Web of Science

記述言語：英語   出版者・発行元：Radiology  

Background: While current guidelines require lung ventilation-perfusion (V/Q) scanning as the first step to diagnose chronic pulmonary embolism in pulmonary hypertension (PH), its use may be limited by low availability and/or exposure to ionizing radiation. Purpose: To compare the performance of dynamic chest radiography (DCR) and lung V/Q scanning for detection of chronic thromboembolic PH (CTEPH). Materials and Methods: Patients with PH who underwent DCR and V/Q scanning in the supine position from December 2019 to July 2021 were retrospectively screened. The diagnosis of CTEPH was confirmed with right heart catheterization and invasive pulmonary angiography. Observer tests were conducted to evaluate the diagnostic accuracy of DCR and V/Q scanning. The lungs were divided into six areas (upper, middle, and lower for both) in the anteroposterior image, and the number of lung areas with thromboembolic perfusion defects was scored. Diagnostic performance was compared between DCR and V/Q scanning using the area under the receiver operating characteristic curve. Agreement between the interpretation of DCR and that of V/Q scanning was assessed using the Cohen kappa coefficient and percent agreement. Results: A total of 50 patients with PH were analyzed: 29 with CTEPH (mean age, 64 years ± 15 [SD]; 19 women) and 21 without CTEPH (mean age, 61 years ± 22; 14 women). The sensitivity, specificity, and accuracy of DCR were 97%, 86%, and 92%, respectively, and those of V/Q scanning were 100%, 86%, and 94%, respectively. Areas under the receiver operating characteristic curve for DCR and V/Q scanning were 0.92 (95% CI: 0.79, 0.97) and 0.93 (95% CI: 0.78, 0.98). Agreement between the consensus interpretation of DCR and that of V/Q scanning was substantial (κ = 0.79 [95% CI: 0.61, 0.96], percent agreement = 0.9 [95% CI: 0.79, 0.95]). Conclusion: Dynamic chest radiography had similar efficacy to ventilation-perfusion scanning in the detection of chronic thromboembolic pulmonary hypertension.

DOI： 10.1148/radiol.220908

Web of Science

Scopus

PubMed

記述言語：英語   出版者・発行元：Journal of Gastrointestinal Surgery  

Purpose: To evaluate the clinical significance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with pancreatic ductal adenocarcinoma who underwent neoadjuvant therapy. Methods: Among 285 consecutive patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma between 2015 and 2021, 86 who underwent preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography after completion of neoadjuvant treatment were reviewed. Among preoperative factors, including post-treatment maximum standardized uptake value, predictors of early recurrence and poor prognosis were identified using multivariate analysis for decision making in surgery. Results: Nineteen (22%) patients with pancreatic ductal adenocarcinoma demonstrated high maximum standardized uptake (≥ 4.5). High post-treatment maximum standardized uptake (≥ 4.5) predicted early recurrence within 6 months after surgery and correlated with shorter recurrence-free survival. Elevated post-treatment CA19-9 level (> 37 U/ml) and maximum standardized uptake ≥ 4.5 were independent prognostic factors. Post-treatment, a high maximum standardized uptake value indicated a poorer prognosis than a low maximum standardized uptake value in both patients with elevated CA19-9 and normal CA19-9 levels. The median overall survival in patients with elevated post-treatment CA19-9 and high maximum standardized uptake was only 17 months; 67% experienced early recurrence. Dynamic changes in maximum standardized uptake during neoadjuvant therapy were correlated with pathological response to neoadjuvant therapy, but not with radiological response or change in CA19-9 level. Conclusions: Post-treatment assessment using maximum standardized uptake value is useful for stratifying patients with pancreatic ductal adenocarcinoma who will benefit from surgery. Instead of subsequent curative resection, additional neoadjuvant therapy should be considered in patients with a persistently high maximum standardized uptake value.

DOI： 10.1007/s11605-023-05591-2

Web of Science

Scopus

PubMed

記述言語：英語   出版者・発行元：Anticancer Research  

Background/Aim: Differentiated thyroid cancer (DTC) has a good prognosis, except in the case of patients with radioiodine therapy (RIT)-refractory cancer. However, since DTC is essentially a slowly progressing cancer, it is usually judged to be a DTC with a poor prognosis after multiple RITs and yearly follow-up with echo, computed tomography (CT), and serum thyroglobulin values. This study investigated whether fluorodeoxyglucose-positron emission tomography/CT (FDG PET/CT) combined with initial RIT could identify early-stage patients with poor prognosis. Patients and Methods: We evaluated 100 patients with high-risk DTC who underwent total thyroidectomy and received RIT at our institution. We analyzed the clinical outcomes of patients and 18F-FDG accumulation using univariate and multivariate Cox proportional hazards regression models. Results: The 10-year overall survival (OS) was 87.9%, with no significant difference in OS between 18F-FDG accumulation at pre-total or near-total thyroidectomy (NTT) (p=0.180) and 131I accumulation at initial RIT (p=0.577). However, 18F-FDG positive patients had a significantly worse prognosis than negative patients (p=0.005) at initial RIT. Conclusion: 18F-FDG PET/CT plays an important role in both the diagnosis and prognostic prediction of RIT refractory disease in DTC patients. 18F-FDG PET/CT can be a useful tool particularly at the time of initial RIT since the 18F-FDG accumulation enables the screening of high-risk DTC with poor prognosis at a very early time stage.

DOI： 10.21873/anticanres.16148

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Scopus

PubMed

記述言語：英語   出版者・発行元：Clinical Radiology  

AIM: To determine whether the pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) can be predicted using 2-[18F]-fluoro-2-deoxy-D-glucose positron-emission tomography (F-18 FDG-PET). MATERIALS AND METHODS: Twenty-eight patients with PDAC who underwent only neoadjuvant chemotherapy (NAC) before surgery were enrolled in the study. All patients had F-18 FDG-PET examinations before NAC. The resected specimen was pathologically evaluated according to the Classification of Pancreatic Carcinoma (7th edn). Patients were categorised into a non-response group and a response group based on the pathological findings. The non-response group (Grades 1a and 1b) showed ≤50% necrosis in the specimen, while the specimens of the response group (Grades 2–3) showed >50% necrosis. The maximum standardised uptake values (SUVmax) of the tumours on F-18 FDG-PET were measured. The mean values of SUVmax were compared between the two groups. The diagnostic performance of SUVmax in distinguishing the two groups was also evaluated using receiver operating characteristic analysis. RESULTS: The mean SUVmax of the response group was higher than that of the non-response group (9.00 ± 1.78 versus 4.26 ± 2.35; p<0.001). The optimal cut-off value of SUVmax was 9.28 for distinguishing the two groups. The sensitivity, specificity, and accuracy for the prediction in the response group were 80%, 95.7%, and 92.9%, respectively. CONCLUSIONS: SUVmax on F-18 FDG-PET may be useful as a biomarker to predict the pathological response to NAC in patients with PDAC.

DOI： 10.1016/j.crad.2022.03.001

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Scopus

PubMed

記述言語：英語   出版者・発行元：Annals of Nuclear Medicine  

Objective: 123I metaiodobenzylguanidine (MIBG) scintigraphy is a useful tool for the diagnosis of pheochromocytomas (PHEOs), but some PHEOs are difficult to differentiate from cortical adenoma (CA) or normal adrenal uptake by visual evaluation alone. A new semi-quantitative analysis using 123I MIBG SPECT/CT is thus expected. Herein, we introduce the tumor-to-liver count ratio (T/L) and the tumor-to-muscle count ratio (T/M). Methods: We examined the cases of 21 patients with PHEOs (10 males, 11 females; age 24–80, median 61 years) and 23 patients with CA (15 males and 8 females, age 30–78, median 58 years). The visual scoring based on 123I MIBG planar images (planar score) and SPECT images (SPECT score) was used as the conventional evaluation. Using 123I MIBG SPECT/CT findings, we calculated the semi-quantitative values of the count ratio using the maximum or mean count of the tumor and the liver or muscle as the reference organ (T/Lmax, T/Lmean, T/Mmax and T/Mmean). Each evaluation of the PHEOs and CAs was compared, and the diagnosing performance was evaluated based on an ROC analysis. Results: The area under curve (AUC) values were as follows: the planar score, 0.833; SPECT score, 0.813; T/Lmax, 0.986; T/Lmean, 0.975; T/Mmax, 0.955; and T/Mmean, 0.933. The AUC for T/Mmax was significantly higher than those of the planar score, and SPECT score by ROC analysis (p < 0.01 each). Conclusion: The semi-quantitative value of 123I MIBG SPECT/CT is more useful than the conventional visual evaluation for differentiating PHEOs from CAs.

DOI： 10.1007/s12149-021-01690-9

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Scopus

PubMed

記述言語：英語   出版者・発行元：(一社)日本核医学会  

2011年1月～2015年2月までの期間内に、当院で123I MIBG SPECT/CT検査を受けた、褐色細胞腫(PHEO)患者21例(男性10例、女性11例、年齢24～80歳)と、副腎皮質腺腫(CA)患者23例(男性15例、女性8例、年齢30～78歳)を対象に調査した。123Iメタヨードベンジルグアニジン(MIBG) SPECT/CT所見から、腫瘍と肝臓へ集積最大値の比(T/Lmax)、腫瘍と肝臓への集積平均値の比(T/Lmean)、腫瘍と骨格筋への集積最大値の比(T/Mmax)、腫瘍と骨格筋への集積平均値の比(T/Mmean)について、半定量的に解析した。その結果、ROC解析によるAUCでは、123I MIBGのプラナー画像の視覚スコアが0.833、SPECT画像の視覚スコアが0.813で、T/Lmaxが0.986、T/Lmeanが0.975、T/Mmaxが0.955、T/Mmeanが0.933であった。なかでも、T/MmaxのAUCでは、123I MIBGのプラナー画像の視覚スコアや、SPECT画像の視覚スコアに比べ、有意に高値が検出された。以上の解析結果から、PHEOとCAの鑑別に、123I MIBG SPECT/CTによる半定量分析が有用と判断された。

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Introduction: Radioiodine therapy with ¹³¹I (¹³¹I therapy) after total or near-total thyroidectomy has been established as an effective treatment for Differentiated Thyroid Carcinoma (DTC), but can induce dry mouth symptoms by salivary gland damage and impair the patients’ quality of life. Aim: To propose a functional scoring system based on Salivary Gland Scintigraphy (SGS) findings that evaluates development of salivary gland dysfunction secondary to ¹³¹I therapy in patients with DTC. Materials and Methods: This retrospective study evaluated the records of 279 DTC patients who underwent SGS after one or more round(s) of ¹³¹I therapy, using 370 MBqof ^99mTc-pertechnetate. The SGS results were assessed using a novel functional scoring system in the Parotid Glands (PGs) and Submandibular Glands (SMGs) according to visual evaluations based on a three-point uptake score, Washout Rate (%WR) score after lemon-juice stimulation, and functional score. The scores were compared among pretreatment, low-dose (<10 GBq), and high-dose (>10 GBq) groups and among pretreatment, symptom-positive, and symptom-negative groups. Risk factors for dry mouth were analyzed by univariate and multivariate logistic regression analyses. Results: Dry mouth symptoms developed in 15.4% of the DTC patients after ¹³¹I therapy. The three-point uptake, %WR, and functional scores in both the PG and SMG were statistically significant between low-dose and high-dose groups, and between symptom-positive and symptom-negative groups. The PG/SMG functional scores were independent risk factors for dry mouth (odds ratio, 0.03 and 0.0007 respectively). Conclusion: SGS-based PG and SMG functional scores were effective biomarkers to objectively evaluate salivary gland dysfunction, with the high strength of association with dry mouth symptoms.

DOI： 10.7860/JCDR/2017/27340.10431

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: Lung metastases (LMs) and their radioiodine uptake affect prognosis in patients with differentiated thyroid carcinoma (DTC). We herein investigate the value of metabolic tumor volume (MTV) in LMs on positron emission tomography/computed tomography (PET/CT) using 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18 FDG PET/CT) in predicting short-term progression after initial I-131 therapy in DTC patients. Materials and Methods: We retrospectively evaluated 111 DTC patients with LMs. Diagnostic CT and I-131 scintigraphy were performed within 1 week of I-131 therapy. Maximum standardized uptake value (SUVmax) and total MTV (MTVtotal) were compared between patients with I-131-positive and I-131-negative LMs and between patients with and without short-term progression. Correlation analyses were performed between F-18 FDG PET/CT parameters and thyroglobulin (TG) level, and predictive factors for short-term progression were analyzed by logistic regression and receiver operating characteristic curve analysis.Results: Patients with short-term progression had significantly higher SUVmax and MTVtotal than those without. TG levels were significantly correlated with SUVmax (r = 0.21) and MTVtotal (r = 0.51) after I-131 therapy. MTVtotal showed significant association (χ² = 16.5, odds ratio = 0.02) with short-term progression after initial I-131 therapy and had the highest predictive value of all the putative risk factors. Conclusions: MTVtotal in LMs on F-18 FDG PET/CT is an independent predictive factor with a high predictive value for short-term progression of DTC after initial I-131 therapy. It is recommended that F-18 FDG PET/CT be performed before planning therapy during the evaluation of DTC patients with LM.

DOI： 10.4103/ijnm.IJNM_43_17

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective Balloon pulmonary angioplasty (BPA) is used for inoperable chronic thromboembolic pulmonary hypertension (CTEPH), but its effect cannot be evaluated noninvasively. We devised a noninvasive quantitative index of response to BPA using three-dimensional fractal analysis (3D-FA) of technetium-99m-macroaggregated albumin (99m Tc-MAA) single-photon emission computed tomography (SPECT). Patients and methods Forty CTEPH patients who underwent pulmonary perfusion scintigraphy and mean pulmonary arterial pressure (mPAP) measurement by right heart catheterization before and after BPA were studied. The total uptake volume (TUV) in bilateral lungs was determined from maximum intensity projection 99m Tc-MAA SPECT images. Fractal dimension was assessed by 3D-FA. Parameters were compared before and after BPA, and between patients with post-BPA mPAP more than 30 mmHg and less than or equal to 30 mmHg. Receiver operating characteristic analysis was carried out. Results BPA significantly improved TUV (595±204-885±214 ml, P<0.001) and reduced the laterality of uptake (238±147-135±131 ml, P<0.001). Patients with poor therapeutic response (post-BPA mPAP≥30 mmHg, n=16) showed a significantly smaller TUV increase (P=0.044) and a significantly greater post-BPA fractal dimension (P<0.001) than the low-mPAP group. Fractal dimension correlated with mPAP values before and after BPA (P=0.013 and 0.001, respectively). A post-BPA fractal dimension threshold of 2.4 distinguished between BPA success and failure with 75% sensitivity, 79% specificity, 78% accuracy, and area under the curve of 0.85. Conclusion 3D-FA using 99m Tc-MAA SPECT pulmonary perfusion scintigraphy enables a noninvasive evaluation of the response of CTEPH patients to BPA.

DOI： 10.1097/MNM.0000000000000673

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND AND PURPOSE: Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based (18)F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs.
MATERIALS AND METHODS: We retrospectively reviewed 27 patients with PMSTs and calculated SUVmax, MTV, and total lesion glycolysis (TLG) to compare their accuracy in predicting progression-free survival (PFS) and overall survival (OS) by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were used to compare the reliability of the metabolic parameters and various clinical factors.
RESULTS: MTV exhibited greater accuracy than SUVmax or TLG. The cut-off values for PFS and OS derived from the AUC data were MTV 45 ml and 83 ml and TLG 250 SUV⁎ml and 257 SUV⁎ml, respectively. MTV above cut-off value, but not TLG, was identified as significant prognostic factor for PFS by log-lank test (p = 0.04). In addition, MTV was the only significant predictive factors for PFS and OS in the multivariate analysis.
CONCLUSIONS: MTV was a more accurate predictor of PFS and OS in PMSTs compared to TLG or SUVmax and helped decision-making for guiding rational treatment options.

DOI： 10.1155/2017/8132676

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: To evaluate the diagnostic performance of intravoxel incoherent motion (IVIM) MR imaging and ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) in differentiating primary central nervous system lymphoma (PCNSL) from glioblastoma multiforme (GBM). Materials and Methods: Fifty patients, 17 with PCNSL and 33 with GBM, were retrospectively studied. From the 3 Tesla IVIM data, the perfusion fraction (f) and diffusion coefficient (D) were obtained. In addition, the maximum standard uptake value (SUV_max) was obtained from the FDG-PET data. Each of the three parameters was compared between PCNSL and GBM using Mann-Whitney U-test. The performance in discriminating between PCNSL and GBM was evaluated using receiver-operating characteristics analysis and area-under-the-curve (AUC) values for the three parameters. Results: The f_max and D_min values were significantly higher in GBM than in PCNSL (P < 0.01 and P < 0.0001, respectively). In addition, the SUV_max value was significantly lower in GBM than in PCNSL (P < 0.0005). The AUC values for f_max, D_min, and SUV_max were 0.756, 0.905, and 0.857, respectively. The combination of the f_max and D_min increased the diagnostic performance (AUC = 0.936) of f_max (P < 0.05), but this value was not significantly different from the values for D_min (P = 0.30). Conclusion: IVIM-MR imaging noninvasively provides useful quantitative information in distinguishing between PCNSL and GBM. J. Magn. Reson. Imaging 2016;44:1256–1261.

DOI： 10.1002/jmri.25261

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objectives: Radioiodine therapy is an effective treatment for lung metastasis from thyroid cancer. However, cases of lung metastasis without iodine uptake are often encountered. In such cases, FDG accumulation in lung lesions is often observed. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called “flip-flop” phenomenon. The aim of this study was to assess the relationship between patient age and the occurrence of the flip-flop phenomenon. Methods: Eighty-six patients who underwent radioiodine therapy for lung metastasis were studied retrospectively (age 17–73 years; median 60 years; males:females 22:64). We compared the clinical data and imaging findings (size and FDG uptake of lung nodules) between patients with (n = 44) and without (n = 42) iodine uptake in lung metastasis. Results: Significantly more young patients showed iodine accumulation in lung metastasis than old patients (p = 0.0025). Lung metastases with larger size or greater FDG uptake showed no iodine uptake more frequently with significant difference (p = 0.015 and <0.001, respectively). Among patients with FDG uptake in the lung metastasis, 57.1 % of young patients (<60 years) and 24.3 % of the old patients (≥60 years) showed iodine uptake (p = 0.0029). Conclusions: Higher patient age and lung nodules with large size or FDG accumulation are negative factors for iodine accumulation in lung metastases from thyroid cancer. In addition, our results show that young patients have a greater likelihood of iodine uptake even when FDG accumulates in lung metastasis, in contrast to old patients.

DOI： 10.1007/s12149-016-1104-9

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVES:
BONENAVI, a computer-aided diagnostic system, is used in bone scintigraphy. This system provides the artificial neural network (ANN) and bone scan index (BSI) values. ANN is associated with the possibility of bone metastasis, while BSI is related to the amount of bone metastasis. The degree of uptake on bone scintigraphy can be affected by the type of bone metastasis. Therefore, the ANN value provided by BONENAVI may be influenced by the characteristics of bone metastasis. In this study, we aimed to assess the relationship between ANN value and characteristics of bone metastasis.
METHODS:
We analyzed 50 patients (36 males,14 females; age range: 87-42 yrs median age:72.5 yrs) with prostate, breast, or lung cancer who had undergone bone scintigraphy and were diagnosed with bone metastasis (32 cases of prostate cancer, nine cases of breast cancer, and nine cases of lung cancer). Those who had received systematic therapy over the past years were excluded. Bone metastases were diagnosed clinically, and the type of bone metastasis (osteoblastic, mildly osteoblastic, osteolytic, and mixed components) was decided visually by the agreement of two radiologists. We compared the ANN values (case-based and lesion-based) among the three primary cancers and four types of bone metastasis.
RESULTS:
There was no significant difference in case-based ANN values among prostate, breast, and lung cancers. However, the lesion-based ANN values were the highest in cases with prostate cancer and the lowest in cases of lung cancer (median values: prostate cancer, 0.980; breast cancer 0.909; and lung cancer, 0.864). Mildly osteoblastic lesions showed significantly lower ANN values than the other three types of bone metastasis (median values: osteoblastic,; 0.939 mildly osteoblastic; 0.788, mixed type; 0.991, and osteolytic. 0.969) The possibility of a lesion-based ANN value below 0.5 was %10.9 for bone metastasis in prostate cancer, %12.9 for breast cancer, and %37.2 for lung cancer. The corresponding possibility were %14.7 for osteoblastic metastases, %23.9 for mildly osteoblastic metastases, %7.14 for mixed-type metastases, and %16.0 for osteolytic metastases.
CONCLUSION:
The lesion-based ANN values calculated by BONENAVI can be influenced by the type of primary cancer and bone metastasis.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

MUTYH is a DNA glycosylase that excises adenine paired with 8-oxoguanine to prevent mutagenesis in mammals. Biallelic germline mutations of MUTYH have been found in patients predisposed to a recessive form of familial adenomatous polyposis (MAP: MUTYH-associated polyposis). We previously reported that Mutyh-deficient mice showed a high susceptibility to spontaneous and oxidative stress-induced intestinal adenoma/carcinoma. Here, we performed mutation analysis of the tumor-associated genes including Apc, Ctnnb1, Kras and Trp53 in the intestinal tumors of Mutyh-deficient mice. In the 62 tumors, we identified 25 mutations in Apc of 18 tumors and 36 mutations in Ctnnb1 of 36 tumors. Altogether, 54 out of the 62 tumors (87.1%) had a mutation in either Apc or Ctnnb1; no tumor displayed mutations simultaneously in the both genes. Similar to MAP, 60 out of 61 mutations (98.3%) were identified as G:C to T:A transversions of which 85% occurred at either AGAA or TGAA sequences. Immunohistochemical analyses revealed the accumulation of β-catenin in the nuclei of tumors. No mutation was found in either Kras or Trp53 in the tumors. These results indicate that the uncontrolled activation of Wnt signaling pathway is causatively associated with oxidative stress-induced intestinal tumorigenesis in the Mutyh-deficient mice.

DOI： 10.7150/ijbs.9241. eCollection 2014.

記述言語：英語  

開催年月日： 2020年5月 - 2021年5月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：New Orleans, LA (Virtual)   国名：アメリカ合衆国  

開催年月日： 2020年2月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：佐賀市   国名：日本国  

開催年月日： 2019年6月

記述言語：日本語  

国名：アメリカ合衆国  

開催年月日： 2019年6月

記述言語：日本語  

国名：日本国  

開催年月日： 2018年7月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：サンディエゴ   国名：アメリカ合衆国  

Objectives: The impairment of salivary glands is one of the major complications after radioiodine therapy (RIT) for thyroid cancer. In this study, we investigated whether the disorder of salivary glands after RIT can be predicted with iodine uptake in salivary glands at RIT. Methods: Forty patients who received the first radioiodine therapy for thyroid cancer from Jan. 2013 to Aug. 2014 and had the salivary gland scintigraphy before one year after the RIT were included (Age: 25–73 y.o., Median: 56.5 y.o., M : F = 14 : 26). All patients had total thyroidectomy. Nine patients received rhTSH injections before RIT and 31 patients had 4 weeks of thyroid hormone cessation. All patients had 2 weeks of iodine-free diet. The salivary gland scintigraphy with 99mTc- was performed just before and one year after the first RIT. The impairment of salivary gland was analyzed by comparing the salivary gland scintigraphy before and one year after RIT. Uptake of iodine-131 in salivary glands was evaluated with iodine scintigraphy performed 5 or 6 days after iodine-131 administration. The ratio of patients who showed the decreased uptake or the diminished response to stimulation of secretion on the salivary gland scintigraphy was compared between the patients with and without iodine uptake in the salivary glands. χ square test was used for statistical analysis. p < 0.05 was considered as statistically significant. Results: In total, 22 out of 40 patients (55.0%) who received the RIT showed the impairment of salivary glands. Ten out of the 15 patients (66.7%) with iodine uptake in salivary gland showed the impairment of salivary glands one year after the RIT, while 8 out of 25 patients (32.0%) without iodine uptake in salivary glands did (p = 0.033). Conclusions: The patients who showed iodine uptake on iodine scintigraphy at RIT had salivary glands disorder more frequently compared to those who did not.

開催年月日： 2017年7月 - 2018年7月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

悪性リンパ腫のFDG—PET評価でDeauville 5-point score (5-PS)が広く用いられている。小児では肝集積が低いため、この判定法をそのまま当てはめることは難しい。本研究では肝集積と年齢の関係を解析し、Deauville 5-PSへの影響を検証した。【方法】55名の肝のSUVmaxを測定し、11群(0-3、4-6、7-9、10-12、13-15、16-18、19-21、22-24、25-29、30-34、35-39歳)の間で比較した。【結果】肝のSUVmaxの平均値は0-4歳：0.96、4-6歳：1.2、7-19歳：1.6、10-12歳：2.1、13-15歳：2.5、16-18歳：2.9、19-21歳：3.2、22-24歳：3.2、25-29歳：3.3、30-34歳：3.2、35-39歳：3.2であった。【結論】肝のFDG集積は18歳以下の群で低く、Deauville 5-PSでは、治療の対象となるスコア4以上に過大評価される可能性がある。

開催年月日： 2015年3月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：Wien   国名：オーストラリア連邦  

FDG avid thyroid cancer lesions accumulate radioiodine with lower frequency, which is so called flip-flop phenomenon. The aim of this study was to analyze the impact of patient age to flip-flop phenomenon in the metastasized pulmonary lesions. Methods: The cases of 75 patients who had radioiodine therapy for lung metastasis were studied retrospectively (age 17–73 yrs, median: 60 yrs; males : females, 22 : 53). We analyzed the relationship between the absence of iodine uptake and FDG avidity in the metastasized pulmonary lesions and compared the result between the two groups (age ≧ 60 yrs vs. age < 60 yrs). Results: In younger patients (< 60 yrs), 7 out of 14 patients (50%) with FDG avid lung metastasis showed iodine uptake in the pulmonary lesion. On the other hand, 7 out of 30 patients (23.3%) with FDG avid lung metastasis showed pulmonary uptake in the older patients (≧ 60 yrs). Conclusions: Our results show that the influence of FDG avidity to iodine uptake in the lung metastasis is varied depending on the patient age and younger patients with FDG avid lung metastasis still have the chance for a successful radioiodine therapy. Therefore, it is suggested that radioiodine therapy should be performed for the young patients even when their pulmonary lesions show FDG uptake.

開催年月日： 2014年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：大阪   国名：日本国  

甲状腺癌病変にFDG集積を認める場合に放射性ヨウ素が集積し難いことは、いわゆるflip-flop 現象として知られている。これまでリンパ節や肺病変でこの現象を確認した。本研究では骨病変で解析した。【方法】甲状腺癌骨転移に対し放射性ヨウ素内用療法を施行し、同時期にFDG-PETを撮影した患者10名(男：女＝4：6、29-70歳、中央値；56.5歳)、77病変を対象とした。ヨウ素集積の有無とFDG集積程度を比較した。【結果】8例で骨転移巣にヨウ素の集積を認めた。ヨウ素集積を認めた病変でも比較的高いFDG集積を示した(SUVmax中央値；4.68)。高いFDG集積(SUVmax＞5)を示す病変も26病変(43.2%)認めた。ヨウ素集積の無い病変(SUVmax中央値；9.30)は、ヨウ素集積のあった病変に比し、有意に高いFDG異常集積を示した(p＜0.00001)。【結論】骨転移においてもヨウ素集積を認めない病変が認める病変に比し高いFDG集積を示すが、高いFDG集積を認めても、骨転移では比較的高い頻度でヨウ素集積を認める。

開催年月日： 2014年6月

記述言語：英語   会議種別：口頭発表（一般）  

開催地：ST. LOUIS   国名：アメリカ合衆国  

Objectives: BONENAVI is a computer aided diagnostic system on bone scintigraphies, which provides quantitative parameters such as artificial neural networks (ANN) and bone scan index (BSI); ANN and BSI are parameters related to the possibility and amount of bone metastases, respectively. In this study, we assessed the diagnostic performance of BONENAVI by comparing the accuracy in diagnosing bone metastases among segmented regions such as spine and ribs, and also analyzed the influence from the type of bone metastasis (osteolytic or osteoblastic) on the ANN value. Methods: Fifty-three patients who undergone bone scintigraphy and were diagnosed with bone metastases were includes (Age: 33–87 y.o., Median: 69 y.o., M : F = 33 : 20). Bone metastases were diagnosed clinically using the following modalities; bone scintigraphy, CT, FDG-PET and MRI. Diagnostic performance of BONENAVI was evaluated on the basis of each segmented region such as skull, spine (cervical, thoracic and lumbar), clavicle, scapula, rib, sternum, humerus, pelvic bone, sacrum and femur by comparing ANN value and clinical diagnosis. The lesions of bone metastases were classified into 3 groups depending on the ratio of osteolytic and osteoblastic areas; osteolytic, osteoblastic and intermediate type, then ANN value of the lesions was compared among the 3 groups using Mann-Whitney U test for statistical analysis. Results; Diagnostic performance of BONENAVI was high in thoracic spine, humerus, rib and femur but low in skull, cervical spine, scapula and sternum when comparing the accuracy. Osteoblastic lesions showed significantly higher ANN value than osteolytic lesions (Median; 0.703 vs. 0.974, p = 0.029) and 3 out of 15 osteolytic lesions were misdiagnosed. Conclusion: Diagnostic performance of BONENAVI varied depending on the regions where bone metastases occurred. Osteolytic lesions were sometimes misdiagnosed. We need to take account of these tendencies when diagnosing bone metastases with BONENAVI.

記述言語：英語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：英語  

記述言語：日本語  

記述言語：日本語