Updated on 2025/06/09

写真a

 
INOUE HIROSUKE
 
Organization
Kyushu University Hospital Pediatrics Lecturer
Kyushu University Hospital Pediatrics(Concurrent)
School of Medicine Department of Medicine(Concurrent)
Title
Lecturer
Contact information
メールアドレス
Tel
0926425421
Profile
小児科、特に周産期・新生児医療の診療・研究・教育を行っている。 診療では、当院総合周産期母子医療センターの新生児内科部門において、早産児および合併症を有する新生児に対する全身的集中治療を専門としている。また、出生前のケアおよび退院後のフォローアップも担当し、他科・多職種と連携しながら患児および家族に対し包括的なケアを提供している。 研究では、周産期・新生児医療を中心に基礎研究から臨床研究まで幅広く取り組んでおり、その成果を積極的に発表している。 教育では、医学生、大学院生、および研修医に対して、周産期・新生児医療に関する講義・診療指導・研究指導を行っている。
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External link

Research Areas

  • Life Science / Embryonic medicine and pediatrics

Degree

  • Ph.D in Medicine

Research History

  • Kyushu University Kyushu University Hospital Pediatrics  Lecturer 

    2014.4 - Present

Research Interests・Research Keywords

  • Research theme: perinatal and neonatal medicine

    Keyword: neonate

    Research period: 2014.4 - 2015.9

Awards

  • 第70回九州小児科学会優秀英語論文

    2017.10   九州小児科学会  

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    Early Mortality and Morbidity in Infants with Birth Weight of 500 Grams or Less in Japan.

  • 第69回九州小児科学会優秀論文賞(英文)

    2016.11   九州小児科学会  

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    Activation of Nod1 signaling induces fetal growth restriction and death through fetal and maternal vasculopathy

Papers

  • Onset and Outcome of Ocular Lesions in Neonatal Severe Protein C Deficiency: Case Report and Literature Review

    Miyauchi, Y; Egami, N; Inoue, H; Sonoda, M; Eguchi, K; Ishimura, M; Ochiai, M; Tsukamoto, S; Matsumoto, S; Uchiumi, T; Sonoda, KH; Ohga, S

    PEDIATRIC BLOOD & CANCER   72 ( 3 )   e31518   2025.3   ISSN:1545-5009 eISSN:1545-5017

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    Language:English   Publisher:Pediatric Blood and Cancer  

    Neonatal protein C (PC) deficiency, which presents with purpura fulminans or hemorrhagic infarction, has a poor prognosis. In a sporadic case of prenatal-onset purpura fulminans, preemptive intervention saved the patient but not her vision. Among 38 survivors from 47 cases with ocular lesions and biallelic PROC variants, 23 had total blindness and eight had unilateral blindness. Only one had intact vision. Prenatal-onset ocular lesions occurred in 11 cases (29% [corneal opacities, n = 7; bilateral persistent hyperplastic primary vitreous, n = 1; both, n = 3]). The eyes are the first organ affected by heritable severe PC deficiency. Prenatal intervention is needed to improve visual outcomes.

    DOI: 10.1002/pbc.31518

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  • Expanding diversity in developmental profiles of very-low-birth-weight infants during 6 years after birth

    Watanabe, K; Ogata, R; Kajiwara, K; Inoue, H; Sakemi, Y; Ichiyama, M; Sawano, T; Yasuoka, K; Watabe, T; Kurata, H; Nakashima, T; Sonoda, Y; Chong, PF; Akamine, S; Ochiai, M; Ohno, T; Yamashita, H; Sakai, Y; Ohga, S

    SCIENTIFIC REPORTS   15 ( 1 )   4504   2025.2   ISSN:2045-2322

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    Language:English   Publisher:Scientific Reports  

    Very-low-birth-weight infants (VLBWIs) are at high risk for neurodevelopmental problems after age 3 years. We investigated the association between the developmental quotient (DQ) of VLBWIs and their growth profiles during 6 years after birth. Participants were VLBWIs born at Kokura Medical Center (the first cohort) and Kyushu University Hospital (the second cohort) between 2012 and 2017. Recorded charts were used to collect growth profiles and developmental quotients (DQ) of the participants until age 6 years. In the first cohort (n = 64), the DQ values at age 6 years were correlated with those at age 3 years. VLBWIs with DQ ≥ 85 at age 6 years had a higher body weight and height at age 3 years than those with DQ < 85. The second cohort (n = 69) validated these findings. A comparative analysis of the two cohorts revealed that the DQ of VLBWIs was dissociated from their growth profiles after age 3 years. Clustering analyses indicated that DQ values at age 3 years predicted better the prognosis of VLBWIs with DQ ≥ 85 at age 6 years than their growth profiles. This study demonstrates that VLBWIs gain divergent profiles in growth, development, and growth-and-development correlation during postnatal 6 years.

    DOI: 10.1038/s41598-025-88721-x

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  • Parental occupational exposure to anticancer drugs and radiation: Risk of fetal loss and physical abnormalities in The Japan Environment and Children's Study. International journal

    Shunsuke Yamamoto, Masafumi Sanefuji, Hirosuke Inoue, Masataka Inoue, Yu Shimo, Shunichiro Toya, Maya Suzuki, Nozomi Abe, Norio Hamada, Utako Oba, Kentaro Nakashima, Masayuki Ochiai, Reiko Suga, Yuhki Koga, Mayumi Tsuji, Kiyoko Kato, Shouichi Ohga

    Early human development   201   106195 - 106195   2025.2   ISSN:0378-3782 eISSN:1872-6232

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Early Human Development  

    BACKGROUND: Many studies have indicated an association between maternal occupational exposure to hazardous agents, such as anticancer drugs and ionizing radiation, and an increased risk of adverse pregnancy outcomes, including stillbirths or miscarriages and physical abnormalities in offspring. However, the effects of recent advancements in protective measures to reduce these risks have not been clarified. Aim To investigate the current impact of parental occupational exposure to anticancer drugs and ionizing radiation on stillbirths or miscarriages as well as physical abnormalities under the circumstances of the developed safety protocols. METHODS: This cohort study utilized The Japan Environment and Children's Study dataset, which included 96,606 fetuses born between January 2011 and March 2014. This study focused on the association between occupational exposure to these agents during pregnancy and the incidence of stillbirths or miscarriages and physical abnormalities in offspring, employing Poisson regression models for adjusted relative risk. RESULTS: From the study population, 471 cases of stillbirths or miscarriages and 4493 infants with physical abnormalities were identified. Fisher's exact tests indicated no significant differences in fetal loss or physical abnormalities between the exposure groups. A multivariable analysis also found no significant association between maternal exposure to anticancer drugs and ionizing radiation and these adverse outcomes. CONCLUSION: Under improved safety measures, maternal occupational exposure to anticancer drugs and ionizing radiation does not significantly affect the occurrence of stillbirths or miscarriages and physical abnormalities in offspring. These findings highlight the critical role of current safety practices and indicate lower reproductive risks with proper precautions.

    DOI: 10.1016/j.earlhumdev.2025.106195

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  • Isolated congenital diaphragmatic hernia and three-year neurodevelopmental outcomes

    Toyoshima, K; Aoki, H; Katsumata, K; Sato, Y; Inoue, H; Ito, M; Amari, S; Maruyama, H; Arahori, H; Kondo, T; Kim, K; Yamoto, M; Saito, T; Okuyama, H; Usui, N; Terui, K; Nagata, K; Japanese Congenital Diaphragmatic Hernia Study Grp

    PEDIATRIC RESEARCH   2025.1   ISSN:0031-3998 eISSN:1530-0447

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    Language:English   Publisher:Pediatric Research  

    Background: To retrospectively investigate the developmental outcomes at 3 years of age in patients with congenital diaphragmatic hernia (CDH) using a multicenter collaborative research approach. Methods: We evaluated patients with CDH and no other malformations born between 2010 and 2016 in seven facilities in the Japanese CDH Research Group. The developmental quotient (DQ) at 3 years of age was evaluated using the Kyoto Scale of Psychological Development 2001, the most standardized scale in Japan. Factors associated with a DQ score < 85 were also analyzed. Results: Of 196 patients, developmental assessments at 3 years of age were performed in 132 patients (67%). Among these, 99 patients (75%) had a DQ score ≥ 85, 25 (19%) had a DQ score between 70 and 84, and 8 (6%) had a DQ score < 70. Multivariate analysis showed that the observed/expected lung area-to-head circumference ratio was an independent predictor of a DQ score < 85, with an adjusted odds ratio of 0.62 (95% confidence interval: 0.40–0.96; p = 0.03). Conclusion: Generally, isolated CDH is associated with good developmental outcomes for survivors, even after intensive care. However, there is a risk of neurodevelopmental impairment if pulmonary hypoplasia is present. Impact: This research highlights the observed/expected lung area-to-head circumference ratio (o/e LHR) as a crucial indicator to predict neurodevelopmental outcomes in 3-year-old children diagnosed with isolated congenital diaphragmatic hernia (CDH). Our results provide robust evidence from a large multicenter cohort, emphasizing the importance of o/e LHR in early risk stratification and prolonged neurodevelopmental follow-up. These findings highlight the need for comprehensive management and tailored follow-up care in CDH patients, potentially improving clinical protocols and enhancing the quality of life and outcomes for affected children.

    DOI: 10.1038/s41390-025-03870-z

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  • HINODE study: haemophilia A in infancy and newborns - protocol for a prospective, multicentre, observational study evaluating the coagulation potential and safety of emicizumab prophylaxis

    Ohga, S; Takeyama, M; Ishimura, M; Inoue, H; Nosaka, D; Iwasaki, K; Mitsui, C; Nogami, K

    BMJ OPEN   14 ( 12 )   e087556   2024.12   ISSN:2044-6055

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    Language:English   Publisher:BMJ Open  

    Introduction Emicizumab prophylaxis is approved for people of all ages with haemophilia A (HA) including infants and children. Although previous studies have demonstrated the efficacy and tolerability of emicizumab in infants with HA, real-world data on emicizumab use in infants are limited. The Haemophilia A in Infancy and NewbOrns: multi-instituional prospective observational study to assess the efficacy anD safety of Emicizumab (HINODE) study aims to evaluate the coagulation potential and safety of emicizumab prophylaxis in infants with congenital HA from birth to <12 months of age. Methods and analysis This is a multicentre, observational study conducted in Japan in infants with congenital HA aged <12 months who are receiving or are scheduled to receive prophylactic emicizumab at an approved dosing regimen: 1.5 mg/kg weekly, 3 mg/kg every 2 weeks or 6 mg/kg every 4 weeks. The target inclusion is 50 infants. The primary endpoint is to evaluate the relationship between global coagulation test parameters (using clot waveform analysis and thrombin generation assay) and plasma emicizumab concentrations in infants aged from 6 to <12 months. Secondary endpoints include evaluating coagulation profiles in infants aged <6 months and changes between the age of <6 and 6 to <12 months. Additionally, coagulation parameters will be evaluated with the in vitro addition of anti-idiotype antibodies against emicizumab or the addition of a factor VIII product in infants aged from 6 to <12 months. The study will also evaluate adverse events and bleeds. Ethics and dissemination The study was approved by the MINS Clinical Trial Review Committee (no. 230214) and will be conducted in compliance with the Declaration of Helsinki, the Act on the Protection of Personal Information and the Guidance of Ethical Guidelines for Medical and Biological Research Involving Human Subjects. Written informed consent for participation in the study will be obtained from a legally acceptable representative. Results will be published in scientific/medical journals and presented at international congresses. Trial registration number Japan Registry of Clinical Trials; jRCT1031230264.

    DOI: 10.1136/bmjopen-2024-087556

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Presentations

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MISC

  • 【子どもの心と育ちを理解するツール】小児科医の目からみた遠城寺式乳幼児分析的発達検査の有用性と課題

    市山 正子, 川上 沙織, 井上 普介, 吉良 龍太郎, 酒井 康成, 大賀 正一

    教育と医学   72 ( 5 )   418 - 426   2024.9   ISSN:0452-9677

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    Language:Japanese   Publisher:慶應義塾大学出版会(株)  

  • Corrigendum to ‘Changing risk factors for postpartum depression in mothers admitted to a perinatal center’ [Pediatrics and Neonatology 64 (2023) 319–326, (S187595722200256X), (10.1016/j.pedneo.2022.09.013)]

    Sakemi Y., Nakashima T., Watanabe K., Ochiai M., Sawano T., Inoue H., Kawakami K., Isomura S., Yamashita H., Ohga S.

    Pediatrics and Neonatology   2024   ISSN:18759572

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    Language:English   Publisher:Pediatrics and Neonatology  

    This article [2023;64(3):319–326] titled “Changing risk factors for postpartum depression in mothers admitted to a perinatal center”, published in this journal, has a mistake. In 2.1. Study population: Line 7, “Fifty-seven mothers” should be corrected to “Forty-eight mothers”. In 3.1. Clinical features: Line 9, “The mean and standard deviation (SD)EPDS-J scores were 5.03 ± 0.12 within the first week and 3.79 ± 0.10 at the fourth week.” should be corrected to “The mean and standard deviation (SD)EPDS-J scores were 5.03 ± 4.45 within the first week and 3.79 ± 3.75 at the fourth week.” The authors apologize for this oversight. The authors would like to apologize for any inconvenience caused.

    DOI: 10.1016/j.pedneo.2024.08.002

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  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常 鉄過剰症 新生児鉄過剰症

    坂口 嘉彬, 井上 普介, 大賀 正一

    日本臨床   別冊 ( 血液症候群I )   512 - 516   2023.9   ISSN:0047-1852

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    Language:Japanese   Publisher:(株)日本臨床社  

  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常 貧血 その他の貧血 未熟児貧血

    隈本 大智, 井上 普介, 大賀 正一

    日本臨床   別冊 ( 血液症候群I )   415 - 419   2023.9   ISSN:0047-1852

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    Language:Japanese   Publisher:(株)日本臨床社  

  • 【周産期医療のヒヤリ・ハット-医療事故・医療紛争を防ぐために 新生児編】医療技術に関するもの 検体間違い

    井上 普介, 澤野 徹, 落合 正行

    周産期医学   53 ( 7 )   1106 - 1108   2023.7   ISSN:0386-9881

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    Language:Japanese   Publisher:(株)東京医学社  

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Professional Memberships

  • 日本小児科学会

  • 日本新生児成育医学会

  • 日本周産期新生児学会

  • 日本人類遺伝学会会

  • 日本小児神経学会

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Research Projects

  • ダウン症候群のTAMに合併する肝不全の発症と重症化の病態解明

    Grant number:24K11023  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    井上 普介, 古賀 友紀, 落合 正行

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    Grant type:Scientific research funding

    ダウン症候群児の約10%が出生時に一過性骨髄異常増殖症(transient abnormal myelopoiesis; TAM)を合併し、さらにそのうち約15%が乳児期早期死亡する。死亡原因の約半数は肝線維症による肝不全である。芽球数の多いTAMでは少量AraC治療にて死亡リスクが減少するが、芽球が少なくても肝不全を発症する例や、芽球が消失後にも肝不全が重症化する例があり、一度発症した肝不全に対しては有効な治療法は無い。申請者らは予備調査から、特定のケモカインが肝不全の発症と重症化に関与している可能性を見出したことから、TAMによる肝不全の発症と重症化の病態を解明して、予防と治療に介入可能な標的を絞り込む研究を行う。

    CiNii Research

  • 極低出生体重児が患う合併症に影響する血栓性素因の探索

    Grant number:22K07916  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    落合 正行, 井上 普介, 澤野 徹, 石村 匡崇, 藤吉 順子

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    Grant type:Scientific research funding

    未熟児動脈管開存症、頭蓋内出血・脳室周囲白質軟化、壊死性腸炎、未熟児網膜症および気管支肺異形成は、極低出生体重児の主要合併症であり、救命と予後に影響する。これらの病態には、血管新生と血栓傾向が関与する。血栓形成には環境要因と血栓性素因の影響を受けて複合的に作用する。研究代表者らは新生児期の血栓性素因を網羅的に検索する遺伝子パネル検査を試作し、診断未確定の血栓症新生児で測定したところ、過去に報告がない血管障害に関連する遺伝子変異を検出した。遺伝性血栓症には抗凝固療法や補充療法で治療可能な疾患が含まれる。本研究により合併症ハイリスクが早期診断され、遺伝子特異的な新規治療法の適応が期待できる。

    CiNii Research

  • 血管病変に着目した早産児気管支肺異形成症の病態解明

    Grant number:20K08231  2020 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    井上 普介, 藤吉 順子, 落合 正行

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    Authorship:Principal investigator  Grant type:Scientific research funding

    周産期医療の進歩により早産児の救命率は著しく改善したが、早産児の重要な呼吸器合併症
    である気管支肺異形成(bronchopulmonary dysplasia; BPD)は在胎28週未満の早産児では増加傾向である。研究代表者らの研究および既報では、妊娠週数に比較して低出生体重であるSGA(small-for-gestational age)児は出生前より血管病変を有し、またBPDの合併率も高いことが明らかとなった。本研究の目的は、BPDの発症や重症化に早産児の血管病変が関連し、血管病変がSGA児でBPD発症率が高い要因であるという、新しい仮説を検証することである。

    CiNii Research

  • Development of screening method for neonatal hereditary protein C deficiency and application to thrombotic disease

    Grant number:18K07849  2018 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ichiyama Masako

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    Grant type:Scientific research funding

    Most neonatal hereditary thrombosis is protein C deficiency. However, it is difficult to diagnose from the activity value in the neonatal period. In this study, we accumulated the clinical features and activity levels of 41 neonatal-onset protein C deficiencies with genetic testing (19 biallelic mutations, 9 monoallelic mutations, and 13 no mutations) . Moreover, a prediction formula for gene mutation detection was developed using the protein C activity value and the protein C/protein S activity ratio.
    In addition, a nationwide survey of neonatal thrombosis was conducted. Five of 9 patients with protein C gene mutations had monoallelic mutations, and the genetic effects of monoallelic mutations were recognized. Seventy-five percent of the patients developed within 3 days of age (including the fetal period) regardless of the presence or absence of the mutation, suggesting the importance of early diagnosis and early treatment.

    CiNii Research

  • 胎児子宮内発育遅延の病因病態に関する研究 -血管炎との関連について-

    Grant number:17K16300  2017 - 2020

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Educational Activities

  • 医学生に対しては、新生児医療における疾患、その診断と治療、および診断治療に用いる医療材料などに関する講義を担当している。また臨床実習に際しては、周産期新生児医療全般以外にも、チーム医療における医師の役割および基本的な診察手技について指導している。
    研修医に対しては、医師および社会人としての基本的態度、診療に必要な基本的知識および技術習得、学会・論文発表の指導を行っている。

Class subject

  • 総合医学I

    2018.4 - 2018.9   First semester

  • 総合医学I

    2017.4 - 2017.9   First semester

  • 受胎成長発達

    2016.4 - 2016.9   First semester

  • 総合医学I

    2016.4 - 2016.9   First semester

  • 受胎成長発達

    2015.4 - 2015.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • なし

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Pediatrics

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Fetal and Neonatal Medicine

Clinician qualification

  • Specialist

    Japan Pediatric Society

  • Specialist

    Japan Society of Perinatal and Neonatal Medicine

  • Specialist

    The Japan Society of Human Genetics

Year of medical license acquisition

  • 2003

Notable Clinical Activities

  • 2018年より総合周産期母子医療センター新生児内科部門の部門長およびリスクマネージャーとして、NICU・GCU病棟における診療、教育、医療安全の全般に携わっている。2022年からは小児科全体の運営管理、勤務管理、研究室管理を行っている。