Updated on 2025/05/14

Information

 

写真a

 
KOBAYASHI SATOSHI
 
Organization
Kyushu University Hospital Urology Lecturer
School of Medicine Department of Medicine(Concurrent)
Title
Lecturer

Research Areas

  • Life Science / Tumor diagnostics and therapeutics

  • Life Science / Urology

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Electron device and electronic equipment

Degree

  • Ph.D.

Research History

  • Kyushu University Department of Urology Instructor 

    2024.4 - Present

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  • Kyushu University Department of Urology Assistant Professor 

    2023.4 - 2024.3

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  • Harvard Medical School Radiology Research fellow 

    2021.4 - 2023.3

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    Country:United States

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Research Interests・Research Keywords

  • Research theme: Kidney cancer

    Keyword: Kidney cancer

    Research period: 2025

  • Research theme: Machine learning

    Keyword: Machine learning

    Research period: 2025

  • Research theme: Artificial intelligence

    Keyword: Artificial intelligence

    Research period: 2025

  • Research theme: Robotic surgery

    Keyword: Robotic surgery

    Research period: 2025

  • Research theme: Robotics

    Keyword: Robotics

    Research period: 2025

  • Research theme: Navigation

    Keyword: Navigation

    Research period: 2025

  • Research theme: Urology Medical-Engineering Collaboration Artificial Intelligence

    Keyword: Urology AI

    Research period: 2023.4 - 2033.5

Awards

  • UAA Young Leadership Program 2024 Award

    2024.9   UAA Young Leadership Program 2024 Award  

    Satoshi Kobayashi

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  • 第18回ヤングリサーチグラントアワード

    2024.4   日本泌尿器科学会   18th Young Research Grant Award

  • 18th Young Research Grant Award

    2024.4   apanese Urological Association  

    KOBAYASHI SATOSHI

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  • 第21回総会賞

    2020.11   日本泌尿器内視鏡・ロボティス学会   21st General Assembly Award

  • 第11回学会賞

    2020.11   日本泌尿器内視鏡・ロボティス学会   11th Society Award

  • 第71回日本泌尿器科学会西日本総会 ヤングリサーチコンテスト

    2019.11   日本泌尿器科学会   71st Japanese Urological Association West Japan General Assembly Young Research Contest

  • 研究奨励賞

    2019.9   九州内視鏡・ロボット外科手術研究会   Research Encouragement Award

  • 名誉賞

    2019.6   香港内視鏡学会   Honorary Award

  • 2019年度臨床応用研究賞・荻野賞

    2019.4   日本生体医工学会   Clinical Application Research Award, Ogino Award

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Papers

  • Explainable radiomics based on association of histopathological cell density and multiparametric MR radiomic features for high-risk stratification of prostate cancer patients

    Shibayama, Y; Arimura, H; Takayama, Y; Kinoshita, F; Takamatsu, D; Nishie, A; Kobayashi, S; Matsumoto, T; Shiota, M; Eto, M; Oda, Y; Ishigami, K

    MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE   2025.4   ISSN:1352-8661

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  • Feasibility of a new L43K ultrasound probe attachment for intraoperative laparoscopic ultrasonography in robot-assisted partial nephrectomy

    Satoshi Kobayashi, Ryu Nakadate, Shinichi Miyata, Keiji Tsukino, Jun Mutaguchi, Shohei Ueda, Takashi Matsumoto, Keisuke Monji, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto

    Current Urology   2025.2

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    DOI: 10.1097/CU9.0000000000000274

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  • Analysis of Tumor Immune Microenvironment in the Upper Tract Urothelial Carcinoma with Intravesical Recurrence

    Ito, D; Tanegashima, T; Okumura, G; Itahashi, K; Tsukahara, S; Mutaguchi, J; Goto, S; Kobayashi, S; Matsumoto, T; Shiota, M; Koyama, S; Nishikawa, H; Eto, M

    CANCER SCIENCE   116   55 - 55   2025.1   ISSN:1347-9032 eISSN:1349-7006

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  • Laparoscopic Retroperitoneal Lymph Node Dissection After Chemotherapy for Nonseminomatous Testicular Germ‐Cell Tumor at a Single Center

    Masaki Shiota, Tokiyoshi Tanegashima, Shigehiro Tsukahara, Jun Mutaguchi, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto

    Asian Journal of Endoscopic Surgery   18 ( 1 )   e13416   2025.1   ISSN:1758-5902 eISSN:1758-5910

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    DOI: 10.1111/ases.13416

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  • Independent validation of genetic risk model to progression after intravesical BCG therapy for NMIBC

    Nagakawa, S; Shiota, M; Tsukahara, S; Tanegashima, T; Ueda, S; Mutaguchi, J; Goto, S; Kobayashi, S; Matsumoto, T; Eto, M

    CANCER SCIENCE   116   1513 - 1513   2025.1   ISSN:1347-9032 eISSN:1349-7006

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  • Experience with Computer-Assisted Surgery in Urology

    Kobayashi Satoshi, Mutaguchi Jun, Tsukino Keiji, Eto Masatoshi

    Journal of Japan Society of Computer Aided Surgery   26 ( 3 )   276 - 280   2025   ISSN:13449486 eISSN:18845770

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    Language:Japanese   Publisher:The Japan Society of Computer Aided Surgery  

    DOI: 10.5759/jscas.26.276

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  • Laparoscopic Retroperitoneal Lymph Node Dissection After Chemotherapy for Nonseminomatous Testicular Germ-Cell Tumor at a Single Center(タイトル和訳中)

    Shiota Masaki, Tanegashima Tokiyoshi, Tsukahara Shigehiro, Mutaguchi Jun, Goto Shunsuke, Kobayashi Satoshi, Matsumoto Takashi, Eto Masatoshi

    Asian Journal of Endoscopic Surgery   18 ( 1 )   ases.13416 - ases.13416   2025   ISSN:1758-5902

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  • Impact of proton pump inhibitors on the efficacy of androgen receptor signaling inhibitors in metastatic castration-resistant prostate cancer patients. Reviewed International journal

    Tokiyoshi Tanegashima, Masaki Shiota, Shigehiro Tsukahara, Jun Mutaguch, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto

    The Prostate   84 ( 14 )   1329 - 1335   2024.10   ISSN:0270-4137 eISSN:1097-0045

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    BACKGROUND: Proton pump inhibitors (PPIs) are widely used due to their affordability and minimal severe side effects. However, their influence on the efficacy of cancer treatments, particularly androgen receptor signaling inhibitors (ARSIs), remains unclear. This study investigates the impact of PPI usage on the treatment outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: A total of 117 mCRPC patients were retrospectively analyzed and divided into two groups based on the concomitant use of PPI at the initiation of ARSI treatment: PPI+ (n = 38) and PPI- (n = 79). Patient characteristics, including age at ARSI treatment administered, prostate-specific antigen (PSA) value at ARSI treatment administered, International Society of Urological Pathology grade group at prostate biopsy, metastatic site at ARSI treatment administered, prior docetaxel (DTX) treatment, and type of ARSI (abiraterone acetate or enzalutamide) were recorded. Progression-free survival (PFS), overall survival (OS), and PSA response rates were compared between the two groups. Patients were further stratified by clinical background to compare PFS and OS between the two groups. RESULTS: The PPI- group exhibited significantly extended PFS and a trend toward improved OS. For PSA response (reduction of 50% or more from baseline), the rates were 62.3% and 45.9% in the PPI- group and the PPI+ group, respectively. For deep PSA response (reductions of 90% or more from baseline), the rates were 36.4% and 24.3% in the PPI- group and the PPI+ group, respectively. The effects were consistent across subgroups divided by prior DTX treatment and type of ARSI administered. CONCLUSIONS: The administration of PPIs appears to diminish the therapeutic efficacy of ARSIs in mCRPC patients. Further prospective studies are needed to confirm these findings and explore the biological mechanisms involved.

    DOI: 10.1002/pros.24769

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  • Optimization of Extended Pelvic Lymph Node Dissection Side for Prostate Cancer. International journal

    Masaki Shiota, Masaki Shimbo, Shigehiro Tsukahara, Tokiyoshi Tanegashima, Jun Mutaguchi, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Kazunori Hattori, Fumiyasu Endo, Masatoshi Eto

    Annals of surgical oncology   31 ( 13 )   8986 - 8992   2024.9   ISSN:1068-9265 eISSN:1534-4681

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    BACKGROUND: This study aimed to show the association between tumor location and laterality of positive lymph nodes by evaluating biopsy and magnetic resonance imaging (MRI) findings, and to optimize the extended pelvic lymph node dissection (ePLND) side for prostate cancer. METHODS: The study enrolled patients who underwent robot-assisted radical prostatectomy with ePLND. Tumor locations were determined according to International Society of Urological Pathology grade group 4/5 in biopsies and Prostate Imaging-Reporting and Data System category 4/5 in MRI results. The concordance of tumor location lobe and positive lymph node side with the performance of tumor location-guided ePLND for positive lymph node detection was evaluated. RESULTS: For 301 patients who underwent ePLND at Kyushu University Hospital, tumor locations determined by biopsy and MRI findings showed no lesion in 8 (2.7%) patients, unilateral lobe in 223 (74.1%) patients, and bilateral lobe in 70 (23.3%) patients. The accuracies for detection of any and all positive lymph nodes by tumor location-guided unilateral ePLND were 99.6% and 97.3%, respectively. Among the patients at St. Luke's International Hospital, the accuracies for detection of any and all positive lymph nodes by tumor location-guided unilateral ePLND were estimated to be 99.0% and 97.3%, respectively. CONCLUSIONS: This study proposed tumor location-guided ePLND according to biopsy and MRI findings. This novel strategy is expected to reduce the burden of bilateral ePLND at the cost of acceptable risk of failing to detect positive lymph nodes.

    DOI: 10.1245/s10434-024-16294-6

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  • Oxidative stress in peroxisomes induced by androgen receptor inhibition through peroxisome proliferator-activated receptor promotes enzalutamide resistance in prostate cancer. Reviewed International journal

    Masaki Shiota, Miho Ushijima, Shigehiro Tsukahara, Shohei Nagakawa, Tatsunori Okada, Tokiyoshi Tanegashima, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto

    Free radical biology & medicine   221   81 - 88   2024.8   ISSN:0891-5849 eISSN:1873-4596

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    Androgen receptor (AR)-targeting therapy induces oxidative stress in prostate cancer. However, the mechanism of oxidative stress induction by AR-targeting therapy remains unclear. This study investigated the mechanism of oxidative stress induction by AR-targeting therapy, with the aim to develop novel therapeutics targeting oxidative stress induced by AR-targeting therapy. Intracellular reactive oxygen species (ROS) was examined by fluorescence microscopy and flow cytometry analysis. The effects of silencing gene expression and small molecule inhibitors on gene expression and cytotoxic effects were examined by quantitative real-time PCR and cell proliferation assay. ROS induced by androgen depletion co-localized with peroxisomes in prostate cancer cells. Among peroxisome-related genes, PPARA was commonly induced by AR inhibition and involved in ROS production via PKC signaling. Inhibition of PPARα by specific siRNA and a small molecule inhibitor suppressed cell proliferation and increased cellular sensitivity to the antiandrogen enzalutamide in prostate cancer cells. This study revealed a novel pathway by which AR inhibition induced intracellular ROS mainly in peroxisomes through PPARα activation in prostate cancer. This pathway is a promising target for the development of novel therapeutics for prostate cancer in combination with AR-targeting therapy such as antiandrogen enzalutamide.

    DOI: 10.1016/j.freeradbiomed.2024.05.030

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  • Functional outcomes in robot-assisted partial nephrectomy with three-dimensional images reconstructed from computed tomography: a propensity score-matched comparative analysis. Reviewed International journal

    Satoshi Kobayashi, Keiji Tsukino, Jun Mutaguchi, Tokiyoshi Tanegashi, Shunsuke Goto, Takashi Matsumoto, Masaki Shiota, Masatoshi Eto

    Journal of robotic surgery   18 ( 1 )   314 - 314   2024.8   ISSN:1863-2483 eISSN:1863-2491

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Robotic Surgery  

    Our objective was to investigate the long-term functional outcomes of robot-assisted partial nephrectomy (RAPN) combined with three-dimensional (3D) imaging. The 3D images, reconstructed using computed tomography, were introduced in RAPN procedures. The demographic, oncological, functional, and volumetric outcomes of 296 patients who underwent RAPN with and without 3D imaging between 2013 and 2021 were analyzed retrospectively. Propensity score matching (1:1) was performed to adjust for potential baseline confounders. After matching, 71 patients were allocated to each group. In the 3D RAPN (3DRPN) group, functional outcomes significantly improved: the number of patients with over 90% estimated glomerular filtration rate (eGFR) preservation rate (40 vs. 43, P = 0.044), eGFR preservation rate (88.0% vs. 91.6%, P = 0.006), the number of patients with chronic kidney disease (CKD) upstaging (26 vs. 13, P = 0.023), and split renal function preservation rate (operated kidney: 84.9% vs. 88.5%, P = 0.015). The 3DRPN group showed superiority in terms of >90% eGFR preservation (P = 0.010), CKD upstaging-free survival rates (P < 0.001), and volumetric outcomes (excess parenchymal volume: 27.9 vs. 17.7 mL, P = 0.030; parenchyma volume preservation rate: 81.6% vs. 88.8%, P = 0.006). Three-dimensional imaging was positively associated with eGFR preservation (P = 0.023, odds ratio: 2.34) and prevention of CKD upstaging (P = 0.013, odds ratio: 2.90). In this study, RAPN combined with 3D imaging underscored the preservation of eGFR > 90% and the prevention of CKD upstaging by improving the preservation rate of renal parenchyma and split renal function.

    DOI: 10.1007/s11701-024-02070-x

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  • Current status and future perspective of immunotherapy for renal cell carcinoma

    Leandro Blas, Keisuke Monji, Jun Mutaguchi, Satoshi Kobayashi, Shunsuke Goto, Takashi Matsumoto, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto

    International Journal of Clinical Oncology   29 ( 8 )   1105 - 1114   2024.8   ISSN:1341-9625 eISSN:1437-7772

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    In the last decade, the standard treatment for advanced renal cell carcinoma (RCC) has evolved, mainly driven by the development and approval of immune checkpoint inhibitors (ICIs). Currently, ICI monotherapy and ICI-based combinations with tyrosine kinase inhibitors and targeted therapies against mammalian target of rapamycin or vascular endothelial growth factor have become new standard treatments for first-line and subsequent-line therapies. ICIs play an important role as an adjuvant postoperative therapy, and this field is the subject of active research. Furthermore, ongoing randomized controlled trials are investigating the clinical value of more intense treatments by combining multiple effective treatments for RCC. Additionally, novel biomarkers for prognosis have been investigated. This study reviews the current evidence on immunotherapy as a treatment for RCC patients, randomized controlled trials, and ongoing studies including RCC patients and recent findings, and discusses future perspectives.

    DOI: 10.1007/s10147-023-02446-3

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  • Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer. International journal

    Masaki Shiota, Satoshi Endo, Shigehiro Tsukahara, Tokiyosh Tanegashima, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto

    Endocrine-related cancer   31 ( 7 )   2024.7   ISSN:1351-0088 eISSN:1479-6821

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    Androgen receptor signaling is crucial for the development of treatment resistance in prostate cancer. Among steroidogenic enzymes, 3β-hydroxysteroid dehydrogenases (3βHSDs) play critical roles in extragonadal androgen synthesis, especially 3βHSD1. Increased expression of 3βHSDs is observed in castration-resistant prostate cancer tumors compared with primary prostate tumors, indicating their involvement in castration resistance. Recent studies link 3βHSD1 to resistance to androgen receptor signaling inhibitors. The regulation of 3βHSD1 expression involves various factors, including transcription factors, microenvironmental influences, and post-transcriptional modifications. Additionally, the clinical significance of HSD3B1 genotypes, particularly the rs1047303 variant has been extensively studied. The impact of HSD3B1 genotypes on treatment outcomes varies according to the therapy administered, suggesting the potential of HSD3B1 genotyping for personalized medicine. Targeting 3βHSDs may be a promising strategy for prostate cancer management. Overall, understanding the roles of 3βHSDs and their genetic variations may enable the development and optimization of novel treatments for prostate cancer.

    DOI: 10.1530/ERC-24-0023

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  • Survival beyond cabazitaxel for metastatic castration-resistant prostate cancer. International journal

    Leandro Blas, Masaki Shiota, Tokiyoshi Tanegashima, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto

    International journal of urology : official journal of the Japanese Urological Association   31 ( 7 )   829 - 831   2024.7   ISSN:0919-8172 eISSN:1442-2042

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    DOI: 10.1111/iju.15449

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  • 転移性去勢抵抗性前立腺癌に対するカバジタキセルとその他治療による生存期間(Survival beyond cabazitaxel for metastatic castration-resistant prostate cancer)

    Blas Leandro, Shiota Masaki, Tanegashima Tokiyoshi, Kobayashi Satoshi, Matsumoto Takashi, Eto Masatoshi

    International Journal of Urology   31 ( 7 )   829 - 831   2024.7   ISSN:0919-8172

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    転移性去勢抵抗性前立腺癌(mCRPC)に対するカバジタキセル後の治療パターンを評価し、生存への影響について検討した。2014~2023年にカバジタキセルによる治療を受けたmCRPC日本人患者を対象とした。全生存期間はカバジタキセル最終投与から死亡または最終追跡時点までとし、カプランマイヤー法により推定した。患者36例(カバジタキセル開始時、中央値72.5歳)を解析した。多くの患者がカバジタキセル治療前にアンドロゲン受容体シグナル伝達阻害薬(ARSI)やドセタキセルによる治療を受けた。36例中11例がカバジタキセル後に別の薬物治療を受けた。カバジタキセル後の追跡期間中央値4.27ヵ月に、33例(91.7%)が死亡した。12ヵ月全生存率は、カバジタキセル後に治療を受けた群で25.3%(95%CI:4.1~55.5)、受けなかった群で8%(同1.4~2.2)であった(p=0.0499)。カバジタキセル後に一次治療ARSI、オラパリブ、ラジウム223、またはドセタキセルを受けた患者と受けなかった患者の12ヵ月全生存率はそれぞれ50.0%(同11.1~80.4)と7%(同1.2~20.1)であった(p=0.0231)。以上より、mCRPCにおいてカバジタキセル後に治療を受けた患者では受けなかった患者よりも全生存期間が長いことが示された。

  • Validation of schedules for optimal prostate-specific antigen monitoring after radical prostatectomy International journal

    Leandro Blas, Masaki Shiota, Tokiyoshi Tanegashima, Shigehiro Tsukahara, Shohei Ueda, Jun Mutaguchi, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Junichi Inokuchi, Masatoshi Eto

    International Journal of Urology   31 ( 4 )   404 - 408   2024.4   ISSN:0919-8172 eISSN:1442-2042

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    Background: Early detection of biochemical recurrence (BCR) after radical prostatectomy (RP) is crucial for early treatment and improving survival outcomes. The optimal prostate-specific antigen (PSA) monitoring remains unclear, and several models have been proposed. We aimed to externally validate four models for optimal PSA monitoring after RP and propose modifications to improve them. Methods: We reviewed the clinicopathological data of 896 patients who underwent robot-assisted RP between 2009 and 2022. We examined all PSA values and estimated the PSA value for four monitoring schedules at each time point in the virtual follow-up. We defined the ideal PSA for BCR detection between 0.2 and 0.4 ng/mL. Results: During the median follow-up of 21.4 months, 128 (14.3%) patients presented BCR. The original and modified Keio models, National Cancer Center Hospital model, and American Urological Association/American Society for Radiation Oncology model detected BCR in 14 (10.9%), three (2.3%), 12 (9.4%), and 11 (8.6%) patients with PSA >0.4 ng/mL. Most patients experienced BCR detected with PSA >0.4 ng/mL during the first year postoperative. The modification of interval within 6 months postoperative avoided BCR detection with PSA >0.4 ng/mL within the first year postoperative in 8/9 (88.9%), 1/2 (50.0%), 5/6 (83.3%), and 4/4 (100%) for the original and modified Keio models, National Cancer Center Hospital model, and American Urological Association/American Society for Radiation Oncology model, respectively. Conclusion: We validated four models for PSA monitoring after RP to detect BCR and suggested modifications to avoid detections out of the desired range of PSA. These modifications could help to establish an optimal PSA monitoring schedule after RP.

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  • 根治的前立腺摘除術後の最適な前立腺特異抗原モニタリングスケジュールの検証(Validation of schedules for optimal prostate-specific antigen monitoring after radical prostatectomy)

    Blas Leandro, Shiota Masaki, Tanegashima Tokiyoshi, Tsukahara Shigehiro, Ueda Shohei, Mutaguchi Jun, Goto Shunsuke, Kobayashi Satoshi, Matsumoto Takashi, Inokuchi Junichi, Eto Masatoshi

    International Journal of Urology   31 ( 4 )   404 - 408   2024.4   ISSN:0919-8172

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    根治的前立腺摘除術(RP)後に行う前立腺特異抗原(PSA)モニタリングの4つのモデルの妥当性を検証し、生化学的再発(BCR)検出を改善する修正モデルを検討した。2009~2022年にロボット支援RPを受けた患者の臨床病理学的データを調べ、4つのモデルで仮想上経過観察時のPSA値を推定した。BCR検出に最適なPSA値は0.2~0.4ng/mLと定義した。患者896例(年齢中央値66歳)を解析した。追跡期間中央値21.4ヵ月の間に128例(14.3%)がBCRを認めた。BCRが検出されたPSA値0.4ng/mL超の患者は、慶應モデル、修正慶應モデル、国立がん研究センター中央病院(NCCH)モデル、および米国泌尿器科学会(AUA)/米国放射線腫瘍学会(ASTRO)モデルでそれぞれ14例(10.9%)、3例(2.3%)、12例(9.4%)、および11例(8.6%)であった。殆どの患者は、術後1年目にPSA値0.4ng/mL超でBCRが検出された。術後6ヵ月以内の間隔に変更すると、術後1年以内のPSA>0.4ng/mLのBCR検出は上記のモデルそれぞれで8/9例(88.9%)、1/2例(50.0%)、5/6(83.3%)、4/4例(100%)で回避された。以上より、RP後のBCR検出のためのPSAモニタリングを最適にするための修正案が示唆された。

  • An innovate segmentation system by implementing dilated convolution and red channel enhanced images in cystoscopic images

    Mutaguchi, J; Morooka, K; Goto, S; Kobayashi, S; Matsumoto, T; Shiota, M; Inokuchi, J; Eto, M

    EUROPEAN UROLOGY   85   S377 - S377   2024.3   ISSN:0302-2838 eISSN:1873-7560

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  • Salvage robot‐assisted radical prostatectomy after carbon ion radiotherapy to the prostate

    Masaki Shiota, Shigehiro Tsukahara, Dai Takamatsu, Tokiyoshi Tanegashima, Shohei Ueda, Leandro Blas, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Junichi Inokuchi, Yoshiyuki Shioyama, Masatoshi Eto

    Asian Journal of Endoscopic Surgery   17 ( 1 )   e13279   2024.1   ISSN:1758-5902 eISSN:1758-5910

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    PURPOSE: This study presents the surgical and oncological outcomes of salvage robot-assisted radical prostatectomy (RARP) after carbon ion radiotherapy at a single institution. METHODS: Patients who underwent salvage RARP for local recurrence after carbon ion radiotherapy at Kyushu University Hospital between 2020 and 2023 were included. A single surgeon performed salvage RARP with extended pelvic lymph node dissection. Clinicopathological characteristics and perioperative and postoperative outcomes were prospectively collected and electronically recorded. RESULTS: Ten cases were included. The preoperative clinical T-stage was T2, except for one case with T3a. The median console time was 171 min (range, 135-226 min). No severe perioperative or postoperative complications were noted. The pathological T-stage was T2, T3a, and T3b in four, four, and two cases, respectively. Biochemical recurrence was observed in one patient at 31.2 months after surgery. For patients with more than 1 year of follow-up, urinary continence recovery with ≤1 pad was achieved in two cases within 1 year, whereas four cases did not recover urinary continence within 1 year. CONCLUSIONS: This case series demonstrated the feasibility of salvage RARP after carbon ion radiotherapy. Although the urinary continence recovery was modest, short-term disease control was favorable.

    DOI: 10.1111/ases.13279

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  • Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy to the prostate. Reviewed International journal

    @Shiota M, @Tsukahara S, @Takamatsu D, @Tanegashima T, @Ueda S, #Blas L, @Goto S, @Kobayashi S, @Matsumoto T, @Inokuchi J, @Shioyama Y, @Eto M.

    Asian J Endosc Surg   2024.1

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  • 前立腺に対する炭素イオン線治療後のサルベージロボット支援前立腺全摘術(Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy to the prostate)

    Shiota Masaki, Tsukahara Shigehiro, Takamatsu Dai, Tanegashima Tokiyoshi, Ueda Shohei, Blas Leandro, Goto Shunsuke, Kobayashi Satoshi, Matsumoto Takashi, Inokuchi Junichi, Shioyama Yoshiyuki, Eto Masatoshi

    Asian Journal of Endoscopic Surgery   17 ( 1 )   ases.13279 - ases.13279   2024.1   ISSN:1758-5902

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    前立腺癌に対する炭素イオン線治療(CIRT)後のサルベージロボット支援前立腺全摘術(RARP)の手術アウトカムと腫瘍アウトカムについて検討した。2020~2023年に、CIRT後に局所再発をきたしてRARPを施行された前立腺癌患者10例(中央値69歳)を対象とした。拡大骨盤リンパ節郭清(PLND)によるサルベージRARPを行い、臨床病理学的特徴、周術期アウトカムおよび術後アウトカムを評価した。CIRT後の局所再発時のPSA中央値は4.02ng/mL、生検によるGleason分類ではグレードIIが1例、グレードIIIが2例、グレードIVが2例、グレードVが5例であり、術前の臨床的Tステージは9例がT2、1例のみT3a、初期診断から局所再発までは中央値58.5ヵ月であった。RARPに際して全例にPLND、1例に両側神経温存手術を行い、手術時間中央値は235分、コンソール時間中央値は171分、推定出血量中央値は150mLであった。直腸損傷といった周術期合併症や術後90日以内の再入院、尿道狭窄は認められなかった。腫瘍アウトカムに関して、1例が術後31.2ヵ月に生化学的再発を呈した。CIRT後に局所再発をきたした前立腺癌患者に対して、RARPは実行可能な手技であることが示された。

  • NR5A2/HSD3B1 pathway promotes cellular resistance to second-generation antiandrogen darolutamide. Reviewed International journal

    @Shiota M, @Ushijima M, @Tsukahara S, @Nagakawa S, #Blas L, @Takamatsu D, @Kobayashi S, @Matsumoto T, @Inokuchi J, @Eto M:

    Drug Resist Updat   2023.9

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  • Improved urinary continence recovery after robot-assisted radical prostatectomy with lateral pelvic fascia preservation. International journal

    Masaki Shiota, Shigehiro Tsukahara, Shohei Ueda, Jun Mutaguchi, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Leandro Blas, Keisuke Monji, Junichi Inokuchi, Masatoshi Eto

    Journal of robotic surgery   17 ( 6 )   2721 - 2728   2023.8   ISSN:1863-2483 eISSN:1863-2491

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    The novel technique of lateral pelvic fascia preservation (LPFP) in robot-assisted radical prostatectomy (RARP) has been reported to improve urinary continence recovery. We aimed to investigate surgical and oncological outcomes after RARP using the LPFP technique and compare them with conventional RARP. This study included patients who underwent RARP with and without the LPFP technique. Time to urinary continence recovery was compared between the LPFP and non-LPFP groups using univariate, multivariate, and propensity-score matched analysis. Perioperative and postoperative outcomes were compared between the two groups using univariate analysis. We included 139 patients who underwent RARP, 68 in the LPFP group and 71 in the non-LPFP group. The LPFP technique was associated with a shorter time to urinary continence recovery, a shorter operative time and lower estimated blood loss. Surgical and oncological outcomes, including complications, pathological T-stage, surgical margin status, and biochemical recurrence-free survival, were comparable between the two groups. This study demonstrated that the LPFP technique improves urinary continence recovery and operative times without compromising surgical and oncological outcomes. The use of this technique in patients with clinically localized prostate cancer is recommended.

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  • NR5A2/HSD3B1 pathway promotes cellular resistance to second-generation antiandrogen darolutamide. International journal

    Masaki Shiota, Miho Ushijima, Shigehiro Tsukahara, Shohei Nagakawa, Leandro Blas, Dai Takamatsu, Satoshi Kobayashi, Takashi Matsumoto, Junichi Inokuchi, Masatoshi Eto

    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy   70   100990 - 100990   2023.7   ISSN:1368-7646 eISSN:1532-2084

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    This study investigated cellular mechanisms in steroidogenesis responsible for treatment resistance to the novel antiandrogen agent darolutamide in prostate cancer. HSD3B1 was overexpressed in darolutamide-resistant cells and induced by darolutamide treatment and AR knockdown. Inversely, HSD3B1 knockdown increased cellular sensitivity to darolutamide. Similarly, its upstream regulator NR5A2 was up-regulated in darolutamide-resistant cells and induced by darolutamide treatment and AR knockdown. Inversely, NR5A2 knockdown and NR5A2 inhibitor ML180 decreased expression of various steroidogenic enzymes including HSD3B1, leading to increased cellular sensitivity to darolutamide. The NR5A2/HSD3B1 pathway promoted cellular resistance to darolutamide and targeting NR5A2/HSD3B1 pathway is a promising therapeutic strategy to overcome darolutamide resistance.

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  • Feasibility of multi-section continuum robotic ureteroscope in the kidney. Reviewed International journal

    Satoshi Kobayashi, Fumitaro Masaki, Franklin King, Daniel A Wollin, Adam S Kibel, Nobuhiko Hata

    Journal of robotic surgery   17 ( 4 )   1411 - 1420   2023.1   ISSN:1863-2483 eISSN:1863-2491

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    Our objective was to evaluate the feasibility of a multi-section continuum robotic ureteroscope to address the difficulties with access into certain renal calyces during flexible ureteroscopy. First, the robotic ureteroscope developed in previous research, which utilizes three actuated bendable sections controlled by wires, was modified for use in this project. Second, using phantom models created from five randomly selected computer tomography urograms, the flexible ureteroscope and robotic ureteroscope were evaluated, focusing on several factors: time taken to access each renal calyx, time taken to aim at three targets on each renal calyx, the force generated in the renal pelvic wall associated with ureteroscope manipulation, and the distance and standard deviation between the ureteroscope and the target. As a result, the robotic ureteroscope utilized significantly less force during lower pole calyx access (flexible ureteroscope vs. robotic ureteroscope; 2.0 vs. 0.98 N, p = 0.03). When aiming at targets, the standard deviation of proper target access was smaller for each renal calyx (upper pole: 0.49 vs. 0.11 mm, middle: 0.84 vs. 0.12 mm, lower pole: 3.4 vs. 0.19 mm) in the robotic ureteroscope group, and the distance between the center point of the ureteroscope image and the target was significantly smaller in the robotic ureteroscope group (upper: 0.49 vs. 0.19 mm, p < 0.001, middle: 0.77 vs. 0.17 mm, p < 0.001, lower: 0.77 vs. 0.22 mm, p < 0.001). In conclusion, our robotic ureteroscope demonstrated improved maneuverability and facilitated accuracy and precision while reducing the force on the renal pelvic wall during access into each renal calyx.

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  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention. Reviewed International journal

    Satoshi Kobayashi, Franklin King, Nobuhiko Hata

    International journal of computer assisted radiology and surgery   18 ( 3 )   449 - 460   2022.9   ISSN:1861-6410 eISSN:1861-6429

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    PURPOSE: Understanding the three-dimensional anatomy of percutaneous intervention in prostate cancer is essential to avoid complications. Recently, attempts have been made to use machine learning to automate the segmentation of functional structures such as the prostate gland, rectum, and bladder. However, a paucity of material is available to segment extracapsular structures that are known to cause needle deflection during percutaneous interventions. This research aims to explore the feasibility of the automatic segmentation of prostate and extracapsular structures to predict needle deflection. METHODS: Using pelvic magnetic resonance imagings (MRIs), 3D U-Net was trained and optimized for the prostate and extracapsular structures (bladder, rectum, pubic bone, pelvic diaphragm muscle, bulbospongiosus muscle, bull of the penis, ischiocavernosus muscle, crus of the penis, transverse perineal muscle, obturator internus muscle, and seminal vesicle). The segmentation accuracy was validated by putting intra-procedural MRIs into the 3D U-Net to segment the prostate and extracapsular structures in the image. Then, the segmented structures were used to predict deflected needle path in in-bore MRI-guided biopsy using a model-based approach. RESULTS: The 3D U-Net yielded Dice scores to parenchymal organs (0.61-0.83), such as prostate, bladder, rectum, bulb of the penis, crus of the penis, but lower in muscle structures (0.03-0.31), except and obturator internus muscle (0.71). The 3D U-Net showed higher Dice scores for functional structures ([Formula: see text]0.001) and complication-related structures ([Formula: see text]0.001). The segmentation of extracapsular anatomies helped to predict the deflected needle path in MRI-guided prostate interventions of the prostate with the accuracy of 0.9 to 4.9 mm. CONCLUSION: Our segmentation method using 3D U-Net provided an accurate anatomical understanding of the prostate and extracapsular structures. In addition, our method was suitable for segmenting functional and complication-related structures. Finally, 3D images of the prostate and extracapsular structures could simulate the needle pathway to predict needle deflections.

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  • Artificial Intelligence for Segmentation of Bladder Tumor Cystoscopic Images Performed by U-Net with Dilated Convolution. Reviewed International journal

    Jun Mutaguchi, Ken'ichi Morooka, Satoshi Kobayashi, Aiko Umehara, Shoko Miyauchi, Fumio Kinoshita, Junichi Inokuchi, Yoshinao Oda, Ryo Kurazume, Masatoshi Eto

    Journal of endourology   36 ( 6 )   827 - 834   2022.6   ISSN:0892-7790 eISSN:1557-900X

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    BACKGROUND: Early intravesical recurrence after transurethral resection of bladder tumors (TURBT) is often caused by overlooking of tumors during TURBT. Although narrow-band imaging and photodynamic diagnosis were developed to detect more tumors than conventional white-light imaging, the accuracy of these systems has been subjective, along with poor reproducibility due to their dependence on the physician's experience and skills. To create an objective and reproducible diagnosing system, we aimed to assess the utility of artificial intelligence (AI) with Dilated U-Net to reduce the risk of overlooked bladder tumors when compared with the conventional AI system, termed U-Net. MATERIAL AND METHODS: We retrospectively obtained cystoscopic images by converting videos obtained from 120 patients who underwent TURBT into 1,790 cystoscopic images. The Dilated U-Net, which is an extension of the conventional U-Net, analyzed these image datasets. The diagnostic accuracy of the Dilated U-Net and conventional U-Net were compared using the following four measurements: pixel-wise sensitivity (PWSe); pixel-wise specificity (PWSp); pixel-wise positive predictive value (PWPPV), representing the AI diagnostic accuracy per pixel; and dice similarity coefficient (DSC), representing the overlap area between the bladder tumors in the ground truth images and segmentation maps. RESULTS: The cystoscopic images were divided as follows, according to the pathological T-stage: 944, Ta; 412, T1; 329, T2; and 116, carcinoma in-situ. The PWSe, PWSp, PWPPV, and DSC of the Dilated U-Net were 84.9%, 88.5%, 86.7%, and 83.0%, respectively, which had improved when compared to that with the conventional U-Net by 1.7%, 1.3%, 2.1%, and 2.3%, respectively. The DSC values were high for elevated lesions and low for flat lesions for both Dilated and conventional U-Net. CONCLUSIONS: Dilated U-Net, with higher DSC values than conventional U-Net, might reduce the risk of overlooking bladder tumors during cystoscopy and TURBT.

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  • Artificial Intelligence for Segmentation of Bladder Tumor Cystoscopic Images Performed by U-Net with Dilated Convolution Invited Reviewed International journal

    @Mutaguchi J, @Morooka K, @Kobayashi S, @Umehara A, @Miyauchi S, @Kinoshita F, @Inokuchi J, @Oda Y, @Kurazume R, @Eto M.

    J Endourol. 2022 Jun;36(6):827-834. doi: 10.1089/end.2021.0483. Epub 2022 May 17.   2022.6

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  • 医工連携で課題解決 RAPNにおける超音波プローブアタッチメント開発

    小林 聡, 中楯 龍, 宮田 信一, 牟田口 淳, 李 賢, 門司 恵介, 柏木 英志, 武内 在雄, 塩田 真己, 猪口 淳一, 江藤 正俊

    Japanese Journal of Endourology and Robotics   35 ( 1 )   109 - 118   2022.4

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    ロボット支援腎部分切除術の術中超音波検査は,腎腫瘍を確実に切除するために必須である.術中超音波検査に用いられるL43Kプローブは,この術式に使用される超音波プローブの1つであり,術中はフェネストレイテッド鉗子でプローブのフィンを把持して使用する.RAPNは狭い後腹膜腔で鉗子を使ってプローブを操作しなければならず,プローブ先端からフィンを把持することが頻回にあった.このフィンはプローブ先端に向かって傾斜が低くなりかつ放射状に広がっている構造のため,プローブ先端から把持できない設計になっている.これが原因でプローブ先端からの把持は安定せず,プローブを頻回に落としていた.今回我々はプローブの先端から把持しづらい課題に対して,医工連携を通してプローブアタッチメントを開発して解決したので報告する.(著者抄録)

  • Predictive factors of survival outcomes in first-line therapy for metastatic castration-resistant prostate cancer. Reviewed International journal

    Masaki Shiota, Leandro Blas, Satoshi Kobayashi, Takashi Matsumoto, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Ken-Ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    International journal of urology : official journal of the Japanese Urological Association   29 ( 1 )   26 - 32   2022.1   ISSN:0919-8172 eISSN:1442-2042

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    OBJECTIVES: To investigate predictive factors of survival of metastatic castration-resistant prostate cancer patients undergoing first-line treatment with androgen receptor pathway inhibitors or docetaxel. METHODS: Japanese patients with metastatic castration-resistant prostate cancer treated with androgen receptor pathway inhibitor or docetaxel between 2008 and 2018 were included. The differential impact of various clinicopathological factors on the outcome, including progression-free survival and overall survival, was compared between treatment with androgen receptor pathway inhibitor and docetaxel. RESULTS: Of 254 patients with metastatic castration-resistant prostate cancer, 119 (46.9%) and 135 (53.2%) were treated with androgen receptor pathway inhibitor and docetaxel, respectively. The multivariate analysis showed that androgen receptor pathway inhibitor was an independent prognostic factor for better progression-free survival (hazard ratio 0.62, 95% confidence interval 0.42-0.92, P = 0.016) and overall survival (hazard ratio 0.61, 95% confidence interval 0.41-0.93, P = 0.021), compared with docetaxel. Pretreatment prostate-specific antigen levels and time to castration-resistant prostate cancer were differentially associated with progression-free survival and overall survival between androgen receptor pathway inhibitor or docetaxel. In patients who presented <6 months to castration-resistant prostate cancer, progression-free survival was shorter in those treated with androgen receptor pathway inhibitor (median 1.1 months, 95% confidence interval 0.2-2.8 months) compared with those who received docetaxel (median 5.0 months, 95% confidence interval 1.8-6.7 months; P = 0.014). CONCLUSIONS: First-line therapy with androgen receptor pathway inhibitor is associated with a better prognosis when compared with docetaxel, even after adjustment for prognostic factors. However, a shorter time to castration-resistant prostate cancer is associated with better progression-free survival for patients receiving docetaxel, suggesting that docetaxel is the preferred option for patients with a shorter time to castration-resistant prostate cancer.

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  • Differential prognostic impact of complete blood count-related parameters by prior use of novel androgen receptor pathway inhibitors in docetaxel-treated castration-resistant prostate cancer patients. Reviewed International journal

    Hiroki Kobayashi, Masaki Shiota, Nobuaki Sato, Satoshi Kobayashi, Takashi Matsumoto, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Ken-Ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    Anti-cancer drugs   33 ( 1 )   e541-e547 - E547   2022.1   ISSN:0959-4973 eISSN:1473-5741

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    There are multiple reports on the value of complete blood count (CBC)-related parameters on prognosis in docetaxel-treated castration-resistant prostate cancer (CRPC) patients before the emergence of androgen receptor pathway inhibitors (ARPIs). We investigated the prognostic significance of CBC-related parameters in docetaxel-treated CRPC patients. Patients treated with docetaxel chemotherapy for CRPC between 2008 and 2018 were included. We analyzed the relevance of CBC-related parameters to oncological prognosis in docetaxel chemotherapy, associated with prior use of novel ARPIs. Among 144 Japanese men treated with docetaxel, 49 men (34.0%) had already received ARPI therapy. A high neutrophil-lymphocyte ratio (NLR) was a prognostic factor for poor progression-free survival and overall survival (OS) in both univariate and multivariate analyses. In addition, a low hemoglobin (Hb) level and a high systemic immune-inflammation index (SII) were prognostic factors of poor OS in univariate analysis. Hb level was a prognostic factor of OS in both ARPI-naive and ARPI-treated patients. However, a high NLR and SII were only associated with a poor prognosis in ARPI-naive but not in ARPI-treated patients. Hb, NLR, and SII have been suggested to be prognosticators in docetaxel-treated CRPC patients. The differential prognostic value of NLR and SII between ARPI-naive and ARPI-treated patients may require caution when using these markers in docetaxel-treated CRPC patients.

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  • Differential prognostic impact of complete blood count-related parameters by prior use of novel androgen receptor pathway inhibitors in docetaxel-treated castration-resistant prostate cancer patients Invited Reviewed International journal

    @Kobayashi H, @Shiota M, @Sato N, @Kobayashi S, @Matsumoto T, @Monji K, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Anticancer Drugs. 2022 Jan 1;33(1):e541-e547. doi: 10.1097/CAD.0000000000001170.   2022.1

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  • Predictive factors of survival outcomes in first-line therapy for metastatic castration-resistant prostate cancer Invited Reviewed International journal

    @Shiota M, @Blas L, @Kobayashi S, @Matsumoto T, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Int J Urol. 2022 Jan;29(1):26-32. doi: 10.1111/iju.14702. Epub 2021 Sep 22.   2022.1

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  • 転移性去勢抵抗性前立腺癌に対する一次治療の生存成績に関する予測因子(Predictive factors of survival outcomes in first-line therapy for metastatic castration-resistant prostate cancer)

    Shiota Masaki, Blas Leandro, Kobayashi Satoshi, Matsumoto Takashi, Kashiwagi Eiji, Takeuchi Ario, Inokuchi Junichi, Shiga Ken-ichiro, Yokomizo Akira, Eto Masatoshi

    International Journal of Urology   29 ( 1 )   26 - 32   2022.1   ISSN:0919-8172

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    転移性去勢抵抗性前立腺癌(CRPC)の第一選択治療としてアンドロゲン受容体経路阻害剤(ARPI)やドセタキセルの臨床転帰に関する予測マーカーを検討した。2008年から2018年までにARPIまたはドセタキセルによる治療を受けた転移性CRPCの日本人患者254例(年齢中央値73歳)を対象とした。転移性CRPC患者254例のうち、119例と135例がそれぞれARPIとドセタキセルを受けた。多変量解析の結果、ARPIは、ドセタキセルと比較して、無増悪生存期間(PFS)(ハザード比0.62、95%CI 0.42~0.92、p=0.016)および全生存期間(OS)(ハザード比0.61、95%CI 0.41~0.93、p=0.021のより良い独立した予後因子であった。治療前の前立腺特異抗原レベルとCRPCになるまでの期間は、ARPIとドセタキセルでは、PFSやOSと異なる相関が認められた。CRPCを6ヵ月未満で発症した患者のうち、ARPIを受けた患者のPFS(中央値1.1ヵ月、95%CI 0.2~2.8ヵ月)は、ドセタキセルを受けた患者のPFS(中央値5.0ヵ月、95%CI 1.8~6.7ヵ月、p=0.014)よりも短かった。以上より、ARPIによる一次治療は、予後因子を調整した後でも、ドセタキセルと比較してより良い予後と関連していた。

  • Development of ultrasound probe attachment for robot-assisted partial nephrectomy through medical- engineering collaboration

    Satoshi Kobayashi

    Japanese Journal of Endourology and Robotics   2022

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  • Development of ultrasound probe attachment for robot-assisted partial nephrectomy through medical-engineering collaboration

    小林 聡, 中楯 龍, 宮田 信一, 牟田口 淳, 李 賢, 門司 恵介, 柏木 英志, 武内 在雄, 塩田 真己, 猪口 淳一, 江藤 正俊

    Japanese Journal of Endourology and Robotics   35 ( 1 )   109 - 118   2022   eISSN:2436875X

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    <p>  Intraoperative laparoscopic ultrasound in robot-assisted partial nephrectomy is essential to reliably remove a renal tumor. The L43K probe used for intraoperative laparoscopic ultrasound is one of the ultrasound probes used in this surgery, and the fins of the probe are grasped with fenestrated forceps during surgery. Surgeons must manipulate the robot in a narrow retroperitoneal cavity and often grip the fins from the probe’s tip. The conventional probe fin toward the probe tip has a structure in which the inclination becomes low grasp is not spread radially, and is designed not to be gripped from the probe tip. Therefore, the unstable while gripping the probe’s tip, and surgeons have frequently dropped the probe. In this study, we propose a solution to resolve this gripping difficulty by developing a probe attachment.</p>

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  • ナビゲーションシステムを用いたRAPNの実践

    小林 聡, 月野 圭治, 李 賢, 門司 恵介, 柏木 英志, 塩田 真己, 猪口 淳一, 江藤 正俊

    Japanese Journal of Endourology and Robotics   35 ( 2 )   198 - 202   2022   eISSN:2436875X

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    <p> 腎腫瘍は局在と形態は多岐にわたり, 腎血管の数と形態にも個体差がある. 従って, ロボット支援腎部分切除術 (robot-assisted partial nephrectomy ; RAPN) では多様な解剖学的特徴を踏まえ手術のアプローチ方法を術前に計画しておく必要がある. この術前計画において, 医療画像から作成された腎癌3D画像は, 腎腫瘍や腎血管の情報を視覚的に理解するのに役立ち, この画像を使った3次元的な解剖理解によって腎動脈の遮断予定部位, 温存可能な血管の確認と腫瘍切除に伴う尿路の損傷範囲を予測することが可能となり, 詳細な術前計画を立てることができる. しかし, 3D画像を生成するためには, 医用画像解析ワークステーションとソフトウエアが必要となり, これらを扱うための専門知識がユーザーには求められる. また, 多様なソフトウエアをクラウドベースまたはサブスクライブされたアプリケーションの中から, ユーザーの用途に合わせて選択しなければならない. そして, ユーザーはソフトウエアを使って腎臓, 腫瘍, 腎血管や尿路をセグメンテーションしてラベルデータを作成し, このデータをレンダリングして3D画像を作成することになる. 従って, ソフトウエアを使った腎癌3D画像の作成は, RAPNのナビゲーションを実施する上で重要でかつ最初のタスクである. しかし, このタスクを遂行する上で, 多くの医療者は医療解析ソフトの特性からその操作方法に至るまでの知識と経験を持ち合わせていない場合があり, 3D画像を使ったRAPNのナビゲーションの導入についてハードルが高く感じていることがある.</p><p> 本稿では, ナビゲーションを実践するために重要な腎癌3D画像の作成について, 最新の知見を含め報告する.</p>

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  • Practice with Navigation Systems in RAPN.

    Satoshi Kobayashi

    Japanese Journal of Endourology and Robotics   2022

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    2022, 35:1-5.

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  • Editorial Comment to Endoscopic laser treatment for urine leakage caused by an isolated calyx after robot-assisted partial nephrectomy. Reviewed International journal

    Satoshi Kobayashi, Masaki Shiota

    IJU case reports   4 ( 6 )   346 - 346   2021.11

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    DOI: 10.1002/iju5.12349

  • SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study Reviewed

    Dmitri Nepogodiev, Joana F.F. Simoes, Elizabeth Li, James Glasbey, Maria Picciochi, Sivesh K. Kamarajah, Rohan Gujjuri, Aneel Bhangu, A. Maryam, Mohammed A. Azab, Mohammed A. Zahran, Areej A. Abdelaziz, Junaid Aamir, Norhafiza Ab Rahman, Muna Aba Zaid, Muath Abaalkhail, Adnan Ababneh, Hazim Ababneh, Laila Ababneh, Roba Ababneh, Rafael Abad Alonso, Alfredo Abad Gurumeta, Ane Abad-Motos, Mussab Abaker, Ryan Rainiel Abary, Adam Abass, Emmanuele Abate, Sheraz Abayazeed Ahmed, Olukayode Abayomi, Alaa Abazeed, Bader Abbad, Francesco Abbadessa, Osaid Abbadi, Malaz Abbakar, Ahmed M. Abbas, Alzhraa Salah Abbas, Asad Abbas, Aya M. Abbas, Jihad Abbas, Manzar Abbas, Mohammad Monir Abbas, Omer Abbas, Aykhan Abbasov, Olivier Abbo, Daniel Abbott, Tom Abbott, Omar Sudig Abboud, Waleed Abd, Tayma Abd Alghafour, Wael Abd El-Ghani, Mustafa Abd Elsayed, Ahmed Abd Elwahab, Sami Abd Elwahab, Ahmed Yassien Abd-Elkariem, Sherief Abd-Elsalam, Joel Abdala Junior, Ahmad Abdalah, Alya Abdalhadi, Ahmed Abdalla, Eman Adam Abdalla, Samir Abdalla, Shimaa Abdalla, Siddig Abdalla, Emne Abdallah, Ghaida Abdallah, Lubna Abdallah, Munir Abdallah, Rasha Abdallah, Hani Abdalnour, Bashar Abdeen, Saedah Abdeewi, Louai Abdeh, Shrouk Abdel Fattah, Mahmoud Abdel-Aleem, Wafaa Abdel-Elsalam, Areej Abdel-Fattah, Nour Abdel-Fattah, Ibrahim Abdel-Hafez, Abdelrahman Abdelaal, Khaled Abdelazeem, Mohammed Abdelaziz, Mohamad Abdelbagi, Abouelnour Abdelbaset, Hesham Abdeldayem, Mahmoud Abdelfattah, Alwaleed Abdelgadir, Khaled Abdelgalel, Moslem Abdelghafar, Mohammed Abdelhafez, Abdelkarim Abdeljalil, Mohammed Abdelkabir, Ibrahim Abdelkader Salama, Mohamed Abdelkareem, Mohamed M. Abdelkarem, Mostafa Abdelkarim, Mohamed Abdelkhalek, Fatima Abdellah, Ahmed Abdelmajeed, Abubaker Abdelmalik, Ahmed Abdelmawla

    British Journal of Surgery   108 ( 9 )   1056 - 1063   2021.9

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    <jats:title>Abstract</jats:title>
    <jats:sec>
    <jats:title>Background</jats:title>
    <jats:p>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Methods</jats:title>
    <jats:p>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Results</jats:title>
    <jats:p>NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Conclusion</jats:title>
    <jats:p>As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.</jats:p>
    </jats:sec>

    DOI: 10.1093/bjs/znab101

  • Prognostic impact of prior local therapy in castration-resistant prostate cancer Invited Reviewed International journal

    @Koura M, @Shiota M, @Ueda S, @Matsumoto T, @Kobayashi S, @Monji K, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Jpn J Clin Oncol. 2021 Jul 1;51(7):1142-1148. doi: 10.1093/jjco/hyab019.   2021.7

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  • Prognostic impact of prior local therapy in castration-resistant prostate cancer Reviewed International journal

    Mikifumi Koura, Masaki Shiota, Shohei Ueda, Takashi Matsumoto, Satoshi Kobayashi, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Ken-ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    Japanese Journal of Clinical Oncology   51 ( 7 )   1142 - 1148   2021.7

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    <jats:title>Abstract</jats:title>
    <jats:sec>
    <jats:title>Objective</jats:title>
    <jats:p>This study aimed to reveal the prognostic values of prior local therapy in first-line therapy using androgen receptor-axis targeting agents (abiraterone or enzalutamide) or docetaxel for castration-resistant prostate cancer (CRPC).</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Methods</jats:title>
    <jats:p>The study included 303 patients treated with first-line therapy for non-metastatic and metastatic CRPC. The association between prior local therapy and therapeutic outcome including progression-free survival and overall survival was investigated by univariate and multivariate analyses as well as propensity score-matched analysis.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Results</jats:title>
    <jats:p>In univariate analysis, local prior therapy was associated with a lower risk of all-cause mortality (hazard ratio, 0.56, 95% confidence interval, 0.40–0.79; P = 0.0009). Overall survival, but not progression-free survival, was better among patients with prior local therapy compared with patients without prior local therapy even after multivariate analysis and propensity score-matched analysis.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Conclusions</jats:title>
    <jats:p>This study robustly indicated that prior local treatment was prognostic for overall survival among patients with CRPC. This finding is useful to predict patient prognosis in CRPC.</jats:p>
    </jats:sec>

    DOI: 10.1093/jjco/hyab019

  • Prognostic significance of complete blood count parameters in castration-resistant prostate cancer patients treated with androgen receptor pathway inhibitors. Reviewed International journal

    Asako Machidori, Masaki Shiota, Satoshi Kobayashi, Takashi Matsumoto, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Masatoshi Eto

    Urologic oncology   39 ( 6 )   365.e1-365.e7 - 365.e7   2021.6

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    BACKGROUND: This study investigated the prognostic significance of complete blood count data in castration-resistant prostate cancer patients treated using androgen receptor pathway inhibitors (ARPIs). PATIENTS AND METHODS: Patients treated with an ARPI, abiraterone or enzalutamide, as first-line therapy for castration-resistant prostate cancer from 2014 to 2018 were included. The association between complete blood count data and prognoses including progression-free survival and overall survival (OS) was investigated. RESULTS: High white blood cell counts (<median vs. ≥median; hazard ratio [HR], 1.82, 95% confidence interval [CI], 1.14-2.89; P = 0.012) and high neutrophil-to-lymphocyte ratios (<median vs. ≥median; HR, 1.90, 95% CI, 1.11-3.27; P = 0.020) were associated with a high risk of progression in univariate analysis. In univariate analysis, high hemoglobin (Hb) levels (<median vs. ≥median; HR, 0.41, 95% CI, 0.24-0.73; P = 0.0023) and high red cell distribution widths (<median vs. ≥median; HR, 2.41, 95% CI, 1.37-4.25; P = 0.0023) were associated with a low and a high risk of all-cause mortality, respectively. In multivariate analysis, high Hb levels (<median vs. ≥median; HR, 0.42, 95% CI, 0.22-0.79; P = 0.0076) were repeatedly associated with a low risk of all-cause mortality. CONCLUSION: We found that white blood cell counts and neutrophil-to-lymphocyte ratios may be prognostic for progression-free survival while red cell distribution widths may be prognostic for OS. In particular, a low Hb level was a robust prognostic factor for poor OS. These findings could be useful in predicting prognosis in CRPC patients treated with ARPIs.

    DOI: 10.1016/j.urolonc.2020.09.036

  • Clinical advantages of robot‐assisted partial nephrectomy versus laparoscopic partial nephrectomy in terms of global and split renal functions: A propensity score‐matched comparative analysis Reviewed International journal

    Satoshi Kobayashi, Jun Mutaguchi, Eiji Kashiwagi, Ario Takeuchi, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto

    International Journal of Urology   28 ( 6 )   630 - 636   2021.6

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    OBJECTIVES: To identify predictors of renal function preservation, and to compare the global and split renal function outcomes of robot-assisted partial nephrectomy and laparoscopic partial nephrectomy. METHODS: Demographic, operative and pathological data, as well as renal function outcomes, of 251 patients who underwent laparoscopic (n = 104) and robot-assisted (n = 147) partial nephrectomy between 2008 and 2018 were retrospectively analyzed. Propensity score matching (1:1) was carried out to adjust for potential baseline confounders. Functional outcomes were assessed based on the estimated glomerular filtration rate and dynamic renal scintigraphy (using 99m Tc-mercaptoacetyltriglycine), including renal volumetric analysis. RESULTS: A total of 98 patients were allocated to each partial nephrectomy group. Ischemic (laparoscopic vs robot-assisted partial nephrectomy: 29 vs 15 min, P < 0.001) and operative times (181 vs 100 min, P < 0.001) were shorter in robot-assisted partial nephrectomy. The preservation ratio of global renal function at 3 months (88.3% vs 91.4%, P = 0.040) and 12 months (87.8% vs 91.5%, P = 0.010) postoperatively, and the renal function of the operated kidney (80.3% vs 88.2%, P < 0.001) were greater after robot-assisted partial nephrectomy. In robot-assisted partial nephrectomy, the volume of resected parenchyma was significantly smaller (27.2 vs 15.5 mL, P < 0.001), resulting in greater postoperative normal parenchymal volumes (120 vs 132 mL, P < 0.001) and a greater parenchymal preservation ratio (81.1% vs 90.1%, P < 0.001). The parenchymal preservation ratio was the strongest predictor of renal function preservation after surgery (P < 0.001, odds ratio 6.02). CONCLUSIONS: Robot-assisted partial nephrectomy allows better preservation of split renal function than laparoscopic partial nephrectomy by increasing the parenchymal preservation ratio. This translates into better postoperative global renal function.

    DOI: 10.1111/iju.14525

  • Clinical advantages of robot-assisted partial nephrectomy versus laparoscopic partial nephrectomy in terms of global and split renal functions: A propensity score-matched comparative analysis Invited Reviewed International journal

    @Kobayashi S, @Mutaguchi J, @Kashiwagi E, @Takeuchi A, @Shiota M, @Inokuchi J, @Eto M.

    Int J Urol. 2021 Jun;28(6):630-636. doi: 10.1111/iju.14525. Epub 2021 Mar 3.   2021.6

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  • Prognostic significance of complete blood count parameters in castration-resistant prostate cancer patients treated with androgen receptor pathway inhibitors Invited Reviewed International journal

    @Machidori A, @Shiota M, @Kobayashi S, @Matsumoto T, @Monji K, @Kashiwagi E, @Takeuchi A, @Takahashi R, @Inokuchi J, @Eto M.

    Urol Oncol. 2021 Jun;39(6):365.e1-365.e7. doi: 10.1016/j.urolonc.2020.09.036. Epub 2020 Oct 17.   2021.6

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  • Urinary collecting system invasion on multiphasic CT in renal cell carcinomas: prevalence, characteristics, and clinical significance. Reviewed International journal

    Atsushi Takamatsu, Kotaro Yoshida, Masaru Obokata, Dai Inoue, Norihide Yoneda, Yoshifumi Kadono, Satoshi Kobayashi, Toshifumi Gabata

    Abdominal radiology (New York)   46 ( 5 )   2090 - 2096   2021.5

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    PURPOSE: The aim of this study was to determine the prevalence of collecting system invasion (CSI) on multiphasic CT, validate the pathological findings, and investigate the relationship between CSI and clinical outcomes in patients with renal cell carcinomas (RCC). METHODS: Patients pathologically diagnosed with RCC between January 2008 and December 2017 were retrospectively enrolled in this study. They were divided into two groups according to the presence of CSI on multiphasic CT images. Patients' clinical characteristics, radiological findings, and overall survival (OS) and recurrence-free survival (RFS) rates were analyzed and compared between the groups. In addition, the correlation of radiological findings with pathological findings was investigated. RESULTS: Among the included 347 kidneys of 340 patients, CSI was observed in 11 kidneys (3%; 95% confidence interval, 1.3-5.0%). In all the 11 kidneys, the tumors were pathologically diagnosed as clear cell RCC, and in one kidney, the tumor also had sarcomatoid features. When pathological CSI served as the standard of reference, the sensitivity, specificity, and accuracy of CSI on CT were 50%, 99.7%, and 97.1%, respectively. The OS and RFS rates were not significantly different between patients with CSI on CT and those without CSI. CONCLUSION: This study found that the prevalence of RCC-related CSI was 3%. Because of the low prevalence, we cannot exclude the possibility that CSI on CT would be associated with the OS and RFS. Further studies are needed to determine whether CSI on CT can be an independent prognostic factor for survival in patients with RCC.

    DOI: 10.1007/s00261-020-02859-y

  • Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy: a case report. Reviewed International journal

    Hiroki Kobayashi, Satoshi Kobayashi, Masaki Shiota, Dai Takamatsu, Tatsuro Abe, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Kenichi Kohashi, Yoshiyuki Shioyama, Yoshinao Oda, Masatoshi Eto

    International cancer conference journal   10 ( 2 )   96 - 99   2021.4

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    Salvage radical prostatectomy is a therapeutic option for the biochemical recurrence of prostate cancer after radiotherapy. However, only one case report of salvage radical prostatectomy after carbon ion radiotherapy has been reported. We report a case of salvage robot-assisted radical prostatectomy for local recurrence of prostate cancer after carbon ion radiotherapy with surgical video. Owing to adhesion and degeneration after radiotherapy, difficulties in surgery and post-operative complications have been anticipated. However, surgery was feasible without severe peri- and post-operative complications. Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy may be a reasonable therapeutic option. Supplementary Information: The online version contains supplementary material available at 10.1007/s13691-020-00464-w.

    DOI: 10.1007/s13691-020-00464-w

  • Efficacy and Safety of 4-Weekly Docetaxel for Castration-Resistant Prostate Cancer Reviewed International journal

    Takuya Yamashita, Masaki Shiota, Asako Machidori, Satoshi Kobayashi, Takashi Matsumoto, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Ken-ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    Cancer Investigation   39 ( 3 )   251 - 256   2021.3

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    We investigated the efficacy and safety profiles of 4-weekly docetaxel for castration-resistant prostate cancer. Patients treated with ≥2 courses of docetaxel chemotherapy (median, 70 mg/m2) between 2008 and 2018 were included. Among 125 Japanese men, 40 (32.0%) and 85 (68.0%) were treated with 3-weekly and 4-weekly regimens, respectively. In the 4-weekly regimen, the risks of progression, treatment failure, and any-cause mortality were comparable to those in the 3-weekly regimen. The incidences of severe adverse events were also similar between the 3-weekly and 4-weekly regimens. These data suggest that the 4-weekly regimen may be an acceptable option for selected patients.

    DOI: 10.1080/07357907.2020.1871486

  • Efficacy and Safety of 4-Weekly Docetaxel for Castration-Resistant Prostate Cancer Invited Reviewed International journal

    @Yamashita T, @Shiota M, @Machidori A, @Kobayashi S, @Matsumoto T, @Monji K, @Kashiwagi E, @Takeuchi A, @Takahashi R, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Cancer Invest. 2021 Mar;39(3):251-256. doi: 10.1080/07357907.2020.1871486. Epub 2021 Jan 14.   2021.3

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  • Examination of the Prefrontal Cortex Hemodynamic Responses to the Fist-Edge-Palm Task in Naïve Subjects Using Functional Near-Infrared Spectroscopy Invited Reviewed International journal

    @Kobayashi S, @Iwama Y, @Nishimaru H, @Matsumoto J, @Setogawa T, @Ono T, @Nishijo H.

    Front Hum Neurosci. 2021 Feb 5;15:617626. doi: 10.3389/fnhum.2021.617626. eCollection 2021.   2021.2

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  • Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy: a case report Invited Reviewed International journal

    @Kobayashi H, @Kobayashi S, @Shiota M, @Takamatsu D, @Abe T, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Kohashi K, @Shioyama Y, @Oda Y, @Eto M.

    Int Cancer Conf J. 2021 Jan 3;10(2):96-99. doi: 10.1007/s13691-020-00464-w. eCollection 2021 Apr.   2021.1

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  • Surgical Navigation Improves Renal Parenchyma Volume Preservation in Robot-Assisted Partial Nephrectomy: A Propensity Score Matched Comparative Analysis Invited Reviewed International journal

    @Kobayashi S, @Cho B, @Mutaguchi J, @Inokuchi J, @Tatsugami K, @Hashizume M, @Eto M.

    J Urol. 2020 Jul;204(1):149-156. doi: 10.1097/JU.0000000000000709. Epub 2020 Dec 20.   2020.7

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  • Surgical Navigation Improves Renal Parenchyma Volume Preservation in Robot-Assisted Partial Nephrectomy: A Propensity Score Matched Comparative Analysis Reviewed International journal

    Satoshi Kobayashi, Byunghyun Cho, Jun Mutaguchi, Junichi Inokuchi, Katsunori Tatsugami, Makoto Hashizume, Masatoshi Eto

    Journal of Urology   204 ( 1 )   149 - 156   2020.7

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    PURPOSE: We investigated the relationship between the surgical navigation system and postoperative parenchyma preservation volume, and assessed the feasibility of image guided surgery in robot-assisted partial nephrectomy. MATERIALS AND METHODS: We developed surgical navigation with registration between real-time endoscopic images using 3-dimensional virtual reality models for robot-assisted partial nephrectomy. Surgical outcomes of 44 (nonsurgical navigation group) and 102 (surgical navigation group) patients between June 2013 and December 2018 were retrospectively analyzed. To adjust for potential baseline confounders propensity score matching (1:1) was performed. Renal parenchymal preservation rate and extraparenchymal volume with a tumor including functional and oncological outcomes ("trifecta" defined as warm ischemia time of less than 25 minutes, no complications and negative surgical margins; "pentafecta" defined as trifecta plus greater than 90% preservation of estimated glomerular filtration rate at 12 months postoperatively and chronic kidney disease up staging) were evaluated using volumetric analysis and compared. RESULTS: After matching, 42 patients were allocated to each group. No significant differences in baseline characteristics; complications; and intraoperative, trifecta and pentafecta outcomes were observed between the 2 groups. Pathological T stages were significantly different between the groups (T1a/T1b/T2a or more 25/10/7 in the nonsurgical navigation group vs 35/7/0 in the surgical navigation group, p=0.003). Extraparenchymal volumes and parenchyma volume preservation rates were significantly higher in the surgical navigation group (21.4 vs 17.2 ml, p=0.041 and 83.5% vs 90.0%, p=0.042, respectively). Surgical navigation was positively associated with improved parenchyma preservation volume (p=0.003). CONCLUSIONS: Surgical navigation preserves renal parenchyma in robot-assisted partial nephrectomy and may contribute to improvement in postoperative renal function.

    DOI: 10.1097/ju.0000000000000709

  • Reply by Authors. Reviewed International journal

    Satoshi Kobayashi, Byunghyun Cho, Jun Mutaguchi, Junichi Inokuchi, Katsunori Tatsugami, Makoto Hashizume, Masatoshi Eto

    The Journal of urology   204 ( 1 )   156 - 156   2020.7

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    DOI: 10.1097/JU.0000000000000709.02

  • Assessment of surgical skills by using surgical navigation in robot-assisted partial nephrectomy Reviewed International journal

    Satoshi Kobayashi, Byunghyun Cho, Arnaud Huaulm{'{e } }, Katsunori Tatsugami, Hiroshi Honda, Pierre Jannin, Makoto Hashizumea, Masatoshi Eto

    International Journal of Computer Assisted Radiology and Surgery   14 ( 8 )   1449 - 1459   2019.8

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    PURPOSE: To assess surgical skills in robot-assisted partial nephrectomy (RAPN) with and without surgical navigation (SN). METHODS: We employed an SN system that synchronizes the real-time endoscopic image with a virtual reality three-dimensional (3D) model for RAPN and evaluated the skills of two expert surgeons with regard to the identification and dissection of the renal artery (non-SN group, n = 21 [first surgeon n = 9, second surgeon n = 12]; SN group, n = 32 [first surgeon n = 11, second surgeon n = 21]). We converted all movements of the robotic forceps during RAPN into a dedicated vocabulary. Using RAPN videos, we classified all movements of the robotic forceps into direct action (defined as movements of the robotic forceps that directly affect tissues) and connected motion (defined as movements that link actions). In addition, we analyzed the frequency, duration, and occupancy rate of the connected motion. RESULTS: In the SN group, the R.E.N.A.L nephrometry score was lower (7 vs. 6, P = 0.019) and the time to identify and dissect the renal artery (16 vs. 9 min, P = 0.008) was significantly shorter. The connected motions of inefficient "insert," "pull," and "rotate" motions were significantly improved by SN. SN significantly improved the frequency, duration, and occupancy rate of connected motions of the right hand of the first surgeon and of both hands of the second surgeon. The improvements in connected motions were positively associated with SN for both surgeons. CONCLUSION: This is the first study to investigate SN for nephron-sparing surgery. SN with 3D models might help improve the connected motions of expert surgeons to ensure efficient RAPN.

    DOI: 10.1007/s11548-019-01980-8

  • [Significance of the antimicrobial drug used to prevent febrile infection following prostate needle biopsy]. Reviewed

    Satoshi Kobayashi, Tomoko Maki, Takeshi Kobayashi, Masumitsu Hamaguchi, Masahiro Yoshikawa, Naotaka Sakamoto, Atushi Iguchi

    Hinyokika kiyo. Acta urologica Japonica   60 ( 5 )   227 - 30   2014.5

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    The rate of incidence of febrile infection and the antimicrobial drug used at the time of prostate needle biopsy was examined retrospectively. SPFX (sparfloxacin) 400 mg (January 2007 to March 2010) and LVFX (levofloxacin) 500 mg (April 2010, onward) were administered prophylactically in 1,034 patients undergoing transrectal or transperineal prostate biopsy. One febrile infection occurred and resolved in each group. A single dose of LVFX 500 mg before the procedure effectively prevented febrile infection in both transrectal and transperineal prostate needle biopsy.

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Books

  • 手術ナビゲーションの進歩

    月野圭治, 小林聡, 牟田口淳, 猪口淳一, 江藤正俊(Role:Joint author)

    日本臨床  2024.2 

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    Advances in surgical navigation

  • Advances in surgical navigation

    Keiji Tsukino, Satoshi Kobayashi, Jun Mutaguchi, Junichi Inoguchi, Masatoshi Eto(Role:Joint author)

    日本臨床  2024.2 

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  • 変わる医療-先端技術がもたらす新しい医療 手術ナビゲーションシステムがもたらす新しいロボット手術

    小林聡, 江藤正俊(Role:Sole author)

    映像情報Medical  2022.4 

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    Changing Medicine - New Medical Care Brought to You by Advanced Technology New Robotic Surgery Brought to You by Surgical Navigation Systems

  • Changing Medicine - New Medical Care Brought to You by Advanced Technology New Robotic Surgery Brought to You by Surgical Navigation Systems

    Satoshi Kobayashi, Masatoshi Eto(Role:Sole author)

    Video Information Medical  2022.4 

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  • 内視鏡手術におけるVR・ARの有用性

    小林 聡(Role:Sole author)

    臨床泌尿器  2021.9 

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    Usefulness of VR / AR in endoscopic surgery

  • 画像ナビゲーション手術の進歩

    小林 聡(Role:Sole author)

    日本臨床  2021.5 

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    Advances in image navigation surgery

  • 医療に活かす生体医工学

    小林 聡(Role:Joint author)

    2020.11 

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    Biomedical engineering for medical use

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Presentations

  • Feasibility of Multi-Section Continuum Robotic Ureteroscope in the Kidney

    Satoshi Kobayashi, Franklin King, Masaki Fumitaro, Daniel A Wollin, Adam Stuar, Kibel Nobuhiko Hata, Masatoshi Eto

    Société Internationale d'Urologie  2023.10 

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    Feasibility of Multi-Section Continuum Robotic Ureteroscope in the Kidney

  • Feasibility of Multi-Section Continuum Robotic Ureteroscope in the Kidney

    Satoshi Kobayashi, Franklin King, Masaki Fumitaro, Daniel A Wollin, Adam Stuar, Kibel Nobuhiko Hata, Masatoshi Eto

    Société Internationale d'Urologie  2023.10 

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    Event date: 2023.10

    Language:English   Presentation type:Oral presentation (general)  

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  • L43K超音波プローブアタッチメント開発における市販後調査

    小林聡, 中楯龍, 宮田信一, 月野圭治, 牟田口淳, 後藤駿介, 門司恵介, 塩田真己, 猪口淳一, 江藤正俊

    第32回日本コンピュータ外科学会大会  2023.12 

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    Post-marketing survey in the development of L43K ultrasound probe attachment

  • L43K超音波プローブ専用 アタッチメント. 医工連携特別企画:成功事例から学ぶ医工連携~JSER医工連携アワードプレゼン~ Invited

    小林聡

    第37回日本泌尿器内視鏡ロボティクス学会総会  2023.11 

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    Attachment for L43K ultrasound probe. Special project for medical-engineering collaboration: Learning about medical-engineering collaboration from successful cases ~ JSER Medical-Engineering Collaboration Award Presentation ~

  • RAPNナビゲーションにおける自動追尾用アタッチメントの開発

    月野圭治, 小林聡, 牟田口 淳, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 沖 英次, 江藤 正俊

    第37回日本泌尿器内視鏡ロボティクス学会総会  2023.11 

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    Development of automatic tracking attachment for RAPN navigation

  • ロボット支援手術内視鏡画像から 3D 臓器モデル画像を出力する画像変換モデルの構築

    月野圭治, 宮内翔子, 小林 聡, 小栗 晋, 牟田口 淳, 塚原茂大, 後藤駿介, 松元 崇, 門司恵介, 塩田真己, 猪口淳一, 沖 英次, 倉爪 亮, 江藤正俊

    第32回日本コンピュータ外科学会大会  2023.12 

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    Construction of an image conversion model that outputs 3D organ model images from robot-assisted surgery endoscopic images

  • 尿管鏡支援ロボットの実現可能性に向けた開発研究

    小林聡, 正木文太郎, Franklin King, Daniel A Wollin, Adam Stuart Kibel, 波多信彦, 江藤正俊

    第37回日本泌尿器内視鏡ロボティクス学会総会  2023.11 

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    Research and development towards the feasibility of ureteroscopy-assisted robots

  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention.

    Kobayashi S

    36th International Congress Computer Assisted Radiology and Surgery.  2022.6 

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    Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention.

  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention

    Kobayashi S

    Radiology Research Symposium 2022  2022.5 

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    Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention

  • da Vinci Surgical System Xiにおける3次元画像と光学式追跡システムを併用した自動追尾型手術 ナビゲーション開発 -ナビゲーションの標準化に向けて- Invited

    小林聡

    日本泌尿器内視鏡・ロボティクス学会  2021.11 

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    Development of automatic tracking surgical navigation using 3D images and an optical tracking system in the da Vinci Surgical System Xi -Toward standardization of navigation-

  • ナビゲーションシステムを用いたRAPNの実践

    小林聡

    日本泌尿器内視鏡・ロボティクス学会  2021.11 

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    Practice of RAPN using navigation system

  • マイクロマニピュレータを搭載したレゼクトスコープ

    中楯 龍, 牟田口淳, 小林 聡, 荒田純平, 大澤啓介, 長尾吉泰, 赤星朋比古, 江藤正俊

    第30回コンピュータ外科学会  2021.11 

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    Resectoscope with micromanipulator

  • RAPNにおけるナビゲーションシステムの有効性 -ナビゲーショ ンで手術はどう変化したのか- Invited

    小林聡

    第13回日本ロボット外科学会  2020.1 

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    Effectiveness of the navigation system in RAPN -How has navigation changed surgery-

  • RAPNにおける手術戦略:3D画像術中ナビゲーションの導入

    猪口淳一, 小林聡

    第34回日本泌尿器内視鏡学会総会  2020.11 

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    Surgical Strategy in RAPN: Introduction of 3D Imaging Intraoperative Navigation

  • The preservation of more normal renal parenchyma improves the operated renal function decreased by partial nephrectomy.

    Kobayashi S

    108th The Japanese Urological Association  2020.12 

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    The preservation of more normal renal parenchyma improves the operated renal function decreased by partial nephrectomy.

  • ロボット支援腎部分切除術における手術ナビゲーションは患側腎を温存する.

    牟田口淳, 小林聡

    第34回日本泌尿器内視鏡学会総会  2020.11 

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    Surgical navigation in robot-assisted partial nephrectomy preserves the affected kidney.

  • 当院におけるロボット手術におけるナビゲーション開発の動向 Invited

    小林聡

    第17回泌尿器再建再生研究会  2020.9 

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    Trends in navigation development in robotic surgery at our hospital

  • 膀胱内視鏡における画像支援に用いる人工知能アルゴリズム検討

    牟田口淳, 小林聡

    第108回日本泌尿器科学会総会  2020.12 

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    Investigation of artificial intelligence algorithm used for image support in cystoendoscopy

  • Assessment of surgical skills by using surgical navigation in robot-assisted partial nephrectomy.

    Kobayashi S

    33st International Congress and Exhibition of Computer Assisted Radiology and Surgery  2019.6 

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    Assessment of surgical skills by using surgical navigation in robot-assisted partial nephrectomy.

  • Development of next-generation surgical navigation system in Robot-assisted partial nephrectomy

    Kobayashi S

    第71回西日本泌尿器科学会総会  2019.11 

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    Development of next-generation surgical navigation system in Robot-assisted partial nephrectomy

  • Novel robotic navigation system Invited

    Kobayashi S

    The Hong Kong Congress of Endourology  2019.6 

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    Novel robotic navigation system

  • RAPNへの拡張現実 Augmented Reality手術ナビゲーションシステム開発

    小林聡

    第32回日本内視鏡外科学会総会  2019.12 

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    Augmented Reality to RAPN Augmented Reality Surgical Navigation System Development

  • Tri-Scan強調画像を用いたU-Netによる膀胱鏡画像からの腫瘍検出

    楳原愛子, 諸岡健一, 牟田口淳, 小林 聡, 宮内翔子, 倉爪亮, 江藤正俊

    日本コンピュータ外科学会誌  2019.11 

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    Tumor detection from cystoscopic images by U-Net using Tri-Scan-enhanced images

  • ロボット支援腎部分切除術 ~腎機能温存への工夫~

    小林聡

    第32回日本内視鏡外科学会総会  2019.12 

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    Robot-assisted partial nephrectomy ~Ingenuity for preserving renal function~

  • ロボット支援腎部分切除術における手術ナビゲーションは患側腎を温存する

    小林聡

    第29回九州内視鏡下手術手技研究会  2019.12 

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    Surgical navigation in robot-assisted partial nephrectomy preserves the affected kidney

  • ロボット支援腎部分切除術における手術ナビゲーションは患側腎を温存する

    小林聡

    第32回日本泌尿器内視鏡学会総会  2018.11 

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    Surgical navigation in robot-assisted partial nephrectomy preserves the affected kidney

  • ロボット支援腎部分切除術における自動追従型手術ナビゲーションの有効性についての検討

    小林聡

    第106回日本泌尿器科学会総会  2018.4 

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    Examination of the effectiveness of automatic tracking type surgical navigation in robot-assisted partial nephrectomy

  • 当院における腎門部腫瘍の工夫-RAPNにおける手術ナビゲーション- Invited

    小林聡

    第32回日本泌尿器内視鏡学会総会  2018.11 

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    Ingenuity of renal hilum tumor in our hospital - Surgical navigation in RAPN -

  • SURGICAL NAVIGATION USING INTUITIVE IMAGE-TO-PATIENT REGISTRATION FOR ROBOT-ASSISTED PARTIAL NEPHRECTOMY

    Kobayashi S

    15th Urological Association of Asia Congress  2017.8 

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    SURGICAL NAVIGATION USING INTUITIVE IMAGE-TO-PATIENT REGISTRATION FOR ROBOT-ASSISTED PARTIAL NEPHRECTOMY

  • Surgical Navigation using Intuitive Image-to-Patient Registration for Robot-Assisted Partial Nephrectomy: Clinical Feasibility study.

    Kobayashi S

    35th World Congress of Endourology  2017.11 

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    Surgical Navigation using Intuitive Image-to-Patient Registration for Robot-Assisted Partial Nephrectomy: Clinical Feasibility study.

  • Surgical navigation using intuitive image-to-patient registration for robot-assisted partial nephrectomy: clinical feasibility study

    Kobayashi S

    31st International Congress and Exhibition of Computer Assisted Radiology and Surgery  2017.9 

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    Surgical navigation using intuitive image-to-patient registration for robot-assisted partial nephrectomy: clinical feasibility study

  • ナビゲーションによるRAPN適応拡大 Invited

    小林聡

    第31回日本泌尿器内視鏡学会総会  2017.11 

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    Expanding RAPN indications through navigation

  • 九州大学におけるロボット手術ナビゲーション開発と臨床応用.

    小林聡

    第27回九州内視鏡下外科手術研究会  2017.9 

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    Robotic Surgical Navigation Development and Clinical Application at Kyushu University

  • 九州大学におけるロボット手術ナビゲーション開発への挑戦

    小林聡

    第9回日本ロボット外科学会学術集会  2017.1 

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    Challenge to develop robotic surgical navigation at Kyushu University

  • 自動追従型手術ナビゲーションシステムのロボット支援腎部分切除術への応用と今後の展望

    小林聡

    第105回日本泌尿器科学会総会  2017.4 

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    Application of automatic tracking type surgical navigation system to robot-assisted partial nephrectomy and future prospects

  • 下部尿管癌に対するロボット支援下尿管・膀胱部分切除、膀胱尿管新吻合術の初期経験

    松元 崇, 猪口 淳一, 塚原 茂大, 種子島 時祥, 牟田口 淳, 後藤 駿介, 小林 聡, 塩田 真己, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2024.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • 腎シンチグラフィを用いたロボット支援腎部分切除術後の患側腎機能の検討

    元 貴彦, 牟田口 淳, 種子島 時祥, 塚原 茂大, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2024.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • 泌尿器科手術の新時代テクノロジーの開発と展望 軟性尿管鏡からロボット支援尿管鏡へのパラダイムシフトは起きるのか?

    小林 聡

    日本泌尿器内視鏡・ロボティクス学会総会  2024.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention.

    Kobayashi S

    36th International Congress Computer Assisted Radiology and Surgery.  2022.6 

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  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention

    Kobayashi S

    Radiology Research Symposium 2022  2022.5 

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    Presentation type:Oral presentation (general)  

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  • NBI膀胱鏡画像における物体検出システムの精度比較(Accuracy Comparison of Object Detection System in NBI Cystoscopic Images)

    Mutaguchi Jun, Oda Masahiro, Goto Shunsuke, Kobayashi Satoshi, Matsumoto Takashi, Shiota Masaki, Inokuchi Junichi, Mori Kensaku, Eto Masatoshi

    日本泌尿器科学会総会  2024.4  (一社)日本泌尿器科学会総会事務局

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  • MRI/ultrasound fusion-targeted生検を併用したsystematic前立腺生検の有用性についての検討

    種子島 時祥, 塩田 真己, Blas Leandro, 塚原 茂大, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 江藤 正俊

    日本腎泌尿器疾患予防医学研究会プログラム・抄録集  2024.7  日本腎泌尿器疾患予防医学研究会

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  • Advances in robotic surgery for RCC: RAPN for complicated tumors and RARN for IVC tumor thrombus T1b腫瘍に対するRAPN(RAPN for patients with T1b renal tumors)

    Kobayashi Satoshi

    日本泌尿器科学会総会  2024.4  (一社)日本泌尿器科学会総会事務局

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  • 転移性腎細胞癌に対するイピリムマブ+ニボルマブ療法の予後因子に関する検討

    門司 恵介, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 猪口 淳一, 江藤 正俊

    日本癌治療学会学術集会抄録集  2023.10  (一社)日本癌治療学会

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  • 転移性去勢抵抗性前立腺癌患者におけるアンドロゲン受容体シグナル伝達阻害剤の有効性に対するプロトンポンプ阻害剤の影響

    種子島 時祥, 塩田 真己, 塚原 茂大, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 江藤 正俊

    西日本泌尿器科学会総会抄録集  2024.10  (一社)西日本泌尿器科学会

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  • 膀胱内再発を来す腎盂尿管癌における原発巣免疫微小環境の解析(Analysis of Tumor Immune Microenvironment in the Upper Tract Urothelial Carcinoma with Intravesical Recurrence)

    伊藤 大輔, 種子島 時祥, 奥村 元紀, 板橋 耕太, 塚原 茂大, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 小山 正平, 西川 博嘉, 江藤 正俊, 江藤 正俊

    日本癌学会総会記事  2024.9  (一社)日本癌学会

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  • 膀胱内再発を伴う上部尿路上皮癌における腫瘍免疫微小環境の解析(Analysis of Tumor Immune Microenvironment in the Upper Tract Urothelial Carcinoma with Intravesical Recurrence)

    伊藤 大輔, 種子島 時祥, 板橋 耕太, 奥村 元紀, 塚原 茂大, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 小山 正平, 西川 博嘉, 江藤 正俊

    西日本泌尿器科学会総会抄録集  2024.10  (一社)西日本泌尿器科学会

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  • 腎部分切除によって診断された転移性甲状腺濾胞癌の一例

    塚原 茂大, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    日本内分泌外科学会雑誌  2024.4  (一社)日本内分泌外科学会

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  • 腎癌診療における3D画像生成に向けた自動セグメンテーションシステム開発(Development of an automatic segmentation system for 3D image generation in renal cancer treatment)

    Kobayashi Satoshi, Tsukino Keiji, Mutaguchi Jun, Goto Shunsuke, Matsumoto Takashi, Shiota Masaki, Inokuchi Junichi, Eto Masatoshi

    日本泌尿器科学会総会  2024.4  (一社)日本泌尿器科学会総会事務局

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  • 腎癌診療における3D画像生成に向けた自動セグメンテーションシステム開発

    小林 聡, 月野 圭治, 牟田口 淳, 塚原 茂大, 種子島 時祥, 後藤 駿介, 松元 崇, 塩田 真己, 江藤 正俊

    日本コンピュータ外科学会誌  2024.10  (一社)日本コンピュータ外科学会

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  • 百花繚乱-小径腎癌の治療戦略- 小径腎癌に対する腎部分切除術の意義

    猪口 淳一, 小林 聡, 牟田口 淳, 門司 恵介, 塩田 真己, 江藤 正俊

    日本癌治療学会学術集会抄録集  2023.10  (一社)日本癌治療学会

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  • 異所性ACTH産生前立腺小細胞癌の一例

    藤本 雄史, 種子島 時祥, 福地 源司郎, 牟田口 淳, 塚原 茂大, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊, 松尾 玲奈, 小川 佳宏

    西日本泌尿器科  2025.1  (一社)西日本泌尿器科学会

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  • 理想のロボット支援下腎部分切除(RAPN)を目指して 鉗子情報を取り入れた手術ナビゲーションシステムの開発

    月野 圭治, 小林 聡, 小栗 晋, 牟田口 淳, 塚原 茂大, 種子島 時祥, 後藤 駿介, 松元 崇, 塩田 真己, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2024.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • 末期腎疾患のゲノム解析(Genomic analysis of end-stage renal disease)

    家入 康輔, 垣内 伸之, 高松 大, 牟田口 淳, 小林 聡, 後藤 駿介, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 井元 清哉, 小川 誠司, 江藤 正俊

    西日本泌尿器科学会総会抄録集  2023.11  (一社)西日本泌尿器科学会

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  • 当院における完全埋没型腫瘍に対するロボット支援腎部分切除術の治療成績

    牟田口 淳, 種子島 時祥, 塚原 茂大, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊

    腎癌研究会会報  2024.7  (一社)腎癌研究会

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  • 当院におけるディスポーザブル尿管鏡を用いたfTUL症例の治療成績

    魚住 友治, 上田 翔平, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    日本尿路結石症学会学術集会プログラム・抄録集  2023.8  日本尿路結石症学会

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  • 当院でのI-O時代における非淡明細胞型腎癌に対する薬物療法の治療成績

    後藤 駿介, 種子島 時祥, 塚原 茂大, 牟田口 淳, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊

    腎癌研究会会報  2024.7  (一社)腎癌研究会

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  • 当院でのI-O時代における非淡明細胞型腎癌に対する薬物療法の治療成績

    後藤 駿介, 牟田口 淳, 小林 聡, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    日本癌治療学会学術集会抄録集  2023.10  (一社)日本癌治療学会

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  • 尿路上皮癌に対するアベルマブ維持療法の初期経験

    松元 崇, 牟田口 淳, 塚原 茂大, 種子島 時祥, 後藤 駿介, 小林 聡, 塩田 真己, 江藤 正俊

    日本癌治療学会学術集会抄録集  2024.10  (一社)日本癌治療学会

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  • Research and development towards the feasibility of ureteroscopy-assisted robots

    Satoshi Kobayashi, Buntaro Masaki, Franklin King, Daniel A Wollin, Adam Stuart Kibel, Nobuhiko Hata, Masatoshi Eto

    Japanese Society of Endourology and Robotics  2023.11 

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  • 尿管鏡支援ロボットの実現可能性に向けた開発研究

    小林 聡, 正木 文太郎, キング・フランクリン , ダン・ウーリン , カイベル・アダム , 波多 伸彦, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2023.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • 尿管鏡支援ロボットの実現可能性に向けた開発研究

    小林 聡, 正木 文太郎, King Franklin, Wollin Daniel A, Kibel Adam Stuart, 波多 信彦, 江藤 正俊

    日本尿路結石症学会学術集会プログラム・抄録集  2024.8  日本尿路結石症学会

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  • 尿中cell-free DNAを用いた非筋層浸潤性膀胱癌に対する再発モニタリング

    永川 祥平, 塚原 茂大, 牟田口 淳, 種子島 時祥, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊

    西日本泌尿器科学会総会抄録集  2024.10  (一社)西日本泌尿器科学会

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  • 副腎Primary Pigmented Nodular Adrenocortical Diseaseの一例

    松隈 啓人, 後藤 駿介, 牟田口 淳, 小林 聡, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    西日本泌尿器科  2024.6  (一社)西日本泌尿器科学会

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  • 前立腺癌に対する重粒子線治療後のロボット支援下救済手術

    塚原 茂大, 塩田 真己, 種子島 時祥, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 猪口 淳一, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2024.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • 前立腺癌に対する重粒子線治療後のサルベージロボット支援手術(Salvage robot-assisted surgery after carbon ion radiotherapy to the prostate cancer)

    Tsukahara Shigehiro, Shiota Masaki, Takamatsu Dai, Tanegashima Tokiyoshi, Ueda Shohei, Goto Shunsuke, Kobayashi Satoshi, Matsumoto Takashi, Inokuchi Junichi, Shioyama Yoshiyuki, Eto Masatoshi

    日本泌尿器科学会総会  2024.4  (一社)日本泌尿器科学会総会事務局

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  • 前立腺癌に対する拡大骨盤リンパ節郭清側の最適化

    塩田 真己, 新保 正貴, 塚原 茂大, 種子島 時祥, 後藤 駿介, 小林 聡, 松元 崇, 服部 一紀, 遠藤 文康, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2024.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • 免疫チェックポイント阻害薬を含む薬物療法後に手術を施行した腎癌症例の治療成績

    後藤 駿介, 種子島 時祥, 塚原 茂大, 牟田口 淳, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2024.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • 免疫チェックポイント阻害剤を含む薬物療法後に手術を施行した腎癌症例の治療成績

    後藤 駿介, 牟田口 淳, 小林 聡, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    西日本泌尿器科学会総会抄録集  2023.11  (一社)西日本泌尿器科学会

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  • 九州大学泌尿器科学教室における2023年の臨床統計

    辻田 次郎, 種子島 時祥, 塚原 茂大, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊

    西日本泌尿器科  2025.1  (一社)西日本泌尿器科学会

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  • 九州大学泌尿器科学教室における2022年の臨床統計

    魚住 友治, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    西日本泌尿器科  2024.1  (一社)西日本泌尿器科学会

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  • 非翻訳領域のホットスポット変異解析による筋浸潤性膀胱癌の病勢評価

    塚原 茂大, 塩田 真己, 松元 崇, 永川 祥平, 種子島 時祥, 牟田口 淳, 小林 聡, 内海 健, 兒玉 啓補, 江藤 正俊

    日本癌治療学会学術集会抄録集  2024.10  (一社)日本癌治療学会

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  • 非筋層浸潤性膀胱癌におけるBCG療法後の進行に対する遺伝子リスクモデルの検証(Independent validation of genetic risk model to progression after intravesical BCG therapy for NMIBC)

    永川 祥平, 塩田 真己, 塚原 茂大, 種子島 時祥, 上田 翔平, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 江藤 正俊, 塩田 真己

    日本癌学会総会記事  2024.9  (一社)日本癌学会

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  • ロボット支援膀胱全摘術における体腔内回腸導管造設術の早期周術期成績

    松元 崇, 牟田口 淳, 後藤 駿介, 小林 聡, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2023.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • ディープラーニングを用いた膀胱癌拡大観察による深達度診断アルゴリズムの構築

    牟田口 淳, 小田 昌宏, 後藤 駿介, 小林 聡, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 森 健策, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2023.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • ロボット支援腎部分切除術における鉗子情報を取り入れた術中ナビゲーションシステムの開発

    月野 圭治, 小林 聡, 小栗 晋, 牟田口 淳, 塚原 茂大, 種子島 時祥, 後藤 駿介, 松元 崇, 塩田 真己, 江藤 正俊

    日本コンピュータ外科学会誌  2024.10  (一社)日本コンピュータ外科学会

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  • ロボット支援根治的膀胱全摘術における尿路変更術式の比較検討

    魚住 友治, 牟田口 淳, 小林 聡, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    日本内視鏡外科学会雑誌  2023.12  (一社)日本内視鏡外科学会

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  • ロボット支援手術内視鏡画像から3D臓器モデル画像を出力する画像変換モデルの構築

    月野 圭治, 宮内 翔子, 小林 聡, 小栗 晋, 牟田口 淳, 塚原 茂大, 後藤 駿介, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 沖 英次, 倉爪 亮, 江藤 正俊

    日本コンピュータ外科学会誌  2023.11  (一社)日本コンピュータ外科学会

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  • Construction of an image conversion model that outputs 3D organ model images from robot-assisted surgery endoscopic images

    Keiji Tsukino, Shoko Miyauchi, Satoshi Kobayashi, Susumu Oguri, Jun Mutaguchi, Shigehiro Tsukahara, Shunsuke Goto, Takashi Matsumoto, Keisuke Moji, Maki Shioda, Junichi Inoguchi, Eiji Oki, Ryo Kurazume, Masatoshi Eto

    32nd Annual Meeting of the Japanese Society of Computerized Surgery  2023.12 

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  • Development of automatic tracking attachment for RAPN navigation

    Keiji Tsukino, Satoshi Kobayashi, Jun Mutaguchi, Takashi Matsumoto, Keisuke Moji, Mami Shioda, Junichi Inoguchi, Eiji Oki, Masatoshi Eto

    37th Annual Meeting of Japanese Society of Endourology and Robotics  2023.11 

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  • RAPNナビゲーションにおける自動追尾用アタッチメントの開発

    月野 圭治, 小林 聡, 牟田口 淳, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 沖 英次, 江藤 正俊

    日本泌尿器内視鏡・ロボティクス学会総会  2023.11  (一社)日本泌尿器内視鏡・ロボティクス学会

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  • Multilocular Cystic Renal Neoplasm of Low Malignant Potentialの1例

    中野 康弘, 小林 聡, 門司 恵介, 牟田口 淳, 後藤 駿介, 松元 崇, 塩田 真己, 猪口 淳一, 小田 義直, 江藤 正俊

    西日本泌尿器科  2024.1  (一社)西日本泌尿器科学会

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  • Attachment for L43K ultrasound probe. Special project for medical-engineering collaboration: Learning about medical-engineering collaboration from successful cases ~ JSER Medical-Engineering Collaboration Award Presentation ~ Invited

    Satoshi Kobayashi

    37th Annual Meeting of Japanese Society of Endourology and Robotics  2023.11 

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  • L43K超音波プローブアタッチメント開発における市販後調査

    小林 聡, 中楯 龍, 宮田 信一, 月野 圭治, 牟田口 淳, 後藤 駿介, 門司 恵介, 塩田 真己, 猪口 淳一, 江藤 正俊

    日本コンピュータ外科学会誌  2023.11  (一社)日本コンピュータ外科学会

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  • Post-marketing survey in the development of L43K ultrasound probe attachment

    Satoshi Kobayashi, Tateryu Naka, Shinichi Miyata, Keiji Tsukino, Jun Mutaguchi, Shunsuke Goto, Keisuke Moji, Maki Shiota, Junichi Inoguchi, Masatoshi Eto

    32nd Annual Meeting of the Japanese Society of Computerized Surgery  2023.12 

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  • 九州大学泌尿器科学教室における2021年から2023年の3年間の臨床統計

    辻田 次郎, 種子島 時祥, 塚原 茂大, 牟田口 淳, 後藤 駿介, 小林 聡, 松元 崇, 塩田 真己, 江藤 正俊

    西日本泌尿器科   87 ( 3 )   110 - 114   2025.2   ISSN:0029-0726

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    九州大学泌尿器科学教室における2021年から2023年の3年間の外来,入院および手術術式に関する統計をまとめた.1)外来患者総数は47,054人で新来2,706人,再来44,348人であり,外来新来患者疾患別頻度では,尿路性器悪性腫瘍1,514人(55.9%),悪性腫瘍等による尿路通過障害207人(7.6%),前立腺肥大症203人(7.5%),神経因性膀胱140人(5.2%),炎症性疾患103人(3.8%),尿路結石症87人(3.2%)の順であった.2)入院患者総数は3,265人で男性2,609人,女性656人で60~70歳代の男性患者が全入院患者の過半数を占めた(57.2%).入院患者疾患別では,尿路性器腫瘍が2,172人(66.5%)と最も多く,膀胱癌,前立腺癌,腎癌,腎盂尿管癌の順であった.次いで前立腺生検目的526人(16.1%),尿路結石症129人(4.0%),副腎腫瘍75人(2.3%)の順であった.3)総手術例数は1,732例で,開放手術32例(1.8%),腹腔鏡手術745例(43.0%)(うちロボット支援下手術503(29.0%)),内視鏡手術例896例(51.7%),その他74例(4.3%)であった.(著者抄録)

  • 泌尿器科領域におけるコンピュータ外科手術の経験

    小林 聡, 牟田口 淳, 月野 圭治, 江藤 正俊

    日本コンピュータ外科学会誌   26 ( 3 )   276 - 280   2025.1   ISSN:1344-9486

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  • 腎細胞癌に対する免疫療法の現状と将来展望(Current status and future perspective of immunotherapy for renal cell carcinoma)

    Blas Leandro, Monji Keisuke, Mutaguchi Jun, Kobayashi Satoshi, Goto Shunsuke, Matsumoto Takashi, Shiota Masaki, Inokuchi Junichi, Eto Masatoshi

    International Journal of Clinical Oncology   29 ( 8 )   1105 - 1114   2024.8   ISSN:1341-9625

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  • 【ロボット支援手術-標準治療としてのさらなる普及を目指して-】泌尿器科領域のロボット支援手術 腎部分切除術 手術ナビゲーションシステムの進歩

    月野 圭治, 小林 聡, 牟田口 淳, 猪口 淳一, 江藤 正俊

    日本臨床   82 ( 増刊1 ロボット支援手術 )   80 - 85   2024.1   ISSN:0047-1852

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  • Construction of An Image Conversion Model to Generate 3D Organ Model Images from Robot-assisted Surgery Endoscopic Images

    月野圭治, 月野圭治, 宮内翔子, 小林聡, 小栗晋, 牟田口淳, 塚原茂大, 後藤駿介, 松元崇, 門司恵介, 塩田真己, 猪口淳一, 沖英次, 沖英次, 倉爪亮, 江藤正俊

    日本コンピュータ外科学会誌(Web)   25 ( 3 )   2023   ISSN:1884-5770

  • 【RAPNにおけるシミュレーションおよびナビゲーションシステムの活用】ナビゲーションシステムを用いたRAPNの実践

    小林 聡, 月野 圭治, 李 賢, 門司 恵介, 柏木 英志, 塩田 真己, 猪口 淳一, 江藤 正俊

    Japanese Journal of Endourology and Robotics   35 ( 2 )   198 - 202   2022.9

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    腎腫瘍は局在と形態は多岐にわたり,腎血管の数と形態にも個体差がある.従って,ロボット支援腎部分切除術(robot-assisted partial nephrectomy;RAPN)では多様な解剖学的特徴を踏まえ手術のアプローチ方法を術前に計画しておく必要がある.この術前計画において,医療画像から作成された腎癌3D画像は,腎腫瘍や腎血管の情報を視覚的に理解するのに役立ち,この画像を使った3次元的な解剖理解によって腎動脈の遮断予定部位,温存可能な血管の確認と腫瘍切除に伴う尿路の損傷範囲を予測することが可能となり,詳細な術前計画を立てることができる.しかし,3D画像を生成するためには,医用画像解析ワークステーションとソフトウエアが必要となり,これらを扱うための専門知識がユーザーには求められる.また,多様なソフトウエアをクラウドベースまたはサブスクライブされたアプリケーションの中から,ユーザーの用途に合わせて選択しなければならない.そして,ユーザーはソフトウエアを使って腎臓,腫瘍,腎血管や尿路をセグメンテーションしてラベルデータを作成し,このデータをレンダリングして3D画像を作成することになる.従って,ソフトウエアを使った腎癌3D画像の作成は,RAPNのナビゲーションを実施する上で重要でかつ最初のタスクである.しかし,このタスクを遂行する上で,多くの医療者は医療解析ソフトの特性からその操作方法に至るまでの知識と経験を持ち合わせていない場合があり,3D画像を使ったRAPNのナビゲーションの導入についてハードルが高く感じていることがある.本稿では,ナビゲーションを実践するために重要な腎癌3D画像の作成について,最新の知見を含め報告する.(著者抄録)

  • RAPNにおける術中ナビゲーションの現状と展望

    猪口淳一, 牟田口淳, 小林聡, 柏木英志, 武内在雄, 塩田真己, 江藤正俊

    日本ロボット外科学会学術集会プログラム・抄録集   14th   2022

  • "特集 今こそ知りたい!ロボット時代の腹腔鏡手術トレーニング -腹腔鏡技術認定を目指す泌尿器科医のために<特別付録Web動画>  <腹腔鏡手術トレーニングにおける技術の活用>  内視鏡手術におけるVR・ARの有用性." Reviewed

    @小林聡、@猪口淳一、@江藤正俊:

    臨床泌尿器科 75 (10): 752-756, 2021   2021.9

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  • Editorial Comment to Endoscopic laser treatment for urine leakage caused by an isolated calyx after robot-assisted partial nephrectomy Reviewed

    @Kobayashi S, @Shiota M.

    IJU Case Rep. 2021 Sep 12;4(6):346. doi: 10.1002/iju5.12349. eCollection 2021 Nov.   2021.9

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  • RAPNにおける術中ナビゲーションの現状と今後の展望. Reviewed

    @猪口淳一、@小林 聡、@牟田口 淳、@江藤正俊:

    泌尿器科 13 (3): 356-362, 2021   2021.3

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  • Reply by Authors Reviewed

    @Kobayashi S, @Cho B, @Mutaguchi J, @Inokuchi J, @Tatsugami K, @Hashizume M, @Eto M.

    J Urol. 2020 Jul;204(1):156. doi: 10.1097/JU.0000000000000709.02. Epub 2020 Apr 23.   2020.7

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Works

  • Ultrasonic probe attachment

    Satoshi Kobayashi

    2020.10 - Present

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Professional Memberships

  • EAU European Association of Urology

    2024.12 - Present

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  • Endourological Association

    2024.9 - Present

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  • UAA urological association of urology

    2024.9 - Present

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  • Japanese Society for Medical and Biological Engineering

    2019.4 - Present

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  • Japan Robotic Surgery Society

    2016.4 - Present

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  • Japan Society of Urologic Oncology

    2016.4 - Present

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  • International Journal of Clinical Oncology

    2012.4 - Present

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  • Japanese. Society of Endourology and Robotics

    2010.4 - Present

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  • The Japanese Urological Association

    2010.4 - Present

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  • Japanese Society for Medical and Biological Engineering

  • Japan Robotic Surgery Society

  • Japan Society of Urologic Oncology

  • International Journal of Clinical Oncology

  • Japanese. Society of Endourology and Robotics

  • The Japanese Urological Association

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Committee Memberships

  • Japanese Society of Endourology and Robotics   Executive Committee Member of Medical Engineering Collaboration and New Technology Review Committee  

    2024.12 - Present   

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  • Japan Society of Computer Aided Surgery   Program Committee Member for the 33rd Japan Society of Computer Aided Surgery  

    2024.5   

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    Committee type:Academic society

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  • 第37回日本内視鏡外科学会総会   エキスパートコンセンサス会議 Research Committee  

    2024.4 - Present   

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  • Japanese Society of Urological Endoscopy and Robotics   representative  

    2024.4 - Present   

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  • Japanese Society of Endourology and Robotics   Robot Telesurgery Research and Development Application Committee  

    2023.4   

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    Committee type:Academic society

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Academic Activities

  • 座長

    第111回日本泌尿器科学会総会  ( Japan ) 2024.4 - 2024.5

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    Type:Competition, symposium, etc. 

    Number of participants:10

  • 西日本泌尿器科学会

    2023.4 - 2028.5

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    Type:Academic society, research group, etc. 

Research Projects

  • ロボット支援腎部分切除術の視覚と聴覚に訴える手術ナビゲーションシステム開発研究

    Grant number:25K15937  2025.4 - 2029.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    小林 聡

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    Grant type:Scientific research funding

    CiNii Research

  • 尿管鏡支援ロボットの社会実装に向けたAI-based SaMD開発研究

    2024.9 - 2025.8

    日本泌尿器内視鏡・ロボティクス学会 助成

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    Authorship:Principal investigator 

  • 尿管鏡支援ロボットの実現可能性に向けた開発研究

    2024.8

    内視鏡医学研究医海外派遣助成

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    Authorship:Principal investigator 

  • 遠隔医療の実現に向けた腎癌AI画像支援システム・クラウドマイグレーション開発研究

    2024.5 - 2024.12

    日本泌尿器科学会 ヤングリサーチグラント 助成

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    Authorship:Principal investigator 

  • 腎癌患者における遠隔支援を目指した包括的なAI画像支援システム開発に関する研究

    2024.4 - 2025.3

    医療機器センター 助成

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    Authorship:Principal investigator 

  • Research and development of hybrid image-guided system with AI for kidney cancer

    Grant number:23K19219  2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity start-up

    小林 聡

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    Authorship:Principal investigator  Grant type:Scientific research funding

    本申請課題はロボット支援腎部分切除術を受ける患者の腎機能温存を目指すためにAIを使って画像支援技術を開発することである.具体的には腎腫瘍の組織型予測モデルと腎腫瘍3D画像を自動生成するモデルを開発し、ロボット支援腎部分切除術を受ける患者の臨床的な有効性を腎機能の観点から評価していく. 元来、腎癌診療においてAIがどのようなメリットがあるか明確に評価されていないため、申請課題の本質は、腎癌診療におけるAIの実現可能性について探索する研究であるとともに、Society5.0に向けた泌尿器科領域における新たなアプローチを提案することである.

    CiNii Research

  • AIによる自動registration機能を搭載した新しいRAPNナビゲーションシステムの開発

    2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 腎癌診療におけるハイブリットAI画像支援技術の開発研究

    2023 - 2024

    Japan Society for the Promotion of Science  研究活動スタート支援

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    Grant type:Joint research

  • 腎癌診療における遠隔医療に向けたハイブリットAI画像支援技術のクラウドマイグレーション開発研究

    2023 - 2024

    西川医療振興財団助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 腎機能温存を目的とした腎癌診療におけるハイブリットAI画像支援技術の開発研究

    2023 - 2024

    臨床研究奨励基金 助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 腎癌診療における腎機能温存を主軸としたハイブリットAI画像支援技術の開発研究

    2023 - 2024

    鈴木謙三記念医科学応用研究財団助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 手術ナビゲーション開発に関する研究.

    2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 手術用支援ロボット da Vinci Xi における拡張現実(Augmented Reality)と仮想現実(Virtual Reality)を 融合した次世代型手術ナビゲーション開発とロボット支援腎部分切除術への導入

    2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • da Vinci Surgical System Xiにおける3次元画像と光学式追跡システムを併用した自動追尾型手術ナビゲーション開発-ナビゲーションの標準化に向けて

    2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ロボット支援腎部分切除術に向けた腹部CT画像における深層学習による腎癌画像診断システムと3D腎癌画像構築システム開発

    2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ロボット支援腎部分切除におけるAR手術ナビゲーション開発・臨床導入

    Grant number:19K20713  2019 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

  • Surgical Navigation using Intuitive Image-to-Patient Registration for Robot-Assisted Partial Nephrectomy: Clinical Feasibility study

    2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ロボット支援腎部分切除術における手術ナビゲーションの臨床応用と検討

    2016 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Educational Activities

  • 泌尿器科学

Media Coverage

  • 泌尿器科の最先端技術の紹介 Newspaper, magazine

    2024年福岡の頼れるお医者さん  2024.1

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    泌尿器科の最先端技術の紹介

Travel Abroad

  • 2021.4 - 2023.3

    Staying countory name 1:United States   Staying institution name 1:Harvard Medical School

    Staying institution name 2:Brigham and Women's Hospital