Language：English   Publisher：Neonatology  

Introduction: Infants born extremely preterm are at high risk for neurodevelopmental problems. However, their neurodevelopment exhibits a variety of trajectories. This study aimed to investigate the association between changes in neurodevelopmental outcomes and clinical characteristics among extremely preterm infants. Methods: This is a retrospective study of surviving children born at gestational age 22-28weeks in Kyushu University Hospital between 2010 and 2020. We collected perinatal and post-discharge data and investigated the association between clinical characteristics and changes in developmental quotient (DQ) scores between 1.5 and 3 years of corrected age. Results: Out of the 179 eligible extremely preterm infants, 115 (64%) underwent neurological evaluations at 1.5 and 3 years of corrected age. Among them, 33 (29%) showed improvement in their DQ scores (+10 or more), 62 (54%) showed no change (-9 to +9), and 20 (17%) showed a decline (-10 or less). Gestational age, birth weight, and perinatal complications during the NICU stay did not affect individual changes in DQ scores. Multivariable analysis revealed that greater growth in height until age 3 years was a significant predictor of increasing DQ scores, while male sex and having siblings had a negative effect on changes in the DQ scores. Conclusion: We first demonstrate clinical data conceptualizing that growth in height, sex, and sibling status, rather than perinatal complications, are biologically linked with favorable or unfavorable neurodevelopmental changes of extremely preterm infants during the first 3 years of life.

DOI： 10.1159/000541129

Web of Science

Scopus

PubMed

Language：English   Publisher：Journal of Perinatology  

Objective: To examine erythroferrone (ERFE)-hepcidin iron regulation in premature infants under intensive care at risk of iron metabolic disorders. Study design: A retrospective cohort recruited 31 infants with a birth weight of <1500 g hospitalized in a tertiary center. Their hematological status was measured at birth and 2 and 4 weeks of life. Results: ERFE was positively correlated with the reticulocyte hemoglobin content at 2 (r2 = 0.2374) and 4 weeks (r2 = 0.6005). An assumed negative correlation between ERFE and hepcidin was not determined during the neonatal period. Hepcidin was positively correlated with the leukocyte count (r2 = 0.3089) and ferritin (r2 = 0.7476) at birth and C-reactive protein (r2 = 0.3591) at 2 weeks and negatively correlated with the reticulocyte count (r2 = 0.2887) at 4 weeks. Conclusion: The vulnerability of the ERFE-hepcidin pathway within 4 weeks may contribute to iron imbalance in premature infants.

DOI： 10.1038/s41372-021-01184-6

Web of Science

Scopus

PubMed

Event date： 2023.11

Language：Japanese   Presentation type：Symposium, workshop panel (public)  

Venue：アクロス福岡   Country：Japan  

エルシニア感染症とは，一般に腸炎エルシニア (Yersinia enterocolitica, YE)と偽結核菌 (Yersinia pseudotuberculosis, YPT）感染症を指す。YE感染症は胃腸炎症状を呈する。一方、発熱，発疹性疾患として、一部に川崎病の合併が知られている。川崎病は全身性血管炎を起こす原因不明の疾患である。川崎病は季節性や地域流行を来すことから、何らかの感染因子の関与が示唆されている。YPT感染患者の一部に川崎病様の症状を呈し、その血清中にYPTの菌体抽出物と同一物質を認めたことから、本菌が川崎病発症に関連する可能性が考えられている。川崎病症状を来したYPT株を含むゲノム、系統解析の報告はなく、そのゲノム背景は不明である。今回、国内から川崎病患者由来のYPT 株(KD株)を収集し系統解析、比較ゲノム解析を行った。ゲノムの観点からエルシニアと川崎病の関連について概説する。
目的 : 1. KD株とnon KD株の系統解析、比較ゲノム解析を行い、KD株の遺伝的特性を明らかにすることである。
方法 : 1. 国内で収集した35株のYPT株 (KD: 11株、non KD: 24株)のゲノムシーケンスを行い、公共DBから取得した日本株18株 (non KD株)、海外株124株 (KDの有無は不明)を加えた計187株に対し、コア遺伝子に基づく系統解析を行った。また、YPT187株のアクセサリ遺伝子を用いたゲノムワイド関連解析 (GWAS)を行い、KD株に特異的に保存される遺伝子を探索した。
結果 : 1. YPTの系統は分離された大陸に依存しており、最も祖先菌に近い系統にアジア株が存在した。また、KD株は特定の亜系統を形成せず、GWASによりKDと相関する遺伝子を同定することは困難であった。
考察 : KD株は特定の亜系統を形成せず、遺伝的多様性が示唆された。

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese   Publisher：(株)メディカ出版  

Language：Japanese   Publisher：(株)メディカ出版