HACHISUGA KAZUHISA
Organization
Kyushu University Hospital Gynecology & Obstetrics Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Contact information
Profile
九州大学病院産婦人科における臨床業務および研究活動
学生への講義
External link
Research Interests・Research Keywords
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Research theme：Clinical significance of p53 expression in low-grade endometrial cancer
Keyword：p53expression, low-grade endometrial cancer, L1CAM
Research period： 2024.4
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Research theme：Clinical significance of tumor immune microenvironment in endometrial endometrioid carcinoma, grade 1 with DNA mismatch repair protein loss
Keyword：endometrioid carcinoma, G1; MMR loss; tumor immune microenvironment; ICI therapies
Research period： 2022.10
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Research theme：Endometrial endometrioid carcinoma and serous carcinoma are the two most common histologic types of uterine cancer. Although previously classified as Type 1 and Type 2, respectively, a comprehensive genomic analysis of uterine cancer published in 2013 classified uterine cancer into four molecular subtypes. Endometrial endometrioid carcinomas span all four subtypes, and serous carcinomas are essentially in the copy-number high group, which is characterized by abnormal p53 expression and is associated with the poorest prognosis. We have studied 269 cases of endometrial endometrioid carcinoma, G1, and found that abnormal p53 expression was not a significant poor prognostic factor in endometrial endometrioid carcinoma, G1. Therefore, it is important to consider how to treat serous carcinomas and endometrial endometrioid carcinomas with abnormal p53 expression when molecular subtypes are applied to clinical practice in the future. Therefore, we will compare serous carcinomas and endometrial endometrioid carcinomas with abnormal p53 expression using spatial transcriptome technology.
Keyword：endometrial endometiroid carcinoma, endometrial serous carcinoma, p53 expression
Research period： 2022.2 - 2024.3
Papers
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Clinical Significance of Tumor Immune Microenvironment in Endometrial Endometrioid Carcinoma, Grade 1 With DNA Mismatch Repair Protein Loss Invited Reviewed International journal
Kazuhisa Hachisuga, M.D., Ph.D., Minoru Kawakami, M.D., Hiroshi Tomonobe, M.D., Ph.D., Shoji Maenohara, M.D., Ph.D., Keisuke Kodama, M.D., Hiroshi Yagi, M.D., Ph.D., Masafumi Yasunaga, MD., Ph.D., Ichiro Onoyama, M.D., Ph.D., Kazuo Asanoma, M.D., Ph.D., Hideaki Yahata, M.D., Ph.D., Yoshinao Oda, M.D., Ph.D., and Kiyoko Kato, M.D., Ph.D.
International journal of gynecological pathology 2024.4
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Endometrial endometrioid carcinoma, G1, is more aggressive in the elderly than in the young Invited Reviewed International journal
Kazuhisa Hachisuga, Yoshihiro Ohishi, Hiroshi Tomonobe, Hideaki Yahata, Kiyoko Kato,and Yoshinao Oda
Histopathology 2021.11
Presentations
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Clinical significance of p53 immunohistochemical expression in low-grade endometrial cancer
Kazuhisa Hachisuga, M.D., Ph.D., Minoru Kawakami, M.D., Hiroshi Tomonobe, M.D., Ph.D., Shoji Maenohara, M.D., Ph.D., Keisuke Kodama, M.D., Hiroshi Yagi, M.D., Ph.D., Masafumi Yasunaga, MD., Ph.D., Ichiro Onoyama, M.D., Ph.D., Kazuo Asanoma, M.D., Ph.D., Hideaki Yahata, M.D., Ph.D., Yoshinao Oda, M.D., Ph.D., and Kiyoko Kato, M.D., Ph.D.
2024.4
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Clinical significance of tumor immune microenvironment in endometrial endometrioid carcinoma, grade 1 with DNA mismatch repair protein loss 第75回日本産婦人科学会
2023.5
MISC
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体癌のMolecular pathologyと臨床応用 産婦人科の実際 Reviewed
蜂須賀 一寿、加藤 聖子
2023.5
Class subject
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胎盤および周産期に関連する病理
2024.4 - 2024.9 First semester
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胎盤および周産期に関連する病理
2023.4 - 2023.9 First semester
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胎盤および周産期に関連する病理
2022.4 - 2022.9 First semester