Updated on 2024/10/01

Information

 

写真a

 
INOUE HIROSUKE
 
Organization
Kyushu University Hospital Pediatrics Lecturer
Kyushu University Hospital Pediatrics（Concurrent）
School of Medicine Department of Medicine（Concurrent）
Title
Lecturer
Contact information
メールアドレス
Tel
0926425421
Profile
小児科、特に周産期・新生児医療の診療・研究・教育を行っている。 診療では、当院総合周産期母子医療センターの新生児内科部門において、早産児および合併症を有する新生児に対する全身的集中治療を専門としている。また、出生前のケアおよび退院後のフォローアップも担当し、他科・多職種と連携しながら患児および家族に対し包括的なケアを提供している。 研究では、周産期・新生児医療を中心に基礎研究から臨床研究まで幅広く取り組んでおり、その成果を積極的に発表している。 教育では、医学生、大学院生、および研修医に対して、周産期・新生児医療に関する講義・診療指導・研究指導を行っている。
External link

Degree

  • Ph.D in Medicine

Research Interests・Research Keywords

  • Research theme：perinatal and neonatal medicine

    Keyword：neonate

    Research period： 2014.4 - 2015.9

Awards

  • 第70回九州小児科学会優秀英語論文

    2017.10   九州小児科学会  

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    Early Mortality and Morbidity in Infants with Birth Weight of 500 Grams or Less in Japan.

  • 第69回九州小児科学会優秀論文賞（英文）

    2016.11   九州小児科学会  

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    Activation of Nod1 signaling induces fetal growth restriction and death through fetal and maternal vasculopathy

Papers

  • Antiplatelets for Cardiovascular Disease in Non-valvular AF with Rivaroxaban: A Subanalysis of the EXPAND Study.

    Kaikita K, Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Fukuda K, Origasa H, Shimokawa H

    Journal of atherosclerosis and thrombosis   2024.9   （ ISSN:1340-3478 ）

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    Language：English  

    DOI： 10.5551/jat.64681

    PubMed

  • Prolonged exposure to hypergravity increases number and size of cells and enhances lignin deposition in the stem of <i>Arabidopsis thaliana</i>

    Shinohara, H; Muramoto, M; Tamaoki, D; Kamachi, H; Inoue, H; Kume, A; Karahara, I

    JOURNAL OF PLANT RESEARCH   137 ( 5 )   927 - 937   2024.9   （ ISSN:0918-9440 eISSN:1618-0860 ）

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  • Real-time information processing via volatile resistance change in scalable protonic devices

    Pati, SP; Geng, YF; Hamasuna, S; Fujiwara, K; Iizuka, T; Inoue, H; Inoue, I; Yajima, T

    COMMUNICATIONS MATERIALS   5 ( 1 )   2024.8   （ eISSN:2662-4443 ）

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  • Impact of surgical treatment on patient reported outcome in patients with spinal metastases from prostate cancer.

    Hirota R, Oshigiri T, Iesato N, Emori M, Teramoto A, Shiratani Y, Suzuki A, Terai H, Shimizu T, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funayama T, Miura K, Shirasawa E, Inoue H, Kimura A, Iimura T, Moridaira H, Nakajima H, Watanabe S, Akeda K, Takegami N, Nakanishi K, Sawada H, Matsumoto K, Funaba M, Suzuki H, Funao H, Hirai T, Otsuki B, Kobayakawa K, Uotani K, Manabe H, Tanishima S, Hashimoto K, Iwai C, Yamabe D, Hiyama A, Seki S, Goto Y, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nakashima H, Nagoshi N, Kato S, Imagama S, Watanabe K, Inoue G, Furuya T

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   2024.8   （ ISSN:0949-2658 ）

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    Language：English  

    DOI： 10.1016/j.jos.2024.07.012

    PubMed

  • Novel scale for evaluating the therapeutic efficacy of per-oral endoscopic myotomy in achalasia

    Takahashi, K; Sato, H; Shimamura, Y; Abe, H; Shiwaku, H; Shiota, J; Sato, C; Hamada, K; Ominami, M; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Terai, S; Inoue, H

    JOURNAL OF GASTROENTEROLOGY   59 ( 8 )   658 - 667   2024.8   （ ISSN:0944-1174 eISSN:1435-5922 ）

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  • Patient Outcomes in Very Elderly Patients With Non-Valvular Atrial Fibrillation ANAFIE Registry

    Suzuki, S; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Okumura, K; Koretsune, Y; Shimizu, W; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Morishima, Y; Fukuzawa, M; Takita, A; Inoue, H

    CIRCULATION REPORTS   6 ( 8 )   283 - 293   2024.8   （ eISSN:2434-0790 ）

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  • Safety and efficacy of ripasudil eye drops in preterm infants with retinopathy of prematurity: phase 1/2, open label, single-arm trial

    Arima, M; Inoue, H; Misumi, A; Tsukamoto, S; Matsushita, I; Araki, S; Ohta, M; Takahashi, K; Imazato, M; Goto, T; Aoki, Y; Tagawa, K; Hirose, M; Fujita, Y; Yoshida, N; Nakao, S; Kondo, H; Kusuhara, K; Kimura, K; Hasegawa, S; Ikeda, Y; Kodama, Y; Moritake, H; Ochiai, M; Ohga, S; Kishimoto, J; Todaka, K; Ieiri, I; Sonoda, KH

    JAPANESE JOURNAL OF OPHTHALMOLOGY   68 ( 5 )   490 - 499   2024.7   （ ISSN:0021-5155 eISSN:1613-2246 ）

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    Language：English   Publisher：Japanese Journal of Ophthalmology  

    Purpose: To assess the safety and efficacy of ripasudil for retinopathy of prematurity (ROP). Study design: Phase 1/2, multicenter, open-label, single-arm, 12-week clinical trial. Methods: Infants born with gestational age (GA) of ≤ 32 weeks or weight of ≤ 1500 g with zone I or II, ≥ stage 1, ROP in both eyes were enrolled. Ripasudil eye drops were administered to patients in both eyes. Phase 1 was a dose-escalation study (once daily for 1 week, then twice daily for 2 weeks); an additional dosing up to 9 weeks was allowed if no safety issues occurred. In phase 2, ripasudil was administered twice daily for up to 12 weeks. Adverse events were assessed. The proportion of patients with type 1 ROP progression, number of days for type 1 ROP progression, and progression to the most advanced ROP stage were estimated. Results: Twenty-four infants were enrolled (phase 1, n = 3; phase 2, n = 21). Nineteen and four patients experienced systemic and ocular adverse events, respectively. Efficacy endpoints were not different between the ripasudil and historical control groups. However, in the GA ≤ 27 weeks subgroup, fewer patients progressed to type 1 ROP in the ripasudil than in the historical control group (P = 0.09). In the GA ≤ 27 weeks subgroups, the 25th percentile for the number of days for type 1 ROP progression was 22 days in the historical control group and 44 days in the ripasudil group. Conclusion: Ripasudil was safe and inhibited/delayed type 1 ROP progression, especially in infants with short GA.

    DOI： 10.1007/s10384-024-01100-3

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  • Risks of dementia in a general Japanese older population with preserved ratio impaired spirometry: The Hisayama Study

    Kawatoko, K; Washio, Y; Ohara, T; Fukuyama, S; Honda, T; Hata, J; Nakazawa, T; Kan-o, K; Inoue, H; Matsumoto, K; Nakao, T; Kitazono, T; Okamoto, I; Ninomiya, T

    JOURNAL OF EPIDEMIOLOGY   34 ( 7 )   331 - 339   2024.7   （ ISSN:0917-5040 ）

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  • Echocardiographic Parameters of Left Atrial Structure and Function and Clinical Outcomes at 2 Years in Elderly Patients With Atrial Fibrillation ― The ANAFIE Echocardiographic Substudy ―

    Hiasa, KI; Kaku, H; Inoue, H; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Tsutsui, H

    CIRCULATION JOURNAL   88 ( 7 )   1155 - 1164   2024.7   （ ISSN:1346-9843 eISSN:1347-4820 ）

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  • Achalasia phenotypes and prediction of peroral endoscopic myotomy outcomes using machine learning

    Takahashi, K; Sato, H; Shimamura, Y; Abe, H; Shiwaku, H; Shiota, J; Sato, C; Hamada, K; Ominami, M; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Terai, S; Inoue, H

    DIGESTIVE ENDOSCOPY   36 ( 7 )   789 - 800   2024.7   （ ISSN:0915-5635 eISSN:1443-1661 ）

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  • Prospective Registration Study for Establishing Minimal Clinically Important Differences in Patients Undergoing Surgery for Spinal Metastases.

    Hirota R, Oshigiri T, Iesato N, Emori M, Teramoto A, Shiratani Y, Suzuki A, Terai H, Shimizu T, Kakutani K, Kanda Y, Tominaga H, Kawamura I, Ishihara M, Paku M, Takahashi Y, Funayama T, Miura K, Shirasawa E, Inoue H, Kimura A, Iimura T, Moridaira H, Nakajima H, Watanabe S, Akeda K, Takegami N, Nakanishi K, Sawada H, Matsumoto K, Funaba M, Suzuki H, Funao H, Hirai T, Otsuki B, Kobayakawa K, Uotani K, Manabe H, Tanishima S, Hashimoto K, Iwai C, Yamabe D, Hiyama A, Seki S, Goto Y, Miyazaki M, Watanabe K, Nakamae T, Kaito T, Nakashima H, Nagoshi N, Kato S, Imagama S, Watanabe K, Inoue G, Furuya T

    Spine   2024.6   （ ISSN:0362-2436 ）

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    Language：English  

    DOI： 10.1097/BRS.0000000000005062

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  • The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia

    Ikeda, H; Ihara, E; Takeya, K; Mukai, K; Onimaru, M; Ouchida, K; Hata, Y; Bai, XP; Tanaka, Y; Sasaki, T; Saito, F; Eto, M; Nakayama, J; Oda, Y; Nakamura, M; Inoue, H; Ogawa, Y

    JOURNAL OF GASTROENTEROLOGY   59 ( 5 )   361 - 375   2024.5   （ ISSN:0944-1174 eISSN:1435-5922 ）

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  • Gastrointestinal bleeding in elderly patients with atrial fibrillation: prespecified All Nippon Atrial Fibrillation in the Elderly (ANAFIE) Registry subgroup analysis

    Yamamoto, T; Mizokami, Y; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    SCIENTIFIC REPORTS   14 ( 1 )   9688   2024.4   （ ISSN:2045-2322 ）

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  • Clinical outcomes and anticoagulation therapy in elderly non-valvular atrial fibrillation and heart failure patients

    Ikeda, S; Hiasa, KI; Inoue, H; Yamashita, T; Akao, M; Atarashi, H; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Ikeda, T; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Tsutsui, H

    ESC HEART FAILURE   11 ( 2 )   902 - 913   2024.4   （ ISSN:2055-5822 ）

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  • Coronary events in elderly patients with non-valvular atrial fibrillation: a prespecified sub-analysis of the ANAFIE registry

    Nakamura, M; Inoue, H; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Yasaka, M; Yamaguchi, T; Teramukai, S; Morishima, Y; Fukuzawa, M; Takita, A; Hirayama, A

    CARDIOVASCULAR INTERVENTION AND THERAPEUTICS   39 ( 2 )   145 - 155   2024.4   （ ISSN:1868-4300 eISSN:1868-4297 ）

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  • Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity

    Bai, YF; Morita, K; Kokaji, T; Hatano, A; Ohno, S; Egami, R; Pan, YF; Li, DZ; Yugi, K; Uematsu, S; Inoue, H; Inaba, Y; Suzuki, Y; Matsumoto, M; Takahashi, M; Izumi, Y; Bamba, T; Hirayama, A; Soga, T; Kuroda, S

    ISCIENCE   27 ( 3 )   109121   2024.3   （ eISSN:2589-0042 ）

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  • Non-conditioned cord blood transplantation for infection control in athymic CHARGE syndrome. International journal

    Motoshi Sonoda, Masataka Ishimura, Hirosuke Inoue, Katsuhide Eguchi, Masayuki Ochiai, Yasunari Sakai, Takehiko Doi, Kyoko Suzuki, Takeshi Inoue, Tomoyuki Mizukami, Kimitoshi Nakamura, Hidetoshi Takada, Shouichi Ohga

    Pediatric blood & cancer   71 ( 3 )   e30809   2024.3   （ ISSN:1545-5009 eISSN:1545-5017 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: CHARGE syndrome is a congenital malformation syndrome caused by heterozygous mutations in the CHD7 gene. Severe combined immunodeficiency (SCID) arises from congenital athymia called CHARGE/complete DiGeorge syndrome. While cultured thymus tissue implantation (CTTI) provides an immunological cure, hematopoietic cell transplantation (HCT) is an alternative option for immuno-reconstitution of affected infants. We aimed to clarify the clinical outcomes of patients with athymic CHARGE syndrome after HCT. METHODS: We studied the immunological reconstitution and outcomes of four patients who received non-conditioned unrelated donor cord blood transplantation (CBT) at Kyushu University Hospital from 2007 to 2022. The posttransplant outcomes were compared with the outcomes of eight reported patients. RESULTS: Four index cases received CBT 70-144 days after birth and had no higher than grade II acute graft-versus-host disease. One infant was the first newborn-screened athymic case in Japan. They achieved more than 500/μL naïve T cells with balanced repertoire 1 month post transplant, and survived more than 12 months with home care. Twelve patients including the index cases received HCT at a median 106 days after birth (range: 70-195 days). One-year overall survival rate was significantly higher in patients who underwent non-conditioned HCT than in those who received conditioned HCT (100% vs. 37.5%, p = .02). Nine patients died, and the major cause of death was cardiopulmonary failure. CONCLUSIONS: Athymic infants achieved a prompt reconstitution of non-skewing naïve T cells after non-conditioned CBT that led to home care in infancy without significant infections. Non-conditioned CBT is a useful bridging therapy for newborn-screened cases toward an immunological cure by CTTI.

    DOI： 10.1002/pbc.30809

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  • An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy

    Qiu, YJ; Sajidah, ES; Kondo, S; Narimatsu, S; Sandira, MI; Higashiguchi, Y; Nishide, G; Taoka, A; Hazawa, M; Inaba, Y; Inoue, H; Matsushima, A; Okada, Y; Nakada, M; Ando, T; Lim, K; Wong, RW

    CELLS   13 ( 3 )   2024.2   （ eISSN:2073-4409 ）

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  • Single amino acid mutation of nectin-1 provides remarkable resistance against lethal pseudorabies virus infection in mice

    Tomioka, Y; Takeda, K; Ozaki, K; Inoue, H; Yamamoto, S; Takeuchi, T; Ono, E

    JOURNAL OF VETERINARY MEDICAL SCIENCE   86 ( 1 )   120 - 127   2024.1   （ ISSN:0916-7250 eISSN:1347-7439 ）

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  • Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering

    Ono, N; Kai, T; Takeyama, Y; Inoue, Y; Ueda, N; Nagano, S; Ohta, S; Inoue, H; Sawabe, T; Chifu, Y; Yoshizawa, S; Oryoji, K; Kimoto, Y; Miyake, K; Ayano, M; Mitoma, H; Arinobu, Y; Miyamura, T; Horiuchi, T; Akashi, K; Tada, Y; Niiro, H

    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES   27 ( 1 )   e15009   2024.1   （ ISSN:1756-1841 eISSN:1756-185X ）

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  • 電撃性紫斑病を契機に診断された新生児先天性プロテインC欠乏症 眼合併症の課題

    宮内 雄太, 園田 素史, 石村 匡崇, 江口 祥美, 江口 克秀, 原田 頌隆, 澤野 徹, 井上 普介, 落合 正行, 大賀 正一

    日本小児科学会雑誌   127 ( 12 )   1568 - 1568   2023.12   （ ISSN:0001-6543 ）

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    Language：Japanese   Publisher：(公社)日本小児科学会  

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  • The clinical and genetic landscape of early-onset thrombophilia in Japan. International journal

    Naoki Egami, Masataka Ishimura, Masayuki Ochiai, Masako Ichiyama, Hirosuke Inoue, Souichi Suenobu, Toshiya Nishikubo, Keiji Nogami, Akira Ishiguro, Taeko Hotta, Takeshi Uchiumi, Dongchon Kang, Shouichi Ohga

    Pediatric blood & cancer   71 ( 3 )   e30824   2023.12   （ ISSN:1545-5009 eISSN:1545-5017 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVES: To determine the optimal management for early-onset thrombophilia (EOT), the genetic and clinical features of protein C (PC)-, protein S (PS)-, or antithrombin (AT)-deficient patients of ≤20 years of age were studied in Japan. METHODS/RESULTS: Clinical and genetic information of all genetically diagnosed cases was collected through the prospective, retrospective study, and literature review. One-hundred-one patients had PC (n = 55), PS (n = 29), or AT deficiency (n = 18). One overlapping case had PC- and PS-monoallelic variant. Fifty-five PC-deficient patients (54%) had 26 monoallelic or 29 biallelic variant(s), and 29 (29%) PS-deficient patients had 20 monoallelic or nine biallelic variant(s). None of the patients had AT-biallelic variants. The frequent low-risk allele p.K193del (PC-Tottori) was found in five patients with monoallelic (19%) but not 29 with biallelic variant(s). The most common low-risk allele p.K196E (PS-Tokushima) was found in five with monoallelic (25%) and six with biallelic variant(s) (67%). One exceptional de novo PC variant was found in 32 families with EOT. Only five parents had a history of thromboembolism. Thrombosis concurrently developed in three mother-newborn pairs (two PC deficiency and one AT deficiency). The prospective cohort revealed the outcomes of 35 patients: three deaths with PC deficiency and 20 complication-free survivors. Neurological complications were more frequently found in patients with PC-biallelic variants than those with PC-, PS-, or AT-monoallelic variants (73% vs. 24%, p = .019). CONCLUSIONS: We demonstrate the need for elective screening for EOT targeting PC deficiency in Japan. Early prenatal diagnosis of PC deficiency in mother-infant pairs may prevent perinatal thrombosis in them.

    DOI： 10.1002/pbc.30824

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  • Relationship Between Direct Oral Anticoagulant Doses and Clinical Outcomes in Elderly Patients With Non-Valvular Atrial Fibrillation ― ANAFIE Registry Sub-Analysis ―

    Akao, M; Inoue, H; Yamashita, T; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Shimizu, W

    CIRCULATION JOURNAL   87 ( 12 )   1765 - 1774   2023.12   （ ISSN:1346-9843 eISSN:1347-4820 ）

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  • Anticoagulant therapy and home blood pressure-associated risk for stroke/bleeding events in elderly patients with non-valvular atrial fibrillation: the sub-cohort study of ANAFIE registry

    Kario, K; Hasebe, N; Okumura, K; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    HYPERTENSION RESEARCH   46 ( 12 )   2575 - 2582   2023.12   （ ISSN:0916-9636 eISSN:1348-4214 ）

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  • Effectiveness and safety of reduced-dose rivaroxaban for elderly patients with non-valvular atrial fibrillation: A subanalysis of the EXPAND study

    Shimizu, W; Uchiyama, S; Atarashi, H; Inoue, H; Kitazono, T; Yamashita, T; Ikeda, T; Kamouchi, M; Kaikita, K; Fukuda, K; Origasa, H; Shimokawa, H

    INTERNATIONAL JOURNAL OF CARDIOLOGY   391   131290   2023.11   （ ISSN:0167-5273 eISSN:1874-1754 ）

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  • Comprehension of Nonvalvular Atrial Fibrillation and Anticoagulant Adherence in Elderly Patients in a Subcohort Study of the All Nippon Atrial Fibrillation in the Elderly Registry (vol 204, pg 159, 2023)

    Akao, M; Yamashita, T; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    AMERICAN JOURNAL OF CARDIOLOGY   207   524   2023.11   （ ISSN:0002-9149 eISSN:1879-1913 ）

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  • Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023)

    Unoki, T; Hayashida, K; Kawai, Y; Taito, S; Ando, M; Iida, Y; Kasai, F; Kawasaki, T; Kozu, R; Kondo, Y; Saitoh, M; Sakuramoto, H; Sasaki, N; Saura, R; Nakamura, K; Ouchi, A; Okamoto, S; Okamura, M; Kuribara, T; Kuriyama, A; Matsuishi, Y; Yamamoto, N; Yoshihiro, S; Yasaka, T; Abe, R; Iitsuka, T; Inoue, H; Uchiyama, Y; Endo, S; Okura, K; Ota, K; Otsuka, T; Okada, D; Obata, K; Katayama, Y; Kaneda, N; Kitayama, M; Kina, S; Kusaba, R; Kuwabara, M; Sasanuma, N; Takahashi, M; Takayama, C; Tashiro, N; Tatsuno, J; Tamura, T; Tamoto, M; Tsuchiya, A; Tsutsumi, Y; Nagato, T; Narita, C; Nawa, T; Nonoyama, T; Hanada, M; Hirakawa, K; Makino, A; Masaki, H; Matsuki, R; Matsushima, S; Matsuda, W; Miyagishima, S; Moromizato, M; Yanagi, N; Yamauchi, K; Yamashita, Y; Yamamoto, N; Liu, KB; Wakabayashi, Y; Watanabe, S; Yonekura, H; Nakanishi, N; Takahashi, T; Nishida, O

    JOURNAL OF INTENSIVE CARE   11 ( 1 )   47   2023.11   （ ISSN:2052-0492 ）

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  • Impact of forest type and age on shallow landslide susceptibility: a case study from the 2017 heavy rainfall in northern Kyushu, Japan

    Nishioka, M; Inoue, H; Ota, T; Mizoue, N

    JOURNAL OF FOREST RESEARCH   28 ( 6 )   389 - 396   2023.11   （ ISSN:1341-6979 eISSN:1610-7403 ）

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  • Development of novel tryptophan-based antibody-drug conjugates for EGFR-expressing lung cancer

    Inoue, H; Oisaki, K; Tagawa, H; Igata, F; Nakao, A; Ebi, N; Mori, T; Fujita, M

    RESPIROLOGY   28   119 - 120   2023.11   （ ISSN:1323-7799 eISSN:1440-1843 ）

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  • Comprehension of Nonvalvular Atrial Fibrillation and Anticoagulant Adherence in Elderly Patients in a Subcohort Study of the All Nippon Atrial Fibrillation in the Elderly Registry

    Akao, M; Yamashita, T; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    AMERICAN JOURNAL OF CARDIOLOGY   204   159 - 167   2023.10   （ ISSN:0002-9149 eISSN:1879-1913 ）

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  • 新生児臨床研究ネットワークデータベースを用いた在胎週数別・性別気管支肺異形成プロファイル

    渡部 貴秀, 落合 正行, 江上 直樹, 井上 普介, 中西 秀彦, 平野 慎也, 楠田 聡

    日本新生児成育医学会雑誌   35 ( 3 )   554 - 554   2023.10   （ ISSN:2189-7549 ）

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  • 周産期因子で分類した気管支肺異形成予測式の開発 リスク別予防管理の可能性

    蛯原 郷, 江上 直樹, 松永 友佳, 澤野 徹, 井上 普介, 藤吉 順子, 落合 正行, 楠田 剛, 金城 唯宗

    日本新生児成育医学会雑誌   35 ( 3 )   547 - 547   2023.10   （ ISSN:2189-7549 ）

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  • Risk of both intracranial hemorrhage and ischemic stroke in elderly individuals with nonvalvular atrial fibrillation taking direct oral anticoagulants compared with warfarin: Analysis of the ANAFIE registry

    Shiozawa, M; Koga, M; Inoue, H; Yamashita, T; Yasaka, M; Suzuki, S; Akao, M; Atarashi, H; Ikeda, T; Okumura, K; Koretsune, Y; Shimizu, W; Tsutsui, H; Hirayama, A; Nakahara, J; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Yamaguchi, T; Toyoda, K

    INTERNATIONAL JOURNAL OF STROKE   18 ( 8 )   986 - 995   2023.10   （ ISSN:1747-4930 eISSN:1747-4949 ）

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  • Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models

    Matsukawa, T; Yagi, T; Uchida, T; Sakai, M; Mitsushima, M; Naganuma, T; Yano, H; Inaba, Y; Inoue, H; Yanagida, K; Uematsu, M; Nakao, K; Nakao, H; Aiba, A; Nagashima, Y; Kubota, T; Kubota, N; Izumida, Y; Yahagi, N; Unoki-Kubota, H; Kaburagi, Y; Asahara, SI; Kido, Y; Shindou, H; Itoh, M; Ogawa, Y; Minami, S; Terauchi, Y; Tobe, K; Ueki, K; Kasuga, M; Matsumoto, M

    JCI INSIGHT   8 ( 17 )   2023.9   （ eISSN:2379-3708 ）

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  • Critical diseases in neonates after discharge home from birth hospital: A retrospective study from a tertiary hospital in Japan. International journal

    Junko Fujiyoshi, Hirosuke Inoue, Toru Sawano, Yuichi Mushimoto, Yoshitomo Motomura, Kei Nishiyama, Noriyuki Kaku, Hazumu Nagata, Kenichiro Yamamura, Masataka Ishimura, Yuhki Koga, Masayuki Ochiai, Yasunari Sakai, Tatsuro Tajiri, Shouichi Ohga

    Early human development   186   105869 - 105869   2023.9   （ ISSN:0378-3782 eISSN:1872-6232 ）

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    INTRODUCTION: To establish actionable neonatal screening during the first month of life, we investigated critical diseases in seemingly healthy newborns discharged from birth hospitals. METHODS: This retrospective study enrolled previously healthy full-term infants who visited our hospital, a tertiary hospital in Japan, from home between 5 and 28 days after birth from 2009 to 2018. Infants with known perinatal or congenital diseases, positive newborn screening results, or accidental injuries were excluded. Data were collected from electronic medical records, including principal diagnosis, clinical details, and prognosis at 18 months of age. RESULTS: Ninety-seven (58 %) of 168 eligible neonates were admitted to the hospital, and 71 (42 %) were not. The median admission rate in patients with disease onset at ≤14 days after birth (80 %) was significantly higher than that in patients with disease onset at ≥15 days (42 %). Among 45 patients who received intensive medical care, 5 died and 10 developed neurodevelopmental sequelae. Four of 5 patients died by 100 days. Among 25 diseases treated in intensive care unit, 17 (68 %) diseases had a prevalence of <1 per 2000 live births. The commonly used diagnostic methods were imaging (n = 58, 35 %) and physical examination (n = 34, 20 %). CONCLUSION: Critical diseases due to rare and heterogeneous causes in ostensibly healthy newborns occurred predominantly in the first two weeks of life. Optimal newborn screening and health check-up protocols may benefit from the wide spectrum of life-threatening diseases occurring in home after birth.

    DOI： 10.1016/j.earlhumdev.2023.105869

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  • Divergent neurodevelopmental profiles of very-low-birth-weight infants. International journal

    Reina Ogata, Kyoko Watanabe, Pin Fee Chong, Jun Okamoto, Yoshihiro Sakemi, Toshinori Nakashima, Takuro Ohno, Hiroyuki Nomiyama, Yuri Sonoda, Yuko Ichimiya, Hirosuke Inoue, Masayuki Ochiai, Hironori Yamashita, Yasunari Sakai, Shouichi Ohga

    Pediatric research   95 ( 1 )   233 - 240   2023.8   （ ISSN:0031-3998 eISSN:1530-0447 ）

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    BACKGROUND: Advanced perinatal medicine has decreased the mortality rate of preterm infants. Long-term neurodevelopmental outcomes of very-low-birth-weight infants (VLBWIs) remain to be investigated. METHODS: Participants were 124 VLBWIs who had in-hospital birth from 2007 to 2015. Perinatal information, developmental or intelligence quotient (DQ/IQ), and neurological comorbidities at ages 3 and 6 years were analyzed. RESULTS: Fifty-eight (47%) VLBWIs received neurodevelopmental assessments at ages 3 and 6 years. Among them, 15 (26%) showed DQ/IQ <75 at age 6 years. From age 3 to 6 years, 21 (36%) patients showed a decrease (≤-10), while 5 (9%) showed an increase (≥+10) in DQ/IQ scores. Eight (17%) with autism spectrum disorder or attention-deficit hyperactivity disorder (ASD/ADHD) showed split courses of DQ/IQ, including two with ≤-10 and one with +31 to their scores. On the other hand, all 7 VLBWIs with cerebral palsy showed DQ ≤35 at these ages. Magnetic resonance imaging detected severe brain lesions in 7 (47%) of those with DQ <75 and 1 (18%) with ASD/ADHD. CONCLUSIONS: VLBWIs show a broad spectrum of neurodevelopmental outcomes after 6 years. These divergent profiles also indicate that different risks contribute to the development of ASD/ADHD from those of cerebral palsy and epilepsy in VLBWIs. IMPACT: Very-low-birth-weight infants (VLBWIs) show divergent neurodevelopmental outcomes from age 3 to 6 years. A deep longitudinal study depicts the dynamic change in neurodevelopmental profiles of VLBWIs from age 3 to 6 years. Perinatal brain injury is associated with developmental delay, cerebral palsy and epilepsy, but not with ASD or ADHD at age 6 years.

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  • Coagulation Biomarkers and Clinical Outcomes in Elderly Patients With Nonvalvular Atrial Fibrillation: ANAFIE Subcohort Study.

    Koretsune Y, Yamashita T, Akao M, Atarashi H, Ikeda T, Okumura K, Shimizu W, Suzuki S, Tsutsui H, Toyoda K, Hirayama A, Yasaka M, Yamaguchi T, Teramukai S, Kimura T, Morishima Y, Takita A, Inoue H

    JACC. Asia   3 ( 4 )   595 - 607   2023.8

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    DOI： 10.1016/j.jacasi.2023.06.004

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  • Impact of glycated hemoglobin on 2-year clinical outcomes in elderly patients with atrial fibrillation: sub-analysis of ANAFIE Registry, a large observational study

    Terauchi, Y; Inoue, H; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Shimizu, W

    CARDIOVASCULAR DIABETOLOGY   22 ( 1 )   175   2023.7   （ eISSN:1475-2840 ）

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  • 特集 周産期医療のヒヤリ･ハット-医療事故･医療紛争を防ぐために 新生児編 各論 医療技術に関するもの　検体間違い

    井上 普介, 澤野 徹, 落合 正行

    周産期医学   53 ( 7 )   1106 - 1108   2023.7   （ ISSN:03869881 ）

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    DOI： 10.24479/peri.0000001017

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  • 健常児として自宅退院した新生児に発症した重篤な疾患の検討

    藤吉 順子, 井上 普介, 澤野 徹, 虫本 雄一, 本村 良知, 賀来 典之, 永田 弾, 山村 健一郎, 石村 匡崇, 古賀 友紀, 落合 正行, 酒井 康成, 大賀 正一, 永田 公二, 田尻 達郎

    日本小児科学会雑誌   127 ( 7 )   1015 - 1015   2023.7

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  • 健常児として自宅退院した新生児に発症した重篤な疾患の検討

    藤吉 順子, 井上 普介, 澤野 徹, 虫本 雄一, 本村 良知, 賀来 典之, 永田 弾, 山村 健一郎, 石村 匡崇, 古賀 友紀, 落合 正行, 酒井 康成, 大賀 正一, 永田 公二, 田尻 達郎

    日本小児科学会雑誌   127 ( 7 )   1015 - 1015   2023.7   （ ISSN:0001-6543 ）

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  • 【周産期医療のヒヤリ・ハット-医療事故・医療紛争を防ぐために 新生児編】医療技術に関するもの 検体間違い

    井上 普介, 澤野 徹, 落合 正行

    周産期医学   53 ( 7 )   1106 - 1108   2023.7   （ ISSN:0386-9881 ）

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  • Impact of increased plasma levels of calreticulin on prognosis of patients with advanced lung cancer undergoing combination treatment of chemotherapy and immune checkpoint inhibitors

    Tsutsumi, H; Inoue, H; Shiraishi, Y; Hirayama, A; Nakanishi, T; Ando, H; Nakajima, M; Shinozaki, S; Ogata, H; Okamura, K; Kimura, S; Ogawa, T; Ota, K; Yoneshima, Y; Tanaka, K; Hamada, N; Okamoto, I; Iwama, E

    LUNG CANCER   181   107264   2023.7   （ ISSN:0169-5002 eISSN:1872-8332 ）

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  • Causes of Death in Elderly Patients With Non-Valvular Atrial Fibrillation-Results From the ANAFIE Registry

    Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    CIRCULATION JOURNAL   87 ( 7 )   957 - 963   2023.7   （ ISSN:1346-9843 eISSN:1347-4820 ）

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  • Effectiveness of umbilical culture for surveillance of methicillin-resistant Staphylococcus aureus among neonates admitted to neonatal intensive care units. International journal

    Toshinori Nakashima, Hirosuke Inoue, Yoshihiro Sakemi, Hironori Yamashita

    Infection control and hospital epidemiology   44 ( 6 )   988 - 990   2023.6   （ ISSN:0899-823X eISSN:1559-6834 ）

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    To compare the culture sensitivities of MRSA detection, we collected 988 paired umbilical and nasal cultures from screened neonates. MRSA positivity rates were 79.1% from umbilicus and 41.9% from nares (P = .01). The umbilicus was a more useful culture site than the nares for surveillance of MRSA among neonates upon admission.

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  • Renal Function and Clinical Outcomes Among Elderly Patients With Nonvalvular Atrial Fibrillation From ANAFIE.

    Shimizu W, Yamashita T, Akao M, Atarashi H, Ikeda T, Koretsune Y, Okumura K, Suzuki S, Tsutsui H, Toyoda K, Hirayama A, Yasaka M, Yamaguchi T, Teramukai S, Kimura T, Morishima Y, Takita A, Inoue H

    JACC. Asia   3 ( 3 )   475 - 487   2023.6

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    DOI： 10.1016/j.jacasi.2023.02.002

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  • 電撃性紫斑病を契機に診断された新生児先天性プロテインC欠乏症の女児例 眼合併症の課題

    宮内 雄太, 園田 素史, 石村 匡崇, 江口 祥美, 江口 克秀, 原田 頌隆, 澤野 徹, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   33 ( 1 )   S - 32   2023.5   （ ISSN:0916-8796 ）

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  • 超早産児の修正1歳半から修正3歳のDQスコア上昇には身長の伸びが関連する

    松永 友佳, 井上 普介, 落合 正行, チョン・ピンフィー, 酒井 康成, 大賀 正一

    脳と発達   55 ( Suppl. )   S329 - S329   2023.5   （ ISSN:0029-0831 eISSN:1884-7668 ）

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  • 極低出生体重児が6歳までに示す神経発達の変動 単一施設コホート

    緒方 怜奈, 安永 由紀恵, 渡辺 恭子, チョン・ピンフィー, 岡本 潤, 酒見 好弘, 中嶋 敏紀, 大野 拓郎, 園田 有里, 一宮 優子, 井上 普介, 落合 正行, 酒井 康成, 山下 博徳, 大賀 正一

    脳と発達   55 ( Suppl. )   S410 - S410   2023.5   （ ISSN:0029-0831 eISSN:1884-7668 ）

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  • Changing risk factors for postpartum depression in mothers admitted to a perinatal center. International journal

    Yoshihiro Sakemi, Toshinori Nakashima, Kyoko Watanabe, Masayuki Ochiai, Toru Sawano, Hirosuke Inoue, Kosuke Kawakami, Shuichi Isomura, Hironori Yamashita, Shouichi Ohga

    Pediatrics and neonatology   64 ( 3 )   319 - 326   2023.5   （ ISSN:1875-9572 eISSN:2212-1692 ）

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    BACKGROUND: The Edinburgh postnatal depression scale (EPDS) is commonly used in screening for major postpartum depression (PPD). We explored the clinical factors associated with score changes. METHODS: Mothers (n=1,287) who delivered a single live-born infant in Kokura Medical Center in Japan during 2018-2019 were analyzed. The EPDS-Japanese version was conducted at the first and fourth weeks after childbirth. Scores of ≥9 were considered to indicate an increased risk of PPD. RESULTS: The scores improved during the four-week period (5.03±0.12 to 3.79±0.10). Primiparity, Cesarean section (CS), and a low Apgar score were identified as initial risk factors, however, primiparity remained in the multivariate analysis (aOR 2.02, 95% CI 1.37-2.97). Age ≥35 years was associated with worsened scores (aOR 1.88, 95%CI 1.01-3.51), but CS improved (aOR 0.38, 95%CI 0.21-0.70). Primiparity, CS, and neonatal respiratory support were the initial risk factors, while infant anomaly was a late risk factor in mothers whose infants were admitted to the neonatal intensive care unit (NICU) (aOR 3.35, 95%CI 1.31-8.56). In mothers of infants with an NICU stay of ≥4 weeks, infant anomaly was associated with worsened scores (aOR 6.61, 95%CI 1.11-39.3), while respiratory support was associated with improved scores (aOR 0.09, 95%CI 0.01-0.65). Twenty-six mothrs with worsened scores received psychiatric support; three developed PPD. Two of the three were ≥35 years of age, neither of their infants had anomalies. CONCLUSION: Maternal aging and infant anomaly were risk factors for PPD. PPD occurred in mothers with worsened EPDS scores after mental care. Puerperants with worsening risk factors should be targeted to control PPD.

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  • 電撃性紫斑病を契機に診断された新生児先天性プロテインC欠乏症の女児例 眼合併症の課題

    宮内 雄太, 園田 素史, 石村 匡崇, 江口 祥美, 江口 克秀, 原田 頌隆, 澤野 徹, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   33 ( 1 )   S - 32   2023.5

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  • Prognostic impact of heart rate during atrial fibrillation on clinical outcomes in elderly non-valvular atrial fibrillation patients: ANAFIE Registry sub-cohort study

    Ikeda, T; Yamashita, T; Akao, M; Atarashi, H; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    JOURNAL OF CARDIOLOGY   81 ( 5 )   441 - 449   2023.5   （ ISSN:0914-5087 eISSN:1876-4738 ）

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  • Stroke in a protein C-deficient infant after stem cell transplant for CHARGE syndrome. International journal

    Atsushi Tanaka, Yoshiaki Sakaguchi, Hirosuke Inoue, Naoki Egami, Yuri Sonoda, Motoshi Sonoda, Masataka Ishimura, Masayuki Ochiai, Taeko Hotta, Takeshi Uchiumi, Yasunari Sakai, Shouichi Ohga

    Pediatric blood & cancer   70 ( 4 )   e30047   2023.4   （ ISSN:1545-5009 eISSN:1545-5017 ）

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  • Sim, a new human platelet antigen located on glycoprotein IIIa, identified in a case of fetal-neonatal alloimmune thrombocytopenia in Japan. International journal

    Yukari Kuroda, Toru Miyazaki, Nelson Hirokazu Tsuno, Hirosuke Inoue, Shouichi Ohga, Kazuo Irita

    Transfusion   63 ( 4 )   E17-E19 - E19   2023.4   （ ISSN:0041-1132 eISSN:1537-2995 ）

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    DOI： 10.1111/trf.17255

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  • 「大容量情報時代における新生児臨床研究ネットワーク(NRNJ)の役割～さらなる新生児研究の発展を目指して～」 NRNJを通じた人材育成

    落合 正行, 井上 普介, 安岡 和昭, 渡部 貴秀, 松下 悠紀, 中嶋 敏紀, 倉田 浩昭

    日本周産期・新生児医学会雑誌   58 ( 4 )   808 - 809   2023.4   （ ISSN:1348-964X eISSN:2435-4996 ）

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  • Impact of peroral endoscopic myotomy on high-resolution manometry findings and their association with the procedure's outcomes

    Hata, Y; Sato, H; Shimamura, Y; Abe, H; Shiwaku, A; Shiota, J; Sato, C; Ominami, M; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Ihara, E; Inoue, H

    GASTROINTESTINAL ENDOSCOPY   97 ( 4 )   673 - +   2023.4   （ ISSN:0016-5107 eISSN:1097-6779 ）

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  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 2 )   51 - 58   2023.3   （ ISSN:0916-8796 ）

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    新生児期の血栓症は希少な事例と考えられてきたが、医療の高度化と疾患認識の広がりにより報告数が増加している。さらに、日本人小児の血栓性素因における遺伝性プロテインC欠乏症の重要性が示されてきた。今回私たちは新生児血栓症の全国調査を行い、遺伝性プロテインC欠乏症の遺伝学的効果と、遺伝学的検査の悉皆性を示すことができた。今後は調査対象を小児から成人に達するまでに拡大し、小児患者とその家族を血栓症から守る個別化医療の確立を目指す。(著者抄録)

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  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 2 )   51 - 58   2023.3

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    新生児期の血栓症は希少な事例と考えられてきたが、医療の高度化と疾患認識の広がりにより報告数が増加している。さらに、日本人小児の血栓性素因における遺伝性プロテインC欠乏症の重要性が示されてきた。今回私たちは新生児血栓症の全国調査を行い、遺伝性プロテインC欠乏症の遺伝学的効果と、遺伝学的検査の悉皆性を示すことができた。今後は調査対象を小児から成人に達するまでに拡大し、小児患者とその家族を血栓症から守る個別化医療の確立を目指す。(著者抄録)

  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 2 )   51 - 58   2023.3

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    新生児期の血栓症は希少な事例と考えられてきたが、医療の高度化と疾患認識の広がりにより報告数が増加している。さらに、日本人小児の血栓性素因における遺伝性プロテインC欠乏症の重要性が示されてきた。今回私たちは新生児血栓症の全国調査を行い、遺伝性プロテインC欠乏症の遺伝学的効果と、遺伝学的検査の悉皆性を示すことができた。今後は調査対象を小児から成人に達するまでに拡大し、小児患者とその家族を血栓症から守る個別化医療の確立を目指す。(著者抄録)

  • 先天性横隔膜ヘルニア(congenital diaphragmatic hernia;CDH)児の3歳時発達予後

    澤野 徹, 井上 普介, 落合 正行, 酒井 康成, 大賀 正一, 藤田 恭之, 加藤 聖子, 近藤 琢也, 永田 公二, 田尻 達郎

    日本小児科学会雑誌   127 ( 3 )   470 - 470   2023.3   （ ISSN:0001-6543 ）

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  • Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case-control study

    Abe, H; Tanaka, S; Sato, H; Shimamura, Y; Okada, H; Shiota, J; Sato, C; Sakae, H; Ominami, M; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Inoue, H

    ENDOSCOPY   55 ( 3 )   217 - 224   2023.3   （ ISSN:0013-726X eISSN:1438-8812 ）

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  • Immunostimulatory oncolytic activity of coxsackievirus A11 in human malignant pleural mesothelioma

    Okamura, K; Inoue, H; Tanaka, K; Ikematsu, Y; Furukawa, R; Ota, K; Yoneshima, Y; Iwama, E; Okamoto, I

    CANCER SCIENCE   114 ( 3 )   1095 - 1107   2023.3   （ ISSN:1347-9032 eISSN:1349-7006 ）

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  • CMOS-based area-and-power-efficient neuron and synapse circuits for time-domain analog spiking neural networks

    Chen, XY; Byambadorj, Z; Yajima, T; Inoue, H; Inoue, IH; Iizuka, T

    APPLIED PHYSICS LETTERS   122 ( 7 )   2023.2   （ ISSN:0003-6951 eISSN:1077-3118 ）

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  • Clinical phenotypes of older adults with non-valvular atrial fibrillation not treated with oral anticoagulants by hierarchical cluster analysis in the ANAFIE Registry

    Suzuki, S; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Okumura, K; Koretsune, Y; Shimizu, W; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    PLOS ONE   18 ( 2 )   e0280753   2023.2   （ ISSN:1932-6203 ）

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  • 新生児健診のこれから-2021 大学病院へ緊急受診を要した新生児の基礎疾患

    落合 正行, 藤吉 順子, 井上 普介, 澤野 徹, 虫本 雄一, 本村 良和, 賀来 典之, 永田 弾, 山村 健一郎, 石村 匡崇, 古賀 友紀, 酒井 康成, 大賀 正一

    日本小児科学会雑誌   127 ( 2 )   170 - 170   2023.2   （ ISSN:0001-6543 ）

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  • A preterm newborn-onset juvenile myelomonocytic leukemia-like myeloproliferation with PTPN11 mutation. International journal

    Shunsuke Yamamoto, Shingo Nakao, Hirosuke Inoue, Yuhki Koga, Kanako Kojima-Ishii, Yuichiro Semba, Takahiro Maeda, Koichi Akashi, Shouichi Ohga

    Pediatric blood & cancer   70 ( 2 )   e29915   2023.2   （ ISSN:1545-5009 eISSN:1545-5017 ）

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  • Chemotherapeutic agents and the EGFR-TKI osimertinib provoke calreticulin exposure in non-small cell lung cancer

    Inoue, H; Furukawa, R; Yoneshima, Y; Tsutsumi, H; Iwama, E; Ikematsu, Y; Ando, N; Shiraishi, Y; Ota, K; Tanaka, K; Okamoto, I

    RESPIROLOGY   28   305 - 305   2023.2   （ ISSN:1323-7799 eISSN:1440-1843 ）

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  • CVA11 infection exerts potent immunogenic oncolytic activity in human malignant pleural mesothelioma via ICAM-1 receptor

    Okamura, K; Inoue, H; Tanaka, K; Ikematsu, Y; Furukawa, R; Ota, K; Yoneshima, Y; Iwama, E; Okamoto, I

    RESPIROLOGY   28   24 - 25   2023.2   （ ISSN:1323-7799 eISSN:1440-1843 ）

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  • Mutant forms of EGFR promote HER2 trafficking through efficient formation of HER2-EGFR heterodimers

    Tsutsumi, H; Iwama, E; Ibusuki, R; Shimauchi, A; Ota, K; Yoneshima, Y; Inoue, H; Tanaka, K; Nakanishi, Y; Okamoto, I

    LUNG CANCER   175   101 - 111   2023.1   （ ISSN:0169-5002 eISSN:1872-8332 ）

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  • Effect of Polypharmacy on Clinical Outcomes in Elderly Patients With Non-Valvular Atrial Fibrillation

    Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    CIRCULATION JOURNAL   87 ( 1 )   6 - +   2023.1   （ ISSN:1346-9843 eISSN:1347-4820 ）

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  • Impact of cognitive impairment on clinical outcomes in elderly patients with atrial fibrillation: ANAFIE Registry

    Nagata, K; Inoue, H; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Yasaka, M

    BMJ NEUROLOGY OPEN   5 ( 1 )   e000370   2023.1   （ eISSN:2632-6140 ）

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  • Effect of low body mass index on clinical recovery after fusion surgery for osteoporotic vertebral fracture: A retrospective, multicenter study of 237 cases

    Inoue, G; Miyagi, M; Saito, W; Shirasawa, E; Uchida, K; Hosogane, N; Watanabe, K; Katsumi, K; Kaito, T; Yamashita, T; Fujiwara, H; Nagamoto, Y; Nojiri, K; Suzuki, S; Okada, E; Ueda, S; Hikata, T; Shiono, Y; Watanabe, K; Terai, H; Tamai, K; Matsuoka, Y; Suzuki, H; Nishimura, H; Tagami, A; Yamada, S; Adachi, S; Ohtori, S; Furuya, T; Orita, S; Inage, K; Yoshii, T; Ushio, S; Funao, H; Isogai, N; Harimaya, K; Okada, S; Kawaguchi, K; Yokoyama, N; Oishi, H; Doi, T; Kiyasu, K; Imagama, S; Ando, K; Kobayashi, K; Sakai, D; Tanaka, M; Kimura, A; Inoue, H; Nakano, A; Ikegami, S; Shimizu, M; Futatsugi, T; Kakutani, K; Yurube, T; Nakanishi, K; Oshima, M; Uei, H; Aoki, Y; Takahata, M; Iwata, A; Endo, H; Seki, S; Murakami, H; Kato, S; Yoshioka, K; Hongo, M; Abe, T; Tsukanishi, T; Takaso, M; Ishii, K

    MEDICINE   101 ( 52 )   e32330   2022.12   （ ISSN:0025-7974 eISSN:1536-5964 ）

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  • Clinical outcomes of pulmonary agenesis: A systematic review of the literature. International journal

    Shoji Fukuoka, Kenichiro Yamamura, Hazumu Nagata, Daisuke Toyomura, Yusaku Nagatomo, Yoshimi Eguchi, Kiyoshi Uike, Yuichiro Hirata, Hirosuke Inoue, Masayuki Ochiai, Shouichi Ohga

    Pediatric pulmonology   57 ( 12 )   3060 - 3068   2022.12   （ ISSN:8755-6863 eISSN:1099-0496 ）

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    INTRODUCTION: Pulmonary agenesis is a complete absence of the pulmonary parenchyma, airways, and vasculature unilaterally or bilaterally. Although bilateral cases are lethal, the outcome of unilateral cases remains not well described. We performed a comprehensive literature review to assess the clinical features of pulmonary agenesis. METHODS: Four database sources were searched on October 10, 2021 and two cases were included from our institution. Studies related to the clinical impact of comorbidity and intervention on the survival outcome in pulmonary agenesis were included for full-text review. RESULTS: We identified 259 patients-with right-sided (59%), left-sided (34%), and bilateral agenesis (7%)-among 195 articles and our two cases. Additional anomalies included cardiovascular (40%), skeletal (30%), gastrointestinal (20%), tracheal (20%: all stenoses), and genitourinary (14%) anomalies. Fifty-seven (24%) individuals in unilateral pulmonary agenesis had isolated disease. Outcomes related to survival were not uniformly reported, but the 2-year overall survival rate of unilateral agenesis was 62% and no subsequent death was reported until 13 years of age. The right-sided agenesis was more frequently associated with tracheal stenosis (27% vs. 11%, p = 0.003) than the left-sided disease. A multivariable analysis indicated that tracheal stenosis (hazard ratio [HR]: 2.2, 95% confidence interval [CI]: 1.3-4.1, p = 0.003) and gastrointestinal anomalies (HR: 2.0, 95% CI: 1.1-3.3, p = 0.010) were prognostic factors for mortality. CONCLUSIONS: The poor prognostic factors were tracheal stenosis, right agenesis, and gastrointestinal anomalies. Treatment for these comorbidities is a key point for improving the survival of unilateral pulmonary agenesis.

    DOI： 10.1002/ppul.26135

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  • JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias

    Ono, K; Iwasaki, YK; Akao, M; Ikeda, T; Ishii, K; Inden, Y; Kusano, K; Kobayashi, Y; Koretsune, Y; Sasano, T; Sumitomo, N; Takahashi, N; Niwano, S; Hagiwara, N; Hisatome, I; Furukawa, T; Honjo, H; Maruyama, T; Murakawa, Y; Yasaka, M; Watanabe, E; Aiba, T; Amino, M; Itoh, H; Ogawa, H; Okumura, Y; Aoki-Kamiya, C; Kishihara, J; Kodani, E; Komatsu, T; Sakamoto, Y; Satomi, K; Shiga, T; Shinohara, T; Suzuki, A; Suzuki, S; Sekiguchi, Y; Nagase, S; Hayami, N; Harada, M; Fujino, T; Makiyama, T; Maruyama, M; Miake, J; Muraji, S; Murata, H; Morita, N; Yokoshiki, H; Yoshioka, K; Yodogawa, K; Inoue, H; Okumura, K; Kimura, T; Tsutsui, H; Shimizu, W

    JOURNAL OF ARRHYTHMIA   38 ( 6 )   833 - 973   2022.12   （ ISSN:1880-4276 eISSN:1883-2148 ）

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  • Home Blood Pressure Can Predict the Risk for Stroke/Bleeding Events in Elderly Patients With Nonvalvular Atrial Fibrillation From the ANAFIE Registry

    Kario, K; Hasebe, N; Okumura, K; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Shimizu, W; Suzuki, S; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Inoue, H

    HYPERTENSION   79 ( 12 )   2696 - 2705   2022.12   （ ISSN:0194-911X eISSN:1524-4563 ）

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  • Oral Anticoagulants in Very Elderly Nonvalvular Atrial Fibrillation Patients With High Bleeding Risks: ANAFIE Registry.

    Okumura K, Yamashita T, Akao M, Atarashi H, Ikeda T, Koretsune Y, Shimizu W, Suzuki S, Tsutsui H, Toyoda K, Hirayama A, Yasaka M, Yamaguchi T, Teramukai S, Kimura T, Morishima Y, Takita A, Inoue H

    JACC. Asia   2 ( 6 )   720 - 733   2022.11

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    DOI： 10.1016/j.jacasi.2022.07.008

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  • JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias

    Ono, K; Iwasaki, YK; Akao, M; Ikeda, T; Ishii, K; Inden, Y; Kusano, K; Kobayashi, Y; Koretsune, Y; Sasano, T; Sumitomo, N; Takahashi, N; Niwano, S; Hagiwara, N; Hisatome, I; Furukawa, T; Honjo, H; Maruyama, T; Murakawa, Y; Yasaka, M; Watanabe, E; Aiba, T; Amino, M; Itoh, H; Ogawa, H; Okumura, Y; Aoki-Kamiya, C; Kishihara, J; Kodani, E; Komatsu, T; Sakamoto, Y; Satomi, K; Shiga, T; Shinohara, T; Suzuki, A; Suzuki, S; Sekiguchi, Y; Nagase, S; Hayami, N; Harada, M; Fujino, T; Makiyama, T; Maruyama, M; Miake, J; Muraji, S; Murata, H; Morita, N; Yokoshiki, H; Yoshioka, K; Yodogawa, K; Inoue, H; Okumura, K; Kimura, T; Tsutsui, H; Shimizu, W

    CIRCULATION JOURNAL   86 ( 11 )   1790 - 1924   2022.11   （ ISSN:1346-9843 eISSN:1347-4820 ）

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  • Efficacy of peroral endoscopic myotomy for esophageal motility disorders after gastric surgery: Japan Achalasia Multicenter Study

    Nakamura, J; Sato, H; Onimaru, M; Abe, H; Shiwaku, H; Shiota, J; Sato, C; Sakae, H; Ominami, M; Hata, Y; Fukuda, H; Ogawa, R; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Takuto, H; Inoue, H

    DIGESTIVE ENDOSCOPY   34 ( 7 )   1394 - 1402   2022.11   （ ISSN:0915-5635 eISSN:1443-1661 ）

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  • A PRETERM-ONSET JUVENILE MYELOMONOCYTIC LEUKEMIA-LIKE MYELOPROLIFERATION WITH PTPN11 MUTATION

    Yamamoto, S; Nakao, S; Koga, Y; Inoue, H; Nakashima, K; Ishii, K; Semba, Y; Maeda, T; Akashi, K; Ohga, S

    PEDIATRIC BLOOD & CANCER   69   2022.11   （ ISSN:1545-5009 eISSN:1545-5017 ）

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  • 超早産児における修正1歳半時から修正3歳時の発達指数の変化に関わる因子の検討

    松永 友佳, 井上 普介, 澤野 徹, 藤吉 順子, 岩山 真理子, 落合 正行, 大賀 正一

    日本新生児成育医学会雑誌   34 ( 3 )   468 - 468   2022.10   （ ISSN:2189-7549 ）

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  • 胎児期の鉛曝露と小児期早期の神経発達 子どもの健康と環境に関する全国調査(エコチル調査)

    井上 普介, 實藤 雅文, 園田 有里, 小川 昌宣, 濱田 律雄, 下野 昌幸, 菅 礼子, 中山 祥嗣, 谷口 優, 楠原 浩一, 大賀 正一, 上島 通浩

    日本新生児成育医学会雑誌   34 ( 3 )   409 - 409   2022.10   （ ISSN:2189-7549 ）

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  • 胎児期の鉛曝露と小児期早期の神経発達 子どもの健康と環境に関する全国調査(エコチル調査)

    井上 普介, 實藤 雅文, 園田 有里, 小川 昌宣, 濱田 律雄, 下野 昌幸, 菅 礼子, 中山 祥嗣, 谷口 優, 楠原 浩一, 大賀 正一, 上島 通浩

    日本新生児成育医学会雑誌   34 ( 3 )   409 - 409   2022.10

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  • Risks of refractory chest pain after peroral endoscopic myotomy in achalasia-related esophageal motility disorders: short-term results from a multicenter study in Japan

    Fukuda, H; Sato, H; Fujiyoshi, Y; Abe, H; Okada, H; Shiota, J; Sato, C; Sakae, H; Ominami, M; Hata, Y; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Yamamoto, H; Inoue, H

    GASTROINTESTINAL ENDOSCOPY   96 ( 4 )   620 - +   2022.10   （ ISSN:0016-5107 eISSN:1097-6779 ）

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  • Subtype of Achalasia and Integrated Relaxation Pressure Measured Using the Starlet High-resolution Manometry System: A Multicenter Study in Japan

    Tatsuta, T; Sato, H; Fujiyoshi, Y; Abe, H; Shiwaku, A; Shiota, J; Sato, C; Ominami, M; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Ikebuchi, Y; Yokomichi, H; Fukuda, S; Inoue, H

    JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY   28 ( 4 )   562 - 571   2022.10   （ ISSN:2093-0879 eISSN:2093-0887 ）

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  • Prospective observational study in elderly patients with non-valvular atrial fibrillation: Rationale and design of the All Nippon AF In the Elderly (ANAFIE) Registry (vol 72, pg 300, 2018)

    Inoue, H; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Okumura, K; Koretsune, Y; Shimizu, W; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Akishita, M; Hasebe, N; Kario, K; Mizokami, Y; Nagata, K; Nakamura, M; Terauchi, Y; Yamamoto, T; Teramukai, S; Kimura, T; Kaburagi, J; Takita, A

    JOURNAL OF CARDIOLOGY   80 ( 4 )   375 - 376   2022.10   （ ISSN:0914-5087 eISSN:1876-4738 ）

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  • Frailty screening index and atrial fibrillation outcomes in the All Nippon AF In the Elderly registry

    Akishita, M; Suzuki, S; Inoue, H; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Yamashita, T

    GERIATRICS & GERONTOLOGY INTERNATIONAL   22 ( 10 )   899 - 902   2022.10   （ ISSN:1444-1586 eISSN:1447-0594 ）

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  • Risks of Mortality and Airflow Limitation in Japanese Individuals with Preserved Ratio Impaired Spirometry

    Washio, Y; Sakata, S; Fukuyama, S; Honda, T; Kan-O, K; Shibata, M; Hata, J; Inoue, H; Kitazono, T; Matsumoto, K; Ninomiya, T

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   206 ( 5 )   563 - 572   2022.9   （ ISSN:1073-449X eISSN:1535-4970 ）

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  • No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children's Study. International journal

    Hirosuke Inoue, Masafumi Sanefuji, Yuri Sonoda, Masanobu Ogawa, Norio Hamada, Masayuki Shimono, Reiko Suga, Shoji F Nakayama, Yu Taniguchi, Koichi Kusuhara, Shouichi Ohga, Michihiro Kamijima

    Scientific reports   12 ( 1 )   15305 - 15305   2022.9   （ ISSN:2045-2322 ）

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    Compared with the relatively well-investigated effects of childhood exposure to lead on neurocognitive deficits, those of prenatal exposure remain relatively inconclusive. We aimed to investigate the association between prenatal blood lead levels and neurodevelopmental delay during the first three years of life. From a prospective cohort of the Japan Environment and Children's Study, we analyzed a total of 80,759 children. The exposure factors were prenatal lead concentrations measured from maternal whole blood in the second/third trimesters and umbilical cord blood at birth. Neurodevelopment was assessed at 6, 12, 18, 24, 30, and 36 months old using a screening tool, the Ages and Stages Questionnaires, third edition (ASQ). The outcome measures were any suspected neurodevelopmental delay (sNDD) identified via the ASQ during the first (sNDD-1Y), second (sNDD-2Y), and third (sNDD-3Y) years of life. sNDD-1Y, 2Y, and 3Y were identified in 18.0%, 16.2%, and 17.2% of children, respectively. The geometric means of blood lead concentration in this study were much lower (0.62 μg/dL in maternal blood and 0.50 μg/dL in cord blood) than previously investigated levels. Multivariable regression models revealed that there were no associations between maternal blood lead and sNDD-1Y and 2Y and between cord blood lead and sNDD-1Y, 2Y, and 3Y. Although a higher maternal blood lead was associated with a reduced risk of sNDD-3Y (adjusted relative risk: 0.84, 95% confidence interval 0.75-0.94, per 1 increase in common logarithm of lead concentration), there were no dose-response relationships in the analysis using quintiles of lead concentrations. Using a large-scale data set, the present study demonstrated no convincing evidence for an inverse association between levels of prenatal blood lead and neurodevelopment in early childhood. Longitudinal measurements of prenatal and postnatal lead levels are needed to understand the relationship between lead exposure and neurocognitive development.

    DOI： 10.1038/s41598-022-19509-6

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  • Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan

    Shiwaku, H; Sato, H; Shimamura, Y; Abe, H; Shiota, J; Sato, C; Ominami, M; Sakae, H; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Hasegawa, S; Inoue, H

    ENDOSCOPY   54 ( 09 )   839 - 847   2022.9   （ ISSN:0013-726X eISSN:1438-8812 ）

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  • Precipitation behavior of iron and silicic acid when mixing acidic and weakly alkaline geothermal waters at the Hatchobaru geothermal power plant, Oita, Japan

    Juhri, S; Yonezu, K; Inoue, H; Kiyota, Y; Ohshima, S; Uemura, H; Uchiyama, N; Ueda, A; Yokoyama, T

    GEOTHERMICS   104   2022.9   （ ISSN:0375-6505 eISSN:1879-3576 ）

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  • Low-dose EGFR-TKIs Directly Induce Maturation and Functional Activity of Human Dendritic Cells in an EGFR-independent manner

    Inoue, H; Tsutsumi, H; Okamura, K; Ota, K; Yoneshima, Y; Iwama, E; Tanaka, K; Okamoto, I

    JOURNAL OF THORACIC ONCOLOGY   17 ( 9 )   S354 - S354   2022.9   （ ISSN:1556-0864 eISSN:1556-1380 ）

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  • Correction: Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan.

    Shiwaku H, Sato H, Shimamura Y, Abe H, Shiota J, Sato C, Ominami M, Sakae H, Hata Y, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Hasegawa S, Inoue H

    Endoscopy   54 ( 9 )   C13   2022.9   （ ISSN:0013-726X ）

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    DOI： 10.1055/a-1778-9730

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  • In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

    Kokaji, T; Eto, M; Hatano, A; Yugi, K; Morita, K; Ohno, S; Fujii, M; Hironaka, K; Ito, Y; Egami, R; Uematsu, S; Terakawa, A; Pan, YF; Maehara, H; Li, DZ; Bai, YF; Tsuchiya, T; Ozaki, H; Inoue, H; Kubota, H; Suzuki, Y; Hirayama, A; Soga, T; Kuroda, S

    SCIENTIFIC REPORTS   12 ( 1 )   13719   2022.8   （ ISSN:2045-2322 ）

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  • Impact of Previous Stroke on Clinical Outcome in Elderly Patients With Nonvalvular Atrial Fibrillation: ANAFIE Registry

    Yoshimoto, T; Toyoda, K; Ihara, M; Inoue, H; Yamashita, T; Suzuki, S; Akao, M; Atarashi, H; Ikeda, T; Okumura, K; Koretsune, Y; Shimizu, W; Tsutsui, H; Hirayama, A; Yasaka, M; Maruyama, H; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Yamaguchi, T

    STROKE   53 ( 8 )   2549 - 2558   2022.8   （ ISSN:0039-2499 eISSN:1524-4628 ）

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  • 左心低形成症候群、完全型DiGeorge症候群、およびプロテインC欠乏症を合併したCHARGE症候群

    坂口 嘉彬, 田中 惇史, 園田 素史, 井上 普介, 石村 匡崇, 永田 弾, 落合 正行, 酒井 康成, 大賀 正一

    日本小児科学会雑誌   126 ( 7 )   1087 - 1087   2022.7   （ ISSN:0001-6543 ）

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  • 左心低形成症候群、完全型DiGeorge症候群、およびプロテインC欠乏症を合併したCHARGE症候群

    坂口 嘉彬, 田中 惇史, 園田 素史, 井上 普介, 石村 匡崇, 永田 弾, 落合 正行, 酒井 康成, 大賀 正一

    日本小児科学会雑誌   126 ( 7 )   1087 - 1087   2022.7

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  • Lung to thorax transverse area ratio as a predictor of neurodevelopmental outcomes in fetuses with congenital diaphragmatic hernia. International journal

    Toru Sawano, Takuya Kondo, Go Ebihara, Kouji Nagata, Hirosuke Inoue, Junko Fujiyoshi, Masayuki Ochiai, Saki Kido, Yasuyuki Fujita, Yasunari Sakai, Kiyoko Kato, Tatsuro Tajiri, Shouichi Ohga

    Early human development   170   105598 - 105598   2022.7   （ ISSN:0378-3782 eISSN:1872-6232 ）

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    INTRODUCTION: Infants with congenital diaphragmatic hernia (CDH) are at risk of neurodevelopmental disabilities. This study aimed to investigate the association between lung to thorax transverse area ratio (LTR) and neurodevelopmental outcomes at 3 years of age in fetuses with CDH. METHODS: We performed a retrospective study of infants with prenatally diagnosed isolated left-sided CDH born in Kyushu University Hospital between 2008 and 2016. We examined the association between prenatal ultrasound findings including LTR and development quotient (DQ) at 36 to 42 months of chronological age. RESULTS: We identified 34 live-born fetuses with isolated left-sided CDH, of which 30 survived and four died before discharge. The median LTR in the survivors was higher than in the non-survivors (p < 0.01). Among the survivors, 26 had available data on LTR (median 0.12, range 0.08-0.18) and overall DQ at 3 years of age (93, 61-112). Their median gestational age and birth weight were 37.6 (range 34.4-39.1) weeks and 2716 (2.256-3494) grams, respectively. There was no significant difference in overall DQ scores between the two groups divided according to the median LTR values (p = 0.62). LTR values were not associated with overall DQ scores after adjusting for gestational age (p = 0.39). In addition, no association was observed between LTR values and any subscale DQ scores. CONCLUSION: In fetuses with isolated left-sided CDH, prenatal LTR predicts the mortality but not neurodevelopmental outcomes at 3 years of age.

    DOI： 10.1016/j.earlhumdev.2022.105598

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  • Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study

    Sato, H; Nishikawa, Y; Abe, H; Shiwaku, H; Shiota, J; Sato, C; Sakae, H; Ominami, M; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Terai, S; Inoue, H

    DIGESTIVE ENDOSCOPY   34 ( 5 )   965 - 973   2022.7   （ ISSN:0915-5635 eISSN:1443-1661 ）

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  • Frailty and outcomes in older adults with non-valvular atrial fibrillation from the ANAFIE registry

    Akishita, M; Suzuki, S; Inoue, H; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Morishima, Y; Takita, A; Yamashita, T

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   101   104661   2022.7   （ ISSN:0167-4943 eISSN:1872-6976 ）

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  • 当院NICUで治療を行った未熟児関連消化管機能障害児の中長期的予後に関する検討

    永田 公二, 福田 篤久, 近藤 琢也, 鳥井ヶ原 幸博, 河野 淳, 井上 普介, 落合 正行, 大賀 正一, 田尻 達郎

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   273 - 273   2022.6   （ ISSN:1348-964X eISSN:2435-4996 ）

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  • 大容量情報時代における新生児臨床研究ネットワーク(NRNJ)の役割～さらなる新生児研究の発展を目指して～ NRNJを通じた人材育成

    落合 正行, 井上 普介, 安岡 和昭, 渡部 貴秀, 松下 悠紀, 中嶋 敏紀, 倉田 浩昭

    日本周産期・新生児医学会雑誌   58 ( Suppl.1 )   149 - 149   2022.6   （ ISSN:1348-964X eISSN:2435-4996 ）

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  • Optimal Teicoplanin Dosing Regimen in Neonates and Children Developed by Leveraging Real-World Clinical Information. International journal

    Takaaki Yamada, Chie Emoto, Tsuyoshi Fukuda, Yoshitomo Motomura, Hirosuke Inoue, Shouichi Ohga, Ichiro Ieiri

    Therapeutic drug monitoring   44 ( 3 )   404 - 413   2022.6   （ ISSN:0163-4356 eISSN:1536-3694 ）

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    BACKGROUND: Teicoplanin is a glycopeptide antibiotic used for the treatment of methicillin-resistant Staphylococcus aureus infections. To ensure successful target attainment, therapeutic drug monitoring-informed dosage adjustment is recommended. However, it relies on the experience of the clinician and the frequency of drug measurements. This study aimed to design a new optimal dosing regimen of teicoplanin with a maintenance dosing strategy for neonates and children based on their physiological characteristics. METHODS: Data from teicoplanin-treated patients (n = 214) were collected from electronic medical records. Covariate analyses were performed using population pharmacokinetic (PK) modeling with 399 serum teicoplanin concentrations from 48 neonates and 166 children. Multiple PK simulations were conducted to explore optimal dosing regimens that would allow control of the trough concentration to the target of 15-30 mg/L quicker than the current standard regimen. RESULTS: Allometrically scaled body weight, postmenstrual age (PMA), renal function, and serum albumin were implemented as substantial covariates for teicoplanin clearance in a two-compartment PK model. Covariate analyses and comprehensive simulation assessments recommended the following modifications to the current regimen: 1) decreased dose for premature babies (PMA ≤ 28 weeks), 2) decreased dose for children with renal dysfunction, and 3) increased dose for children (0.5-11 years) with an estimated glomerular filtration rate of ≥90 mL/min/1.73 m2. CONCLUSIONS: This study leverages real-world clinical information and proposes new optimal dosing regimens for teicoplanin in neonates and children through PK modeling and simulation analyses, taking into account the age, including PMA, and renal function of patients.

    DOI： 10.1097/FTD.0000000000000930

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  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 30   2022.5   （ ISSN:0916-8796 ）

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  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 30   2022.5   （ ISSN:0916-8796 ）

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  • 原発性免疫不全症候群に対する臍帯血移植後に脳梗塞を発症し、遺伝性プロテインC欠乏症と診断された乳児例 新生児集中治療における血栓性素因の重要性

    坂口 嘉彬, 園田 素史, 江上 直樹, 井上 普介, 落合 正行, 石村 匡崇, 堀田 多恵子, 内海 健, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 26   2022.5

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  • 原発性免疫不全症候群に対する臍帯血移植後に脳梗塞を発症し、遺伝性プロテインC欠乏症と診断された乳児例 新生児集中治療における血栓性素因の重要性

    坂口 嘉彬, 園田 素史, 江上 直樹, 井上 普介, 落合 正行, 石村 匡崇, 堀田 多恵子, 内海 健, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 26   2022.5

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  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 30   2022.5

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  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 30   2022.5

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  • 原発性免疫不全症候群に対する臍帯血移植後に脳梗塞を発症し、遺伝性プロテインC欠乏症と診断された乳児例 新生児集中治療における血栓性素因の重要性

    坂口 嘉彬, 園田 素史, 江上 直樹, 井上 普介, 落合 正行, 石村 匡崇, 堀田 多恵子, 内海 健, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 26   2022.5   （ ISSN:0916-8796 ）

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  • 原発性免疫不全症候群に対する臍帯血移植後に脳梗塞を発症し、遺伝性プロテインC欠乏症と診断された乳児例 新生児集中治療における血栓性素因の重要性

    坂口 嘉彬, 園田 素史, 江上 直樹, 井上 普介, 落合 正行, 石村 匡崇, 堀田 多恵子, 内海 健, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 1 )   S - 26   2022.5   （ ISSN:0916-8796 ）

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  • Impact of the COVID-19 pandemic on high-resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan

    Ominami, M; Sato, H; Fujiyoshi, Y; Abe, H; Shiwaku, H; Shiota, J; Sato, C; Sakae, H; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Fujiwara, Y; Inoue, H

    DIGESTIVE ENDOSCOPY   34 ( 4 )   769 - 777   2022.5   （ ISSN:0915-5635 eISSN:1443-1661 ）

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  • Pathogenicity of Bordetella bronchiseptica isolated from apparently healthy rabbits in guinea pig, rat, and mouse

    Kameyama, H; Fujimoto, Y; Tomioka, Y; Yamamoto, S; Suyama, H; Inoue, H; Takahashi, E; Ono, E

    JOURNAL OF VETERINARY MEDICAL SCIENCE   84 ( 4 )   574 - 581   2022.4   （ ISSN:0916-7250 eISSN:1347-7439 ）

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  • Factorizing Strings into Repetitions

    Inoue, H; Matsuoka, Y; Nakashima, Y; Inenaga, S; Bannai, H; Takeda, M

    THEORY OF COMPUTING SYSTEMS   66 ( 2 )   484 - 501   2022.4   （ ISSN:1432-4350 eISSN:1433-0490 ）

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  • Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study

    Sato, H; Fujiyoshi, Y; Abe, H; Shiwaku, H; Shiota, J; Sato, C; Sakae, H; Ominami, M; Hata, Y; Fukuda, H; Ogawa, R; Nakamura, J; Tatsuta, T; Ikebuchi, Y; Yokomichi, H; Terai, S; Inoue, H

    JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY   28 ( 2 )   222 - 230   2022.4   （ ISSN:2093-0879 eISSN:2093-0887 ）

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  • Two-year outcomes of more than 30 000 elderly patients with atrial fibrillation: results from the All Nippon AF In the Elderly (ANAFIE) Registry

    Yamashita, T; Suzuki, S; Inoue, H; Akao, M; Atarashi, H; Ikeda, T; Okumura, K; Koretsune, Y; Shimizu, W; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Kaburagi, J; Takita, A

    EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES   8 ( 2 )   202 - 213   2022.3   （ ISSN:2058-5225 eISSN:2058-1742 ）

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  • 新生児単純ヘルペスウイルス感染症の治療指針と課題

    園田 素史, 石村 匡崇, 市山 正子, 藤吉 順子, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   31 ( 2 )   115 - 123   2022.3   （ ISSN:0916-8796 ）

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    新生児単純ヘルペスウイルス(HSV)感染症は、主に垂直感染によって発症する重要な周産期感染症の一つである。臨床病型は表在型(SEM;skin, eye, and mouth)、中枢神経型(CNS;central nervous system)および全身型(Disseminated)の3つに分類され、それぞれ異なる症状と臨床経過を示す。1970年代以降、抗ウイルス薬の登場、またHSV-DNAを検出するPCR法の開発により、早期診断・治療が可能となり飛躍的に治療成績は改善した。しかし新生児医療が高度化した現代においても、全身型の新生児死亡率は29%、中枢神経型は65%以上に神経学的後遺症を残し、依然として予後不良の疾患である。本稿では新生児HSV感染症に対する治療指針と現在の課題について提示する。また新生児ヘルペス脳炎や新生児HSV関連血球貪食性リンパ組織球症といった重症例のリスク因子や治療戦略についても概説する。(著者抄録)

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  • 新生児単純ヘルペスウイルス感染症の治療指針と課題

    園田 素史, 石村 匡崇, 市山 正子, 藤吉 順子, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   31 ( 2 )   115 - 123   2022.3

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    新生児単純ヘルペスウイルス(HSV)感染症は、主に垂直感染によって発症する重要な周産期感染症の一つである。臨床病型は表在型(SEM;skin, eye, and mouth)、中枢神経型(CNS;central nervous system)および全身型(Disseminated)の3つに分類され、それぞれ異なる症状と臨床経過を示す。1970年代以降、抗ウイルス薬の登場、またHSV-DNAを検出するPCR法の開発により、早期診断・治療が可能となり飛躍的に治療成績は改善した。しかし新生児医療が高度化した現代においても、全身型の新生児死亡率は29&#37;、中枢神経型は65&#37;以上に神経学的後遺症を残し、依然として予後不良の疾患である。本稿では新生児HSV感染症に対する治療指針と現在の課題について提示する。また新生児ヘルペス脳炎や新生児HSV関連血球貪食性リンパ組織球症といった重症例のリスク因子や治療戦略についても概説する。(著者抄録)

  • Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans

    Fujita, S; Karasawa, Y; Fujii, M; Hironaka, K; Uda, S; Kubota, H; Inoue, H; Sumitomo, Y; Hirayama, A; Soga, T; Kuroda, S

    NPJ SYSTEMS BIOLOGY AND APPLICATIONS   8 ( 1 )   6   2022.2   （ eISSN:2056-7189 ）

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  • Echocardiographic Structure and Function in Elderly Patients With Atrial Fibrillation in Japan - The ANAFIE Echocardiographic Substudy -

    Hiasa, K; Kaku, H; Kawahara, G; Inoue, H; Yamashita, T; Akao, M; Atarashi, H; Ikeda, T; Koretsune, Y; Okumura, K; Shimizu, W; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Kaburagi, J; Takita, A; Tsutsui, H

    CIRCULATION JOURNAL   86 ( 2 )   222 - +   2022.2   （ ISSN:1346-9843 eISSN:1347-4820 ）

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  • Effect of Cancer on Clinical Outcomes in Elderly Patients With Non-Valvular Atrial Fibrillation-Substudy of the ANAFIE Registry

    Ikeda, T; Yamashita, T; Akao, M; Atarashi, H; Koretsune, Y; Okumura, K; Shimizu, W; Tsutsui, H; Toyoda, K; Hirayama, A; Yasaka, M; Yamaguchi, T; Teramukai, S; Kimura, T; Kaburagi, J; Takita, A; Inoue, H

    CIRCULATION JOURNAL   86 ( 2 )   202 - +   2022.2   （ ISSN:1346-9843 eISSN:1347-4820 ）

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  • Coxsackievirus A11 elicits a potent oncolytic activity in human malignant pleural mesothelioma via ICAM 1 receptor

    Okamura, K; Inoue, H; Ikematsu, Y; Furukawa, R; Tanaka, K; Okamoto, I

    CANCER SCIENCE   113   580 - 580   2022.2   （ ISSN:1347-9032 eISSN:1349-7006 ）

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  • Cytotoxic chemotherapeutic agents and osimertinib induce calreticulin exposure in non-small cell lung cancer

    Furukawa, R; Inoue, H; Ikematsu, Y

    CANCER SCIENCE   113   837 - 837   2022.2   （ ISSN:1347-9032 eISSN:1349-7006 ）

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  • Serum erythroferrone levels during the first month of life in premature infants. International journal

    Nina Lenhartová, Masayuki Ochiai, Toru Sawano, Kazuaki Yasuoka, Junko Fujiyoshi, Hirosuke Inoue, Shouichi Ohga

    Journal of perinatology : official journal of the California Perinatal Association   42 ( 1 )   97 - 102   2022.1   （ ISSN:0743-8346 eISSN:1476-5543 ）

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    OBJECTIVE: To examine erythroferrone (ERFE)-hepcidin iron regulation in premature infants under intensive care at risk of iron metabolic disorders. STUDY DESIGN: A retrospective cohort recruited 31 infants with a birth weight of <1500 g hospitalized in a tertiary center. Their hematological status was measured at birth and 2 and 4 weeks of life. RESULTS: ERFE was positively correlated with the reticulocyte hemoglobin content at 2 (r2 = 0.2374) and 4 weeks (r2 = 0.6005). An assumed negative correlation between ERFE and hepcidin was not determined during the neonatal period. Hepcidin was positively correlated with the leukocyte count (r2 = 0.3089) and ferritin (r2 = 0.7476) at birth and C-reactive protein (r2 = 0.3591) at 2 weeks and negatively correlated with the reticulocyte count (r2 = 0.2887) at 4 weeks. CONCLUSION: The vulnerability of the ERFE-hepcidin pathway within 4 weeks may contribute to iron imbalance in premature infants.

    DOI： 10.1038/s41372-021-01184-6

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  • Clinical Impact of Heritable Thrombophilia on Neonatal-Onset Thromboembolism: A Nationwide Study in Japan. International journal

    Naoki Egami, Masayuki Ochiai, Masako Ichiyama, Hirosuke Inoue, Motoshi Sonoda, Masataka Ishimura, Souichi Suenobu, Toshiya Nishikubo, Akira Ishiguro, Taeko Hotta, Takeshi Uchiumi, Dongchon Kang, Shouichi Ohga

    The Journal of pediatrics   238   259 - 267   2021.11

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    DOI： 10.1016/j.jpeds.2021.07.001

  • Survival outcomes of very low birth weight infants with trisomy 18. International journal

    Hirosuke Inoue, Yuka Matsunaga, Toru Sawano, Junko Fujiyoshi, Tadamune Kinjo, Masayuki Ochiai, Kouji Nagata, Toshiharu Matsuura, Tomoaki Taguchi, Shouichi Ohga

    American journal of medical genetics. Part A   185 ( 11 )   3459 - 3465   2021.11

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    DOI： 10.1002/ajmg.a.62466

  • Neurodevelopmental Outcomes of High-Risk Preterm Infants: A Prospective Study in Japan. International journal

    Michiko Torio, Mariko Iwayama, Toru Sawano, Hirosuke Inoue, Masayuki Ochiai, Ryoji Taira, Kousuke Yonemoto, Yuko Ichimiya, Yuri Sonoda, Momoko Sasazuki, Yoshito Ishizaki, Masafumi Sanefuji, Kenichi Yamane, Hiroshi Yamashita, Hiroyuki Torisu, Ryutaro Kira, Toshiro Hara, Shigenobu Kanba, Yasunari Sakai, Shouichi Ohga

    Neurology. Clinical practice   11 ( 5 )   398 - 405   2021.10

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    DOI： 10.1212/CPJ.0000000000000920

  • Physical growth and neurodevelopment during the first year of life: a cohort study of the Japan Environment and Children's Study. International journal

    Masafumi Sanefuji, Yuri Sonoda, Yoshiya Ito, Masanobu Ogawa, Vlad Tocan, Hirosuke Inoue, Masayuki Ochiai, Masayuki Shimono, Reiko Suga, Ayako Senju, Satoshi Honjo, Koichi Kusuhara, Shouichi Ohga

    BMC pediatrics   21 ( 1 )   360 - 360   2021.8

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    DOI： 10.1186/s12887-021-02815-9

  • Study protocol for a multicentre, open-label, single-arm phase I/II trial to evaluate the safety and efficacy of ripasudil 0.4&#37; eye drops for retinopathy of prematurity. International journal

    Mitsuru Arima, Hirosuke Inoue, Shintaro Nakao, Akiko Misumi, Maya Suzuki, Itsuka Matsushita, Shunsuke Araki, Chiemi Yamashiro, Kazumasa Takahashi, Masayuki Ochiai, Noriko Yoshida, Masayuki Hirose, Junji Kishimoto, Koji Todaka, Shunji Hasegawa, Kazuhiro Kimura, Koichi Kusuhara, Hiroyuki Kondo, Shouichi Ohga, Koh-Hei Sonoda

    BMJ open   11 ( 7 )   e047003   2021.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1136/bmjopen-2020-047003

  • Trends in Bronchopulmonary Dysplasia Among Extremely Preterm Infants in Japan, 2003-2016. International journal

    Toshinori Nakashima, Hirosuke Inoue, Yoshihiro Sakemi, Masayuki Ochiai, Hironori Yamashita, Shouichi Ohga

    The Journal of pediatrics   230   119 - 125   2021.3

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    DOI： 10.1016/j.jpeds.2020.11.041

  • 胎児・新生児期における原発性免疫不全症の早期診断の意義

    江口 克秀, 石村 匡崇, 坂井 淳彦, 是松 辰哉, 矢田 裕太郎, 園田 素史, 白石 暁, 城戸 咲, 井上 普介, 落合 正行, 加藤 聖子, 大賀 正一

    日本産婦人科・新生児血液学会誌   30 ( 1 )   S - 58   2020.12

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  • 本邦における新生児単純ヘルペス感染症の全国疫学調査

    園田 素史, 石村 匡崇, 市山 正子, 藤吉 順子, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   30 ( 1 )   S - 44   2020.12

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  • 新生児期に診断された重症血友病Aに対するインヒビター発生抑制のための治療選択

    江口 克秀, 石村 匡崇, 江口 祥美, 木下 恵志郎, 矢田 裕太郎, 園田 素史, 白石 暁, 井上 普介, 落合 正行, 大賀 正一

    日本小児血液・がん学会雑誌   57 ( 4 )   304 - 304   2020.10

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  • Management of apnea in infants with trisomy 18. Reviewed International journal

    Ryoji Taira, Hirosuke Inoue, Toru Sawano, Junko Fujiyoshi, Yuko Ichimiya, Michiko Torio, Masafumi Sanefuji, Masayuki Ochiai, Yasunari Sakai, Shouichi Ohga

    Developmental medicine and child neurology   62 ( 7 )   874 - 878   2020.7

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    DOI： 10.1111/dmcn.14403

  • 胎児エコーと特徴的な腎外症状から早期に診断し得たPierson症候群の1例

    山本 俊亮, 西山 慶, 是松 辰哉, 黒川 麻里, 今井 崇史, 井上 普介, 落合 正行, 城戸 咲, 加藤 聖子, 大賀 正一

    日本小児腎不全学会雑誌   40   173 - 175   2020.7

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    母体は28歳の経産婦であった。在胎29週5日に胎児エコーで異常を指摘された。両腎は腫大のない高輝度エコーを呈し、羊水過少および肺低形成を認め、特徴的なエコー所見から先天性ネフローゼ症候群を疑った。出生時、両側瞳孔はピンホール状であり、胎児腎エコー所見と併せてPierson症候群を疑った。無尿が持続し、日齢9に腹膜透析(PD)カテーテルを留置し、日齢11にPDによる維持透析を開始した。遺伝子パネル解析でLAMB2のヘテロ接合体遺伝子変異を検出し、父母由来のアレル上に同様の変異を認め、Pierson症候群と確定診断した。両腎の正常～軽度腫大を呈する高輝度エコー像を示す疾患は、早期治療介入が必要な疾患が多く、重要な所見である。特徴的な腎外症状と組み合わせることにより、早期の診断・治療介入が可能になると考えられた。(著者抄録)

  • Transcutaneous blood gas monitoring among neonatal intensive care units in Japan. Reviewed International journal

    Masayuki Ochiai, Hiroaki Kurata, Hirosuke Inoue, Masako Ichiyama, Junko Fujiyoshi, Shinichi Watabe, Takehiko Hiroma, Tomohiko Nakamura, Shouichi Ohga

    Pediatrics international : official journal of the Japan Pediatric Society   62 ( 2 )   169 - 174   2020.2

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    DOI： 10.1111/ped.14107

  • Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis Reviewed

    Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Akira Shiraishi, Shunsuke Kanno, Noriyuki Kaku, Hirosuke Inoue, Yoshitomo Motomura, Masayuki Ochiai, Yasunari Sakai, Manabu Nakayama, Osamu Ohara, Shouichi Ohga

    International journal of hematology   111 ( 1 )   131 - 136   2020.1

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    DOI： 10.1007/s12185-019-02738-3

  • Neurodevelopmental outcomes following intravitreal bevacizumab injection in Japanese preterm infants with type 1 retinopathy of prematurity. Reviewed International journal

    Mitsuru Arima, Masato Akiyama, Kohta Fujiwara, Yujiro Mori, Hirosuke Inoue, Eiko Seki, Takahito Nakama, Shoko Tsukamoto, Masayuki Ochiai, Shouichi Ohga, Koh-Hei Sonoda

    PloS one   15 ( 3 )   e0230678   2020.1

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    DOI： 10.1371/journal.pone.0230678

  • Association of perinatal factors of epilepsy in very low birth weight infants, using a nationwide database in Japan Reviewed International journal

    Yuki Matsushita, Yasunari Sakai, Michiko Torio, Hirosuke Inoue, Masayuki Ochiai, Kazuaki Yasuoka, Hiroaki Kurata, Junko Fujiyoshi, Masako Ichiyama, Tomoaki Taguchi, Kiyoko Kato, Shouichi Ohga

    Journal of Perinatology   39 ( 11 )   1472 - 1479   2019.11

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    DOI： 10.1038/s41372-019-0494-7

  • Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia Reviewed

    Hiroaki Kurata, Masayuki Ochiai, Hirosuke Inoue, Takeshi Kusuda, Junko Fujiyoshi, Masako Ichiyama, Yoshifumi Wakata, Hidetoshi Takada

    Pediatrics and Neonatology   60 ( 5 )   496 - 503   2019.10

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    DOI： 10.1016/j.pedneo.2018.11.007

  • 低出生体重児における修正6歳時の発達状況に関連する評価の検討 Dubowitz神経学的評価に着目して

    落石 慶衣, 草葉 隆一, 上島 隆秀, 藤田 曜生, 樋口 妙, 宮里 幸, 海山 京子, 最所 雅, 北里 直子, 井上 普介, 落合 正行, 川口 謙一, 中島 康晴

    56 ( 秋季特別号 )   S394 - S394   2019.10

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  • Late-Onset Circulatory Collapse and Risk of Cerebral Palsy in Extremely Preterm Infants Reviewed

    Kazuaki Yasuoka, Hirosuke Inoue, N. Egami, Masayuki Ochiai, Koichi Tanaka, Toru Sawano, Hiroaki Kurata, Masako Ichiyama, J. Fujiyoshi, Yuki Matsushita, Yasunari Sakai, Shouichi Ohga

    Journal of Pediatrics   212   117 - 123.e4   2019.9

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    DOI： 10.1016/j.jpeds.2019.05.033

  • 母体のアンギオテンシン受容体拮抗薬(ARB)中止後に右心不全による胎児水腫をきたした1例 Reviewed

    黒川 麻里, 西山 慶, 永田 弾, 井上 普介, 落合 正行, 城戸 咲, 加藤 聖子, 大賀 正一

    日本小児腎不全学会雑誌   39   138 - 141   2019.7

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    非免疫性胎児水腫の原因は多岐に渡るが、その成因が不明なものも2割程度存在する。母体のアンギオテンシン受容体拮抗薬(angiotensin II receptor blocker:ARB)内服による尿細管形成不全をきたした児(ARB fetopathy)が、妊娠後期にARBを中止後に胎児水腫を発症した。胎児心エコーでは右心不全の所見を認めた。出生後、浮腫が速やかに消失し、胎児水腫は母体要因である可能性が考えられた。母体および胎盤由来のレニン・アルドステロンが直接胎児に影響した可能性を疑ったが、出生後のレニン・アルドステロン値の推移からは否定的であった。元来妊娠中でレニン・アンギオテンシン・アルドステロン系(Renin-Angiotensin-Aldosterone System:RAAS)が亢進しており、ARBの中止という特異的な状況が加わり、母体でのNa、水再吸収が増加、母体・胎盤の浮腫から胎児の前負荷の増加につながり、右心不全、胎児水腫をきたしたのではないかと推測した。(著者抄録)

  • 母児間輸血症候群を合併した先天性完全房室ブロックの極低出生体重児

    福岡 将治, 長友 雄作, 江口 祥美, 村岡 衛, 江上 直樹, 澤野 徹, 市山 正子, 井上 普介, 平田 悠一郎, 永田 弾, 落合 正行, 大賀 正一

    日本小児科学会雑誌   123 ( 6 )   1081 - 1081   2019.6

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  • 超早産児の晩期循環不全は脳性麻痺の危険因子である「周産期母子医療センターネットワーク10年まとめ事業」

    井上 普介, 松下 悠紀, 落合 正行, 石崎 義人, 實藤 雅文, 酒井 康成, 大賀 正一

    脳と発達   51 ( Suppl. )   S275 - S275   2019.5

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  • 新生児期の集学的治療によって救命し得た最重症型α0-サラセミア症例に対する造血細胞移植

    園田 素史, 石村 匡崇, 江口 克秀, 市山 正子, 藤吉 順子, 井上 普介, 落合 正行, 金城 唯宗, 高畑 靖, 大賀 正一

    日本産婦人科・新生児血液学会誌   29 ( 1 )   S - 68   2019.5

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  • 極低出生体重児の9歳時の神経学的予後 単施設の報告

    鳥尾 倫子, 岩山 真理子, 井上 普介, 落合 正行, 園田 有里, 石崎 義人, 實藤 雅文, 酒井 康成, 大賀 正一

    脳と発達   51 ( Suppl. )   S349 - S349   2019.5

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  • 新生児単純ヘルペスウイルス関連血球貪食性リンパ組織球症(HSV-HLH)

    園田 素史, 石村 匡崇, 市山 正子, 藤吉 順子, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   28 ( 2 )   63 - 70   2019.3

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    新生児単純ヘルペスウィルス(HSV)感染症は主に産道感染によって新生児に発症する周産期感染症の重要な疾患の一つである。全身型、中枢神経型、表在型の3つの病型に分けられるが、特に全身型は新生児早期に発症し、一部ではHSV関連血球貪食性リンパ組織球症(HSV-HLH)に進展して、急激に致死的な経過をたどる予後不良な疾患である。救命のためには新生児HSV感染症を疑った時点で抗ウイルス薬の投与を開始することが、重症化の予防および生命予後の改善のために重要である。また新生児HSV-HLHに関しては高サイトカイン血症に基づいた重篤なDICの病態を合併していることから、適切な抗サイトカイン治療の選択も重要であると考えられる。しかしながら未だ新生児HSV-HLHの病態や治療に関する情報は乏しく、より良い診療のためには早期診断・治療の指針の確立が急務と考えられる。(著者抄録)

  • Diagnostic challenge of the newborn patients with heritable protein C deficiency Reviewed International journal

    Masako Ichiyama, Hirosuke Inoue, Masayuki Ochiai, masataka ishimura, Akira Shiraishi, Junko Fujiyoshi, Hironori Yamashita, Kazuo Sato, Shinya Matsumoto, Taeko Hotta, Takeshi Uchiumi, Dongchon Kang, Shoichi Ohga

    Journal of Perinatology   39 ( 2 )   212 - 219   2019.2

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    DOI： 10.1038/s41372-018-0262-0

  • 出生体重500g以下児の3歳時神経学的予後「NRN10年まとめ事業」

    井上 普介, 酒井 康成, 安岡 和昭, 田中 幸一, 市山 正子, 倉田 浩昭, 藤吉 順子, 松下 悠紀, 本荘 哲, 落合 正行, 大賀 正一

    日本小児科学会雑誌   123 ( 2 )   304 - 304   2019.2

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  • A nationwide survey on tracheostomy for very-low-birth-weight infants in Japan Reviewed International journal

    Hiroaki Kurata, Masayuki Ochiai, Hirosuke Inoue, Masako Ichiyama, Kazuaki Yasuoka, Junko Fujiyoshi, Yuki Matsushita, Satoshi Honjo, Yasunari Sakai, Shoichi Ohga

    Pediatric Pulmonology   54 ( 1 )   53 - 60   2019.1

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    DOI： 10.1002/ppul.24200

  • Neurodevelopmental outcomes in infants with birth weight ≤500 g at 3 years of age Reviewed International journal

    142 ( 6 )   2018.12

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    OBJECTIVES: To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS: Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study population consisted of 460 children (56.7&#37; of 811 surviving infants) who were evaluated at 36 to 42 months of age. Neurodevelopmental impairment (NDI) was defined as having cerebral palsy, visual impairment, hearing impairment, or a developmental quotient score of <70. RESULTS: The overall proportion of NDI was 59.1&#37; (95&#37; confidence interval [CI]: 54.6&#37;-63.5&#37;). The trend revealed no significant change during the study period. In a multivariate modified Poisson regression analysis, NDI was associated with severe intraventricular hemorrhage (adjusted risk ratio [RR]: 1.42; 95&#37; CI: 1.19-1.68; P <.01), cystic periventricular leukomalacia (adjusted RR: 1.40; 95&#37; CI: 1.13-1.73; P <.01), severe necrotizing enterocolitis (adjusted RR: 1.31; 95&#37; CI: 1.07-1.60; P <.01), surgical ligation for patent ductus arteriosus (adjusted RR: 1.29; 95&#37; CI: 1.09-1.54; P <.01), and male sex (adjusted RR: 1.19; 95&#37; CI: 1.01-2.40; P =.04). CONCLUSIONS: This cohort showed that neurodevelopmental outcomes of infants with a BW of ≤500 g have not improved from 2003 to 2012. Multivariate analysis revealed that severe intracranial hemorrhage and cystic periventricular leukomalacia were the strongest risk factors for NDIs. Our data suggested that measures aimed at reducing neurologic morbidities will be important for improving outcomes of infants with a BW of ≤500 g.

    DOI： 10.1542/peds.2017-4286

  • 壊死性腸炎を発症した双胎間貧血多血Sequenceの供血児例 Reviewed

    江上 直樹, 井上 普介, 大山 紀子, 澤野 徹, 市山 正子, 藤吉 順子, 落合 正行, 柳 佑典, 伊崎 智子, 蜂須賀 正紘, 日高 庸博, 加藤 聖子, 田口 智章, 大賀 正一

    福岡医学雑誌   109 ( 4 )   96 - 100   2018.12

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    母体は33歳で、妊娠6週時に一絨毛膜性二羊膜双胎妊娠と診断され、両児の体重、羊水量、中大脳動脈最高血流速度は正常範囲内であった。妊娠29週1日に分娩が進行して緊急帝王切開分娩となり、第1児は出生体重1234g、第2児は1002g、ヘモグロビン値は第1児が18.4g/dL、第2児が6.0g/dLであり、第1児が双胎間貧血多血Sequence受血児、第2児を供血児と診断した。第1児は部分交換輸血により合併症なく日齢58に退院した。第2児は出生後に濃厚赤血球輸血、非侵襲的陽圧換気を行い、日齢2より人工乳にて経腸栄養を開始したが、日齢10に新生児壊死性腸炎を発症した。緊急開腹手術にて壊死した小腸を45cm切除し人工肛門を造設した。術後7日より経腸栄養を再開し、116日後に人工肛門閉鎖術を実施した。閉鎖術後94日の消化管造影で短腸症候群と診断し、中心静脈栄養と低出生体重児用ミルクを用いた頻回授乳を併用し、日齢232に体重3324gで退院した。

  • 【How to Follow-up Q&A-2018アップデート】予後 超低出生体重児 出生体重500g以下児の救命率、合併症と予後

    落合 正行, 井上 普介

    周産期医学   48 ( 9 )   1115 - 1117   2018.9

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  • 新生児臨床研究ネットワークデータベースに基づいた出生体重500g以下児の3歳時神経学的予後の調査

    井上 普介, 松下 悠紀, 落合 正行, 石崎 義人, 實藤 雅文, 酒井 康成, 大賀 正一

    脳と発達   50 ( Suppl. )   S345 - S345   2018.5

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  • 新生児とDIC 新生児HSV関連血球貪食性リンパ組織球症(HSV-HLH) 病態と予後因子の検討

    園田 素史, 石村 匡崇, 市山 正子, 藤吉 順子, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   28 ( 1 )   S - 24   2018.5

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  • Dubowitz神経学的評価を実施した低出生体重児のフォローアップ経過 Reviewed

    最所 雅, 草葉 隆一, 落石 慶衣, 海山 京子, 上島 隆秀, 藤田 曜生, 樋口 妙, 北里 直子, 宮里 幸, 上野 ふじ美, 井上 普介, 落合 正行, 川口 謙一, 中島 康晴

    国立大学リハビリテーション療法士学術大会誌   39回   15 - 18   2018.3

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    2009年～2010年にNICUに入院しDubowitz神経学的評価を実施した低出生体重児42名(男24名、女18名)を、出生体重1500g未満(ハイリスク群)21名と出生体重1500g以上2500g未満(通常群)21名に分け、7～8年間の長期的な発達の経過を比較調査した。就学前6歳時点でフォロー継続できているのはハイリスク群19名、通常群7名であり、療育介入はハイリスク群10名、通常群3名であった。Dubowitz神経学的評価にてtotal scoreの平均値はハイリスク群・通常群ともに23.3点であり、27点未満はハイリスク群17名、通常群16名であった。そのうち運動発達障害を有するのはハイリスク群・通常群とも3例ずつであり、total scoreが27点以上で運動発達障害を有する者はいなかった。精神発達遅滞、発達障害を有する者はtotal scoreが27点未満・27点以上の両方に存在し、かつハイリスク群・通常群の両群に存在した。

  • 低出生体重児の就学先からみた新生児神経学的評価と発達検査について Reviewed

    海山 京子, 草葉 隆一, 落石 慶衣, 最所 雅, 上島 隆秀, 藤田 曜生, 樋口 妙, 北里 直子, 宮里 幸, 井上 普介, 落合 正行, 川口 謙一, 中島 康晴

    国立大学リハビリテーション療法士学術大会誌   39回   19 - 21   2018.3

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    2009年～2010年に出生した低出生体重児42例のうち、就学先を把握できた24例を対象として、6歳時のWechsler Intelligence Scale of Children-IV(WISC-IV)、3歳時および1.5歳時の新版K式検査による発達検査と、新生児期のDubowitz神経学的評価を用いて、就学先による差違を後方視的に検討した。就学先は、通常学級14例(男児12例、女児2例)、支援学級・支援学校10例(男児3例、女児7例)であった。WISC-IVにおいて言語理解、知覚推理、ワーキングメモリー、処理速度、全検査の各項目において2群間で有意差を認めた。3歳時K式検査では姿勢-運動、認知-適応、言語-社会、全領域において、1.5歳時K式検査では認知-適応、言語-社会、全領域において2群間で有意差を認めた。Dubowitz評価ではtotalスコア・各スコアともに2群間で有意差は認めなかった。

  • Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis Reviewed

    Tadamune Kinjo, Hirosuke Inoue, Takeshi Kusuda, Junko Fujiyoshi, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Yuhki Koga, Toshiro Hara, Shoichi Ohga

    Pediatrics and Neonatology   2018.1

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    DOI： 10.1016/j.pedneo.2018.09.005

  • TAM関連性肝硬変に対し生体肝移植を施行したDown症児の1例

    松浦 俊治, 高橋 良彰, 吉丸 耕一朗, 井上 普介, 落合 正行, 大賀 正一, 田口 智章

    日本小児栄養消化器肝臓学会雑誌   31 ( 2 )   103 - 103   2017.12

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  • Early Mortality and Morbidity in Infants with Birth Weight of 500 Grams or Less in Japan Reviewed

    190   112 - 117.e3   2017.11

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    Objective To assess the short-term prognosis of Japanese infants with a birth weight (BW) of ≤500 g. Study design Demographic and clinical data were reviewed for 1473 live born infants with a BW ≤500 g at gestational age ≥22 weeks who were treated in the 204 affiliated hospitals of the Neonatal Research Network of Japan between 2003 and 2012. Results Survival to hospital discharge occurred in 811 of 1473 infants (55&#37;; 95&#37; CI 53&#37;-58&#37;). The survival rates of BW ≤300 g, 301-400 g, and 401-500 g were 18&#37; (95&#37; CI 10&#37;-31&#37;), 41&#37; (95&#37; CI 36&#37;-47&#37;), and 60&#37; (95&#37; CI 57&#37;-63&#37;), respectively. In a multivariable Cox proportional hazards analysis, antenatal corticosteroid use (adjusted hazard ratio: 0.68; 95&#37; CI 0.58-0.81; P <.01), cesarean delivery (0.69; 95&#37; CI 0.56-0.85; P <.01), advanced gestational age per week (0.94; 95&#37; CI 0.89-0.99; P =.02), BW per 100-g increase (0.55; 95&#37; CI 0.49-0.64; P <.01), Apgar score ≥4 at 5 minutes (0.51; 95&#37; CI 0.43-0.61; P <.01), and no major congenital abnormalities (0.38; 95&#37; CI 0.29-0.51; P <.01) were associated with survival to discharge. Despite the improved survival rate over the 10-year study period (from 40&#37; in 2003 [95&#37; CI 30&#37;-51&#37;] to 68&#37; in 2012 [95&#37; CI 61&#37;-75&#37;]), at least 1 severe morbidity was present in 81&#37;-89&#37; of the survivors. Conclusions Improvements in perinatal-neonatal medicine have improved the survival, but not the rate of major morbidities, of infants with a BW ≤500 g in Japan.

    DOI： 10.1016/j.jpeds.2017.05.017

  • 新生児単純ヘルペスウイルス関連血球貪食性リンパ組織球症(HSV-HLH)の診療方針の確立を目指して 新生児HSV-HLH 2例を基に考察

    園田 素史, 井上 普介, 市山 正子, 藤吉 順子, 落合 正行, 江口 克秀, 白石 暁, 石村 匡崇, 神野 俊介, 賀耒 典之, 高田 英俊, 大賀 正一

    日本新生児成育医学会雑誌   29 ( 3 )   587 - 587   2017.10

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  • Successful liver transplantation for transient abnormal myelopoiesis-associated liver failure Reviewed

    Kazuaki Yasuoka, Hirosuke Inoue, Koichi Tanaka, Junko Fujiyoshi, Yuki Matsushita, Masayuki Ochiai, Yuhki Koga, Toshiharu Matsuura, Tomoaki Taguchi, Shoichi Ohga

    Neonatology   112 ( 2 )   159 - 162   2017.8

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    DOI： 10.1159/000474930

  • 新生児臨床研究ネットワークデータベースに基づいた極低出生体重児の神経学的後遺症に関わる予後因子の解析

    松下 悠紀, 落合 正行, 井上 普介, 米元 耕輔, 赤峰 哲, 石崎 義人, 實藤 雅文, 酒井 康成, 高田 英俊, 大賀 正一

    脳と発達   49 ( Suppl. )   S330 - S330   2017.5

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  • Transient Hemi-Lower Limb Ischemia in the Newborn: Arterial Thrombosis or Persistent Sciatic Artery? Reviewed International journal

    Makiko Kirino, Masayuki Ochiai, Masako Ichiyama, Hirosuke Inoue, Takeshi Kusuda, Tadamune Kinjo, Masataka Ishimura, Shouichi Ohga

    AJP Rep   7 ( 1 )   e13 - e16   2017.1

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    Transient Hemi-Lower Limb Ischemia in the Newborn: Arterial Thrombosis or Persistent Sciatic Artery?
    Neonatal thromboembolism occurs with various predispositions and triggers. Early diagnosis of the thrombosis is challenging and essential for the therapeutic interventions. We herein report two newborns who presented with transient hemi-lower limb ischemia due to (1) arterial thrombosis or (2) a persistent sciatic artery (PSA). The patient with arterial thrombosis showed elevations of fibrin degradation product and D-dimer and received antithrombin and heparin intravenously. The patient with PSA was immediately assessed by a contrast-enhanced computed tomography because of a transient ischemic episode with no evidence of hypercoagulability. Newborns suspected of having arterial thrombosis may need urgent surgical intervention along with thrombolytic and anticoagulant therapy to prevent organ ischemia and amputation of extremities. Conversely, some PSA cases have reportedly been treated conservatively. This vascular anomaly was previously reported as a cause of lower limb ischemia only in a newborn. PSA is a critical differential diagnosis of neonatal arterial thrombosis that needs urgent therapeutic intervention.

    DOI： 10.1055/s-0037-1598044

  • An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very-Low-Birth-Weight Infants. Reviewed International journal

    Masayuki Ochiai, Hirosuke Inoue

    2017.1

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  • An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very-Low-Birth-Weight Infants Reviewed

    Masayuki Ochiai, Hiroaki Kurata, Hirosuke Inoue, Koichi Tanaka, Yuki Matsushita, Junko Fujiyoshi, Yoshifumi Wakata, Kiyoko Kato, Tomoaki Taguchi, Hidetoshi Takada

    Neonatology   111 ( 1 )   68 - 75   2016.12

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    DOI： 10.1159/000447991

  • Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan. Reviewed International journal

    Masayuki Ochiai, Hirosuke Inoue

    PloS one   11 ( 8 )   e0161439   2016.8

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    DOI： 10.1371/journal.pone.0161439

  • Blood reference intervals for preterm low-birth-weight infants A multicenter cohort study in Japan Reviewed International journal

    Masayuki Ochiai, Yuki Matsushita, Hirosuke Inoue, Takeshi Kusuda, Dongchon Kang, Kiyoshi Ichihara, Naoki Nakashima, Kenji Ihara, Shoichi Ohga, Toshiro Hara

    PLoS One   11 ( 8 )   e0161439   2016.8

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    DOI： 10.1371/journal.pone.0161439

  • SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7 Reviewed International journal

    Satoshi Narumi, Naoko Amano, Tomohiro Ishii, Noriyuki Katsumata, Koji Muroya, Masanori Adachi, Katsuaki Toyoshima, Yukichi Tanaka, Ryuji Fukuzawa, Kenichi Miyako, Saori Kinjo, Shoichi Ohga, Kenji Ihara, Hirosuke Inoue, Tadamune Kinjo, Toshiro Hara, Miyuki Kohno, Shiro Yamada, Hironaka Urano, Yosuke Kitagawa, Koji Tsugawa, Asumi Higa, Masakazu Miyawaki, Takahiro Okutani, Zenro Kizaki, Hiroyuki Hamada, Minako Kihara, Kentaro Shiga, Tetsuya Yamaguchi, Manabu Kenmochi, Hiroyuki Kitajima, Maki Fukami, Atsushi Shimizu, Jun Kudoh, Shinsuke Shibata, Hideyuki Okano, Noriko Miyake, Naomichi Matsumoto, Tomonobu Hasegawa

    Nature Genetics   48 ( 7 )   792 - 797   2016.7

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    DOI： 10.1038/ng.3569

  • SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7. Reviewed International journal

    Narumi S, Hirosuke Inoue

    Nature genetics   48 ( 7 )   792 - 7   2016.7

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    DOI： 10.1038/ng.3569.

  • Longitudinal analysis of serum cystatin C for estimating the glomerular filtration rate in preterm infants. Reviewed International journal

    Nakashima T, Hirosuke Inoue

    2016.6

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    DOI： 10.1007/s00467-015-3309-x.

  • Activation of Nod1 Signaling Induces Fetal Growth Restriction and Death through Fetal and Maternal Vasculopathy. Reviewed International journal

    Hirosuke Inoue

    2016.5

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    DOI： 10.4049/jimmunol.1500295.

  • 低出生体重児の発達予後を予測する評価の検討 Dubowitz神経学的評価の有用性 Reviewed

    落石 慶衣, 草葉 隆一, 上島 隆秀, 藤田 曜生, 樋口 妙, 宮里 幸, 海山 京子, 北里 直子, 井上 普介, 落合 正行

    国立大学リハビリテーション療法士学術大会誌   37回   66 - 70   2016.3

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    NICUに入院した神経学的評価が可能な低出生体重児42名(男児24名、女児18名、在胎週数中央値32週6日、出生体重中央値1564g)を対象に、1歳半時、3歳時の発達状況を調査した。新版K式発達検査(K式)で3歳まで追跡できたのは18名であった。K式全領域の発達指数(DQ)と有意な相関関係を認めたのは、1歳半時ではDubowitz神経学的評価法のToneとTotalであり、3歳児では同評価のToneとApgar score(5分)であった。特にToneは全領域DQや姿勢-運動DQだけでなく、1歳半時で認知-適応DQ、3歳時で言語-社会DQとも有意な相関関係を認めた。3歳時の全領域DQが70未満の7名ではToneのcolumn 2が多く、70以上の11名ではcolumn 4が多い傾向であった。NICU退院時のMRIで2名がPVLと診断され、Dubowitz Totalは14.5点と17点で42名中の最低点と次点であり、14.5点の児は1歳半時、3歳時ともK式で低値を示し、後に脳性麻痺と診断されていた。

  • Activation of Nod1 signaling induces fetal growth restriction and death through fetal and maternal vasculopathy Reviewed

    Hirosuke Inoue, Hisanori Nishio, Hidetoshi Takada, Yasunari Sakai, Etsuro Nanishi, Masayuki Ochiai, Mitsuho Onimaru, Si Jing Chen, Toshiro Matsui, Toshiro Hara

    Journal of Immunology   196 ( 6 )   2779 - 2787   2016.3

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    DOI： 10.4049/jimmunol.1500295

  • Longitudinal analysis of serum cystatin C for estimating the glomerular filtration rate in preterm infants Reviewed

    Toshinori Nakashima, Hirosuke Inoue, Junko Fujiyoshi, Naoko Matsumoto

    Pediatric Nephrology   31 ( 6 )   983 - 989   2016.1

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    DOI： 10.1007/s00467-015-3309-x

  • Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism. Reviewed International journal

    Ichiyama Masako, Hirosuke Inoue

    Pediatric research   79 ( 1-1 )   81 - 6   2016.1

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    DOI： 10.1038/pr.2015.180.

  • Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism Reviewed International journal

    Masako Ichiyama, Shoichi Ohga, Masayuki Ochiai, Koichi Tanaka, Yuka Matsunaga, Takeshi Kusuda, Hirosuke Inoue, masataka ishimura, Tomohito Takimoto, Yui Koga, Taeko Hotta, Dongchon Kang, Toshiro Hara

    Pediatric Research   79 ( 1 )   81 - 86   2016.1

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    DOI： 10.1038/pr.2015.180

  • Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells Reviewed International journal

    Kazuhiro Okubo, Yasunari Sakai, Hirosuke Inoue, Satoshi Akamine, Yoshito Ishizaki, Yuki Matsushita, Masafumi Sanefuji, Hiroyuki Torisu, Kenji Ihara, Marco Sardiello, Toshiro Hara

    Scientific Reports   5   13191 - 13191   2015.8

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    DOI： 10.1038/srep13191

  • Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells. Reviewed International journal

    Scientific reports   5   13191 - 13191   2015.8

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    DOI： 10.1038/srep13191.

  • 自然免疫受容体Nod1のリガンドは母仔の血管病変を介してIUGRおよびIUFDをおこす

    井上 普介, 西尾 寿乗, 高田 英俊, 酒井 康成, 名西 悦郎, 落合 正行, 原 寿郎

    日本産婦人科・新生児血液学会誌   25 ( 1 )   S - 92   2015.5

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  • Perinatal management of preterm premature ruptured membranes affects neonatal prognosis. Reviewed International journal

    Arisa Fujiwara, Hirosuke Inoue

    2014.7

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    DOI： 10.1515/jpm-2013-0192.

  • Perinatal management of preterm premature ruptured membranes affects neonatal prognosis Reviewed

    Arisa Fujiwara, Kotaro Fukushima, Hirosuke Inoue, Takeshi Takashima, Hiromasa Nakahara, Shoji Satoh, Masayuki Ochiai, Toshiro Hara, Mototsugu Shimokawa, Kiyoko Kato

    Journal of Perinatal Medicine   42 ( 4 )   499 - 505   2014.1

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    DOI： 10.1515/jpm-2013-0192

  • Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants Reviewed

    Hirosuke Inoue, Shoichi Ohga, Takeshi Kusuda, Junko Kitajima, Tadamune Kinjo, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Toshiro Hara

    Early Human Development   89 ( 6 )   425 - 429   2013.6

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    DOI： 10.1016/j.earlhumdev.2012.12.011

  • Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. Reviewed International journal

    Hirosuke Inoue

    2013.6

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    DOI： 10.1016/j.earlhumdev.2012.12.011.

  • Successful treatment of a patient with tumor necrosis factor receptor-associated periodic syndrome using a half-dose of etanercept Reviewed International journal

    Koichi Kusuhara, Takayuki Hoshina, Mitsumasa Saito, masataka ishimura, Hirosuke Inoue, Takahiko Horiuchi, Tetsuji Sato, Toshiro Hara

    Pediatrics International   54 ( 4 )   552 - 555   2012.8

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    DOI： 10.1111/j.1442-200X.2011.03525.x

  • Differential transmission and postnatal outcomes in triplets with intrauterine cytomegalovirus infection Reviewed

    Junko Kitajima, Hirosuke Inoue, Shoichi Ohga, Tadamune Kinjo, Masayuki Ochiai, Takahisa Yoshida, Koichi Kusuhara, Toshiro Hara

    Pediatric and Developmental Pathology   15 ( 2 )   151 - 155   2012.7

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    DOI： 10.2350/11-05-1034-CR.1

  • Tracheal aspirate gene expression in preterm newborns and development of bronchopulmonary dysplasia Reviewed

    Shunji Hikino, Shoichi Ohga, Tadamune Kinjo, Takeshi Kusuda, Masayuki Ochiai, Hirosuke Inoue, Satoshi Honjo, Kenji Ihara, Koichi Ohshima, Toshiro Hara

    Pediatrics International   54 ( 2 )   208 - 214   2012.4

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    DOI： 10.1111/j.1442-200X.2011.03510.x

  • 新生児における鉄恒常性とヘプシジン Reviewed

    北島 順子, 金城 唯宗, 大賀 正一, 落合 正行, 井上 普介, 楠田 剛, 井原 健二, 原 寿郎

    日本産婦人科・新生児血液学会誌   20 ( 2 )   103 - 111   2011.3

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    鉄は、酸素を運搬するヘモグロビンの構成原子であるが、エネルギー産生、核酸合成などに必須の微量元素である。一方、この重金属は毒性のある活性酸素種の産生源でもあるため生体は厳密な制御機構を有している。鉄の恒常性を司るいくつかの因子は感染や炎症にも関わる分子であり、細胞内外における鉄代謝の仕組みが解明されつつある。新生児とくに低出生体重児は、鉄代謝機構が未熟なため、鉄欠乏と過剰に陥りやすく、神経障害、慢性肺疾患、および未熟児網膜症への影響が懸念されている。しかし、周産期における胎児・新生児の鉄代謝は未開拓の分野であり、輸血や鉄剤投与の方法に関して多くの議論がある。ここでは肝から産生される鉄代謝ホルモン、hepcidinを中心に新生児における鉄の恒常性維持機構について概説する。(著者抄録)

  • Congenital multiple pituitary hormone deficiency associated with hyperammonemia A case report with a short review of the literature Reviewed

    Hirosuke Inoue, K. Ihara, Masayuki Ochiai, Y. Takahata, H. Kohno, T. Hara

    Journal of Perinatology   31 ( 2 )   146 - 148   2011.2

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    DOI： 10.1038/jp.2010.143

  • A novel SCN5A mutation associated with the linker between III and IV domains of Na_v 1.5 in a neonate with fatal long QT syndrome Reviewed

    Yamamura Kenichiro, Muneuchi Jun, Uike Kiyoshi, Ikeda Kazuyuki, Inoue Hirosuke, Takahata Yasushi, Shiokawa Yuichi, Yoshikane Yukako, Makiyama Takeru, Horie Minoru, Hara Toshiro

    International Journal of Cardiology   145 ( 1 )   61 - 64   2010.11

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    A novel SCN5A mutation associated with the linker between III and IV domains of Na v 1.5 in a neonate with fatal long QT syndrome

    DOI： 10.1016/j.ijcard.2009.04.023

  • Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism Reviewed

    Hirosuke Inoue, Hidetoshi Takada, Takeshi Kusuda, Takako Goto, Masayuki Ochiai, Tadamune Kinjo, Jun Muneuchi, Yasushi Takahata, Naomi Takahashi, Tomohiro Morio, Kenjiro Kosaki, Toshiro Hara

    European Journal of Pediatrics   169 ( 7 )   839 - 844   2010.7

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    DOI： 10.1007/s00431-009-1126-6

  • Toxic shock syndrome-like exanthematous disease in a 2-month-old infant Reviewed

    Hirosuke Inoue, Takayuki Hoshina, Tadamune Kinjo, Mitsumasa Saito, Koichi Kusuhara, Toshiro Hara

    Pediatrics International   52 ( 2 )   2010.4

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    DOI： 10.1111/j.1442-200X.2010.03044.x

  • Central retinal artery occlusion following transcatheter balloon aortic valvuloplasty in an adolescent with aortic valvular stenosis Reviewed

    Hirosuke Inoue, Jun Muneuchi, Takuro Ohno, Aiko Arikawa, Tatsuro Ishibashi, Toshiro Hara

    Pediatric Cardiology   29 ( 4 )   830 - 833   2008.7

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    DOI： 10.1007/s00246-007-9181-0

  • 左大腿切断後にTSST-1産生MRSA感染によるToxic shock syndrome(TSS)様発疹症を呈した2ヵ月女児例

    井上 普介, 保科 隆之, 齋藤 光正, 楠原 浩一, 原 寿郎

    日本小児科学会雑誌   111 ( 7 )   918 - 918   2007.7

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  • 多関節炎を合併した全身型膿疱性乾癬の1女児例

    齋藤 光正, 井上 普介, 原 卓也, 服部 さがの, 保科 隆之, 高田 英俊, 楠原 浩一, 原 寿郎, 師井 洋一, 国場 尚志, 古江 増隆

    日本小児皮膚科学会雑誌   24 ( 2 )   183 - 183   2005.11

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  • Corrigendum to ‘Changing risk factors for postpartum depression in mothers admitted to a perinatal center’ [Pediatrics and Neonatology 64 (2023) 319–326, (S187595722200256X), (10.1016/j.pedneo.2022.09.013)]

    Sakemi Y., Nakashima T., Watanabe K., Ochiai M., Sawano T., Inoue H., Kawakami K., Isomura S., Yamashita H., Ohga S.

    Pediatrics and Neonatology   2024   （ ISSN:18759572 ）

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    This article [2023;64(3):319–326] titled “Changing risk factors for postpartum depression in mothers admitted to a perinatal center”, published in this journal, has a mistake. In 2.1. Study population: Line 7, “Fifty-seven mothers” should be corrected to “Forty-eight mothers”. In 3.1. Clinical features: Line 9, “The mean and standard deviation (SD)EPDS-J scores were 5.03 ± 0.12 within the first week and 3.79 ± 0.10 at the fourth week.” should be corrected to “The mean and standard deviation (SD)EPDS-J scores were 5.03 ± 4.45 within the first week and 3.79 ± 3.75 at the fourth week.” The authors apologize for this oversight. The authors would like to apologize for any inconvenience caused.

    DOI： 10.1016/j.pedneo.2024.08.002

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  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常　鉄過剰症　新生児鉄過剰症

    坂口 嘉彬, 井上 普介, 大賀 正一

    日本臨床   別冊 ( 血液症候群I )   512 - 516   2023.9   （ ISSN:0047-1852 ）

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    Language：Japanese   Publisher：(株)日本臨床社  

  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常　貧血　その他の貧血　未熟児貧血

    隈本 大智, 井上 普介, 大賀 正一

    日本臨床   別冊 ( 血液症候群I )   415 - 419   2023.9   （ ISSN:0047-1852 ）

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    Language：Japanese   Publisher：(株)日本臨床社  

  • 【周産期医療のヒヤリ・ハット-医療事故・医療紛争を防ぐために　新生児編】医療技術に関するもの　検体間違い

    井上 普介, 澤野 徹, 落合 正行

    周産期医学   53 ( 7 )   1106 - 1108   2023.7   （ ISSN:0386-9881 ）

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    Language：Japanese   Publisher：(株)東京医学社  

  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 2 )   51 - 58   2023.3   （ ISSN:0916-8796 ）

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    Language：Japanese   Publisher：日本産婦人科・新生児血液学会  

    新生児期の血栓症は希少な事例と考えられてきたが、医療の高度化と疾患認識の広がりにより報告数が増加している。さらに、日本人小児の血栓性素因における遺伝性プロテインC欠乏症の重要性が示されてきた。今回私たちは新生児血栓症の全国調査を行い、遺伝性プロテインC欠乏症の遺伝学的効果と、遺伝学的検査の悉皆性を示すことができた。今後は調査対象を小児から成人に達するまでに拡大し、小児患者とその家族を血栓症から守る個別化医療の確立を目指す。(著者抄録)

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  • 血栓性素因スクリーニングの臨床的意義　新生児血栓症の全国調査からの洞察

    江上 直樹, 落合 正行, 市山 正子, 井上 普介, 園田 素史, 石村 匡崇, 堀田 多恵子, 内海 健, 康 東天, 大賀 正一

    日本産婦人科・新生児血液学会誌   32 ( 2 )   51 - 58   2023.3   （ ISSN:0916-8796 ）

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    Language：Japanese   Publisher：日本産婦人科・新生児血液学会  

    新生児期の血栓症は希少な事例と考えられてきたが、医療の高度化と疾患認識の広がりにより報告数が増加している。さらに、日本人小児の血栓性素因における遺伝性プロテインC欠乏症の重要性が示されてきた。今回私たちは新生児血栓症の全国調査を行い、遺伝性プロテインC欠乏症の遺伝学的効果と、遺伝学的検査の悉皆性を示すことができた。今後は調査対象を小児から成人に達するまでに拡大し、小児患者とその家族を血栓症から守る個別化医療の確立を目指す。(著者抄録)

  • 新生児単純ヘルペスウイルス感染症の治療指針と課題

    園田 素史, 石村 匡崇, 市山 正子, 藤吉 順子, 井上 普介, 落合 正行, 大賀 正一

    日本産婦人科・新生児血液学会誌   31 ( 2 )   115 - 123   2022.3   （ ISSN:0916-8796 ）

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    Language：Japanese   Publisher：日本産婦人科・新生児血液学会  

    新生児単純ヘルペスウイルス(HSV)感染症は、主に垂直感染によって発症する重要な周産期感染症の一つである。臨床病型は表在型(SEM;skin, eye, and mouth)、中枢神経型(CNS;central nervous system)および全身型(Disseminated)の3つに分類され、それぞれ異なる症状と臨床経過を示す。1970年代以降、抗ウイルス薬の登場、またHSV-DNAを検出するPCR法の開発により、早期診断・治療が可能となり飛躍的に治療成績は改善した。しかし新生児医療が高度化した現代においても、全身型の新生児死亡率は29%、中枢神経型は65%以上に神経学的後遺症を残し、依然として予後不良の疾患である。本稿では新生児HSV感染症に対する治療指針と現在の課題について提示する。また新生児ヘルペス脳炎や新生児HSV関連血球貪食性リンパ組織球症といった重症例のリスク因子や治療戦略についても概説する。(著者抄録)

  • 生後1年間の身体発育と精神神経発達遅滞の関連:子どもの健康と環境に関する調査(エコチル調査)

    實藤雅文, 實藤雅文, 園田有里, 園田有里, 伊藤善也, 小川昌宣, トカン ヴラッド, 井上普介, 落合正行, 下野昌幸, 下野昌幸, 菅礼子, 千手絢子, 本荘哲, 楠原浩一, 楠原浩一, 大賀正一, 大賀正一

    日本疫学会学術総会講演集(Web)   32nd   2022

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  • ハイリスク早産児の神経学的予後 当院での9年間の前向き追跡研究

    鳥尾 倫子, 岩山 真理子, 澤野 徹, 井上 普介, 落合 正行, 平良 遼志, 米元 耕輔, 一宮 優子, 園田 有里, 笹月 桃子, 石崎 義人, 實藤 雅文, 山根 謙一, 山下 洋, 鳥巣 浩幸, 吉良 龍太郎, 原 寿郎, 神庭 重信, 酒井 康成, 大賀 正一

    日本小児科学会雑誌   2021.2

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    Language：Japanese  

  • 18トリソミー児の無呼吸に対する管理と予後

    平良 遼志, 井上 普介, 澤野 徹, 藤吉 順子, 一宮 優子, 鳥尾 倫子, 落合 正行, 實藤 雅文, 酒井 康成, 大賀 正一

    日本小児科学会雑誌   2021.2

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    Language：Japanese  

  • Postnatal Cytomegalovirus Infection-Associated Hemolytic Anemia in an Infant Born to a Lupus Mother

    Shunsuke Yamamoto, Masataka Ishimura, Keisuke Taku, Yutaro Yada, Katsuhide Eguchi, Wakato Matsuoka, Akira Shiraishi, Hirosuke Inoue, Masayuki Ochiai, Shouichi Ohga

    PEDIATRIC BLOOD & CANCER   2020.12

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    Language：English  

  • ハイリスク早産児に合併するてんかんの特徴

    鳥尾 倫子, 岩山 真理子, 井上 普介, 落合 正行, 平良 遼志, 米元 耕輔, 一宮 優子, 園田 有里, 實藤 雅文, 鳥巣 浩幸, 吉良 龍太郎, 酒井 康成, 大賀 正一

    てんかん研究   2020.9

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    Language：Japanese  

  • 18トリソミー児の無呼吸に対する管理と予後

    平良 遼志, 井上 普介, 澤野 徹, 藤吉 順子, 一宮 優子, 鳥尾 倫子, 落合 正行, 實藤 雅文, 酒井 康成, 大賀 正一

    日本小児科学会雑誌   2020.9

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    Language：Japanese  

  • Kleefstra症候群および多彩な臨床徴候を示した日本人家系の3例

    鳥尾 倫子, 礒部 菜摘, 一宮 優子, 井上 普介, 園田 有里, 實藤 雅文, 酒井 康成, 鳥巣 浩幸, 大賀 正一

    脳と発達   2020.8

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    Language：Japanese  

  • 出生時より咽頭喉頭機能不全を呈しGLE1変異が同定された乳児例

    山本 俊亮, 平良 遼志, 碇 航太, 井上 普介, 落合 正行, 賀来 典之, 米元 耕輔, 一宮 優子, 園田 有里, 鳥尾 倫子, 實藤 雅文, 酒井 康成, 吉浦 孝一郎, 大賀 正一

    脳と発達   2020.5

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    Language：Japanese  

  • 18トリソミー児の無呼吸に対する管理と予後

    井上 普介, 澤野 徹, 藤吉 順子, 金城 唯宗, 落合 正行, 平良 遼志, 酒井 康成, 大賀 正一

    日本新生児成育医学会雑誌   2019.10

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    Language：Japanese  

  • 18トリソミー児の無呼吸に対する管理と予後

    井上 普介, 江上 直樹, 安岡 和昭, 澤野 徹, 市山 正子, 藤吉 順子, 落合 正行, 平良 遼志, 酒井 康成, 大賀 正一

    日本周産期・新生児医学会雑誌   2019.6

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    Language：Japanese  

  • 無呼吸を呈する18トリソミー児に対する管理と予後

    平良 遼志, 井上 普介, 川上 沙織, 園田 有里, 一宮 優子, 鳥尾 倫子, 石崎 義人, 落合 正行, 實藤 雅文, 酒井 康成, 大賀 正一

    脳と発達   2019.5

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    Language：Japanese  

  • 新生児と小児における臨床検査のピットフォール

    落合 正行, 井上 普介, 大賀 正一

    臨床病理   2019.3

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    Language：Japanese  

  • NRNデータベースから示される極低出生体重児の気管切開の危険因子

    倉田 浩昭, 落合 正行, 井上 普介, 市山 正子, 安岡 和昭, 藤吉 順子, 松下 悠紀, 酒井 康成, 大賀 正一

    日本小児科学会雑誌   2018.2

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    Language：Japanese  

  • 九州における家族性血球貪食症候群(FHL)の現状

    園田 素史, 井上 普介, 市山 正子, 藤吉 順子, 落合 正行, 江口 克秀, 白石 暁, 石村 匡崇, 高田 英俊, 大賀 正一, 興梠 雅彦, 松本 志郎, 橋本 邦夫

    日本新生児成育医学会雑誌   2017.10

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  • 早産極低出生体重児における3歳時てんかん発症率と周産期危険因子

    松下 悠紀, 安岡 和昭, 田中 幸一, 菅 秀太郎, 倉田 浩昭, 井上 普介, 藤吉 順子, 落合 正行, 大賀 正一, 酒井 康成

    日本新生児成育医学会雑誌   2016.11

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    Language：Japanese  

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Professional Memberships

  • 日本小児科学会

  • 日本新生児成育医学会

  • 日本周産期新生児学会

  • 日本人類遺伝学会会

  • 日本小児神経学会

  • 日本人類遺伝学会会

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  • 日本周産期新生児学会

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  • 日本小児神経学会

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  • 日本小児科学会

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  • 日本新生児成育医学会

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Research Projects

  • ダウン症候群のTAMに合併する肝不全の発症と重症化の病態解明

    Grant number：24K11023  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    井上 普介, 古賀 友紀, 落合 正行

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    Grant type：Scientific research funding

    ダウン症候群児の約10%が出生時に一過性骨髄異常増殖症（transient abnormal myelopoiesis; TAM）を合併し、さらにそのうち約15%が乳児期早期死亡する。死亡原因の約半数は肝線維症による肝不全である。芽球数の多いTAMでは少量AraC治療にて死亡リスクが減少するが、芽球が少なくても肝不全を発症する例や、芽球が消失後にも肝不全が重症化する例があり、一度発症した肝不全に対しては有効な治療法は無い。申請者らは予備調査から、特定のケモカインが肝不全の発症と重症化に関与している可能性を見出したことから、TAMによる肝不全の発症と重症化の病態を解明して、予防と治療に介入可能な標的を絞り込む研究を行う。

    CiNii Research

  • 極低出生体重児が患う合併症に影響する血栓性素因の探索

    Grant number：22K07916  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    落合 正行, 井上 普介, 澤野 徹, 石村 匡崇, 藤吉 順子

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    Grant type：Scientific research funding

    未熟児動脈管開存症、頭蓋内出血・脳室周囲白質軟化、壊死性腸炎、未熟児網膜症および気管支肺異形成は、極低出生体重児の主要合併症であり、救命と予後に影響する。これらの病態には、血管新生と血栓傾向が関与する。血栓形成には環境要因と血栓性素因の影響を受けて複合的に作用する。研究代表者らは新生児期の血栓性素因を網羅的に検索する遺伝子パネル検査を試作し、診断未確定の血栓症新生児で測定したところ、過去に報告がない血管障害に関連する遺伝子変異を検出した。遺伝性血栓症には抗凝固療法や補充療法で治療可能な疾患が含まれる。本研究により合併症ハイリスクが早期診断され、遺伝子特異的な新規治療法の適応が期待できる。

    CiNii Research

  • 血管病変に着目した早産児気管支肺異形成症の病態解明

    Grant number：20K08231  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    井上 普介, 藤吉 順子, 落合 正行

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    Authorship：Principal investigator  Grant type：Scientific research funding

    周産期医療の進歩により早産児の救命率は著しく改善したが、早産児の重要な呼吸器合併症
    である気管支肺異形成（bronchopulmonary dysplasia; BPD）は在胎28週未満の早産児では増加傾向である。研究代表者らの研究および既報では、妊娠週数に比較して低出生体重であるSGA（small-for-gestational age）児は出生前より血管病変を有し、またBPDの合併率も高いことが明らかとなった。本研究の目的は、BPDの発症や重症化に早産児の血管病変が関連し、血管病変がSGA児でBPD発症率が高い要因であるという、新しい仮説を検証することである。

    CiNii Research

  • Development of screening method for neonatal hereditary protein C deficiency and application to thrombotic disease

    Grant number：18K07849  2018 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ichiyama Masako

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    Grant type：Scientific research funding

    Most neonatal hereditary thrombosis is protein C deficiency. However, it is difficult to diagnose from the activity value in the neonatal period. In this study, we accumulated the clinical features and activity levels of 41 neonatal-onset protein C deficiencies with genetic testing (19 biallelic mutations, 9 monoallelic mutations, and 13 no mutations) . Moreover, a prediction formula for gene mutation detection was developed using the protein C activity value and the protein C/protein S activity ratio.
    In addition, a nationwide survey of neonatal thrombosis was conducted. Five of 9 patients with protein C gene mutations had monoallelic mutations, and the genetic effects of monoallelic mutations were recognized. Seventy-five percent of the patients developed within 3 days of age (including the fetal period) regardless of the presence or absence of the mutation, suggesting the importance of early diagnosis and early treatment.

    CiNii Research

  • 胎児子宮内発育遅延の病因病態に関する研究 －血管炎との関連について－

    Grant number：17K16300  2017 - 2020

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 新生児気管支肺異形成BPD重症化因子の検索と炎症特異的な治療戦略の開発

    Grant number：15K09717  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

  • 胎児子宮内発育遅延の新しい病因・病態としての自然免疫受容体Nod1の解析

    Grant number：15K19656  2015 - 2016

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 近赤外線スペクトロスコピーを用いた早産児の脳活動と発達特性の相関分析

    Grant number：26860848  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

  • 小児期急性脳症の早期診断および予後予測に関する多施設共同研究

    Grant number：21591389  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

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Class subject

  • 総合医学I

    2018.4 - 2018.9   First semester

  • 総合医学I

    2017.4 - 2017.9   First semester

  • 受胎成長発達

    2016.4 - 2016.9   First semester

  • 総合医学I

    2016.4 - 2016.9   First semester

  • 受胎成長発達

    2015.4 - 2015.9   First semester

  • 総合医学I

    2015.4 - 2015.9   First semester

  • 受胎成長発達

    2014.4 - 2014.9   First semester

  • 総合医学I

    2014.4 - 2014.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • なし

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Pediatrics

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Fetal and Neonatal Medicine

Clinician qualification

  • Specialist

    Japan Pediatric Society

  • Specialist

    Japan Society of Perinatal and Neonatal Medicine

  • Specialist

    The Japan Society of Human Genetics

Year of medical license acquisition

  • 2003

Notable Clinical Activities

  • 2018年より総合周産期母子医療センター新生児内科部門の部門長およびリスクマネージャーとして、NICU・GCU病棟における診療、教育、医療安全の全般に携わっている。2022年からは小児科全体の運営管理、勤務管理、研究室管理を行っている。