Updated on 2024/11/27

Information

 

写真a

 
OKITA AYAKO
 
Organization
Kyushu University Hospital Ophthalmology Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
External link

Degree

  • Medical doctor(Kyushu University, Japan)

Research Interests・Research Keywords

  • Research theme:Oxidative DNA damage is one of the causes of retinal ganglion cell death in the normal tension glaucoma

    Keyword:Oxidative stress, DNA, Glaucoma

    Research period: 2017.4

Papers

  • Comparison of Microperimetry and Static Perimetry for Evaluating Macular Function and Progression in Retinitis Pigmentosa

    Fukushima, M; Tao, Y; Shimokawa, S; Zhao, HY; Shimokawa, S; Funatsu, J; Hisai, T; Okita, A; Fujiwara, K; Hisatomi, T; Takeda, A; Ikeda, Y; Sonoda, KH; Murakami, Y

    OPHTHALMOLOGY SCIENCE   4 ( 6 )   100582   2024.12   ISSN:2666-9145

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    Language:English   Publisher:Ophthalmology Science  

    Purpose: To compare the usefulness of microperimetry and static automated perimetry in patients with retinitis pigmentosa (RP), using macular anatomical metrics as a reference. Design: Prospective observational study. Participants: Forty-eight eyes of 48 patients with RP in Kyushu University Hospital who underwent microperimetry-3 (MP-3) and Humphrey Field Analyzer (HFA) 10-2 testing ≥3 times during ≥2 years were included. Methods: Macular anatomy (ellipsoid zone [EZ] length) was assessed by OCT, and macular function was assessed by MP-3 (mean retinal sensitivity at radii 2°, 4°, and 8°) and HFA10-2 program (mean retinal sensitivity at radii 2°, 4°, and 8°). Correlations between functional and anatomical parameters were analyzed cross sectionally at baseline and longitudinally by comparing the rate of progression. Main Outcome Measures: Correlation coefficients between anatomical and functional metrics. Results: The mean age at baseline was 50.1 ± 12.3 years, and the mean follow-up period was 2.8 ± 0.7 years. At baseline, EZ length was significantly correlated with MP-3 mean retinal sensitivity at radii 2°, 4°, and 8° (Spearman's ρ = 0.65, 0.84, 0.89; all P < 0.005) and HFA10-2 mean retinal sensitivity at radii 2°, 4°, and 8° (Spearman's ρ = 0.61, 0.73, 0.78; all P < 0.005). Longitudinal analysis showed that the slope of EZ length (−88.92 μm/year) was significantly correlated with the slope of MP-3 retinal sensitivity at 8° radius (−0.62 decibels [dB]/year; Spearman's ρ = 0.31, P=0.03) and the slope of HFA retinal sensitivity at 8° radius (−0.60 dB/year; Spearman's ρ = 0.43, P < 0.005). Conclusions: Both MP-3 and HFA values were cross sectionally well-correlated with EZ length in patients with patients; however, these associations became weaker in the longitudinal analysis. This highlights the need for researchers to explore additional or more sensitive parameters to better monitor RP progression. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

    DOI: 10.1016/j.xops.2024.100582

    Web of Science

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    PubMed

  • Ocular and Serum Profiles of Inflammatory Molecules Associated With Retinitis Pigmentosa

    Tao, Y; Fukushima, M; Shimokawa, S; Zhao, HY; Okita, A; Fujiwara, K; Takeda, A; Mukai, S; Sonoda, KH; Murakami, Y

    TRANSLATIONAL VISION SCIENCE & TECHNOLOGY   13 ( 8 )   18   2024.8   ISSN:2164-2591

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    Language:English   Publisher:Translational Vision Science and Technology  

    Purpose: To investigate the profiles and correlations between local and systemic inflammatory molecules in patients with retinitis pigmentosa (RP). Methods: The paired samples of aqueous humor and serum were collected from 36 eyes of 36 typical patients with RP and 25 eyes of age-matched patients with cataracts. The concentration of cytokines/chemokines was evaluated by a multiplexed immunoarray (Q-Plex). The correlations between ocular and serum inflammatory molecules and their association with visual function were analyzed. Results: The aqueous levels of IL-6, Eotaxin, GROα, I-309, IL-8, IP-10, MCP-1, MCP-2, RANTES, and TARC were significantly elevated in patients with RP compared to controls (all P < 0.05). The detection rate of aqueous IL-23 was higher in patients with RP (27.8%) compared with controls (0%). In patients with RP, Spearman correlation test demon-strated positive correlations for IL-23, I-309, IL-8, and RANTES between aqueous and serum expression levels (IL-23: ρ = 0.8604, P < 0.0001; I-309: ρ = 0.4172, P = 0.0113; IL-8: ρ = 0.3325, P = 0.0476; RANTES: ρ = 0.6685, P < 0.0001). In addition, higher aqueous IL-23 was associated with faster visual acuity loss in 10 patients with RP with detected aqueous IL-23 (ρ = 0.4119 and P = 0.0264). Multiple factor analysis confirmed that aqueous and serum IL-23 were associated with visual acuity loss in patients with RP. Conclusions: These findings suggest that ocular and systemic inflammatory responses have a close interaction in patients with RP. Further longitudinal studies with larger cohorts are needed to explore the correlation between specific inflammatory pathways and the progression of RP. Translational Relevance: This study demonstrates the local–systemic interaction of immune responses in patients with RP.

    DOI: 10.1167/tvst.13.8.18

    Web of Science

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    PubMed

  • Ocular and systemic profiles of inflammatory molecules associated with retinitis pigmentosa

    Tao, Y; Murakami, Y; Fukushima, M; Shimokawa, S; Zhao, HY; Okita, A; Fujiwara, K; Takeda, A; Sonoda, KH

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   64 ( 8 )   2023.6   ISSN:0146-0404 eISSN:1552-5783

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  • Circulating inflammatory monocytes oppose microglia and contribute to cone cell death in retinitis pigmentosa

    Funatsu, J; Murakami, Y; Shimokawa, S; Nakatake, S; Fujiwara, K; Okita, A; Fukushima, M; Shibata, K; Yoshida, N; Koyanagi, Y; Akiyama, M; Notomi, S; Nakao, S; Hisatomi, T; Takeda, A; Paschalis, EI; Vavvas, DG; Ikeda, Y; Sonoda, KH

    PNAS NEXUS   1 ( 1 )   2022.3   eISSN:2752-6542

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    Language:English   Publisher:PNAS Nexus  

    Retinitis pigmentosa (RP) is an intractable inherited disease that primarily affects the rods through gene mutations followed by secondary cone degeneration. This cone-related dysfunction can lead to impairment of daily life activities, and ultimately blindness in patients with RP. Paradoxically, microglial neuroinflammation contributes to both protection against and progression of RP, but it is unclear which population(s)— tissue-resident microglia and/or peripheral monocyte-derived macrophages (mϕ)— are implicated in the progression of the disease. Here, we show that circulating blood inflammatory monocytes (IMo) are key effector cells that mediate cone cell death in RP. Attenuation of IMo and peripherally engrafted mϕ by Ccl2 deficiency or immune modulation via intravenous nanoparticle treatment suppressed cone cell death in rd10 mice, an animal model of RP. In contrast, the depletion of resident microglia by a colony-stimulating factor 1 receptor inhibitor exacerbated cone cell death in the same model. In human patients with RP, IMo was increased and correlated with disease progression. These results suggest that peripheral IMo is a potential target to delay cone cell death and prevent blindness in RP.

    DOI: 10.1093/pnasnexus/pgac003

    Web of Science

    Scopus

    PubMed

Presentations

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Ophthalmology

Clinician qualification

  • Specialist

    Japanese Ophthalmological Society(JOS)

  • Specialist

    日本緑内障学会

Year of medical license acquisition

  • 2010