Updated on 2024/11/27

Information

 

写真a

 
KOBAYASHI SATOSHI
 
Organization
Kyushu University Hospital Urology Lecturer
School of Medicine Department of Medicine(Concurrent)
Title
Lecturer

Degree

  • Ph.D.

Research Interests・Research Keywords

  • Research theme: Urology Medical-Engineering Collaboration Artificial Intelligence

    Keyword: Urology AI

    Research period: 2023.4 - 2033.5

Awards

  • 第18回ヤングリサーチグラントアワード

    2024.4   日本泌尿器科学会   18th Young Research Grant Award

  • 第21回総会賞

    2020.11   日本泌尿器内視鏡・ロボティス学会   21st General Assembly Award

  • 第11回学会賞

    2020.11   日本泌尿器内視鏡・ロボティス学会   11th Society Award

  • 第71回日本泌尿器科学会西日本総会 ヤングリサーチコンテスト

    2019.11   日本泌尿器科学会   71st Japanese Urological Association West Japan General Assembly Young Research Contest

  • 研究奨励賞

    2019.9   九州内視鏡・ロボット外科手術研究会   Research Encouragement Award

  • 名誉賞

    2019.6   香港内視鏡学会   Honorary Award

  • 2019年度臨床応用研究賞・荻野賞

    2019.4   日本生体医工学会   Clinical Application Research Award, Ogino Award

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Papers

  • Functional outcomes in robot-assisted partial nephrectomy with three-dimensional images reconstructed from computed tomography: a propensity score-matched comparative analysis. Reviewed International journal

    Satoshi Kobayashi, Keiji Tsukino, Jun Mutaguchi, Tokiyoshi Tanegashi, Shunsuke Goto, Takashi Matsumoto, Masaki Shiota, Masatoshi Eto

    Journal of robotic surgery   18 ( 1 )   314 - 314   2024.8   ISSN:1863-2483 eISSN:1863-2491

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Robotic Surgery  

    Our objective was to investigate the long-term functional outcomes of robot-assisted partial nephrectomy (RAPN) combined with three-dimensional (3D) imaging. The 3D images, reconstructed using computed tomography, were introduced in RAPN procedures. The demographic, oncological, functional, and volumetric outcomes of 296 patients who underwent RAPN with and without 3D imaging between 2013 and 2021 were analyzed retrospectively. Propensity score matching (1:1) was performed to adjust for potential baseline confounders. After matching, 71 patients were allocated to each group. In the 3D RAPN (3DRPN) group, functional outcomes significantly improved: the number of patients with over 90% estimated glomerular filtration rate (eGFR) preservation rate (40 vs. 43, P = 0.044), eGFR preservation rate (88.0% vs. 91.6%, P = 0.006), the number of patients with chronic kidney disease (CKD) upstaging (26 vs. 13, P = 0.023), and split renal function preservation rate (operated kidney: 84.9% vs. 88.5%, P = 0.015). The 3DRPN group showed superiority in terms of >90% eGFR preservation (P = 0.010), CKD upstaging-free survival rates (P < 0.001), and volumetric outcomes (excess parenchymal volume: 27.9 vs. 17.7 mL, P = 0.030; parenchyma volume preservation rate: 81.6% vs. 88.8%, P = 0.006). Three-dimensional imaging was positively associated with eGFR preservation (P = 0.023, odds ratio: 2.34) and prevention of CKD upstaging (P = 0.013, odds ratio: 2.90). In this study, RAPN combined with 3D imaging underscored the preservation of eGFR > 90% and the prevention of CKD upstaging by improving the preservation rate of renal parenchyma and split renal function.

    DOI: 10.1007/s11701-024-02070-x

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  • Salvage robot‐assisted radical prostatectomy after carbon ion radiotherapy to the prostate

    Masaki Shiota, Shigehiro Tsukahara, Dai Takamatsu, Tokiyoshi Tanegashima, Shohei Ueda, Leandro Blas, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Junichi Inokuchi, Yoshiyuki Shioyama, Masatoshi Eto

    Asian Journal of Endoscopic Surgery   2024.1

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    DOI: 10.1111/ases.13279

  • Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy to the prostate. Reviewed International journal

    @Shiota M, @Tsukahara S, @Takamatsu D, @Tanegashima T, @Ueda S, #Blas L, @Goto S, @Kobayashi S, @Matsumoto T, @Inokuchi J, @Shioyama Y, @Eto M.

    Asian J Endosc Surg   2024.1

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  • NR5A2/HSD3B1 pathway promotes cellular resistance to second-generation antiandrogen darolutamide. Reviewed International journal

    @Shiota M, @Ushijima M, @Tsukahara S, @Nagakawa S, #Blas L, @Takamatsu D, @Kobayashi S, @Matsumoto T, @Inokuchi J, @Eto M:

    Drug Resist Updat   2023.9

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  • Improved urinary continence recovery after robot-assisted radical prostatectomy with lateral pelvic fascia preservation. International journal

    Masaki Shiota, Shigehiro Tsukahara, Shohei Ueda, Jun Mutaguchi, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Leandro Blas, Keisuke Monji, Junichi Inokuchi, Masatoshi Eto

    Journal of robotic surgery   2023.8

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    The novel technique of lateral pelvic fascia preservation (LPFP) in robot-assisted radical prostatectomy (RARP) has been reported to improve urinary continence recovery. We aimed to investigate surgical and oncological outcomes after RARP using the LPFP technique and compare them with conventional RARP. This study included patients who underwent RARP with and without the LPFP technique. Time to urinary continence recovery was compared between the LPFP and non-LPFP groups using univariate, multivariate, and propensity-score matched analysis. Perioperative and postoperative outcomes were compared between the two groups using univariate analysis. We included 139 patients who underwent RARP, 68 in the LPFP group and 71 in the non-LPFP group. The LPFP technique was associated with a shorter time to urinary continence recovery, a shorter operative time and lower estimated blood loss. Surgical and oncological outcomes, including complications, pathological T-stage, surgical margin status, and biochemical recurrence-free survival, were comparable between the two groups. This study demonstrated that the LPFP technique improves urinary continence recovery and operative times without compromising surgical and oncological outcomes. The use of this technique in patients with clinically localized prostate cancer is recommended.

    DOI: 10.1007/s11701-023-01702-y

  • NR5A2/HSD3B1 pathway promotes cellular resistance to second-generation antiandrogen darolutamide. International journal

    Masaki Shiota, Miho Ushijima, Shigehiro Tsukahara, Shohei Nagakawa, Leandro Blas, Dai Takamatsu, Satoshi Kobayashi, Takashi Matsumoto, Junichi Inokuchi, Masatoshi Eto

    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy   70   100990 - 100990   2023.7

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    This study investigated cellular mechanisms in steroidogenesis responsible for treatment resistance to the novel antiandrogen agent darolutamide in prostate cancer. HSD3B1 was overexpressed in darolutamide-resistant cells and induced by darolutamide treatment and AR knockdown. Inversely, HSD3B1 knockdown increased cellular sensitivity to darolutamide. Similarly, its upstream regulator NR5A2 was up-regulated in darolutamide-resistant cells and induced by darolutamide treatment and AR knockdown. Inversely, NR5A2 knockdown and NR5A2 inhibitor ML180 decreased expression of various steroidogenic enzymes including HSD3B1, leading to increased cellular sensitivity to darolutamide. The NR5A2/HSD3B1 pathway promoted cellular resistance to darolutamide and targeting NR5A2/HSD3B1 pathway is a promising therapeutic strategy to overcome darolutamide resistance.

    DOI: 10.1016/j.drup.2023.100990

  • Feasibility of multi-section continuum robotic ureteroscope in the kidney. Reviewed International journal

    Satoshi Kobayashi, Fumitaro Masaki, Franklin King, Daniel A Wollin, Adam S Kibel, Nobuhiko Hata

    Journal of robotic surgery   2023.1

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    Our objective was to evaluate the feasibility of a multi-section continuum robotic ureteroscope to address the difficulties with access into certain renal calyces during flexible ureteroscopy. First, the robotic ureteroscope developed in previous research, which utilizes three actuated bendable sections controlled by wires, was modified for use in this project. Second, using phantom models created from five randomly selected computer tomography urograms, the flexible ureteroscope and robotic ureteroscope were evaluated, focusing on several factors: time taken to access each renal calyx, time taken to aim at three targets on each renal calyx, the force generated in the renal pelvic wall associated with ureteroscope manipulation, and the distance and standard deviation between the ureteroscope and the target. As a result, the robotic ureteroscope utilized significantly less force during lower pole calyx access (flexible ureteroscope vs. robotic ureteroscope; 2.0 vs. 0.98 N, p = 0.03). When aiming at targets, the standard deviation of proper target access was smaller for each renal calyx (upper pole: 0.49 vs. 0.11 mm, middle: 0.84 vs. 0.12 mm, lower pole: 3.4 vs. 0.19 mm) in the robotic ureteroscope group, and the distance between the center point of the ureteroscope image and the target was significantly smaller in the robotic ureteroscope group (upper: 0.49 vs. 0.19 mm, p < 0.001, middle: 0.77 vs. 0.17 mm, p < 0.001, lower: 0.77 vs. 0.22 mm, p < 0.001). In conclusion, our robotic ureteroscope demonstrated improved maneuverability and facilitated accuracy and precision while reducing the force on the renal pelvic wall during access into each renal calyx.

    DOI: 10.1007/s11701-023-01530-0

  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention. Reviewed International journal

    Satoshi Kobayashi, Franklin King, Nobuhiko Hata

    International journal of computer assisted radiology and surgery   2022.9

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    PURPOSE: Understanding the three-dimensional anatomy of percutaneous intervention in prostate cancer is essential to avoid complications. Recently, attempts have been made to use machine learning to automate the segmentation of functional structures such as the prostate gland, rectum, and bladder. However, a paucity of material is available to segment extracapsular structures that are known to cause needle deflection during percutaneous interventions. This research aims to explore the feasibility of the automatic segmentation of prostate and extracapsular structures to predict needle deflection. METHODS: Using pelvic magnetic resonance imagings (MRIs), 3D U-Net was trained and optimized for the prostate and extracapsular structures (bladder, rectum, pubic bone, pelvic diaphragm muscle, bulbospongiosus muscle, bull of the penis, ischiocavernosus muscle, crus of the penis, transverse perineal muscle, obturator internus muscle, and seminal vesicle). The segmentation accuracy was validated by putting intra-procedural MRIs into the 3D U-Net to segment the prostate and extracapsular structures in the image. Then, the segmented structures were used to predict deflected needle path in in-bore MRI-guided biopsy using a model-based approach. RESULTS: The 3D U-Net yielded Dice scores to parenchymal organs (0.61-0.83), such as prostate, bladder, rectum, bulb of the penis, crus of the penis, but lower in muscle structures (0.03-0.31), except and obturator internus muscle (0.71). The 3D U-Net showed higher Dice scores for functional structures ([Formula: see text]0.001) and complication-related structures ([Formula: see text]0.001). The segmentation of extracapsular anatomies helped to predict the deflected needle path in MRI-guided prostate interventions of the prostate with the accuracy of 0.9 to 4.9 mm. CONCLUSION: Our segmentation method using 3D U-Net provided an accurate anatomical understanding of the prostate and extracapsular structures. In addition, our method was suitable for segmenting functional and complication-related structures. Finally, 3D images of the prostate and extracapsular structures could simulate the needle pathway to predict needle deflections.

    DOI: 10.1007/s11548-022-02757-2

  • Artificial Intelligence for Segmentation of Bladder Tumor Cystoscopic Images Performed by U-Net with Dilated Convolution Invited Reviewed International journal

    @Mutaguchi J, @Morooka K, @Kobayashi S, @Umehara A, @Miyauchi S, @Kinoshita F, @Inokuchi J, @Oda Y, @Kurazume R, @Eto M.

    J Endourol. 2022 Jun;36(6):827-834. doi: 10.1089/end.2021.0483. Epub 2022 May 17.   2022.6

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  • Artificial Intelligence for Segmentation of Bladder Tumor Cystoscopic Images Performed by U-Net with Dilated Convolution. Reviewed International journal

    Jun Mutaguchi, Ken'ichi Morooka, Satoshi Kobayashi, Aiko Umehara, Shoko Miyauchi, Fumio Kinoshita, Junichi Inokuchi, Yoshinao Oda, Ryo Kurazume, Masatoshi Eto

    Journal of endourology   36 ( 6 )   827 - 834   2022.6

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    BACKGROUND: Early intravesical recurrence after transurethral resection of bladder tumors (TURBT) is often caused by overlooking of tumors during TURBT. Although narrow-band imaging and photodynamic diagnosis were developed to detect more tumors than conventional white-light imaging, the accuracy of these systems has been subjective, along with poor reproducibility due to their dependence on the physician's experience and skills. To create an objective and reproducible diagnosing system, we aimed to assess the utility of artificial intelligence (AI) with Dilated U-Net to reduce the risk of overlooked bladder tumors when compared with the conventional AI system, termed U-Net. MATERIAL AND METHODS: We retrospectively obtained cystoscopic images by converting videos obtained from 120 patients who underwent TURBT into 1,790 cystoscopic images. The Dilated U-Net, which is an extension of the conventional U-Net, analyzed these image datasets. The diagnostic accuracy of the Dilated U-Net and conventional U-Net were compared using the following four measurements: pixel-wise sensitivity (PWSe); pixel-wise specificity (PWSp); pixel-wise positive predictive value (PWPPV), representing the AI diagnostic accuracy per pixel; and dice similarity coefficient (DSC), representing the overlap area between the bladder tumors in the ground truth images and segmentation maps. RESULTS: The cystoscopic images were divided as follows, according to the pathological T-stage: 944, Ta; 412, T1; 329, T2; and 116, carcinoma in-situ. The PWSe, PWSp, PWPPV, and DSC of the Dilated U-Net were 84.9%, 88.5%, 86.7%, and 83.0%, respectively, which had improved when compared to that with the conventional U-Net by 1.7%, 1.3%, 2.1%, and 2.3%, respectively. The DSC values were high for elevated lesions and low for flat lesions for both Dilated and conventional U-Net. CONCLUSIONS: Dilated U-Net, with higher DSC values than conventional U-Net, might reduce the risk of overlooking bladder tumors during cystoscopy and TURBT.

    DOI: 10.1089/end.2021.0483

  • Predictive factors of survival outcomes in first-line therapy for metastatic castration-resistant prostate cancer. Reviewed International journal

    Masaki Shiota, Leandro Blas, Satoshi Kobayashi, Takashi Matsumoto, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Ken-Ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    International journal of urology : official journal of the Japanese Urological Association   29 ( 1 )   26 - 32   2022.1

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    OBJECTIVES: To investigate predictive factors of survival of metastatic castration-resistant prostate cancer patients undergoing first-line treatment with androgen receptor pathway inhibitors or docetaxel. METHODS: Japanese patients with metastatic castration-resistant prostate cancer treated with androgen receptor pathway inhibitor or docetaxel between 2008 and 2018 were included. The differential impact of various clinicopathological factors on the outcome, including progression-free survival and overall survival, was compared between treatment with androgen receptor pathway inhibitor and docetaxel. RESULTS: Of 254 patients with metastatic castration-resistant prostate cancer, 119 (46.9%) and 135 (53.2%) were treated with androgen receptor pathway inhibitor and docetaxel, respectively. The multivariate analysis showed that androgen receptor pathway inhibitor was an independent prognostic factor for better progression-free survival (hazard ratio 0.62, 95% confidence interval 0.42-0.92, P = 0.016) and overall survival (hazard ratio 0.61, 95% confidence interval 0.41-0.93, P = 0.021), compared with docetaxel. Pretreatment prostate-specific antigen levels and time to castration-resistant prostate cancer were differentially associated with progression-free survival and overall survival between androgen receptor pathway inhibitor or docetaxel. In patients who presented <6 months to castration-resistant prostate cancer, progression-free survival was shorter in those treated with androgen receptor pathway inhibitor (median 1.1 months, 95% confidence interval 0.2-2.8 months) compared with those who received docetaxel (median 5.0 months, 95% confidence interval 1.8-6.7 months; P = 0.014). CONCLUSIONS: First-line therapy with androgen receptor pathway inhibitor is associated with a better prognosis when compared with docetaxel, even after adjustment for prognostic factors. However, a shorter time to castration-resistant prostate cancer is associated with better progression-free survival for patients receiving docetaxel, suggesting that docetaxel is the preferred option for patients with a shorter time to castration-resistant prostate cancer.

    DOI: 10.1111/iju.14702

  • Differential prognostic impact of complete blood count-related parameters by prior use of novel androgen receptor pathway inhibitors in docetaxel-treated castration-resistant prostate cancer patients. Reviewed International journal

    Hiroki Kobayashi, Masaki Shiota, Nobuaki Sato, Satoshi Kobayashi, Takashi Matsumoto, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Ken-Ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    Anti-cancer drugs   33 ( 1 )   e541-e547   2022.1

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    There are multiple reports on the value of complete blood count (CBC)-related parameters on prognosis in docetaxel-treated castration-resistant prostate cancer (CRPC) patients before the emergence of androgen receptor pathway inhibitors (ARPIs). We investigated the prognostic significance of CBC-related parameters in docetaxel-treated CRPC patients. Patients treated with docetaxel chemotherapy for CRPC between 2008 and 2018 were included. We analyzed the relevance of CBC-related parameters to oncological prognosis in docetaxel chemotherapy, associated with prior use of novel ARPIs. Among 144 Japanese men treated with docetaxel, 49 men (34.0%) had already received ARPI therapy. A high neutrophil-lymphocyte ratio (NLR) was a prognostic factor for poor progression-free survival and overall survival (OS) in both univariate and multivariate analyses. In addition, a low hemoglobin (Hb) level and a high systemic immune-inflammation index (SII) were prognostic factors of poor OS in univariate analysis. Hb level was a prognostic factor of OS in both ARPI-naive and ARPI-treated patients. However, a high NLR and SII were only associated with a poor prognosis in ARPI-naive but not in ARPI-treated patients. Hb, NLR, and SII have been suggested to be prognosticators in docetaxel-treated CRPC patients. The differential prognostic value of NLR and SII between ARPI-naive and ARPI-treated patients may require caution when using these markers in docetaxel-treated CRPC patients.

    DOI: 10.1097/CAD.0000000000001170

  • Differential prognostic impact of complete blood count-related parameters by prior use of novel androgen receptor pathway inhibitors in docetaxel-treated castration-resistant prostate cancer patients Invited Reviewed International journal

    @Kobayashi H, @Shiota M, @Sato N, @Kobayashi S, @Matsumoto T, @Monji K, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Anticancer Drugs. 2022 Jan 1;33(1):e541-e547. doi: 10.1097/CAD.0000000000001170.   2022.1

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  • Predictive factors of survival outcomes in first-line therapy for metastatic castration-resistant prostate cancer Invited Reviewed International journal

    @Shiota M, @Blas L, @Kobayashi S, @Matsumoto T, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Int J Urol. 2022 Jan;29(1):26-32. doi: 10.1111/iju.14702. Epub 2021 Sep 22.   2022.1

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  • Development of ultrasound probe attachment for robot-assisted partial nephrectomy through medical- engineering collaboration

    Satoshi Kobayashi

    Japanese Journal of Endourology and Robotics   2022

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    35:109-118

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  • Editorial Comment to Endoscopic laser treatment for urine leakage caused by an isolated calyx after robot-assisted partial nephrectomy. Reviewed International journal

    Satoshi Kobayashi, Masaki Shiota

    IJU case reports   4 ( 6 )   346 - 346   2021.11

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    DOI: 10.1002/iju5.12349

  • SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study Reviewed

    Dmitri Nepogodiev, Joana F.F. Simoes, Elizabeth Li, James Glasbey, Maria Picciochi, Sivesh K. Kamarajah, Rohan Gujjuri, Aneel Bhangu, A. Maryam, Mohammed A. Azab, Mohammed A. Zahran, Areej A. Abdelaziz, Junaid Aamir, Norhafiza Ab Rahman, Muna Aba Zaid, Muath Abaalkhail, Adnan Ababneh, Hazim Ababneh, Laila Ababneh, Roba Ababneh, Rafael Abad Alonso, Alfredo Abad Gurumeta, Ane Abad-Motos, Mussab Abaker, Ryan Rainiel Abary, Adam Abass, Emmanuele Abate, Sheraz Abayazeed Ahmed, Olukayode Abayomi, Alaa Abazeed, Bader Abbad, Francesco Abbadessa, Osaid Abbadi, Malaz Abbakar, Ahmed M. Abbas, Alzhraa Salah Abbas, Asad Abbas, Aya M. Abbas, Jihad Abbas, Manzar Abbas, Mohammad Monir Abbas, Omer Abbas, Aykhan Abbasov, Olivier Abbo, Daniel Abbott, Tom Abbott, Omar Sudig Abboud, Waleed Abd, Tayma Abd Alghafour, Wael Abd El-Ghani, Mustafa Abd Elsayed, Ahmed Abd Elwahab, Sami Abd Elwahab, Ahmed Yassien Abd-Elkariem, Sherief Abd-Elsalam, Joel Abdala Junior, Ahmad Abdalah, Alya Abdalhadi, Ahmed Abdalla, Eman Adam Abdalla, Samir Abdalla, Shimaa Abdalla, Siddig Abdalla, Emne Abdallah, Ghaida Abdallah, Lubna Abdallah, Munir Abdallah, Rasha Abdallah, Hani Abdalnour, Bashar Abdeen, Saedah Abdeewi, Louai Abdeh, Shrouk Abdel Fattah, Mahmoud Abdel-Aleem, Wafaa Abdel-Elsalam, Areej Abdel-Fattah, Nour Abdel-Fattah, Ibrahim Abdel-Hafez, Abdelrahman Abdelaal, Khaled Abdelazeem, Mohammed Abdelaziz, Mohamad Abdelbagi, Abouelnour Abdelbaset, Hesham Abdeldayem, Mahmoud Abdelfattah, Alwaleed Abdelgadir, Khaled Abdelgalel, Moslem Abdelghafar, Mohammed Abdelhafez, Abdelkarim Abdeljalil, Mohammed Abdelkabir, Ibrahim Abdelkader Salama, Mohamed Abdelkareem, Mohamed M. Abdelkarem, Mostafa Abdelkarim, Mohamed Abdelkhalek, Fatima Abdellah, Ahmed Abdelmajeed, Abubaker Abdelmalik, Ahmed Abdelmawla

    British Journal of Surgery   108 ( 9 )   1056 - 1063   2021.9

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    <jats:title>Abstract</jats:title>
    <jats:sec>
    <jats:title>Background</jats:title>
    <jats:p>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Methods</jats:title>
    <jats:p>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Results</jats:title>
    <jats:p>NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Conclusion</jats:title>
    <jats:p>As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.</jats:p>
    </jats:sec>

    DOI: 10.1093/bjs/znab101

  • Prognostic impact of prior local therapy in castration-resistant prostate cancer Invited Reviewed International journal

    @Koura M, @Shiota M, @Ueda S, @Matsumoto T, @Kobayashi S, @Monji K, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Jpn J Clin Oncol. 2021 Jul 1;51(7):1142-1148. doi: 10.1093/jjco/hyab019.   2021.7

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  • Prognostic impact of prior local therapy in castration-resistant prostate cancer Reviewed International journal

    Mikifumi Koura, Masaki Shiota, Shohei Ueda, Takashi Matsumoto, Satoshi Kobayashi, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Ken-ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    Japanese Journal of Clinical Oncology   51 ( 7 )   1142 - 1148   2021.7

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    <jats:title>Abstract</jats:title>
    <jats:sec>
    <jats:title>Objective</jats:title>
    <jats:p>This study aimed to reveal the prognostic values of prior local therapy in first-line therapy using androgen receptor-axis targeting agents (abiraterone or enzalutamide) or docetaxel for castration-resistant prostate cancer (CRPC).</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Methods</jats:title>
    <jats:p>The study included 303 patients treated with first-line therapy for non-metastatic and metastatic CRPC. The association between prior local therapy and therapeutic outcome including progression-free survival and overall survival was investigated by univariate and multivariate analyses as well as propensity score-matched analysis.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Results</jats:title>
    <jats:p>In univariate analysis, local prior therapy was associated with a lower risk of all-cause mortality (hazard ratio, 0.56, 95% confidence interval, 0.40–0.79; P = 0.0009). Overall survival, but not progression-free survival, was better among patients with prior local therapy compared with patients without prior local therapy even after multivariate analysis and propensity score-matched analysis.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Conclusions</jats:title>
    <jats:p>This study robustly indicated that prior local treatment was prognostic for overall survival among patients with CRPC. This finding is useful to predict patient prognosis in CRPC.</jats:p>
    </jats:sec>

    DOI: 10.1093/jjco/hyab019

  • Prognostic significance of complete blood count parameters in castration-resistant prostate cancer patients treated with androgen receptor pathway inhibitors. Reviewed International journal

    Asako Machidori, Masaki Shiota, Satoshi Kobayashi, Takashi Matsumoto, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Masatoshi Eto

    Urologic oncology   39 ( 6 )   365.e1-365.e7 - 365.e7   2021.6

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    BACKGROUND: This study investigated the prognostic significance of complete blood count data in castration-resistant prostate cancer patients treated using androgen receptor pathway inhibitors (ARPIs). PATIENTS AND METHODS: Patients treated with an ARPI, abiraterone or enzalutamide, as first-line therapy for castration-resistant prostate cancer from 2014 to 2018 were included. The association between complete blood count data and prognoses including progression-free survival and overall survival (OS) was investigated. RESULTS: High white blood cell counts (<median vs. ≥median; hazard ratio [HR], 1.82, 95% confidence interval [CI], 1.14-2.89; P = 0.012) and high neutrophil-to-lymphocyte ratios (<median vs. ≥median; HR, 1.90, 95% CI, 1.11-3.27; P = 0.020) were associated with a high risk of progression in univariate analysis. In univariate analysis, high hemoglobin (Hb) levels (<median vs. ≥median; HR, 0.41, 95% CI, 0.24-0.73; P = 0.0023) and high red cell distribution widths (<median vs. ≥median; HR, 2.41, 95% CI, 1.37-4.25; P = 0.0023) were associated with a low and a high risk of all-cause mortality, respectively. In multivariate analysis, high Hb levels (<median vs. ≥median; HR, 0.42, 95% CI, 0.22-0.79; P = 0.0076) were repeatedly associated with a low risk of all-cause mortality. CONCLUSION: We found that white blood cell counts and neutrophil-to-lymphocyte ratios may be prognostic for progression-free survival while red cell distribution widths may be prognostic for OS. In particular, a low Hb level was a robust prognostic factor for poor OS. These findings could be useful in predicting prognosis in CRPC patients treated with ARPIs.

    DOI: 10.1016/j.urolonc.2020.09.036

  • Clinical advantages of robot‐assisted partial nephrectomy versus laparoscopic partial nephrectomy in terms of global and split renal functions: A propensity score‐matched comparative analysis Reviewed International journal

    Satoshi Kobayashi, Jun Mutaguchi, Eiji Kashiwagi, Ario Takeuchi, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto

    International Journal of Urology   28 ( 6 )   630 - 636   2021.6

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    OBJECTIVES: To identify predictors of renal function preservation, and to compare the global and split renal function outcomes of robot-assisted partial nephrectomy and laparoscopic partial nephrectomy. METHODS: Demographic, operative and pathological data, as well as renal function outcomes, of 251 patients who underwent laparoscopic (n = 104) and robot-assisted (n = 147) partial nephrectomy between 2008 and 2018 were retrospectively analyzed. Propensity score matching (1:1) was carried out to adjust for potential baseline confounders. Functional outcomes were assessed based on the estimated glomerular filtration rate and dynamic renal scintigraphy (using 99m Tc-mercaptoacetyltriglycine), including renal volumetric analysis. RESULTS: A total of 98 patients were allocated to each partial nephrectomy group. Ischemic (laparoscopic vs robot-assisted partial nephrectomy: 29 vs 15 min, P < 0.001) and operative times (181 vs 100 min, P < 0.001) were shorter in robot-assisted partial nephrectomy. The preservation ratio of global renal function at 3 months (88.3% vs 91.4%, P = 0.040) and 12 months (87.8% vs 91.5%, P = 0.010) postoperatively, and the renal function of the operated kidney (80.3% vs 88.2%, P < 0.001) were greater after robot-assisted partial nephrectomy. In robot-assisted partial nephrectomy, the volume of resected parenchyma was significantly smaller (27.2 vs 15.5 mL, P < 0.001), resulting in greater postoperative normal parenchymal volumes (120 vs 132 mL, P < 0.001) and a greater parenchymal preservation ratio (81.1% vs 90.1%, P < 0.001). The parenchymal preservation ratio was the strongest predictor of renal function preservation after surgery (P < 0.001, odds ratio 6.02). CONCLUSIONS: Robot-assisted partial nephrectomy allows better preservation of split renal function than laparoscopic partial nephrectomy by increasing the parenchymal preservation ratio. This translates into better postoperative global renal function.

    DOI: 10.1111/iju.14525

  • Clinical advantages of robot-assisted partial nephrectomy versus laparoscopic partial nephrectomy in terms of global and split renal functions: A propensity score-matched comparative analysis Invited Reviewed International journal

    @Kobayashi S, @Mutaguchi J, @Kashiwagi E, @Takeuchi A, @Shiota M, @Inokuchi J, @Eto M.

    Int J Urol. 2021 Jun;28(6):630-636. doi: 10.1111/iju.14525. Epub 2021 Mar 3.   2021.6

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  • Prognostic significance of complete blood count parameters in castration-resistant prostate cancer patients treated with androgen receptor pathway inhibitors Invited Reviewed International journal

    @Machidori A, @Shiota M, @Kobayashi S, @Matsumoto T, @Monji K, @Kashiwagi E, @Takeuchi A, @Takahashi R, @Inokuchi J, @Eto M.

    Urol Oncol. 2021 Jun;39(6):365.e1-365.e7. doi: 10.1016/j.urolonc.2020.09.036. Epub 2020 Oct 17.   2021.6

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  • Urinary collecting system invasion on multiphasic CT in renal cell carcinomas: prevalence, characteristics, and clinical significance. Reviewed International journal

    Atsushi Takamatsu, Kotaro Yoshida, Masaru Obokata, Dai Inoue, Norihide Yoneda, Yoshifumi Kadono, Satoshi Kobayashi, Toshifumi Gabata

    Abdominal radiology (New York)   46 ( 5 )   2090 - 2096   2021.5

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    PURPOSE: The aim of this study was to determine the prevalence of collecting system invasion (CSI) on multiphasic CT, validate the pathological findings, and investigate the relationship between CSI and clinical outcomes in patients with renal cell carcinomas (RCC). METHODS: Patients pathologically diagnosed with RCC between January 2008 and December 2017 were retrospectively enrolled in this study. They were divided into two groups according to the presence of CSI on multiphasic CT images. Patients' clinical characteristics, radiological findings, and overall survival (OS) and recurrence-free survival (RFS) rates were analyzed and compared between the groups. In addition, the correlation of radiological findings with pathological findings was investigated. RESULTS: Among the included 347 kidneys of 340 patients, CSI was observed in 11 kidneys (3%; 95% confidence interval, 1.3-5.0%). In all the 11 kidneys, the tumors were pathologically diagnosed as clear cell RCC, and in one kidney, the tumor also had sarcomatoid features. When pathological CSI served as the standard of reference, the sensitivity, specificity, and accuracy of CSI on CT were 50%, 99.7%, and 97.1%, respectively. The OS and RFS rates were not significantly different between patients with CSI on CT and those without CSI. CONCLUSION: This study found that the prevalence of RCC-related CSI was 3%. Because of the low prevalence, we cannot exclude the possibility that CSI on CT would be associated with the OS and RFS. Further studies are needed to determine whether CSI on CT can be an independent prognostic factor for survival in patients with RCC.

    DOI: 10.1007/s00261-020-02859-y

  • Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy: a case report. Reviewed International journal

    Hiroki Kobayashi, Satoshi Kobayashi, Masaki Shiota, Dai Takamatsu, Tatsuro Abe, Eiji Kashiwagi, Ario Takeuchi, Junichi Inokuchi, Kenichi Kohashi, Yoshiyuki Shioyama, Yoshinao Oda, Masatoshi Eto

    International cancer conference journal   10 ( 2 )   96 - 99   2021.4

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    Salvage radical prostatectomy is a therapeutic option for the biochemical recurrence of prostate cancer after radiotherapy. However, only one case report of salvage radical prostatectomy after carbon ion radiotherapy has been reported. We report a case of salvage robot-assisted radical prostatectomy for local recurrence of prostate cancer after carbon ion radiotherapy with surgical video. Owing to adhesion and degeneration after radiotherapy, difficulties in surgery and post-operative complications have been anticipated. However, surgery was feasible without severe peri- and post-operative complications. Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy may be a reasonable therapeutic option. Supplementary Information: The online version contains supplementary material available at 10.1007/s13691-020-00464-w.

    DOI: 10.1007/s13691-020-00464-w

  • Efficacy and Safety of 4-Weekly Docetaxel for Castration-Resistant Prostate Cancer Invited Reviewed International journal

    @Yamashita T, @Shiota M, @Machidori A, @Kobayashi S, @Matsumoto T, @Monji K, @Kashiwagi E, @Takeuchi A, @Takahashi R, @Inokuchi J, @Shiga KI, @Yokomizo A, @Eto M.

    Cancer Invest. 2021 Mar;39(3):251-256. doi: 10.1080/07357907.2020.1871486. Epub 2021 Jan 14.   2021.3

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  • Efficacy and Safety of 4-Weekly Docetaxel for Castration-Resistant Prostate Cancer Reviewed International journal

    Takuya Yamashita, Masaki Shiota, Asako Machidori, Satoshi Kobayashi, Takashi Matsumoto, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Ken-ichiro Shiga, Akira Yokomizo, Masatoshi Eto

    Cancer Investigation   39 ( 3 )   251 - 256   2021.3

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    We investigated the efficacy and safety profiles of 4-weekly docetaxel for castration-resistant prostate cancer. Patients treated with ≥2 courses of docetaxel chemotherapy (median, 70 mg/m2) between 2008 and 2018 were included. Among 125 Japanese men, 40 (32.0%) and 85 (68.0%) were treated with 3-weekly and 4-weekly regimens, respectively. In the 4-weekly regimen, the risks of progression, treatment failure, and any-cause mortality were comparable to those in the 3-weekly regimen. The incidences of severe adverse events were also similar between the 3-weekly and 4-weekly regimens. These data suggest that the 4-weekly regimen may be an acceptable option for selected patients.

    DOI: 10.1080/07357907.2020.1871486

  • Examination of the Prefrontal Cortex Hemodynamic Responses to the Fist-Edge-Palm Task in Naïve Subjects Using Functional Near-Infrared Spectroscopy Invited Reviewed International journal

    @Kobayashi S, @Iwama Y, @Nishimaru H, @Matsumoto J, @Setogawa T, @Ono T, @Nishijo H.

    Front Hum Neurosci. 2021 Feb 5;15:617626. doi: 10.3389/fnhum.2021.617626. eCollection 2021.   2021.2

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  • Salvage robot-assisted radical prostatectomy after carbon ion radiotherapy: a case report Invited Reviewed International journal

    @Kobayashi H, @Kobayashi S, @Shiota M, @Takamatsu D, @Abe T, @Kashiwagi E, @Takeuchi A, @Inokuchi J, @Kohashi K, @Shioyama Y, @Oda Y, @Eto M.

    Int Cancer Conf J. 2021 Jan 3;10(2):96-99. doi: 10.1007/s13691-020-00464-w. eCollection 2021 Apr.   2021.1

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  • Surgical Navigation Improves Renal Parenchyma Volume Preservation in Robot-Assisted Partial Nephrectomy: A Propensity Score Matched Comparative Analysis Invited Reviewed International journal

    @Kobayashi S, @Cho B, @Mutaguchi J, @Inokuchi J, @Tatsugami K, @Hashizume M, @Eto M.

    J Urol. 2020 Jul;204(1):149-156. doi: 10.1097/JU.0000000000000709. Epub 2020 Dec 20.   2020.7

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  • Surgical Navigation Improves Renal Parenchyma Volume Preservation in Robot-Assisted Partial Nephrectomy: A Propensity Score Matched Comparative Analysis Reviewed International journal

    Satoshi Kobayashi, Byunghyun Cho, Jun Mutaguchi, Junichi Inokuchi, Katsunori Tatsugami, Makoto Hashizume, Masatoshi Eto

    Journal of Urology   204 ( 1 )   149 - 156   2020.7

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    PURPOSE: We investigated the relationship between the surgical navigation system and postoperative parenchyma preservation volume, and assessed the feasibility of image guided surgery in robot-assisted partial nephrectomy. MATERIALS AND METHODS: We developed surgical navigation with registration between real-time endoscopic images using 3-dimensional virtual reality models for robot-assisted partial nephrectomy. Surgical outcomes of 44 (nonsurgical navigation group) and 102 (surgical navigation group) patients between June 2013 and December 2018 were retrospectively analyzed. To adjust for potential baseline confounders propensity score matching (1:1) was performed. Renal parenchymal preservation rate and extraparenchymal volume with a tumor including functional and oncological outcomes ("trifecta" defined as warm ischemia time of less than 25 minutes, no complications and negative surgical margins; "pentafecta" defined as trifecta plus greater than 90% preservation of estimated glomerular filtration rate at 12 months postoperatively and chronic kidney disease up staging) were evaluated using volumetric analysis and compared. RESULTS: After matching, 42 patients were allocated to each group. No significant differences in baseline characteristics; complications; and intraoperative, trifecta and pentafecta outcomes were observed between the 2 groups. Pathological T stages were significantly different between the groups (T1a/T1b/T2a or more 25/10/7 in the nonsurgical navigation group vs 35/7/0 in the surgical navigation group, p=0.003). Extraparenchymal volumes and parenchyma volume preservation rates were significantly higher in the surgical navigation group (21.4 vs 17.2 ml, p=0.041 and 83.5% vs 90.0%, p=0.042, respectively). Surgical navigation was positively associated with improved parenchyma preservation volume (p=0.003). CONCLUSIONS: Surgical navigation preserves renal parenchyma in robot-assisted partial nephrectomy and may contribute to improvement in postoperative renal function.

    DOI: 10.1097/ju.0000000000000709

  • Reply by Authors. Reviewed International journal

    Satoshi Kobayashi, Byunghyun Cho, Jun Mutaguchi, Junichi Inokuchi, Katsunori Tatsugami, Makoto Hashizume, Masatoshi Eto

    The Journal of urology   204 ( 1 )   156 - 156   2020.7

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    DOI: 10.1097/JU.0000000000000709.02

  • Assessment of surgical skills by using surgical navigation in robot-assisted partial nephrectomy Reviewed International journal

    Satoshi Kobayashi, Byunghyun Cho, Arnaud Huaulm{'{e } }, Katsunori Tatsugami, Hiroshi Honda, Pierre Jannin, Makoto Hashizumea, Masatoshi Eto

    International Journal of Computer Assisted Radiology and Surgery   14 ( 8 )   1449 - 1459   2019.8

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    PURPOSE: To assess surgical skills in robot-assisted partial nephrectomy (RAPN) with and without surgical navigation (SN). METHODS: We employed an SN system that synchronizes the real-time endoscopic image with a virtual reality three-dimensional (3D) model for RAPN and evaluated the skills of two expert surgeons with regard to the identification and dissection of the renal artery (non-SN group, n = 21 [first surgeon n = 9, second surgeon n = 12]; SN group, n = 32 [first surgeon n = 11, second surgeon n = 21]). We converted all movements of the robotic forceps during RAPN into a dedicated vocabulary. Using RAPN videos, we classified all movements of the robotic forceps into direct action (defined as movements of the robotic forceps that directly affect tissues) and connected motion (defined as movements that link actions). In addition, we analyzed the frequency, duration, and occupancy rate of the connected motion. RESULTS: In the SN group, the R.E.N.A.L nephrometry score was lower (7 vs. 6, P = 0.019) and the time to identify and dissect the renal artery (16 vs. 9 min, P = 0.008) was significantly shorter. The connected motions of inefficient "insert," "pull," and "rotate" motions were significantly improved by SN. SN significantly improved the frequency, duration, and occupancy rate of connected motions of the right hand of the first surgeon and of both hands of the second surgeon. The improvements in connected motions were positively associated with SN for both surgeons. CONCLUSION: This is the first study to investigate SN for nephron-sparing surgery. SN with 3D models might help improve the connected motions of expert surgeons to ensure efficient RAPN.

    DOI: 10.1007/s11548-019-01980-8

  • [Significance of the antimicrobial drug used to prevent febrile infection following prostate needle biopsy]. Reviewed

    Satoshi Kobayashi, Tomoko Maki, Takeshi Kobayashi, Masumitsu Hamaguchi, Masahiro Yoshikawa, Naotaka Sakamoto, Atushi Iguchi

    Hinyokika kiyo. Acta urologica Japonica   60 ( 5 )   227 - 30   2014.5

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    The rate of incidence of febrile infection and the antimicrobial drug used at the time of prostate needle biopsy was examined retrospectively. SPFX (sparfloxacin) 400 mg (January 2007 to March 2010) and LVFX (levofloxacin) 500 mg (April 2010, onward) were administered prophylactically in 1,034 patients undergoing transrectal or transperineal prostate biopsy. One febrile infection occurred and resolved in each group. A single dose of LVFX 500 mg before the procedure effectively prevented febrile infection in both transrectal and transperineal prostate needle biopsy.

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Books

  • 手術ナビゲーションの進歩

    月野圭治, 小林聡, 牟田口淳, 猪口淳一, 江藤正俊(Role:Joint author)

    日本臨床  2024.2 

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    Advances in surgical navigation

  • 変わる医療-先端技術がもたらす新しい医療 手術ナビゲーションシステムがもたらす新しいロボット手術

    小林聡, 江藤正俊(Role:Sole author)

    映像情報Medical  2022.4 

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    Changing Medicine - New Medical Care Brought to You by Advanced Technology New Robotic Surgery Brought to You by Surgical Navigation Systems

  • 内視鏡手術におけるVR・ARの有用性

    小林 聡(Role:Sole author)

    臨床泌尿器  2021.9 

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    Usefulness of VR / AR in endoscopic surgery

  • 画像ナビゲーション手術の進歩

    小林 聡(Role:Sole author)

    日本臨床  2021.5 

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    Advances in image navigation surgery

  • 医療に活かす生体医工学

    小林 聡(Role:Joint author)

    2020.11 

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    Biomedical engineering for medical use

Presentations

  • Feasibility of Multi-Section Continuum Robotic Ureteroscope in the Kidney

    Satoshi Kobayashi, Franklin King, Masaki Fumitaro, Daniel A Wollin, Adam Stuar, Kibel Nobuhiko Hata, Masatoshi Eto

    Société Internationale d'Urologie  2023.10 

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    Feasibility of Multi-Section Continuum Robotic Ureteroscope in the Kidney

  • L43K超音波プローブアタッチメント開発における市販後調査

    小林聡, 中楯龍, 宮田信一, 月野圭治, 牟田口淳, 後藤駿介, 門司恵介, 塩田真己, 猪口淳一, 江藤正俊

    第32回日本コンピュータ外科学会大会  2023.12 

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    Post-marketing survey in the development of L43K ultrasound probe attachment

  • L43K超音波プローブ専用 アタッチメント. 医工連携特別企画:成功事例から学ぶ医工連携~JSER医工連携アワードプレゼン~ Invited

    小林聡

    第37回日本泌尿器内視鏡ロボティクス学会総会  2023.11 

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    Attachment for L43K ultrasound probe. Special project for medical-engineering collaboration: Learning about medical-engineering collaboration from successful cases ~ JSER Medical-Engineering Collaboration Award Presentation ~

  • RAPNナビゲーションにおける自動追尾用アタッチメントの開発

    月野圭治, 小林聡, 牟田口 淳, 松元 崇, 門司 恵介, 塩田 真己, 猪口 淳一, 沖 英次, 江藤 正俊

    第37回日本泌尿器内視鏡ロボティクス学会総会  2023.11 

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    Development of automatic tracking attachment for RAPN navigation

  • ロボット支援手術内視鏡画像から 3D 臓器モデル画像を出力する画像変換モデルの構築

    月野圭治, 宮内翔子, 小林 聡, 小栗 晋, 牟田口 淳, 塚原茂大, 後藤駿介, 松元 崇, 門司恵介, 塩田真己, 猪口淳一, 沖 英次, 倉爪 亮, 江藤正俊

    第32回日本コンピュータ外科学会大会  2023.12 

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    Construction of an image conversion model that outputs 3D organ model images from robot-assisted surgery endoscopic images

  • 尿管鏡支援ロボットの実現可能性に向けた開発研究

    小林聡, 正木文太郎, Franklin King, Daniel A Wollin, Adam Stuart Kibel, 波多信彦, 江藤正俊

    第37回日本泌尿器内視鏡ロボティクス学会総会  2023.11 

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    Research and development towards the feasibility of ureteroscopy-assisted robots

  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention.

    Kobayashi S

    36th International Congress Computer Assisted Radiology and Surgery.  2022.6 

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    Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention.

  • Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention

    Kobayashi S

    Radiology Research Symposium 2022  2022.5 

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    Automatic segmentation of prostate and extracapsular structures in MRI to predict needle deflection in percutaneous prostate intervention

  • da Vinci Surgical System Xiにおける3次元画像と光学式追跡システムを併用した自動追尾型手術 ナビゲーション開発 -ナビゲーションの標準化に向けて- Invited

    小林聡

    日本泌尿器内視鏡・ロボティクス学会  2021.11 

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    Development of automatic tracking surgical navigation using 3D images and an optical tracking system in the da Vinci Surgical System Xi -Toward standardization of navigation-

  • ナビゲーションシステムを用いたRAPNの実践

    小林聡

    日本泌尿器内視鏡・ロボティクス学会  2021.11 

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    Practice of RAPN using navigation system

  • マイクロマニピュレータを搭載したレゼクトスコープ

    中楯 龍, 牟田口淳, 小林 聡, 荒田純平, 大澤啓介, 長尾吉泰, 赤星朋比古, 江藤正俊

    第30回コンピュータ外科学会  2021.11 

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    Resectoscope with micromanipulator

  • RAPNにおけるナビゲーションシステムの有効性 -ナビゲーショ ンで手術はどう変化したのか- Invited

    小林聡

    第13回日本ロボット外科学会  2020.1 

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    Effectiveness of the navigation system in RAPN -How has navigation changed surgery-

  • RAPNにおける手術戦略:3D画像術中ナビゲーションの導入

    猪口淳一, 小林聡

    第34回日本泌尿器内視鏡学会総会  2020.11 

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    Surgical Strategy in RAPN: Introduction of 3D Imaging Intraoperative Navigation

  • The preservation of more normal renal parenchyma improves the operated renal function decreased by partial nephrectomy.

    Kobayashi S

    108th The Japanese Urological Association  2020.12 

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    The preservation of more normal renal parenchyma improves the operated renal function decreased by partial nephrectomy.

  • ロボット支援腎部分切除術における手術ナビゲーションは患側腎を温存する.

    牟田口淳, 小林聡

    第34回日本泌尿器内視鏡学会総会  2020.11 

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    Surgical navigation in robot-assisted partial nephrectomy preserves the affected kidney.

  • 当院におけるロボット手術におけるナビゲーション開発の動向 Invited

    小林聡

    第17回泌尿器再建再生研究会  2020.9 

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    Trends in navigation development in robotic surgery at our hospital

  • 膀胱内視鏡における画像支援に用いる人工知能アルゴリズム検討

    牟田口淳, 小林聡

    第108回日本泌尿器科学会総会  2020.12 

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    Investigation of artificial intelligence algorithm used for image support in cystoendoscopy

  • Assessment of surgical skills by using surgical navigation in robot-assisted partial nephrectomy.

    Kobayashi S

    33st International Congress and Exhibition of Computer Assisted Radiology and Surgery  2019.6 

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    Assessment of surgical skills by using surgical navigation in robot-assisted partial nephrectomy.

  • Development of next-generation surgical navigation system in Robot-assisted partial nephrectomy

    Kobayashi S

    第71回西日本泌尿器科学会総会  2019.11 

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    Development of next-generation surgical navigation system in Robot-assisted partial nephrectomy

  • Novel robotic navigation system Invited

    Kobayashi S

    The Hong Kong Congress of Endourology  2019.6 

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    Novel robotic navigation system

  • RAPNへの拡張現実 Augmented Reality手術ナビゲーションシステム開発

    小林聡

    第32回日本内視鏡外科学会総会  2019.12 

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    Augmented Reality to RAPN Augmented Reality Surgical Navigation System Development

  • Tri-Scan強調画像を用いたU-Netによる膀胱鏡画像からの腫瘍検出

    楳原愛子, 諸岡健一, 牟田口淳, 小林 聡, 宮内翔子, 倉爪亮, 江藤正俊

    日本コンピュータ外科学会誌  2019.11 

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    Tumor detection from cystoscopic images by U-Net using Tri-Scan-enhanced images

  • ロボット支援腎部分切除術 ~腎機能温存への工夫~

    小林聡

    第32回日本内視鏡外科学会総会  2019.12 

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    Robot-assisted partial nephrectomy ~Ingenuity for preserving renal function~

  • ロボット支援腎部分切除術における手術ナビゲーションは患側腎を温存する

    小林聡

    第29回九州内視鏡下手術手技研究会  2019.12 

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    Surgical navigation in robot-assisted partial nephrectomy preserves the affected kidney

  • ロボット支援腎部分切除術における手術ナビゲーションは患側腎を温存する

    小林聡

    第32回日本泌尿器内視鏡学会総会  2018.11 

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    Surgical navigation in robot-assisted partial nephrectomy preserves the affected kidney

  • ロボット支援腎部分切除術における自動追従型手術ナビゲーションの有効性についての検討

    小林聡

    第106回日本泌尿器科学会総会  2018.4 

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    Examination of the effectiveness of automatic tracking type surgical navigation in robot-assisted partial nephrectomy

  • 当院における腎門部腫瘍の工夫-RAPNにおける手術ナビゲーション- Invited

    小林聡

    第32回日本泌尿器内視鏡学会総会  2018.11 

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    Ingenuity of renal hilum tumor in our hospital - Surgical navigation in RAPN -

  • SURGICAL NAVIGATION USING INTUITIVE IMAGE-TO-PATIENT REGISTRATION FOR ROBOT-ASSISTED PARTIAL NEPHRECTOMY

    Kobayashi S

    15th Urological Association of Asia Congress  2017.8 

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    SURGICAL NAVIGATION USING INTUITIVE IMAGE-TO-PATIENT REGISTRATION FOR ROBOT-ASSISTED PARTIAL NEPHRECTOMY

  • Surgical Navigation using Intuitive Image-to-Patient Registration for Robot-Assisted Partial Nephrectomy: Clinical Feasibility study.

    Kobayashi S

    35th World Congress of Endourology  2017.11 

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    Surgical Navigation using Intuitive Image-to-Patient Registration for Robot-Assisted Partial Nephrectomy: Clinical Feasibility study.

  • Surgical navigation using intuitive image-to-patient registration for robot-assisted partial nephrectomy: clinical feasibility study

    Kobayashi S

    31st International Congress and Exhibition of Computer Assisted Radiology and Surgery  2017.9 

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    Surgical navigation using intuitive image-to-patient registration for robot-assisted partial nephrectomy: clinical feasibility study

  • ナビゲーションによるRAPN適応拡大 Invited

    小林聡

    第31回日本泌尿器内視鏡学会総会  2017.11 

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    Expanding RAPN indications through navigation

  • 九州大学におけるロボット手術ナビゲーション開発と臨床応用.

    小林聡

    第27回九州内視鏡下外科手術研究会  2017.9 

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    Robotic Surgical Navigation Development and Clinical Application at Kyushu University

  • 九州大学におけるロボット手術ナビゲーション開発への挑戦

    小林聡

    第9回日本ロボット外科学会学術集会  2017.1 

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    Challenge to develop robotic surgical navigation at Kyushu University

  • 自動追従型手術ナビゲーションシステムのロボット支援腎部分切除術への応用と今後の展望

    小林聡

    第105回日本泌尿器科学会総会  2017.4 

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    Application of automatic tracking type surgical navigation system to robot-assisted partial nephrectomy and future prospects

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MISC

  • "特集 今こそ知りたい!ロボット時代の腹腔鏡手術トレーニング -腹腔鏡技術認定を目指す泌尿器科医のために<特別付録Web動画>  <腹腔鏡手術トレーニングにおける技術の活用>  内視鏡手術におけるVR・ARの有用性." Reviewed

    @小林聡、@猪口淳一、@江藤正俊:

    臨床泌尿器科 75 (10): 752-756, 2021   2021.9

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  • Editorial Comment to Endoscopic laser treatment for urine leakage caused by an isolated calyx after robot-assisted partial nephrectomy Reviewed

    @Kobayashi S, @Shiota M.

    IJU Case Rep. 2021 Sep 12;4(6):346. doi: 10.1002/iju5.12349. eCollection 2021 Nov.   2021.9

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  • RAPNにおける術中ナビゲーションの現状と今後の展望. Reviewed

    @猪口淳一、@小林 聡、@牟田口 淳、@江藤正俊:

    泌尿器科 13 (3): 356-362, 2021   2021.3

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  • Reply by Authors Reviewed

    @Kobayashi S, @Cho B, @Mutaguchi J, @Inokuchi J, @Tatsugami K, @Hashizume M, @Eto M.

    J Urol. 2020 Jul;204(1):156. doi: 10.1097/JU.0000000000000709.02. Epub 2020 Apr 23.   2020.7

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Professional Memberships

  • Japanese Society for Medical and Biological Engineering

  • Japan Robotic Surgery Society

  • Japan Society of Urologic Oncology

  • International Journal of Clinical Oncology

  • Japanese. Society of Endourology and Robotics

  • The Japanese Urological Association

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Academic Activities

  • 座長

    第111回日本泌尿器科学会総会  ( Japan ) 2024.4 - 2024.5

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    Type:Competition, symposium, etc. 

    Number of participants:10

  • 西日本泌尿器科学会

    2023.4 - 2028.5

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    Type:Academic society, research group, etc. 

Research Projects

  • 腎癌患者における遠隔支援を目指した包括的な AI 画像支援システム開発に関する研究.

    2024 - 2025

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 腎癌診療におけるハイブリットAI画像支援技術の開発研究

    Grant number:23K19219  2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity start-up

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 腎癌患者における遠隔支援を目指した包括的な AI 画像支援システム開発に関する研究

    Grant number:2024-04-025  2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 腎癌診療における遠隔医療に向けたハイブリットAI画像支援技術のクラウドマイグレーション開発研究

    2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • AIによる自動registration機能を搭載した新しいRAPNナビゲーションシステムの開発

    2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 腎機能温存を目的とした腎癌診療におけるハイブリットAI画像支援技術の開発研究

    2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 腎癌診療におけるハイブリットAI画像支援技術の開発研究

    Grant number:23K19219  2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

  • 腎癌診療における腎機能温存を主軸としたハイブリットAI画像支援技術の開発研究

    2023 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 腎癌診療におけるハイブリットAI画像支援技術の開発研究

    2023 - 2024

    Japan Society for the Promotion of Science  研究活動スタート支援

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    Grant type:Joint research

  • 腎癌診療における遠隔医療に向けたハイブリットAI画像支援技術のクラウドマイグレーション開発研究

    2023 - 2024

    西川医療振興財団助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 腎機能温存を目的とした腎癌診療におけるハイブリットAI画像支援技術の開発研究

    2023 - 2024

    臨床研究奨励基金 助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 腎癌診療における腎機能温存を主軸としたハイブリットAI画像支援技術の開発研究

    2023 - 2024

    鈴木謙三記念医科学応用研究財団助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 手術ナビゲーション開発に関する研究.

    2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 手術用支援ロボット da Vinci Xi における拡張現実(Augmented Reality)と仮想現実(Virtual Reality)を 融合した次世代型手術ナビゲーション開発とロボット支援腎部分切除術への導入

    2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • da Vinci Surgical System Xiにおける3次元画像と光学式追跡システムを併用した自動追尾型手術ナビゲーション開発-ナビゲーションの標準化に向けて

    2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ロボット支援腎部分切除術に向けた腹部CT画像における深層学習による腎癌画像診断システムと3D腎癌画像構築システム開発

    2020 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ロボット支援腎部分切除におけるAR手術ナビゲーション開発・臨床導入

    Grant number:19K20713  2019 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

  • Surgical Navigation using Intuitive Image-to-Patient Registration for Robot-Assisted Partial Nephrectomy: Clinical Feasibility study

    2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ロボット支援腎部分切除術における手術ナビゲーションの臨床応用と検討

    2016 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Educational Activities

  • 泌尿器科学

Media Coverage

  • 泌尿器科の最先端技術の紹介 Newspaper, magazine

    2024年福岡の頼れるお医者さん  2024.1

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    泌尿器科の最先端技術の紹介

Travel Abroad

  • 2021.4 - 2023.3

    Staying countory name 1:United States   Staying institution name 1:Harvard Medical School

    Staying institution name 2:Brigham and Women's Hospital