Updated on 2025/06/09

Information

 

写真a

 
KUROGI RYOTA
 
Organization
Kyushu University Hospital Neurosurgery Assistant Professor
School of Medicine Department of Medicine（Concurrent）
Title
Assistant Professor
Profile
脳血管障害を中心とした臨床及び基礎研究を行っている。 臨床では、脳血管内治療及び脳血管外科手術を主に行っている。
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Research Interests・Research Keywords

  • Research theme： clinical and basic research on cerebrovascular disease

    Keyword： cerebrovascular disease

    Research period： 2023.5

Awards

  • 第24回日本脳神経外科学会奨励賞

    2018.10   日本脳神経外科学会   Effect of treatment modality on in-hospital outcome in patients with subarachnoid hemorrhage: a nationwide study in Japan.

Papers

  • Carotid Endarterectomy With Shunt-A Stepwise Surgical Technique Demonstration for Trainees: 2-Dimensional Operative Video

    Matsuo, S; Kurogi, R; Hasegawa, T; Yoshida, H; Fujii, K

    OPERATIVE NEUROSURGERY   27 ( 2 )   243 - 243   2024.8   （ ISSN:2332-4252 eISSN:2332-4260 ）

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    Language：English   Publisher：Operative neurosurgery (Hagerstown, Md.)  

    DOI： 10.1227/ons.0000000000001094

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    PubMed

  • Controversial Topics　放射線治療後の頸動脈狭窄症に対する血行再建術の治療成績

    黒木 亮太, 有村 公一, 岩城 克馬, 高岸 創, 中溝 玲, 吉本 幸司

    The Mt. Fuji Workshop on CVD   41   99 - 103   2024.7   （ ISSN:0289-8438 ）

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    Language：Japanese   Publisher：The Mt. Fuji Workshop on CVD事務局  

    2014年1月～2023年4月に放射線治療後の頸動脈狭窄症(RI-CS)に対して当院で血行再建術を行った患者14例(男性13例、女性1例、中央値74歳)の16頸動脈を対象に、治療成績を評価した。頸動脈内膜剥離術(CEA)が5頸動脈、頸動脈ステント留置術(CAS)が11頸動脈に行われた。Magnetization prepared rapid gradient echo法を用いたプラーク/胸鎖乳突筋比が2以上の症例は16頸動脈中7頸動脈(44%)で、CEA群が2頸動脈、CAS群が5頸動脈であった。CEA群では周術期の合併症はなく、再狭窄や再治療も認めなかった。CAS群では30日以内の症候性の虚血性合併症が2頸動脈であり、1例は一過性脳虚血発作(TIA)であったが、1例は失語が残存し、mRS 0から3へと低下した。30日以降の脳卒中の再発は2頸動脈であったが、手術に関連した症例は1例であり、TIAであったためmRSの低下はなかった。50%以上の再狭窄例は4頸動脈であり、症候性であった2頸動脈は追加治療を要した。RI-CSに対する外科治療においては、プラーク性状や解剖学的条件などを症例ごとに検討し、適切な治療方針を選択することが重要と考えられた。

  • Ten-year national trends in in-hospital mortality and functional outcomes after intracerebral hemorrhage by age in Japan: J-ASPECT study

    Nakaoku, Y; Ogata, S; Ren, NC; Tanaka, T; Kurogi, R; Nishimura, K; Iihara, K

    EUROPEAN STROKE JOURNAL   9 ( 2 )   398 - 408   2024.6   （ ISSN:2396-9873 eISSN:2396-9881 ）

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    Language：English   Publisher：European Stroke Journal  

    Introduction: National-level data on trends in the prognosis of age-stratified patients with intracerebral hemorrhage (ICH) are lacking. This study aimed to assess time trends in in-hospital mortality and functional outcomes of ICH patients by sex and age, and to explore factors associated with changes in in-hospital mortality trend. Patients and methods: Using the largest nationwide, J-ASPECT stroke database in Japan, this serial cross-sectional study included ICH patients aged ⩾18 years who were hospitalized for non-traumatic ICH from April 2010 to March 2020. We examined trends in in-hospital mortality and functional outcomes using the modified Rankin Scale at discharge, as well as differences in in-hospital mortality change between age groups. Results: Among 262,399 ICH patients from 934 hospitals, crude in-hospital mortality showed a significant decreasing time trend (from 19.5% to 16.7%), and this trend was consistent across sex and age groups. In addition, differences in in-hospital mortality change over the 10-year study period were significant between male patients aged ⩾75 years and those aged ⩽64 years (−3.9% [95% confidence interval, −5.4 to −2.4] for 75–84 years; −4.1% [−6.3 to −1.9] for ⩾85 years). On the other hand, the proportion of dependent patients (mRS 3–5) at discharge increased from 52.0% to 54.9% over the 10-year study period. Conclusion: The in-hospital mortality of ICH patients improved, whereas the proportion of patients with dependent functional outcome at discharge increased, over the 10-year study period. Elucidating the mechanism underlying differences in in-hospital mortality reduction in men may provide insights into effective interventions in the future.

    DOI： 10.1177/23969873231222736

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  • A cavernous sinus dural arteriovenous fistula treated by direct puncture of the superior ophthalmic vein with craniotomy: illustrative case

    Iwaki, K; Arimura, K; Fukuda, S; Takagishi, S; Ido, K; Kurogi, R; Matsumoto, K; Nakamizo, A; Yoshimoto, K

    JOURNAL OF NEUROSURGERY-CASE LESSONS   6 ( 20 )   2023.11   （ eISSN:2694-1902 ）

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    Language：English   Publisher：Journal of Neurosurgery: Case Lessons  

    BACKGROUND The authors report a case of symptomatic cavernous sinus (CS) dural arteriovenous fistula (dAVF) that was successfully treated using direct puncture of the superior ophthalmic vein (SOV) with craniotomy. CS dAVF is commonly treated using transvenous embolization (TVE), with the most common access route via the inferior petrosal sinus (IPS). However, this route is sometimes unavailable because of an occluded, hypoplastic, aplastic, or tortuous IPS. The SOV is an alternative, albeit tortuous and long, route to the CS; therefore, direct SOV puncture is occasionally performed. Direct SOV puncture is mostly percutaneous; however, in this case, it was difficult because of subcutaneous SOV narrowing. OBSERVATIONS As the patient experienced increased intraocular pressure, decreased vision, and eye movement disorders, CS embolization was performed via direct puncture with a craniotomy because of other access difficulties. LESSONS Several reports have described CS dAVF in patients receiving endovascular treatment via direct SOV puncture using a transorbital approach. However, to the best of the authors’ knowledge, this is the first reported case of a CS dAVF treated using TVE with craniotomy. This approach is useful when the SOV cannot be reached intravenously and its distance from the epidermis is long.

    DOI： 10.3171/CASE23464

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  • Percutaneous transluminal angioplasty for persistent primitive hypoglossal artery stenosis: illustrative case

    Iwaki, K; Arimura, K; Fukuda, S; Takagishi, S; Kurogi, R; Nakamura, K; Nakamizo, A; Yoshimoto, K

    JOURNAL OF NEUROSURGERY-CASE LESSONS   6 ( 17 )   2023.10   （ eISSN:2694-1902 ）

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    Language：English   Publisher：Journal of Neurosurgery: Case Lessons  

    BACKGROUND We report a case of symptomatic, progressive stenosis of a persistent primitive hypoglossal artery (PPHA), which was successfully treated with percutaneous transluminal angioplasty (PTA) of the origin of the PPHA. The PPHA is a type of carotid-basilar anastomosis with an incidence of 0.02% to 0.10%. It originates from the internal carotid artery (ICA), passes through the hypoglossal canal, and merges with the basilar artery. In many cases, the ipsilateral vertebral artery is hypoplastic; therefore, PPHA stenosis causes cerebral infarction in the posterior circulation territory, as in this case. OBSERVATIONS The patient’s right PPHA had severe and progressive stenosis; therefore, he experienced cerebral infarction despite medical treatment. Therefore, PTA for the stenosis was performed, which ceased the recurrence of cerebral infarction and dizziness by improving blood flow in the posterior circulation. LESSONS Several reports have described ICA stenosis accompanied by PPHA or PPHA stenosis in patients receiving endovascular treatments. Almost all cases were nonprogressive, and the treatment procedure was stenting. However, in our case, the PPHA stenosis was progressive, and we performed PTA because the patient experienced resistance to antiplatelet drugs and had poor collateral flow.

    DOI： 10.3171/CASE23427

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  • Midline Suboccipital Unilateral Trans-Cerebellomedullary Fissure Approach for Clipping of Ruptured VA-PICA Aneurysm: Two-Dimensional Operative Video

    Matsuo S., Kurogi R., Motohara Y., Hasegawa T., Yoshida H., Fujii K.

    World Neurosurgery   172   2023.4   （ ISSN:18788750 ）

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    Publisher：World Neurosurgery  

    The vertebral artery-posterior inferior cerebellar artery (VA-PICA) aneurysm poses a technical challenge for microsurgical clipping due to its anatomical complexity, which requires dissection of lower cranial nerves. Endovascular treatment is regarded as a feasible first-line therapeutic option for VA-PICA aneurysm because it has an acceptable aneurysm occlusion rate and is less invasive. However, microsurgical clipping remains an effective treatment option. We present the case of a 62-year-old man who presented with subarachnoid hemorrhage (SAH) due to a ruptured VA-PICA aneurysm. Neuroradiologic examination revealed a 2–3 mm medially pointing left VA-PICA aneurysm with acute obstructive hydrocephalus due to massive SAH in the posterior cranial fossa. As the patient had acute obstructive hydrocephalus and a relatively small aneurysm, we selected clipping over endovascular treatment. Because the aneurysm was located close to the midline and anterolateral to the medulla oblongata, we approached it from the midline. A midline suboccipital craniotomy, C1 laminectomy, and drilling of the left condylar fossa were performed; a unilateral cerebellomedullary fissure opening was added; and the aneurysm was clipped. Postoperative neuroradiologic examinations revealed complete obliteration of the aneurysm. As shown in this video, unilateral cerebellomedullary fissure opening combined with adequate removal of the condylar fossa provides a wide operative field in the cerebellomedullary cistern while avoiding strong retraction of the cerebellum. We believe that this technique makes VA-PICA aneurysm clipping safe and successful. Patient consent was obtained to perform the surgery and to publish the surgical video (Video 1).

    DOI： 10.1016/j.wneu.2023.01.105

    Scopus

  • National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study

    Kurogi, R; Kada, A; Ogasawara, K; Nishimura, K; Kitazono, T; Iwama, T; Matsumaru, Y; Sakai, N; Shiokawa, Y; Miyachi, S; Kuroda, S; Shimizu, H; Yoshimura, S; Osato, T; Horie, N; Nagata, I; Nozaki, K; Date, I; Hashimoto, Y; Hoshino, H; Nakase, H; Kataoka, H; Ohta, T; Fukuda, H; Tamiya, N; Kurogi, A; Ren, N; Nishimura, A; Arimura, K; Shimogawa, T; Yoshimoto, K; Onozuka, D; Ogata, S; Hagihara, A; Saito, N; Arai, H; Miyamoto, S; Tominaga, T; Iihara, K

    BMJ OPEN   13 ( 4 )   e068642   2023.4   （ ISSN:2044-6055 ）

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    Language：English   Publisher：BMJ Open  

    Objectives To examine the national, 6-year trends in in-hospital clinical outcomes of patients with subarachnoid haemorrhage (SAH) who underwent clipping or coiling and the prognostic influence of temporal trends in the Comprehensive Stroke Center (CSC) capabilities on patient outcomes in Japan. Design Retrospective study. Setting Six hundred and thirty-one primary care institutions in Japan. Participants Forty-five thousand and eleven patients with SAH who were urgently hospitalised, identified using the J-ASPECT Diagnosis Procedure Combination database. Primary and secondary outcome measures Annual number of patients with SAH who remained untreated, or who received clipping or coiling, in-hospital mortality and poor functional outcomes (modified Rankin Scale: 3-6) at discharge. Each CSC was assessed using a validated scoring system (CSC score: 1-25 points). Results In the overall cohort, in-hospital mortality decreased (year for trend, OR (95% CI): 0.97 (0.96 to 0.99)), while the proportion of poor functional outcomes remained unchanged (1.00 (0.98 to 1.02)). The proportion of patients who underwent clipping gradually decreased from 46.6% to 38.5%, while that of those who received coiling and those left untreated gradually increased from 16.9% to 22.6% and 35.4% to 38%, respectively. In-hospital mortality of coiled (0.94 (0.89 to 0.98)) and untreated (0.93 (0.90 to 0.96)) patients decreased, whereas that of clipped patients remained stable. CSC score improvement was associated with increased use of coiling (per 1-point increase, 1.14 (1.08 to 1.20)) but not with short-term patient outcomes regardless of treatment modality. Conclusions The 6-year trends indicated lower in-hospital mortality for patients with SAH (attributable to better outcomes), increased use of coiling and multidisciplinary care for untreated patients. Further increasing CSC capabilities may improve overall outcomes, mainly by increasing the use of coiling. Additional studies are necessary to determine the effect of confounders such as aneurysm complexity on outcomes of clipped patients in the modern endovascular era.

    DOI： 10.1136/bmjopen-2022-068642

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  • National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study. Reviewed International journal

    Kurogi R, Kada A, Ogasawara K, Nishimura K, Kitazono T, Iwama T, Matsumaru Y, Sakai N, Shiokawa Y, Miyachi S, Kuroda S, Shimizu H, Yoshimura S, Osato T, Horie N, Nagata I, Nozaki K, Date I, Hashimoto Y, Hoshino H, Nakase H, Kataoka H, Ohta T, Fukuda H, Tamiya N, Kurogi AI, Ren N, Nishimura A, Arimura K, Shimogawa T, Yoshimoto K, Onozuka D, Ogata S, Hagihara A, Saito N, Arai H, Miyamoto S, Tominaga T, Iihara K; J-ASPECT Study Collaborators.

    BMJ Open.   2023.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Efficacy of combined use of a stent retriever and aspiration catheter in mechanical thrombectomy for acute ischemic stroke

    Okuda, T; Arimura, K; Matsuo, R; Tokunaga, S; Hara, K; Yamaguchi, S; Yoshida, H; Kurogi, R; Kameda, K; Ito, O; Tsumoto, T; Iihara, K; Mizokami, T; Uwatoko, T; Nishimura, A; Iwaki, K; Mizoguchi, M

    JOURNAL OF NEUROINTERVENTIONAL SURGERY   14 ( 9 )   892 - +   2022.9   （ ISSN:1759-8478 eISSN:1759-8486 ）

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    Language：English   Publisher：Journal of NeuroInterventional Surgery  

    Background The efficacy of combined stent retriever (SR) and aspiration catheter (AC; combined technique: CBT) use for acute ischemic stroke (AIS) is unclear. We investigated the safety and efficacy of single-unit CBT (SCBT)—retrieving the thrombus as a single unit with SR and AC into the guide catheter—compared with single use of either SR or contact aspiration (CA). Methods We analysed 763 consecutive patients who underwent mechanical thrombectomy for AIS between January 2013 and January 2020, at six comprehensive stroke centers. Patients were divided into SCBT and single device (SR/CA) groups. The successful recanalization with first pass (SRFP) and other procedural outcomes were compared between groups. Results Overall, 240 SCBT and 301 SR/CA (SR 128, CA 173) patients were analyzed. SRFP (modified Thrombolysis In Cerebral Infarction (mTICI) ≥2c, 43.3% vs 27.9%, p<0.001; mTICI 3, 35.8% vs 25.5%, p=0.009) and final mTICI ≥2b recanalization (89.1% vs 82.0%, p=0.020) rates were significantly higher, puncture-to-reperfusion time was shorter (median (IQR) 43 (31.5–69) vs 55 (38–82.2) min, p<0.001), and the number of passes were fewer (mean±SD 1.72±0.92 vs 1.99±1.01, p<0.001) in the SCBT group. Procedural complications were similar between the groups. In subgroup analysis, SCBT was more effective in women, cardioembolic stroke patients, and internal carotid artery and M2 occlusions. Conclusions SCBT increases the SRFP rate and shortens the puncture-to-reperfusion time without increasing procedural complications.

    DOI： 10.1136/neurintsurg-2021-017837

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  • Effects of case volume and comprehensive stroke center capabilities on patient outcomes of clipping and coiling for subarachnoid hemorrhage. Reviewed International journal

    Kurogi R, Kada A, Ogasawara K, Kitazono T, Sakai N, Hashimoto Y, Shiokawa Y, Miyachi S, Matsumaru Y, Iwama T, Tominaga T, Onozuka D, Nishimura A, Arimura K, Kurogi A, Ren N, Hagihara A, Nakaoku Y, Arai H, Miyamoto S, Nishimura K, Iihara K.

    J Neurosurg.   2020.3

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  • Clinical Characteristics of Patients with Embolic Stroke of Undetermined Source Treated by Endovascular Recanalization Therapy. Reviewed International journal

    Kurogi R, Tsumoto T, Miyazaki Y, Kuwashiro T, Yasaka M, Okada Y.

    Journal of Neuroendovascular Therapy.   2018.9

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  • Effect of treatment modality on in-hospital outcome in patients with subarachnoid hemorrhage: a nationwide study in Japan (J-ASPECT Study). Reviewed International journal

    Kurogi R, Kada A, Nishimura K, Kamitani S, Nishimura A, Sayama T, Nakagawara J, Toyoda K, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Matsuda S, Yoshimura S, Okuchi K, Suzuki A, Nakamura F, Onozuka D, Hagihara A, Iihara K, J-ASPECT Study Collaborators.

    J Neurosurg.   2018.5

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  • Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-5p co-overexpression in human mesenchymal stem cells. Reviewed International journal

    Kurogi R, Nakamizo A, Suzuki SO, Mizoguchi M, Yoshimoto K, Amano T, Amemiya T, Takagishi S, Iihara K.

    J Neurosurg.   2018.3

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  • Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin. Reviewed International journal

    Kurogi R, Nishimura K, Nakai M, Kada A, Kamitani S, Nakagawara J, Toyoda K, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Matsuda S, Yoshimura S, Okuchi K, Suzuki A, Nakamura F, Onozuka D, Ido K, Kurogi A, Mukae N, Nishimura A, Arimura K, Kitazono T, Hagihara A, Iihara K; J-ASPECT Study Collaborators.

    Neurology.   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • 放射線治療後の頚動脈狭窄症に対するCEA Invited Reviewed

    黒木　亮太, 佐野　徳隆, 飯原　弘二

    脳卒中の外科   2016.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Upregulation of tissue inhibitor of metalloproteinase-1 contributes to restoration of the extracellular matrix in the rabbit basilar artery during cerebral vasospasm after subarachnoid hemorrhage. Reviewed International journal

    Kurogi R, Kikkawa Y, Matsuo S, Nakamizo A, Mizoguchi M, Sasaki T.

    Brain Res.   2015.8

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    Language：English   Publishing type：Research paper (scientific journal)  

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Presentations

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MISC

Professional Memberships

  • 日本脳卒中学会

  • 日本脳卒中の外科学会

  • 日本脳神経血管内治療学会

  • 日本脳神経外科学会

Research Projects

  • microRNAを標的としたくも膜下出血後早期脳損傷における血液脳関門破綻の新規治療戦略

    Grant number：25K19937  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    黒木 亮太

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    Grant type：Scientific research funding

    CiNii Research

  • 血小板由来増殖因子修飾ナノ粒子を用いた脳血管障害の新規治療に関する研究

    Grant number：24K12225  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    有村 公一, 村田 正治, 黒木 亮太

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    Grant type：Scientific research funding

    脳血管障害において、血小板由来増殖因子シグナルは障害部位の周囲の周皮細胞（ペリサイト）において活性化され、血液脳関門・神経保護・血管新生・創傷治癒などに重要な役割を果たしている。我々は先行研究において、マウス脳梗塞モデルにplatelet-derived growth factor-BB (PDGF-BB)修飾ナノ粒子を経静脈的に投与することにより、脳梗塞体積が縮小し運動機能が改善することを明らかにした。
    脳血管障害は未だ我が国の寝たきりの原因第1位であり、その克服は喫緊の課題である。そこで本研究ではPDGF-BB修飾ナノ粒子を用いたDrug delivery system(DDS)を利用した新規脳血管障害治療の開発を目指す。

    CiNii Research

Educational Activities

  • ベッドサイドでは脳神経外科手術及び周術期管理についての学生教育を担当している。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Neurosurgery

Clinician qualification

  • Specialist

    The Japanese Society for Neuroendovascular Therapy（JSNET）

  • Preceptor

    The Japan Stroke Society

  • Preceptor

    The Japan Neurosurgical Society（JNS）

Year of medical license acquisition

  • 2007