Updated on 2025/06/09

Information

 

写真a

 
SHIROZU KAZUHIRO
 
Organization
Kyushu University Hospital Operating Rooms Associate Professor
School of Medicine Department of Medicine（Concurrent）
Title
Associate Professor
Tel
0926425714
Profile
臨床：手術室の運営が主で、麻酔科の指導医として手術麻酔に、周術期支援センターでの術前外来に関与している。 研究：倫理審査委員会より承認を得た臨床研究（麻酔薬が瞳孔径に及ぼす影響、ROTEMを用いての周術期凝固管理,人工心肺による凝固系の変化、ECTでの瞳孔変化）、あるいは手術環境に関する研究（麻酔器搭載電動シーリングペンダントの有効性、温風式加温装置の手術室の気流変化への影響）も行っている。基礎研究では急性肝不全モデルを作成し、ファルネシルトランスフェラーゼ阻害薬であるティピファルニブの有効性の検討を取得した科研費を用いて行っている。 教育：医学部５、６年生へのベッドサイドでの講義を努め、麻酔全般の講義を担当している。また、初期研修医、後期研修医への臨床麻酔、学会発表、論文作成指導も行っている。
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Research Areas

  • Life Science / Anesthesiology

Degree

  • Doctor of Philosophy

Research History

  • Kyushu University 手術部 Associate Professor 

    2023.4 - Present

Education

  • Nagasaki University   医学部  

    - 2002.3

  • Kyushu University   九州大学大学院医学系学府機能制御医学博士課程  

    2005.4 - 2009.3

Research Interests・Research Keywords

  • Research theme： Reperfusion injury and hydrogen sulfide metabolites

    Keyword： 硫化水素

    Research period： 2023.4 - Present

  • Research theme： Estimated blood remimazolam concentration

    Keyword： レミマゾラム

    Research period： 2023.11 - Present

  • Research theme： Investigation of the effects of the intravenous anesthetic remimazolam on memory.

    Keyword： remimazolam

    Research period： 2021.4 - 2024.9

  • Research theme： Effects of pre-warming during epidural combined with　general anesthesia on body temperature reduction by induction of anesthesia

    Keyword： pre-warming, body temperature, anesthesia

    Research period： 2020.4 - 2022.4

  • Research theme： Effectiveness of circulatory management using esCCO as an index for the prevention of hypotension during cesarean section

    Keyword： cesarean section, esCCO

    Research period： 2020.4 - 2022.3

  • Research theme： The relationship between seizure in ECT and pupillary response

    Keyword： ECT

    Research period： 2016.9 - 2020.3

  • Research theme： The effect of forced air equipment on laminar flow in operating room.

    Keyword： forced air equipment, laminar flow

    Research period： 2016.7 - 2025.3

  • Research theme： The effects of colloid solution on fetal renal function.

    Keyword： colloid renal function

    Research period： 2016.7 - 2019.3

  • Research theme： The investigation of activated clotting time prolongation after cardiopulmonary bypass in open heart surgery

    Keyword： cardiopulmonary bypass

    Research period： 2016.1 - 2018.12

  • Research theme： The effect of farnesyl inhibitor on acute liver failure

    Keyword： farnesylation

    Research period： 2015.10 - 2025.3

  • Research theme： The effects of anesthetic agents on pupillary function

    Keyword： pupillary reflex

    Research period： 2015.10 - 2021.3

  • Research theme： Usability of thromboelastometry (ROTEM) for ABO-incompatible living-donor kidney transplantation

    Keyword： clotting function

    Research period： 2015.4 - 2018.12

  • Research theme： CHDF therapy

    Keyword： CHDF mesenteric artery

    Research period： 2009.4 - 2012.2

Awards

  • 第31回日本静脈麻酔学会賞(JSIVA賞)受賞

    2024.11   日本静脈麻酔学会  

    共同演者

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    Award type：Award from Japanese society, conference, symposium, etc. 

  • 第60回九州麻酔科学会最優秀演題賞受賞

    2022.9   九州麻酔科学会  

    共同演者

  • 第41回日本臨床麻酔学会最優秀演題賞受賞

    2021.11   日本臨床麻酔学会   レミマゾラムに関する研究

  • 第41回日本臨床麻酔学会企業後援研究奨励賞受賞

    2021.11   日本臨床麻酔学会   体温研究

  • 第39回日本臨床麻酔学会企業後援研究奨励賞受賞

    2019.11   日本臨床麻酔学会   体温に関する業績

  • 第56回九州麻酔科学会優秀演題賞受賞

    2018.9   九州麻酔科学会  

    共同演者

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Papers

  • Mortality and factors associated with acute exacerbation after noncardiac surgery in patients with interstitial pneumonia: a retrospective study. International journal

    Kaoru Umehara, Kazuhiro Shirozu, Taichi Ando, Kentaro Tokuda, Kei Makishima, Kazuya Imura, Shota Tsumura, Shinnosuke Takamori, Ken Yamaura

    Korean journal of anesthesiology   2025.2   （ ISSN:2005-6419 ）

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Acute exacerbation of interstitial pneumonia (AE-IP) is associated with high mortality rates. Although the risk factors for AE-IP have been extensively studied, given the small sample sizes, only a few risk factors have been established. This study aimed to investigate the postoperative mortality and factors associated with AE-IP. METHODS: This retrospective study included 482 patients with a preoperative diagnosis of IP who underwent noncardiac surgery between December 2012 and April 2020. AE-IP was diagnosed by a radiologist using computed tomography when worsening respiratory symptoms were observed within 1 month postoperatively. The Cox proportional hazards model was used to compare mortality rates. Candidate factors associated with AE-IP were identified through logistic regression analysis using the variable selection method, followed by case-control analysis using propensity score matching to determine possible factors associated with AE-IP. RESULTS: The multivariable-adjusted hazard ratios for all-cause and IP-related deaths were significantly higher in patients with AE-IP than in those without AE-IP. Multivariable analysis with variable selection suggested that male sex, higher C-reactive protein (CRP) levels, fraction of inspired oxygen (FiO2) ≥ 60%, and non-lung surgery were candidate factors associated with AE-IP. Case-control analysis using propensity score matching demonstrated that patients with AE-IP had higher CRP levels (P = 0.044) and frequency of FiO2 ≥ 60% (P = 0.035) than those without AE-IP. Furthermore, a positive, nearly linear relationship was observed between FiO2 ≥ 60% duration and AE-IP incidence. CONCLUSIONS: Intraoperative management with FiO2 ≥ 60% and high preoperative CRP levels were significantly associated with postoperative AE-IP.

    DOI： 10.4097/kja.24656

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  • Factors associated with postoperative shivering in patients with maintained core temperature after surgery. International journal

    Kazuhiro Shirozu, Masako Asada, Ryotaro Shiraki, Takuma Hashimoto, Ken Yamaura

    JA clinical reports   10 ( 1 )   70 - 70   2024.11   （ ISSN:2363-9024 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：JA Clinical Reports  

    BACKGROUND: Postoperative shivering is mainly associated with low body temperature. However, postoperative shivering can develop even at normal or high core temperatures. This study aimed to investigate the factors associated with postoperative shivering in patients with maintained core temperature after surgery. METHODS: This retrospective study involved 537 patients who had undergone radical surgery for pancreatic cancer under general anesthesia from January 2013 to December 2023. The final analysis included 441 patients whose core temperatures after surgery were ≥ 36.5℃. Logistic regression analysis was performed to estimate the odds ratio (OR) of the incidence of postoperative shivering. RESULTS: Postoperative shivering occurred in 119 patients. After multivariable-adjusted logistic regression, postoperative shivering was significantly associated with patient age (per 1 year increase; OR = 0.98; 95% confidence interval [CI]: 0.96-0.996; p = 0.02), operation time (per 30 min increase; OR = 1.10; 95% CI: 1.01-1.19; p = 0.03), postoperative core temperature (restricted cubic spline, p = 0.001), postoperative peripheral temperature (restricted cubic spline, p = 0.001), effect site fentanyl concentration at extubation (OR = 0.66; 95% CI: 0.24-0.99; p = 0.049), and acetaminophen use (OR = 0.32; 95% CI: 0.18-0.58; p < 0.001). CONCLUSIONS: Low peripheral temperature was a risk factor for the occurrence of shivering, even if the core temperature was maintained postoperatively. Peripheral temperature monitoring could be utilized to prevent postoperative shivering. In addition, fentanyl and acetaminophen reduced the occurrence of shivering in patients with maintained core temperature after surgery.

    DOI： 10.1186/s40981-024-00755-8

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  • レミマゾラムを用いた麻酔後の制吐薬使用頻度と疼痛　単施設プロポフォール対照探索的オープンランダム化臨床試験(Frequency of antiemetic use and pain after anesthesia with remimazolam: An exploratory, randomized, open, propofol-controlled, single-centre clinical trial)

    信國 桂子, 白水 和宏, 前田 愛子, 村上 智子, 東 みどり子, 山浦 健

    日本臨床麻酔学会誌   44 ( 7 )   590 - 598   2024.11   （ ISSN:0285-4945 ）

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    Language：English   Publisher：日本臨床麻酔学会  

    【目的】レミマゾラムを用いた全身麻酔からの覚醒後の制吐薬の使用頻度と疼痛について調査すること.【方法】レミマゾラムを用いた全身麻酔からの覚醒後の記憶保持を主要評価項目として検討したランダム化比較試験の副次的評価項目のデータを用いた.対象は乳房手術を受ける患者で,全身麻酔としてプロポフォール(対照群)とレミマゾラムを投与する群に無作為に割り付けられた.手術直後および病棟に戻ってから手術後24時間までの制吐薬の使用量を調査した.また,病棟に戻ってから手術後24時間までに投与された鎮痛薬の量,患者の術直後の疼痛NRS値,病棟に戻ってから手術後24時間の疼痛NRS値も検討した.【結果】全66例(プロポフォール群32例,レミマゾラム群34例)で評価した.手術直後の制吐薬使用量は両群で同等であった(p=0.43).患者が病棟に戻ってから手術後24時間までの制吐薬使用量は,プロポフォール群よリレミマゾラム群の方が有意に多かった(p=0.03).病棟に戻ってから手術後24時間までの鎮痛薬投与率(p=0.67),術直後の疼痛NRS値(p=0.74).病棟に戻ってから手術後24時間の痙痛NRS値(p=0.88)は両群で同等であった.レミマゾラム群では10例にフルマゼニルが投与された.レミマゾラム群での制吐薬の使用またはNRS値は,フルマゼニルの有無にかかわらず同程度であった.【結論】レミマゾラムの制吐薬の使用頻度を抑制する効果はプロポフォールより有意に低かった.疼痛に対する効果は両麻酔薬で同様であった.(著者抄録)

  • 類上皮肉腫の腋窩浸潤による難治性上肢痛に対して神経根高周波熱凝固法が著効した1例 Reviewed

    亀山 希, 前田 愛子, 山田 千晶, 福徳 花菜, 白水 和宏, 山浦 健

    Journal of Japan Society of Pain Clinicians   31 ( 9 )   199 - 201   2024.9   （ ISSN:13404903 eISSN:18841791 ）

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    DOI： 10.11321/jjspc.24-0032

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  • Associations between ondansetron and the incidence of postoperative nausea and vomiting and food intake in Japanese female undergoing laparoscopic gynecological surgery: a retrospective study.

    Kazuhiro Shirozu, Kaoru Umehara, Shinnosuke Takamori, Sayuri Takase, Ken Yamaura

    Journal of anesthesia   38 ( 2 )   185 - 190   2024.4   （ ISSN:0913-8668 eISSN:1438-8359 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Anesthesia  

    PURPOSE: Prevention of postoperative nausea and vomiting (PONV) is important to achieve DREAM (drinking, eating, mobilization). Ondansetron inhibits PONV, but its effects on postoperative food intake have not been investigated. This study aimed to examine associations between ondansetron and PONV incidence, and postoperative food intake. METHODS: This retrospective study included adult patients (n = 632) who underwent laparoscopic gynecological surgery at Kyushu University Hospital between January 2017 and June 2023. Outcomes were PONV on the day of surgery, PONV up to the day after surgery, and food intake, which was assessed for breakfast and lunch on the day after surgery. Odds ratios (ORs) for PONV incidence and postoperative no-food intake were calculated between those with and without ondansetron during surgery. Multivariable-adjusted analysis was performed using possible confounding factors for PONV. Synergistic effects of combining ondansetron with dexamethasone or total intravenous anesthesia (TIVA) were assessed. RESULTS: Multivariable-adjusted ORs for PONV on the day of surgery and up to the day after surgery were 0.56 (95% confidence interval, 0.32-0.99, p = 0.04) and 0.52 (0.30-0.93, p = 0.03), respectively, in the ondansetron group (n = 84) compared with the non-ondansetron group (n = 548). In contrast, multivariable-adjusted ORs for no-food intake of breakfast and lunch the day after surgery in the ondansetron group compared with the non-ondansetron group were not significant. Analysis of synergistic effects on PONV showed no significant interaction between ondansetron and dexamethasone or ondansetron and TIVA combinations. CONCLUSION: Ondansetron administration during surgery was significantly associated with decreased PONV risk but was not associated with food intake the day after surgery.

    DOI： 10.1007/s00540-023-03295-0

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  • Recovery of memory retention after anesthesia with remimazolam: an exploratory, randomized, open, propofol-controlled, single-center clinical trial. International journal

    Keiko Nobukuni, Kazuhiro Shirozu, Aiko Maeda, Kouta Funakoshi, Midoriko Higashi, Ken Yamaura

    JA clinical reports   9 ( 1 )   41 - 41   2023.7   （ ISSN:2363-9024 ）

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：JA Clinical Reports  

    PURPOSE: Remimazolam, a newly developed ultra-short-acting benzodiazepine, provides early recovery of consciousness but its effects on memory recovery are unclear. This study examined memory recovery after emergence from general anesthesia using remimazolam. METHODS: Seventy-four patients undergoing breast surgery between October 2021 and March 2022 were enrolled and randomly assigned to receive propofol (control group) or remimazolam as general anesthetic during surgery. The primary endpoint was the number of posters patients remembered 24 h after surgery (among four posters shown after recovering from anesthesia) as an assessment of memory retention. The secondary endpoints were the recall of a numeric character patients had been shown just before anesthetic induction, as an assessment of retrograde amnesia 24 h after surgery. RESULTS: Sixty-six patients (propofol, 32; remimazolam, 34) were assessed. Patients in the remimazolam group remembered significantly fewer posters shown to them after surgery than those in the propofol group (0 [0 - 2] vs. 2 [1 - 3], p < 0.001). In the remimazolam group, the patients who received flumazenil remembered a higher number of posters than those who did not receive flumazenil (3 [1 - 4] vs. 0 [0 - 0], p < 0.001). All patients remembered all events that occurred during the preoperative period as well as the numeric character. CONCLUSION: Patients recovering from remimazolam anesthesia without receiving flumazenil do not remember events after regaining consciousness. IRB: Kyushu University School of Medicine Hospital Institutional Review Board (IRB) (approval number: 20212006). TRIAL REGISTRATION: This clinical trial was registered with the University Hospital Medical Information Network (UMIN) Center on September 28, 2021 (UMIN-CTR: UMIN000045593). IMPLICATION STATEMENT: Memory recovery is slower following emergence from remimazolam than from propofol anesthesia.

    DOI： 10.1186/s40981-023-00635-7

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  • 人工膝関節置換手術後の悪心嘔吐と食事摂取量に対するオンダンセトロンの効果の検討 Reviewed

    村上　智子, 川﨑　莉佳, 福地　香穂, 趙　成三, 白水　和宏, 山浦　健

    日臨麻会誌   43 ( 4 )   290 〜296 - 296   2023.6

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    Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Effect of low dose propofol combined with remifentanil on blood pressure during modified electroconvulsive therapy: a retrospective, single-center study. Reviewed

    Eriko Shinjo, Kazuhiro Shirozu, Shinnosuke Takamori, Kaho Fukuchi, Shoko Ozasa, Atsushi Kobayashi, Sungsam Cho, Midoriko Higashi, Ken Yamaura

    循環制御   43 ( 2 )   2022.12

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • Redistributional Hypothermia Prevention by Prewarming with Forced-Air: Exploratory, Open, Randomized, Clinical Trial of Efficacy. International journal

    Kazuhiro Shirozu, Keiko Nobukuni, Jun Maki, Kanako Nagamatsu, Ryudo Tanaka, Kaiki Oya, Kouta Funakoshi, Midoriko Higashi, Ken Yamaura

    Therapeutic hypothermia and temperature management   13 ( 2 )   55 - 61   2022.8   （ ISSN:2153-7658 eISSN:2153-7933 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Therapeutic Hypothermia and Temperature Management  

    Avoiding redistributional hypothermia that decreases core temperature by 0.5-1.5°C within the 1st hour of surgery is difficult. The efficacy of prewarming using a forced-air warming (FAW) device with a lower-body blanket on redistribution hypothermia during epidural procedures have not been investigated. After ethics approval, 113 patients undergoing laparoscopic surgery under general anesthesia combined with epidural anesthesia were enrolled. Intervention (prewarming) group patients who were warmed from operating room entry, including during epidural anesthesia, was compared with the control group that was warmed from just before surgery started. In total, 104 patients (52, control; 52, prewarming) were analyzed. In the prewarming group, compared to the control group, the core temperature 20 minutes after anesthesia induction (36.9 ± 0.4 vs. 37.1 ± 0.4°C, p < 0.02) was significantly higher. The core temperature was higher in the prewarming group than in the control group until 3 hours after the surgery. In the prewarming group, compared to the control group, the core temperature-time integral below baseline till 180 minutes after surgery start (65.1 ± 64.0 vs. 8.1 ± 18.6°C/min, p < 0.0001) or 30 minutes after anesthesia induction (5.3 ± 6.2 vs. 2.0 ± 4.7°C/min, p < 0.0001) were significantly smaller. Postoperative shivering was comparable between the groups. Prewarming during epidural catheter insertion with a FAW device could safely prevent a core temperature decrease induced by redistribution or heat loss without additional preparation, effort, space, or time requirements.

    DOI： 10.1089/ther.2022.0009

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  • Lower-Leg Amputation Performed Under Regional Anesthesia in a Patient with Epidermolysis Bullosa: A Case Report. International journal

    Yuka Inoue, Kazuhiro Shirozu, Ryotaro Shiraki, Tetsuhiro Fujiyoshi, Kana Fukutoku, Yukie Mizuta, Midoriko Higashi, Ken Yamaura

    The American journal of case reports   23   e936722   2022.7   （ eISSN:1941-5923 ）

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Journal of Case Reports  

    BACKGROUND Epidermolysis bullosa (EB) is a group of rare genetic conditions that can cause eruption of blisters on the skin and mucous membranes by the slightest mechanical stimulus. In these patients particular attention should be paid to potential complications, from monitoring of vital signs to anesthesia procedures in the perioperative period. CASE REPORT A 31-year-old man with EB underwent lower-leg amputation for squamous cell carcinoma. Multiple blisters and scars had appeared all over his face and body, and his extremities were contracted. The patient's mouth could open only up to approximately 5 mm, and laboratory examination showed a high inflammatory response. In addition, he had anemia and hypoalbuminemia with a serum albumin concentration of 1.4 g/dL. We planned sciatic and femoral nerve blocks with sedation for anesthesia management because of the anticipated difficulty of intubation and concern about postoperative upper-airway obstruction due to changes in the oral cavity. While protecting the skin from external force application, we performed sciatic and femoral nerve blocks (1.7 mg/kg) using 0.25% levobupivacaine, 10 mL (3.5 mg/kg) of 1% mepivacaine, and 6.6 mg of dexamethasone. Good analgesia was achieved, and the patient was stable during the operation. The patient was discharged 12 days postoperatively without additional signs of infection or new blister formation, although surgical wound healing was delayed. CONCLUSIONS For patients with EB who have had repeated blistering and scarring, even from a minor external force, attention should be paid to airway management and avoidance of additional skin damage caused by external forces.

    DOI： 10.12659/AJCR.936722

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  • Comparison of the Occurrence of Postoperative Shivering Between Sevoflurane and Desflurane Anesthesia. Reviewed International journal

    Kazuhiro Shirozu, Keiko Nobukuni, Kaoru Umehara, Masako Nagamatsu, Midoriko Higashi, Ken Yamaura

    Therapeutic hypothermia and temperature management   12 ( 3 )   177 - 181   2022.1   （ ISSN:2153-7658 eISSN:2153-7933 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Therapeutic Hypothermia and Temperature Management  

    General anesthetic agents can change the shivering threshold. Sevoflurane and desflurane are widely used as inhalational anesthetics and have also been reported to lower the shivering threshold in a dose-dependent manner. Although the comparison of postoperative shivering (POS) between total intravenous anesthesia and inhalational anesthesia has been reported, there have been no reports on a direct comparison between sevoflurane and desflurane anesthesia and the occurrence of POS in open abdominal surgery. After obtaining approval from the Ethics Review Committee (2020-261), 683 adult patients who underwent open radical surgery for uterine, cervical, or pancreatic cancer under general anesthesia using inhalational anesthetics at Kyushu University hospital between December 2012 and March 2020 were included in this retrospective study. The odds ratio (OR) for the occurrence of POS between the two groups (sevoflurane and desflurane) was calculated. Multivariable-adjusted analysis was performed using possible factors affecting POS. Furthermore, propensity score (PS) matching was conducted using these factors. The multivariable-adjusted OR for the occurrence of shivering in the desflurane group (62 occurrences/356 patients) was 1.06 (95% confidence interval [CI]: 0.69-1.62, p = 0.79) compared with the sevoflurane group (77/327, reference). Similarly, after PS matching, the crude OR for the occurrence of shivering in the desflurane group (47/210) was 1.09 (95% CI: 0.68-1.75, p = 0.72) compared with the sevoflurane group (44/210, reference). Similar results were obtained in the stratified analysis by sex and age. The occurrence of POS is not different between sevoflurane and desflurane anesthesia.

    DOI： 10.1089/ther.2021.0029

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  • Neurological sedative indicators during general anesthesia with remimazolam. Reviewed

    Kazuhiro Shirozu, Keiko Nobukuni, Shota Tsumura, Kazuya Imura, Kosuke Nakashima, Shinnosuke Takamori, Midoriko Higashi, Ken Yamaura

    Journal of anesthesia   36 ( 2 )   194 - 200   2022.1   （ ISSN:0913-8668 eISSN:1438-8359 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Anesthesia  

    BACKGROUND: The bispectral index (BIS) value during general anesthesia with the newly developed anesthetic remimazolam is reported to be relatively high; however, the reason for this and the appropriate indicator for assessing the sedation level during remimazolam anesthesia have not been determined. In this study, the level of sedation during general anesthesia with remimazolam was evaluated using several different indicators. METHODS: Thirty patients who underwent breast surgery under general anesthesia with remimazolam were included. BIS®, Sedline® and the pupil resting diameters were measured simultaneously. The intraoperative dose of remimazolam was adjusted to obtain a BIS in the range of 40-60; if a BIS < 60 could not be achieved, the intraoperative dose was increased up to the maximal dose of 2 mg/kg/h. RESULTS: The mean intraoperative BIS and patient state index (PSI) in all patients was 50.6 ± 9.1 and 43.0 ± 11.8, respectively. Five patients showed a mean intraoperative BIS > 60 and eight patients showed mean intraoperative PSI > 50. The mean intraoperative spectral edge frequency (SEF) of BIS® or Sedline® was 15.3 ± 2.5 Hz or 10.6 ± 3.0 Hz, each. The mean intraoperative resting pupil diameter was 1.7 ± 0.2 mm. There were no patients with awareness during anesthesia. CONCLUSIONS: Processed electroencephalograms (BIS and PSI), and SEF of BIS® were relatively high during anesthesia with remimazolam, but SEF of Sedline® or pupillary diameter could be a supportive indicator to confirm sedation level during remimazolam anesthesia.

    DOI： 10.1007/s00540-021-03030-7

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  • The effect of remimazolam on postoperative memory retention and delayed regeneration in breast surgery patients: Rationale and design of an exploratory, randomized, open, propofol-controlled, single-center clinical trial: A study protocol. International journal

    Kazuhiro Shirozu, Keiko Nobukuni, Kouta Funakoshi, Taizo Nakamura, Makoto Sumie, Midoriko Higashi, Ken Yamaura

    Medicine   100 ( 48 )   e27808   2021.12

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/MD.0000000000027808

  • Association of an electromyographic tube for severe postoperative laryngeal edema and reintubation in neurosurgery: a retrospective study.

    Hiroki Matsushita, Kazuhiro Shirozu, Kaoru Umehara, Kenji Uehara, Makoto Takatori, Ken Yamaura

    Journal of anesthesia   35 ( 5 )   611 - 616   2021.10

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    DOI： 10.1007/s00540-021-02953-5

  • Association between ionized magnesium and postoperative shivering.

    Tetsuzo Nakayama, Kaoru Umehara, Kazuhiro Shirozu, Makoto Sumie, Yuji Karashima, Midoriko Higashi, Ken Yamaura

    Journal of anesthesia   35 ( 3 )   412 - 419   2021.6

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    DOI： 10.1007/s00540-021-02914-y

  • Intubation Technique in a Patient with Tracheobronchopathia Osteochondroplastica. International journal

    Ryoko Takamori, Kazuhiro Shirozu, Ryosuke Hamachi, Kiyokazu Abe, Shoko Nakayama, Ken Yamaura

    The American journal of case reports   22   e928743   2021.1

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    DOI： 10.12659/AJCR.928743

  • Effects of forced air warming systems on the airflow and sanitation quality of operating rooms with non-laminar airflow systems Reviewed

    Kazuhiro Shirozu, Shinnosuke Takamori, Hidekazu Setoguchi, Ken Yamaura

    Perioperative Care and Operating Room Management   21   2020.12

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    DOI： 10.1016/j.pcorm.2020.100119

  • Evaluation of postoperative kidney function after administration of 6% hydroxyethyl starch during living-donor nephrectomy for transplantation Reviewed International journal

    Kazuhiro Shirozu, Kaoru Umehara, Masatsugu Watanabe, Akihiro Tsuchimoto, Yasuhiro Okabe, Ken Yamaura

    Journal of Anesthesia   2020.10

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    DOI： 10.1007/s00540-020-02862-z

  • Effect of antithrombin in fresh frozen plasma on hemostasis after cardiopulmonary bypass surgery Reviewed

    Kazuhiro Shirozu, Yuji Karashima, Ken Yamaura

    Perfusion   267659120948435   2020.8

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    DOI： 10.1177/0267659120948435

  • Impact of air-conditioner outlet layout on the upward airflow induced by forced air warming in operating rooms Reviewed

    Kazuhiro Shirozu, Hidekazu Setoguchi, Kenzo Araki, Taichi Ando, Ken Yamaura

    American Journal of Infection Control   2020.8

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    DOI： 10.1016/j.ajic.2020.06.202

  • The farnesyltransferase inhibitor tipifarnib protects against autoimmune hepatitis induced by Concanavalin A Reviewed

    Jie Guo, Kazuhiro Shirozu, Tomohiko Akahoshi, Yukie Mizuta, Masaharu Murata, Ken Yamaura

    International Immunopharmacology   83   2020.6

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    DOI： 10.1016/j.intimp.2020.106462

  • Incidence of postoperative shivering decreased with the use of acetaminophen a propensity score matching analysis Reviewed

    Kazuhiro Shirozu, Kaoru Umehara, Mizuko Ikeda, Yutaro Kammura, Ken Yamaura

    Journal of Anesthesia   2020.6

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    DOI： 10.1007/s00540-020-02763-1

  • Cerebral infarction detected after laparoscopic partial hepatectomy case report Reviewed International journal

    Atsushi Kobayashi, Kazuhiro Shirozu, Yuji Karashima, Katsuyuki Matsushita, Ken Yamaura

    JA Clinical Reports   5 ( 1 )   82   2019.12

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    DOI： 10.1186/s40981-019-0301-7

  • Required time for setting up an anaesthesia machine mounted on a movable ceiling pendant Reviewed

    Kazuhiro Shirozu, Tetsuya Kai, Mizuho Fukumoto, Kumiko Ippoushi, Hidekazu Setoguchi, Sumio Hoka

    Journal of Perioperative Practice   29 ( 7-8 )   237 - 241   2019.7

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    DOI： 10.1177/1750458918798565

  • Pupillary response as assessment of effective seizure induction by electroconvulsive therapy Reviewed

    Kazuhiro Shirozu, Keitaro Murayama, Ken Yamaura

    Journal of Visualized Experiments   2019 ( 146 )   2019.4

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    DOI： 10.3791/59488

  • The relationship between seizure in electroconvulsive therapy and pupillary response using an automated pupilometer Reviewed

    Kazuhiro Shirozu, Keitaro Murayama, Yuji Karashima, Hidekazu Setoguchi, Tomofumi Miura, Sumio Hoka

    Journal of Anesthesia   32 ( 6 )   866 - 871   2018.12

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    DOI： 10.1007/s00540-018-2566-9

  • A case of sudden decreases in oxygen saturation and blood pressure during and after osteosynthesis Reviewed

    Aya Yoshidome, Kazuhiro Shirozu, Jun Maki, Yuji Karashima, Sumio Hoka

    Japanese Journal of Anesthesiology   67 ( 7 )   758 - 761   2018.7

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  • 術中体位により腕神経叢損傷を生じた症例 Reviewed

    田原康次郎、白水和宏、門田英輝、島内司、辛島裕士、外須美夫

    日本臨床麻酔学会誌   2018.7

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  • Effects of preoperative plasma exchange therapy with albumin replacement fluid on blood coagulation in patients undergoing ABO-incompatible living-donor kidney transplantation using rotational thromboelastometry Reviewed

    Kazuhiro Shirozu, Naoyuki Fujimura, Yuji Karashima, Mizuko Ikeda, Hidehisa Kitada, Yasuhiro Okabe, Kei Kurihara, Tomoko Henzan, Sumio Hoka

    BMC anesthesiology   18 ( 1 )   2018.6

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    DOI： 10.1186/s12871-018-0536-2

  • Incidental cerebral acute subdural hematoma after transforaminal lumbar interbody fusion A case report

    Kazuhiro Shirozu, Keita Takahashi, Mitsumasa Hayashida, Katsuyuki Matsushita, Yasuharu Nakashima, Sumio Hoka

    100 Selected Case Reports from Anesthesia and Analgesia   2018.1

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    DOI： 10.1213/XAA.0000000000000536

  • 確定診断のための生検術後に長期間呼吸管理を要した縦隔リンパ管腫症の1例 Reviewed

    河野 裕美, 白水 和宏, 宗崎 良太, 辛島 裕士, 田口 智章, 外 須美夫

    日本臨床麻酔学会誌   38 ( 1 )   30 - 35   2018.1

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    DOI： https://doi.org/10.2199/jjsca.38.30

  • Effects of Forced Air Warming on Airflow around the Operating Table Reviewed

    Kazuhiro Shirozu, Tetsuya Kai, Hidekazu Setoguchi, Nobuyasu Ayagaki, Sumio Hoka

    Anesthesiology   128 ( 1 )   79 - 84   2018.1

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    DOI： 10.1097/ALN.0000000000001929

  • Esophageal submucosal hematoma possibly caused by gastric tube insertion under general anesthesia

    Yuri Fujimoto, Kazuhiro Shirozu, Noritoshi Shirozu, kozaburo akiyoshi, ataru nishimura, Sho Kawasaki, Yoshimasa Motoyama, Tadashi Kandabashi, Koji Iihara, Sumio Hoka

    100 Selected Case Reports from Anesthesia and Analgesia   2018.1

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    DOI： 10.1213/XAA.0000000000000376

  • 傍脊椎ブロック施行後に一過性の対麻痺を来した一症例 Reviewed

    川副明生、荒木建三、白水和宏、松下克之、信國桂子、添田祐治、辛島裕士、外須美夫

    麻酔   66 ( 12 )   1308 - 1311   2017.12

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  • 当院における準備血液製剤の過不足状況とその管理 Invited Reviewed

    白水　和宏, 山口　恭子, 青木　香苗, 久保田　諒, 瀨戸口 秀一, 外 須美夫

    日本手術医学会誌   38 ( 2 )   57 - 61   2017.6

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  • Hematoma After Transversus Abdominis Plane Block in a Patient With HELLP Syndrome A Case Report Reviewed

    Kazuhiro Shirozu, Sumiko Kuramoto, Saki Kido, Kengo Hayamizu, Yuji Karashima, Sumio Hoka

    A & A case reports   8 ( 10 )   257 - 260   2017.5

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    DOI： 10.1213/XAA.0000000000000487

  • The effects of anesthetic agents on pupillary function during general anesthesia using the automated infrared quantitative pupillometer Reviewed

    Kazuhiro Shirozu, Hidekazu Setoguchi, Kentaro Tokuda, Yuji Karashima, Mizuko Ikeda, Makoto Kubo, Katsuya Nakamura, Sumio Hoka

    Journal of Clinical Monitoring and Computing   31 ( 2 )   291 - 296   2017.4

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    DOI： 10.1007/s10877-016-9839-3

  • The effects of tramadol on postoperative shivering after sevoflurane and remifentanil anesthesia Reviewed

    Taku Nakagawa, Miki Hashimoto, Yasunori Hashimoto, Kazuhiro Shirozu, Sumio Hoka

    BMC anesthesiology   17 ( 1 )   2017.1

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    DOI： 10.1186/s12871-016-0295-x

  • 先天性高インスリン血症患児に対する膵頭部切除術の麻酔経験 Reviewed

    小野　雄介, 水田　幸恵, 河﨑　翔, 白水　和宏, 辛島 裕士, 外 須美夫

    日本臨床麻酔学会誌   ３６ ( ３ )   ２８６ - ２９０   2016.5

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  • 声門上デバイス (air-Q(R)) 下に気管内異物を摘出した小児の1症例 Invited Reviewed International journal

    竹内　愛美, 田口　祥子, 田中　万里子, 白水　和宏, 辛島 裕士, 外 須美夫

    日本臨床麻酔学会誌   36 ( 2 )   158 - 162   2016.3

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  • Farnesyltransferase inhibitor, tipifarnib, prevents galactosamine/lipopolysaccharide-induced acute liver failure Reviewed

    Kazuhiro Shirozu, Shuichi Hirai, Tomokazu Tanaka, Shinsuke Hisaka, Masao Kaneki, Fumito Ichinose

    Shock   42 ( 6 )   570 - 577   2014.12

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    DOI： 10.1097/SHK.0000000000000239

  • Cystathionine γ-Lyase deficiency protects mice from Galactosamine/lipopolysaccharide-induced acute liver failure Reviewed

    Kazuhiro Shirozu, Kentaro Tokuda, Eizo Marutani, David Lefer, Rui Wang, Fumito Ichinose

    Antioxidants and Redox Signaling   20 ( 2 )   204 - 216   2014.1

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    DOI： 10.1089/ars.2013.5354

  • 急性腎不全患者に対する持続的血液濾過透析におけるポリスルホン膜とポリメチルメタクリレート膜との有効性の比較 Reviewed

    白水 和宏, 杉森 宏, 藤吉 哲宏, 坂口 嘉郎, 橋爪 誠

    日本集中治療医学会雑誌   2012.4

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  • SERVO-i でのBi-Vent モードの使用経験 Invited

    白水 和宏

    人工呼吸   2011.5

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  • 気管分岐部腫瘍切除術の麻酔経験 Reviewed

    白水和宏、赤田　隆、辛島裕士、外　須美夫

    臨床麻酔   ( 34 )   2010.10

  • The mechanisms of the direct action of etomidate on vascular reactivity in rat mesenteric resistance arteries Reviewed

    Kazuhiro Shirozu, Takashi Akata, Jun Yoshino, Hidekazu Setoguchi, Keiko Morikawa, Sumio Hoka

    Anesthesia and Analgesia   108 ( 2 )   496 - 507   2009.2

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    DOI： 10.1213/ane.0b013e3181902826

  • Anesthetic management for transcatheter pulmonary valve implantation

    Ando Taichi, Shirozu Kazuhiro, Ozasa Shoko, Karashima Yuji, Yamaura Ken

    Cardiovascular Anesthesia   28 ( 1 )   119 - 123   2024.9   （ ISSN:13429132 eISSN:18847439 ）

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    <p>　Significant pulmonary valve regurgitation after congenital heart disease surgery in adults is being observed increasingly. Since 2010, transcatheter pulmonary valve implantation (TPVI) is being performed in the United States in patients with a history of multiple operations, who are considered at high risk for open heart surgery. The Harmony? Transcatheter Pulmonary Valve System (Medtronic Japan, Inc., [Harmony TPV]) was introduced into clinical practice in Japan in March 2023. It is a transcatheter implantation system that uses a porcine pericardial bioprosthetic valve attached to a self-expandable nitinol frame. Transcatheter implantation of the device is performed using a biplane X-ray angiography system. Although TPVI is minimally invasive, the caveats associated with this approach include the need for nonoperating room anesthesia management, complications attributable to poor surgical skill, procedure-related arrhythmias, and circulatory instability during valve deployment.</p><p>In this report, we describe our experience with anesthesia management in two cases of TPVI.</p>

    DOI： 10.11478/jscva.2023-3-014

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  • Anesthetic management in pregnant women with Fontan circulation: a case series. International journal

    Ai Fujita, Kazuhiro Shirozu, Midoriko Higashi, Ken Yamaura

    JA clinical reports   10 ( 1 )   25 - 25   2024.4   （ ISSN:2363-9024 ）

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    BACKGROUND: Given the advances in medicine, women with Fontan circulation are now reaching childbearing age. However, data on the mode of delivery and anesthetic management of these patients are limited. We report the cases of five pregnant women with Fontan circulation. CASE PRESENTATION: The mean age at delivery was 28 ± 3 years, and the mean gestational period was 34 weeks and 3 days. Anticoagulation therapy was switched from warfarin and aspirin to continuous intravenous heparin. The modes of delivery were scheduled cesarean section (C/S) in one, emergency C/S in three, and vaginal delivery with epidural labor analgesia in one patient. Three patients underwent C/S under regional anesthesia; one received general anesthesia. The perinatal complications were heart failure, worsening valve regurgitation, and postoperative hematoma in three, four, and two patients, respectively. CONCLUSIONS: For C/S in women with Fontan circulation, regional anesthesia should be considered. Epidural labor analgesia can help prevent the decrease in pulmonary blood flow due to straining. We initiated labor analgesia or C/S with regional anesthesia at the appropriate time in four patients.

    DOI： 10.1186/s40981-024-00706-3

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  • 脊髄くも膜下硬膜外併用麻酔下でのデクスメデトミジンからの覚醒中にBezold-Jarisch反射による高度徐脈が出現した症例　1症例報告(Severe bradycardia due to Bezold-Jarisch reflex occurred during arousal from dexmedetomidine under spinal and epidural anesthesia: Case report)

    Mizuta Yukie, Daikaku Takafumi, Fujiyoshi Tetsuhiro, Matsushita Katsuyuki, Shirozu Kazuhiro, Higashi Midoriko, Yamaura Ken

    循環制御   44 ( 2 )   99 - 102   2023.12   （ ISSN:0389-1844 ）

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    症例は60歳女性で、高血圧症であり、発達性股関節形成不全のため右人工股関節置換術(THA)を計画していた。術前の心電図で異常はみられず、麻酔前の血圧は178/101mmHg、心拍数は65bpmであった。脊髄くも膜下硬膜外併用麻酔として、デクスメデトミジン(DEX)6μg/kg/時を10分間かけて注入し、続いて鎮静のために0.4μg/kg/時を持続投与した。その後、血圧は103/60mmHg、心拍数は50bpmにそれぞれ低下した。手術がほぼ終了した時点でDEX注入を中止し、レボブピバカイン0.125%を4mL/時で持続硬膜外麻酔を開始した。その際、患者は覚醒時に肩の痛みを経験した。DEX中止から3分後、心拍数が10bpmに突然低下し、意識を失った。アトロピン0.5mgを2回静注した結果、心拍は正常な洞調律に戻り、意識を取り戻した。その後、バイタルサインは安定し、手術は終了した。手術時間は96分、麻酔時間は132分であった。この高度徐脈は、Bezold-Jarisch反射が一因であると考えられた。

  • Effect of Ondansetron on Postoperative Nausea and Vomiting and Food Intake after Knee Arthroplasty

    MURAKAMI Tomoko, KAWASAKI Rika, FUKUCHI Kaho, CHO Sungsam, SHIROZU Kazuhiro, YAMAURA Ken

    THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA   43 ( 4 )   290 - 296   2023.7   （ ISSN:02854945 eISSN:13499149 ）

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    <p>Patients who underwent knee arthroplasty under general anesthesia were evaluated for the incidence of postoperative nausea and vomiting（PONV）and food intake in a retrospective observational study. They were divided into two groups：30 patients who received ondansetron at the end of surgery（ONDA group）and 29 patients who did not receive ondansetron（CONT group）. The incidence of PONV, antiemetic drug use, and iv-PCA discontinuation rate were all significantly lower in the ONDA group. Mean food intake up to the first postoperative day was significantly higher in the ONDA group and significantly lower in the group with PONV than in the group without PONV. These results suggest that Ondansetron can be effective in the treatment of PONV and food intake after knee arthroplasty.</p>

    DOI： 10.2199/jjsca.43.290

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  • Safety and utility of ultrasound-guided superior cervical ganglion block for headaches and orofacial pain: a retrospective, single-center study of 10 patients. International journal

    Aiko Maeda, Yoji Chikama, Ryudo Tanaka, Masachika Tominaga, Kazuhiro Shirozu, Ken Yamaura

    JA clinical reports   9 ( 1 )   21 - 21   2023.4   （ ISSN:2363-9024 ）

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    BACKGROUND: Several new ultrasound-guided superior cervical ganglia blocks (U-SCGBs) have been proposed to overcome the shortcomings of conventional superior cervical ganglia blocks; however, their clinical utility and practicality have not yet been demonstrated. The aim of this study was to evaluate the safety and utility of a new method of U-SCGB. METHODS: We retrospectively collected data on patients who underwent U-SCGB for the treatment of headaches and orofacial pain at a single center. U-SCGB was performed by injecting 2-3 mL of 1% mepivacaine posterior to the internal carotid artery, just above the bifurcation. The Wilcoxon signed-rank test was used to compare pain scores. Numerical data are expressed as the mean ± standard error. RESULTS: The total number of U-SCGB procedures was 43. All procedures were accompanied by Horner's sign. The numerical rating scale score for pain (possible scores, 0-10) was reduced predominantly from 7.0 ± 0.7 before treatment to 4.5 ± 0.7 at the follow-up (p = 0.014). CONCLUSION: U-SCGB was considered a clinically useful and accurate treatment for headaches and orofacial pain in this study.

    DOI： 10.1186/s40981-023-00613-z

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  • A Case of Psychogenic Non-Epileptic Seizure after Awakening from General Anesthesia：A Case Report

    NAGAMATSU Kanako, CHO Sungsam, SHIROZU Kazuhiro, YAMAURA Ken

    THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA   43 ( 1 )   10 - 15   2023.1   （ ISSN:02854945 eISSN:13499149 ）

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    <p>We experienced a case of psychogenic non-epileptic seizure（PNES）after awakening from general anesthesia. The patient was a 34-year-old woman. Two hours after returning to the room from an orthopedic surgery under general anesthesia, she developed generalized seizures. Diazepam was administered, and 20 minutes later the convulsions subsided, but she continued to have upper body dominant convulsions for 1 to 3 minutes. There were no neurological abnormalities other than convulsions, and no abnormalities on head imaging examination.</p><p>An electroencephalogram（EEG）examination revealed no epileptic waves during the seizures, and the EEG was always awake, leading to the diagnosis of PNES. When seizures are observed, it is necessary to carefully diagnose and treat them by searching for the cause in parallel with the treatment, and if treatment-resistant seizures persist, PNES should be considered.</p>

    DOI： 10.2199/jjsca.43.10

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  • Severe bradycardia due to Bezold-Jarisch reflex occurred during arousal from dexmedetomidine under spinal and epidural anesthesia: Case report Reviewed

    Mizuta Yukie, Daikaku Takafumi, Fujiyoshi Tetsuhiro, Matsushita Katsuyuki, Shirozu Kazuhiro, Higashi Midoriko, Yamaura Ken

    CIRCULATION CONTROL   44 ( 2 )   99 - 102   2023   （ ISSN:03891844 ）

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     Severe bradycardia and hypotension during arousal from sedation with dexmedetomidine in a patient with combined spinal and epidural anesthesia is rare. We present a case of a 60-year-old woman who underwent total hip arthroplasty (THA) under combined spinal and epidural anesthesia (CSEA). Severe bradycardia (10 bpm) and hypotension were developed at arousal from sedation with dexmedetomidine prior to the end of the surgery. At that time, she complained of shoulder pain. Cardiac rhythm was restored by the administration of atropine. She was not under high spinal anesthesia. This severe bradycardia was mainly attributed to Bezold-Jarisch reflex (BJR) with decreased preload due to the low concentration of dexmedetomidine and increased inotropic state because of severe pain. BJR may develop during arousal from sedation with dexmedetomidine under combined spinal and epidural anesthesia.

    DOI： 10.11312/ccm.44.99

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  • 修正型電気けいれん療法中の血圧に対する低用量プロポフォール+レミフェンタニル併用の影響　後方視的単一施設研究(Effect of low dose propofol combined with remifentanil on blood pressure during modified electroconvulsive therapy: a retrospective, single-center study)

    Shinjo Eriko, Shirozu Kazuhiro, Takamori Shinnosuke, Fukuchi Kaho, Ozasa Shoko, Kobayashi Atsushi, Cho Sungsam, Higashi Midoriko, Yamaura Ken

    循環制御   43 ( 2 )   71 - 76   2022.12   （ ISSN:0389-1844 ）

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    修正型電気けいれん療法(m-ECT)中の麻酔薬投与量減少に伴う血圧の変化を調べた。2015年9月～2020年2月に1コース8回以上のm-ECTを受けた患者91名のデータを用いる後方視的研究を行った。患者を、使用した麻酔薬の種類別にプロポフォール1μg/mL+レミフェンタニル群(PR群)65名(男性40%、平均58.8±15.3歳)とプロポフォール群(P群)26名(男性46.2%、平均64.0±15.8歳)に分け、m-ECT中の血圧変化を比較した。高血圧の予防/治療目的での降圧薬(ニカルジピン1mg静注)投与は、麻酔科の判断で行った。その結果、m-ECT中の収縮期血圧が180mmHg以上の患者はPR群がP群より有意に多かった(p=0.004)。ニカルジピンの投与回数はPR群がP群に比べて有意に多かった(p=0.0004)。低用量プロポフォールとレミフェンタニルの併用はプロポフォール単剤による麻酔に比べて、m-ECT中の血圧とニカルジピンの使用回数を有意に増加させることが示された。

  • Cervical selective nerve root injection alleviates chronic refractory pain after brachial plexus avulsion: a case report. International journal

    Yoji Chikama, Aiko Maeda, Ryudo Tanaka, Masachika Tominaga, Kazuhiro Shirozu, Ken Yamaura

    JA clinical reports   8 ( 1 )   84 - 84   2022.10   （ ISSN:2363-9024 ）

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    BACKGROUND: Intractable chronic pain, as well as motor, sensory, and autonomic neuropathy, significantly reduces the quality of life of brachial plexus avulsion (BPA) patients. We report the successful application of cervical selective nerve root injection (CSNRI) in a patient with BPA. CASE PRESENTATION: A 40-year-old man had been diagnosed with complete left BPA due to a motorcycle accident and underwent intercostal nerve transplantation at the age of 18 years and had been experiencing pain ever since. His pain increased after fracture of the left humerus, and he was referred to our pain management clinic. As his exacerbated pain was suspected to be due to peripheral nerve hypersensitivity, we performed repetitive ultrasound-guided CSNRI (3 mL of 1% mepivacaine of each) targeted C5 and 6 intervertebral foramina, and his symptoms gradually improved. CONCLUSIONS: Repetitive CSNRI may help diagnose and treat BPA-associated peripheral neuropathic pain, even in patients diagnosed with BPA.

    DOI： 10.1186/s40981-022-00574-9

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  • Multidisciplinary pain treatment for complex regional pain syndrome in bilateral upper extremities after median sternotomy: a case report

    INOUE Yuka, MAEDA Aiko, NAKAYAMA Shouko, YAMAMOTO Misaki, SHIROUZU Kazuhiro, YAMAURA Ken

    Journal of Japan Society of Pain Clinicians   29 ( 9 )   202 - 205   2022.9   （ ISSN:13404903 eISSN:18841791 ）

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    Language：Japanese   Publisher：Japan Society of Pain Clinicians  

    <p>Case: A 68-year-old man underwent cardiac surgery including internal mammary artery dissection using sternal retraction. The day after surgery, he had pain with numbness in the left medial forearm and ulnar side fingers. Two months after surgery, similar symptoms appeared on the right side, gradually, edema and contractures developed in both hands. He was referred to our department 4 months after the surgery. His symptoms, with significant pain and contracture of both hands, met the diagnostic criteria for CRPS. We have performed rehabilitation, pain awareness education, medication, and twelve times ultrasound-guided brachial plexus block (1％ mepivacaine) to control his symptoms. After approximately five months of these treatments, the patient's impeded bilateral upper limbs motion and pain were notably improved. Conclusion: Early multidisciplinary treatment initiation could ameliorate intractable pain syndrome such as complex regional pain syndrome induced by cardiac surgery-related brachial plexus injury.</p>

    DOI： 10.11321/jjspc.22-0018

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  • A pressure-resistant peripherally inserted central catheter is as useful as a central venous catheter for rapid fluid infusion: an in vitro study. International journal

    Jun Maki, Makoto Sumie, Tomoko Ide, Masako Nagamatsu, Katsuyuki Matsushita, Kazuhiro Shirozu, Midoriko Higashi, Ken Yamaura

    BMC anesthesiology   22 ( 1 )   205 - 205   2022.7   （ ISSN:1471-2253 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMC Anesthesiology  

    BACKGROUND: Although peripherally inserted central catheters (PICCs) have been widely used, they have not been frequently used in anesthesia practice. The central venous pressure measured via PICCs are reportedly as accurate as that measured via central venous catheters (CVCs), but the findings concerning rapid infusion are unclear. This study examined whether or not pressure-resistant PICCs could be used for rapid fluid infusion.  METHODS: The in-line pressure was measured in similar-sized double-lumen catheters-4-Fr PICC (55, 45 and 35 cm) and 17-G CVC (20 and 13 cm)-at flow rates of saline decided using a roller pump system. We also examined the flow rate at an in-line pressure of 300 mmHg, which is the critical pressure at which hemolysis is considered to occur during blood transfusion. RESULTS: The pressure-resistant PICCs obtained a high flow rate similar to that of CVCs, but the in-line pressures increased in proportion to the flow rate and catheter length. Flow rates at an intra-circuit pressure of 300 mmHg were not significantly different between the 45-cm PICC and 20-cm CVC. CONCLUSION: Pressure-resistant PICCs can be used for rapid fluid infusion.

    DOI： 10.1186/s12871-022-01738-x

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  • The relationship between EMG and processed EEG.

    Kazuhiro Shirozu, Ken Yamaura

    Journal of anesthesia   36 ( 3 )   445 - 446   2022.5   （ ISSN:0913-8668 eISSN:1438-8359 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publisher：Journal of Anesthesia  

    DOI： 10.1007/s00540-022-03074-3

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  • Anesthetic management of cesarean section in a patient with Takayasu's arteritis: a case report. International journal

    Taichi Ando, Makoto Sumie, Shoichi Sasaki, Miho Yoshimura, Keiko Nobukuni, Jun Maki, Katsuyuki Matsushita, Kazuhiro Shirozu, Midoriko Higashi, Ken Yamaura

    JA clinical reports   8 ( 1 )   1 - 1   2022.1   （ ISSN:2363-9024 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JA Clinical Reports  

    BACKGROUND: Takayasu's arteritis (TA) is a chronic, progressive, inflammatory arteritis. We presented the case of cesarean section in a patient with TA. CASE PRESENTATION: A 31-year-old pregnant woman with TA underwent a planned cesarean section at 34 weeks of pregnancy. She had stenosis of the cerebral and coronary arteries and heart failure due to aortic regurgitation. Spinal anesthesia was performed. In addition to standard monitoring, arterial blood pressure in the dorsalis pedis artery and regional cerebral tissue oxygen saturation were monitored. Intraoperative arterial blood pressure was maintained using continuous infusion of noradrenaline with a careful intermittent bolus infusion of phenylephrine. All the procedures were successfully performed without significant complications. CONCLUSIONS: In a pregnant woman with TA, severe stenosis of the cerebral and coronary arteries, and heart failure due to valvular heart disease, careful anesthetic management by selecting catecholamines and assessing the perfusion pressure for critical organs is important.

    DOI： 10.1186/s40981-021-00494-0

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  • Effect of low dose propofol combined with remifentanil on blood pressure during modified electroconvulsive therapy: a retrospective, single-center study

    Shinjo Eriko, Shirozu Kazuhiro, Takamori Shinnosuke, Fukuchi Kaho, Ozasa Shoko, Kobayashi Atsushi, Cho Sungsam, Higashi Midoriko, Yamaura Ken

    CIRCULATION CONTROL   43 ( 2 )   71 - 76   2022   （ ISSN:03891844 ）

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    Language：English   Publisher：Japan Society of Circulation Control in Medicine  

    <b>Introduction:</b> Modified electroconvulsive therapy (m-ECT) is mainly used to induce seizures. The use of anesthetic agents during m-ECT should be minimized because they could inhibit the development of seizures. Modifying the method of administration of anesthetic in combination with opioid use is known to help in reduction of the anesthetic dose. However, the effect of this dose reduction on circulatory dynamics during m-ECT has not been studied in detail. Therefore, we conducted this study to investigate the changes in blood pressure associated with anesthetic dose reduction during m-ECT. <br><b>Methods:</b> Ninety-one patients who underwent m-ECT eight or more times per course (455 m-ECT procedures in total) were included. The data were extracted retrospectively from anesthesia and electronic medical records from September 2015 to February 2020. The changes in blood pressure during m-ECT were compared between the following groups: propofol and remifentanil (PR group: remifentanil followed by propofol [1 µg/mL] based on target control infusion until loss of consciousness) and propofol alone (P group: propofol [2 µg/mL] based on target control infusion until loss of consciousness). <br><b>Results:</b> Of the 455 procedures (91 patients), 325 (65 patients) were performed in the PR group and 130 (26 patients) in the P group. Systolic blood pressure ≥180 mmHg during m-ECT was significantly more in the PR group than in the P group (73/325 vs. 14/130, p＝0.004). <br><b>Conclusion:</b> The use of a reduced dose of propofol in combination with remifentanil significantly increased blood pressure and the use of nicardipine than did propofol alone during m-ECT.

    DOI： 10.11312/ccm.43.71

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  • Treatment of trigeminal and glossopharyngeal neuralgia in an adolescent: a case report. International journal

    Aiko Maeda, Kenzo Araki, Chiaki Yamada, Shoko Nakayama, Kazuhiro Shirozu, Ken Yamaura

    JA clinical reports   7 ( 1 )   61 - 61   2021.8

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    DOI： 10.1186/s40981-021-00465-5

  • 1-kHz high-frequency spinal cord stimulation alleviates chronic refractory pain after spinal cord injury: a case report. International journal

    Chiaki Yamada, Aiko Maeda, Katsuyuki Matsushita, Shoko Nakayama, Kazuhiro Shirozu, Ken Yamaura

    JA clinical reports   7 ( 1 )   46 - 46   2021.6

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    DOI： 10.1186/s40981-021-00451-x

  • Anesthetic management of laparoscopy-assisted total proctocolectomy in a cardiac sarcoidosis patient with a cardiac resynchronization therapy-defibrillator a case report Reviewed

    Yutaro Kammura, Ai Fujita, Yuji Karashima, Shoko Nakayama, Kazuhiro Shirozu, Tadashi Kandabashi, Ken Yamaura

    JA Clinical Reports   6 ( 1 )   43   2020.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40981-020-00350-7

  • 脳外科術後の体位変換時に肺血栓塞栓症を発症した1例 Reviewed

    織田寛子、辛島裕士、牧盾、山本美佐紀、白水和宏、外須美夫

    日本臨床麻酔学会誌   38 ( 4 )   438 - 443   2018.7

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  • Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia Reviewed

    Eizo Marutani, Marina Yamada, Tomoaki Ida, Kentaro Tokuda, Kohei Ikeda, Shinichi Kai, Kazuhiro Shirozu, Kei Hayashida, Shizuko Kosugi, Kenjiro Hanaoka, Masao Kaneki, Takaaki Akaike, Fumito Ichinose

    Journal of the American Heart Association   4 ( 11 )   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/JAHA.115.002125

  • Beneficial effects of nitric oxide on outcomes after cardiac arrest and cardiopulmonary resuscitation in hypothermia-treated mice Reviewed

    Kotaro Kida, Kazuhiro Shirozu, Binglan Yu, Joseph B. Mandeville, Kenneth D. Bloch, Fumito Ichinose

    Anesthesiology   120 ( 4 )   880 - 889   2014.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/ALN.0000000000000149

  • 先天性無フィブリノゲン血症妊婦の帝王切開術の麻酔経験

    崎村　正太郎, 杉岡　章光, 名西　紀子, 白水 和宏, 東 みどり子, 山浦 健, 外 須美夫

    日本臨床麻酔学会誌   2010.10

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  • Diabetes-associated alterations in volatile anesthetic actions on contractile response to norepinephrine in isolated mesenteric resistance arteries Reviewed

    Jun Yoshino, Takashi Akata, Kazuhiro Shirozu, Kaoru Izumi, Sumio Hoka

    Anesthesiology   112 ( 3 )   595 - 606   2010.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/ALN.0b013e3181ce9e80

  • Reliability of temperatures measured at standard monitoring sites as an index of brain temperature during deep hypothermic cardiopulmonary bypass conducted for thoracic aortic reconstruction Reviewed

    Takashi Akata, Hidekazu Setoguchi, Kazuhiro Shirozu, Jun Yoshino

    Journal of Thoracic and Cardiovascular Surgery   133 ( 6 )   1559 - 1565.e2   2007.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jtcvs.2006.11.031

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Books

  • 麻酔科プラクティス８　麻酔管理の疑問に答える生理学「なぜ血圧の呼吸性変動が起こるのか？」

    白水和宏（Role：Joint author）

    2023.4 

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    Language：Japanese   Book type：Scholarly book

  • 麻酔科プラクティス８　麻酔管理の疑問に答える生理学「心臓反射にはどのようなものがあるのか？

    白水和宏（Role：Joint author）

    2023.4 

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    Language：Japanese   Book type：Scholarly book

  • 腎臓移植・膵臓移植　麻酔科プラクティス6　Challenge 緊急手術の麻酔

    白水和宏、山浦 健

    2021.11 

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    Language：Japanese  

  • ショック・心不全　周術期の薬の使い方　パーフェクトガイド

    白水和宏、山浦健（Role：Joint author）

    月刊薬事  2021.1 

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    Responsible for pages：p67-80, 2021 Vol.63 No. 3   Language：Japanese   Book type：Scholarly book

  • 麻酔科研修ノート　（間質性肺炎）

    診断と治療社  2024.11 

  • DECISION MAKING IN Perioperative Medicine: CLINICAL PEARLS(7．Prevention of Surgical Site Infections)

    （Role：Contributor）

    MEDSi  2023.5 

  • 神経麻酔　最前線　術後脳機能（せん妄）とデクスメデトミジン

    白水和宏、山浦健（Role：Joint author）

    2021.6 

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    Responsible for pages：32-36   Language：Japanese  

  • 周術期管理チームテキスト　第四版「体表の手術の麻酔」

    白水和宏（Role：Joint author）

    2021.4 

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    Responsible for pages：p657-660   Language：Japanese   Book type：Scholarly book

  • 麻酔科プラクティス 2 各種手術の輸液・輸血戦略（肝移植・腎移植）

    白水和宏、山浦健（Role：Joint author）

    文光堂  2020.6 

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    Responsible for pages：308-313   Language：Japanese   Book type：Scholarly book

  • 周術期管理チームテキスト　第三版　「体表の手術の麻酔」

    白水和宏（Role：Joint author）

    2016.7 

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    Responsible for pages：657-660   Language：Japanese   Book type：Scholarly book

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Presentations

  • SEF (spectral edge frequency)、DSA (density spectral array)の有効性 Invited

    白水和宏

    日本臨床麻酔学会  2023.11 

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    Event date： 2023.11

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Country：Japan  

  • PONV and pain after Anesthesia with Remimazolam: An Exploratory, Randomised, Open, Propofol-Controlled, Single-Centre Clinical Trial International conference

    Tomoko Murakami, Kazuhiro Shirozu, Keiko Nobukuni, Aiko Maeda, Midoriko Higashi, Ken Yamaura

    ASA  2023.10 

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    Event date： 2023.10 - 2024.4

    Language：English  

    Country：United States  

  • サージカルマスクが酸素療法に与える影響の検討

    白水和宏、大屋皆既、髙森信乃介、十時崇彰、牧盾、徳田賢太郎、山浦健

    日本呼吸療法医学会学術集会  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 手術室空気環境と感染症 Invited

    白水和宏

    日本麻酔科学会  2023.5 

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    Event date： 2023.4

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 血漿交換の違いによる血球成分の変化の検討

    白水和宏、平安山知子、大屋皆既、牧盾、山浦健

    日本集中治療医学会学術集会  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 帝王切開時の循環モニタリング Invited

    白水和宏

    日本周産期麻酔科学会  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • The investigation of factors associated with postoperative shivering International conference

    Kazuhiro Shirozu, Mizuko Ikeda, Yutaro Kammura, Ken yamaura

    European Society of Anaesthesiology  2020.11 

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    Event date： 2020.11

    Language：English   Presentation type：Oral presentation (general)  

    Venue：BARCELONA   Country：Spain  

  • 間質性肺炎の術後急性増悪に影響を与える因子の検討

    牧嶋 啓, 冨士本 遼子, 白水 和宏, 池田 水子, 山浦 健

    日本麻酔科学会  2020.6 

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    Event date： 2020.6

    Language：Japanese  

    Venue：神戸   Country：Japan  

  • Effects of surgical light and forced air warming on air flow of the operating room with conventional airflow systems International conference

    Kazuhiro Shirozu, Tetsuya Kai, Hidekazu Setoguchi, Ken Yamaura

    Anesthesiology annual meeting 2019  2019.10 

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    Event date： 2019.10

    Language：English   Presentation type：Oral presentation (general)  

    Venue：米国　オーランド   Country：United States  

  • Effects of Preoperative Plasma Exchange Therapy on Blood Coagulation in Patients Undergoing Abo-incompatible Living-donor Kidney International conference

    Masatsugu Watanabe, Kazuhiro Shirozu, Tsukasa Shimauchi, Yuji Karashima, Sumio Hoka,

    Anesthesiology annual meeting 2018  2018.10 

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    Event date： 2018.10

    Language：English  

    Venue：サンフランシスコ   Country：United States  

  • Pupillary Response for Assessment of the Efficacy of Electroconvulsive Therapy Using an Automated Pupilometer International conference

    Kazuhiro Shirozu,, Yuji Karashima, Hidekazu Setoguchi, Sumio Hoka

    Anesthesiology annual meeting 2018  2018.10 

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    Event date： 2018.10

    Language：English  

    Country：United States  

  • ボルベン輸液６％が生体腎移植ドナー患者へ及ぼす影響の検討

    冨士本遼子、白水和宏、島内司、辛島裕士

    九州麻酔科学会第56回大会  2018.9 

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    Event date： 2018.9

    Language：Japanese  

    Venue：沖縄   Country：Japan  

  • 電気けいれん療法による痙攣誘発の有効性評価として瞳孔径変化が指標となりえるか？

    江里朋香、白水和宏、島内司、辛島裕士、瀬戸口秀一

    九州麻酔科学会第56回大会  2018.9 

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    Event date： 2018.9

    Language：Japanese  

    Venue：沖縄   Country：Japan  

  • 妊娠に伴うヤコビ線の位置変化と麻酔科医の認識のずれの検討

    大岩 真由子、白水 和宏、島内 司、木村 真実、辛島 裕士、外 須美夫

    日本麻酔科学会第65回学術集会  2018.5 

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    Event date： 2018.5

    Language：Japanese  

    Venue：横浜   Country：Japan  

  • Usability of ROTEM for Indicator of Clotting Ability After Cardiopulmonary Bypass During Open Heart Surgery International conference

    Kazuhiro Shirozu, @Yuji Karashima, @Sumio Hoka

    SCA 40th Annual Meeting  2018.5 

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    Event date： 2018.4 - 2018.5

    Language：English  

    Venue：Phoenix, AZ   Country：United States  

  • 術中体位により腕神経叢損傷を生じた症例

    田原康次郎, 白水 和宏, 島内 司, 辛島 裕士, 外 須美夫

    日本臨床麻酔学会第37回大会  2017.11 

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    Event date： 2017.11

    Language：Japanese  

    Country：Japan  

  • Effects of renal graft size on hemodynamic change in pediatric renal transplantation

    T Fukudome, K Shirozu, Y Karashima, Sumio Hoka

    Anesthesiology annual meeting 2017  2017.10 

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    Event date： 2017.10

    Language：English  

    Country：Japan  

  • 麻酔器搭載型電動シーリングペンダントの術前手術室準備における有効性の検討

    梶取尚世, 福本瑞穂, 一法師久美子, 白水 和宏, 瀨戸口 秀一, 森本武志, 甲斐哲也, 外 須美夫

    第39回日本手術医学会総会  2017.10 

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    Event date： 2017.10

    Language：Japanese  

    Country：Japan  

  • 術後長期間呼吸管理を要した縦隔リンパ管腫症の一例

    仁田畑和紀, 河野裕美, 白水 和宏, 田口祥子, 辛島 裕士, 外 須美夫

    九州麻酔科学会第55回大会  2017.9 

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    Event date： 2017.9

    Language：Japanese  

    Venue：大分   Country：Japan  

  • 非心臓小児手術におけるボルベン(HES130/0.4)の腎機能への影響の検討 —第２報

    川副 明生, 白水 和宏, 松下 克之, 辛島 裕士, 外 須美夫

    ６４回　日本麻酔科学会  2017.6 

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    Event date： 2017.6

    Language：Japanese  

    Venue：神戸   Country：Japan  

  • 人工心肺離脱後の残存ヘパリンが凝固系に及ぼす影響の検討

    渡邊 雅嗣, 白水 和宏, 瀨戸口 秀一, 外 須美夫

    日本集中治療医学会第1回九州支部学術集会  2017.5 

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    Event date： 2017.5

    Language：Japanese  

    Venue：長崎   Country：Japan  

  • The effects of forced air warming on air flow around operating table

    K Shirozu, T Kai, H Setoguchi, S Hoka

    IARS 2017 annual meeting  2017.5 

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    Event date： 2017.5

    Language：English  

    Venue：Washington, DC USA   Country：Japan  

  • 経カテーテル大動脈弁置換術（TAVI）における傍脊椎神経ブロックの安全性と有効性の検討

    河野 裕美, 白水 和宏, 本山 嘉正, 辛島 裕士, 塩瀬 明, 外 須美夫

    日本区域麻酔学会  2017.4 

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    Event date： 2017.4

    Language：Japanese  

    Venue：名古屋   Country：Japan  

  • アドレナリン局所注入後に発生した頻拍発作の治療に難渋した症例

    竹内愛美, 白水 和宏, 辛島 裕士, 瀨戸口 秀一, 外 須美夫

    日本臨床麻酔学会第３６回大会  2016.11 

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    Event date： 2016.11

    Language：Japanese  

    Venue：高知   Country：Japan  

  • Effects of HES 130/0.4 on albumin consumption and renal function in infants undergoing major surgery International conference

    Y Soeda, K Shirozu, Yuji Karashima, Sumio Hoka

    ASA annual meeting 2016  2016.10 

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    Event date： 2016.10

    Language：English  

    Venue：Chicago   Country：United States  

  • The effects of cardiopulmonary bypass on the clotting system in cardiac surgery International conference

    K Shirozu, Yuji Karashima, Tadashi Kandabashi, Sumio Hoka

    ASA annual meeting 2016  2016.10 

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    Event date： 2016.10

    Language：English  

    Venue：Chicago   Country：United States  

  • 傍脊椎ブロック施行後に一過性の対麻痺を来した一例

    川副明生, 荒木健三, 白水 和宏, 松下 克之, 辛島 裕士, 外 須美夫

    九州麻酔科学会第５４回大会  2016.9 

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    Event date： 2016.9

    Language：Japanese  

    Venue：佐賀   Country：Japan  

  • 人工心肺が凝固系に及ぼす影響:ROTEM を用いた検討

    添田祐治, 白水和宏, 辛島裕士, 瀬戸口秀一, 外須美夫

    第 26 回日本集中治療医学会九州地方会  2016.6 

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    Event date： 2016.6

    Language：Japanese  

    Venue：沖縄   Country：Japan  

  • ボルベン　（HES130/0.4）が小児の腎機能・凝固機能に与える影響

    田中　万里子, 白水 和宏, 辛島 裕士, 外 須美夫

    ６３回　日本麻酔科学会  2016.5 

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    Event date： 2016.5

    Language：Japanese  

    Venue：福岡   Country：Japan  

  • 肝切除術中のPringle法による血行動態変化の検討

    白水 和宏, 徳田 賢太郎, 藤吉 哲宏, 瀬戸口 秀一, 外 須美夫

    第４３回　日本集中治療医学会学術集会  2016.2 

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    Event date： 2016.2

    Language：Japanese  

    Venue：神戸   Country：Japan  

  • プロポフォールが瞳孔径に及ぼす影響：赤外線瞳孔計を用いた検討

    白水 和宏, 瀬戸口 秀一, 徳田 賢太郎, 藤吉 哲宏, 外 須美夫

    日本集中治療医学会学術集会　４３回  2016.2 

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    Event date： 2016.2

    Language：Japanese  

    Venue：神戸   Country：Japan  

  • Perioperative Transfusion Management for Living-donor Kidney Transplantation Using Thromboelastometry (ROTEM) International conference

    K Shirozu, Yuji Karashima, S Hoka

    ASA Annual Meeting  2015.10 

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    Event date： 2015.10

    Language：English  

    Country：Japan  

  • Cystathione-lyase deficiency protects mice from galactosamine/LPS-induced acute liver failure

    K Shirozu, Kentaro Tokuda, F Ichinose

    Experimental Biology 2013  2013.4 

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    Event date： 2013.4

    Language：English  

    Venue：Boston   Country：Japan  

  • 摘出ラット肝動脈、腎動脈、腸間膜動脈に対するイソフルランの効果

    白水和宏、吉野淳、泉薫、赤田隆

    第５６回　日本麻酔科学会  2009.8 

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    Event date： 2009.8

    Venue：神戸   Country：Japan  

  • Left Ventricular Diastolic Dysfunction Affects Urinary Output During Kidney Transplantation: A Retrospective Study International conference

    Manami Takeuchi, Tsukasa Shimauchi, Kaoru Umehara, Kazuhiro Shirouzu, Yuji Karashima

    Anesthesiology annual meeting 2018  2018.10 

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    Event date： 2018.10

    Language：English  

    Country：United States  

  • 自発呼吸下で大量出血に対応した慢性呼吸不全の一例

    中島孝輔, 島内 司, 三月田麻理奈, 白水 和宏, 辛島 裕士, 外 須美夫

    九州麻酔科学会第55回大会  2017.9 

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    Event date： 2017.9

    Language：Japanese  

    Country：Japan  

  • 長期インスリン使用患者の心臓外科手術でプロタミンによるアナフィラキシーショックをおこした１例

    新井　千晶, 辛島 裕士, 白水 和宏, 藤吉 哲宏, 外 須美夫

    第38回日本循環制御医学会・学術集会  2017.6 

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    Event date： 2017.6

    Language：Japanese  

    Venue：大阪   Country：Japan  

  • 大腿骨骨接合術中に脂肪塞栓が疑われた１症例

    吉留　彩, 白水 和宏, 牧 盾, 辛島 裕士, 外 須美夫

    第37回日本循環制御医学会総会  2016.7 

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    Event date： 2016.7

    Language：Japanese  

    Venue：東京   Country：Japan  

  • 術中にヘパリン誘発性血小板減少症を疑った１例

    吉留　彩, 杉山　沙織, 白水 和宏, 藤吉 哲宏, 瀬戸口 秀一, 外 須美夫

    第２８回日本老年麻酔学会  2016.2 

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    Event date： 2016.2

    Language：Japanese  

    Venue：長野   Country：Japan  

  • The Effects of Tramadol on Postoperative Shivering After Remifentanil Anesthesia International conference

    T Nakagawa, K Shirozu, S Hoka

    ASA Annual Meeting  2015.10 

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    Event date： 2015.10

    Language：English  

    Venue：San Diego, California   Country：Japan  

  • ラリンジアルマスク下に気管内異物を摘出した小児の一症例

    竹内　愛美, 白水 和宏, 辛島 裕士, 外 須美夫

    日本臨床麻酔学会35回大会  2015.10 

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    Event date： 2015.10

    Language：Japanese  

    Venue：横浜   Country：Japan  

  • 閉塞性肥大型心筋症(HOCM)合併患者での FloTrac による心拍出量測定の限界

    溝口　麻衣, 白水 和宏, 辛島 裕士, 外 須美夫

    臨床麻酔学会　３５回  2015.10 

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    Event date： 2015.10

    Language：Japanese  

    Country：Japan  

  • 先天性高インスリン血症患児に対する膵頭部切除術の麻酔経験

    小野　雄介, 松原　幸恵, 川﨑　翔, 白水 和宏, 辛島 裕士, 外 須美夫

    ５３回　九州麻酔科学会  2015.9 

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    Event date： 2015.9

    Language：Japanese  

    Venue：鹿児島   Country：Japan  

  • 大動脈閉塞バルーンを使用しながら術中管理を行った腹部外傷の一例

    織田　寛子, 中山　昌子, 徳田 賢太郎, 白水 和宏, 辛島 裕士, 外 須美夫

    53回　九州麻酔科学会  2015.9 

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    Event date： 2015.9

    Language：Japanese  

    Venue：鹿児島   Country：Japan  

  • 自己調節硬膜外鎮痛法導入前後での術後鎮痛薬使用量の検討

    夏目　弓子, 白水 和宏, 辛島 裕士, 瀨戸口 秀一, 外 須美夫

    ５３回　九州麻酔科学会  2015.9 

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    Event date： 2015.9

    Language：Japanese  

    Venue：鹿児島   Country：Japan  

  • 心臓移植後の腹腔鏡下高位前方切除術に対する麻酔経験

    冨永　昌周, 白水 和宏, 神田橋 忠, 外 須美夫, 辛島 裕士

    ５２回　九州麻酔科学会  2015.9 

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    Event date： 2015.9

    Language：Japanese  

    Venue：北九州   Country：Japan  

  • 全静脈麻酔からセボフルラン吸入麻酔に切り替えざるを得なかった経鼻的下垂体腫瘍切除術の一例

    新井　千晶, 谷口　奈美, 白水 和宏, 秋吉 浩三郎, 外 須美夫

    ５２回　九州麻酔科学会  2015.9 

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    Event date： 2015.9

    Language：Japanese  

    Venue：北九州   Country：Japan  

  • 瞳孔径に及ぼす麻酔薬の影響：赤外線瞳孔計を用いた検討

    牛尾　春香, 白水 和宏, 辛島 裕士, 外 須美夫, 瀨戸口 秀一

    ６２回　日本麻酔科学会  2015.5 

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    Event date： 2015.5

    Language：Japanese  

    Venue：神戸   Country：Japan  

  • トロンボエラストメトリーを用いた生体腎移植術の周術期輸血管理の検討：術前血漿交換の影響

    藤本　侑里, 山川　眞佐枝, 白水 和宏, 辛島 裕士, 外 須美夫

    ６２回　日本麻酔科学会  2015.5 

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    Event date： 2015.5

    Language：Japanese  

    Venue：神戸   Country：Japan  

  • THE EFFECTS OF ANESTHETIC AGENTS ON PUPILLARY REACTIVITY International conference

    Haruka Ushio, K Shirozu, Yuji Karashima, Hidekazu Setoguchi, Kentaro Tokuda, S Hoka

    IARS 2015 Annual Meeting and International Science Symposium  2015.3 

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    Event date： 2015.3

    Language：English  

    Venue：Honolulu   Country：Japan  

  • 内頸動脈瘤血管内コイル塞栓術後に、胃管操作に伴うと思われる食道粘膜下血腫を生じた一例

    藤本　侑里　, 秋吉 浩三郎, 白水 和宏, 藤吉 哲宏, 神田橋 忠, 瀨戸口 秀一, 外 須美夫

    27回日本老年麻酔科学会  2015.2 

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    Event date： 2015.2

    Language：Japanese  

    Venue：盛岡   Country：Japan  

  • 麻酔中の循環管理に難渋した頸髄損傷患者２症例

    岩松　有希子, 冨永　昌周, 小野　香菜子, 白水 和宏, 辛島 裕士, 外 須美夫

    ５２回　九州麻酔科学会  2014.9 

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    Event date： 2014.9

    Language：Japanese  

    Venue：北九州   Country：Japan  

  • APRVがAuto PEEPに及ぼす影響

    白水和宏　早水憲吾　田口真理子　藤村直幸　財津昭憲　坂口嘉郎　橋爪誠　外須美夫

    日本集中治療学会  2011.2 

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    Event date： 2011.2

    Country：Japan  

  • 吸湿発熱繊維ブランケットの術中患者加温効果の検討　−温風式加温装置との比較−

    江崎　利香　白水　和宏　辛島　裕士 山浦　健　赤田　隆　外　須美夫

    日本麻酔科学会  2010.6 

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    Event date： 2010.6

    Country：Japan  

  • 長時間開腹手術に伴う閾値間域右方移動の程度に関する検討

    田中　麻衣子　白水　和宏　辛島　裕士　赤田　隆　外　須美夫

    日本麻酔科学会  2010.6 

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    Event date： 2010.6

    Country：Japan  

  • CHDF療法における血液濾過器エクセルフローとヘモフィールCH-1.0Nとの有効性及び安全性の比較

    白水和宏、杉森宏、藤吉哲宏、三島博之、橋爪誠

    第３７回　日本集中治療医学会  2010.3 

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    Event date： 2010.3

    Venue：広島   Country：Japan  

  • 周術期の抗凝固療法中止に起因した心筋梗塞の一症例

    渡邉　雅嗣, 白水 和宏, 辛島 裕士, 外 須美夫

    第36回日本循環制御医学会総会・学術集会  2015.6 

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    Language：Japanese  

    Venue：愛知   Country：Japan  

  • SEF(spectral edge frequency),DSA(density spectral array)の有効性

    白水 和宏

    日本臨床麻酔学会誌  2023.11  日本臨床麻酔学会

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  • アロディニアを伴う難治性腰背部痛の原因として充実性偽乳糖状腫瘍が考えられた一例

    山本 美佐紀, 前田 愛子, 中山 昌子, 白水 和宏, 山浦 健

    日本ペインクリニック学会誌  2022.6  (一社)日本ペインクリニック学会

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  • フォンタン術後遠隔期患者に対する腹腔鏡下肝切除術の麻酔管理

    住江 誠, 田中 悠登, 赤坂 泰希, 亀山 希, 中山 昌子, 白水 和宏, 東 みどり子, 山浦 健

    日本成人先天性心疾患学会雑誌  2022.1  (一社)日本成人先天性心疾患学会

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  • 両方向性グレン手術術後患者に対する腹腔鏡下手術の麻酔経験

    古川 愛菜, 水田 幸恵, 中野 良太, 崎村 正太郎, 白水 和宏, 山浦 健

    Cardiovascular Anesthesia  2023.9  (一社)日本心臓血管麻酔学会

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  • 全身麻酔後に高マグネシウム血症が原因と考えられる覚醒遅延をきたした高齢患者の一例

    安藤 太一, 白水 和宏, 東 みどり子, 山浦 健

    日本老年麻酔学会プログラム・抄録集  2024.2  日本老年麻酔学会

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    Language：Japanese  

  • 周術期における循環管理　門脈圧亢進を伴う肝硬変患者の肝切除術

    白水 和宏

    日本循環制御医学会総会プログラム・抄録集  2022.5  日本循環制御医学会

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  • 心臓手術術後の急性腎障害の発症頻度とその背景因子に関する検討

    安藤 太一, 杉山 沙織, 高橋 慶多, 松下 克之, 十時 崇彰, 大澤 さやか, 白水 和宏, 牧 盾, 徳田 賢太郎, 山浦 健

    日本集中治療医学会雑誌  2022.11  (一社)日本集中治療医学会

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    Language：Japanese  

  • 等比重ブピバカインを用いた脊髄くも膜下麻酔時の非侵襲連続推定心拍出量と心拍数との関係

    東 みどり子, 中川 拓, 安藤 太一, 白水 和宏, 山浦 健

    臨床モニター  2024.5  医学図書出版(株)

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    Language：Japanese  

  • 筋電図方式筋弛緩モニタリングが手術体位により困難であった一症例

    信國 桂子, 白水 和宏, 東 みどり子, 山浦 健

    日本手術医学会誌  2023.11  日本手術医学会

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  • 耳朶で測定した脈派伝搬時間の変化率は手指パルスオキシメータの代用となる

    小佐々 翔子, 東 みどり子, 中野 良太, 白水 和宏, 山浦 健

    日本循環制御医学会総会プログラム・抄録集  2023.6  日本循環制御医学会

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  • 脊髄くも膜下麻酔時の非侵襲連続推定心拍出量についての検討

    中川 拓, 白水 和宏, 東 みどり子, 山浦 健

    日本循環制御医学会総会プログラム・抄録集  2024.6  日本循環制御医学会

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  • 薬剤関連顎骨壊死による難治性疼痛に対し下顎神経ブロック高周波熱凝固法が奏功した一例

    篠塚 翔, 前田 愛子, 山本 美佐紀, 中山 昌子, 白水 和宏, 山浦 健

    日本ペインクリニック学会誌  2022.6  (一社)日本ペインクリニック学会

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  • 血液粘弾性試験を用いた大量出血時の適切なトラネキサム酸投与量のモニタリング

    中野 友貴, 十時 崇彰, 白水 和宏, 東 みどり子, 山浦 健

    臨床モニター  2023.4  医学図書出版(株)

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  • 関節型Ehlers-Danlos症候群疑い患者に対する全身麻酔の経験

    舩津 康孝, 河津 絵梨菜, 白水 和宏, 東 みどり子, 山浦 健

    日本手術医学会誌  2022.10  日本手術医学会

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    Language：Japanese  

  • 非侵襲的心拍出量モニタリングの有効性と問題点

    白水 和宏

    日本循環制御医学会総会プログラム・抄録集  2022.5  日本循環制御医学会

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  • 高齢の手術予定患者における高血圧の実態

    徳永 真柚, 東 みどり子, 白水 和宏, 山浦 健

    日本老年麻酔学会プログラム・抄録集  2023.3  日本老年麻酔学会

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  • 血漿交換の違いによる血球成分の変化の検討

    白水 和宏, 平安山 知子, 大屋 皆既, 牧 盾, 山浦 健

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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  • 脊髄くも膜下硬膜外併用麻酔に高度徐脈を来した一例

    大角 崇史, 水田 幸恵, 藤吉 哲宏, 松下 克之, 白水 和宏, 東 みどり子, 山浦 健

    日本循環制御医学会総会プログラム・抄録集  2022.5  日本循環制御医学会

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  • 経カテーテル肺動脈弁留置術の麻酔管理

    安藤 太一, 小佐々 翔子, 水田 幸恵, 辛島 裕士, 白水 和宏, 山浦 健

    Cardiovascular Anesthesia  2023.9  (一社)日本心臓血管麻酔学会

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  • 手術器具装置の超過請求額把握の取り組み

    白水 和宏, 松岡 美恵, 瀬戸口 秀一, 嶋吉 秋穂, 山浦 健, 中島 康晴

    日本手術医学会誌  2024.12  日本手術医学会

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  • 周術期の尿道カテーテル非挿入に伴う安全性の検討

    木下 弘貴, 佐藤 里圭子, 鷹羽 佑佳, 佐々木 裕幸, 松岡 美恵, 白水 和宏, 高森 遼子, 東 みどり子, 山浦 健

    日本手術医学会誌  2024.12  日本手術医学会

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    Language：Japanese  

  • モデル肺を用いたサージカルマスクによる吸入酸素濃度の検討

    白水 和宏, 高森 信乃介, 崎村 正太郎, 山浦 健

    日本集中治療医学会雑誌  2024.9  (一社)日本集中治療医学会

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    Language：Japanese  

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MISC

  • 電気けいれん療法による誘発痙攣の有効性評価としての瞳孔径変化 Reviewed

    白水和宏

    日臨麻酔会誌   2020.5

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 瞳孔反応測定の有効性

    白水 和宏、山浦 健

    臨床麻酔   2019.7

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    Language：Japanese  

  • SERVO-i でのBi-Vent モードの使用経験

    白水和宏

    人工呼吸   2011.5

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Reply to the letter by Satici MH

    Umehara Kaoru, Shirozu Kazuhiro, Yamaura Ken

    Journal of Anesthesia   38 ( 5 )   730 - 731   2024.10   （ ISSN:0913-8668 ）

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    Language：English   Publisher：(公社)日本麻酔科学会  

  • 症例ライブラリー　周術期の低体温　麻酔管理中に体温がみるみる下がってしまった

    白水 和宏

    LiSA   30 ( 12 )   1268 - 1271   2023.12   （ ISSN:1340-8836 ）

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    Language：Japanese   Publisher：(株)メディカル・サイエンス・インターナショナル  

  • 【周術期における循環管理】門脈圧亢進を伴う肝硬変患者の肝切除術

    白水 和宏

    循環制御   44 ( 2 )   80 - 82   2023.12   （ ISSN:0389-1844 ）

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    Language：Japanese   Publisher：日本循環制御医学会  

  • 血漿交換の違いによる血球成分の変化の検討

    白水 和宏, 平安山 知子, 大屋 皆既, 牧 盾, 山浦 健

    日本集中治療医学会雑誌   30 ( Suppl.1 )   S837 - S837   2023.6   （ ISSN:1340-7988 eISSN:1882-966X ）

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    Language：Japanese   Publisher：(一社)日本集中治療医学会  

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  • 血液粘弾性試験を用いた大量出血時の適切なトラネキサム酸投与量のモニタリング

    中野 友貴, 十時 崇彰, 白水 和宏, 東 みどり子, 山浦 健

    臨床モニター   34 ( Suppl. )   57 - 57   2023.4   （ ISSN:0915-6976 ）

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    Language：Japanese   Publisher：医学図書出版(株)  

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  • 高齢の手術予定患者における高血圧の実態

    徳永 真柚, 東 みどり子, 白水 和宏, 山浦 健

    日本老年麻酔学会プログラム・抄録集   35回   48 - 48   2023.3

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    Language：Japanese   Publisher：日本老年麻酔学会  

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  • 4．門脈圧亢進を伴う肝硬変患者の肝切除術 Invited

    白水 和宏

    CIRCULATION CONTROL   44 ( 2 )   80 - 82   2023   （ ISSN:03891844 ）

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：Japan Society of Circulation Control in Medicine  

    DOI： 10.11312/ccm.44.80

    CiNii Research

  • サージカルマスクが酸素療法に与える影響の検討

    白水和宏, 大屋皆既, 高森信乃介, 十時崇彰, 牧盾, 徳田賢太郎, 山浦健

    日本呼吸療法医学会学術集会プログラム・抄録集   45th (CD-ROM)   2023

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  • 耳朶で測定した脈派伝搬時間の変化率は手指パルスオキシメータの代用となる

    小佐々翔子, 東みどり子, 中野良太, 白水和宏, 山浦健

    日本循環制御医学会総会・学術集会プログラム・抄録集   44th   2023

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  • 経カテーテル肺動脈弁留置術の麻酔管理

    安藤太一, 小佐々翔子, 水田幸恵, 辛島裕士, 辛島裕士, 白水和宏, 山浦健

    Cardiovascular Anesthesia   27 ( Suppl (CD-ROM) )   2023   （ ISSN:1342-9132 ）

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  • 筋電図方式筋弛緩モニタリングが手術体位により困難であった一症例

    信國桂子, 白水和宏, 東みどり子, 山浦健

    日本手術医学会誌   44   2023   （ ISSN:1340-8593 ）

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  • 両方向性グレン手術術後患者に対する腹腔鏡下手術の麻酔経験

    古川愛菜, 水田幸恵, 中野良太, 崎村正太郎, 白水和宏, 山浦健

    Cardiovascular Anesthesia   27 ( Suppl (CD-ROM) )   2023   （ ISSN:1342-9132 ）

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  • 心臓手術術後の急性腎障害の発症頻度とその背景因子に関する検討

    安藤 太一, 杉山 沙織, 高橋 慶多, 松下 克之, 十時 崇彰, 大澤 さやか, 白水 和宏, 牧 盾, 徳田 賢太郎, 山浦 健

    日本集中治療医学会雑誌   29 ( Suppl.1 )   613 - 613   2022.11   （ ISSN:1340-7988 eISSN:1882-966X ）

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    Language：Japanese   Publisher：(一社)日本集中治療医学会  

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  • EMGとprocessed EEGの関係(The relationship between EMG and processed EEG)

    Shirozu Kazuhiro, Yamaura Ken

    Journal of Anesthesia   36 ( 3 )   445 - 446   2022.6   （ ISSN:0913-8668 ）

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    Language：English   Publisher：(公社)日本麻酔科学会  

  • 脊髄くも膜下硬膜外併用麻酔に高度徐脈を来した一例

    大角 崇史, 水田 幸恵, 藤吉 哲宏, 松下 克之, 白水 和宏, 東 みどり子, 山浦 健

    日本循環制御医学会総会プログラム・抄録集   43回   48 - 48   2022.5

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    Language：Japanese   Publisher：日本循環制御医学会  

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  • 周術期における循環管理 門脈圧亢進を伴う肝硬変患者の肝切除術

    白水 和宏

    日本循環制御医学会総会プログラム・抄録集   43回   31 - 31   2022.5

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    Language：Japanese   Publisher：日本循環制御医学会  

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  • 非侵襲的心拍出量モニタリングの有効性と問題点

    白水 和宏

    日本循環制御医学会総会プログラム・抄録集   43回   38 - 38   2022.5

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    Language：Japanese   Publisher：日本循環制御医学会  

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  • Anesthetic management of hepatectomy in patient with Fontan circulation

    住江誠, 田中悠登, 赤坂泰希, 亀山希, 中山昌子, 白水和宏, 東みどり子, 山浦健

    日本成人先天性心疾患学会雑誌(Web)   11 ( 1 )   2022

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  • ECT を臨床モデルとした生理学的研究：自律神経系での研究例 Reviewed

    白水 和宏、山浦 健

    臨床麻酔   2021.3

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 輪状軟骨圧迫法の問題点

    塩川 浩輝、辛島 裕士、秋吉 浩三郎、東 みどり子、宮崎 良平、瀬戸口 秀一、本山　嘉正、白水 和宏、徳田 賢太郎、藤吉 哲宏、神田橋 忠、清水 祐紀子、外 須美夫

    臨床麻酔   2014.7

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • 日本麻酔科学会

  • 日本区域麻酔学会

  • 日本老年麻酔学会

  • 日本Awake surgery学会

  • 日本循環制御医学会

  • 日本周産期麻酔科学会

  • 日本産科麻酔学会

  • 日本神経麻酔集中治療学会

  • 日本手術医学会

  • 日本ペインクリニック学会

  • 日本臨床モニター学会

  • 日本臨床麻酔科学会

  • 日本集中治療学会

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Committee Memberships

  • 日本麻酔科学会   日本麻酔科学会事務局委員  

    2025.6 - Present   

  • 日本区域麻酔学会   認定医認定委員  

    2025.4 - Present   

  • 日本臨床麻酔学会   学会誌編集委員  

    2025.4 - Present   

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    Committee type：Academic society

  • 日本臨床麻酔学会   評議員   Domestic

    2024.12 - Present   

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    Committee type：Academic society

  • 区域麻酔学会   Councilor   Domestic

    2023.4 - Present   

  • 循環制御医学会   Councilor   Domestic

    2021.4 - Present   

  • 循環制御医学会   学会誌編集委員   Domestic

    2021.4 - Present   

  • 日本麻酔科学会   代議員   Domestic

    2021.4 - Present   

  • 日本麻酔科学会   国際交流委員会   Domestic

    2021.4 - 2023.3   

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Academic Activities

  • 肝臓移植の周術期管理

    日本臨床麻酔学会 第44回大会  2024.11

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    Type：Competition, symposium, etc. 

  • 手術部位感染（SSI）を防ぐ

    麻酔科学会支部周術期管理チームセミナー　  （ Japan ） 2023.9

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    Type：Competition, symposium, etc. 

  • 「手術室空気環境と感染症」

    日本麻酔科学会第70回学術集会　  （ Japan ） 2023.6

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2023

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • 演者 International contribution

    The 16th Asian Australasian Congress of Anesthesiologists (AACA) in 2022  （ Seol Korea ） 2022.11

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    Type：Competition, symposium, etc. 

  • 演者

    第43回循環制御医学会「周術期における循環管理　門脈圧亢進症の肝切除の麻酔管理」  （ Japan ） 2022.4 - 2022.6

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2022

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

  • 日本循環制御医学会誌

    2021.4 - 2023.3

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    Type：Academic society, research group, etc. 

  • 演者

    第33回老年麻酔学会 (2021)　シンポジウム「手術室環境と感染対策」  （ Japan ） 2021.3

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：5

  • 演者

    臨床麻酔学会第39回大会 「ECTの効果判定と麻酔」  （ Japan ） 2019.11

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    Type：Competition, symposium, etc. 

  • 演者

    九州麻酔科学会第57回大会 (感染対策)専門医共通講習　「手術部位感染」  （ Japan ） 2019.9

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    Type：Competition, symposium, etc. 

  • 演者

    麻酔科学会支部周術期管理チームセミナー　 周術期医療の質向上を目指す体温管理  （ Japan ） 2019.9

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    Type：Competition, symposium, etc. 

  • 演者

    2019年度日本手術医学会教育セミナー　「体温管理の基礎と実践」  （ Japan ） 2019.6

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2019

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2018

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

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Research Projects

  • エンドサイトーシス受容体を介した周術期急性腎障害の慢性腎臓病への移行に関する検討

    Grant number：23K08334  2023.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    松下 克之, 水田 幸恵, 白水 和宏, 東 みどり子, 山浦 健

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    Grant type：Scientific research funding

    周術期に急性腎障害が発症すると入院期間、術後30日死亡率が増加することが知られている。さらに、周術期の急性腎障害は短期死亡率を増加させるだけでなく、術後の慢性的な腎機能悪化を引き起こすことが報告されている。しかし、この現象の詳細な機序は不明であり、有効な予防法も存在しない。
    本研究の目的は、(1) 周術期に発症する急性腎障害の治療法の確立と(2) 急性腎障害が慢性腎臓病への移行する原因とその予防法を基礎的研究により明らかにすることである。

    CiNii Research

  • The effecacy of phosphasil serine nanocareer for acute respiratory distress syndrome

    Grant number：23K24434  2022.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    赤星 朋比古, 村田 正治, 白水 和宏, 戸井田 力, 姜 貞勲

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    Grant type：Scientific research funding

    急性呼吸急迫症候群（Acute Respiratory Distress Syndrome: ARDS）は重篤な呼吸不全を来たす、致死率の高い重篤な疾患であるにも関わらず、根本的な治療法は未だにない。
    ARDSの病態には炎症が深く関わっており主に薬物療法としてはステロイドによる治療が試みられているが十分ではなく、スタチン製剤や好中球エラスターゼ阻害剤などの臨床試験では十分な有効生が示されていない。そこで、生体適合性の高いPS(ホスファチジルセリン)ナノキャリアを利用したIL-10PSナノキャリアのARDSの治療への可能性について検討することを目的とする。

    CiNii Research

  • 敗血症における急性腎障害の発症と慢性腎臓病への進展に関わるメカニズムの解明

    Grant number：22K09121  2022 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    牧 盾, 白水 和宏, 十時 崇彰, 東 みどり子, 松下 克之, 山浦 健

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    重症感染症では諸臓器の機能が障害されるが、腎臓は特に障害を受けやすい。急性の腎機能障害（急性腎障害）は感染症による死亡リスクを高め、慢性的な腎機能障害（慢性腎臓病）の原因になる。しかし感染症が腎障害を起こす機序は明らかでない。
    そこで、ハツカネズミに重症感染症を起こし、腎機能を測定する機械を取り付けて腎機能が低下する経過を調べる。また尿や血液中の物質を分析して、急性腎障害の原因物質を特定する。次に、摘出した腎臓にどのような変化が起きているのかを細胞レベルで調べる。
    それらの実験結果から、重症感染症による急性腎障害の発症と慢性腎臓病へ進展する機序を解明し、その予防や治療方法を開発する足がかりにする。

    CiNii Research

  • ホスファチジルセリンナノキャリアを用いた急性呼吸促拍症候群に対する治療法の開発

    Grant number：22H03175  2022 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    赤星 朋比古, 村田 正治, 白水 和宏, 戸井田 力, 姜 貞勲

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    急性炎症には主に薬物療法としてはステロイドによる治療が試みられているが、十分ではないのが現状である。これまでにもスタチン製剤や好中球エラスターゼ阻害剤なども臨床試験で試みられているが、未だに有効性が示されていない。そこで本研究では、生体適合性の高いナノ医薬を利用した免疫細胞の形質転換が、不可逆的な組織障害による機能不全を改善するのかどうかについて検証し、あらたな治療薬の創出を目指す。

    CiNii Research

  • 急性肝不全に対する硫化水素キノン酸化還元酵素(SQOR)の効果の検討

    Grant number：22K09097  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    白水 和宏, 赤星 朋比古

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    Authorship：Principal investigator  Grant type：Scientific research funding

    ・急性肝不全は未だに難治性の病態である。近年ウイルス性肝炎からの急性肝不全を発症する患者は減少傾向である一方、自己免疫性急性肝炎、非アルコール性脂肪肝炎が増加傾向にある。
    ・Concanavalin A(Con A)によって自己免疫性急性肝炎に類似した病態を誘発することができる。
    ・本申請研究では、Con Aによって引き起こされる急性肝不全モデルに対するSQORの効果を検証する。アデノ随伴ウイルスベクター (AAV)は肝臓に集積することが以前より広く知られており、SQORの過剰発現マウスを作成し、AAV-GFP(コントロール)とAAV-GFP-SQOR(過剰発現)の2群により検討する。

    CiNii Research

  • Investigating the Effects of Farnesylation on an Autoimmune Hepatitis Model

    Grant number：19K09374  2019 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Shirozu Kazuhiro

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    Authorship：Principal investigator  Grant type：Scientific research funding

    A mouse model of acute liver failure was created to demonstrate that the farnesyltransferase inhibitor studied as a therapeutic agent had a protective effect. Specifically, the study demonstrated that the inhibitor suppressed the elevation of liver enzymes caused by acute liver failure, suppressed the areas of necrosis in liver tissue, and suppressed the elevation of pro-inflammatory cytokines. As the mechanism of the inhibition, we proved that it inhibits the secretion of IFN-γ from CD4 Tcells by inhibiting the phosphorylation of STAT1 via CD4 Tcells.

    CiNii Research

  • 肝不全に対するファルネシルトランスフェラーゼ阻害薬及びスタチンの肝保護作用の検討

    Grant number：16K10963  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 薬剤性心筋障害に対して、硫化水素代謝物チオ硫酸は心筋保護効果を発揮するか？

    Grant number：16K10962  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 急性肝不全に対するファルネシルトランスフェラーゼ阻害薬の保護効果の検討

    Grant number：26893193  2014 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity start-up

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    Authorship：Principal investigator  Grant type：Scientific research funding

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Educational Activities

  • 医学部4年生の侵襲医学講義では手術室での感染対策・SSIに関しての講義、医学部５年生の臨床医学実習配置時のベッドサイド講義にて、麻酔全般の講義を担当している。医学部６年生のクリニカルクラークシップでは、より臨床的に、また臨床研究も交え、幅広く教育している。また、初期研修医、後期研修医への臨床麻酔、学会発表、論文作成指導も行っている。救急救命士の教育にも従事している。

Class subject

  • 侵襲医学　手術室環境と感染対策

    2023.4 - 2023.9   First semester

  • 手術室環境と感染対策

    2022.4 - 2023.3   Full year

  • 手術室環境と感染対策

    2021.4 - 2022.3   Full year

  • 局所麻酔、肺塞栓、偶発症

    2020.4 - 2021.3   Full year

  • 侵襲医学「手術室の感染対策」

    2020.4 - 2020.9   First semester

  • 侵襲医学「手術室の環境」

    2019.4 - 2019.9   First semester

  • 侵襲医学

    2015.4 - 2015.9   First semester

  • 肺塞栓、局所麻酔薬　、呼吸管理

    2014.4 - 2015.3   Full year

  • 呼吸管理について

    2011.4 - 2012.3   Full year

  • 呼吸管理について

    2010.4 - 2011.3   Full year

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FD Participation

  • 2019.10   Role：Participation   Title：OSCE評価者講習会

    Organizer：Undergraduate school department

Other educational activity and Special note

  • 2023  Special Affairs  支部周術期管理チームセミナー 「手術部位感染（SSI）を防ぐ」

    　詳細を見る

    支部周術期管理チームセミナー 「手術部位感染（SSI）を防ぐ」

  • 2019  Special Affairs  2019年第1回日本手術医学会教育セミナー　教育講演「体温管理の基礎から実践」

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    2019年第1回日本手術医学会教育セミナー　教育講演「体温管理の基礎から実践」

Outline of Social Contribution and International Cooperation activities

  • 学外講義（専門学校生、消防士向け）
    救急救命士の気管挿管実習

Activities contributing to policy formation, academic promotion, etc.

  • 2021.4 - 2023.3   日本麻酔科学会

    医薬品ガイドライン改定WG

  • 2021.4 - 2023.3   日本麻酔科学会

    評議員

  • 2021.4 - 2023.3   日本循環制御医学会

    代議員

  • 2021.4 - 2023.3   日本循環制御医学会

    学術誌 循環制御 編集委員

  • 2021.4 - 2023.3   日本麻酔科学会

    国際交流委員会

Travel Abroad

  • 2012.3 - 2014.2

    Staying countory name 1：United States   Staying institution name 1：Massachusetts general Hospital

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Anesthesiology and Resuscitation

Clinician qualification

  • Specialist

    Japanese Society of Anesthesiologists（JSA）

  • Specialist

    Japan Society of Pain Clinicians（JSPC）

  • Specialist

    日本集中治療学会、日本救急医学会

Year of medical license acquisition

  • 2002

Notable Clinical Activities

  • 日本麻酔科学会指導医として麻酔を含めた周術期管理の指導を若手医師に行っている。