients with recurrent, persistent or advanced cervical cancer.

    DOI: 10.1016/j.tjog.2022.06.005

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  • Evaluation of Clinical Significance of Lymphovascular Space Invasion in Stage IA Endometrial Cancer Invited Reviewed International journal

    Okugawa, Kaoru; Yahata, Hideaki; Hachisuga, Kazuhisa; Tomonobe, Hiroshi; Yasutake, Nobuko; Kodama, Keisuke; Kenjo, Hironori; Yagi, Hiroshi; Ohgami, Tatsuhiro; Yasunaga, Masafumi; Onoyama, Ichiro; Asanoma, Kazuo; Hori, Emiko; Ohishi, Yoshihiro; Oda, Yoshinao; Kato, Kiyoko

    ONCOLOGY   100 ( 4 )   195 - 202   2022.4   ISSN:0030-2414 eISSN:1423-0232

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    INTRODUCTION: The prognostic significance of lymphovascular space invasion (LVSI) in stage IA endometrial cancer remains unclear. The aim of this study was to evaluate the clinical significance of LVSI in stage IA endometrial cancer. METHODS: Clinical data of patients with stage IA endometrial cancer who underwent initial surgery at our institution between January 2008 and December 2018 were reviewed retrospectively. Information of patients, surgery, and characteristics of cancer were obtained from medical records and pathological reports. RESULTS: Two hundred ninety-seven patients were enrolled in this study. With a median follow-up of 60 months, 15 patients experienced recurrence (5.1%) and 4 patients died of endometrial cancer (1.3%). The recurrence and mortality rates did not differ significantly between the LVSI-positive and -negative groups (p = 0.07 and p = 0.41, respectively). Recurrence-free survival and endometrial cancer-specific survival also did not differ significantly between these groups (p = 0.11 and p = 0.49, respectively). The 5-year endometrial cancer-specific survival rates for tumors with and without LVSI were 97.0% and 98.9%, respectively. Among patients with low-grade tumors, recurrence-free survival and endometrial cancer-specific survival did not differ significantly between patients with tumors with and without LVSI (p = 0.92 and p = 0.72, respectively). The 5-year endometrial cancer-specific survival rates for low-grade tumors with and without LVSI were 100% and 99.3%, respectively. CONCLUSION: LVSI was not a prognostic factor of not only stage IA endometrial cancer but also stage IA low-grade cancer.

    DOI: 10.1159/000521382

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  • Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer. International journal

    Hideaki Yahata, Keisuke Kodama, Kaoru Okugawa, Kazuhisa Hachisuga, Nobuko Yasutake, Shoji Maenohara, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Kazuo Asanoma, Hiroaki Kobayashi, Kenzo Sonoda, Shingo Baba, Kousei Ishigami, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato

    Gynecologic oncology   165 ( 1 )   149 - 154   2022.4   ISSN:0090-8258 eISSN:1095-6859

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    OBJECTIVE: Sentinel node biopsy alone (SNB) reduces the postoperative complications of pelvic lymphadenectomy, such as lymphedema and lymphangitis; however, the long-term prognosis after SNB is unclear. The objective of this study was to evaluate the long-term outcome and complications of patients with early-stage cervical cancer who underwent SNB for hysterectomy or trachelectomy. METHODS: We performed SNB for cervical cancer using a radioisotope method in 181 patients between 2009 and 2017. If the intraoperative sentinel lymph node evaluation was negative for metastasis, no further lymph nodes were removed. RESULTS: The median age of the patients was 34 years (range, 21-73 years). The International Federation of Gynecology and Obstetrics 2008 stage was IA1 in 6 patients, IA2 in 18, IB1 in 154, and IIA1 in 3. Of the 181 patients (44 with hysterectomy, 137 with trachelectomy), 8 did not undergo pelvic lymphadenectomy because of a false-negative intraoperative diagnosis, 20 received adjuvant therapy after surgery, and 4 (2.2%) experienced recurrence over a median follow-up period of 83.5 months (range, 25-145 months). In the four recurrent cases, recurrence occurred in the pelvis, lung, and bone in one patient each, while the remaining patient developed pelvic and para-aortic lymph node metastases. Of these four patients, one died, and the remaining three are alive without disease after multidisciplinary therapy. The 5-year progression-free and overall survival rates were 98.8% and 99.4%, respectively. Postoperative complications, such as lymphedema, were very low rate. CONCLUSIONS: SNB for early-stage cervical cancer might be safe and effective, with no increase in the recurrence and postoperative complications rate.

    DOI: 10.1016/j.ygyno.2022.01.031

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  • Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer Invited Reviewed International journal

    Hideaki Yahata, Keisuke Kodama, Kaoru Okugawa, Kazuhisa Hachisuga, Nobuko Yasutake, Shoji Maenohara, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Kazuo Asanoma, Hiroaki Kobayashi, Kenzo Sonoda, Shingo Baba, Kousei Ishigami, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato

    Gynecol Oncol   2022.2

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  • Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia

    Onoyama, I; Kato, M; Kawakami, M; Kodama, K; Yagi, H; Asanoma, K; Kato, K

    CANCER SCIENCE   113   727 - 727   2022.2   ISSN:1347-9032 eISSN:1349-7006

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  • Tumor-derived mutations in ARHGAP35 promote Gα<sub>13</sub>-induced AP1 activation in human endometrial cancer cells

    Yagi, H; Kodama, K; Matsumura, Y; Onoyama, I; Asanoma, K; Kato, K

    CANCER SCIENCE   113   1539 - 1539   2022.2   ISSN:1347-9032 eISSN:1349-7006

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  • Prognostic impact of the subclassification of Müllerian cancer stage IV in the FIGO 2014 staging system with a focus of extra-abdominal lymph node metastases. Invited Reviewed International journal

    2021.7

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  • YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer Invited Reviewed International journal

    Suzuki, Izumi; Yoshida, Sachiko; Tabu, Kouichi; Kusunoki, Soshi; Matsumura, Yumiko; Izumi, Hiroto; Asanoma, Kazuo; Yagi, Hiroshi; Onoyama, Ichiro; Sonoda, Kenzo; Kohno, Kimitoshi; Taga, Tetsuya; Itakura, Atsuo; Takeda, Satoru; Kato, Kiyoko

    SCIENTIFIC REPORTS   11 ( 1 )   2021.2

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    DOI: 10.1038/s41598-021-83200-5

  • Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells Invited Reviewed International journal

    Yoshida, Sachiko; Asanoma, Kazuo; Yagi, Hiroshi; Onoyama, Ichiro; Hori, Emiko; Matsumura, Yumiko; Okugawa, Kaoru; Yahata, Hideaki; Kato, Kiyoko

    BMC CANCER   21 ( 1 )   2021.2

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    DOI: 10.1186/s12885-021-07875-9

  • Identification of genes associated with endometrial cell ageing Invited Reviewed International journal

    Kawamura, Teruhiko; Tomari, Hiroyuki; Onoyama, Ichiro; Araki, Hiromitsu; Yasunaga, Masafumi; Lin, Cui; Kawamura, Keiko; Yokota, Natsuko; Yoshida, Sachiko; Yagi, Hiroshi; Asanoma, Kazuo; Sonoda, Kenzo; Egashira, Katsuko; Ito, Takashi; Kato, Kiyoko

    MOLECULAR HUMAN REPRODUCTION   27 ( 2 )   2021.2

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    DOI: 10.1093/molehr/gaaa078

  • Evaluation of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer: a single-institution experience. Invited Reviewed International journal

    Okugawa K, Yahata H, Sonoda K, Kodama K, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Kaneki E, Asanoma K, Kobayashi H, Kato K.

    Int J Clin Oncol   2020.9

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  • Nonlinear Optics with Near-Infrared Excitation Enable Real-Time Quantitative Diagnosis of Human Cervical Cancers. Invited Reviewed International journal

    Matsui T, Tamoto R, Iwasa A, Mimura M, Taniguchi S, Hasegawa T, Sudo T, Mizuno H, Kikuta J, Onoyama I, Okugawa K, Shiomi M, Matsuzaki S, Morii E, Kimura T, Kato K, Kiyota Y, Ishii M.

    Cancer Res   2020.9

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  • Is Adjuvant Therapy Necessary for Patients with Intermediate-Risk Cervical Cancer after Open Radical Hysterectomy? Invited Reviewed International journal

    Yahata H, Sonoda K, Inoue S, Yasutake N, Kodama K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Asanoma K, Kato K.

    Oncology   2020.7

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  • Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10-year experience of a single institute. Reviewed International journal

    Kodama K, Sonoda K, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Yahata H, Ohishi Y, Oda Y, Kato K.

    Asia Pac J Clin Oncol.   2020.4

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  • Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer. Reviewed International journal

    Kato M, Onoyama I, Yoshida S, Cui L, Kawamura K, Kodama K, Hori E, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K

    Int J Cancer.   2020.3

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  • Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer. Reviewed International journal

    2019.12

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  • Survey of the desire to have children and engage in sexual activity after trachelectomy among young Japanese women with early-stage cervical cancer. Reviewed International journal

    Yahata H, Sonoda K, Okugawa K, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Kaneki E, Asanoma K, Kato K.

    J Obstet Gynaecol Res.   2019.11

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  • Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells. Reviewed International journal

    Asanoma K, Hori E, Yoshida S, Yagi H, Onoyama I, Kodama K, Yasunaga M, Ohgami T, Kaneki E, Okugawa K, Yahata H, Kato K

    Oncotarget   2019.7

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  • Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer. Reviewed International journal

    Yahata H, Kobayashi H, Sonoda K, Kodama K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Baba S, Isoda T, Ohishi Y, Oda Y, Kato K

    Int J Clin Oncol.   2018.12

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  • Two types of small cell carcinoma of the ovary: Two typical case reports. Reviewed International journal

    Yoshida Y, Kaneki E, Kijima M, Kodama K, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Okugawa K, Yahata H, Sonoda K, Kato K.

    Gynecol Oncol Rep   2018.7

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  • Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway Reviewed International journal

    2018.3

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    DOI: 10.1016/j.ajpath.2017.11.008

  • FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors Reviewed International journal

    Ichiro Onoyama

    Cancer Science   in press   2016.8

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  • 子宮肉腫研究の最前線

    小野山一郎、加藤聖子( Role: Joint author)

    2023.3 

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  • 子宮肉腫研究の最前線

    小野山 一郎

    診断と治療社  2023 

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  • 子宮肉腫研究の最前線

    小野山一郎, 加藤聖子

    産科と婦人科   2023.3

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  • 【子宮体部悪性腫瘍の最前線】研究の最前線 子宮肉腫研究の最前線

    小野山 一郎, 加藤 聖子

    産科と婦人科   90 ( 3 )   245 - 250   2023.3   ISSN:0386-9792

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    <文献概要>子宮平滑筋肉腫,子宮がん肉腫などの子宮肉腫は稀少であるが予後不良な疾患であり,既存の抗悪性腫瘍薬が効かないことも多い.近年,急速に発達したゲノム解析技術を活用し,様々な悪性腫瘍に対して新たな治療法の開発が進行している.子宮肉腫で認める遺伝子異常はこの疾患に特異的なものだけではなく,ほかの悪性腫瘍でも認めるものが多い.他がん腫で進められている研究成果を活用して子宮肉腫に最適化し,より有効な治療法を模索することが重要である.

  • 子宮内膜がんに対する分子標的薬

    小野山 一郎, 加藤 聖子

    2016.8

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    子宮内膜がんは欧米諸国において最も頻度の高い婦人科悪性腫瘍であり、日本においてもその罹患数は増加している。国立がん研究センターの統計では1975年の粗罹患率が10万人あたり1.6人であるのに対し、2011年には22.5人に増加している。子宮内膜がんはエストロゲンの刺激が長期間持続することが原因で発生する場合があり、そのリスクファクターとして以前から食事の欧米化、肥満、出産経験がないことなどが知られており、近年罹患数が増えている原因と考えられる。
    現在、子宮内膜がんの標準治療には手術療法、化学療法、放射線療法、そしてホルモン療法がある。近年、種々のがんに対する分子標的薬が開発され、臨床の場でも使われるようになっているが、ホルモン療法を除き、いまだ子宮内膜がんに対する標準治療として使用できる分子標的薬はない。しかし、種々の解析によって発がん・進展機構の分子基盤が明らかとなるに従い、臨床試験レベルでも多くの分子標的薬がその効果を検討されるようになった。
    本稿では、近年明らかにされつつある子宮内膜がんの分子生物学的特徴に触れつつ、現在開発中または臨床試験中の分子標的薬について解説する。最後に、現在研究が進められている子宮内膜がんのがん幹細胞について、これまで得られている知見と分子標的薬開発の方向性について解説する。

Professional Memberships

  • Japan Society of Obstetrics and Gynecology

  • 日本癌学会

  • 日本臨床細胞学会

  • 日本婦人科腫瘍学会

  • 日本癌治療学会

  • 日本婦人科腫瘍学会

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  • Japan Society of Obstetrics and Gynecology

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  • 日本癌学会

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  • 日本癌治療学会

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  • 日本臨床細胞学会

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Academic Activities

  • Reports International contribution

    2023.5 - 2026.5

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 司会(Moderator)

    生殖医学フォーラム  ( 石川県加賀市 ) 2017.6

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

Research Projects

  • 卵巣癌におけるゲノムワイドな5hmC解析と臨床病理学的因子に関する研究

    Grant number:2 3 K 0 8 8 0 0  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 卵巣癌におけるゲノムワイドな5hmC解析と臨床病理学的因子に関する研究

    Grant number:23K08800  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 卵巣漿液性癌におけるDNA脱メチル化産物5hmCと転移に関する研究

    2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 5-hydroxymethylcytosine and clinicopathological features in ovarian serous carcinoma

    Grant number:20K09646  2020 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Onoyama Ichiro

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    Authorship:Principal investigator  Grant type:Scientific research funding

    This project revealed that ovarian cancer cells showed higher levels of 5hmC compared with epithelial cells of normal ovary and fallopian tube. Notably, high-grade serous carcinomas (HGSCs) with lymph-node (LN) metastasis showed significantly higher levels of 5hmC compared with those without LN metastasis. Genome-wide 5hmC sequencing showed 5hmCs were adjacent to various oncogenes in HGSC cases regardless of LN metastasis, however, comparative gene ontology analysis revealed some characteristic pathways specific to HGSCs with LN metastasis.
    These data indicated that epigenetic changes of 5hmC levels and their distributions could be implicated in LN metastasis in ovarian HGSCs.

    CiNii Research

  • DNA脱メチル化酵素TET3の発癌、腫瘍進展における生理学的役割の解明

    2016 - 2018

    平成28年度臨床研究助成

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    Authorship:Principal investigator  Grant type:Contract research

Educational Activities

  • I teach biological experiments to post-graduate students.

Class subject

  • 婦人科がん

    2023.10 - 2024.3   Second semester

  • 外陰疾患

    2023.10 - 2024.3   Second semester

  • 外陰疾患

    2022.10 - 2023.3   Second semester

  • 婦人科がん

    2022.10 - 2023.3   Second semester

  • 婦人科がん

    2021.10 - 2022.3   Second semester

  • 外陰疾患

    2021.10 - 2022.3   Second semester

  • 外陰疾患

    2020.10 - 2021.3   Second semester

  • 婦人科がん

    2020.10 - 2021.3   Second semester

  • 婦人科がん

    2019.10 - 2020.3   Second semester

  • 婦人科がん

    2018.10 - 2019.3   Second semester

  • 産婦人科クリニカルクラークシップ

    2018.4 - 2018.9   First semester

  • 婦人科がん

    2017.10 - 2018.3   Second semester

  • 各種がんの治療

    2016.10 - 2017.3   Second semester

  • 臨床実習Ⅰ

    2016.10 - 2017.3   Second semester

  • 臨床実習Ⅰ

    2016.4 - 2016.9   First semester

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Participation in international educational events, etc.

  • 2024.3

    TG-MET Center

    International workshop 2024

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    Venue:タイ・バンコク

  • 2019.3

    九州大学病院国際医療部

    平成30年度九州大学病院椎木基金支援助成事業短期海外研修プログラム

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    Venue:フィリピン、マカティ

    Number of participants:9

Outline of Social Contribution and International Cooperation activities

  • I contribute to community medicine with cancer screening and prenatal care.
    I support ward training of foreign students in OB/GY department.

Travel Abroad

  • 2016.3

    Staying countory name 1:United States   Staying institution name 1:University of Massachusetts Medical School

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Obstetrics and Gynecology

Clinician qualification

  • Certifying physician

    Japan Society of Obstetrics and Gynecology(JSOG)

  • Certifying physician

    日本がん治療認定医機構

Year of medical license acquisition

  • 1999

Notable Clinical Activities

  • 九州大学病院産婦人科における婦人科悪性腫瘍研究機構(JGOG)の担当として、臨床試験に関わっている。 副病棟医長として、婦人科の外来、手術全般に関するマネージメントを行っている。