Updated on 2024/07/28

Information

 

写真a

 
SAIWAI HIROKAZU
 
Organization
Kyushu University Hospital Orthopedic Surgery Assistant Professor
School of Medicine Department of Medicine(Joint Appointment)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425488
Profile
脊椎疾患の外来診療、手術に従事し、診療から新たな知見が得られるような臨床研究を進めていく。また、脊髄損傷の病態や治療に対する基礎研究を行っている。
External link

Degree

  • MD., PhD.

Research Interests・Research Keywords

  • Research theme:Spinal Organoid transplantation for spinal cord injury

    Keyword:spinal cord injury, organoid

    Research period: 2023.6

  • Research theme:Assessment of paraspinal muscle activity in adolescent idiopathic scoliosis.

    Keyword:scoliosis, paraspinal muscle, electromyography

    Research period: 2017.7 - 2019.7

  • Research theme:Assessment of physiological role of inflammatory cells after spinal cord injury

    Keyword:spinal cord injury, inflammatory cells, secondary injury

    Research period: 2010.4 - 2012.3

Papers

  • Development of a clinical prediction score for perioperative complications following metastatic spinal surgery (PERCOM) score. Reviewed International journal

    Takeuchi R, Tarukado K, Matsumoto Y, Iida KI, Kobayakawa K, Saiwai H, Kawaguchi K, Nakashima Y.

    Heliyon   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Verification of the Accuracy of Cervical Spinal Cord Injury Prognosis Prediction Using Clinical Data-Based Artificial Neural Networks. Reviewed International journal

    Kishikawa J, Kobayakawa K, Saiwai H, Yokota K, Kubota K, Hayashi T, Morishita Y, Masuda M, Sakai H, Kawano O, Nakashima Y, Maeda T.

    J Clin Med.   2024.1

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  • Metallothionein 3 promotes osteoclast differentiation and survival by regulating the intracellular Zn2+ concentration and NRF2 pathway. Reviewed International journal

    Arisumi S, Fujiwara T, Yasumoto K, Tsutsui T, Saiwai H, Kobayakawa K, Okada S, Zhao H, Nakashima Y.

    Cell Death Discov.   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Postoperative Time Course of Avulsion-Type Herniation Focused on the Development of New Modic Changes and Their Effect on Short-Term Residual Low Back Pain. Reviewed International journal

    Kawaguchi K, Saiwai H, Iida K, Kobayakawa K, Matsumoto Y, Harimaya K, Kato G, Nakashima Y.

    Global Spine J.   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Zinc deficiency impairs axonal regeneration and functional recovery after spinal cord injury by modulating macrophage polarization via NF-κB pathway. Reviewed International journal

    2023.11

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  • Dural reconstruction following resection of ventral and lateral spinal cord meningiomas: Fenestrated Durotomy with Oversized Graft technique. International journal

    Tarukado Kiyoshi, Matsumoto Yoshihiro, Yokota Kazuya, Kobayakawa Kazu, Saiwai Hirokazu, Kawaguchi Kenichi, Nakashima Yasuharu

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   116   120 - 124   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jocn.2023.09.003

  • Cases requiring reoperation for recurrence of myelopathy by lamina closure after a double-door laminoplasty using a modified Kirita-Miyazaki suture method. International journal

    Hideki Jimbayashi, Keiichiro Iida, Kobayakawa Kazu, Hirokazu Saiwai, Kenichi Kawaguchi, Yoshihiro Matsumoto, Yasuharu Nakashima

    Journal of orthopaedics   44   12 - 16   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jor.2023.07.024

  • Dural reconstruction following resection of ventral and lateral spinal cord meningiomas: Fenestrated Durotomy with Oversized Graft technique. Reviewed International journal

    Kiyoshi T, Yoshihiro M, Kazuya Y, Kazu K, Hirokazu S, Kenichi K, Yasuharu N.

    J Clin Neurosci.   2023.10

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  • Reduced Neuroinflammation Via Astrocytes and Neutrophils Promotes Regeneration After Spinal Cord Injury in Neonatal Mice. International journal

    Kazuki Kitade, Kazu Kobayakawa, Hirokazu Saiwai, Yoshihiro Matsumoto, Kenichi Kawaguchi, Keiichiro Iida, Ken Kijima, Hirotaka Iura, Tetsuya Tamaru, Yohei Haruta, Gentaro Ono, Daijiro Konno, Takeshi Maeda, Seiji Okada, Kinichi Nakashima, Yasuharu Nakashima

    Journal of neurotrauma   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/neu.2023.0044

  • Bimodal artificial intelligence using TabNet for differentiating spinal cord tumors-Integration of patient background information and images. Invited Reviewed International journal

    Kita K, Fujimori T, Suzuki Y, Kanie Y, Takenaka S, Kaito T, Taki T, Ukon Y, Furuya M, Saiwai H, Nakajima N, Sugiura T, Ishiguro H, Kamatani T, Tsukazaki H, Sakai Y, Takami H, Tateiwa D, Hashimoto K, Wataya T, Nishigaki D, Sato J, Hoshiyama M, Tomiyama N, Okada S, Kido S.

    iScience.   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. International journal

    Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Iura, Yohei Haruta, Kazuki Kitade, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima

    Scientific reports   13 ( 1 )   11177 - 11177   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-38301-8

  • Bone marrow-derived fibroblast migration via periostin causes irreversible arthrogenic contracture after joint immobilization. International journal

    Hirotaka Iura, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Masatake Tanaka, Kazuhiro Hata, Tetsuya Tamaru, Yohei Haruta, Gentaro Ono, Kazuki Kitade, Ken Kijima, Kensuke Kubota, Yutaka Inagaki, Masato Ohtsuka, Ken Okazaki, Koji Murakami, Shusaku Matsuda, Masami Tokunaga, Takaaki Yoshimoto, Takeshi Maeda, Yasuharu Nakashima, Seiji Okada

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology   37 ( 5 )   e22842   2023.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fj.202201598R

  • Destructive cervical spondylitis due to Cutibacterium acnes with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: A case report. International journal

    Ryunosuke Oyama, Keiichiro Iida, Hirokazu Saiwai, Yoshihiro Matsumoto, Yasuharu Nakashima

    Modern rheumatology case reports   7 ( 1 )   267 - 270   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/mrcr/rxac035

  • Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. International journal

    Gentaro Ono, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Lura, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, Makoto Tsuda, Tomohiko Tamura, Keiko Ozato, Kazuhide Inoue, Dai-Jiro Konno, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima

    Research square   2023.1

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    Language:English  

    DOI: 10.21203/rs.3.rs-2427082/v1

  • Glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury. International journal

    Tetsuya Tamaru, Kazu Kobayakawa, Hirokazu Saiwai, Daijiro Konno, Ken Kijima, Shingo Yoshizaki, Kazuhiro Hata, Hirotaka Iura, Gentaro Ono, Yohei Haruta, Kazuki Kitade, Kei-Ichiro Iida, Ken-Ichi Kawaguchi, Yoshihiro Matsumoto, Kensuke Kubota, Takeshi Maeda, Seiji Okada, Yasuharu Nakashima

    Experimental neurology   359   114264 - 114264   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.expneurol.2022.114264

  • Shape Factor of the Spinal Cord: A Possible Predictor of Surgical Outcome for Intradural Extramedullary Spinal Tumors in the Thoracic Spine. International journal

    Yoshihiro Matsumoto, Hirokazu Saiwai, Keiichiro Iida, Seiji Okada, Makoto Endo, Nokitaka Setsu, Toshifumi Fujiwara, Kenichi Kawaguchi, Yasuharu Nakashima

    Global spine journal   12 ( 7 )   1462 - 1467   2022.9

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    DOI: 10.1177/2192568220982571

  • Zinc chelator treatment in crush syndrome model mice attenuates ischemia-reperfusion-induced muscle injury due to suppressing of neutrophil infiltration. International journal

    Yohei Haruta, Kazu Kobayakawa, Hirokazu Saiwai, Kazuhiro Hata, Tetsuya Tamaru, Hirotaka Iura, Gentaro Ono, Kazuki Kitade, Ken Kijima, Keiichiro Iida, Kenichi Kawaguchi, Yoshihiro Matsumoto, Kensuke Kubota, Takeshi Maeda, Dai-Jiro Konno, Seiji Okada, Yasuharu Nakashima

    Scientific reports   12 ( 1 )   15580 - 15580   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-19903-0

  • Long-term outcome after en bloc resection and reconstruction of the spinal column and posterior chest wall in the treatment of malignant tumors.

    Katsumi Harimaya, Yoshihiro Matsumoto, Kenichi Kawaguchi, Hirokazu Saiwai, Keiichiro Iida, Yasuharu Nakashima

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   27 ( 4 )   899 - 905   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jos.2021.03.017

  • Epidural Fat Tissue Is More Effective for Scar Prevention Than Conventional Subcutaneous Fat Grafting After Laminectomy in a Mouse Model. International journal

    Kazuhiro Hata, Kazu Kobayakawa, Hirokazu Saiwai, Tetsuya Tamaru, Hirotaka Lura, Yohei Haruta, Gentarou Ono, Kazuki Kitade, Takeshi Maeda, Yasuharu Nakashima, Seiji Okada

    Spine   47 ( 11 )   E485-E493   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0000000000004281

  • Clinical features of multiple spinal schwannomas without vestibular schwannomas.

    Katsumi Harimaya, Yoshihiro Matsumoto, Kenichi Kawaguchi, Seiji Okada, Hirokazu Saiwai, Akinobu Matsushita, Keiichiro Iida, Hiromi Kumamaru, Takeyuki Saito, Yasuharu Nakashima

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   27 ( 3 )   563 - 568   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jos.2021.02.014

  • Long-term outcomes of spinal meningioma resection with outer layer of dura preservation technique. Invited Reviewed International journal

    Saiwai H, Okada S, Hayashida M, Harimaya K, Matsumoto Y, Kawaguchi KI, Iida KI, Kobayakawa K, Yokota K, Maeda T, Tsuchiya K, Arizono T, Saito T, Nakaie K, Iwamoto Y, Nakashima Y.

    Journal of Clinical Neuroscience   2021.1

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  • Long-term outcomes of spinal meningioma resection with outer layer of dura preservation technique. International journal

    Hirokazu Saiwai, Seiji Okada, Mitsumasa Hayashida, Katsumi Harimaya, Yoshihiro Matsumoto, Ken-Ichi Kawaguchi, Kei-Ichiro Iida, Kazu Kobayakawa, Kazuya Yokota, Takeshi Maeda, Kuniyoshi Tsuchiya, Takeshi Arizono, Taichi Saito, Kazutoshi Nakaie, Yukihide Iwamoto, Yasuharu Nakashima

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   83   68 - 70   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jocn.2020.11.026

  • Surgery-related predictable risk factors influencing postoperative clinical outcomes for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: A multicenter retrospective study. Reviewed International journal

    Saiwai H, Okada S, Hayashida M, Harimaya K, Matsumoto Y, Kawaguchi KI, Kobayakawa K, Maeda T, Ohta H, Shirasawa K, Tsuchiya K, Terada K, Kaji K, Arizono T, Saito T, Fujiwara M, Iwamoto Y, Nakashima Y.

    Journal of Neurosurgery Spine   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Surgery-related predictable risk factors influencing postoperative clinical outcomes for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: a multicenter retrospective study. International journal

    Hirokazu Saiwai, Seiji Okada, Mitsumasa Hayashida, Katsumi Harimaya, Yoshihiro Matsumoto, Ken-Ichi Kawaguchi, Kazu Kobayakawa, Takeshi Maeda, Hideki Ohta, Kenzo Shirasawa, Kuniyoshi Tsuchiya, Kazumasa Terada, Kouzo Kaji, Takeshi Arizono, Taichi Saito, Masami Fujiwara, Yukihide Iwamoto, Yasuharu Nakashima

    Journal of neurosurgery. Spine   1 - 7   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2019.10.SPINE19831

  • Clinical results of carbon-ion radiotherapy with separation surgery for primary spine/paraspinal sarcomas.

    Yoshihiro Matsumoto, Akira Matsunobu, Kenichi Kawaguchi, Mistumasa Hayashida, Keiichiro Iida, Hirokazu Saiwai, Seiji Okada, Makoto Endo, Nokitaka Setsu, Toshifumi Fujiwara, Shingo Baba, Satoshi Nomoto, Yasuharu Nakashima

    International journal of clinical oncology   24 ( 11 )   1490 - 1497   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-019-01505-y

  • Post-carbon-ion radiotherapy vertebral pathological fractures in upper cervical primary malignant spinal tumors treated by occipito-cervical fusion. International journal

    Satoshi Baba, Yoshihiro Matsumoto, Kenichi Kawaguchi, Keiichiro Iida, Hirokazu Saiwai, Seiji Okada, Akira Matsunobu, Yoshiyuki Shioyama, Yasuharu Nakashima

    Archives of orthopaedic and trauma surgery   139 ( 11 )   1525 - 1531   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00402-019-03183-x

  • Clinical Results of Carbon-Ion Radiotherapy with Separation Surgery for Primary Spine/Paraspinal Sarcomas. Invited Reviewed International journal

    Matsumoto Y, Matsunobu A, Kawaguchi K, Hayashida M, Iida K, Saiwai H, Okada S, Endo M, Setsu N, Fujiwara T, Baba S, Nomoto S, Nakashima Y.

    International Journal of Clinical Oncology   2019.7

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  • Prone position surgery for a professional sumo wrestler with thoracic ossification of the posterior longitudinal ligament resulting in intraoperative brachial plexus injury by hypertrophic pectoral muscles. Reviewed International journal

    Saiwai H, Okada S, Kawaguchi KI, Saito T, Hayashida M, Matsushita A, Matsumoto Y, Nakashima Y.

    Journal of Clinical Neuroscience   2019.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Prone position surgery for a professional sumo wrestler with thoracic ossification of the posterior longitudinal ligament resulting in intraoperative brachial plexus injury by hypertrophic pectoral muscles. International journal

    Hirokazu Saiwai, Seiji Okada, Ken-Ichi Kawaguchi, Takeyuki Saito, Mitsumasa Hayashida, Akinobu Matsushita, Yoshihiro Matsumoto, Yasuharu Nakashima

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   63   227 - 230   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jocn.2019.01.047

  • Post-carbon-ion Radiotherapy Vertebral Pathological Fractures in Upper Cervical Primary Malignant Spinal Tumors Treated by Occipito-Cervical Fusion. Invited Reviewed International journal

    Baba S, Matsumoto Y, Kawaguchi K, Iida K, Saiwai H, Okada S, Matsunobu A, Shioyama Y, Nakashima Y.

    Archives of Orthopedic and Trauma Surgery   2019.4

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  • Clinical Outcome and Prognostic Factors of Malignant Spinal Dumbbell Tumors.

    Yoshihiro Matsumoto, Kenichi Kawaguchi, Jun-Ichi Fukushi, Makoto Endo, Nokitaka Setsu, Keiichiro Iida, Satoshi Baba, Hirokazu Saiwai, Akinobu Matsushita, Mitsumasa Hayashida, Seiji Okada, Yasuharu Nakashima

    Spine surgery and related research   2 ( 4 )   317 - 323   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.22603/ssrr.2018-0004

  • Clinical Outcome and Prognostic Factors of Malignant Spinal Dumbbell Tumors. Invited Reviewed International journal

    Matsumoto Y, Kawaguchi K, Fukushi J, Endo M, Setsu N, Iida K, Baba S, Saiwai H, Matsushita A, Hayashida M, Okada S, Nakashima Y.

    Spine Surgery and Related Research   2018.4

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  • Systemic neutrophil depletion modulates the migration and fate of transplanted human neural stem cells to rescure functional repair. Invited Reviewed International journal

    Nguyen HX, Hooshmand MJ, Saiwai H, Maddox J, Salehi A, Lakatos A, Nishi RA, Salazar D, Uchida N, Anderson AJ.

    Journal of Neuroscience   2017.9

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  • Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair. International journal

    Hal X Nguyen, Mitra J Hooshmand, Hirokazu Saiwai, Jake Maddox, Arjang Salehi, Anita Lakatos, Rebecca A Nishi, Desiree Salazar, Nobuko Uchida, Aileen J Anderson

    The Journal of neuroscience : the official journal of the Society for Neuroscience   37 ( 38 )   9269 - 9287   2017.9

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    DOI: 10.1523/JNEUROSCI.2785-16.2017

  • Clinical features and surgical management of rare cases of thoracic intraspinal cysts: Report of 3 cases Invited Reviewed International journal

    Saiwai H, Okada S, Miyazaki K, Nakano R, Iwamoto Y, Tsuchiya K.

    JOURNAL OF ORTHOPAEDIC SCIENCE   22 ( 3 )   578 - 582   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jos.2015.09.004

  • Clinical features and surgical management of rare cases of thoracic intraspinal cysts: Report of 3 cases.

    Hirokazu Saiwai, Seiji Okada, Kosei Miyazaki, Ryuji Nakano, Yukihide Iwamoto, Kuniyoshi Tsuchiya

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   22 ( 3 )   578 - 582   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jos.2015.09.004

  • Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans Invited Reviewed International journal

    Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S.

    SCIENCE TRANSLATIONAL MEDICINE   6 ( 256 )   2014.10

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  • Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans. International journal

    Kazu Kobayakawa, Hiromi Kumamaru, Hirokazu Saiwai, Kensuke Kubota, Yasuyuki Ohkawa, Junji Kishimoto, Kazuya Yokota, Ryosuke Ideta, Keiichiro Shiba, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Yukihide Iwamoto, Seiji Okada

    Science translational medicine   6 ( 256 )   256ra137   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scitranslmed.3009430

  • Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans. Invited Reviewed International journal

    Kobayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Kishimoto J, Yokota K, Ideta R, Shiba K, Tozaki-Saitoh H, Inoue K, Iwamoto Y, Okada S.

    Science Translational Medicine   2014.10

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  • Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord. International journal

    Hiromi Kumamaru, Hirokazu Saiwai, Kensuke Kubota, Kazu Kobayakawa, Kazuya Yokota, Yasuyuki Ohkawa, Keiichiro Shiba, Yukihide Iwamoto, Seiji Okada

    Stem cells (Dayton, Ohio)   31 ( 8 )   1535 - 47   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/stem.1404

  • Therapeutic Activities of Engrafted Neural Stem/Precursor Cells Are Not Dormant in the Chronically Injured Spinal Cord Invited Reviewed International journal

    Kumamaru H, Saiwai H, Kubota K, Kobayakawa K, Yokota K, Ohkawa Y, Shiba K, Iwamoto Y, Okada S.

    STEM CELLS   31 ( 8 )   1535 - 1547   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/stem.1404

  • Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury. International journal

    Hirokazu Saiwai, Hiromi Kumamaru, Yasuyuki Ohkawa, Kensuke Kubota, Kazu Kobayakawa, Hisakata Yamada, Takehiko Yokomizo, Yukihide Iwamoto, Seiji Okada

    Journal of neurochemistry   125 ( 1 )   74 - 88   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jnc.12135

  • Ly6C(+)Ly6G(-) Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury Invited Reviewed International journal

    Saiwai H, Kumamaru H, Ohkawa Y, Kubota K, Kobayakawa K, Yamada H, Yokomizo T, Iwamoto Y, Okada S.

    JOURNAL OF NEUROCHEMISTRY   125 ( 1 )   74 - 88   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jnc.12135

  • Neurological recovery is impaired by concurrent but not by asymptomatic pre-existing spinal cord compression after traumatic spinal cord injury. International journal

    Kensuke Kubota, Hirokazu Saiwai, Hiromi Kumamaru, Kazu Kobayakawa, Takeshi Maeda, Yoshihiro Matsumoto, Katsumi Harimaya, Yukihide Iwamoto, Seiji Okada

    Spine   37 ( 17 )   1448 - 55   2012.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0b013e31824ffda5

  • Neurological Recovery Is Impaired by Concurrent but Not by Asymptomatic Pre-existing Spinal Cord Compression After Traumatic Spinal Cord Injury Invited Reviewed International journal

    Kubota K, Saiwai H, Kumamaru H, Kobayakawa K, Maeda T, Matsumoto Y, Harimaya K, Iwamoto Y, Okada S.

    SPINE   37 ( 17 )   1448 - 1455   2012.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0b013e31824ffda5

  • Myeloperoxidase Exacerbates Secondary Injury by Generating Highly Reactive Oxygen Species and Mediating Neutrophil Recruitment in Experimental Spinal Cord Injury Invited Reviewed International journal

    Kubota K, Saiwai H, Kumamaru H, Maeda T, Ohkawa Y, Aratani Y, Nagano T, Iwamoto Y, Okada S.

    SPINE   37 ( 16 )   1363 - 1369   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0b013e31824b9e77

  • Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal cord injury. International journal

    Kensuke Kubota, Hirokazu Saiwai, Hiromi Kumamaru, Takeshi Maeda, Yasuyuki Ohkawa, Yasuaki Aratani, Tetsuo Nagano, Yukihide Iwamoto, Seiji Okada

    Spine   37 ( 16 )   1363 - 9   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0b013e31824b9e77

  • Chd2 interacts with H3.3 to determine myogenic cell fate. International journal

    Akihito Harada, Seiji Okada, Daijiro Konno, Jun Odawara, Tomohiko Yoshimi, Saori Yoshimura, Hiromi Kumamaru, Hirokazu Saiwai, Toshiaki Tsubota, Hitoshi Kurumizaka, Koichi Akashi, Taro Tachibana, Anthony N Imbalzano, Yasuyuki Ohkawa

    The EMBO journal   31 ( 13 )   2994 - 3007   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/emboj.2012.136

  • Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures. International journal

    Hiromi Kumamaru, Hirokazu Saiwai, Kazu Kobayakawa, Kensuke Kubota, Nico van Rooijen, Kazuhide Inoue, Yukihide Iwamoto, Seiji Okada

    Journal of neuroinflammation   9   116 - 116   2012.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1742-2094-9-116

  • Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury Invited Reviewed International journal

    Kumamaru H, Saiwai H, Ohkawa Y, Yamada H, Iwamoto Y, Okada S.

    JOURNAL OF CELLULAR PHYSIOLOGY   227 ( 4 )   1335 - 1346   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.22845

  • Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury. International journal

    Hiromi Kumamaru, Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Yukihide Iwamoto, Seiji Okada

    Journal of cellular physiology   227 ( 4 )   1335 - 46   2012.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.22845

  • Extradural nodular fasciitis arising in the spinal canal. International journal

    Kensuke Kubota, Seiji Okada, Takeshi Maeda, Yoshihiro Matsumoto, Akio Sakamoto, Katsumi Harimaya, Hirokazu Saiwai, Hiromi Kumamaru, Yoshinao Oda, Yukihide Iwamoto

    Spine   37 ( 2 )   E133-7   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/BRS.0b013e318224568a

  • Flow Cytometric Sorting of Neuronal and Glial Nuclei From Central Nervous System Tissue Invited Reviewed International journal

    Saiwai H, Okada S, Kumamaru H, Kubota K, Yamaguchi M, Iwamoto Y, Ohkawa Y.

    JOURNAL OF CELLULAR PHYSIOLOGY   226 ( 2 )   552 - 558   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.22365

  • Flow cytometric sorting of neuronal and glial nuclei from central nervous system tissue. International journal

    Seiji Okada, Hirokazu Saiwai, Hiromi Kumamaru, Kensuke Kubota, Akihito Harada, Masahiro Yamaguchi, Yukihide Iwamoto, Yasuyuki Ohkawa

    Journal of cellular physiology   226 ( 2 )   552 - 8   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.22365

  • Ossification of the Posterior Longitudinal Ligament of the Lumbar Spine: A Case Series Invited Reviewed International journal

    Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y.

    NEUROSCIENCE RESEARCH   67 ( 5 )   1311 - 1318   2010.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1227/NEU.0b013e3181ef2806

  • Ossification of the posterior longitudinal ligament of the lumbar spine: a case series. International journal

    Seiji Okada, Takeshi Maeda, Hirokazu Saiwai, Yasuyuki Ohkawa, Keiichiro Shiba, Yukihide Iwamoto

    Neurosurgery   67 ( 5 )   1311 - 8   2010.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1227/NEU.0b013e3181ef2806

  • Generation of a rat monoclonal antibody specific for heat shock cognate protein 70. International journal

    Masayuki Shiota, Hirokazu Saiwai, Saya Mun, Akihito Harada, Seiji Okada, Jun Odawara, Masako Tanaka, Hiroshi Iwao, Yasuyuki Ohkawa

    Hybridoma (2005)   29 ( 5 )   453 - 6   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2010.0024

  • The LTB4-BLT1 Axis Mediates Neutrophil Infiltration and Secondary Injury in Experimental Spinal Cord Injury Invited Reviewed International journal

    Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, Yokomizo T, Iwamoto Y, Okada S.

    AMERICAN JOURNAL OF PATHOLOGY   176 ( 5 )   2352 - 2366   2010.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2353/ajpath.2010.090839

  • The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. International journal

    Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Hiromi Kumamaru, Akihito Harada, Hideyuki Okano, Takehiko Yokomizo, Yukihide Iwamoto, Seiji Okada

    The American journal of pathology   176 ( 5 )   2352 - 66   2010.5

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    DOI: 10.2353/ajpath.2010.090839

  • Production of a rat monoclonal antibody specific for Myf5. International journal

    Akihito Harada, Seiji Okada, Jun Odawara, Hiromi Kumamaru, Hirokazu Saiwai, Mayumi Aoki, Mako Nakamura, Yuko Nishiyama, Yasuyuki Ohkawa

    Hybridoma (2005)   29 ( 1 )   59 - 62   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0066

  • Generation of a rat monoclonal antibody specific for Pax7. International journal

    Akihito Harada, Seiji Okada, Hirokazu Saiwai, Mayumi Aoki, Mako Nakamura, Yasuyuki Ohkawa

    Hybridoma (2005)   28 ( 6 )   451 - 3   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0039

  • Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis. International journal

    Akiko Oyamada, Hiori Ikebe, Momoe Itsumi, Hirokazu Saiwai, Seiji Okada, Kazuya Shimoda, Yoichiro Iwakura, Keiichi I Nakayama, Yukihide Iwamoto, Yasunobu Yoshikai, Hisakata Yamada

    Journal of immunology (Baltimore, Md. : 1950)   183 ( 11 )   7539 - 46   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.0902740

  • Generation of a rat monoclonal antibody specific for Brm. International journal

    Seiji Okada, Akihito Harada, Hirokazu Saiwai, Mako Nakamura, Yasuyuki Ohkawa

    Hybridoma (2005)   28 ( 6 )   455 - 8   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hyb.2009.0044

  • Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury? International journal

    Seiji Okada, Takeshi Maeda, Yasuyuki Ohkawa, Katsumi Harimaya, Hirokazu Saiwai, Hiromi Kumamaru, Yoshihiro Matsumoto, Toshio Doi, Takayoshi Ueta, Keiichiro Shiba, Yukihide Iwamoto

    Spine   34 ( 11 )   1148 - 52   2009.5

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    DOI: 10.1097/BRS.0b013e31819e3215

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Presentations

  • 脊椎転移後方固定術後のアライメント変化はスクリューのゆるみの原因となる

    幸博和、山本瑛裕、小早川和、樽角清志、横田和也、川口謙一、中島康晴

    第13回 九州MIST研究会  2024.2 

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    Event date: 2024.2

    Language:Japanese  

    Country:Japan  

  • 仙骨骨折骨接合術後にLumbosacral tunnel syndromeを来した1例

    幸 博和、川口謙一、岡田誠司、松下昌史、松本嘉寛、中島康晴

    第44回福岡脊椎外科フォーラム  2019.12 

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    Event date: 2019.12

    Language:Japanese  

    Country:Japan  

  • 胸腔鏡補助下肺部分切除術後に生じた胸腔内髄液漏に対し神経根結紮が有効であった1例

    石田彩乃、幸博和、齋藤武恭、林田光正、川口謙一、岡田誠司、松下昌史、豊川剛二、田川哲三、松本嘉寛、中島康晴

    第135回西日本整形災害外科学会  2019.6 

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    Event date: 2019.6

    Language:Japanese  

    Country:Japan  

  • 脊髄髄膜腫術後長期経過観察例(5年以上)における予後調査

    幸 博和、林田光正、川口謙一、岡田誠司、松下昌史、松本嘉寛、中島康晴

    第91回日本整形外科学会学術総会  2018.5 

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    Event date: 2019.6

    Language:Japanese  

    Country:Japan  

  • 術中体位は思春期特発性側弯症術後の胸椎後弯を規定する重要な因子である

    幸 博和、岡田誠司、播广谷勝三、桑原正成、川口謙一、林田光正、松下昌史、松本嘉寛、中島康晴

    第48回日本脊椎脊髄病学会学術集会  2019.4 

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    Event date: 2019.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

Professional Memberships

  • 日本整形外科学会

  • 日本脊椎脊髄病学会

  • 日本リハビリテーション学会

  • 日本側彎症学会

Research Projects

  • 慢性期脊髄損傷における脊髄オルガノイド移植による治療法の開発

    Grant number:22K09426  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 思春期特発性側弯症に伴う腰痛の特異的な発症メカニズムの解明

    Grant number:18K16665  2018 - 2020

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Orthopedic Surgery

Clinician qualification

  • Specialist

    The Japanese Orthopaedic Association(JOA)

  • Preceptor

    The Japanese Society for Spine Surgery and Related Research

Year of medical license acquisition

  • 2002

Notable Clinical Activities

  • 脊椎・脊髄疾患 脊柱変形による腰痛発症のメカニズムの解明