Updated on 2024/10/02

Information

 

写真a

 
SAKAMOTO KAZUO
 
Organization
Kyushu University Hospital Coronary Care Unit Lecturer
School of Medicine Department of Medicine（Joint Appointment）
Title
Lecturer
Contact information
メールアドレス
Tel
0926425360
Profile
カテーテルアブレーションおよびペースメーカー、植え込み型除細動器（ICD）等のデバイス治療を含む不整脈診療全般を担当している。基礎心疾患（心不全・弁膜症）を合併した重症不整脈患者が増加しており、成人先天性心疾患患者における複雑かつ難治性の不整脈治療にも挑んでいる。学会活動や論文発表も積極的に行っている。
External link

Degree

  • M.D., Ph.D.

Research Interests・Research Keywords

  • Research theme：Basic and clinical research on arrhythmia and electrophysiology.

    Keyword：Arrhythmia, Catheter ablation

    Research period： 2019.4 - 2020.3

Papers

  • Impact of the Coronavirus Disease 2019(COVID-19) Pandemic on the Severity and the Mortality of Acute Myocardial Infarction in Japan: Analysis From the JROAD-DPC Database(タイトル和訳中)

    Kimura Mitsukuni, Matoba Tetsuya, Nakano Yasuhiro, Katsuki Shunsuke, Sakamoto Kazuo, Nishihara Masaaki, Nagata Takuya, Tahara Yoshio, Nagao Ken, Okura Hiroyuki, Ikeda Takanori, Nakai Michikazu, Tsutsui Hiroyuki

    Circulation Reports   6 ( 6 )   191 - 200   2024.6

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    Language：English   Publisher：(一社)日本循環器学会  

  • Paced QRS morphology mimicking complete left bundle branch block induced by right ventricular pacing is associated with pacing-induced cardiomyopathy. Invited Reviewed International journal

    Ikeda S, Sakamoto K, Sugawara M, Yakabe D, Nagaoka K, Kowase S, Inoue S, Morishige K, Mukai Y, Tsutsui H, Kinugawa S.

    J Cardiovasc Electrophysiol. 2024;35:906-915.   2024.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Paced QRS morphology mimicking complete left bundle branch block induced by right ventricular pacing is associated with pacing-induced cardiomyopathy

    Ikeda, S; Sakamoto, K; Sugawara, M; Yakabe, D; Nagaoka, K; Kowase, S; Inoue, S; Morishige, K; Mukai, Y; Tsutsui, H; Kinugawa, S

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   35 ( 5 )   906 - 915   2024.5   （ ISSN:1045-3873 eISSN:1540-8167 ）

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    Language：English   Publisher：Journal of Cardiovascular Electrophysiology  

    Introduction: Right ventricular (RV) pacing sometimes causes left ventricular (LV) systolic dysfunction, also known as pacing-induced cardiomyopathy (PICM). However, the association between specifically paced QRS morphology and PICM development has not been elucidated. This study aimed to investigate the association between paced QRS mimicking a complete left bundle branch block (CLBBB) and PICM development. Methods: We retrospectively screened 2009 patients who underwent pacemaker implantation from 2010 to 2020 in seven institutions. Patients who received pacemakers for an advanced atrioventricular block or bradycardia with atrial fibrillation, baseline LV ejection fraction (LVEF) ≥ 50%, and echocardiogram recorded at least 6 months postimplantation were included. The paced QRS recorded immediately after implantation was analyzed. A CLBBB-like paced QRS was defined as meeting the CLBBB criteria of the American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society in 2009. PICM was defined as a ≥10% LVEF decrease, resulting in an LVEF of <50%. Results: Among the 270 patients analyzed, PICM was observed in 38. Baseline LVEF was lower in patients with PICM, and CLBBB-like paced QRS was frequently observed in PICM. Multivariate analysis revealed that low baseline LVEF (odds ratio [OR]: 0.93 per 1% increase, 95% confidence interval [CI]: 0.89–0.98, p = 0.006) and CLBBB-like paced QRS (OR: 2.69, 95% CI: 1.25–5.76, p = 0.011) were significantly associated with PICM development. Conclusion: CLBBB-like paced QRS may be a novel risk factor for PICM. RV pacing, which causes CLBBB-like QRS morphology, may need to be avoided, and patients with CLBBB-like paced QRS should be followed-up carefully.

    DOI： 10.1111/jce.16229

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  • Overview of the 87th Annual Scientific Meeting of the Japanese Circulation Society (JCS2023)　- New Challenge With Next Generation. Invited Reviewed International journal

    2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Mapping of Purkinje-related ventricular arrhythmias by a multispline catheter with small and close-paired electrodes: Comparison with conventional catheters. Invited Reviewed International journal

    Takase S, Mukai Y, Nagaoka K, Ogawa K, Kawai S, Honda N, Nagayama T, Tohyama T, Inoue S, Sadamatsu K, Tashiro H, Sakamoto K, Matoba T, Chishaki A, Kinugawa S, Tsutsui H.

    Pacing Clin Electrophysiol. 2024;47:5-18.   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Mapping of Purkinje-related ventricular arrhythmias by a multispline catheter with small and close-paired electrodes: Comparison with conventional catheters

    Takase, S; Mukai, Y; Nagaoka, K; Ogawa, K; Kawai, S; Honda, N; Nagayama, T; Tohyama, T; Inoue, S; Sadamatsu, K; Tashiro, H; Sakamoto, K; Matoba, T; Chishaki, A; Kinugawa, S; Tsutsui, H

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   47 ( 1 )   5 - 18   2024.1   （ ISSN:0147-8389 eISSN:1540-8159 ）

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    Language：English   Publisher：PACE - Pacing and Clinical Electrophysiology  

    Background: Precise mapping of the Purkinje fiber network is essential in catheter ablation of Purkinje-related ventricular arrhythmias (PrVAs). We sought to evaluate the mapping ability of a multi-spline duodecapolar catheter (PentaRay) for PrVAs. Methods: Mappings of Purkinje fibers by PentaRay catheters were compared with those by conventional mapping catheters in consecutive patients undergoing catheter ablation of PrVAs from 2015 to 2022. Results: Sixteen PrVAs (7 premature ventricular contractions or non-reentrant fascicular tachycardias [PVCs/NRFTs] and 9 fascicular ventricular tachycardias [FVTs]) were retrospectively studied. In PVCs/NRFTs, earliest preceding Purkinje potentials (PPs) could be recorded by the PentaRay catheters but not by the mapping and ablation catheters in 5 cases. At the earliest PP sites, the precedence from the QRS onset was greater, and the amplitude of the preceding potentials was higher in the PentaRay catheter compared with those in the mapping and ablation catheter (−62.0 ± 42.8 vs. −29.4 ± 34.2 ms, P = 0.02; 0.45 ± 0.43 vs. 0.09 ± 0.08 mV, P = 0.02). In FVTs, late diastolic potentials (P1) were recorded by the PentaRay catheters but not by the mapping and ablation catheters or the linear duodecapolar catheter in 2 cases. The amplitude of P1 was higher in the PentaRay catheter compared with that in the linear duodecapolar catheter and the mapping and ablation catheters (0.72 ± 0.49 vs. 0.17 ± 0.18 vs. 0.27 ± 0.21 mV, P = 0.0006, P = 0.002). The localized critical PPs, defined as the earliest preceding potentials in PVCs/NRFTs and P1 in FVTs, could be recorded in all the patients by the PentaRay catheter. The mapping ability of critical PPs of PrVAs was better with the PentaRay catheter than with the conventional mapping catheters (16/16 vs. 9/16, P = 0.004 by McNemar exact test). Conclusions: The PentaRay catheter has clinical advantages in mapping of the Purkinje fiber network to reveal critical PPs as ablation targets of PrVAs.

    DOI： 10.1111/pace.14906

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  • Successful mapping and ablation of a pediatric-onset non-reentrant fascicular tachycardia Invited Reviewed International journal

    Nagatomo Y, Takase S, Sakamoto K, Nagata H, Yamamura K, Tsutsui H, Ohga S.

    J Cardiol Cases. 2023;29:165-169.   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Biventricular activation of right bundle branch block pattern ventricular tachycardia originating from the right ventricle in Ebstein's anomaly. Invited Reviewed International journal

    Sakamoto K, Takase S, Ikeda Y, Sakamoto I.

    Heart Rhythm Case Rep. 2023;10:109-111.   2023.10

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Efficacy of Early Catheter Ablation for Atrial Fibrillation After Admission for Heart Failure. Invited Reviewed International journal

    Sakamoto K, Tohyama T, Ide T, Mukai Y, Enzan N, Nagata T, Ikeda M, Takase S, Nagayama T, Fujino T, Matsushima S, Tsutsui H.

    JACC Clin Electrophysiol. 2023;9:1948-1959.   2023.9

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  • Efficacy of Early Catheter Ablation for Atrial Fibrillation After Admission for Heart Failure

    Sakamoto, K; Tohyama, T; Ide, T; Mukai, Y; Enzan, N; Nagata, T; Ikeda, M; Takase, S; Nagayama, T; Fujino, T; Matsushima, S; Tsutsui, H

    JACC-CLINICAL ELECTROPHYSIOLOGY   9 ( 9 )   1948 - 1959   2023.9   （ ISSN:2405-500X eISSN:2405-5018 ）

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    Language：English   Publisher：JACC: Clinical Electrophysiology  

    Background: Advances in catheter ablation (CA) for atrial fibrillation (AF) have improved the prognosis of patients with heart failure (HF) and AF. However, its optimal timing remains to be fully elucidated. Objectives: The aim of this study was to investigate the prognostic impact of early CA in patients with HF and AF hospitalized for worsening HF. Methods: From JROADHF (Japanese Registry of Acute Decompensated Heart Failure) (n = 13,238), patients with HF and AF who underwent CA within 90 days after admission for HF (early CA; n = 103) and those who did not (control; n = 2,683) were identified. Mortality was compared between these groups in the crude cohort, as well as in the propensity-matched cohort (n = 83 in each group). Results: In the crude cohort, all-cause mortality was significantly lower in the early CA group than in the control group (log-rank P < 0.001; HR: 0.38; 95% CI: 0.24-0.60). In the matched cohort, all-cause mortality was likewise significantly lower in the early CA group (log-rank P = 0.014; HR: 0.47; 95% CI: 0.25-0.88). Cardiovascular death and HF mortality were significantly lower in both cohorts (crude: Gray’ test: P < 0.001 and P = 0.005; subdistribution HR: 0.28 [95% CI: 0.13-0.63] and HR: 0.31 [95% CI: 0.13-0.75]; matched: Gray's test: P = 0.006 and P = 0.017; subdistribution HR: 0.24 [95% CI: 0.08-0.70] and HR: 0.28 [95% CI: 0.09-0.84], respectively). Conclusions: In a nationwide representative real-world cohort, CA for AF within 90 days after admission for HF was associated with improved long-term outcomes, including cardiovascular and HF death in patients with HF and AF.

    DOI： 10.1016/j.jacep.2023.05.038

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  • Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC. Invited Reviewed International journal

    Sakamoto K, Matoba T, Nakai M, Tahara Y, Nakashima T, Hosoda H, Miyamoto Y, Nishimura K, Sumita Y, Yagi T, Ichimura K, Yonemoto N, Tachibana E, Nagao K, Ikeda T, Sato N, Tsutsui H.

    Heart Vessels. 2023 Feb;38(2):228-235.   2023.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Deep Learning of ECG for the Prediction of Postoperative Atrial Fibrillation. Invited Reviewed International journal

    Tohyama T, Ide T, Ikeda M, Nagata T, Tagawa K, Hirose M, Funakoshi K, Sakamoto K, Kishimoto J, Todaka K, Nakashima N, Tsutsui H.

    Circ Arrhythm Electrophysiol. 2023 Feb;16(2):e011579.   2023.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • 静脈脱血-動脈送血型膜型人工肺の装着期間の臨床像　JROAD-DPCの解析(Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC)

    Sakamoto Kazuo, Matoba Tetsuya, Nakai Michikazu, Tahara Yoshio, Nakashima Takahiro, Hosoda Hayato, Miyamoto Yoshihiro, Nishimura Kunihiro, Sumita Yoko, Yagi Tsukasa, Ichimura Kenzo, Yonemoto Naohiro, Tachibana Eizo, Nagao Ken, Ikeda Takanori, Sato Naoki, Tsutsui Hiroyuki

    Heart and Vessels   38 ( 2 )   228 - 235   2023.2   （ ISSN:0910-8327 ）

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    Language：English   Publisher：シュプリンガー・ジャパン(株)  

    循環器疾患診療実態調査に基づくJROAD-DPCデータを用いて、静脈脱血-動脈送血による膜型人工肺(VA-ECMO)の装着期間が予後に及ぼす影響について検討した。対象は入院当日にVA-ECMOを導入した20歳以上の心血管疾患患者5766例で、急性呼吸窮迫症候群または補助人工心臓の植込み前にECMOを導入した症例は除外した。疾患別では冠動脈疾患が2561例(44.4%)で最も多く、次いで肺血栓塞栓症が333例(5.1%)、心筋炎が293例(5.1%)であった。患者を院内転帰に応じて死亡群3629例(男性76.1%、平均62.8±14.3歳)と生存群2137例(男性72.2%、平均59.4±15.2歳)の2群に分類した。VA-ECMOの使用期間は死亡群(平均2.12±2.20日)の方が生存群(平均1.90±1.82日)より有意に長かった(P<0.001)。多変量解析でECMO期間は生存率と有意に関連し、年齢および疾患別に交絡因子を調整した後も、ハザード比は1日のECMO装着(1.72)の方が2日(0.60)、3日(0.75)、4日(0.43)より有意に高かった(P<0.001)。

  • Deep Learning of ECG for the Prediction of Postoperative Atrial Fibrillation

    Tohyama, T; Ide, T; Ikeda, M; Nagata, T; Tagawa, K; Hirose, M; Funakoshi, K; Sakamoto, K; Kishimoto, J; Todaka, K; Nakashima, N; Tsutsui, H

    CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY   16 ( 2 )   110 - 112   2023.2   （ ISSN:1941-3149 eISSN:1941-3084 ）

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    Language：English   Publisher：Circulation: Arrhythmia and Electrophysiology  

    DOI： 10.1161/CIRCEP.122.011579

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  • Clinical picture of the duration of venoarterial extracorporeal membrane oxygenation: analysis from JROAD-DPC

    Sakamoto K., Matoba T., Nakai M., Tahara Y., Nakashima T., Hosoda H., Miyamoto Y., Nishimura K., Sumita Y., Yagi T., Ichimura K., Yonemoto N., Tachibana E., Nagao K., Ikeda T., Sato N., Tsutsui H.

    Heart and Vessels   38 ( 2 )   228 - 235   2023.2   （ ISSN:09108327 ）

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    Language：English   Publisher：Heart and Vessels  

    Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used for critically ill patients all over the world; however, comprehensive survey regarding the relationship between VA-ECMO duration and prognosis is limited. We conducted a survey of VA-ECMO patients in the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination (JROAD-DPC), which was a health insurance claim database study among cardiovascular centers associated with the Japan Circulation Society, between April 2012 and March 2016. Out of 13,542 VA-ECMO patients, we analyzed 5766 cardiovascular patients treated with VA-ECMO. 68% patients used VA-ECMO only for 1 day and 93% had VA-ECMO terminated within 1 week. In multivariate analysis, the hazard ratio of 1-day support was significantly high at 1.72 (95% confidence intervals; 95% CI 1.53–1.95) (p < 0.001), while that of 2-day [0.60 (95% CI 0.49–0.73)], 3-day [0.75 (95% CI 0.60–0.94)], 4-day [0.43 (95% CI 0.31–0.60)] and 5-day support [0.62 (95% CI 0.44–0.86)] was significantly low. Comprehensive database analysis of JROAD-DPC revealed that cardiovascular patients who were supported with VA-ECMO for 2–5 days showed lower mortality. The optimal VA-ECMO support window should be investigated in further studies.

    DOI： 10.1007/s00380-022-02158-0

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  • 近位心臓伝導系に起源を持つ反復性巣状プルキンエ心室不整脈の電気生理学的所見(Electrophysiological features of repetitive focal Purkinje ventricular arrhythmias originating from the proximal cardiac conduction system)

    Ikeda Shota, Sakamoto Kazuo, Tokudome Daigo, Kawai Shunsuke, Ogawa Kiyohiro, Nagaoka Kazuhiro, Takase Susumu, Kowase Shinya, Mukai Yasushi, Nogami Akihiko, Tsutsui Hiroyuki

    Journal of Arrhythmia   38 ( 6 )   1070 - 1079   2022.12   （ ISSN:1880-4276 ）

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    Language：English   Publisher：(一社)日本不整脈心電学会  

    伝導系の近位部から発する巣状プルキンエ心室不整脈(FPVA)に関連してみられる所見を明らかにした。2008～2020年に5病院でFPVAと診断され高周波カテーテルアブレーション(RFCA)が行われた患者18名(男性11名、年齢18～75歳)を後方視的に検討した。そのFPVAの起源が心臓伝導系の近位部にあると判定された近位群は7名存在した。臨床的に心室不整脈(VA)と考えられた時の心電図で複数のQRS形態が観察されたのは、近位群の7名中4名、非近位群の11名中では1名のみであった(p=0.047)。VA時のQRS幅は非近位群に比べ近位群で有意に短縮していた。洞調律時とVA時で電気軸角度にみられた差の絶対値は、近位群で80.4±46.1度、非近位群では138.8±59.6度となり(p=0.003)、この絶対差が134度以下という基準を定めると両群を識別するのに有用であった。VAの再発は両群で3名ずつに発生した。RFCA処置に関連した伝導ブロックの例は観察されなかった。以上のように、臨床的VAで多様なQRS形態が観察されること、およびVA時に変化した電気軸角度の絶対差が134度以下であることは、FPVAの起源が伝導系近位部にあることを指し示していた。RFCAを行うことで、重度の伝導障害を起こすことなく近位部起源のFPVAを抑制できると結論された。

  • Electrophysiological features of repetitive focal Purkinje ventricular arrhythmias originating from the proximal cardiac conduction system

    Ikeda, S; Sakamoto, K; Tokudome, D; Kawai, S; Ogawa, K; Nagaoka, K; Takase, S; Kowase, S; Mukai, Y; Nogami, A; Tsutsui, H

    JOURNAL OF ARRHYTHMIA   38 ( 6 )   1070 - 1079   2022.12   （ ISSN:1880-4276 eISSN:1883-2148 ）

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    Language：English   Publisher：Journal of Arrhythmia  

    Background: Focal Purkinje ventricular arrhythmias (VAs) might originate from the vicinity of the proximal portion of the cardiac conducting system. This study aimed to clarify the features associated with focal Purkinje VAs originating from the proximal conduction system. Methods: A total of 18 patients with focal Purkinje VAs undergoing radiofrequency catheter ablation (RFCA) were retrospectively examined and divided into the proximal type or the non-proximal type. The proximal type was defined as having the origin at the proximal half of the interventricular septum, or the proximal half and the septal side of the anterior wall. The 12-lead electrocardiogram and electrophysiological findings were investigated. Results: Seven patients met criteria for proximal type of focal Purkinje VA. Out of the 7, 4 patients with proximal VAs had multiple QRS morphologies of VAs clinically, whereas out of 11 patients with non-proximal VAs, only 1 had multiple morphologies (p =.047). VA QRS duration was shorter in the proximal type than in the non-proximal type (111.2 ± 19.8 ms vs. 135.7 ± 17.7 ms; p =.003). The absolute axis difference between sinus rhythm and VA was smaller in the proximal type (80.4 ± 46.1°vs. 138.8 ± 59.6°; p =.014). The absolute axis difference ≤134° was useful in distinguishing the two types. Recurrence of VA was recorded in 3 proximal type patients and 3 non-proximal type patients. No procedure-related conduction block was observed. Conclusion: A VA of absolute axis difference ≤134°, and multiple QRS morphologies of clinical VAs indicate a proximal origin. Focal Purkinje VAs from proximal origins can be suppressed by RFCA without severe conduction disturbance.

    DOI： 10.1002/joa3.12787

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  • Electrophysiological features of repetitive focal Purkinje ventricular arrhythmias originating from the proximal cardiac conduction system. Invited Reviewed International journal

    Ikeda S, Sakamoto K, Tokudome D, Kawai S, Ogawa K, Nagaoka K, Takase S, Kowase S, Mukai Y, Nogami A, Tsutsui H.

    J Arrhythm. 2022 Oct 7;38(6):1070-1079. doi: 10.1002/joa3.12787. eCollection 2022 Dec.   2022.10

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Artificial Intelligence in Electrocardiology for Arrhythmia Diagnosis

    Mukai Yasushi, Tohyama Takeshi, Sakamoto Kazuo

    Circulation Journal   86 ( 8 )   1281 - 1282   2022.7   （ ISSN:13469843 eISSN:13474820 ）

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    Language：English   Publisher：The Japanese Circulation Society  

    DOI： 10.1253/circj.cj-22-0229

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  • Artificial Intelligence in Electrocardiology for Arrhythmia Diagnosis Invited Reviewed International journal

    Mukai Y, Tohyama T, Sakamoto K.

    Circ J. 2022 May 18. doi: 10.1253/circj.CJ-22-0229.   2022.5

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  • Location and coupling interval of an ectopic excitation determine the initiation of atrial fibrillation from the pulmonary veins Invited Reviewed International journal

    Kawai S, Mukai Y, Inoue S, Yakabe D, Nagaoka K, Sakamoto K, Takase S, Chishaki A, Tsutsui H.

    J Cardiovasc Electrophysiol. 2022 Apr;33(4):629-637.   2022.4

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  • Intra-atrial activation pattern is useful to localize the areas of non-pulmonary vein triggers of atrial fibrillation Invited Reviewed International journal

    Sakamoto K, Mukai Y, Kawai S, Nagaoka K, Inoue S, Takase S, Yakabe D, Ikeda S, Mannoji H, Nagayama T, Chishaki A, Tsutsui H.

    PLoS One. 2022 Apr 25;17(4):e0264894.   2022.4

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  • Mexiletine effectively prevented refractory Torsades de Pointes and ventricular fibrillation in a patient with congenital type 2 long QT syndrome Invited Reviewed International journal

    Nakashima R, Takase S, Kai K, Sakamoto K, Tsutsui H.

    J Cardiovasc Electrophysiol. 2022 Apr 30. doi: 10.1111/jce.15517.   2022.4

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  • Location and coupling interval of an ectopic excitation determine the initiation of atrial fibrillation from the pulmonary veins

    Kawai, S; Mukai, Y; Inoue, S; Yakabe, D; Nagaoka, K; Sakamoto, K; Takase, S; Chishaki, A; Tsutsui, H

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   33 ( 4 )   629 - 637   2022.4   （ ISSN:1045-3873 eISSN:1540-8167 ）

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    Language：English   Publisher：Journal of Cardiovascular Electrophysiology  

    Introduction: Ectopic beats originating from the pulmonary vein (PV) trigger atrial fibrillation (AF). The purpose of this study was to clarify the electrophysiological determinant of AF initiation from the PVs. Methods: Pacing studies were performed with a single extra stimulus mimicking an ectopic beat in the left superior PVs (LSPVs) in 62 patients undergoing AF ablation. Inducibility of AF, effective refractory period (ERP), and conduction properties within the PVs were analyzed. Results: A single extra stimulus in LSPV induced AF in 20 patients (32% of all patients) at the mean coupling interval (CI) of 172 ms. A CI-dependent anisotropic conduction at the AF onset was visualized in a three-dimensional mapping. Onset of AF was site-specific with reproducibility in each individual. Mean ERP in LSPV in the AF-inducible group was shorter than that in the AF-noninducible group (182 ± 55 vs. 254 ± 51 ms, p <.0001). LSPV ERP dispersion was greater in the AF-inducible group than in the AF-noninducible group (45 ± 28 vs. 27 ± 19 ms, p <.01). Circumferential intra-PV conduction time (IPVCT) exhibited decremental properties in response to shortening of CI and the prolongation of IPVCT in the AF-inducible site was greater than that in the AF-noninducible site (p <.05) in each individual. Conclusions: Location and CI of an ectopic excitation ultimately determine the initiation of AF from the PVs. ERP dispersion and circumferential conduction delay may lead to anisotropic conduction and reentry within the PVs that initiate AF.

    DOI： 10.1111/jce.15371

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  • Institutional Characteristics and Prognosis of Acute Myocardial Infarction With Cardiogenic Shock in Japan - Analysis From the JROAD/JROAD-DPC Database Reviewed International journal

    Matoba T, Sakamoto K, Nakai M, Ichimura K, Mohri M, Tsujita Y, Yamasaki M, Ueki Y, Tanaka N, Hokama Y, Fukutomi M, Hashiba K, Fukuhara R, Suwa S, Matsuura H, Hosoda H, Nakashima T, Tahara Y, Sumita Y, Nishimura K, Miyamoto Y, Yonemoto N, Yagi T, Tachibana E, Nagao K, Ikeda T, Sato N, Tsutsui H.

    Circ J. 2021 Sep 24;85(10):1797-1805.   2021.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Treatment With Vasopressor Agents for Cardiovascular Shock Patients With Poor Renal Function; Results From the Japanese Circulation Society Cardiovascular Shock Registry Invited Reviewed International journal

    Yagi T, Nagao K, Tachibana E, Yonemoto N, Sakamoto K, Ueki Y, Imamura H, Miyamoto T, Takahashi H, Hanada H, Chiba N, Tani S, Matsumoto N, Okumura Y.

    Front Med (Lausanne). 2021 May 3;8:648824.   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Effusive-constrictive pericarditis secondary to pneumopericardium associated with gastropericardial fistula. Invited Reviewed International journal

    Ono Y, Hashimoto T, Sakamoto K, Matsushima S, Higo T, Sonoda H, Kimura Y, Mori M, Shiose A, Tsutsui H.

    ESC Heart Fail. 2021 Feb;8(1):778-781.   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Bigeminal potentials in the pulmonary vein indicate arrhythmogenic trigger of atrial fibrillation Invited Reviewed International journal

    Mukai Y, Kawai S, Inoue S, Takase S, Sakamoto K, Nagaoka K, Chishaki A, Tsutsui H.

    J Arrhythm. 2021 Jan 19;37(2):331-337.   2021.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Non-Pulmonary Vein Triggers of Atrial Fibrillation Are Likely to Arise from Low-Voltage Areas in the Left Atrium Reviewed International journal

    Shunsuke Kawai, Yasushi Mukai, Shujiro Inoue, Daisuke Yakabe, Kazuhiro Nagaoka, Kazuo Sakamoto, Susumu Takase, Akiko Chishaki, Hiroyuki Tsutsui

    Sci Rep. 2019 Aug 22;9(1):12271.   2019.8

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    Language：English   Publishing type：Research paper (scientific journal)  

  • D-dimer is helpful for differentiating acute aortic dissection and acute pulmonary embolism from acute myocardial infarction. Invited Reviewed International journal

    Sakamoto K, Yamamoto Y, Okamatsu H, Okabe M.

    Hellenic J Cardiol. 2011 Mar-Apr;52(2):123-7.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Predictive value of the induction test with atrial burst pacing with regard to long-term recurrence after ablation in persistent atrial fibrillation. Invited Reviewed International journal

    Kawai S, Mukai Y, Inoue S, Yakabe D, Nagaoka K, Sakamoto K, Takase S, Chishaki A, Tsutsui H.

    J Arrhythm. 2019 Jan 18;35(2):223-229.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Clinical characteristics and prognostic factors in acute coronary syndrome patients complicated with cardiogenic shock in Japan: analysis from the Japanese Circulation Society Cardiovascular Shock Registry. Invited Reviewed International journal

    Sakamoto K, Matoba T, Mohri M, Ueki Y, Tsujita Y, Yamasaki M, Tanaka N, Hokama Y, Fukutomi M, Hashiba K, Fukuhara R, Suwa S, Matsuura H, Tachibana E, Yonemoto N, Nagao K.

    Heart Vessels. 2019 Feb 4. doi: 10.1007/s00380-019-01354-9.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Very late perforation by a Riata implantable cardioverter-defibrillator lead-A case report. Invited Reviewed International journal

    Nozoe M, Sakamoto K, Nagatomo D, Suematsu N, Kubota T, Okabe M, Yamamoto Y.

    J Arrhythm. 2018 Mar 30;34(3):319-321.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Successful bipolar ablation for ventricular tachycardia with potential substrate identification by pre-procedural cardiac magnetic resonance imaging. Invited Reviewed International journal

    Sakamoto K, Nozoe M, Tsutsui Y, Suematsu N, Kubota T, Okabe M, Yamamoto Y.

    Int Med Case Rep J. 2017 May 11;10:167-171.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure. Invited Reviewed International journal

    Arimura T, Saku K, Kakino T, Nishikawa T, Tohyama T, Sakamoto T, Sakamoto K, Kishi T, Ide T, Sunagawa K.

    Int J Cardiol. 2017 Jan 15;227:704-710.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Prediction of hemodynamics under left ventricular assist device. Invited Reviewed International journal

    Kakino T, Saku K, Sakamoto T, Sakamoto K, Akashi T, Ikeda M, Ide T, Kishi T, Tsutsui H, Sunagawa K.

    Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H80-H88.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Optimal Titration Is Important to Maximize the Beneficial Effects of Vagal Nerve Stimulation in Chronic Heart Failure. Invited Reviewed International journal

    Nishizaki A, Sakamoto K, Saku K, Hosokawa K, Sakamoto T, Oga Y, Akashi T, Murayama Y, Kishi T, Ide T, Sunagawa K.

    J Card Fail. 2016 Aug;22(8):631-8.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction. Invited Reviewed International journal

    Saku K, Kakino T, Arimura T, Sakamoto T, Nishikawa T, Sakamoto K, Ikeda M, Kishi T, Ide T, Sunagawa K.

    PLoS One. 2016 Apr 28;11(4):e0152911.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. Invited Reviewed International journal

    Sakamoto K, Hosokawa K, Saku K, Sakamoto T, Tobushi T, Oga Y, Kishi T, Ide T, Sunagawa K.

    Am J Physiol Heart Circ Physiol. 2016 Jan 15;310(2):H199-205.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Prediction of the impact of venoarterial extracorporeal membrane oxygenation on hemodynamics. Invited Reviewed International journal

    Sakamoto K, Saku K, Kishi T, Kakino T, Tanaka A, Sakamoto T, Ide T, Sunagawa K.

    Am J Physiol Heart Circ Physiol. 2015 Apr 15;308(8):H921-30.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure. Invited Reviewed International journal

    Sakamoto T, Kakino T, Sakamoto K, Tobushi T, Tanaka A, Saku K, Hosokawa K, Onitsuka K, Murayama Y, Tsutsumi T, Ide T, Sunagawa K.

    Am J Physiol Heart Circ Physiol. 2015 Jan 1;308(1):H49-58.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity. Invited Reviewed International journal

    Saku K, Kishi T, Sakamoto K, Hosokawa K, Sakamoto T, Murayama Y, Kakino T, Ikeda M, Ide T, Sunagawa K.

    Physiol Rep. 2014 Sep 4;2(9). pii: e12136.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Cardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation. Invited Reviewed International journal

    Onitsuka K, Ide T, Arai S, Hata Y, Murayama Y, Hosokawa K, Sakamoto T, Tobushi T, Sakamoto K, Fujino T, Sunagawa K.

    J Mol Cell Cardiol. 2013 Nov;64:30-8.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Bionic baroreceptor corrects postural hypotension in rats with impaired baroreceptor. Invited Reviewed International journal

    Hosokawa K, Ide T, Tobushi T, Sakamoto K, Onitsuka K, Sakamoto T, Fujino T, Saku K, Sunagawa K.

    Circulation. 2012 Sep 4;126(10):1278-85.   2019.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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Books

  • 心原性ショック　最強の教科書

    坂本和生　的場哲哉

    2024.3 

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    Language：Japanese  

  • 臨床雑誌　内科　ここまで来た不整脈治療

    坂本和生

    2023.11 

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    Language：Japanese  

  • Heart View デジタル医療で循環器診療はどう変わる？

    坂本和生　遠山岳詩

    2023.8 

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    Language：Japanese  

  • Heart View 最強の心原性ショックチームを作ろう

    坂本和生　的場哲哉　筒井裕之

    2023.1 

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    Language：Japanese  

  • 不整脈の考えかた、治しかた

    坂本和生、向井 靖（ Role： Joint author）

    中外医学社  2019.7 

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    Responsible for pages：p100-104.   Language：Japanese   Book type：Scholarly book

Presentations

  • クリニカルパスによる心血管カテーテル診療における医師業務負担軽減

    坂本和生 的場哲哉 若田好史 山下貴範 佐藤寿彦 副島秀久 中島直樹

    日本内科学会第344回九州地方会  2024.1 

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    Event date： 2024.5

    Language：Japanese  

    Country：Japan  

  • 心不全における不整脈の重要性とカテーテルアブレーションの進歩

    坂本和生

    第135回日本循環器学会九州地方会  2023.12 

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    Event date： 2024.5

    Language：Japanese  

    Country：Japan  

  • Changing Physician Practice using the ePath system to reduce the clinical burden

    2023.3 

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    Event date： 2023.5

    Language：Japanese  

    Country：Japan  

  • 心臓突然死予防~最終治療方針決定までのストラテジー～

    坂本和生

    第2回日本不整脈心電学会九州・沖縄支部地方会  2022.4 

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    Event date： 2023.5

    Language：Japanese  

    Country：Japan  

  • Intravenous Vagal Stimulation Catheter, JOHAKU, Rapidly Induces Bradycardia Without Worsening Hemodynamics

    2022.6 

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    Event date： 2023.5

    Language：English  

    Country：Japan  

  • CHDに対する経静脈ペーシングの実際

    坂本和生

    第14回植え込みデバイス関連冬季大会  2022.2 

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    Event date： 2022.6

    Language：Japanese  

    Country：Japan  

  • 心房細動のインパクト。心房細動治療のインパクト。 Invited

    坂本和生

    第11回失神研究会  2021.7 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 大学病院で治療するACHDの不整脈

    坂本和生

    第131回日本循環器学会九州地方会  2021.12 

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    Event date： 2022.6

    Language：Japanese  

    Country：Japan  

  • 自動化が進むデバイス治療　-iATPへの期待- Invited

    坂本和生

    第1回日本不整脈心電学会九州・沖縄支部地方会  2021.4 

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    Event date： 2021.4

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 運動療法による心房細動の改善効果（アブレーション後の生活指導も含めて）

    坂本和生

    第26回日本心臓リハビリテーション学会学術集会  2020.7 

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    Event date： 2020.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 心房中隔欠損症に合併した心房細動に対するカテーテルアブレーションの心負荷軽減効果

    坂本和生, 向井靖, 高瀬進, 長岡和宏, 河合俊輔, 矢加部大輔, 井上修二朗, 渡邊高徳, 坂本一郎, 石北綾子, 梅本真太郎, 樗木晶子, 筒井裕之

    第21回日本成人先天性心疾患学会総会・学術集会  2020.1 

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • Inconsistent left atrial voltage map obtained either by a duo-decapolar spiral catheter or a novel omnipolar, directionality-accounted catheter (HD-grid) in Atrial Fibrillation.

    Sakamoto K, Tsutsui Y, Mukai Y, Nagaoka K, Kawai S, Mori R, Ikeda S, Yakabe D, Inoue S, Chishaki A, Tsutsui H

    2019.7 

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    Event date： 2020.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • The impact of stepwise intervention of catheter ablation and transcatheter closure for atrial septal defect patients complicated with atrial fibrillation. International conference

    Sakamoto K, Mukai Y, Nagaoka K, Kawai S Inoue S, Yakabe D, Ikeda S, Chishaki A, Tsutsui H

    The 12th Asia-Pacific Heart Rhythm Society Scientific Meeting (APHRS) 2019  2019.10 

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    Event date： 2020.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 房室中隔欠損症修復術後の心房頻拍に対して心房ペースマップが有効であった1例.

    坂本 和生, 向井 靖, 長岡 和宏, 河合 俊輔, 今給黎 智美, 池田 翔大, 樗木 晶子.

    2018.11 

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    Event date： 2019.6

    Language：Japanese  

    Country：Japan  

  • Clinical Impact of the Therapeutic Period of Percutaneous Cardiopulmonary Support: Analysis from JROAD-DPC

    Kazuo Sakamoto, Tetsuya Matoba, Kenzo Ichimura, Yoshio Tawara, Ken Nagao for the JCS Shock Registry Scientific Committee.

    2018.4 

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    Event date： 2019.6

    Language：Japanese  

    Country：Japan  

  • A Simple Criteria by Intra-atrial Activation Sequence to Localize Non-pulmonary Vein Foci During Catheter Ablation for Atrial Fibrillation

    Kazuo Sakamoto, Yasushi Mukai, Shunsuke Kawai, Kazuhiro Nagaoka, Shota Ikeda, Shujirou Inoue, Akiko Chishaki, Hiroyuki Tsutsui.

    2019.3 

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    Event date： 2019.6

    Language：Japanese  

    Country：Japan  

  • Transseptal Approach is Feasible and Effective in Ablating Ventricular Tachycardia Originating from Left Ventricle

    Kazuo Sakamoto, Yasushi Mukai, Shunsuke Kawai, Kazuhiro Nagaoka, Shota Ikeda, Shujirou Inoue, Akiko Chishaki, Hiroyuki Tsutsui.

    2019.3 

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    Event date： 2019.6

    Language：Japanese  

    Country：Japan  

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MISC

  • 特発性心室細動の心室細動再発による心臓突然死予防にLifeVestが有効であった症例

    坂本和生

    除細動ケースレポート, 旭化成ゾールメディカル   2020.12

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

Industrial property rights

Patent   Number of applications: 0   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本成人先天性心疾患学会

  • 日本不整脈学会

  • 日本循環器学会

  • 日本内科学会

Committee Memberships

  • Councilor   Domestic

    2020.9 - 2024.7   

Research Projects

  • Brugada症候群の突然死リスクを同定する経カテーテル的迷走神経刺激検査の開発

    2023

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    Grant type：Contract research

  • 心房細動において非不整脈時の生体情報から至適心筋焼灼部位を詮索する機械学習の開発

    2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 心房細動において非不整脈時の生体情報から至適心筋焼灼部位を詮索する機械学習の開発

    Grant number：22K08185  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 難治性心房細動に対する経皮的カテーテル心筋焼灼術における「神の目」と「神の技」を具現化するための電気生理所見および治療データの収集基盤構築と利活用のための研究

    2021 - 2023

    メディカルアーツ研究事業との連携による「循環器疾患・糖尿病等生活習慣病対策実用化研究事業」

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    Authorship：Principal investigator  Grant type：Contract research

  • Fontan術後の突然死高リスク患者における電気生理学的特性の解明

    2019 - 2021

    日本学術振興会  科学研究費助成事業  若手研究

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    Grant type：Scientific research funding

  • Fontan術後の突然死高リスク患者における電気生理学的特性の解明

    Grant number：19K17530  2019 - 2021

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 収縮能の保たれた心不全発症と動脈圧反射機能不全の生理学的/統計学的関係性

    2015 - 2016

    日本学術振興会  科学研究費助成事業  若手研究

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    Grant type：Scientific research funding

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Class subject

  • 循環器「心電図」

    2023.10 - 2024.3   Second semester

  • 循環器・呼吸器・造血器概論（臨床医学Ⅲ-②）「不整脈」

    2023.4 - 2023.9   First semester

  • 生理機能検査学

    2023.4 - 2023.9   First semester

  • 循環器「心電図」

    2021.10 - 2022.3   Second semester

  • 循環器・呼吸器・造血器概論（臨床医学Ⅲ-②）「不整脈」

    2021.4 - 2021.9   First semester

  • 生理機能検査学

    2021.4 - 2021.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • American Heart Association BLS Provider Courseインストラクターとして一般医療従事者向けの心肺蘇生教育を行っている。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Cardiology

Clinician qualification

  • Specialist

    The Japanese Society of Internal Medicine（JSIM）

  • Certifying physician

    日本心血管インターベンション学会

  • Specialist

    日本循環器学会

  • Specialist

    日本不整脈心電学会

Year of medical license acquisition

  • 2004

Notable Clinical Activities

  • 各患者さん毎の最適な医療の提供を目指す