TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells Reviewed International journal

Yoshikane Kikushige, Takahiro Shima, Shin-ichiro Takayanagi, Shingo Urata, Toshihiro Miyamoto, Hiromi Iwasaki, Katsuto Takenaka, Takanori Teshima, Toshiyuki Tanaka, Yoshimasa Inagaki, Koichi Akashi

Cell Stem Cell   7   2010.12

Autologous HSCT with novel agent-based induction and consolidation followed by lenalidomide maintenance for untreated multiple myeloma. Reviewed International journal

Mori Y, Takizawa J, Katsuoka Y, Takezako N, Nagafuji K, Handa H, Kuroda J, Sunami K, Kamimura T, Ogawa R, Kikushige Y, Harada M, Akashi K, Miyamoto T,

Cancer Science   2024.3

Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation Invited Reviewed International journal

Sugio, T., Uchida, N., Miyawaki, K., Ohno, Y., Eto, T., Mori, Y., Yoshimoto, G., Kikushige, Y., Kunisaki, Y., Mizuno, S., Nagafuji, K., Iwasaki, H., Kamimura, T., Ogawa, R., Miyamoto, T., Taniguchi, S., Akashi, K. & Kato, K.

Bone Marrow Transplant   2024.3

Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drugs-induced thromboembolism. Blood Adv. Reviewed International journal

Hatakeyama, K., Kikushige, Y.*, Ishihara, D., Yamamoto, S., Kawano, G., Tochigi, T., Miyamoto, T., Sakoda, T., Christoforou, A., Kunisaki, Y., Fukata, M., Kato, K., Ito, T., Handa, H. & Akashi, K.

Blood Advances   2024.1

POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. Reviewed International journal

Nakashima, K., Kunisaki, Y., Hosokawa, K., Gotoh, K., Yao, H., Yuta, R., Semba, Y., Nogami, J., Kikushige, Y., Stumpf, P.S., MacArthur, B.D., Kang, D., Akashi, K., Ohga, S. & Arai, F.

Commun Biol   2023.10

Nakano, M., Taguchi, R., Kikushige, Y*., Isobe, T., Miyawaki, K., Mizuno, S., Tsuruta, N., Hanamura, F., Yamaguchi, K., Yamauchi, T., Ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Kuo, C.J., Baba, E*. & Akashi, K. Reviewed International journal

RHAMM marks proliferative subpopulation of human colorectal cancer stem cells

Cancer Science   2023.8

GPAM mediated lysophosphatidic acid synthesis regulates mitochondrial dynamics in acute myeloid leukemia Reviewed International journal

Irifune, H., Kochi, Y., Miyamoto, T., Sakoda, T., Kato, K., Kunisaki, Y., Akashi, K. & Kikushige, Y.

Cancer Sciences   2023.4

RHAMM marks proliferative subpopulation of human colorectal cancer stem cells Reviewed International journal

Nakano, M., Taguchi, R., Kikushige, Y*., Isobe, T., Miyawaki, K., Mizuno, S., Tsuruta, N., Hanamura, F., Yamaguchi, K., Yamauchi, T., Ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Kuo, C.J., Baba, E*. & Akashi, K

CANCER SCIENCE   2023.3

Successful pseudo-autologous stem cell transplantation for donor-derived Burkitt lymphoma occurring 9 years after allogeneic transplantation Reviewed International journal

Taniguchi, S., Utsumi, S., Kochi, Y., Taya, Y., Mori, Y., Semba, Y.I., Sugio, T., Miyawaki, K., Kikushige, Y., Kunisaki, Y., Yoshimoto, G., Numata, A., Kato, K., Uchida, N., Maeda, T., Miyamoto, T., Taniguchi, S. & Akashi, K

INTERNATIONAL JOURNAL OF HEMATOLOGY   117 ( 2 )   287 - 292   2023.2

TIM-3 signaling hijacks the canonical Wnt/beta-catenin pathway to maintain cancer stemness in acute myeloid leukemia Reviewed International journal

Sakoda, T., Kikushige, Y*., Miyamoto, T., Irifune, H., Harada, T., Hatakeyama, K., Kunisaki, Y., Kato, K. & Akashi, K.

Blood Advances   2023.1

Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance Reviewed International journal

Nakao, F., Setoguchi, K., Semba, Y., Yamauchi, T., Nogami, J., Sasaki, K., Imanaga, H., Terasaki, T., Miyazaki, M., Hirabayashi, S., Miyawaki, K., Kikushige, Y., Masuda, T., Akashi, K. & Maeda, T.

Leukemia   2023.1

TET2 Clonal Hematopoiesis Is Associated With Anthracycline-Induced Cardiotoxicity in Patients With Lymphoma Reviewed International journal

Hatakeyama, K., Hieda, M., Semba, Y., Moriyama, S., Wang, Y., Maeda, T., Kato, K., Miyamoto, T., Akashi, K. & Kikushige, Y*

JACC CardioOncol   2022.10

Prognostic value of pre-transplantation total metabolic tumor volume on (18)fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography in relapsed and refractory aggressive lymphoma Reviewed International journal

Sugio, T., Baba, S., Mori, Y., Yoshimoto, G., Kamesaki, K., Takashima, S., Urata, S., Shima, T., Miyawaki, K., Kikushige, Y., Kunisaki, Y., Numata, A., Takenaka, K., Iawasaki, H., Miyamoto, T., Ishigami, K., Akashi, K. & Kato, K

INTERNATIONAL JOURNAL OF HEMATOLOGY   116 ( 4 )   603 - 611   2022.10

Risk factors for late cytomegalovirus infection after completing letermovir prophylaxis Reviewed International journal

Mori, Y., Harada, T., Yoshimoto, G., Shima, T., Numata, A., Jinnouchi, F., Yamauchi, T., Kikushige, Y., Kunisaki, Y., Kato, K., Takenaka, K., Akashi, K. & Miyamoto, T.

INTERNATIONAL JOURNAL OF HEMATOLOGY   116 ( 2 )   258 - 265   2022.8

Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions. Reviewed International journal

Ito, M., Nakano, M., Ariyama, H., Yamaguchi, K., Tanaka, R., Semba, Y., Sugio, T., Miyawaki, K., Kikushige, Y., Mizuno, S., Isobe, T., Tanoue, K., Taguchi, R., Ueno, S., Kawano, T., Murata, M., Baba, E. & Akashi, K.

Cancer Lett,   2022.3

A germinal center-associated microenvironmental signature reflects malignant phenotype and outcome of DLBCL Reviewed International journal

Miyawaki, K., Kato, K., Sugio, T., Sasaki, K., Miyoshi, H., Semba, Y., Kikushige, Y., Mori, Y., Kunisaki, Y., Iwasaki, H., Miyamoto, T., Kuo, F.C., Aster, J.C., Ohshima, K., Maeda, T. & Akashi, K.

Blood Advances   2021.12

TIM-3 in normal and malignant hematopoiesis: Structure, function, and signaling pathways. Invited Reviewed International journal

Yoshikane Kikushige

Cancer Science   2021.6

Pathogenesis of chronic lymphocytic leukemia and the development of novel therapeutic strategies. Invited Reviewed International journal

Yoshikane Kikushige

J Clin Exp Hematop.   ( 60 )   146 - 158   2020.12

Generation of a novel CD30 + B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis Reviewed International journal

Kazuhiko Higashioka, Yoshikane Kikushige, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Makoto Kikukawa, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro

Clinical & Experimental Immunology   201 ( 3 )   233 - 243   2020.9

Pathophysiology of chronic lymphocytic leukemia and human B1 cell development Invited Reviewed

Yoshikane Kikushige

International journal of hematology   111 ( 5 )   634 - 641   2020.5

TKIs Induce Alternative Spliced BCR-ABL Ins35bp Variant via Inhibition of RNA Polymerase Ⅱ on Genomic BCR-ABL Reviewed International journal

2020.4

A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells Reviewed International journal

Fumiaki Jinnouchi, Takuji Yamauchi, Ayano Yurino, Takuya Nunomura, Michitaka Nakano, Chika Iwamoto, Teppei Obara, Kohta Miyawaki, Yoshikane Kikushige, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Eishi Baba, Koichi Akashi, Katsuto Takenaka

Blood   2020.3

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer Reviewed

Michitaka Nakano, Yoshikane Kikushige, Kohta Miyawaki, Yuya Kunisaki, Shinichi Mizuno, Katsuto Takenaka, Shingo Tamura, Yuta Okumura, Mamoru Ito, Hiroshi Ariyama, Hitoshi Kusaba, Masafumi Nakamura, Takahiro Maeda, Eishi Baba, Koichi Akashi

Oncogene   38 ( 6 )   780 - 793   2019.2

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer Reviewed

Michitaka Nakano, Yoshikane Kikushige, Kohta Miyawaki, Yuya Kunisaki, Shinichi Mizuno, Katsuto Takenaka, Shingo Tamura, Yuta Okumura, Mamoru Ito, Hiroshi Ariyama, Hitoshi Kusaba, Masafumi Nakamura, Takahiro Maeda, Eishi Baba, Koichi Akashi

Oncogene   38 ( 6 )   780 - 793   2019.2

Anti-GPRC5D/CD3 bispecific T-cell-redirecting antibody for the treatment of multiple myeloma Reviewed

Tatsushi Kodama, Yu Kochi, Waka Nakai, Hideaki Mizuno, Takeshi Baba, Kiyoshi Habu, Noriaki Sawada, Hiroyuki Tsunoda, Takahiro Shima, Kohta Miyawaki, Yoshikane Kikushige, Yasuo Mori, Toshihiro Miyamoto, Takahiro Maeda, Koichi Akashi

Molecular Cancer Therapeutics   18 ( 9 )   1555 - 1564   2019.1

Anti-GPRC5D/CD3 bispecific T-cell-redirecting antibody for the treatment of multiple myeloma Reviewed

Tatsushi Kodama, Yu Kochi, Waka Nakai, Hideaki Mizuno, Takeshi Baba, Kiyoshi Habu, Noriaki Sawada, Hiroyuki Tsunoda, Takahiro Shima, Kohta Miyawaki, Yoshikane Kikushige, Yasuo Mori, Toshihiro Miyamoto, Takahiro Maeda, Koichi Akashi

Molecular Cancer Therapeutics   18 ( 9 )   1555 - 1564   2019.1

Human Herpes Virus-6–Associated Encephalitis/Myelitis Mimicking Calcineurin Inhibitor–Induced Pain Syndrome in Allogeneic Stem Cell Transplantation Recipients Reviewed

24 ( 12 )   2540 - 2548   2018.12

Human Herpes Virus-6–Associated Encephalitis/Myelitis Mimicking Calcineurin Inhibitor–Induced Pain Syndrome in Allogeneic Stem Cell Transplantation Recipients Reviewed

24 ( 12 )   2540 - 2548   2018.12

E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG Reviewed

Shingo Tamura, Taichi Isobe, Hiroshi Ariyama, Michitaka Nakano, Yoshikane Kikushige, Shigeo Takaishi, Hitoshi Kusaba, Katsuto Takenaka, Takashi Ueki, Masafumi Nakamura, Koichi Akashi, Eishi Baba

Oncology reports   40 ( 2 )   693 - 703   2018.8

E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG Reviewed

Shingo Tamura, Taichi Isobe, Hiroshi Ariyama, Michitaka Nakano, Yoshikane Kikushige, Shigeo Takaishi, Hitoshi Kusaba, Katsuto Takenaka, Takashi Ueki, Masafumi Nakamura, Koichi Akashi, Eishi Baba

Oncology reports   40 ( 2 )   693 - 703   2018.8

Identification of unipotent megakaryocyte progenitors in human hematopoiesis Reviewed

Kohta Miyawaki, Hiromi Iwasaki, Takashi Jiromaru, Hirotake Kusumoto, Ayano Yurino, Takeshi Sugio, Yasufumi Uehara, Jun Odawara, Shinya Daitoku, Yuya Kunisaki, Yasuo Mori, Yojiro Arinobu, Hirofumi Tsuzuki, Yoshikane Kikushige, Tadafumi Iino, Koji Kato, Katsuto Takenaka, Toshihiro Miyamoto, Takahiro Maeda, Koichi Akashi

Blood   129 ( 25 )   3332 - 3343   2017.6

Mobilization of human immature hematopoietic progenitors through combinatory use of bortezomib and immunomodulatory drugs Reviewed

Taro Tochigi, Takatoshi Aoki, Yoshikane Kikushige, Tomohiko Kamimura, Yoshikiyo Ito, Takahiro Shima, Takuji Yamauchi, Yasuo Mori, Goichi Yoshimoto, Kenjiro Kamezaki, Koji Kato, Katsuto Takenaka, Hiromi Iwasaki, Koichi Akashi, Toshihiro Miyamoto

International journal of hematology   105 ( 4 )   423 - 432   2017.4

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit^Wv Mutations Reviewed

Ayano Yurino, Katsuto Takenaka, Takuji Yamauchi, Takuya Nunomura, Yasufumi Uehara, Fumiaki Jinnouchi, Kohta Miyawaki, Yoshikane Kikushige, Koji Kato, Toshihiro Miyamoto, Hiromi Iwasaki, Yuya Kunisaki, Koichi Akashi

Stem Cell Reports   7 ( 3 )   425 - 438   2016.9

A TIM-3/galectin-9 autocrine stimulatory loop drives self-renewal of human myeloid leukemia stem cells and leukemia progression Reviewed

Yoshikane Kikushige

57 ( 4 )   412 - 416   2016.4

Molecular targeted therapy for leukemic stem cells Reviewed

Yoshikane Kikushige

Nihon rinsho. Japanese journal of clinical medicine   73 ( 5 )   811 - 815   2015.5

CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis Redefinition of murine common myeloid progenitor Reviewed

Kohta Miyawaki, Yojiro Arinobu, Hiromi Iwasaki, Kentaro Kohno, Hirofumi Tsuzuki, Tadafumi Iino, Takahiro Shima, Yoshikane Kikushige, Katsuto Takenaka, Toshihiro Miyamoto, Koichi Akashi

STEM CELLS   33 ( 3 )   976 - 987   2015.3

Pre-malignant lymphoid cells arise from hematopoietic stem/progenitor cells in chronic lymphocytic leukemia Reviewed

Yoshikane Kikushige, Toshihiro Miyamoto

International journal of hematology   102 ( 5 )   528 - 535   2015.2

Identification of TIM-3 as a Leukemic Stem Cell Surface Molecule in Primary Acute Myeloid Leukemia Reviewed

Yoshikane Kikushige, Toshihiro Miyamoto

Oncology   89   28 - 32   2015.1

The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell Reviewed

Takahiro Shima, Toshihiro Miyamoto, Yoshikane Kikushige, Junichiro Yuda, Taro Tochigi, Goichi Yoshimoto, Koji Kato, Katsuto Takenaka, Hiromi Iwasaki, Shinichi Mizuno, Noriko Goto, Koichi Akashi

Experimental Hematology   42 ( 11 )   955 - 965.e5   2014.11

Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis Reviewed

Yoshikane Kikushige, Toshihiro Miyamoto

International journal of hematology   100 ( 4 )   335 - 340   2014.10

Acquired initiating mutations in early hematopoietic cells of CLL patients Reviewed

Cancer Discovery   4 ( 9 )   1088 - 1101   2014.9

Successful treatment of invasive zygomycosis based on a prompt diagnosis using molecular methods in a patient with acute myelogenous leukemia Reviewed

Junichiro Yuda, Koji Kato, Yoshikane Kikushige, Kiyofumi Ohkusu, Makiko Kiyosuke, Keiji Sakamoto, Seido Oku, Noriko Miyake, Masako Kadowaki, Tadafumi Iino, Kazuki Tanimoto, Katsuto Takenaka, Hiromi Iwasaki, Toshihiro Miyamoto, Nobuyuki Shimono, Takanori Teshima, Koichi Akashi

Internal Medicine   53 ( 10 )   1087 - 1091   2014

TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cells Reviewed

Yoshikane Kikushige, Toshihiro Miyamoto

International journal of hematology   98 ( 6 )   627 - 633   2013.12

Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b Reviewed

Tomohito Matsuo, Yukiko Noguchi, Mieko Shindo, Yoshifumi Morita, Yoshie Oda, Eiko Yoshida, Hiroko Hamada, Mine Harada, Yuichi Shiokawa, Takahiro Nishida, Ryuji Tominaga, Yoshikane Kikushige, Koichi Akashi, Jun Kudoh, Nobuyoshi Shimizu, Yuka Tanaka, Tsukuru Umemura, Taketoshi Taniguchi, Akihiko Yoshimura, Takashi Kobayashi, Masao Mitsuyama, Hironori Kurisaki, Hitoshi Katsuta, Seiho Nagafuchi

Gene   530 ( 1 )   19 - 25   2013.11

Reduced-intensity conditioning followed by cord blood transplantation in a patient with refractory folliculotropic mycosis fungoides Reviewed

Takashi Nakaike, Koji Kato, Seido Oku, Masayasu Hayashi, Yoshikane Kikushige, Mika Kuroiwa, Katsuto Takenaka, Hiromi Iwasaki, Toshihiro Miyamoto, Takanori Teshima, Koichi Ohshima, Koichi Akashi

International journal of hematology   98 ( 4 )   491 - 495   2013.10

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment Reviewed

Takuji Yamauchi, Katsuto Takenaka, Shingo Urata, Takahiro Shima, Yoshikane Kikushige, Takahito Tokuyama, Chika Iwamoto, Mariko Nishihara, Hiromi Iwasaki, Toshihiro Miyamoto, Nakayuki Honma, Miki Nakao, Takashi Matozaki, Koichi Akashi

Blood   121 ( 8 )   1316 - 1325   2013.2

Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation Reviewed

Takahiro Shima, Toshihiro Miyamoto, Yoshikane Kikushige, Yasuo Mori, Kenjiro Kamezaki, Ken Takase, Hideho Henzan, Akihiko Numata, Yoshikiyo Ito, Katsuto Takenaka, Hiromi Iwasaki, Tomohiko Kamimura, Tetsuya Eto, Koji Nagafuji, Takanori Teshima, Koji Kato, Koichi Akashi

Blood   121 ( 5 )   840 - 848   2013.1

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis Reviewed

Takuro Kuriyama, Katsuto Takenaka, Kentaro Kohno, Takuji Yamauchi, Shinya Daitoku, Goichi Yoshimoto, Yoshikane Kikushige, Junji Kishimoto, Yasunobu Abe, Naoki Harada, Toshihiro Miyamoto, Hiromi Iwasaki, Takanori Teshima, Koichi Akashi

Blood   120 ( 19 )   4058 - 4067   2012.11

Low incidence of adenovirus hemorrhagic cystitis following autologous hematopoietic stem cell transplantation in the rituximab era Reviewed

Yasuo Mori, Toshihiro Miyamoto, Kenjiro Kamezaki, Koji Kato, Yoshikane Kikushige, Shuichiro Takashima, Shingo Urata, Shinji Shimoda, Nobuyuki Shimono, Katsuto Takenaka, Hiromi Iwasaki, Koji Nagafuji, Takanori Teshima, Koichi Akashi

American Journal of Hematology   87 ( 8 )   828 - 830   2012.8

Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis Reviewed

Chiyo Mizuochi, Stuart T. Fraser, Katia Biasch, Yuka Horio, Yoshikane Kikushige, Kenzaburo Tani, Koichi Akashi, Manuela Tavian, Daisuke Sugiyama

PloS one   7 ( 4 )   2012.4

CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells Reviewed

Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Yoshikane Kikushige, Takahiro Shima, Kumiko Noda, Shun Ichiro Ota, Hirofumi Tsuzuki, Yasushi Inoue, Yojiro Arinobu, Hiromi Iwasaki, Shinji Shimoda, Eishi Baba, Hiroshi Tsukamoto, Takahiko Horiuchi, Tadayoshi Taniyama, Koichi Akashi

Blood   119 ( 10 )   2263 - 2273   2012.3

TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia Reviewed

Yoshikane Kikushige, Koichi Akashi

Annals of the New York Academy of Sciences   1266 ( 1 )   118 - 123   2012.1

[Specific surface markers of AML-leukemic stem cells]. Reviewed

Yoshikane Kikushige, Toshihiro Miyamoto, Koichi Akashi

52 ( 7 )   531 - 534   2011.7

JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation Research paper Reviewed

Seido Oku, Katsuto Takenaka, Takuro Kuriyama, Kotaro Shide, Takashi Kumano, Yoshikane Kikushige, Shingo Urata, Takuji Yamauchi, Chika Iwamoto, Haruko K. Shimoda, Toshihiro Miyamoto, Koji Nagafuji, Junji Kishimoto, Kazuya Shimoda, Koichi Akashi

British Journal of Haematology   150 ( 3 )   334 - 344   2010.8

[Hematopoietic stem cells are primarily involved in pathogenesis of chronic lymphocytic leukemia]. Reviewed

Yoshikane Kikushige, Toshihiro Miyamoto, Koichi Akashi

[Rinsho ketsueki] The Japanese journal of clinical hematology   51 ( 8 )   679 - 684   2010.8

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation Reviewed

Goichi Yoshimoto, Toshihiro Miyamoto, Siamak Jabbarzadeh-Tabrizi, Tadafumi Iino, Jennifer L. Rocnik, Yoshikane Kikushige, Yasuo Mori, Takahiro Shima, Hiromi Iwasaki, Katsuto Takenaka, Koji Nagafuji, Shin Ichi Mizuno, Hiroaki Niiro, Gary D. Gilliland, Koichi Akashi

Blood   114 ( 24 )   5034 - 5043   2009.12

T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM⁺ memory B cells through altering balances in Bcl-2 family proteins Reviewed

Siamak Jabbarzadeh Tabrizi, Hiroaki Niiro, Mariko Masui, Goichi Yoshimoto, Tadafumi Iino, Yoshikane Kikushige, Takahiro Wakasaki, Eishi Baba, Shinji Shimoda, Toshihiro Miyamoto, Toshiro Hara, Koichi Akashi

Journal of Immunology   182 ( 3 )   1490 - 1499   2009.2

Identification of the human eosinophil lineage-committed progenitor Revision of phenotypic definition of the human common myeloid progenitor Reviewed

Yasuo Mori, Hiromi Iwasaki, Kentaro Kohno, Goichi Yoshimoto, Yoshikane Kikushige, Aki Okeda, Naokuni Uike, Hiroaki Niiro, Katsuto Takenaka, Koji Nagafuji, Toshihiro Miyamoto, Mine Harada, Kiyoshi Takatsu, Koichi Akashi

Journal of Experimental Medicine   206 ( 1 )   183 - 193   2009.1

Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival Reviewed International journal

Yoshikane Kikushige, Goichi Yoshimoto, Toshihiro Miyamoto, Tadafumi Iino, Yasuo Mori, Hiromi Iwasaki, Hiroaki Niiro, Katsuto Takenaka, Koji Nagafuji, Mine Harada, Fumihiko Ishikawa, Koichi Akashi

The Journal of Immunology   ( 180 )   2008.3

Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival Reviewed

Yoshikane Kikushige, Goichi Yoshimoto, Toshihiro Miyamoto, Tadafumi Iino, Yasuo Mori, Hiromi Iwasaki, Hiroaki Niiro, Katsuto Takenaka, Koji Nagafuji, Mine Harada, Fumihiko Ishikawa, Koichi Akashi

Journal of Immunology   180 ( 11 )   7358 - 7367   2008.1

Toxoplasmosis encephalitis following severe graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation 17 Yr experience in Fukuoka BMT group Reviewed

Yayoi Matsuo, Shoichiro Takeishi, Toshihiro Miyamoto, Atsushi Nonami, Yoshikane Kikushige, Yuya Kunisaki, Kenjiro Kamezaki, Liping Tu, Hajime Hisaeda, Katsuto Takenaka, Naoki Harada, Tomohiko Kamimura, Yuju Ohno, Tetsuya Eto, Takanori Teshima, Hisashi Gondo, Mine Harada, Koji Nagafuji

European Journal of Haematology   79 ( 4 )   317 - 321   2007.10

Repeated relapses of acute myelogenous leukemia in the isolated extramedullary sites following allogeneic bone marrow transplantations Reviewed International journal

Yoshikane Kikushige, Ken Takase, Keiko Sata, Ken-ichi Aoki, Akihiko Numata, Toshihiro Miyamoto, Takahiro Fukuda, Hisashi Gondo, Mine Harada, Koji Nagafuji

Intern Med   ( 46 )   2007.8

Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma Reviewed International journal

Kenjiro Kamezaki, Yoshikane Kikushige, Akihiko Numata, Toshihiro Miyamoto, Ken Takase, Hideho Henzan, Ken-ichi Aoki, Koji Kato, Atsushi Nonami, Tomohiko Kamimura, Fumihiko Arima, Katsuto Takenaka, Naoki Harada, Takahiro Fukuda, Shin Hayashi, Yujyu Ohno, Tetsuya Eto, Mine Harada, Koji Nagafuji

Bone Marrow Transplant   ( 39 )   2007.8

Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis Reviewed

Koji Nagafuji, Atsushi Nonami, Takashi Kumano, Yoshikane Kikushige, Goichi Yoshimoto, Katsuto Takenaka, Kazuya Shimoda, Shouichi Ohga, Masaki Yasukawa, Hisanori Horiuchi, Eiichi Ishii, Mine Harada

Haematologica   92 ( 7 )   978 - 981   2007.7

Repeated relapses of acute myelogenous leukemia in the isolated extramedullary sites following allogeneic bone marrow transplantations Reviewed

Yoshikane Kikushige, Ken Takase, Keiko Sata, Ken Ichi Aoki, Akihiko Numata, Toshihiro Miyamoto, Takahiro Fukuda, Hisashi Gondo, Mine Harada, Koji Nagafuji

Internal Medicine   46 ( 13 )   1011 - 1014   2007.7

Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma Reviewed

K. Kamezaki, Y. Kikushige, A. Numata, T. Miyamoto, K. Takase, H. Henzan, K. Aoki, K. Kato, A. Nonami, T. Kamimura, F. Arima, K. Takenaka, N. Harada, T. Fukuda, S. Hayashi, Y. Ohno, T. Eto, M. Harada, K. Nagafuji

Bone Marrow Transplantation   39 ( 9 )   523 - 527   2007.5

Late relapse of acute myelogenous leukemia followed by epstein-barr virus-associated lymphoproliferative disease 11 years after allogeneic bone marrow transplantation Reviewed International journal

Yoshikane Kikushige, Ken Takase, Toshihiro Miyamoto, Akihiko Numata, Kenjiro Kamezaki, Takahiro Fukuda, Koji Nagafuji, Hisashi Gondo, Mine Harada

International Journal of Hematology   ( 84 )   2006.12

Identification of the enhanced lipid metabolism pathway in leukemic stem cells Invited

2021.9 

Establishment of patient derived xenograft models of idiopathic multicentric Castleman disease Invited International conference

1st International Symposium on Castleman Disease  2021.9 

Identification of BCAAs metabolism pathway as a critical metabolic machinery for the maintenance of human acute leukemia-initiating cells Invited

Yoshikane Kikushige and Koichi Akashi

2020.10 

若手・融合がもたらすがん研究ブレークスルー Invited

菊繁吉謙

第79回日本癌学会学術総会特別企画  2020.10 

Stem Cells in Acute Myeloid Leukemia Invited International conference

Yoshikane Kikushige and Koichi Akashi

11th Eurasian Hematology-Oncology Congress, EHOG-JSH joint symposium  2020.10 

Identification of BCAAs metabolism pathway as a critical metabolic machinery for the maintenance of human acute leukemia-initiating cells Invited

Yoshikane Kikushige

2020.10 

ヒト急性白血病に共通する幹細胞性維持機構としてのアミノ酸代謝経路の解明 Invited

菊繁吉謙　赤司浩一

第93回日本生化学学会  2020.9 

Evaluation of residual TIM-3+ LSC is a promising approach to predict the clinical outcome of allo-SCT Invited International conference

Yoshikane Kikushige and Koichi Akashi

25th Congress of European Hematology Association, EHA-JSH joint symposium  2020.6 

Acute Myeloid Leukemia Stem Cell-targeted Therapies Invited

2010.9 

Hematopoietic stem cells are primarily involved in pathogenesis of chronic lymphocytic leukemia

2009.10 

Hematopoietic Stem Cells Are Primarily Involved in Pathogenesis of Chronic Lymphocytic Leukemia International conference

Yoshikane Kikushige, Toshihiro Miyamoto, Tadafumi Iino, Fumihiko Ishikawa, Koichi Akashi

50th American Society of Hematology annual meeting  2008.12 

ヒト正常造血におけるFlt3の発現および機能解析

菊繁吉謙　吉本五一　石川文彦　宮本敏浩　赤司浩一

日本血液学会総会  2007.10 

Human FLT3/FLK2 targets hematopoietic stem cells and granulocyte/macrophage progenitors International conference

Yoshikane Kikushige, Goichi Yoshimoto, Toshihiro Miyamoto, Fumihiko Ishikawa, Hiromi Iwasaki, Koichi Akashi

49th American Society of Hematology annual meeting,  2007.12 

日本内科学会

白血病幹細胞特異的窒素代謝機構の解明と治療応用

2023 - 2024

ノバルティス科学振興財団研究奨励金

白血病幹細胞特異的ミトコンドリア活性化機構の解明および新規治療モデルの確立

Grant number：22H03105  2022 - 2025

日本学術振興会  科学研究費助成事業  基盤研究(B)

TIM-3シグナルが制御する白血病幹細胞特異的ミトコンドリア代謝制御メカニズムの解明と治療応用

2022

日本血液学会研究助成

スフィンゴシン１リン酸シグナル経路を標的としたヒト白血病幹細胞の治療抵抗性克服戦略の構築

2022

日本先進医療財団研究助成

フォスファチジン酸合成経路を標的としたヒト白血病幹細胞根絶のための新規治療

2021

武田科学振興財団　研究助成

IMiDsにおける新規基質同定による新規がん治療戦略の構築

Grant number：20K21617  2020 - 2021

日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

ヒト白血病幹細胞特異的代謝特性を標的とした治療法の確立

2020 - 2021

化血研若手研究奨励助成

ヒト白血病幹細胞特異的代謝特性としてのフォスファチジン酸代謝経路の解明と標的治療法の確立

2020 - 2021

新日本先進医療研究財団助成金

ヒト急性白血病に共通する悪性幹細胞特異的な代謝経路の同定

Grant number：19H03687  2019 - 2021

日本学術振興会  科学研究費助成事業  基盤研究(B)

アミノ酸代謝経路によるがん幹細胞制御機構の解明と治療応用

2019

高松宮妃癌研究基金

Exhaustion関連分子による白血病幹細胞制御機構の解明

Grant number：16H06250  2016 - 2018

科学研究費助成事業  若手研究(A)