Updated on 2024/09/09

Information

 

写真a

 
YAMASHITA KOJI
 
Organization
Kyushu University Hospital Radiology Lecturer
School of Medicine Department of Medicine(Joint Appointment)
Title
Lecturer
Tel
0926425695
Profile
○放射線画像診断 ・神経放射線診断 ・血管造影施行および報告書作成 ・経皮的椎体形成術 ・経皮的骨生検、椎間板生検施行および報告書作成 ○各診療科や放射線科内でのカンファレンス 脳神経外科:週3回のカンファレンス 脳腫瘍カンファレンス:脳神経外科および神経病理Dr.と病理組織診断が得られた患者についてディスカッションを行う。 神経内科カンファレンス 耳鼻咽喉科カンファレンス ○研究概要 CT・MRI装置を用いて主に臨床研究を行い、定期的に学会発表・論文作成を行う。円滑な研究遂行のため、科研費・助成金獲得に向けた取り組みも行う。 ・脳神経外科および神経病理学との共同研究:脳腫瘍画像所見と病理組織診断に関する検討 ・神経内科との共同研究:変性・代謝疾患の画像所見と臨床所見の関連 ・耳鼻咽喉科との共同研究:拡散強調像を含む、新しい撮像法を用いた真珠腫性中耳炎の検出能、判別能向上への取り組み、耳硬化症の画像診断 ・救命救急センターとの共同研究:CPA患者の画像所見と予後の相関 ・その他、整形外科・眼科・精神科・心療内科・小児科・産科婦人科等とも共同研究を行っている。 ・他科の臨床試験に際して画像の撮像条件・方法等に関する助言を行い、依頼に対するチェック・指示出し、得られた画像の読影等行う。 ○教育 医学部学生、研修医、大学院生に対して、画像診断教育及び読影指導を行う。

Degree

  • M.D., phD

Research Interests・Research Keywords

  • Research theme:Predicting gene mutation status using MR imaging in gliomas

    Keyword:Glioma, MR imaging, Radiogenomics

    Research period: 2017.4 - 2020.6

  • Research theme:Diagnostic utility of the combination of intravoxel incoherent motion MR imaging in diagnosing brain tumors

    Keyword:IVIM; MR; perfusion; GBM; PCNSL

    Research period: 2014.4 - 2017.3

  • Research theme:MR imaging of brain tumors using arterial spin labeling

    Keyword:ASL,MRI, brain tumor

    Research period: 2013.4 - 2016.3

  • Research theme:Diagnosis of middle-ear cholesteatoma on diffusion-weighted imaing

    Keyword:Cholesteatoma, temporal bone, MRI, Diffusion weighted imaging

    Research period: 2010.10

Papers

  • The cortical high-flow sign of oligodendroglioma, IDH-mutant and 1p/19q codeleted: comparison between arterial spin labeling and dynamic susceptibility contrast methods Reviewed International journal

    Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga MD, Yuhei Sangatsuda, Yutaka Fujioka, Koji Yoshimoto, Kousei Ishigami

    Neuroradiology   66 ( 2 )   187 - 192   2024.2   ISSN:0028-3940 eISSN:1432-1920

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    DOI: 10.1007/s00234-023-03267-x

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  • Cortical high-flow sign on arterial spin labeling: a novel biomarker of IDH-mutation and 1p/19q-codeletion status in diffuse gliomas without intense contrast enhancement. Reviewed International journal

    Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Yuhei Sangatsuda, Yutaka Fujioka, Izumi Kinoshita, Makoto Obara, Koji Yoshimoto, Kousei Ishigami

    Neuroradiology.   65 ( 9 )   1415 - 1418   2023.9   ISSN:0028-3940 eISSN:1432-1920

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    DOI: 10.1007/s00234-023-03186-x

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  • Interobserver reliability on intravoxel incoherent motion imaging in patients with acute ischemic stroke. Reviewed International journal

    Koji Yamashita, @Ryotaro Kamei, @Hiroshi Sugimori, @Takahiro Kuwashiro, @So Tokunaga, @Keisuke Kawamata, @Kiyomi Furuya, @Shino Harada, @Junki Maehara, @Yasushi Okada, @Tomoyuki Noguchi

    AJNR Am J Neuroradiol.   43 ( 5 )   696 - 700   2022.5   ISSN:01956108

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    DOI: 10.3174/ajnr.A7486

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  • MR imaging Based Analysis of Glioblastoma multiforme: Estimation of IDH1 Mutation Status. Reviewed International journal

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Koji Yoshimoto, Satoshi O Suzuki, Hiroshi Honda

    AJNR Am J Neuroradiol.   37 ( 1 )   58 - 65   2016.1

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  • High-resolution Three-dimensional Diffusion-weighted Imaging of Middle Ear Cholesteatoma at 3.0 T MRI: Usefulness of 3D Turbo Field-echo with Diffusion-Sensitized Driven-equilibrium Preparation (TFE-DSDE) Compared to Single-shot Echo-planar Imaging. Reviewed International journal

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Makoto Obara, Nozomu Matsumoto, Hiroshi Honda

    Eur J Radiol.   82 ( 9 )   471 - 475   2013.9

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    DOI: pii: S0720-048X(13)00214-3. 10.1016/j.ejrad.2013.04.018.

  • Differentiating primary central nervous system lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion weighted imaging, and 18F-fluorodeoxyglucose positron emission tomography. Reviewed International journal

    Yamashita K, Yoshiura T, Hiwatashi A, Togao O, Yoshimoto K, Suzuki SO, Abe K, Kikuchi K, Maruoka Y, Mizoguchi M, Iwaki T, Honda H

    Neuroradiology   55 ( 2 )   2013.2

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  • Detection of Middle Ear Cholesteatoma by Diffusion-Weighted MR Imaging: Multishot Echo-Planar Imaging Compared with Single-Shot Echo-Planar Imaging. Reviewed International journal

    Yamashita K, Yoshiura T, Hiwatashi A, Kamano H, Dashjamts T, Shibata S, Tamae A, Honda H.

    AJNR Am J Neuroradiol.   32 ( 10 )   2011.11

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  • Performance evaluation of radiologists with artificial neural network for differential diagnosis of intra-axial cerebral tumors on MR images Reviewed International journal

    Yamashita K, Yoshiura T, Arimura H, Mihara F, Noguchi T, Hiwatashi A, Togao O, Yamashita Y, Shono T, Kumazawa S, Higashida Y, Honda H

    Am J Neuroradiol.   2008.6

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  • Artificial intelligence-assisted volume isotropic simultaneous interleaved bright- and black-blood examination for brain metastases

    Kikuchi, K; Togao, O; Kikuchi, Y; Yamashita, K; Momosaka, D; Fukasawa, K; Nishimura, S; Toyoda, H; Obara, M; Hiwatashi, A; Ishigami, K

    NEURORADIOLOGY   2024.8   ISSN:0028-3940 eISSN:1432-1920

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  • Improvement of image quality for bright-blood image in VISIBLE (volume isotropic simultaneous interleaved bright- and black-blood examination) by using k-space reordering and startup echoes.

    Wada T, Kikuchi K, Obara M, Tokunaga C, Yamashita K, Kobayashi K, Kato T, Ishigami K, Togao O

    Magnetic resonance imaging   112   144 - 150   2024.7   ISSN:0730-725X

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    DOI: 10.1016/j.mri.2024.07.011

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  • Advantages of 3D High-Resolution Vessel Wall Imaging in a Patient With Blood Blister-Like Aneurysm: A Case Report and Literature Review

    Otsuka, T; Kikuchi, K; Togao, O; Yamashita, K; Takagishi, S; Arimura, K; Nakamizo, A; Ishigami, K

    CUREUS JOURNAL OF MEDICAL SCIENCE   16 ( 4 )   e58376   2024.4   ISSN:2168-8184 eISSN:2168-8184

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  • Advantages of 3D High-Resolution Vessel Wall Imaging in a Patient With Blood Blister-Like Aneurysm: A Case Report and Literature Review. Reviewed International journal

    Otsuka T, Kikuchi K, Togao O, Yamashita K, Takagishi S, Arimura K, Nakamizo A, Ishigami K.

    Cureus   16 ( 4 )   e58376   2024.4

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    DOI: 10.7759/cureus.58376.

  • Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function

    Kikuchi, K; Togao, O; Yamashita, K; Isoda, T; Nishimura, A; Arimura, K; Nakamizo, A; Yoshimoto, K; Ishigami, K

    SCIENTIFIC REPORTS   14 ( 1 )   5468   2024.3   ISSN:2045-2322

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    Moyamoya disease (MMD) is characterized by progressive arterial occlusion, causing chronic hemodynamic impairment, which can reduce brain volume. A novel quantitative technique, synthetic magnetic resonance imaging (SyMRI), can evaluate brain volume. This study aimed to investigate whether brain volume measured with SyMRI correlated with cerebral blood flow (CBF) and brain function in adult MMD. In this retrospective study, 18 adult patients with MMD were included. CBF was measured using iodine-123-N-isopropyl-p-iodoamphetamine single photon emission computed tomography. Cerebrovascular reactivity (CVR) to acetazolamide challenge was also evaluated. Brain function was measured using the Wechsler Adult Intelligence Scales (WAIS)-III/IV and the WAIS-R tests. Gray matter (GM), white matter, and myelin-correlated volumes were evaluated in six areas. Resting CBF was positively correlated with GM fractions in the right anterior cerebral arterial and right middle cerebral arterial (MCA) territories. CVR was positively correlated with GM fraction in the right posterior cerebral arterial (PCA) territory. Full-Scale Intelligence Quotient and Verbal Comprehension Index scores were marginally positively correlated with GM fractions in the left PCA territory. Processing Speed Index score was marginally positively correlated with GM fraction in the right MCA territory. The SyMRI-measured territorial GM fraction correlated with CBF and brain function in patients with MMD.

    DOI: 10.1038/s41598-024-56210-2

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  • Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function Reviewed International journal

    Kikuchi K, Togao O, Yamashita K, Isoda T, Nishimura A, Arimura K, Nakamizo A, Yoshimoto K, Ishigami K.

    Sci Rep.   14 ( 1 )   5468   2024.3

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    DOI: 10.1038/s41598-024-56210-2.

  • Diagnostic MR Imaging Features of Hypomyelination of Early Myelinating Structures: A Case Report. Reviewed International journal

    Tokiko Abe, Koji Yamashita, Kazufumi Kikuchi, Eriko Hatai, Fumihiko Fujii, Pin Fee Chong, Yasunari Sakai, @Hirotomo Saitsu, @Ken Inoue, Osamu Togao, Kousei Ishigami

    The Neuroradiology Journal   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/19714009231224419.

  • Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted Invited Reviewed International journal

    Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, @Daichi Momosaka, @Yoshitomo Kikuchi, Daisuke Kuga, Sangatsuda Yuhei, Yutaka Fujioka, Fumiya Narutomi, @Makoto Obara, Koji Yoshimoto, Kousei Ishigami

    Neuroradiology   66 ( 3 )   333 - 341   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00234-024-03288-0.

  • Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted

    Kikuchi, K; Togao, O; Yamashita, K; Momosaka, D; Kikuchi, Y; Kuga, D; Yuhei, S; Fujioka, Y; Narutomi, F; Obara, M; Yoshimoto, K; Ishigami, K

    NEURORADIOLOGY   66 ( 3 )   333 - 341   2024.3   ISSN:0028-3940 eISSN:1432-1920

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    Purpose: This study aimed to compare assessments by radiologists, artificial intelligence (AI), and quantitative measurement using synthetic MRI (SyMRI) for differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, and IDH-mutant and 1p/19q-codeleted and to identify the superior method. Methods: Thirty-three cases (men, 14; women, 19) comprising 19 astrocytomas and 14 oligodendrogliomas were evaluated. Four radiologists independently evaluated the presence of the T2-FLAIR mismatch sign. A 3D convolutional neural network (CNN) model was trained using 50 patients outside the test group (28 astrocytomas and 22 oligodendrogliomas) and transferred to evaluate the T2-FLAIR mismatch lesions in the test group. If the CNN labeled more than 50% of the T2-prolonged lesion area, the result was considered positive. The T1/T2-relaxation times and proton density (PD) derived from SyMRI were measured in both gliomas. Each quantitative parameter (T1, T2, and PD) was compared between gliomas using the Mann–Whitney U-test. Receiver-operating characteristic analysis was used to evaluate the diagnostic performance. Results: The mean sensitivity, specificity, and area under the curve (AUC) of radiologists vs. AI were 76.3% vs. 94.7%; 100% vs. 92.9%; and 0.880 vs. 0.938, respectively. The two types of diffuse gliomas could be differentiated using a cutoff value of 2290/128 ms for a combined 90th percentile of T1 and 10th percentile of T2 relaxation times with 94.4/100% sensitivity/specificity with an AUC of 0.981. Conclusion: Compared to the radiologists’ assessment using the T2-FLAIR mismatch sign, the AI and the SyMRI assessments increased both sensitivity and objectivity, resulting in improved diagnostic performance in differentiating gliomas.

    DOI: 10.1007/s00234-024-03288-0

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  • Refresher Course 脳神経関連で役立つMRI撮像技術:arterial spin labeling(ASL)

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   44 ( 3 )   361 - 373   2024.2   ISSN:02850524 eISSN:24321281

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    Publisher:学研メディカル秀潤社  

    DOI: 10.15105/gz.0000005316

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  • Diagnostic MR imaging features of hypomyelination of early myelinating structures: A case report

    Abe, T; Yamashita, K; Kikuchi, K; Hatai, E; Fujii, F; Chong, PF; Sakai, Y; Saitsu, H; Inoue, K; Togao, O; Ishigami, K

    NEURORADIOLOGY JOURNAL   19714009231224419   2023.12   ISSN:1971-4009 eISSN:2385-1996

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    Hypomyelination of early myelinating structures (HEMS) has recently been defined as a new genetic disorder accompanied by clinical and MR imaging characteristics. However, no studies have focused on diffusion-weighted imaging (DWI) findings of HEMS. We would like to propose a “sheep sign,” which is formed by DWI hyperintensity in the medial medullary lamina along with alternating high-low-high (HLH) intensity stripes in the posterior limb of the internal capsule. We believe the presence of the “sheep sign” on DWI in combination with alternating HLH intensity stripes may be a valuable tool for diagnosing HEMS.

    DOI: 10.1177/19714009231224419

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  • Reproducibility of quantitative ADC, T1, and T2 measurement on the cerebral cortex: Utility of whole brain echo-planar DWI with compressed SENSE (EPICS-DWI): A pilot study Reviewed International journal

    Koji Yamashita, @Masami Yoneyama, Kazufumi Kikuchi, Tatsuhiro Wada, Hiroo Murazaki, Hiroaki Watanuki, Ryoji Mikayama, Kousei Ishigami, Osamu Togao

    Eur J Radiol Open   11   100516   2023.12

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  • Reproducibility of quantitative ADC, T1, and T2 measurement on the cerebral cortex: Utility of whole brain echo-planar DWI with compressed SENSE (EPICS-DWI): A pilot study

    Yamashita, K; Yoneyama, M; Kikuchi, K; Wada, T; Murazaki, H; Watanuki, H; Mikayama, R; Ishigami, K; Togao, O

    EUROPEAN JOURNAL OF RADIOLOGY OPEN   11   100516   2023.12   ISSN:2352-0477 eISSN:2352-0477

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    Language:English   Publisher:European Journal of Radiology Open  

    Purpose: To assess the reproducibility of ADC, T1, T2, and proton density (PD) measurements on the cortex across the entire brain using high-resolution pseudo-3D diffusion-weighted imaging using echo-planar imaging with compressed SENSE (EPICS-DWI) and 3D quantification with an interleaved Look-Locker acquisition sequence with T2 preparation pulse (3D-QALAS) in normal healthy adults. Methods: Twelve healthy participants (median age, 33 years; range, 28–51 years) were recruited to evaluate the reproducibility of whole-brain EPICS-DWI and synthetic MRI. EPICS-DWI utilizes a compressed SENSE reconstruction framework while maintaining the EPI sampling pattern. The 3D-QALAS sequence is based on multi-acquisition 3D gradient echo, with five acquisitions equally spaced in time, interleaved with a T2 preparation pulse and an inversion pulse. EPICS-DWI (b values, 0 and 1000 s/mm2) and 3D-QALAS sequence with identical voxel size on a 3.0-T MR system were performed twice (for test-retest scan). Intraclass correlation coefficients (ICCs) for ADC, T1, T2, and PD for all parcellated volume of interest (VOI) per subject on scan-rescan tests were calculated to assess reproducibility. Bland-Altman plots were used to investigate discrepancies in ADCs, T1s, T2s, and PDs obtained from the two MR scans. Results: The ICC of ADCs was 0.785, indicating “good” reproducibility. The ICCs of T1s, T2s, and PDs were 0.986, 0.978, and 0.968, indicating “excellent” reproducibility. Conclusion: The combination of EPICS-DWI and 3D-QALAS sequences with identical voxel size could reproducible ADC, T1, T2, and PD measurements for the cortex across the entire brain in healthy adults.

    DOI: 10.1016/j.ejro.2023.100516

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  • Arterial Spin Labeling-Based MR Angiography for Cerebrovascular Diseases: Principles and Clinical Applications

    Togao, O; Obara, M; Yamashita, K; Kikuchi, K; Wada, T; Murazaki, H; Arimura, K; Nishimura, A; Horie, N; van de Ven, K; Van Cauteren, M; Ishigami, K

    JOURNAL OF MAGNETIC RESONANCE IMAGING   2023.11   ISSN:1053-1807 eISSN:1522-2586

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    Arterial spin labeling (ASL) is a noninvasive imaging technique that labels the proton spins in arterial blood and uses them as endogenous tracers. Brain perfusion imaging with ASL is becoming increasingly common in clinical practice, and clinical applications of ASL for intracranial magnetic resonance angiography (MRA) have also been demonstrated. Unlike computed tomography (CT) angiography and cerebral angiography, ASL-based MRA does not require contrast agents. ASL-based MRA overcomes most of the disadvantages of time-of-flight (TOF) MRA. Several schemes have been developed for ASL-based MRA; the most common method has been pulsed ASL, but more recently pseudo-continuous ASL, which provides a higher signal-to-noise ratio (SNR), has been used more frequently. New methods that have been developed include direct intracranial labeling methods such as velocity-selective ASL and acceleration-selective ASL. MRA using an extremely short echo time (eg, silent MRA) or ultrashort echo-time (TE) MRA can suppress metal susceptibility artifacts and is ideal for patients with a metallic device implanted in a cerebral vessel. Vessel-selective 4D ASL MRA can provide digital subtraction angiography (DSA)-like images. This review highlights the principles, clinical applications, and characteristics of various ASL-based MRA techniques. Level of Evidence: 5. Technical Efficacy: Stage 2.

    DOI: 10.1002/jmri.29119

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  • Cortical high-flow sign on arterial spin labeling: a novel biomarker for IDH-mutation and 1p/19q-codeletion status in diffuse gliomas without intense contrast enhancement (vol 65, pg 1415, 2023)

    Yamashita, K; Togao, O; Kikuchi, K; Kuga, D; Sangatsuda, Y; Fujioka, Y; Kinoshita, I; Obara, M; Yoshimoto, K; Ishigami, K

    NEURORADIOLOGY   65 ( 11 )   1675 - 1676   2023.11   ISSN:0028-3940 eISSN:1432-1920

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    The original article contains an error during online publication. There was an error in the previous version of Table 2. Specifically, the values of rrTBF for IDHm-noncodel and IDHm-codel were identical at 1.24 ± 1.23 [0.76–1.71]. The authors have provided a corrected version below. (Table presented.) Differences between IDHw, IDHm-noncodel and IDHm-codel in the ASL parameters IDHw (n = 21) IDHm-noncodel (n = 28) IDHm-codel (n = 22) P-value ASL Cortical high-flow sign 2/21(9.5%) 2/28(7.1%) 12/22(54.5%) <0.0001* rrTBF 1.31 ± 0.56 [1.05–1.56] 1.24 ± 1.23 [0.76–1.71] 1.31 ± 0.60 [1.05–1.58] 0.9473 *p < 0.05

    DOI: 10.1007/s00234-023-03228-4

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  • Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study

    Motomura, Y; Fukuzaki, A; Eto, S; Hirabayashi, N; Gondo, M; Izuno, S; Togao, O; Yamashita, K; Kikuchi, K; Sudo, N; Yoshihara, K

    JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY   42 ( 1 )   18   2023.9   ISSN:1880-6805

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    Language:English   Publisher:Journal of Physiological Anthropology  

    Background: Alexithymia, a personality trait characterized by difficulties in identifying and expressing their emotions despite having a range of emotional experiences, can impact individuals’ stress coping mechanisms. While many studies have investigated brain functions associated with specific tasks in relation to emotion processing, research focusing on resting-state brain functions has been limited. Thus, the aim of this study was to investigate the relationship between alexithymia and brain function by analyzing arterial spin labeling (ASL) data obtained during the resting state. Methods: A brain structural and functional imaging study was conducted on 42 healthy adult men and women using ASL and the 20-item Toronto Alexithymia Scale (TAS-20) questionnaire survey. Cerebral blood flow and functional connectivity values were calculated for regions of interest in the default mode network, saliency network, and central executive network from the ASL data. Correlation analysis was performed with TAS20 scores, and partial correlation analysis was conducted to control for anxiety and depression. Results: The functional connectivity analysis revealed a negative correlation between the functional connectivity of the right insular cortex and left anterior cingulate cortex and the total score of TAS, as well as difficulty identifying feelings and difficulty describing feeling subscores, indicating that the higher the scores, the weaker the functional connectivity between these regions (T = -3.830, p = 0.0013, R = -0.5180). This correlation remained significant even after controlling for anxiety and depression using partial correlation analysis. Conclusion: The present study revealed differences in the activity of the Saliency Network at rest as measured by ASL, which were independent of anxiety and depression, and varied depending on the severity of alexithymia. This functional change may underlie the neural basis of decreased emotional processing observed in alexithymia. These findings may contribute to the elucidation of the neural mechanisms of alexithymia, which can lead to social impairments, and suggest the usefulness of ASL measurement as a biomarker of alexithymia.

    DOI: 10.1186/s40101-023-00336-1

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  • Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study(タイトル和訳中)

    Motomura Yuki, Fukuzaki Ayaka, Eto Sanami, Hirabayashi Naoki, Gondo Motoharu, Izuno Satoshi, Togao Osamu, Yamashita Koji, Kikuchi Kazufumi, Sudo Nobuyuki, Yoshihara Kazufumi

    Journal of Physiological Anthropology   42   1 of 13 - 13 of 13   2023.9   ISSN:1880-6791

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    Language:English   Publisher:(一社)日本生理人類学会  

  • 特集 WHO脳腫瘍分類 第5版 徹底解説 Case-based review 4. Diffuse hemispheric glioma, H3 G34-mutant

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   43 ( 10 )   988 - 992   2023.8   ISSN:02850524 eISSN:24321281

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    DOI: 10.15105/gz.0000004785

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  • 特集 WHO脳腫瘍分類 第5版 徹底解説 Case-based review 7. High-grade astrocytoma with piloid features

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生, 黒川 遼, 森谷 聡男

    画像診断   43 ( 10 )   998 - 1000   2023.8   ISSN:02850524 eISSN:24321281

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    DOI: 10.15105/gz.0000004788

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  • Alexithymia characteristics are associated with salience network activity in healthy participants: An Arterial Spin Labeling Study Reviewed International journal

    Motomuta Y, Fukuzaki A, Eto S, Hirabayashi N, Gondo M, Izuno S, Togao O, Yamashita K, Kikuchi K

    J Physiol Anthropol   2023.8

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  • The T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase wild-type Reviewed International journal

    Shunsuke Nishimura, Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Hidetaka Yamamoto, Koji Yoshimoto, Kousei Ishigami

    Acta Radiologica Open   12 ( 6 )   20584601231184565   2023.6   ISSN:2058-4601 eISSN:2058-4601

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    DOI: 10.1177/20584601231184565

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  • Predicting TERT promoter mutation status using 1H-MR spectroscopy and stretched-exponential model of diffusion-weighted imaging in IDH-wildtype diffuse astrocytic glioma without intense enhancement Reviewed International journal

    Koji Yamashita, Ryusuke Hatae, Kazufumi Kikuchi, Daisuke Kuga, Nobuhiro Hata, Hidetaka Yamamoto, Makoto Obara, Koji Yoshimoto, Kousei Ishigami, Osamu Togao

    Neuroradiology   65 ( 8 )   1205 - 1213   2023.6   ISSN:0028-3940 eISSN:1432-1920

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    DOI: 10.1007/s00234-023-03177-y

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  • Assessment of cerebral perfusion in moyamoya disease with dynamic pseudo-continuous arterial spin labeling using a variable repetition time scheme with optimized background suppression

    Togao, O; Obara, M; Yamashita, K; Kikuchi, K; Arimura, K; Nishimura, A; Nakamizo, A; Wada, T; Tokunaga, C; Mikayama, R; Yamashita, Y; Hamano, H; Van Cauteren, M; Ishigami, K; Baba, S

    NEURORADIOLOGY   65 ( 3 )   529 - 538   2023.3   ISSN:0028-3940 eISSN:1432-1920

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    Purpose: Accurate assessment of cerebral perfusion in moyamoya disease is necessary to determine the indication for treatment. We aimed to investigate the usefulness of dynamic PCASL using a variable TR scheme with optimized background suppression in the evaluation of cerebral perfusion in moyamoya disease. Methods: We retrospectively analyzed the images of 24 patients (6 men and 18 women, mean age 31.4 ± 18.2 years) with moyamoya disease; each of whom was imaged with both dynamic PCASL using the variable-TR scheme and 123IMP SPECT with acetazolamide challenge. ASL dynamic data at 10 phases are acquired by changing the LD and PLD. The background suppression timing was optimized for each phase. CBF and ATT were measured with ASL, and CBF and CVR to an acetazolamide challenge were measured with SPECT. Results: A significant moderate correlation was found between the CBF measured by dynamic PCASL and that by SPECT (r = 0.53, P < 0.001). The CBF measured by dynamic PCASL (52.5 ± 13.3 ml/100 mg/min) was significantly higher than that measured by SPECT (43.0 ± 12.6 ml/100 mg/min, P < 0.001). The ATT measured by dynamic PCASL showed a significant correlation with the CVR measured by SPECT (r = 0.44, P < 0.001). ATT was significantly longer in areas where the CVR was impaired (CVR < 18.4%, ATT = 1812 ± 353 ms) than in areas where it was preserved (CVR > 18.4%, ATT = 1301 ± 437 ms, P < 0.001). The ROC analysis showed a moderate accuracy (AUC = 0.807, sensitivity = 87.7%, specificity = 70.4%) when the cutoff value of ATT was set at 1518 ms. Conclusion: Dynamic PCASL using this scheme was found to be useful for assessing cerebral perfusion in moyamoya disease.

    DOI: 10.1007/s00234-022-03095-5

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  • Analysis of “visible in retrospect” to monitor false-negative findings in radiological reports

    Noguchi T., Yamashita K., Matsuura S., Kamei R., Maehara J., Furuya K., Harada S., Adachi S., Okada Y.

    Japanese Journal of Radiology   41 ( 2 )   219 - 227   2023.2   ISSN:18671071

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    Purpose: False-negative findings in radiological reports can lead to serious adverse patient outcomes. We determined the frequency and tendency of false-negative findings in radiological reports by searching for words related to “visible in retrospect”. Methods: In the period of 34 months, we extracted radiological reports containing words related to “visible in retrospect”. Of these reports, we extracted false-negative findings that were not described in past reports and were first detected retrospectively. Misinterpretations were excluded. The occurrences of the terms that we identified were analyzed by all examinations, modality, month, and anatomical and lesion classifications were analyzed. Results: Of the 135,251 examinations, 941 reports (0.71%) with 962 findings were detected, with an average of 1.4 findings per business day. By modality, 713 of 81,899 (0.87%) CT examinations, 208 of 36,174 (0.57%) MR, 34 of 9,585 (0.35%) FDG-PET-CT, 2 of 2,258 (0.09%) digital radiography, and 5 of 5,335 (0.09%) other nuclear medicine examinations were found. By anatomical classification, there were 383 (40%) in chest, 353 (37%) in abdomen, 162 (17%) in head, 42 (4.4%) in face and neck, 9 (0.93%) in extremity, and 13 (1.4%) in others. By lesion classification, we identified 665 (69%) for localized lesion, 170 (18%) for vascular lesion, 83 (8.6%) for inflammatory lesion, 14 (1.5%) for traumatic lesion, 12 (1.2%) for organ dysfunction, 11 (1.1%) for degenerative lesion, and 7 (0.7%) for the others. Notable high-frequency specific site diseases by modality were 210 (22%) of localized lesions in lung on CT. Conclusion: Our results demonstrated that missed lung localized lesions on CT, which account for about a fifth of false-negative findings, were the most common false-negative finding.

    DOI: 10.1007/s11604-022-01338-2

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  • 放射線診断報告書の偽陰性所見を監視するための「後方視認性」に関する解析(Analysis of "visible in retrospect" to monitor false-negative findings in radiological reports)

    Noguchi Tomoyuki, Yamashita Koji, Matsuura Shuji, Kamei Ryotaro, Maehara Junki, Furuya Kiyomi, Harada Shino, Adachi Saki, Okada Yasushi

    Japanese Journal of Radiology   41 ( 2 )   219 - 227   2023.2   ISSN:1867-1071

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    2018年10月~2021年7月までの期間内に、著者らの所属する医療施設で報告された135251件の放射線診断報告書について、「後方視認性(visible in retrospect)」に関連する用語を検索した。その結果、962件の偽陰性所見を含む941件の報告書が検出され、各画像モダリティによる所見数ではCTが713件、MRが208件、FDG-PET-CTが34件、デジタルX線撮影法が2件、その他の核医学検査が5件であった。また、所見の解剖学分類では胸部が383件(40%)、腹部が353件(37%)、頭部が162件(17%)、顔面と頸部が42件(4.4%)、四肢が9件(0.93%)、その他が13件(1.4%)であった。なお、病変分類別では限局性病変が665件(69%)、血管病変が170件(18%)、炎症性病変が83件(8.6%)、外傷性病変が14件(1.5%)、臓器機能不全が12件(1.2%)、変性性病変が11件(1.1%)、その他病変が7件(0.7%)で、特にCT上の肺限局性病変では22%も認められた。本研究結果から、CT上で見逃された肺限局性病変は、全体の約1/5を占める最も一般的な偽陰性所見であることが明らかにされた。

  • Grading of gliomas using 3D CEST imaging with compressed sensing and sensitivity encoding

    Wada, T; Togao, O; Tokunaga, C; Oga, M; Kikuchi, K; Yamashita, K; Yamamoto, H; Yoneyama, M; Kobayashi, K; Kato, T; Ishigami, K; Yabuuchi, H

    EUROPEAN JOURNAL OF RADIOLOGY   158   110654   2023.1   ISSN:0720-048X eISSN:1872-7727

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    Purpose: We evaluated the usefulness of three-dimensional (3D) chemical exchange saturation transfer (CEST) imaging with compressed sensing and sensitivity encoding (CS-SENSE) for differentiating low-grade gliomas (LGGs) from high-grade gliomas (HGGs). Methods: We evaluated 28 patients (mean age 51.0 ± 13.9 years, 13 males, 15 females) including 12 with LGGs and 16 with HGGs, all acquired using a 3 T magnetic resonance (MR) scanner. Nine slices were acquired for 3D CEST imaging, and one slice was acquired for two-dimensional (2D) CEST imaging. Two radiological technologists each drew a region of interest (ROI) surrounding the high-signal-intensity area(s) on the fluid-attenuated inversion recovery image of each patient. We compared the magnetization transfer ratio asymmetry (MTRasym) at 3.5 ppm in the tumors among the (i) single-slice 2D CEST imaging (“2D”), (ii) all tumor slices of the 3D CEST imaging (3Dall), and (iii) a representative tumor slice of 3D CEST imaging (maximum signal intensity [3Dmax]). The relationship between the MTRasym at 3.5 ppm values measured by these three methods and the Ki-67 labeling index (LI) of the tumors was assessed. Diagnostic performance was evaluated with a receiver operating characteristic analysis. The Ki-67LI and MTRasym at 3.5 ppm values were compared between the LGGs and HGGs. Results: A moderate positive correlation between the MTRasym at 3.5 ppm and the Ki-67LI was observed with all three methods. All methods proved a significantly larger MTRasym at 3.5 ppm for the HGGs compared to the LGGs. All methods showed equivalent diagnostic performance. The signal intensity varied depending on the slice position in each case. Conclusions: The 3D CEST imaging provided the MTRasym at 3.5 ppm for each slice cross-section; its diagnostic performance was also equivalent to that of 2D CEST imaging.

    DOI: 10.1016/j.ejrad.2022.110654

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  • Right adrenal vein identification using unenhanced MR imaging. Reviewed International journal

    Koji Yamashita, Noriaki Wada, @Seitaro Shin, @Tetsuhiro Watanabe, @Kiyomi Furuya, @Shino Harada, @Tomoyuki Noguchi

    Pol J Radiol.   87   e592 - e596   2022.11

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  • Analysis of “Visible in retrospect” to monitor false-negative findings in radiological reports Reviewed International journal

    2022.10

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  • ray-summation画像を用いた脊椎穿刺シミュレーショントレーニングシステムの有用性 実験的研究(The usefulness of vertebral needle targeting simulation training system using ray-summation imaging: experimental study)

    Uchiyama Fumiya, Noguchi Tomoyuki, Kamei Shunsuke, Yamashita Koji, Shida Yoshitaka, Okafuji Takashi, Kamei Ryotaro, Tajima Tsuyoshi

    Japanese Journal of Radiology   40 ( 10 )   1096 - 1103   2022.10   ISSN:1867-1071

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    今回、マルチスライスCT(MDCT)と3次元画像により仮想下で椎骨(脊椎)穿刺シミュレーションのトレーニングシステムが行える"SNIPURS"を開発し、診療放射線研修医の学習曲線の変化を評価することでSNIPURSの有用性を検証した。経皮的椎体形成術(PVP)施術歴を有するエキスパート群、指導者により穿刺法の教育訓練を受けたコーチングあり群、コーチングを受けていないコーチングなし群に分け、各群7名全21名を評価した。2014年4月~2017年12月までの期間内に、著者らの医療施設で脊椎骨折に対しPVPが施行された継続患者199例から得た6例の胸腰部脊椎MDCT画像データを選択し、ワークステーションで生成したray-summation画像をテストとして評価した。また、各テストでは画像上の2胸椎と2腰椎の両側経椎弓根穿刺点と角度を決定し、コーチあり群では、テスト1と4の後にコーチングを受けた。経椎弓根経路(1点)とそれ以外(0点)でスコア付けし、各6テストで8つの仮想針を評価した結果、3群間ではエキスパート群がテスト1~4で最も平均スコアが高く、次にコーチあり群、コーチなし群の順であった。また、テスト5、6ではコーチあり群のスコアがエキスパート群の平均スコアに近かったが、コーチなし群では差異が認められ、エキスパート群とコーチあり群でテストを受けた全ての研修医では、最終テスト6でスコアが満点に達したが、コーチなし群では到達しなかった。以上より、SNIPURSは椎骨穿刺トレーニングに有用で、SNIPURSトレーニング中に行うコーチングは、研修医がPVPにおいて脊椎穿刺技術を修得する一助になり得ることが期待された。

  • The usefulness of vertebral needle targeting simulation training system using ray-summation imaging: experimental study

    Uchiyama F., Noguchi T., Kamei S., Yamashita K., Shida Y., Okafuji T., Kamei R., Tajima T.

    Japanese Journal of Radiology   40 ( 10 )   1096 - 1103   2022.10   ISSN:18671071

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    Purpose: Using the multi-detector computed tomography and related three-dimensional imaging technology, we developed a vertebral needle targeting simulation training system named spinal needling intervention practice using ray-summation imaging (SNIPURS). Herein, we assessed the utility of SNIPURS by evaluating changes in the learning curves of SNIPURS trainees. Methods: Twenty-one examinees were enrolled: seven experienced operators (expert group), seven trainees with coaching (coaching group), and seven trainees without coaching (non-coaching group). They performed six tests of vertebral needle targeting simulation on the workstation-generated spinal ray-summation images of six patients with vertebral fractures. In each test, they determined the bilateral trans-pedicular puncture points and angles on two thoracic and two lumbar vertebrae on ray-summation imaging (i.e., 8 simulations per test). The coaching group received coaching by a trainer after Tests 1 and 4, while the others did not. Scores were given based on the trans-pedicular pathway (1 point) or not (0 point). Eight virtual needles were evaluated in each of Tests 1–6. Results: Among the three groups, the expert group had the highest average scores on Tests 1–4 (expert: 3.86, 6.57, 7.43, and 7.57; coaching: 1.86, 6.14, 6, and 6.29; and non-coaching: 1.14, 4.14, 4.71, and 4.86). The coaching group’s scores caught up with the expert groups’ average scores on Tests 5 and 6, whereas those of the non-coaching group did not (expert and coaching: 7.86 and 8.00, non-coaching: 5.86 and 7.14). All examinees in the expert and coaching groups achieved a perfect score on the final Test 6, whereas three of the seven non-coaching trainees did not. Conclusion: SNIPURS might be suitable for vertebral needle targeting training. The coaching provided during SNIPURS training helped the trainees to acquire the spinal puncture techniques in PVP.

    DOI: 10.1007/s11604-022-01291-0

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  • Current status and challenges of percutaneous vertebroplasty (PVP): a review Reviewed International journal

    @Noguchi T, Yamashita K, @Kamei R, @Maehara J

    Jpn J Radiol.   41 ( 1 )   1 - 13   2022.8   ISSN:18671071

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    DOI: 10.1007/s11604-022-01322-w

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  • Quantitative Relaxometry using Synthetic MRI Could be Better than Qualitative T2-FLAIR Mismatch Sign: A Pilot Study. Reviewed International journal

    Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Yoshitomo Kikuchi, Daisuke Kuga, Nobuhiro Hata, Masahiro Mizoguchi, Hidetaka Yamamoto, Toru Iwaki, Akio Hiwatashi, Kousei Ishigami

    Scientific Reports   12 ( 1 )   9197   2022.6   ISSN:2045-2322

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    DOI: 10.1038/s41598-022-13036-0

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  • Unusual imaging characteristics of cystic meningioma at the cerebellopontine angle. Reviewed International journal

    @Saki Adachi, Koji Yamashita, Akira Nakamizo, @Toshiyuki Amano, @Seiya Momosaki, @Tomoyuki Noguchi

    Neuroradiol J.   35 ( 6 )   777 - 779   2022.5   ISSN:19714009

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    DOI: 10.1177/19714009221096831

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  • Different hemodynamics of basal ganglia between moyamoya and non-moyamoya diseases using intravoxel incoherent motion imaging and single-photon emission computed tomography. Reviewed International journal

    Koji Yamashita,@Hiroshi Sugimori, Akira Nakamizo, @Toshiyuki Amano, @Takahiro Kuwashiro, @Takeharu Watanabe, @Keisuke Kawamata, @Kiyomi Furuya, @Shino Harada, @Ryotaro Kamei, @Junki Maehara, @Yasushi Okada, @Tomoyuki Noguchi

    Acta Radiologica.   64 ( 2 )   769 - 775   2022.5   ISSN:02841851

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    DOI: 10.1177/02841851221092895

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  • The usefulness of vertebral needle targeting simulation training system using ray-summation imaging: Experimental study Reviewed International journal

    @Fumiya Uchiyama, @Tomoyuki Noguchi, @Shunsuke Kamei, Koji Yamashita, @Yoshitaka Shida, @Takashi Okafuji, @Ryotaro Kamei, @Junki Maehara, @Tsuyoshi Tajima

    Jpn J Radiol.   2022.5

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  • Accuracy of vertebral puncture in percutaneous vertebroplasty. Reviewed International journal

    @Tomoyuki Noguchi, Koji Yamashita, @Yoshitaka Shida, @Takashi Okafuji, @Ryotaro Kamei, @Junki Maehara, @Tsuyoshi Tajima

    Jpn J Radiol.   2022.4

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  • Accuracy of vertebral puncture in percutaneous vertebroplasty

    Noguchi T., Yamashita K., Shida Y., Okafuji T., Kamei R., Maehara J., Tajima T.

    Japanese Journal of Radiology   40 ( 4 )   419 - 429   2022.4   ISSN:18671071

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    Purpose: To clarify the accuracy of vertebral puncture of the vertebral tertile area needling (VETERAN) method puncturing the pedicle superimposed on one-third of the width between the lateral vertebral line to the contralateral medial lamina line compared with Cathelin-needle-assisted puncture (CAP) method puncturing using the Cathelin needle as a guide in percutaneous vertebroplasty. Materials and methods: 449 punctures by CAP method and 125 punctures by VETERAN method were enrolled. We compared the puncture accuracy of both methods. We estimated a vertebral estimated tilting ratio (VET-ratio) defined as ratio of the distance between the lateral vertebral line and the contralateral medial laminal line to the distance between the vertebral lateral line and the puncture point measured by computed tomography. We also estimated the procedural items and clinical outcomes. Results: VETERAN method with 100% of punctures within safe zone (cortical breaches within 2 mm) had significantly higher accuracy than CAP method with 97.8% (p < 0.01) for the 2 mm incremental evaluation. No cases with a VET-ratio of 36% or less had cortical breaches. VETERAN method had shorter operative time per puncture (p < 0.01) and exposure time per puncture (p < 0.05). Conclusion: VETERAN method reduced the occurrence of the inaccurate puncture, operative times, and exposure times. A VET-ratio with 36% or less is associated with a safe puncture using VETERAN method.

    DOI: 10.1007/s11604-021-01216-3

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  • 経皮的椎体形成術における椎体穿刺の精度(Accuracy of vertebral puncture in percutaneous vertebroplasty)

    Noguchi Tomoyuki, Yamashita Koji, Shida Yoshitaka, Okafuji Takashi, Kamei Ryotaro, Maehara Junki, Tajima Tsuyoshi

    Japanese Journal of Radiology   40 ( 4 )   419 - 429   2022.4   ISSN:1867-1071

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    経皮的椎体形成術(PVP)における椎体穿刺で、カテラン針ガイド下穿刺(CAP)法と椎体三分位針穿刺(VETERAN)法の穿刺精度を比較した。なお、VETERAN法では対側の内側髄板線と側方脊柱線間幅の1/3部位に椎弓根を重ねて穿刺した。2015年5月~2019年1月までの期間内に、著者等の医療施設で治療を受けた、非治癒の胸椎骨折患者もしくは腰椎骨折患者563例のうち、PVPが施行された178例を対象とし、CAP法が適用された139例(男性52例、女性87例、年齢46~92歳)449穿刺と、VETERAN法が適用された39例(男性14例、女性25例、年齢39~93歳)125穿刺に群分けした。CTで計測した側方脊柱線と穿刺点間距離に対する対側の内側髄板線、および側方脊柱線間距離比で定義した椎体推定傾斜(VET)比や施術時間を比較した結果、安全領域(2mm以内の皮質破壊)内での穿刺が100%のVETERAN法では、2mm以上による評価で97.8%であったCAP法に比べ、有意に高精度であることが確認され、36%以下のVET比を有する症例も0例であった。また、VETERAN法では穿刺当たりの施術時間と、穿刺当たりの曝露時間の短縮化も達成されていた。以上より、PVPにおける椎体穿刺法による精度と比べ、安全領域への穿刺はVETERAN法では100%、CAP法では97.8%得られ、Gertzbein & Robbins分類スコアによる判定でも、両手法とも臨床的に許容範囲内の精度ではあるが、VETERAN法を採用することにより、不正確な穿刺や、手術時間および曝露時間が低減されることが期待された。

  • 特集 癌治療後の画像変化と合併症 肝細胞癌の治療後画像変化と合併症

    前原 純樹, 亀井 僚太郎, 山下 孝二, 野口 智幸, 石神 康生

    臨床放射線   67 ( 2 )   139 - 150   2022.2   ISSN:00099252

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    DOI: 10.18888/rp.0000001847

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  • Unilateral agenesis of internal carotid artery with interparaclinoid and contralateral carotid-anterior cerebral artery anastomoses diagnosed by magnetic resonance angiography: a case report. Reviewed International journal

    Yamashita K, @Yasaka M, @Uchino A, @Noguchi T.

    Surg Radiol Anat.   2022.2

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    DOI: 10.1007/s00276-021-02844-0.

  • Right entorhinal cortical thickness is associated with Mini-Mental State Examination scores from multi-country datasets. Reviewed International journal

    Koji Yamashita, @Takahiro Kuwashiro, @Kensuke Ishikawa, @Kiyomi Furuya, @Shino Harada, @Seitaro Shin, @Noriaki Wada, @Chika Hirakawa, @Yasushi Okada, @Tomoyuki Noguchi

    Neuroradiology   64 ( 2 )   279 - 288   2022.2

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    DOI: 10.1007/s00234-021-02767-y.

  • Unilateral agenesis of internal carotid artery with interparaclinoid and contralateral carotid-anterior cerebral artery anastomoses diagnosed by magnetic resonance angiography: a case report

    Yamashita K., Yasaka M., Uchino A., Noguchi T.

    Surgical and Radiologic Anatomy   44 ( 2 )   289 - 292   2022.2   ISSN:09301038

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    Purpose: Unilateral agenesis of the internal carotid artery (ICA) is a rare anatomical variant. We identified a case of unilateral ICA agenesis with interparaclinoid and contralateral carotid-ACA anastomoses. Methods: A 65-year-old female with a long history of depressive episodes underwent MR imaging including MR angiography at National Hospital Organization Kyushu Medical Center. MR imaging was performed using a 3.0-T MR scanner to rule out vascular Parkinsonism, although drug-induced Parkinsonism was suspected from her medical history. Results: The proximal left ICA was not visible on MR angiography, and an anterior communicating artery (ACoA) aneurysm was identified. The left middle cerebral artery was supplied from the right ICA via an interparaclinoid anastomosis. This interparaclinoid anastomosis showed no communication with the basilar, posterior communicating, or posterior cerebral arteries. A communicating artery connecting the interparaclinoid anastomosis and anterior cerebral artery (ACA) branched off from the presumed transition point between the interparaclinoid anastomosis and left ICA. Both right and left ophthalmic arteries (OAs) originated from the clinoid segment of the ICA. The communicating artery connecting the interparaclinoid anastomosis and ACA arose proximal to the left OA, and the communicating artery was identified as the carotid-ACA anastomosis. Conclusion: Neuroradiologists, physicians, and neurosurgeons need to be aware of this extremely unusual anatomical variant to determine appropriate treatment strategies in cases of aneurysmal growth or anterior cranial base surgery.

    DOI: 10.1007/s00276-021-02844-0

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  • Right entorhinal cortical thickness is associated with Mini-Mental State Examination scores from multi-country datasets using MRI

    Yamashita K., Kuwashiro T., Ishikawa K., Furuya K., Harada S., Shin S., Wada N., Hirakawa C., Okada Y., Noguchi T.

    Neuroradiology   64 ( 2 )   279 - 288   2022.2   ISSN:00283940

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    Purpose: To discover common biomarkers correlating with the Mini-Mental State Examination (MMSE) scores from multi-country MRI datasets. Methods: The first dataset comprised 112 subjects (49 men, 63 women; range, 46–94 years) at the National Hospital Organization Kyushu Medical Center. A second dataset comprised 300 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (177 men, 123 women; range, 57–91 years). Three-dimensional T1-weighted MR images were collected from both datasets. In total, 14 deep gray matter volumes and 70 cortical thicknesses were obtained from MR images using FreeSurfer software. Total hippocampal volume and the ratio of hippocampus to cerebral volume were also calculated. Correlations between each variable and MMSE scores were assessed using Pearson’s correlation coefficient. Parameters with moderate correlation coefficients (r > 0.3) from each dataset were determined as independent variables and evaluated using general linear model (GLM) analyses. Results: In Pearson’s correlation coefficient, total and bilateral hippocampal volumes, right amygdala volume, and right entorhinal cortex (ERC) thickness showed moderate correlation coefficients (r > 0.3) with MMSE scores from the first dataset. The ADNI dataset showed moderate correlations with MMSE scores in more variables, including bilateral ERC thickness and hippocampal volume. GLM analysis revealed that right ERC thickness correlated significantly with MMSE score in both datasets. Cortical thicknesses of the left parahippocampal gyrus, left inferior parietal lobe, and right fusiform gyrus also significantly correlated with MMSE score in the ADNI dataset (p < 0.05). Conclusion: A positive correlation between right ERC thickness and MMSE score was identified from multi-country datasets.

    DOI: 10.1007/s00234-021-02767-y

    Scopus

  • Preoperative prediction of intracranial meningioma grade using conventional computed tomography and magnetic resonance imaging. Reviewed International journal

    @Amano T, Nakamizo A, @Murata H, @Miyamatsu Y, @Mugita F, Yamashita K, @Noguchi T, @Nagata S.

    Cureus   2022.1

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  • Right adrenal vein identification using unenhanced magnetic resonance imaging

    Yamashita K., Wada N., Shin S., Watanabe T., Furuya K., Harada S., Noguchi T.

    Polish Journal of Radiology   87 ( 1 )   592 - 596   2022   ISSN:1733134X

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    Purpose: Unenhanced magnetic resonance imaging (MRI) is known to be useful in characterizing adrenal adenomas through the implementation of in-phase (IPI) and opposed-phase imaging (OPI) based on chemical shift artifacts. However, whether unenhanced MRI can contribute to the identification of right adrenal vein (RAV) remains unclear. The aim of this study was to evaluate the feasibility of unenhanced MRI for the identification of RAV. Material and methods: This retrospective study reviewed 30 patients (16 men; median age 60 years; range 34-76 years) who underwent MRI and subsequent adrenal venous sampling (AVS). Chemical shift MRI was acquired using echo times of 2.3 ms (OPI) and 4.6 ms (IPI) with a slice thickness of 3 mm and a gap of 1 mm. T2-weighted imaging (T2WI) was also performed. Identification of RAVs was performed by 2 independent radiologists. Inter-observer agreement on a 3-point rating scale was evaluated using κ statistics. The identification rate of RAVs was compared between OPI, IPI, and T2WI using McNemar’s test. Results: Good inter-observer agreement was found for the OPI (κ = 0.744), whereas fair agreement was obtained for both other sequences (IPI: κ = 0.375; T2WI: 0.348). For both raters, the identification rate of RAVs was higher with OPI (36/60; 60.0%) than with other sequences (IPI: 16/60, 26.7%; T2WI: 9/60, 15.0%; p < 0.05, each). Conclusions: OPI may play a screening role in the identification of RAVs preceding AVS, which could reduce the required radiation exposure and doses of contrast agent.

    DOI: 10.5114/pjr.2022.121236

    Scopus

  • Supraduodenal and right gastric arteries originating from a common trunk: a rare anatomical variant. Reviewed International journal

    @Wada N, Yamashita K, @Shin S, @Harada S, @Furuya K, @Imamura H, @Takami Y, @Noguchi T

    Jpn J Intervent Radiol.   6 ( 2 )   51 - 54   2021.6

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  • Identification of predictors for MMSE and HDS-R scores using MR-based brain morphometry Reviewed International journal

    Koji Yamashita, MD, @Takahiro Kuwashiro, @Kensuke Ishikawa, @Kiyomi Furuya, @Shino Harada, @Seitaro Shin, @Noriaki Wada, @Chika Hirakawa, @Yasushi Okada, @Tomoyuki Noguchi.

    Eur J Radiol Open.   2021.5

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    DOI: 10.1016/j.ejro.2021.100359

  • A practical system that enables physicians to respond expeditiously to significant unexpected findings (SUFs) in radiological reports. Reviewed International journal

    @Tomoyuki Noguchi, @Kumi Tanaka, @Yasushi Okada, @Kunitaka Fukuizumi, @Sachiyo Yokoda, @Motoko Dairiki, Koji Yamashita, @Seitaro Shin, @Noriaki Wada, @Shino Harada, @Shigeki Morita

    Jpn J Radiol.   2021.5

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  • Diagnostic accuracy for the epileptogenic zone detection in focal epilepsy could be higher in FDG-PET/MRI than in FDG-PET/CT Reviewed International journal

    Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Tomohiro Nakayama, Yoshiyuki Kitamura, Yoshitomo Kikuchi, Shingo Baba, Koji Sagiyama, Keisuke Ishimatsu, Ryotaro Kamei, Nobutaka Mukae, Koji Iihara, Satoshi O Suzuki, Toru Iwaki, Akio Hiwatashi

    Eur Radiol.   2021.5

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  • Vessel-selective 4D-MR angiography using superselective pseudo-continuous arterial spin labeling for the visualization of brain arteriovenous malformations. Invited Reviewed International journal

    Osamu Togao, @Makoto Obara, @Michael Helle, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Yoshitomo Kikuchi, Ataru Nishimura, Koichi Arimura, Tatsuhiro Wada, Hiroo Murazaki, Koji Iihara, @Marc Van Cauteren, Akio Hiwatashi

    Eur Radiol.   2020.12

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  • Morphology of perivascular spaces and enclosed blood vessels in young to middle-aged healthy adults at 7T: Dependences on age, brain region, and breathing gas. Reviewed International journal

    @Zong X, @Lian C, @Jimenez J. Yamashita K, @Shen D, @Lin W.

    NeuroImage.   2020.9

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    DOI: 10.1016/j.neuroimage.2020.116978.

  • Disconnection of the right superior parietal lobule from the precuneus is associated with memory impairment in oldest-old Alzheimer's disease patients Reviewed International journal

    Pukovisa Prawiroharjo, Ken-Ichiro Yamashita, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Ryo Yamasaki, Jun-Ichi Kira

    Heliyon.   2020.7

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  • A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI. Reviewed International journal

    Daichi Momosaka, Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Hirofumi Tomiyama, Tomohiro Nakao, Keitaro Murayama, @Yuriko Suzuki, Hiroshi Honda

    PLoS One.   2020.7

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  • Differentiation of high-grade from low-grade diffuse gliomas using diffusion-weighted imaging: a comparative study of mono-, bi-, and stretched-exponential diffusion models. Reviewed International journal

    Masaoki Kusunoki, Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Yoshitomo Kikuchi, Daisuke Kuga, Nobuhiro Hata, Masahiro Mizoguchi, Koji Iihara, Satoshi O Suzuki, Toru Iwaki, @Yuta Akamine, Akio Hiwatashi

    Neuroradiology.   2020.5

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  • Hippocampal Sulcus Remnant: Common Finding in Non-Elderly Adults on Ultra-High Resolution 7T MR Imaging. Reviewed International journal

    Yamashita K, @Zong X, @Hung S, @Lin W, @Castillo M.

    J Comput Assist Tomogr.   44 ( 1 )   43 - 46   2020.1

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  • Correlation between prognosis of glioblastoma and choline/N-acetyl aspartate ratio in MR spectroscopy. Reviewed International journal

    Yojiro Akagi, Naoki Noguchi, Nobuhiro Hata, Ryusuke Hatae, Yuhei Michiwaki, Yuhei Sangatsuda, Takeo Amemiya, Daisuke Kuga, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Koji Yoshimoto, Masahiro Mizoguchi, Koji Iihara

    Interdiscip Neurosurg.   2019.12

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  • Differences between Primary Central Nervous System Lymphoma and Glioblastoma: Probabilistic analysis using Voxel-based Morphometry. Reviewed International journal

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Daichi Momosaka, Hiroshi Nakatake, Nobuhiro Hata, Yojiro Akagi, Satoshi O. Suzuki, Toru Iwaki, Koji Iihara, Hiroshi Honda

    Clin Radiol.   74 ( 10 )   2019.10

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  • Acceleration-selective arterial spin labeling MR angiography for visualization of brain arteriovenous malformations. Reviewed International journal

    Osamu Togao, Akio Hiwatashi, Koji Yamashita, Daichi Momosaka, Makoto Obara, Ataru Nishimura, Koichi Arimura, Nobuhiro Hata, Koji Iihara, @Marc Van Cauteren, Hiroshi Honda

    Neuroradiology.   2019.9

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    DOI: 10.1007/s00234-019-02217-w.

  • Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 Glioblastoma. Reviewed International journal

    Koji Yamashita, Ryusuke Hatae, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Daichi Momosaka, Yasuo Yamashita, Daisuke Kuga, Nobuhiro Hata, Koji Yoshimoto, Satoshi O. Suzuki, Toru Iwaki, Koji Iihara, Hiroshi Honda

    Diagn Interv Imaging.   100 ( 7-8 )   411 - 419   2019.7

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    DOI: https://doi.org/10.1016/j.diii.2019.02.010

  • A Deep Learning Framework for Noise Component Detection from Resting-State Functional MRI. Reviewed International journal

    @Kam T, @Wen X, @Jin B, @Jiao Z, @Hsu LM, @Zhou Z, @Liu Y, Yamashita K, @Hung SC , @Lin W, @Zhang H, @Shen D, for UNC/UMN Baby Connectome Project Consortium

    MICCAI 2019.   2019.7

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  • Intravoxel Incoherent Motion Magnetic Resonance Imaging of Pediatric Intracranial Tumors: Correlation with Histology and Diagnostic Utility. Invited Reviewed International journal

    K Kikuchi, A Hiwatashi, O Togao, K Yamashita, R Kamei, D Momosaka, N Hata, K Iihara, S O Suzuki, T Iwaki, H Honda

    AJNR Am J Neuroradiol.   2019.5

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    DOI: https://doi.org/10.3174/ajnr.A6052

  • Improved Visualization of Middle Ear Cholesteatoma with Computed Diffusion-weighted Imaging. Reviewed International journal

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, @Yamato Shimomiya, Ryotaro Kamei, Daichi Momosaka, Nozomu Matsumoto, Kouji Kobayashi, @Atsushi Takemura, @Thomas Christian Kwee, @Taro Takahara, Hiroshi Honda,

    Magn Reson Med Sci   18 ( 3 )   233 - 237   2019.3

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  • Functional Connectivity Change between Posterior Cingulate Cortex and Ventral Attention Network Relates to the Impairment of Orientation for Time in Alzheimer's Disease Patients. Reviewed International journal

    Ken-Ichiro Yamashita, Taira Uehara, Pukovisa Prawiroharjo, Koji Yamashita, Osamu Togao, Akio Hiwatashi, @Yoshihide Taniwaki, @Hidetsuna Utsunomiya, Takuya Matsushita, Ryo Yamasaki, Jun-Ichi Kira

    Brain Imaging Behav.   2019.2

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  • Simultaneous MR neurography and apparent T2 mapping in brachial plexus: Evaluation of patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy Invited Reviewed International journal

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Hiroshi Nakatake, Ryo Yamasaki, Hidenori Ogata, @Masami Yoneyama, Jun-Ichi Kira, Hiroshi Honda

    Magn Reson Imaging.   2019.1

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  • Lumbar Plexus in Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Evaluation with Simultaneous T2 Mapping and Neurography Method with SHINKEI. Reviewed International journal

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Hiroshi Nakatake, Ryo Yamasaki, Hidenori Ogata, @Masami Yoneyama, Jun-Ichi Kira, Hiroshi Honda

    Br J Radiol.   2018.12

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  • Ultra-High Resolution CT Scan of the Temporal Bone. Reviewed International journal

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Nozomu Matsumoto, Daichi Momosaka, Hiroshi Nakatake, Yuki Sakai, Hiroshi Honda

    Eur Arch Otorhinolaryngol.   275 ( 11 )   2797 - 2803   2018.11

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  • 4D ASL-based MR Angiography for Visualization of Distal Arteries and Leptomeningeal Collateral Vessels in Moyamoya Disease: A Comparison of Techniques. Reviewed International journal

    Osamu Togao, Akio Hiwatashi, @Makoto Obara, Koji Yamashita, Daichi Momosaka, Ataru Nishimura, Koichi Arimura, Nobuhiro Hata, Koji Yoshimoto, Koji Iihara, @Marc Van Cauteren, Hiroshi Honda

    Eur Radiol.   2018.11

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  • Arterial spin-labeling is useful for the diagnosis of residual or recurrent meningiomas. Reviewed International journal

    Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Ryotaro Kamei, Koji Yoshimoto, Koji Iihara, Satoshi O Suzuki, Toru Iwaki, Yuriko Suzuki, Hiroshi Honda

    Eur Radiol.   2018.10

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  • A case of multiple system atrophy-parkinsonian type with stuttering- and palilalia-like dysfluencies and putaminal atrophy. Reviewed International journal

    Yoshikazu Kikuchi, Toshiro Umezaki, Taira Uehara, Hiroo Yamaguchi, Koji Yamashita, Akio Hiwatashi, Motohiro Sawatsubashi, Kazuo Adachi, Yumi Yamaguchi, Daisuke Murakami, Jun-Ichi Kira, Takashi Nakagawa

    J Fluency Disord.   2018.9

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  • Acceleration-Selective Arterial Spin Labeling MR Angiography for Visualizations of Distal Cerebral Arteries and Collateral Vessels in Moyamoya Disease. Reviewed International journal

    Osamu Togao, Hiwatashi Akio, Makoto Obara, Yamashita Koji, Ataru Nishimura, Koji Iihara, Marc Van Cauteren, Hiroshi Honda

    Radiology   2018.7

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  • Diffusion-weighted magnetic resonance imaging of extraocular muscles in patients with Grave’s ophthalmopathy using turbo field echo with diffusion-sensitized driven-equilibrium preparation. Reviewed International journal

    2018.7

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  • Qualitative and Quantitative Correlation Study of Lumbar Intervertebral Disc Degeneration Using Glycosaminoglycan Chemical Exchange Saturation Transfer, Pfirrmann Grade, and T1-ρ. Reviewed International journal

    2018.7

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  • Calcium Pyrophosphate Dihydrate Crystal Deposition Disease of the Spinal Dura Mater: A Case Report. Reviewed International journal

    BJR Case Rep.   2018.7

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  • Cerebral syphilitic gumma mimicking glioma: Utility of CT perfusion. Reviewed International journal

    Kikuchi Y, Hiwatashi A, Togao O, Yamashita K, Momosaka D, Honda H.

    Diagn Interv Imaging.   2018.6

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  • Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging: validation with histopathologic vascular density in meningiomas. Reviewed International journal

    Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Koji Yoshimoto, Daisuke Kuga, Masahiro Mizoguchi, Satoshi O Suzuki, Toru Iwaki, @Marc Van Cauteren, Koji Iihara, Hiroshi Honda

    Br J Radiol.   2018.5

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  • Usefulness of perfusion- and diffusion-weighted imaging to differentiate between pilocytic astrocytomas and high-grade gliomas: a multicenter study in Japan. Reviewed International journal

    Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Ryotaro Kamei, @Mika Kitajima, @Masafumi Kanoto, @Hiroto Takahashi, @Yusuke Uchiyama, @Masafumi Harada, @Yuki Shinohara, Takashi Yoshiura, Yuki Wakata, Hiroshi Honda

    Neuroradiology.   2018.4

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  • Structural Changes in Parkinson’s Disease. Voxel-Based Morphometry and Diffusion Tensor Imaging Analyses Based on 123I-MIBG Uptake Reviewed International journal

    2018.2

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  • Diffusivity of Intraorbital Lymphoma vs. Inflammation: Comparison of Single Shot Turbo Spin Echo and Multishot Echo Planar Imaging Techniques. Reviewed International journal

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Ryotaro Kamei, Hiroshi Yoshikawa, @Atsushi Takemura, Hiroshi Honda

    Eur Radiol.   2018.1

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  • Prevalence and clinicopathological features of H3.3 G34-mutant high-grade gliomas: a retrospective study of 411 glioma cases in a single institution. Reviewed International journal

    Brain Tumor Pathol.   2017.12

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  • High Resolution Diffusion-Weighted Imaging for Solitary Orbital Tumors: 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium (DSDE-TFE) Preparation Technique. Reviewed International journal

    Hiwatashi Akio, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, hiroshi yoshikawa, Makoto Obara, Hiroshi Honda

    Clin Neuroradiol.   2017.12

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    DOI: 10.1007/s00062-016-0556-6

  • Lumbar plexus in patients with chronic inflammatory demyelinating polyneuropathy: Evaluation with 3D nerve-sheath signal increased with inked rest-tissue rapid acquisition of relaxation enhancement imaging (3D SHINKEI) Reviewed International journal

    Eur J Radiol   93   95 - 99   2017.10

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  • Optimal Scan Timing for Artery-Vein Separation at Whole-Brain CT Angiography using a 320-Row MDCT Volume Scanner. Reviewed International journal

    Shirasaka Takashi, Hiwatashi Akio, Yamashita Koji, Masatoshi Kondo, Hiroshi Honda

    Br J Radiol.   2017.9

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  • Additive value of “Otosclerosis-weighted” images for the CT diagnosis of fenestral otosclerosis. Reviewed International journal

    2017.8

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  • Spindle cell/sclerosing rhabdomyosarcoma with intracranial invasion without destroying the bone of the skull base: A case report and literature review. Reviewed International journal

    Daichi Momosaka, Osamu Togao, Akio Hiwatashi, Koji Yamashita, Koji Yoshimoto, Megumu Mori, Toru Iwaki, Hiroshi Honda

    Acta Radiol Open.   2017.8

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  • Evaluation of chronic inflammatory demyelinating polyneuropathy: 3D nerve-sheath signal increased with inked rest-tissue rapid acquisition of relaxation enhancement imaging (3D SHINKEI). Reviewed International journal

    Hiwatashi Akio, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Masami Yoneyama, Hidenori Ogata, Ryo Yamasaki, Jun-ichi Kira, Hiroshi Honda

    Eur Radiol.   2017.3

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  • Correlation between Arterial Spin-Labeling Perfusion and Histopathologic Vascular Density of Pediatric Brain Tumors. J Neurooncol. Reviewed International journal

    Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Koji Yoshimoto, Masahiro Mizoguchi, Satoshi O Suzuki, Toru Iwaki, @Yuriko Suzuki, Hiroshi Honda

    J Neurooncol.   2017.3

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  • Cerebral Blood Flow Laterality Derived from Arterial Spin Labeling as a Biomarker for Assessing the Disease Severity of Parkinson’s Disease. Reviewed International journal

    2016.12

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  • 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium Preparation Technique (DSDE-TFE) versus Echo Planar Imaging in Evaluation of Diffusivity of Retinoblastoma. Reviewed International journal

    Hiwatashi Akio, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, hiroshi yoshikawa, Makoto Obara, Hiroshi Honda

    Br J Radiol.   2016.12

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  • Amide Proton Transfer Imaging of Brain Tumors using a Self-corrected 3D Fast Spin-Echo Dixon Method: Comparison with Separate B0 Correction. Reviewed International journal

    Osamu Togao, Keupp Jochen, Hiwatashi Akio, Yamashita Koji, Kazufumi Kikuchi, Masami Yoneyama, Hiroshi Honda

    Magn Reson Med   2016.12

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  • Primary Phosphaturic Mesenchymal Tumor of the Lumbar Spine: Utility of 68Ga-DOTATOC PET/CT Findings. Reviewed International journal

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Jyunki Maehara, Kazufumi Kikuchi, Yoshihiro Matsumoto, Yoshinao Oda, Kunio Iura, Hiroshi Honda

    BJR Case Rep.   2016.9

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  • Amide Proton Transfer Imaging of Diffuse Gliomas: Effect of Saturation Pulse length in Parallel Transmission-based Technique. Reviewed International journal

    Osamu Togao, Hiwatashi Akio, Jochen Keupp, Yamashita Koji, Kazufumi Kikuchi, Koji Sagiyama, Takashi Yoshiura, Hiroshi Honda

    PLoS One.   2016.8

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  • Diagnostic Utility of Intravoxel Incoherent Motion MR imaging in Differentiating Primary Central Nervous System Lymphoma from Glioblastoma Multiforme. Reviewed International journal

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Yoshiyuki Kitamura, Masahiro Mizoguchi, Koji Yoshimoto, DAISUKE KUGA, Satoshi O Suzuki, Shingo Baba, TAKURO ISODA, Toru Iwaki, Koji Iihara, Hiroshi Honda

    J Magn Reson Imaging.   2016.6

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  • Evaluation of Diffusivity in pituitary adenoma: 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium Preparation Reviewed International journal

    Hiwatashi Akio, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Hiroshi Honda

    Br J Radiol.   2016.6

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  • Arterial Spin-labeling in Central Nervous system Infection. Reviewed International journal

    Noguchi Tomoyuki, Yakushiji Yusuke, Masahi Nishihara, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Hiroyuki Irie

    Magn Reson Med Sci.   2016.5

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    DOI: http://doi.org/10.2463/mrms.mp.2015-0140

  • Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. Reviewed International journal

    Osamu Togao, Hiwatashi Akio, Yamashita Koji, Kazufumi Kikuchi, Jochen Keupp, Koji Yoshimoto, Satoshi O Suzuki, Koji Iihara, Hiroshi Honda

    Eur Radiol.   2016.5

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  • Prognostic utility of CT histogram analysis in patients with post-cardiac arrest syndrome: evaluation using an automated whole-brain extraction algorithm. Reviewed International journal

    Yamashita Koji, Kondo Masatoshi, Hiwatashi Akio, Osamu Togao, Kikuchi Kazufumi, Hiroshi Sugimori, Hiroshi Honda

    J Comput Assist Tomogr   2016.3

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  • Evaluation of glioblastomas and lymphomas with whole-brain CT perfusion: Comparison between a delay-invariant singular-value decomposition algorithm and a Patlak plot. Reviewed International journal

    Hiwatashi Akio, Osamu Togao, Yamashita Koji, Kikuchi Kazufumi, Koji Yoshimoto, Masahiro Mizoguchi, Satoshi O Suzuki, Hiroshi Honda

    J Neuroradiol.   2016.2

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  • Differentiation of high-grade and low-grade diffuse gliomas by intravoxel incoherent motion MR imaging. Reviewed International journal

    Osamu Togao, Hiwatashi Akio, Yamashita Koji, Kazufumi Kikuchi, Koji Yoshimoto, Satoshi O Suzuki, Hiroshi Honda

    Neuro Oncol.   18 ( 1 )   132 - 141   2016.1

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  • Histogram Analysis for Performance Assessment of Automated Extraction of Brain-Tissue Region from Whole-Brain CT Images. Reviewed International journal

    Kondo Masatoshi, Yamashita Koji, Takashi Yoshiura, Shirasaka Takashi, Arimura hisao, Nakamura Yasuhiko, Hiroshi Honda

    Springerplus   2015.12

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  • MR imaging findings of a leiomyosarcoma of the thoracic spine: A case report. Reviewed International journal

    Tahara Keiichiro, Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kikuchi Kazufumi, Makoto Endo, Hiroshi Honda

    Clin Neuroradiol.   2015.10

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  • Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors. Reviewed International journal

    Osamu Togao, Hiwatashi Akio, Keupp Jochen, Yamashita Koji, Kikuchi Kazufumi, Suzuki Yuriko, Hiroshi Honda

    J Magn Reson Imaging.   2015.5

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    DOI: 10.1002/jmri.24895.

  • Clinical significance of prenatal and postnatal heavily T2-weighted magnetic resonance images in patients with myelomeningocele. Reviewed International journal

    KIMIAKI HASHIGUCHI, Seiichi Morokuma, Hiwatashi Akio, Yamashita Koji, Koji Iihara

    Pediatric neurosurgery   2015.5

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  • 3D MR Sequence Capable of Simultaneous Image Acquisitions with and without Blood Vessel Suppression: Utility in Diagnosing Brain Metastases. Reviewed International journal

    Kazufumi Kikuchi, Hiwatashi Akio, Osamu Togao, Yamashita Koji, Masami Yoneyama, Makoto Obara, Takashi Yoshiura, Hiroshi Honda

    Eur Radiol.   2015.4

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  • Prenatal Diagnosis of Periventricular Venous Infarction in Utero. Reviewed International journal

    Yuka Otera, YASUO YUMOTO, Masayuki Ochiai, Yamashita Koji

    Case Rep. Perinat. Med.   2015.4

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  • The Radiological Diagnosis of Fenestral Otosclerosis: the Utility of Histogram Analysis using Multidetector row CT. Reviewed International journal

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Takashi inoguchi, Seiji Kumazawa, Hiroshi Honda

    Eur Arch Otorhinolaryngol.   271 ( 12 )   3277 - 3282   2014.12

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  • High-resolution three-dimensional diffusion-weighted MRI / CT image data fusion for cholesteatoma surgical planning: a feasibility study. Reviewed International journal

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Nozomu Matsumoto, Hiroshi Honda

    Eur Arch Otorhinolaryngol.   2014.12

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  • Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report. Reviewed International journal

    Ryuji Uehara, Yamashita Koji, Hiwatashi Akio, Osamu Togao, Jun Yokoyama, Dai Matsuse, Takashi Yoshiura, Hiroshi Honda

    Brain Behav.   4 ( 6 )   798 - 800   2014.11

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  • Additional MR contrast dosage for radiologists' diagnostic performance in detecting brain metastases: a systematic observer study at 3 T. Reviewed International journal

    Osamu Togao, Hiwatashi Akio, Yamashita Koji, kazufumi kikuchi, Takashi Yoshiura, Hiroshi Honda

    Jpn J Radiol.   32 ( 9 )   537 - 544   2014.9

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  • Balloon test occlusion of internal carotid artery: Angiographic findings predictive of results. Reviewed International journal

    kazufumi kikuchi, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Yamashita Koji, Hiroshi Honda

    World J Radiol.   6 ( 8 )   619 - 624   2014.8

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  • Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Reviewed International journal

    Osamu Togao, Takashi Yoshiura, Hiwatashi Akio, Yamashita Koji, Kazufumi Kikuchi, Koji Yoshimoto, Masahiro Mizoguchi, Hiroshi Honda

    Neuro Oncol.   16 ( 3 )   441 - 448   2014.3

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  • Diffusivity of intraorbital lymphoma vs. IgG4-related DISEASE: 3D turbo field echo with diffusion-sensitised driven-equilibrium preparation technique. Reviewed International journal

    Hiwatashi Akio, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Takashi Yoshiura, Hiroshi Honda

    Eur Radiol   24 ( 3 )   581 - 586   2014.3

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  • Evaluation of Diffusivity in the Anterior Lobe of the Pituitary Gland: 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium Preparation. Reviewed International journal

    Hiwatashi Akio, Takashi Yoshiura, Osamu Togao, Yamashita Koji, Hiroshi Honda, Kazufumi Kikuchi

    AJNR Am J Neuroradiol   2014.1

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  • Preoperative Evaluation and surgical Strategies for Craniocervical Junction Dural Arteriovenous Fistula with Multiple Feeders: Case report and Review of the Literature. Reviewed

    Yuichiro Kikkawa, Akira Nakamizo, Yamashita Koji

    Fukuoka Igaku Zasshi.   104 ( 9 )   299 - 308   2013.9

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  • Resolution of epidural hematoma related to osteoporotic fracture after percutaneous vertebroplasty. Reviewed International journal

    Hidenari Hirata, Hiwatashi Akio, Takashi Yoshiura, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Hiroshi Honda

    World J Radiol.   5 ( 8 )   325 - 327   2013.8

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  • Minute Subsequent Fracture at Prophylactically Treated Adjacent Vertebra After Percutaneous Vertebroplasty. Reviewed International journal

    Fumiko Kanzaki, Hiwatashi Akio, Takashi Yoshiura, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Hiroshi Honda

    Clin Neuroradiol.   2013.8

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  • Arterial spin labeling in patients with chronic cerebral artery steno-occlusive disease: correlation with 15O-PET. Reviewed International journal

    Kamano H, Yoshiura T, Hiwatashi A, Abe K, Togao O, Yamashita K, Honda H.

    Acta Radiol.   2012.10

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  • High-Resolution STIR for 3-T MRI of the Posterior Fossa: Visualization of the Lower Cranial Nerves and Arteriovenous Structures Related to Neurovascular Compression. Reviewed International journal

    Hiwatashi A, Yoshiura T, Yamashita K, Kamano H, Honda H

    AJR Am J Roentgenol.   199 ( 3 )   2012.9

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  • Arterial spin labeling of hemangioblastoma: differentiation from metastatic brain tumors based on quantitative blood flow measurement. Reviewed International journal

    Yamashita K, Yoshiura T, Hiwatashi A, Togao O, Yoshimoto K, Suzuki SO, Kikuchi K, Mizoguchi M, Iwaki T, Honda H.

    Neuroradiology   2012.8

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  • Ultrashort echo time imaging of middle ear ossicles: a feasibility study. Reviewed International journal

    Yamashita K, Yoshiura T, Hiwatashi A, Kamano H, Honda H.

    Dentomaxillofac Radiol.   2012.6

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  • Alzheimer's disease: diagnosis by different methods of voxel-based morphometry. Reviewed

    Dashjamts T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Ohyagi Y, Monji A, Kamano H, Kawashima T, Kira J, Honda H.

    Fukuoka Igaku Zasshi.   2012.3

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  • Early Findings on Brain Computed Tomography and the Prognosis of Post Cardiac Arrest Syndrome: Application of the Score for Stroke Patients. Reviewed International journal

    Sugimori H, Kanna T, Yamashita K, Kuwashiro T, Yoshiura T, Zaitsu A, Hashizume M.

    Resuscitation   2012.1

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  • Arterial spin-labeling magnetic resonance imaging: the timing of regional maximal perfusion-related signal intensity revealed by a multiphase technique. Reviewed International journal

    Noguchi T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Nagao E, Honda H.

    Jpn J Radiol.   2011.12

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  • Simultaneous arterial spin labeling cerebral blood flow and morphological assessments for detection of Alzheimer's disease. Reviewed International journal

    Dashjamts T, Yoshiura T, Hiwatashi A, Yamashita K, Monji A, Ohyagi Y, Kamano H, Kawashima T, Kira J, Honda H.

    Acad Radiol.   18 ( 12 )   2011.12

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  • Accelerated territorial arterial spin labeling based on shared rotating control acquisition: an observer study for validation. Reviewed International journal

    Kamano H, Yoshiura T, Hiwatashi A, Yamashita K, Takayama Y, Nagao E, Sagiyama K, Zimine I, Honda H.

    Neuroradiology.   2011.7

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  • Contributing Factors in the Pathogenesis of Acquired Cholesteatoma: Size Analysis Based on MDCT. Reviewed International journal

    Yamashita K, Yoshiura T, Hiwatashi A, Tuvshinjargal D, Kamano H, Shiratsuchi H, Honda H.

    AJR Am J Roentgenol.   196 ( 5 )   2011.5

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  • Three-dimensional turbo spin-echo sequence with motion-sensitized driven-equilibrium preparation for detection of brain metastases on 3-Tesla magnetic resonance image Reviewed International journal

    Nagao E, Yoshiura T, Hiwatashi A, Obara M, Yamashita K, Kamano H, Takayama Y, Kobayashi K, Honda H

    AJNR Am J Neuroradiol   32 ( 4 )   2011.4

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  • Sensorineural hearing loss: There is no correlation with isolated small lateral semicircular canal on temporal bone CT Reviewed International journal

    Yamashita K, Yoshiura T, Hiwatashi A, Dashjamts T, Kamano H, Inoguchi T, Honda H.

    Acta Radiologica   52 ( 2 )   2011.3

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  • Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis. Reviewed International journal

    Yoshiura T, Hiwatashi A, Yamashita K, Ohyagi Y, Monji A, Takayama Y, Kamano N, Kawashima T, Kira J, Honda H.

    Eur Radiol   21 ( 2 )   2011.2

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  • Volumetric Asymmetry and Differential Aging Effect of the Human Caudate Nucleus in Normal Individuals: A Prospective MR Imaging Study. Reviewed International journal

    Yamashita K, Yoshiura T, Hiwatashi A, Noguchi T, Togao O, Takayama Y, Nagao E, Kamano H, Hatakenaka M, Honda H.

    J Neuroimaging.   21 ( 1 )   2011.1

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  • Pseudoprogression following concurrent temozolomide and radiotherapy in a patient with glioblastoma: findings on functional imaging techniques. Reviewed

    Shirakawa Y, Yoshiura T, Hiwatashi A, Yamashita K, Kamano H, Shioyama Y, Abe K, Amano T, Nakamizo A, Yoshimoto K, Honda H, Torisu R, Suzuki S, Honda H.

    Fukuoka Igaku Zasshi   101 ( 12 )   2010.12

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  • Ultrashort TE MRI: Usefulness after percutaneous vertebroplasty. Reviewed International journal

    Hiwatashi A, Yoshiura T, Yamashita K, Kamano H, Honda H

    AJR Am J Roentgenol   195 ( 5 )   2010.11

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  • Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: A voxel-based morphometry study. Reviewed International journal

    Togao O, Yoshiura T, Nakao T, Nabeyama M, Sanematsu H, Nakagawa A, Noguchi T, Hiwatashi A, Yamashita K, Nagao E, Kanba S, Honda H.

    Psychiatry Res.   184 ( 1 )   2010.10

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  • Morphologic change in vertebral body after percutaneous vertebroplasty: follow-up with MDCT. AJR Am J Roentgenol Reviewed International journal

    Hiwatashi A, Yoshiura T, Yamashita K, Kamano H, Dashjamts T, Honda H.

    AJR Am J Roentgenol   195 ( 3 )   2010.9

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  • A case of giant cell glioblastoma: a mimicker of a cerebral metastasis. Reviewed

    Nagao E, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Kamano H, Mizoguchi M, Amano T, Honda H.

    Fukuoka Igaku Zasshi   101 ( 7 )   2010.7

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  • CT and MRI Findings of Human Herpesvirus 6-Associated Encephalopathy: Comparison With Findings of Herpes Simplex Virus Encephalitis. Reviewed International journal

    Noguchi T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Nagao E, Uchino A, Hasuo K, Atsumi K, Matsuura T, Kuroiwa T, Mihara F, Honda H, Kudo S.

    Am J Roentgenol.   194 ( 3 )   2010.3

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  • Intra- and interhemispheric variations of diffusivity in subcortical white matter in normal human brain Reviewed International journal

    Yoshiura T, Noguchi T, Hiwatashi A, Togao O, Yamashita K, Nagao E, Kamano H, Honda H.

    Eur Radiol.   20 ( 1 )   2010.1

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  • Asymmetrical cerebral perfusion demonstrated by noninvasive arterial spin-labeling perfusion imaging in a patient with corticobasal degeneration. Reviewed International journal

    Dashjamts T, Yoshiura T, Hiwatashi A, Yamashita K, Abe K, Ohyagi Y, Kira J, Honda H.

    Jpn J Radiol   28 ( 1 )   2010.1

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  • Subsequent Fracture after Percutaneous Vertebroplasty Can Be Predicted on Preoperative Multidetector Row CT Reviewed International journal

    Hiwatashi A, Yoshiura T, Yamashita K, Kamano H, Dashjamts T, Honda H.

    Am J Neuroradiol.   30 ( 10 )   2009.11

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  • Age-related microstructural changes in subcortical white matter during postadolescent periods in men revealed by diffusion-weighted MR imaging Reviewed International journal

    Yoshiura T, Noguchi T, Hiwatashi A, Togao O, Yamashita K, Nakao T, Nagao E, Kumazawa S, Arimura H, Honda H

    Hum Brain Mapp.   30 ( 10 )   2009.10

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  • Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease Reviewed International journal

    Yoshiura T, Hiwatashi A, Yamashita K, Ohyagi Y, Monji A, Takayama Y, Nagao E, Kamano H, Noguchi T, Honda H.

    Am J Neuroradiol   30 ( 7 )   2009.8

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  • Arterial spin labelling at 3-T MR imaging for detection of individuals with Alzheimer's disease Reviewed International journal

    Yoshiura T, Hiwatashi A, Noguchi T, Yamashita K, Ohyagi Y, Monji A, Nagao E, Kamano H, Togao O, Honda H.

    Eur Radiol.   19 ( 12 )   2009.7

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  • Kyphoplasty and Vertebroplasty Produce the Same Degree of Height Restoration Reviewed International journal

    Hiwatashi A, Westesson PL, Yoshiura T, Noguchi T, Togao O, Yamashita K, Kamano H, Honda H.

    Am J Neuroradiol.   30 ( 4 )   2009.4

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  • Early subsequent fracture after percutaneous vertebroplasty proven by magnetic resonance imaging. Reviewed International journal

    Yoshiko Tashima, Akio Hiwatashi, Takashi Yoshiura, Tomoyuki Noguchi, Osamu Togao, Koji Yamashita, Hiroshi Honda

    European Journal of Radiology Extra   68 ( 2 )   2008.12

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  • Usefulness of cone-beam CT before and after percutaneous vertebroplasty. Reviewed International journal

    Hiwatashi A, Westesson PL, Yoshiura T, Noguchi T, Togao O, Yamashita K, Kamano H, Honda H.

    Am J Roentgenol.   191 ( 5 )   2008.11

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  • MRI of glossopharyngeal neuralgia caused by neurovascular compression Reviewed International journal

    Hiwatashi A, Matsushima T, Yoshiura T, Tanaka A, Noguchi T, Togao O, Yamashita K, Honda H.

    Am J Roentgenol.   191 ( 2 )   2008.8

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  • Cortical thickness difference across the central sulcus visualized in the presence of vasogenic edema Reviewed International journal

    Togao O, Yoshiura T, Mihara F, Noguchi T, Hiwatashi A, Yamashita K, Yoshitake T, Honda H.

    Eur J Radiol.   66 ( 2 )   2008.5

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  • Perfusion imaging of brain tumors using arterial spin-labeling: correlation with histopathologic vascular density Reviewed International journal

    Noguchi T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Nagao E, Shono T, Mizoguchi M, Nagata S, Sasaki T, Suzuki SO, Iwaki T, Kobayashi K, Mihara F, Honda H.

    Am J Neuroradiol.   29 ( 4 )   2008.4

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  • Cortical damage in Alzheimer's disease estimation in medial and lateral aspects of the cerebrum using an improved mapping method based on diffusion-weighted magnetic resonance imaging Reviewed International journal

    Yoshiura T, Noguchi T, Koga H, Ohyagi Y, Hiwatashi A, Togao O, Yamashita K, Kumazawa S, Mihara F, Honda H.

    Acad Radiol   15 ( 2 )   2008.2

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  • Percutaneous vertebroplasty Reviewed

    Hiwatashi Akio, Takashi Yoshiura, Noguchi Tomoyuki, Osamu Togao, Yamashita Koji, Hiroshi Honda

    98 ( 9 )   337 - 345   2007.9

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  • Intraarterial therapy for acute ischemic stroke: investigation of prognostic factors Reviewed

    Noguchi T, Yoshiura T, Oguri S, Hiwatashi A, Togao O, Yamashita K, Nagao E, Murakami J, Mihara F, Honda H.

    Fukuoka Igaku Zasshi.   98 ( 8 )   2007.8

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  • Quantitative perfusion imaging with pulsed arterial spin labeling: a phantom study Reviewed International journal

    Noguchi T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Kobayashi K, Mihara F, Honda H.

    Magn Reson Med Sci.   6 ( 2 )   2007.2

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  • An intraorbital wooden foreign body: description of a case and a variety of CT appearances. Reviewed International journal

    Yamashita K, Noguchi T, Mihara F, Yoshiura T, Togao O, Yoshikawa H, Honda H

    Emerg Radiol.   12 ( 1 )   2007.1

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  • Cystadenoma of the liver with ovarian-like stroma: case report Reviewed International journal

    Yamashita K, Shinozaki K, Kunitake N, Matsumoto S, Matsuura H, Nakashima A.

    Abdom Imaging.   30 ( 6 )   2005.11

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  • 頭蓋内発症のCastleman病の一例

    山下孝二、松本俊一、篠崎賢治、小池真生子、國武直信、盛満人之、中島明彦

    福岡県放射線科医会誌   27   2005.8

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  • Iatrogenic injury of the internal iliac artery branch; successful coil embolization in one case Reviewed

    Yamashita K, Matasumoto S, Shinozaki K, Koike M, Kunitake N.

    Jpn J Intervent Radiol.   20 ( 3 )   2005.2

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  • 後腹膜に発症した類表皮嚢胞の一例 Reviewed

    山下孝二、宮嶋公貴、安森弘太郎、村中光、高見裕子、才津秀樹、竹下盛重

    臨床放射線   48 ( 12 )   2004.12

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▼display all

Books

  • 症例で学ぶ中枢神経の画像診断

    山下 孝二( Role: Joint author)

    金原出版  2023.4 

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    Responsible for pages:269-270, 279-280, 291-292   Language:Japanese   Book type:General book, introductory book for general audience

  • よくわかる脳MRI改訂第4版

    山下 孝二( Role: Joint author)

    秀潤社  2020.6 

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    Responsible for pages:708-709   Language:Japanese   Book type:Scholarly book

  • WHO分類による脳腫瘍のMRI

    山下 孝二, 吉浦 敬, 樋渡 昭雄, 栂尾 理( Role: Joint author)

    金原出版  2014.4 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 頭部画像診断徹頭徹尾

    山下 孝二, 吉浦 敬( Role: Joint author)

    2013.4 

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    Responsible for pages:6-14   Language:Japanese   Book type:Scholarly book

Presentations

  • Prediction of Motor Function Development in Infants Using the Thickness of the Primary Motor Cortex International conference

    Yamashita K, @Wu Z, @Zhang H, @Yin W, @Zhu Z, @Luo T, @Wen X, @Jing B, @Kam TE, @Ksu LM, @Yap PT, @Wang L, @Li G, @Li T, @Baluyot KR, @Howell BR, @Styner MA, @Yacoub E, @Chen G, @Potts T, @Gilmore JH, @Piven J, @Smith JK, @Ugurbil K, @Hazlett H, @Zhu H, @Elison JT, @Shen D, @Lin W

    25th Annual Meeting of the Organization for Human Brain Mapping  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  • Predicting IDH1 and TERT Mutation Status in the patients with Glioblastoma Invited International conference

    Yamashita Koji

    AIMS Neuro Imaging 2017  2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • MR imaging Based Analysis of Glioblastoma multiforme: Estimation of IDH1 Mutation Status International conference

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Ryusuke Hatae, Koji Yoshimoto, Masahiro Mizoguchi, Satoshi O Suzuki, Takashi Yoshiura, Hiroshi Honda

    ASNR 52th Annual Meeting & NER Foundation Symposium 2014  2014.5 

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    Event date: 2014.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • Ultrashort echo time imaging of middle ear ossicle: a pilot study. International conference

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Hironori Kamano, Yukihisa Takayama, Eiki Nagao, Hiroshi Honda

    International Society for Magnetic Resonance in Medicine  2010.5 

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    Event date: 2010.5

    Presentation type:Symposium, workshop panel (public)  

    Country:Sweden  

  • A Negative Association Between Cortical Thickness and Symmetrical Functional Connectivity Strength in the Visual Cortex During the First 2 Years of Life International conference

    Yamashita K, @Wu Z, @Yin W, @Zhu Z, @Li T, @Wang L, @Li G, @Zhu H, @Zhang H, @Lin W, and @UNC/UMN Baby Connectome Project Consortium

    106th Scientific Assembly and annual Meeting of Radiological Society of North America  2020.12 

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    Event date: 2020.11 - 2020.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Functional Development of Anteromedial Heschl’s Gyrus During Infancy Invited International conference

    2020.10 

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    Event date: 2020.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Tokyo   Country:Japan  

  • Symmetrical Functional Connectivity Strength Between Bilateral Anteromedial Heschl’s Gyri Are Negatively Associated With Receptive Function During Infancy International conference

    2019.12 

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    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chicago   Country:United States  

  • Differentiating Primary Central Nervous System Lymphoma from Glioblastoma: Probabilistic Analysis using Voxel-based Morphometry International conference

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Hiroshi honda

    ASNR 56th Annual Meeting & NER Foundation Symposium 2018  2018.6 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • Ultra-High Resolution CT Scan of the Temporal Bone International conference

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Hiroshi Honda

    ASNR 56th Annual Meeting & NER Foundation Symposium 2018  2018.6 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • Computed diffusion weighted imaging with noise reduction: Utility in diagnosing middle ear cholesteatoma International conference

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Hiroshi Honda

    103rd Scientific Assembly and annual Meeting of Radiological Society of North America  2017.11 

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    Event date: 2017.11 - 2017.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • TERT promoter mutation prediction using support vector machine (SVM) in patients with wild-type IDH1 Glioblastoma International conference

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Daichi Momosaka, Koji Yoshimoto, Hiroshi Honda

    ASNR 55th Annual Meeting & NER Foundation Symposium 2017  2017.4 

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    Event date: 2017.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Computed diffusion weighted imaging with noise reduction: improvement of contrast-to-noise ratio in middle ear cholesteatoma International conference

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Daichi Momosaka, Nozomu Matsumoto, Kouji Kobayashi, Hiroshi Honda

    2017.4 

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    Event date: 2017.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Visibility Improvement of the Artery of Adamkiewicz by High-Dose Intravenous CT Angiography: Qualitative and Quantitative Analysis International conference

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Masatoshi Kondo, Hiroshi Honda

    102nd Scientific Assembly and annual Meeting of Radiological Society of North America  2016.11 

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    Event date: 2016.11 - 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Arterial Spin Labeling as a Biomarker for the Detection of Early Stages of Parkinson’s disease International conference

    2016.5 

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    Event date: 2016.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Washington DC, USA   Country:United States  

  • Diagnostic Utility of Intravoxel Incoherent Motion MR imaging in Differentiating Primary Central Nervous System Lymphoma from Glioblastoma Multiforme International conference

    2016.4 

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    Event date: 2016.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • The Radiological Diagnosis of Fenestral Otosclerosis: the Utility of Histogram Analysis using Multidetector row CT

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Masatoshi Kondo, INOGUCHI TAKASHI, Hiroshi Honda

    101st Scientific Assembly and annual Meeting of Radiological Society of North America  2015.11 

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    Event date: 2015.11 - 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Additive value of “Otosclerosis-weighted” images for the diagnosis of fenestral otosclerosis International conference

    2015.11 

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    Event date: 2015.11 - 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chicago   Country:United States  

  • Diagnostic utility of the combination of intravoxel incoherent motion MR imaging and 18FDG-PET in differentiating primary CNS lymphoma from glioblastoma multiforme International conference

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Koji Yoshimoto, Hiroshi Honda

    10th Asian Oceanian Congress of Neuroradiology  2015.11 

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    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 脊椎原発 phosphaturic mesenchymal tumorの一例

    前原 純樹, 山下 孝二, 樋渡 昭雄, 栂尾 理, 菊地 一史, 松本 嘉寛, 本田 浩

    第181回日本医学放射線学会九州地方会  2015.7 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大分県別府市   Country:Japan  

  • T1ρ imaging in middle ear cholesteatoma International conference

    2015.6 

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    Event date: 2015.5 - 2015.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Toronto, Canada   Country:Canada  

  • 胸椎原発平滑筋肉腫の一例

    田原圭一郎, 山下 孝二, 樋渡 昭雄, 栂尾 理, 菊地 一史, 遠藤 誠, 小田 義直, 本田 浩

    第180回日本医学放射線学会九州地方会  2015.2 

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    Event date: 2015.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Prognostic value of CT histogram analysis in comatose patients: evaluation using automated whole-brain extraction algorithm International conference

    Yamashita Koji, Masatoshi Kondo, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Hiroshi Honda

    100th Scientific Assembly and annual Meeting of Radiological Society of North America:  2014.11 

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    Event date: 2014.11 - 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Prognostic utility of CT histogram analysis in post-cardiac arrest syndrome: evaluation using automated whole-brain extraction algorithm International conference

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Hiroshi Sugimori, Takashi Yoshiura, Hiroshi Honda

    KSNHNR annual meeting & neuroradiology forum-2014  2014.4 

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    Event date: 2014.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • Prognostic value of CT histogram analysis in post-cardiac arrest syndrome: evaluation using automated whole-brain extraction algorithm International conference

    Yamashita Koji, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Hiroshi Sugimori, Takashi Yoshiura, Hiroshi Honda

    2014.4 

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    Event date: 2014.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • High-resolution three-dimensional diffusion-weighted MRI / CT image data fusion for cholesteatoma surgical planning: a feasibility study International conference

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Makoto Obara, Nozomu Matsumoto, Hiroshi Honda

    99th Scientific Assembly and annual Meeting of Radiological Society of North America  2013.12 

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    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Diagnosis of otosclerosis: the utility of histogram-based analysis of multidetector row CT images International conference

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Seiji Kumazawa, Takashi Inoguchi, Hiroshi Honda

    99th Scientific Assembly and annual Meeting of Radiological Society of North America  2013.12 

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    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Usefulness of High-resolution Three-dimensional Diffusion-weighted Imaging of Middle Ear Cholesteatoma: Compared to Single-shot Echo-planar Diffusion-weighted Imaging International conference

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Kazufumi Kikuchi, Makoto Obara, Nozomu Matsumoto, Hiroshi Honda

    ASNR 51th Annual Meeting & NER Foundation Symposium 2013  2013.5 

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    Event date: 2013.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Usefulness of High-resolution Three-dimensional Diffusion-weighted Imaging of Middle Ear Cholesteatoma: Compared to Single-shot Echo-planar Diffusion-weighted Imaging International conference

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Nozomu Matsumoto, Kazufumi Kikuchi, Makoto Obara, Hiroshi Honda

    ASNR 51th Annual Meeting & NER Foundation Symposium 2013  2013.5 

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    Event date: 2013.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Additive value of arterial spin labeling in differentiating primary CNS lymphoma from glioblastoma multiforme: an observer performance study International conference

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Koji Yoshimoto, Kazufumi Kikuchi, Satoshi O Suzuki, Hiroshi Honda

    European Congress of Radiology 2013  2013.3 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Austria  

  • 高解像度三次元拡散強調画像を用いた真珠腫性中耳炎の描出:Single-shot EPI法との比較 International conference

    山下 孝二, 吉浦 敬, 樋渡 昭雄, 栂尾 理, 菊地 一史, 松本 希, 小原 真, 本田 浩

    第42回日本神経放射線学会  2013.2 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Kitakyushu   Country:Japan  

  • Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion weighted imaging, and 18F-fluorodeoxyglucose positron emission tomography International conference

    Yamashita Koji, Takashi Yoshiura, Hiwatashi Akio, Osamu Togao, Koji Yoshimoto, Masahiro Mizoguchi, Koichiro Abe, Kazufumi Kikuchi, Yasuhiro Maruoka, Hiroshi Honda

    RCNEA (Radiology Congress of North East Asia)  2012.9 

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    Event date: 2012.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion weighted imaging, and 18F-fluorodeoxyglucose positron emission tomography International conference

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Masahiro Mizoguchi, Koji Yoshimoto, Koichiro Abe, Kazufumi Kikuchi, Yasuhiro Maruoka , Hiroshi Honda

    ASNR 50th Annual Meeting & the Foundation of the ASNR Symposium 2012  2012.4 

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    Event date: 2012.4

    Presentation type:Oral presentation (general)  

    Country:United States  

  • 血管芽細胞腫と転移性脳腫瘍の鑑別:Arterial spin labeling法を用いた定量的評価

    山下 孝二 吉浦   敬 樋渡 昭雄 栂尾  理  菊地 一史 吉本 幸司 溝口 昌弘 鈴木  諭  岩城   徹 本田   浩

    第41回神経放射線学会  2012.2 

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    Event date: 2012.2

    Presentation type:Oral presentation (general)  

    Venue:三重   Country:Japan  

  • Arterial Spin Labeling of Hemangioblastoma: Differentiation from Metastatic Tumors Based on Quantitative Blood Flow Analysis International conference

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Koji Yoshimoto, Satoshi O. Suzuki, Kazufumi Kikuchi, Masahiro Mizoguchi, Toru Iwaki, Hiroshi Honda,

    ASNR 49th Annual Meeting & the Foundation of the ASNR Symposium 2011  2011.6 

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    Event date: 2011.6

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Detection of middle ear cholesteatoma by diffusion-weighted MR imaging: multi-shot EPI compared to single-shot EPI International conference

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Hironori Kamano, Tuvshinjargal Dashjamts , Shumei Shibata, Akihiro Tamae, Hiroshi Honda

    Radiological Society of North America 96th scientific assembly and annual meeting  2010.11 

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    Event date: 2010.12 - 2010.11

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Sensorineural Hearing Loss: CT Study of Lateral Semicircular Canal Morphology International conference

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Tuvshinjargal Dashjamts, Hironori Kamano, Takashi Inoguchi, Hiroshi Honda

    American Society of Neuroradiology 48th Annual Meeting  2010.5 

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    Event date: 2010.5

    Presentation type:Symposium, workshop panel (public)  

    Country:United States  

  • 馬蹄腎に発生した神経内分泌腫瘍の1例

    山崎 修司, 前原 純樹, 山下 孝二, 亀井 僚太郎, 古谷 清美, 原田 詩乃, 足達 咲紀, 野口 智幸, 坂本 直孝, 桃崎 征也

    Japanese Journal of Radiology  2024.2  (公社)日本医学放射線学会

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  • 血管炎症状を背景に非塞栓性腸間膜虚血(NOMI)を発症した1例

    山崎 修司, 前原 純樹, 山下 孝二, 亀井 僚太郎, 古谷 清美, 原田 詩乃, 野口 智幸, 宮村 知也, 坂口 義久, 河内 茂人

    Japanese Journal of Radiology  2023.2  (公社)日本医学放射線学会

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  • 画像診断レポートでの予期せぬ重大所見(SUF)に関する当院の取り組み

    野口 智幸, 山下 孝二, 進 政太郎, 和田 憲明, 原田 詩乃

    Japanese Journal of Radiology  2023.2  (公社)日本医学放射線学会

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  • 放射線レポートにおける偽陰性所見の後方視的分析(Retrospective Analysis of False-negative Findings in Radiological Reports)

    Noguchi Tomoyuki, Yamashita Koji, Kamei Ryotaro, Maehara Junki, Furuya Kiyomi, Harada Shino, Okada Yasushi

    日本医学放射線学会学術集会抄録集  2022.3  (公社)日本医学放射線学会

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  • 小脳橋角部に発生したcystic meningiomaの1例

    足達 咲紀, 山下 孝二, 古谷 清美, 原田 詩乃, 亀井 僚太郎, 前原 純樹, 野口 智幸, 宮松 雄一郎, 中溝 玲, 桃崎 征也

    Japanese Journal of Radiology  2023.2  (公社)日本医学放射線学会

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  • 基底核でのもやもや病と無症候性内頸動脈/中大脳動脈狭窄の血行動態の違い IVIM画像の有用性(Different Hemodynamic Pattern in Basal Ganglia between Moyamoya Disease and Asymptomatic Internal Carotid/M1 Stenosis using Intravoxel Incoherent Motion Imaging)

    Yamashita Koji, Noguchi Tomoyuki, Furuya Kiyomi, Harada Shino, Kamei Ryotaro, Maehara Junki

    日本医学放射線学会学術集会抄録集  2022.3  (公社)日本医学放射線学会

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  • 中枢神経 遺伝子変異時代のGliomaの診断と治療 WHO2021分類に対応したgliomaの画像診断

    山下 孝二

    Japanese Journal of Diagnostic Imaging  2023.2  日本画像医学会

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  • VISIBLEの血管描出の改善および機械学習を用いた脳転移診断の有用性の検討(Improvement of the Vessel Visibility of VISIBLE and Verifying the Usefulness of VISIBLE using Machine Learning in Detecting Brain Metastasis)

    Kikuchi Kazufumi, Togao Osamu, Yamashita Koji, Obara Makoto, Ishigami Kousei

    日本医学放射線学会学術集会抄録集  2023.3  (公社)日本医学放射線学会

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  • VETERAN法による椎骨穿刺のシミュレーション解析(A simulation analysis of vertebral puncture by the vertebral tertile area needling(VETERAN) method)

    Noguchi Tomoyuki, Yamashita Koji, Kamei Ryotaro, Maehara Junki, Harada Shino

    日本インターベンショナルラジオロジー学会雑誌  2022.5  (一社)日本インターベンショナルラジオロジー学会

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  • EPICS-DWIおよびsynthetic MR画像を用いた全脳皮質領域のADC、T1およびT2値の再現性

    山下 孝二, 栂尾 理, 米山 正己, 菊地 一史, 石神 康生

    断層映像研究会雑誌  2022.9  断層映像研究会

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  • Desmoplastic infantile gangliogliomaの1例

    菊地 一史, 石神 康生, 栂尾 理, 山下 孝二, 秦 暢宏, 吉本 幸司

    Japanese Journal of Radiology  2024.2  (公社)日本医学放射線学会

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  • COVID-19肺炎のCT所見(CT Findings of COVID-19 Pneumonia)

    Furuya Kiyomi, Nagasaki Yoji, Okamoto Masaki, Iwasaki Hiromi, Noguchi Tomoyuki, Yamashita Koji, Harada Shino, Kamei Ryotaro, Maehara Junki, Morita Shigeki

    日本医学放射線学会学術集会抄録集  2022.3  (公社)日本医学放射線学会

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  • Cerebrovascular Diseases Caused by Multisystem Disorder(タイトル和訳中)

    Yamashita Koji

    日本医学放射線学会学術集会抄録集  2024.3  (公社)日本医学放射線学会

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  • AI-VISIBLE: Utility in the Diagnosis of Brain Metastases(タイトル和訳中)

    Kikuchi Kazufumi, Togao Osamu, Yamashita Koji, Momosaka Daichi, Kikuchi Yoshitomo, Fukasawa Kazunori, Nishimura Shunsuke, Toyoda Hiroyuki, Hiwatashi Akio, Ishigami Kousei

    日本医学放射線学会学術集会抄録集  2024.3  (公社)日本医学放射線学会

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  • 'Paradoxical'cortical high-flow sign Oligodendroglioma検出の新たな指標

    山下 孝二, 栂尾 理, 菊地 一史, 空閑 太亮, 吉本 幸司, 石神 康生

    日本医学放射線学会秋季臨床大会抄録集  2022.9  (公社)日本医学放射線学会

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  • Desmoplastic infantile gangliogliomaの1例

    菊地 一史, 石神 康生, 栂尾 理, 山下 孝二, 秦 暢宏, 吉本 幸司

    Japanese Journal of Radiology  2024.2  (公社)日本医学放射線学会

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  • AI-VISIBLEを用いた脳転移診断の有用性(AI-VISIBLE: Utility in the Diagnosis of Brain Metastases)

    Kikuchi Kazufumi, Togao Osamu, Yamashita Koji, Momosaka Daichi, Kikuchi Yoshitomo, Fukasawa Kazunori, Nishimura Shunsuke, Toyoda Hiroyuki, Hiwatashi Akio, Ishigami Kousei

    日本医学放射線学会学術集会抄録集  2024.3  (公社)日本医学放射線学会

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MISC

  • Refresher Course 脳神経関連で役立つMRI撮像技術 arterial spin labeling(ASL)

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   44 ( 3 )   361 - 373   2024.2   ISSN:0285-0524

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    本稿では,ASLの原理と臨床応用について概説する.ASLは,動脈血を内因性トレーサーとして使用して脳灌流を画像化する非侵襲的手法であり,脳虚血,脳腫瘍,急性脳炎,脳症など様々な疾患の診断に有用である.また,脳血流量などの脳循環指標の定量化を行うことも可能である他,MRA技術として用いることもできる.

  • 脳腫瘍における画像診断の最前線 ―装置、撮像法など技術を中心に Reviewed

    山下 孝二, 栂尾 理, 菊地 一史, 石神 康生

    2024.1

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  • 【臨床脳腫瘍学-最新の診断・治療と病態-】脳腫瘍の検査・診断 画像診断各論 MRI 代謝画像(CEST)

    栂尾 理, 山下 孝二, 菊地 一史

    日本臨床   81 ( 増刊9 臨床脳腫瘍学 )   168 - 173   2023.12   ISSN:0047-1852

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  • 【Neuroradiology Frontier 2024 中枢神経の画像診断最前線 最先端技術で広がる臨床の可能性】脳腫瘍における画像診断技術と臨床の最前線 脳腫瘍における画像診断の最前線 装置,撮像法など技術を中心に

    山下 孝二, 栂尾 理, 菊地 一史, 石神 康生

    INNERVISION   39 ( 1 )   37 - 39   2023.12   ISSN:0913-8919

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    2021年に,WHO中枢神経系腫瘍分類第5版が出版された。最大の特徴として,組織学的所見と比べた分子遺伝学的情報の診断への寄与度が,2016年出版の改訂第4版以上に顕著となっており,腫瘍型分類にも反映されている。これは,主に分子遺伝学的所見による分類が,生命予後や治療反応性と相関することがエビデンスとして示されたことによる。画像診断学は病理組織所見との対比により発展してきたが,今回の腫瘍型分類改訂に伴い,従来の方法では術前の腫瘍型推定が困難な症例にも直面している。それでも,WHO中枢神経系腫瘍分類第5版では,発生部位,組織学的グレーディングおよび分子遺伝学的所見の組み合わせによる統合診断・層別化が重視されており,信号パターン以外にも,局在や広がりが非侵襲的に評価できる画像情報が術前診断に果たす役割は大きい。本稿では,腫瘍の縦緩和時間(T1値),横緩和時間(T2値),プロトン密度(PD)を同時取得する手法として,synthetic MRIの二次元Quantification of Relaxation Times and Proton Density by Multi-Echo acquisition of a saturation-recovery using Turbo spin-Echo Read-out(2D-QRAPMASTER)および3D-quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse(3D-QALAS)法について概説し,pseudo-3D DWI using echo planar imaging with compressed SENSE(EPICS-DWI)を用いたapparent diffusion coefficient(ADC)定量法,最後に,MR spectroscopy(MRS)を用いた分子遺伝学的所見検出の可能性について紹介する。(著者抄録)

  • 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】High-grade astrocytoma with piloid features

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生, 黒川 遼, 森谷 聡男

    画像診断   43 ( 10 )   998 - 1000   2023.8   ISSN:0285-0524

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  • 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】Diffuse hemispheric glioma, H3 G34-mutant

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   43 ( 10 )   988 - 992   2023.8   ISSN:0285-0524

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  • 経皮的椎体形成術(PVP)の現状と課題(Current status and challenges of percutaneous vertebroplasty(PVP))

    Noguchi Tomoyuki, Yamashita Koji, Kamei Ryotaro, Maehara Junki

    Japanese Journal of Radiology   41 ( 1 )   1 - 13   2023.1   ISSN:1867-1071

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  • 【Step up MRI 2022 MRI研究の最新動向&領域別MRI技術の臨床応用とトピックス】MRI研究の最新動向 Arterial spin labeling MRI技術の最新動向

    栂尾 理, 山下 孝二, 菊地 一史, 小原 真, 石神 康生

    INNERVISION   37 ( 9 )   4 - 8   2022.8   ISSN:0913-8919

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    arterial spin labeling(以下、ASL)は動脈血中のプロトンのスピンをラベルし、それを内因性トレーサーとして画像化に利用する非侵襲的手法である。近年、臨床現場では、pseudo-continuous ASL(以下、pCASL)の導入により、ASLを用いた脳灌流画像の使用が普及しつつある。臨床で用いられるASLは、通常1つのlabel duration(以下、LD)と1つのpost-labeling delay(以下、PLD)の組み合わせによる1時相での撮像であるが、ラベルされた血液がラベル面から脳組織に到達するまでの時間(arterial transit time:ATT)が長く、ラベルされた血液が到達していない場合には、正しく脳血流量(cerebral blood flow:CBF)を評価することができない。最近では、多時相撮像を行うことでATTの影響を考慮したCBFの定量化が行われるようになってきている。また、ASLは脳灌流画像のみでなく、MR angiography(以下、MRA)にも応用することができる。臨床で用いられるtime of flight(以下、TOF)-MRAは撮像スラブへのinflow効果に依存しているため、上方向以外の血流、乱流、遅い血流などの描出は不良であることや、時間情報を持っていないという欠点がある。ASLによる4D-MRAは、TOF-MRAの弱点を克服しつつ時間情報を有する画像法である。さらに、血管選択的画像も取得することができ、選択的digital subtraction angiography(以下、DSA)の代替となるような画像も得られる。本稿では、多時相ASL灌流画像とASLを用いた4D-MRAの開発の最近の動向と、それらの臨床的有用性を概説する。(著者抄録)

  • 【癌治療後の画像変化と合併症】肝細胞癌の治療後画像変化と合併症

    前原 純樹, 亀井 僚太郎, 山下 孝二, 野口 智幸, 石神 康生

    臨床放射線   67 ( 2 )   139 - 150   2022.2   ISSN:0009-9252

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    Language:Japanese   Publisher:金原出版(株)  

    <文献概要>肝細胞癌(hepatocellular carcinoma:HCC)は,放射線科医にとって因縁深い相手である。慢性肝障害の患者は頻回の画像検査を要し,新規病変を丹念に検索する必要がある。また,肝動脈化学塞栓療法(transcatheter arterial chemoembolization:TACE)により,放射線診断医が自ら癌の治療を行う疾患の一つである。HCCは,新規病変を発見することと同等以上に,治療を行った病変の画像所見や合併症の評価が重要である。2020年に免疫チェックポイント阻害薬と分子標的薬の併用療法が適応となり,HCCの治療は新たな局面を迎えている。薬物療法による治療成績が向上したことで,焼灼療法やTACE後の再発を経て薬物治療を行う例など,多様な治療内容を理解したうえで画像を評価する必要がある。本稿では,HCCに対する主な治療法について簡単に触れ,それぞれの治療後変化や合併症について解説する。

  • −脳腫瘍におけるMRI診断−神経膠腫(主に膠芽腫)におけるIDH1遺伝子変異とMRI− Reviewed

    山下 孝二、樋渡 昭雄、栂尾 理、桃坂 大地、本田 浩

    日獨医報   2018.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Arterial spin labeling

    2013.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • Japan Radiological Society

  • The Japanese Society of Neuroradiology

  • Japanese society of interventional radiology

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

  • 座長

    第197回日本医学放射線学会九州地方会  ( 那覇市 ) 2023.6

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    Type:Competition, symposium, etc. 

  • 特別講演演者

    第65回北部九州画像診断フォーラム  ( 福岡市 ) 2023.5

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    Type:Competition, symposium, etc. 

  • 座長 International contribution

    第52回日本神経放射線学会  ( 東京 ) 2023.2

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:19

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:21

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:24

  • Moderator International contribution

    ASFNR 13th Annual Meeting:  ( San Francisco, California UnitedStatesofAmerica ) 2019.11

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:13

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:6

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

  • 司会(Moderator)

    第50回北部九州画像診断フォーラム  ( 福岡市 ) 2014.11

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    Type:Competition, symposium, etc. 

  • 実行委員/プログラム委員

    第72回日本医学放射線学会総会  2012.5 - 2013.4

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    Type:Competition, symposium, etc. 

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Research Projects

  • Variable-TR法を用いた4D-ASLによる脳循環パラメータの定量的評価法の開発

    Grant number:23K07137  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    栂尾 理, 菊地 一史, 山下 孝二

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    Grant type:Scientific research funding

    本研究の目的は新たなスキームを用いた4D-ASLを開発し、それによる脳循環パラメータの定量的測定法を確立することである。
    1)ファントム実験による撮像パラメータの最適化を行う。開発したパルスシークエンスの定量性を検討するために複数のラベル時間とpost-labeling delayの組み合わせを用いて撮像を行い、それらの定量性を検討し、最適な条件を決定する。
    2)variable-TR法とtime-encoded法のハイブリッド法を健常者にて撮像し、その定量性を評価する。
    3)脳主幹動脈閉塞性疾患の患者においてハイブリッド撮像を行い、脳血流SPECTと比較し定量性を評価する。

    CiNii Research

  • 機械学習アルゴリズムを活用した加齢・変性疾患早期発見および診断指標の開発

    2022.3 - 2023.2

    個人研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 急性期脳梗塞と無症候性脳血管障害の病態解明に向けた高速MR灌流画像撮像法の開発

    Grant number:22K07657  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    山下 孝二, 野口 智幸, 杉森 宏, 桑城 貴弘, 徳永 聡

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    Authorship:Principal investigator  Grant type:Scientific research funding

    まず、短時間で撮像可能なMR灌流強調像プロトコールを開発し、プロトコールの最適化および観察者間一致率の高い解析法の構築を行う。次に、開発された撮像プロトコールを急性期脳梗塞患者に用い、虚血コアおよびペナンブラ領域の推定を行う。併行して、無症候性主幹動脈高度狭窄ないし閉塞患者の撮像を行い、開発されたプロトコールの妥当性および他の灌流強調像との相関を検討する事により、新たな脳灌流形態評価法の確立を図る。

    CiNii Research

  • A fundamental research on curation and verification methods of learning data to promote AI-CAD development

    Grant number:21K07636  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research

  • 深層学習モデルによる高分解能MRIを用いた神経疾患早期診断法の構築

    2021.1 - 2022.3

    個人研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • ラジオゲノミクス、定量的画像解析に基づく多角的な脳腫瘍診断法の開発

    Grant number:17K10365  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • MRI IVIM法を用いた脳腫瘍診断への包括的アプローチ

    2014.4 - 2017.3

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    Authorship:Principal investigator 

    MRI拡散強調像は脳腫瘍の質的診断や治療効果判定等、広く臨床的に使用されている。定量値としてみかけ上の拡散係数(ADC値)が利用されているが、実際には、現在汎用されている拡散強調像は基本的には分子拡散と毛細血管による血流(灌流)を区別する事はできない。これまで、拡散強調像は組織内の水分子拡散をターゲットに行うため灌流の影響がなるべく少なくなるようにパラメータを設定していた。しかし組織灌流はそれ自体が有用な情報であり,複数のb値を用いた拡散強調像をbi-exponential curveに近似する事で、灌流および真の拡散の両者を同時に定量するIVIM法が1980年代にLe Bihanらによって提唱された。ただ当時は、撮像時間が非常に長くなる事や大きな渦電流の影響などの問題があり、定着しなかった。近年3T MRIの普及により、拡散強調像の撮像時間は飛躍的に短縮され、非侵襲的な血流測定法として、IVIM法が最近になって再び注目されつつある。
     IVIM法はD値、D*値、f値を測定する事により組織の微小循環を定量可能であるとされるが、その生理学的な意義は解明されていない。従来の定量値測定法として、dynamic susceptibility contrast(DSC)法を用いた脳血液量測定、Arterial spin labeling(ASL)法を用いた脳血流量測定があるが、定量の際は動脈入力関数に依存し、特にASL法では脳血管障害を有する患者での定量性は疑問視されている。
    本研究の成功により、脳腫瘍診断におけるIVIM法から得られるパラメータの意義が明らかとなれば、同時取得可能な拡散情報とあわせて脳腫瘍の診断・治療法および予後推定に有用となるだけでなく、将来的な医療費抑制にも貢献する事が期待される。
    以下の3点をエンドポイントとしている。
    1.脳腫瘍診断において高い再現性を実現できる実用的なIVIM画像の撮影法の最適化を行う
    2.IVIM画像から得られる微小循環指標の生理学的な意義を明らかにする
    3.脳腫瘍診断におけるIVIM画像の有用性を明らかにする

  • MRI微小灌流・拡散定量による脳腫瘍診断への包括的アプローチ

    Grant number:26461828  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • CT/MRIフュージョン画像を用いた真珠腫性中耳炎手術診断支援システムの開発

    2011.3 - 2012.12

    個人研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 高磁場MRIを用いた微小再発真珠腫の検出法および術前診断支援システムの開発

    Grant number:23791432  2011 - 2013

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Other educational activity and Special note

  • 2023  Special Affairs 

Outline of Social Contribution and International Cooperation activities

  • 九州大学病院にて診療(外来・病棟)を行う。
    臨床研究活動の成果を国際学会にて発表。
    乳癌検診マンモグラフィーの読影。

Social Activities

  • 側頭骨領域画像診断のエッセンス

    放射線科  福岡市  2012.2

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

    側頭骨領域画像診断の概要を
    ・解剖
    ・先天異常(奇形)
    ・骨折
    ・聴神経腫瘍
    ・真珠腫性中耳炎
    に分けて解説し、最後にMRIおよびCTを用いた最近の研究について概説した。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Radiology

Clinician qualification

  • Specialist

    Japan Radiological Society(JRS)

Year of medical license acquisition

  • 2001