2025/06/15 更新

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写真a

フジワラ コウタ
藤原 康太
FUJIWARA KOHTA
所属
九州大学病院 眼科 助教
医学部 医学科(併任)
職名
助教
連絡先
メールアドレス
電話番号
0926425648
外部リンク

学位

  • 博士

研究テーマ・研究キーワード

  • 研究テーマ: 前視野緑内障の予防法構築に向けた疫学エビデンスの確立

    研究キーワード: 眼科疫学、緑内障

    研究期間: 2021年4月 - 2023年3月

受賞

  • 日本眼科学会学術奨励賞

    2020年4月  

論文

  • Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study

    Fujiwara, K; Ueda, E; Hata, J; Nakano, S; Hashimoto, S; Nakamura, S; Murakami, Y; Kubota, T; Yoshitomi, T; Ninomiya, T; Sonoda, KH

    BRITISH JOURNAL OF OPHTHALMOLOGY   108 ( 9 )   1204 - 1209   2024年9月   ISSN:0007-1161 eISSN:1468-2079

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    記述言語:英語   出版者・発行元:British Journal of Ophthalmology  

    Aims To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. Methods We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of corneal hysteresis, which had been measured with an ocular response analyzer. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. We conducted a logistic regression analysis to determine the ORs and their 95% CIs for the presence of outcomes according to the corneal hysteresis quartiles. Results Glaucoma was diagnosed in 154 participants: primary open-angle glaucoma (POAG), n=115; primary angle-closure glaucoma, n=17; exfoliation glaucoma, n=21 and secondary glaucoma without exfoliation glaucoma, n=1. After adjustment for confounders, the OR for prevalent glaucoma was significantly increased in the participants in the first corneal-hysteresis quartile compared with those in the fourth quartile (OR: 1.80; 95% CI: 1.03 to 3.17). Regarding glaucoma subtypes, the first-quartile participants had significantly greater likelihoods of the presence of POAG (OR: 1.63; 95% CI: 1.02 to 2.61) and exfoliation glaucoma (OR: 6.49; 95% CI: 1.44 to 29.30) compared with those in the third and fourth quartiles after adjustment for potential confounders. Conclusions These results demonstrated a significant inverse association between corneal hysteresis and the likelihood of glaucoma, suggesting that the measurement of corneal hysteresis would provide useful information for elucidating the aetiology of glaucoma.

    DOI: 10.1136/bjo-2023-323987

    Web of Science

    Scopus

    PubMed

  • Baseline Visual Function and Inflammatory Markers in the RP PRIMARY Study

    Hisai, T; Shimokawa, S; Fukushima, M; Fujiwara, K; Hirata, A; Takada, A; Kobayakawa, Y; Mawatari, G; Ishizu, M; Kaida, T; Miyata, K; Ikeda, Y; Sonoda, KH; Murakami, Y

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   65 ( 7 )   2024年6月   ISSN:0146-0404 eISSN:1552-5783

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  • Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study

    Nakamura, S; Ueda, E; Ohara, T; Hata, J; Honda, T; Fujiwara, K; Furuta, Y; Shibata, M; Hashimoto, S; Nakazawa, T; Nakao, T; Kitazono, T; Sonoda, KH; Ninomiya, T

    SCIENTIFIC REPORTS   14 ( 1 )   12017   2024年5月   ISSN:2045-2322

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    記述言語:英語   出版者・発行元:Scientific Reports  

    We investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007–2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the risk of dementia by the presence of retinopathy. During the follow-up period, 374 participants developed all-cause dementia. The cumulative incidence of dementia was significantly higher in those with retinopathy than those without (p < 0.05). Individuals with retinopathy had significantly higher risk of developing dementia than those without after adjustment for potential confounding factors (HR 1.64, 95% CI 1.19–2.25). Regarding the components of retinopathy, the presence of microaneurysms was significantly associated with a higher multivariable-adjusted HR for incident dementia (HR 1.94, 95% CI 1.37–2.74). Our findings suggest that, in addition to systemic risk factors, retinal microvascular signs from fundus photography provide valuable information for estimating the risk of developing dementia.

    DOI: 10.1038/s41598-024-62688-7

    Web of Science

    Scopus

    PubMed

  • Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population: The Hisayama Study

    Ueda, E; Yasuda, M; Fujiwara, K; Hashimoto, S; Honda, T; Nakamura, S; Hata, J; Ninomiya, T; Sonoda, KH

    OPHTHALMOLOGY SCIENCE   3 ( 4 )   100350   2023年12月   ISSN:2666-9145

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    記述言語:英語   出版者・発行元:Ophthalmology Science  

    Purpose: To examine the association between choroidal thickness and myopic maculopathy in a general Japanese population. Design: Population-based cross-sectional study. Participants: A total of 2841 residents of a Japanese community aged ≥ 40 years, who consented to participate and had available data of choroidal thickness and fundus photographs, were enrolled in this study. Methods: The choroidal thickness was measured by swept-source OCT. Participants were divided into quartiles of choroidal thickness. Myopic maculopathy was defined according to the classification system of the Meta-analysis of Pathologic Myopia Study Group. Main outcome measures were odds ratios (ORs) of choroidal thickness for prevalent myopic maculopathy. The ORs and 95% confidence intervals (CIs) were estimated using a logistic regression model. Main Outcome Measures: Prevalent myopic maculopathy. Results: Eighty-one participants had myopic maculopathy (45 diffuse chorioretinal atrophy, 31 patchy chorioretinal atrophy, and 5 macular atrophy). Individuals in the lowest quartile of choroidal thickness had a significantly greater OR for the presence of myopic maculopathy than those in the highest quartile of choroidal thickness (OR: 4.78 [95% CI: 1.78–16.72]) after adjusting for confounders, including axial length. The sensitivity analysis among the 1176 myopic individuals with axial length of ≥ 24.0 mm also showed that thinner choroidal thickness was significantly associated with prevalent myopic maculopathy. Conclusions: The present study demonstrated the significant inverse association between choroidal thickness and the likelihood of myopic maculopathy, suggesting that the measurement of choroidal thickness in addition to axial length would be useful for assessing the risk of myopic maculopathy and elucidating its pathogenesis. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

    DOI: 10.1016/j.xops.2023.100350

    Web of Science

    Scopus

    PubMed

  • Comparison of Microperimetry and Static Perimetry for Evaluating Macular Function and Disease Progression in Retinitis Pigmentosa

    Fukushima, M; Murakami, Y; Tao, Y; Shimokawa, S; Zhao, H; Shimokawa, S; Funatsu, J; Fujiwara, K; Takeda, A; Ikeda, Y; Sonoda, KH

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   64 ( 8 )   2023年6月   ISSN:0146-0404 eISSN:1552-5783

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  • Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study 査読 国際誌

    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Nakamura S, Hirakawa Y, Higashioka M, Hata J, Ninomiya T, Sonoda KH.

    Graefes Arch Clin Exp Ophthalmol   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Prevalence of Glaucoma and Its Systemic Risk Factors in a General Japanese Population: The Hisayama Study. 査読 国際誌

    Fujiwara K, Yasuda M, Hata J, Nakano S, Hashimoto S, Ueda E, Nakamura S, Murakami Y, Nakamuro T, Iwase A, Araie M, Tawara A, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH.

    Transl Vis Sci Technol   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Likely pathogenic structural variants in genetically unsolved patients with retinitis pigmentosa revealed by long-read sequencing 招待 査読 国際誌

    Sano Y, Koyanagi Y, Wong JH, Murakami Y, Fujiwara K, Endo M, Aoi T, Hashimoto K, Nakazawa T, Wada Y, Ueno S, Gao D, Murakami A, Hotta Y, Ikeda Y, Nishiguchi KM, Momozawa Y, Sonoda KH, Akiyama M, Fujimoto A.

    J Med Genet   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Prevalence of glaucoma and its systemic risk factors in a general Japanese population: The Hisayama Study. 招待 査読 国際誌

    Fujiwara K, Yasuda M, Hata J, Nakano S, Hashimoto S, Ueda E, Nakamura S, Murakami Y, Nakamuro T, Araie M, Tawara A, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH; Transl Vis Sci Technol.

    Transl Vis Sci Technol   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance. 招待 査読 国際誌

    Shirane M, Yawata N, Motooka D, Shibata K, Khor SS, Omae Y, Kaburaki T, Yanai R, Mashimo H, Yamana S, Ito T, Hayashida A, Mori Y, Numata A, Murakami Y, Fujiwara K, Ohguro N, Hosogai M, Akiyama M, Hasegawa E, Paley M, Takeda A, Maenaka K, Akashi K, Yokoyama WM, Tokunaga K, Yawata M, Sonoda KH.

    Front Immunol   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Association between body mass index and diabetic retinopathy in Asians: the Asian Eye Epidemiology Consortium (AEEC) study 招待 査読 国際誌

    Sabanayagam C, Sultana R, Banu R, Rim T, Tham YC, Mohan S, Chee ML, Wang YX, Nangia V, Fujiwara K, Tai ES, Song SJ, Bikbov MM, Raman R, Cheng CY, Wong TY, Jonas JB.

    Br J Ophthalmol   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Association between body mass index and diabetic retinopathy in Asians: the Asian Eye Epidemiology Consortium (AEEC) study

    Sabanayagam, C; Sultana, R; Banu, R; Rim, T; Tham, YC; Mohan, S; Li Chee, M; Wang, YX; Nangia, V; Fujiwara, K; Tai, ES; Song, SJ; Bikbov, MM; Raman, R; Cheng, CY; Wong, TY; Jonas, JB

    BRITISH JOURNAL OF OPHTHALMOLOGY   106 ( 7 )   980 - 986   2022年7月   ISSN:0007-1161 eISSN:1468-2079

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    記述言語:英語   出版者・発行元:British Journal of Ophthalmology  

    Background/aims Obesity is a well-known risk factor for diabetes, but its association with diabetic retinopathy (DR) is inconclusive, in particular in Asians. We aimed to assess whether body mass index (BMI) is associated with the presence and severity of DR in Asian populations with diabetes. Methods Pooled analysis of individual-level cross-sectional data from 10 010 adults with diabetes who participated in 12 population-based studies conducted in China, India, Japan, Russia (Asian), Singapore and South Korea that were part of the Asian Eye Epidemiology Consortium (AEEC). BMI was calculated as weight in kilograms divided by height in square metres and categorised into normal (<25 kg/m 2, reference), overweight (25-29.9 kg/m 2) and obese (≥30 kg/m 2). Any-DR (n=1669) and vision-threatening DR (VTDR, n=489) were assessed from digital retinal photographs and graded according to standard protocols. Each study was analysed separately using multivariable logistic regression models adjusted for age, sex, haemoglobin A1c%, systolic blood pressure and diabetes duration, and the estimated odds ratios (ORs) and 95% confidence interval (CIs) from all studies were then combined using random-effects models. Results In multivariable models, obesity showed a significant inverse association with any-DR (pooled OR (95% CI) =0.74 (0.59 to 0.91)) and VTDR (0.75 (0.60 to 0.93)). Similarly, in continuous analysis, BMI showed a significant inverse association with both any-DR (0.93 (0.87 to 0.99)) and VTDR (0.79 (0.68 to 0.92) per SD increase). Overweight did not show a significant association with any-DR. Conclusions Among Asian adults with diabetes, both BMI and obesity showed an inverse association with DR. These findings warrant confirmation in further longitudinal studies.

    DOI: 10.1136/bjophthalmol-2020-318208

    Web of Science

    Scopus

    PubMed

  • Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population

    Ueda, E; Hirabayashi, N; Ohara, T; Hata, J; Honda, T; Fujiwara, K; Furuta, Y; Shibata, M; Hashimoto, S; Nakamura, S; Nakazawa, T; Nakao, T; Kitazono, T; Ninomiya, T; Sonoda, KH

    OPHTHALMOLOGY SCIENCE   2 ( 2 )   100157   2022年6月   ISSN:2666-9145

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    記述言語:英語   出版者・発行元:Ophthalmology Science  

    Purpose: To assess the association of inner retinal thickness with prevalent dementia and regional brain atrophy in a general older population of Japanese. Design: Population-based, cross-sectional study. Participants: A total of 1078 residents aged 65 years or older who participated in an eye examination, a comprehensive survey of dementia, and brain magnetic resonance imaging scanning in 2017. Methods: The thicknesses of the inner retinal layers, namely, the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL)—were measured by swept-source OCT (SS-OCT). The association of these retinal thicknesses with the risk of the presence of dementia was estimated using restricted cubic splines and logistic regression models. Regional brain volumes were estimated separately by applying 2 different methods: voxel-based morphometry (VBM) and analysis by FreeSurfer software. The associations of GC-IPL and RNFL thickness with each brain regional volume were analyzed using multiple regression analysis. Main Outcome Measure: Prevalent dementia and regional brain atrophy. Results: Among the study participants, 61 participants (5.7%) were diagnosed with dementia. The likelihood of the presence of dementia significantly increased with lower GC-IPL thickness after adjusting for potential confounders (odds ratio, 1.62 [95% confidence interval, 1.30–2.01] per 1 standard deviation decrement in the GC-IPL thickness), but no significant association was observed with RNFL thickness. In the VBM analyses with the multivariable adjustment, lower GC-IPL thickness was significantly associated with lower volume of known brain regions related to cognitive functions (i.e., the hippocampus, amygdala, entorhinal area, and parahippocampal gyrus) and visual functions (i.e., the cuneus, lingual gyrus, and thalamus). Meanwhile, the volume of the thalamus significantly decreased with lower RNFL thickness, but none of the brain regions related to cognitive function exhibited a volume change in association with RNFL thickness. The sensitivity analysis using FreeSurfer analysis also showed that lower GC-IPL thickness was significantly associated with lower regional brain volume/intracranial volume of the hippocampus, amygdala, cuneus, lingual gyrus, and thalamus. Conclusions: Our findings suggest that the measurement of GC-IPL thickness by SS-OCT, which is a noninvasive, convenient, and reproducible method, might be useful for identifying high-risk individuals with dementia.

    DOI: 10.1016/j.xops.2022.100157

    Web of Science

    Scopus

    PubMed

  • Long-term Outcomes of Cataract Surgery in Patients with Retinitis Pigmentosa 招待 査読 国際誌

    Nakamura S, Fujiwara K, Yoshida N, Murakami Y, Shimokawa S, Koyanagi Y, Ikeda Y, Sonoda KH.

    Ophthalmol Retina   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population: The Hisayama Study. 招待 査読 国際誌

    Ueda E, Hirabayashi N, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakamura S, Nakazawa T, Nakao T, Kitazono T, Ninomiya T, Sonoda KH.

    Ophthalmol Sci   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Circulating inflammatory monocytes oppose microglia and contribute to cone cell death in retinitis pigmentosa. 招待 査読 国際誌

    Funatsu J, Murakami Y, Shimokawa S, Nakatake S, Fujiwara K, Okita A, Fukushima M, Shibata K, Yoshida N, Koyanagi Y, Akiyama M, Notomi S, Nakao S, Hisatomi T, Takeda A, Paschalis EI, Vavvas DG, Ikeda Y, Sonoda KH.

    PNAS Nexus   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Recurrence rate of cystoid macular edema with topical dorzolamide treatment and its risk factors in retinitis pigmentosa 招待 査読 国際誌

    Shimokawa S, Murakami Y, Fujiwara K, Funatsu J, Nakatake S, Koyanagi Y, Akiyama M, Yoshida N, Takeda A, Ikeda Y, Sonoda KH.

    Retina   2022年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Genotype and Long-term Clinical Course of Bietti Crystalline Dystrophy in Korean and Japanese Patients 招待 査読 国際誌

    Murakami Y, Koyanagi Y, Fukushima M, Yoshimura M, Fujiwara K, Akiyama M, Momozawa Y, Ueno S, Terasaki H, Oishi A, Miyata M, Ikeda H, Tsujikawa A, Mizobuchi K, Hayashi T, Fujinami K, Tsunoda K, Park JY, Han J, Kim M, Lee CS, Kim SJ, Park TK, Joo K, Woo SJ, Ikeda Y, Sonoda KH.

    Ophthalmol Retina   2021年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Risk factors for myopia at 1-year corrected age following laser photocoagulation for retinopathy of prematurity 招待 査読 国際誌

    Mori Y, Arima M, Ueda E, Fujiwara K, Seki E, Nakama T, Tsukamoto S, Akiyama M, Sonoda KH.

    Eye (Lond)   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes 招待 査読 国際誌

    Arima M, Nakao S, Kaizu Y, Wada I, Yamaguchi M, Fujiwara K, Akiyama M, Stitt AW, Sonoda KH.

    Sci Rep   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物

  • 緑内障疫学調査

    藤原康太

    2022年4月 

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    記述言語:日本語  

講演・口頭発表等

  • 網膜色素変性の黄斑機能進行評価におけるMP-3とHFAの比較

    福嶋正俊、村上祐介、陶妍、下川翔太郎、藤原康太、園田康平

    日本網膜硝子体学会総会  2022年12月 

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    開催年月日: 2022年12月

    記述言語:日本語  

    国名:日本国  

  • Long-term Outcomes of Cataract Surgery in Patients with Retinitis Pigmentosa

    Nakamura S, Fujiwara K, Yoshida N, Murakami Y, Shimokawa S, Koyanagi Y, Ikeda Y, Sonoda KH

    The 15th Joint Meeting of Chinese-Japanese-Korean Ophthalmologists  2022年9月 

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    開催年月日: 2022年9月

    記述言語:日本語  

    国名:日本国  

  • Comparison of MP-3 and HFA for evaluating macular function in patients with retinitis pigmentosa

    Fukushima M, Murakami Y, Tao Yan, Shimokawa S, Fujiwara K, Sonoda KH

    The 15th Joint Meeting of Chinese-Japanese-Korean Ophthalmologists  2022年9月 

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    開催年月日: 2022年9月

    記述言語:日本語  

    国名:日本国  

  • 近視と緑内障の関連:久山町研究

    上田瑛美, 安田美穂, 藤原康太, 橋本左和子, 中村駿, 園田康平

    日本近視学会  2022年5月 

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    開催年月日: 2022年5月

    記述言語:日本語  

    国名:日本国  

  • 原発開放隅角緑内障に対する白内障手術併用iStent inject W®挿入術の術後成績

    筒井紘樹, 村上祐介, 中武俊二, 藤原康太

    九州眼科学会  2022年5月 

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    開催年月日: 2022年5月

    記述言語:日本語  

    国名:日本国  

MISC

  • 久山町研究における緑内障疫学調査の実際. 臨床眼科

    藤原 康太, 中野 聡子, 園田 康平

    2022年4月

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

  • 耐糖能異常と乳頭周囲網膜神経線維層厚の関連 査読

    藤原康太

    2021年4月

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    記述言語:日本語   掲載種別:記事・総説・解説・論説等(学術雑誌)  

所属学協会

  • 日本眼科学会

  • 日本緑内障学会

  • 日本網膜硝子体学会

共同研究・競争的資金等の研究課題

  • 失明回避を目指す開放隅角緑内障の遺伝的リスク予測に関する研究開発

    2023年5月

  • 前向きコホート研究に基づいたOCT緑内障発症リスク予測モデルの開発

    研究課題/領域番号:23K09060  2023年 - 2025年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    担当区分:研究代表者  資金種別:科研費

  • 前向きコホート研究に基づいたOCT緑内障発症リスク予測モデルの開発

    2023年 - 2025年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    資金種別:科研費

  • 前視野緑内障の予防法構築に向けた疫学エビデンスの確立:久山町研究

    2021年 - 2022年

    日本学術振興会  科学研究費助成事業  若手研究

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    資金種別:科研費

  • 緑内障発症・進行リスクスコアの確立と個別化医療の基盤作成

    2018年 - 2020年

    日本学術振興会  科学研究費助成事業  若手研究

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    資金種別:科研費

教育活動概要

  • 4年生学生講義、5年生実習担当、6年生実習担当

担当授業科目

  • 眼科治療総論

    2025年4月  

  • 眼科治療総論

    2023年4月 - 2023年9月   前期

その他部局等における各種委員・役職等

  • 2023年4月 - 現在   その他 教官会代議員