Updated on 2024/06/10

Information

 

写真a

 
NAKANO TOSHIAKI
 
Organization
Kyushu University Hospital Kidney Care Unit Associate Professor
Title
Associate Professor
Contact information
メールアドレス
Tel
0926425843
Profile
九州大学病院に入院する腎炎、ネフローゼ症候群、腎不全患者の治療と、入院中の患者の腎不全や輸液のコンサルテーションを行っています。 血液透析、腹膜透析の導入、指導、合併症治療を行っています。 腎移植患者の術前精査、拒絶の精査、合併症治療を行っています。
External link

Degree

  • Doctor of Philosophy

Research Interests・Research Keywords

  • Research theme:Iron metabolism and renal prognosis in CKD patients

    Keyword:Iron metabolism

    Research period: 2023.5 - 2026.5

  • Research theme:Renal protective effect of inhibition of ferroptosis in tubulointerstitium via SGLT2

    Keyword:Tubulointerstitium

    Research period: 2021.6 - 2025.6

  • Research theme:Pathophysiology of focal segmental glomerular sclerosis

    Keyword:focal segmental glomerular sclerosis

    Research period: 2020.4 - 2025.3

  • Research theme:Dyslipidemia and cardiovascular disease in CKD

    Keyword:cholesterol

    Research period: 2018.4 - 2025.4

  • Research theme:The mechanism of indoxyl sulfate induced cardiac hypertrophy

    Keyword:indoxyl sulfate

    Research period: 2018.4 - 2022.4

  • Research theme:Pathopysiology of atherosclerosis and angiogenesis in chronic kidney disease

    Keyword:atherosclerosis, angiogenesis

    Research period: 2010.5 - 2022.5

Awards

  • 令和3年度日本透析医学会賞(木本賞)受賞

    2021.6   日本透析医学会  

  • 第26回日本腹膜透析医学会優秀演題賞

    2020.9   日本腹膜透析医学会  

  • 第50回日本動脈硬化学会優秀演題賞

    2018.7   日本動脈硬化学会  

  • 第2回Uremic Toxin研究会最優秀演題賞

    2018.3   Uremic Toxin研究会  

  • 第54回日本腎臓学会優秀演題賞

    2011.6   第54回日本腎臓学会学術総会  

Papers

  • Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Invited Reviewed International journal

    Circulation. 2019 Jan 2;139(1):78-96.   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study Reviewed International journal

    Toshiaki Nakano, Toshiharu Ninomiya, Shinji Sumiyoshi, Mitsuho Onimaru, Hiroshi Fujii, Hiroyuki Itabe, Yutaka Nakashima, Katsuo Sueishi, Kazuhiko Tsuruya, Yoshinao Oda, Takanari Kitazono, Yutaka Kiyohara

    Kidney Int. 2013 Aug;84(2):373-80.   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ki.2013.111.

  • Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. International journal

    Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, Tsuruya K, Iida M, Kiyohara Y, Sueishi K.

    Am J Kidney Dis. 2010 Jan;55(1):21-30.   55 ( 1 )   2010.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Angiogenesis and lymphangiogenesis and expression of lymphangiogenic factors in the atherosclerotic intima of human coronary arteries. International journal

    Nakano T, Nakashima Y, Yonemitsu Y, Sumiyoshi S, Chen YX, Akishima Y, Ishii T, Iida M, Sueishi K.

    Hum Pathol. 2005 Apr;36(4):330-340.   36 ( 4 )   330 - 340   2005.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2005.01.001

  • History of fragility fracture is associated with cardiovascular mortality in hemodialysis patients: the Q-Cohort study.

    Naoki Haruyama, Masaru Nakayama, Shunsuke Yamada, Shigeru Tanaka, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano

    Journal of bone and mineral metabolism   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00774-024-01501-x

  • Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study.

    Toshiaki Nakano, Hiromasa Kitamura, Jun Hata, Kenji Maki, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    Journal of atherosclerosis and thrombosis   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.64394

  • Association between Hemoglobin A1c and Renal Arteriolar Sclerosis in Subjects Presenting without any Apparent Kidney Dysfunction.

    Yuta Matsukuma, Akihiro Tsuchimoto, Kosuke Masutani, Kenji Ueki, Shigeru Tanaka, Naoki Haruyama, Yasuhiro Okabe, Masafumi Nakamura, Takanari Kitazono, Toshiaki Nakano

    Journal of atherosclerosis and thrombosis   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.64236

  • More rapid progression of brain atrophy in patients on peritoneal dialysis compared with hemodialysis: The VCOHP Study. International journal

    Kazuhiko Tsuruya, Hisako Yoshida, Shunsuke Yamada, Naoki Haruyama, Shigeru Tanaka, Akihiro Tsuchimoto, Masahiro Eriguchi, Kiichiro Fujisaki, Kumiko Torisu, Toshiaki Nakano, Kosuke Masutani, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-023-01530-5

  • 腎障害とエネルギー・代謝研究の新たな展開 アルギニン代謝を通して腎保護を考える

    鳥巣 久美子, 相原 成志, 内田 裕士, 中野 敏昭

    日本腎臓学会誌   65 ( 6-W )   742 - 742   2023.9

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    Language:Japanese  

  • Arginase 2 Promotes Cisplatin-Induced Acute Kidney Injury by the Inflammatory Response of Macrophages. International journal

    Yushi Uchida, Kumiko Torisu, Seishi Aihara, Noriyuki Imazu, Hiroaki Ooboshi, Takanari Kitazono, Toshiaki Nakano

    Laboratory investigation; a journal of technical methods and pathology   103 ( 10 )   100227 - 100227   2023.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.labinv.2023.100227

  • Acrolein produced during acute kidney injury promotes tubular cell death. International journal

    Seishi Aihara, Kumiko Torisu, Yutaro Hirashima, Takanari Kitazono, Toshiaki Nakano

    Biochemical and biophysical research communications   666   137 - 145   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2023.05.029

  • Association between Serum C-Reactive Protein Concentrations and Risk of Cancer-Related Mortality in Patients Undergoing Hemodialysis: 10-Year Outcomes of the Q-Cohort Study. International journal

    Yushi Uchida, Toshiaki Nakano, Hiroto Hiyamuta, Hiromasa Kitamura, Masatomo Taniguchi, Hiroaki Ooboshi, Kazuhiko Tsuruya, Takanari Kitazono

    Blood purification   1 - 8   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000530846

  • Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis. International journal

    Seishi Aihara, Kumiko Torisu, Yushi Uchida, Noriyuki Imazu, Toshiaki Nakano, Takanari Kitazono

    Communications biology   6 ( 1 )   676 - 676   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-023-05057-w

  • Cumulative smoking dose is associated with subclinical renal injury: a pathological study in individuals without chronic kidney disease

    Eri Ataka, Yuta Matsukuma, Kenji Ueki, Akihiro Tsuchimoto, Yasuhiro Okabe, Kosuke Masutani, Masafumi Nakamura, Toshiaki Nakano, Takanari Kitazono

    Nephrology Dialysis Transplantation   2023.6

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfad124

  • Normalization of progressive increases in serum myeloperoxidase-anti-neutrophil cytoplasmic antibody titers after breast cancer resection in a patient with clinically stable microscopic polyangiitis

    Shunsuke Yamada, Manako Takesako, Takanari Kitazono, Toshiaki Nakano

    CEN CASE REPORTS   2023.5

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    Language:English  

    DOI: 10.1007/s13730-023-00793-8

  • アルギナーゼ2はシスプラチン誘発急性腎障害においてマクロファージの炎症応答を促進する

    内田 裕士, 鳥巣 久美子, 相原 成志, 大星 博明, 中野 敏昭, 北園 孝成

    日本腎臓学会誌   65 ( 3 )   298 - 298   2023.5

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    Language:Japanese  

  • Time to Shift our Mindset to a Phosphate-Centric Approach for Prevention of Cardiovascular Calcification in the Dialysis Population

    Shunsuke Yamada, Toshiaki Nakano

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   2023.4

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    Language:English  

    DOI: 10.5551/jat.ED234

  • Simplified geriatric nutritional risk index for assessing nutritional status and stratifying mortality risk in patients receiving maintenance hemodialysis

    Shunsuke Yamada, Hokuto Arase, Masatomo Taniguchi, Takanari Kitazono, Toshiaki Nakano

    THERAPEUTIC APHERESIS AND DIALYSIS   27 ( 2 )   253 - 263   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1744-9987.13908

  • Clinical Features of Gastroduodenal Ulcers in Kidney Transplant Patients.

    Masahiro Kondo, Takehiro Torisu, Yutaro Ihara, Keisuke Kawasaki, Junji Umeno, Shinichiro Kawatoko, Akihiro Tsuchimoto, Toshiaki Nakano, Yasuhiro Okabe, Takanari Kitazono

    Internal medicine (Tokyo, Japan)   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.1508-22

  • Association between microscopic hematuria and albuminuria in patients with chronic kidney disease caused by diabetes and hypertension: the Fukuoka Kidney disease Registry Study.

    Kaneyasu Nakagawa, Shigeru Tanaka, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano

    Clinical and experimental nephrology   27 ( 3 )   227 - 235   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-022-02298-7

  • Design and methods of an open-label, randomized controlled trial to evaluate the effect of pemafibrate on proteinuria in CKD patients (PROFIT-CKD).

    Mai Seki, Toshiaki Nakano, Shigeru Tanaka, Yuta Matsukuma, Kouta Funakoshi, Toshiaki Ohkuma, Takanari Kitazono

    Clinical and experimental nephrology   27 ( 4 )   358 - 364   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-023-02322-4

  • Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study.

    Hiromasa Kitamura, Shigeru Tanaka, Hiroto Hiyamuta, Sho Shimamoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Journal of atherosclerosis and thrombosis   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.63891

  • Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells.

    Seishi Aihara, Toshiaki Nakano, Kumiko Torisu, Takanari Kitazono

    Clinical and experimental nephrology   26 ( 12 )   1160 - 1169   2022.12

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    DOI: 10.1007/s10157-022-02272-3

  • Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia. International journal

    Akinori Hara, Takashi Wada, Eri Muso, Shoichi Maruyama, Sawako Kato, Kengo Furuichi, Kenichi Yoshimura, Tadashi Toyama, Norihiko Sakai, Hiroyuki Suzuki, Tatsuo Tsukamoto, Mariko Miyazaki, Eiichi Sato, Masanori Abe, Yugo Shibagaki, Ichiei Narita, Shin Goto, Yuichi Sakamaki, Hitoshi Yokoyama, Noriko Mori, Satoshi Tanaka, Yukio Yuzawa, Midori Hasegawa, Takeshi Matsubara, Jun Wada, Katsuyuki Tanabe, Kosuke Masutani, Yasuhiro Abe, Kazuhiko Tsuruya, Shouichi Fujimoto, Shuji Iwatsubo, Akihiro Tsuda, Hitoshi Suzuki, Kenji Kasuno, Yoshio Terada, Takeshi Nakata, Noriaki Iino, Tadashi Sofue, Hitomi Miyata, Toshiaki Nakano, Takayasu Ohtake, Shuzo Kobayashi

    Blood purification   52 ( 4 )   1 - 9   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000527900

  • Serum alkaline phosphatase and infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-cohort study.

    Hiromasa Kitamura, Ryusuke Yotsueda, Hiroto Hiyamuta, Masatomo Taniguchi, Shigeru Tanaka, Shunsuke Yamada, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Clinical and experimental nephrology   26 ( 11 )   1119 - 1129   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-022-02255-4

  • Low intake of β carotene and dietary fiber from vegetables and fruits in patients with chronic kidney disease. International journal

    12 ( 1 )   19953 - 19953   2022.11

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    Patients with chronic kidney disease (CKD) occasionally need to restrict their consumption of vegetables and fruits. However, recent evidence suggests that plant-based diets have beneficial effects in patients with CKD. We aimed to determine the sufficiency of β carotene and dietary fiber intake in patients with CKD. We conducted a cross-sectional study among 4476 patients registered in the Fukuoka Kidney Disease Registry (FKR) study, a Japanese prospective cohort study of patients with CKD. Data from 3545 patients were analyzed after excluding cases with insufficient information. We evaluated the relationship between CKD stages and the intake of vegetables and fruits. The intake of β carotene and dietary fiber in CKD stages was evaluated using analysis of covariance. As the CKD stage advanced, the intake of vegetables, green leafy vegetables, and fruits significantly decreased (P-value for all trends < 0.01). The intake of vegetables significantly decreased as the CKD stage advanced (P for trend < 0.01). After adjusting for confounding factors, the intake of β carotene and dietary fiber also decreased (both P < 0.01) as the CKD stage advanced. Patients with CKD had insufficient vegetable and fruit intake and a lack of β carotene and dietary fiber from vegetables and fruits.

    DOI: 10.1038/s41598-022-24471-4

  • Genome-wide association study of the risk of chronic kidney disease and kidney-related traits in the Japanese population: J-Kidney-Biobank. Reviewed International journal

    Yuka Sugawara, Yosuke Hirakawa, Hajime Nagasu, Akira Narita, Akihiro Katayama, Jun Wada, Miho Shimizu, Takashi Wada, Hiromasa Kitamura, Toshiaki Nakano, Hideki Yokoi, Motoko Yanagita, Shin Goto, Ichiei Narita, Seizo Koshiba, Gen Tamiya, Masaomi Nangaku, Masayuki Yamamoto, Naoki Kashihara

    Journal of human genetics   68 ( 2 )   55 - 64   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s10038-022-01094-1

  • Current antihypertensive treatment and treatment-resistant hypertension in Japanese patients with chronic kidney disease.

    Akihiro Tsuchimoto, Shigeru Tanaka, Hiromasa Kitamura, Hiroto Hiyamuta, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano

    Clinical and experimental nephrology   26 ( 11 )   1100 - 1110   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-022-02250-9

  • Association between prevalence of laxative use and history of bone fractures and cardiovascular diseases in patients with chronic kidney disease: the Fukuoka Kidney disease Registry (FKR) study.

    Shunsuke Yamada, Shigeru Tanaka, Hokuto Arase, Hiroto Hiyamuta, Hiromasa Kitamura, Masanori Tokumoto, Koji Mitsuiki, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano

    Clinical and experimental nephrology   27 ( 2 )   151 - 160   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-022-02289-8

  • Association between hyporesponsiveness to erythropoiesis-stimulating agents and risk of brain hemorrhage in patients undergoing hemodialysis: the Q-Cohort Study.

    Yushi Uchida, Toshiaki Nakano, Hiromasa Kitamura, Masatomo Taniguchi, Kazuhiko Tsuruya, Takanari Kitazono

    Clinical and experimental nephrology   27 ( 1 )   79 - 88   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-022-02278-x

  • Treatment of chronic active T cell-mediated rejection after kidney transplantation: A retrospective cohort study of 37 transplants. International journal

    Hiroshi Noguchi, Yuta Matsukuma, Kaneyasu Nakagawa, Kenji Ueki, Akihiro Tsuchimoto, Toshiaki Nakano, Yu Sato, Keizo Kaku, Yasuhiro Okabe, Masafumi Nakamura

    Nephrology (Carlton, Vic.)   27 ( 7 )   632 - 638   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/nep.14048

  • The Association of Controlling Nutritional Status Score and Prognostic Nutritional Index with Cardiovascular Diseases: the Fukuoka Kidney Disease Registry Study.

    Susumu Tsuda, Masaru Nakayama, Shigeru Tanaka, Naoki Haruyama, Ryota Yoshitomi, Akiko Fukui, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Journal of atherosclerosis and thrombosis   30 ( 4 )   390 - 407   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.63501

  • Serum Alkaline Phosphatase Levels and Increased Risk of Brain Hemorrhage in Hemodialysis Patients: The Q-Cohort Study.

    Hiromasa Kitamura, Shunsuke Yamada, Hiroto Hiyamuta, Ryusuke Yotsueda, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Journal of atherosclerosis and thrombosis   29 ( 6 )   923 - 936   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.62885

  • Retroperitoneal Hemorrhage in Patients with COVID-19 Undergoing Hemodialysis: Three Case Reports.

    Hideaki Oka, Yoshito Homma, Yuki Nishino, Koichiro Suemori, Norio Sato, Yuko Sakurai, Mizuki Sekimoto, Shota Ando, Saki Iwamoto, Takaki Iwamoto, Mika Kondo, Taro Kamimura, Toshiaki Nakano, Takanari Kitazono

    Internal medicine (Tokyo, Japan)   61 ( 12 )   1869 - 1876   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.8976-21

  • Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification. International journal

    Hokuto Arase, Shunsuke Yamada, Kumiko Torisu, Masanori Tokumoto, Masatomo Taniguchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Calcified tissue international   110 ( 6 )   685 - 697   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00223-022-00947-3

  • Prevalence, treatment status, and predictors of anemia and erythropoietin hyporesponsiveness in Japanese patients with non-dialysis-dependent chronic kidney disease: a cross-sectional study.

    Shigeru Tanaka, Hiromasa Kitamura, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano

    Clinical and experimental nephrology   26 ( 9 )   867 - 879   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-022-02227-8

  • Comparison of the predictability of serum creatinine-based surrogates of skeletal muscle mass for all-cause mortality in patients receiving hemodialysis: creatinine generation rate and creatinine index

    Shunsuke Yamada, Hokuto Arase, Masatomo Taniguchi, Takanari Kitazono, Toshiaki Nakano

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   26 ( 5 )   488 - 489   2022.5

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    Language:English  

    DOI: 10.1007/s10157-021-02175-9

  • A case of peritoneal dialysis-related peritonitis caused by dialysate leakage with successful treatment by intravenous and intraperitoneal antibiotic therapy.

    Kenji Ueki, Akihiro Tsuchimoto, Kumiko Torisu, Kiichiro Fujisaki, Sayaka Tachibana, Keigo Tomita, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CEN case reports   11 ( 2 )   161 - 165   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13730-021-00644-4

  • Malnutrition-Inflammation Complex Syndrome and Bone Fractures and Cardiovascular Disease Events in Patients Undergoing Hemodialysis: The Q-Cohort Study. International journal

    Shunsuke Yamada, Hokuto Arase, Hisako Yoshida, Hiromasa Kitamura, Masanori Tokumoto, Masatomo Taniguchi, Hideki Hirakata, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Kidney medicine   4 ( 3 )   100408 - 100408   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.xkme.2022.100408

  • Emerging cross-talks between chronic kidney disease-mineral and bone disorder (CKD-MBD) and malnutrition-inflammation complex syndrome (MICS) in patients receiving dialysis

    Shunsuke Yamada, Kazuhiko Tsuruya, Takanari Kitazono, Toshiaki Nakano

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   26 ( 7 )   613 - 629   2022.3

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    Language:English  

    DOI: 10.1007/s10157-022-02216-x

  • A non-immunocompromised host with nontuberculous mycobacteria-associated tubulointerstitial nephritis.

    Soken Hattori, Kiichiro Fujisaki, Yusuke Nakamata, Takuro Kometani, Takafumi Nakashima, Kazuki Koga, Sho Sasaki, Ryosuke Yamate, Takashi Matono, Akihiro Tsuchimoto, Toshiaki Nakano

    CEN case reports   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13730-022-00690-6

  • Sex differences in the 10-year survival of patients undergoing maintenance hemodialysis in the Q-Cohort Study. International journal

    Hiroaki Tsujikawa, Shunsuke Yamada, Hiroto Hiyamuta, Masatomo Taniguchi, Kazuhiko Tsuruya, Kumiko Torisu, Toshiaki Nakano, Takanari Kitazono

    Scientific reports   12 ( 1 )   345 - 345   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-03551-x

  • Clinical epidemiological analysis of cohort studies investigating the pathogenesis of kidney disease.

    Shigeru Tanaka, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Clinical and experimental nephrology   26 ( 1 )   1 - 12   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-021-02121-9

  • Association of the nutritional risk index for Japanese hemodialysis patients with long-term mortality: The Q-Cohort Study.

    Sho Shimamoto, Shunsuke Yamada, Hiroto Hiyamuta, Hokuto Arase, Masatomo Taniguchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Clinical and experimental nephrology   26 ( 1 )   59 - 67   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-021-02124-6

  • Pathologic Diabetic Nephropathy in Autopsied Diabetic Cases With Normoalbuminuria From a Japanese Community-Based Study. International journal

    Takaya Sasaki, Kaneyasu Nakagawa, Jun Hata, Yoichiro Hirakawa, Mao Shibata, Toshiaki Nakano, Nobuo Tsuboi, Yoshinao Oda, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya

    Kidney international reports   6 ( 12 )   3035 - 3044   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ekir.2021.09.007

  • Association between the urinary sodium-to-potassium ratio and renal outcomes in patients with chronic kidney disease: a prospective cohort study. International journal

    Yuta Matsukuma, Masaru Nakayama, Susumu Tsuda, Akiko Fukui, Ryota Yoshitomi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 11 )   1492 - 1504   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-021-00741-y

  • Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells. International journal

    Yushi Uchida, Kumiko Torisu, Kenji Ueki, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    American journal of physiology. Renal physiology   321 ( 5 )   F572-F586 - F586   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajprenal.00172.2021

  • Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database. International journal

    Hajime Nagasu, Yuichiro Yano, Hiroshi Kanegae, Hiddo J L Heerspink, Masaomi Nangaku, Yosuke Hirakawa, Yuka Sugawara, Naoki Nakagawa, Yuji Tani, Jun Wada, Hitoshi Sugiyama, Kazuhiko Tsuruya, Toshiaki Nakano, Shoichi Maruyama, Takashi Wada, Kunihiro Yamagata, Ichiei Narita, Kouichi Tamura, Motoko Yanagita, Yoshio Terada, Takashi Shigematsu, Tadashi Sofue, Takafumi Ito, Hirokazu Okada, Naoki Nakashima, Hiromi Kataoka, Kazuhiko Ohe, Mihoko Okada, Seiji Itano, Akira Nishiyama, Eiichiro Kanda, Kohjiro Ueki, Naoki Kashihara

    Diabetes care   44 ( 11 )   2542 - 2551   2021.11

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    DOI: 10.2337/dc21-1081

  • Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD.

    Shigeru Tanaka, Toshiaki Nakano, Hiroto Hiyamuta, Kazuhiko Tsuruya, Takanari Kitazono

    Journal of atherosclerosis and thrombosis   29 ( 8 )   1249 - 1264   2021.10

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    DOI: 10.5551/jat.62900

  • Roles of Sodium-Glucose Cotransporter 2 of Mesangial Cells in Diabetic Kidney Disease. International journal

    Masanori Wakisaka, Kuniyuki Nakamura, Toshiaki Nakano, Takanari Kitazono

    Journal of the Endocrine Society   5 ( 8 )   bvab083   2021.8

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    DOI: 10.1210/jendso/bvab083

  • Subclinical hypothyroidism is independently associated with poor renal outcomes in patients with chronic kidney disease

    Susumu Tsuda, Masaru Nakayama, Yuta Matsukuma, Ryota Yoshitomi, Naoki Haruyama, Akiko Fukui, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    ENDOCRINE   73 ( 1 )   141 - 150   2021.7

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    DOI: 10.1007/s12020-021-02611-6

  • Causes of death in patients undergoing maintenance hemodialysis in Japan: 10-year outcomes of the Q-Cohort Study

    Hiroto Hiyamuta, Shunsuke Yamada, Masatomo Taniguchi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   2021.6

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    DOI: 10.1007/s10157-021-02089-6

  • High low-density lipoprotein cholesterol as an independent risk factor for coronary restenosis in hemodialysis patients undergoing percutaneous coronary interventions

    Shoko Hasegawa, Toshiaki Nakano, Yasushi Mukai, Yuta Matsukuma, Ryusuke Yotsueda, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kazuhiko Tsuruya, Hiroyuki Tsutsui, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   25 ( 3 )   296 - 303   2021.6

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    DOI: 10.1111/1744-9987.13558

  • Clinicopathological significance of light chain deposition in IgA nephropathy

    Ritsuko Katafuchi, Hiroshi Nagae, Kosuke Masutani, Toshiaki Nakano, Mikio Munakata, Kazuhiko Tsuruya, Koji Mitsuiki

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   25 ( 6 )   621 - 632   2021.6

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    DOI: 10.1007/s10157-021-02026-7

  • Association between geriatric nutritional risk index and stroke risk in hemodialysis patients: 10-Years outcome of the Q-Cohort study

    Shoji Tsuneyoshi, Yuta Matsukuma, Yasuhiro Kawai, Hiroto Hiyamuta, Shunsuke Yamada, Hiromasa Kitamura, Shigeru Tanaka, Masatomo Taniguchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    ATHEROSCLEROSIS   323   30 - 36   2021.4

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    DOI: 10.1016/j.atherosclerosis.2021.03.006

  • Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study

    Keisuke Yamasaki, Jun Hata, Tomomi Ide, Takuya Nagata, Satoko Sakata, Daigo Yoshida, Takanori Honda, Yoichiro Hirakawa, Toshiaki Nakano, Takanari Kitazono, Hiroyuki Tsutsui, Toshiharu Ninomiya

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   26 ( 1 )   2021.4

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    DOI: 10.1186/s12199-021-00970-0

  • Stronger Effect of Azilsartan on Reduction of Proteinuria Compared to Candesartan in Patients with CKD: A Randomized Crossover Trial

    Takaichi Suehiro, Kazuhiko Tsuruya, Hisako Yoshida, Hiroaki Tsujikawa, Shunsuke Yamada, Shigeru Tanaka, Akihiro Tsuchimoto, Masahiro Eriguchi, Kiichiro Fujisaki, Kumiko Torisu, Toshiaki Nakano, Takanari Kitazono

    KIDNEY & BLOOD PRESSURE RESEARCH   46 ( 2 )   173 - 184   2021.4

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    DOI: 10.1159/000512365

  • Relationship between serum lipid concentrations and impaired renal function in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry Study

    Toshiaki Nakano, Shigeru Tanaka, Kazuhiko Tsuruya, Takanari Kitazono

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   25 ( 4 )   385 - 393   2021.4

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    DOI: 10.1007/s10157-020-02000-9

  • Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study

    Masatoshi Hara, Shigeru Tanaka, Kumiko Torisu, Yuta Matsukuma, Akihiro Tsuchimoto, Masanori Tokumoto, Hiroaki Ooboshi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   2021.4

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    DOI: 10.1007/s10157-020-02018-z

  • Associations Between Surrogates of Skeletal Muscle Mass and History of Bone Fracture in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry (FKR) Study

    Shunsuke Yamada, Shigeru Tanaka, Hokuto Arase, Hiroto Hiyamuta, Eriko Yoshizumi, Masanori Tokumoto, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CALCIFIED TISSUE INTERNATIONAL   109 ( 4 )   393 - 404   2021.4

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    DOI: 10.1007/s00223-021-00851-2

  • Association of normalized protein catabolic rate (nPCR) with the risk of bone fracture in patients undergoing maintenance hemodialysis: The Q-Cohort Study

    Shotaro Ohnaka, Shunsuke Yamada, Hiroaki Tsujikawa, Hokuto Arase, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    CLINICAL NUTRITION   40 ( 3 )   997 - 1004   2021.3

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    DOI: 10.1016/j.clnu.2020.07.003

  • A case of Stappia indica-induced relapsing peritonitis confirmed by 16S ribosomal RNA gene sequencing analysis in a patient undergoing continuous ambulatory peritoneal dialysis

    Shunsuke Yamada, Yuri Sonoda, Kazunori Sugimachi, Haruka Toya, Keitaro Uehara, Yuri Shinagawa, Akihiro Tsuchimoto, Toshiaki Nakano, Takanari Kitazono

    CEN CASE REPORTS   10 ( 3 )   402 - 408   2021.2

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    DOI: 10.1007/s13730-021-00579-w

  • Rupture of a heavily calcified aortic arch in a patient with aortitis syndrome, advanced atherosclerosis, and renal ischemia: a dilemma between appropriate blood pressure control and maintenance of renal perfusion

    Shunsuke Yamada, Hideaki Oka, Kenichi Goto, Toshiaki Nakano, Takanari Kitazono

    CEN CASE REPORTS   10 ( 1 )   156 - 157   2021.2

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    DOI: 10.1007/s13730-020-00521-6

  • Development and validation of a risk score for the prediction of cardiovascular disease in living donor kidney transplant recipients

    Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Kaneyasu Nakagawa, Hiroaki Tsujikawa, Kosuke Masutani, Shigeru Tanaka, Keizo Kaku, Hiroshi Noguchi, Yasuhiro Okabe, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Masafumi Nakamura, Kazuhiko Tsuruya, Toshiaki Nakano, Kazunari Tanabe, Takanari Kitazono

    NEPHROLOGY DIALYSIS TRANSPLANTATION   36 ( 2 )   365 - 374   2021.2

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    DOI: 10.1093/ndt/gfaa275

  • Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study

    Akiko Fukui, Masaru Nakayama, Shigeru Tanaka, Yuta Matsukuma, Ryota Yoshitomi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   25 ( 1 )   9 - 18   2021.1

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    DOI: 10.1007/s10157-020-01950-4

  • Significance of revised criteria for chronic active T cell-mediated rejection in the 2017 Banff classification: Surveillance by 1-year protocol biopsies for kidney transplantation

    Kaneyasu Nakagawa, Akihiro Tsuchimoto, Kenji Ueki, Yuta Matsukuma, Yasuhiro Okabe, Kosuke Masutani, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Masafumi Nakamura, Toshiaki Nakano, Kazunari Tanabe, Takanari Kitazono

    AMERICAN JOURNAL OF TRANSPLANTATION   21 ( 1 )   174 - 185   2021.1

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    DOI: 10.1111/ajt.16093

  • Effects of LDL apheresis on proteinuria in patients with diabetes mellitus, severe proteinuria, and dyslipidemia

    Takashi Wada, Akinori Hara, Eri Muso, Shoichi Maruyama, Sawako Kato, Kengo Furuichi, Kenichi Yoshimura, Tadashi Toyama, Norihiko Sakai, Hiroyuki Suzuki, Tatsuo Tsukamoto, Mariko Miyazaki, Eiichi Sato, Masanori Abe, Yugo Shibagaki, Ichiei Narita, Shin Goto, Yuichi Sakamaki, Hitoshi Yokoyama, Noriko Mori, Yukio Yuzawa, Midori Hasegawa, Takeshi Matsubara, Jun Wada, Katsuyuki Tanabe, Kosuke Masutani, Yasuhiro Abe, Kazuhiko Tsuruya, Shouichi Fujimoto, Shuji Iwatsubo, Akihiro Tsuda, Hitoshi Suzuki, Kenji Kasuno, Yoshio Terada, Takeshi Nakata, Noriaki Iino, Tadashi Sofue, Hitomi Miyata, Toshiaki Nakano, Takayasu Ohtake, Shuzo Kobayashi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   25 ( 1 )   1 - 8   2021.1

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    DOI: 10.1007/s10157-020-01959-9

  • Comparison of Immunohistochemical Staining for Large T Antigen and Capsid Protein VP1 in BK Polyomavirus-Associated Nephropathy

    Kosuke Masutani, Yuta Matsukuma, Akihiro Tsuchimoto, Yasuhiro Okabe, Atsushi Doi, Keizo Kaku, Masafumi Nakamura, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    NEPHRON   144 ( SUPPL 1 )   28 - 36   2021.1

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    DOI: 10.1159/000510967

  • Association of hyperphosphatemia with an increased risk of sudden death in patients on hemodialysis: Ten-year outcomes of the Q-Cohort Study

    Hiroto Hiyamuta, Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    ATHEROSCLEROSIS   316   25 - 31   2021.1

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    DOI: 10.1016/j.atherosclerosis.2020.11.020

  • Geriatric Nutritional Risk Index (GNRI) and Creatinine Index Equally Predict the Risk of Mortality in Hemodialysis Patients J-DOPPS Reviewed

    Shunsuke Yamada, Shungo Yamamoto, Shingo Fukuma, Toshiaki Nakano, Kazuhiko Tsuruya, Masaaki Inaba

    Scientific reports   10 ( 1 )   2020.12

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    DOI: 10.1038/s41598-020-62720-6

  • Modified creatinine index and risk for long-term infection-related mortality in hemodialysis patients ten-year outcomes of the Q-Cohort Study Reviewed

    Hokuto Arase, Shunsuke Yamada, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Scientific reports   10 ( 1 )   2020.12

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    DOI: 10.1038/s41598-020-58181-6

  • Increased Risk of Infection-Related and All-Cause Death in Hypercalcemic Patients Receiving Hemodialysis The Q-Cohort Study Reviewed

    Shunsuke Yamada, Hokuto Arase, Masanori Tokumoto, Masatomo Taniguchi, Hisako Yoshida, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Scientific reports   10 ( 1 )   2020.12

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    DOI: 10.1038/s41598-020-63334-8

  • The first case of COVID-19 pneumonia in a hemodialysis patient in Japan

    Yusuke Kuroki, Kazutoshi Hiyama, Junya Minami, Miyoshi Takeuchi, Masumi Shojima, Shumei Matsueda, Hiroshi Nagae, Toshiaki Nakano

    CEN CASE REPORTS   9 ( 4 )   404 - 408   2020.11

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    DOI: 10.1007/s13730-020-00495-5

  • Estimated plasma osmolarity and risk of end-stage kidney disease in patients with IgA nephropathy Reviewed

    Shigeru Tanaka, Toshiaki Nakano, Masanori Tokumoto, Kosuke Masutani, Akihiro Tsuchimoto, Hiroaki Ooboshi, Takanari Kitazono

    Clinical and Experimental Nephrology   24 ( 10 )   910 - 918   2020.10

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    DOI: 10.1007/s10157-020-01919-3

  • Estimated plasma osmolarity and risk of end-stage kidney disease in patients with IgA nephropathy

    Shigeru Tanaka, Toshiaki Nakano, Masanori Tokumoto, Kosuke Masutani, Akihiro Tsuchimoto, Hiroaki Ooboshi, Takanari Kitazono

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   24 ( 10 )   910 - 918   2020.10

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    DOI: 10.1007/s10157-020-01919-3

  • ESTABLISHMENT OF A COMPREHENSIVE NATIONWIDE BIOBANK FOR KIDNEY DISEASES WITH DEEP GENETIC DATA, DETAILED CLINICAL INFORMATION AND BIOSPECIMENS

    Yosuke Hirakawa, Hajime Nagasu, Yuka Sugawara, Seizo Koshiba, Ichiei Narita, Takashi Wada, Motoko Yanagita, Jun Wada, Shoichi Maruyama, Toshiaki Nakano, Masayuki Yamamoto, Masaomi Nangaku, Naoki Kashihara

    NEPHROLOGY   25   70 - 70   2020.10

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  • Arginase 2 is a mediator of ischemia–reperfusion injury in the kidney through regulation of nitrosative stress Reviewed

    98 ( 3 )   673 - 685   2020.9

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    Kidney ischemia–reperfusion injury is a major cause of acute kidney injury (AKI). Following reduced kidney perfusion, the pathological overproduction of reactive oxygen and reactive nitrogen species play a substantial role in the development of kidney ischemia–reperfusion injury. Arginase 2 (ARG2) competes with nitric oxide synthase for the same substrate, L-arginine, and is implicated in the regulation of reactive nitrogen species. Therefore, we investigated the role of ARG2 in kidney ischemia–reperfusion injury using human proximal tubule cells (HK-2) and a mouse model of kidney ischemia–reperfusion injury. ARG2 was predominantly expressed in kidney tubules of the cortex, which was increased after ischemia–reperfusion injury. In HK-2 cells, ARG2 was expressed in punctate form in the cytoplasm and upregulated after hypoxia–reoxygenation. ARG2 knockdown reduced the level of reactive oxygen species and 3-nitrotyrosine after hypoxia–reoxygenation injury compared with control siRNA. Consistent with these results, in Arg2 knockout mice, abnormal kidney function and the increased acute tubular necrosis score induced by ischemia–reperfusion injury was significantly reduced without any obvious blood pressure changes. Additionally, an accumulation of 3-nitrotyrosine and apoptosis of renal tubule cells were attenuated in Arg2 knockout mice compared with wild-type mice. Inhibition of arginase by Nω-hydroxy-nor-L-arginine alleviated kidney ischemia–reperfusion injury like the results found in Arg2 knockout mice. Thus, ARG2 plays a pivotal role in ischemia–reperfusion-induced AKI by means of nitrosative stress. Hence, an ARG2-specific inhibitor may effectively treat kidney ischemia–reperfusion injury.

    DOI: 10.1016/j.kint.2020.03.032

  • Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress

    Masatoshi Hara, Kumiko Torisu, Keigo Tomita, Yasuhiro Kawai, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    KIDNEY INTERNATIONAL   98 ( 3 )   673 - 685   2020.9

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    DOI: 10.1016/j.kint.2020.03.032

  • Prophylactic Oral Antibiotics for Postendoscopic Peritonitis in Peritoneal Dialysis Reviewed

    Hideaki Oka, Kazuhiko Tsuruya, Toshiaki Nakano

    Therapeutic Apheresis and Dialysis   24 ( 4 )   462 - 463   2020.8

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    DOI: 10.1111/1744-9987.13442

  • Association between modified simple protein-energy wasting (PEW) score and all-cause mortality in patients receiving maintenance hemodialysis

    Shunsuke Yamada, Toshiaki Nakano, Shoji Tsuneyoshi, Hokuto Arase, Sho Shimamoto, Masatomo Taniguchi, Masanori Tokumoto, Hideki Hirakata, Hiroaki Ooboshi, Kazuhiko Tsuruya, Takanari Kitazono

    RENAL REPLACEMENT THERAPY   6 ( 1 )   2020.8

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    DOI: 10.1186/s41100-020-00289-6

  • Survival comparison between superficialization of the brachial artery and tunneled central venous catheter placement in hemodialysis patients with heart failure: A retrospective study

    Kaneyasu Nakagawa, Shunsuke Yamada, Yuta Matsukuma, Toshiaki Nakano, Koji Mitsuiki

    THERAPEUTIC APHERESIS AND DIALYSIS   24 ( 4 )   408 - 415   2020.8

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    DOI: 10.1111/1744-9987.13457

  • Prophylactic Oral Antibiotics for Postendoscopic Peritonitis in Peritoneal Dialysis

    Hideaki Oka, Kazuhiko Tsuruya, Toshiaki Nakano

    THERAPEUTIC APHERESIS AND DIALYSIS   24 ( 4 )   462 - 463   2020.8

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    DOI: 10.1111/1744-9987.13442

  • Higher Cholesterol Level Predicts Cardiovascular Event and Inversely Associates With Mortality in Hemodialysis Patients: 10-Year Outcomes of the Q-Cohort Study

    Toshiaki Nakano, Hiroto Hiyamuta, Ryusuke Yotsueda, Shigeru Tanaka, Masatomo Taniguchi, Kazuhiko Tsuruya, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   24 ( 4 )   431 - 438   2020.8

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    DOI: 10.1111/1744-9987.13455

  • Anti-glomerular basement membrane disease complicated with posterior reversible encephalopathy syndrome and subcortical cerebral hemorrhage: a case report and review of the literature

    Shoji Tsuneyoshi, Shunsuke Yamada, Hidenobu Matsumoto, Sahomi Yamaguchi, Kayo Wakisaka, Kana Ueki, Kiichiro Fujisaki, Tetsuro Ago, Toshiaki Nakano, Takanari Kitazono

    CEN CASE REPORTS   9 ( 3 )   278 - 284   2020.8

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    DOI: 10.1007/s13730-020-00473-x

  • Survival comparison between superficialization of the brachial artery and tunneled central venous catheter placement in hemodialysis patients with heart failure A retrospective study Reviewed

    Kaneyasu Nakagawa, Shunsuke Yamada, Yuta Matsukuma, Toshiaki Nakano, Koji Mitsuiki

    Therapeutic Apheresis and Dialysis   24 ( 4 )   408 - 415   2020.8

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    DOI: 10.1111/1744-9987.13457

  • Association of serum phosphate concentration with the incidence of intervention for peripheral artery disease in patients undergoing hemodialysis 10-year outcomes of the Q-Cohort Study Reviewed

    Sho Shimamoto, Shunsuke Yamada, Hiroto Hiyamuta, Hokuto Arase, Masatomo Taniguchi, Masanori Tokumoto, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Atherosclerosis   304   22 - 29   2020.7

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    DOI: 10.1016/j.atherosclerosis.2020.04.022

  • Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis (vol 27, pg 147, 2020)

    Takafumi Toyohara, Filip Roudnicky, Mary H. C. Florido, Toshiaki Nakano, Haojie Yu, Shunsuke Katsuki, Minjin Lee, Torsten Meissner, Max Friesen, Lance S. Davidow, Leon Ptaszek, Takaaki Abe, Lee L. Rubin, Alexandre C. Pereira, Masanori Aikawa, Chad A. Cowan

    CELL STEM CELL   27 ( 1 )   178 - 180   2020.7

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    DOI: 10.1016/j.stem.2020.05.013

  • Utility of Columbia classification in focal segmental glomerulosclerosis: renal prognosis and treatment response among the pathological variants

    Akihiro Tsuchimoto, Yuta Matsukuma, Kenji Ueki, Shigeru Tanaka, Kosuke Masutani, Kaneyasu Nakagawa, Koji Mitsuiki, Noriko Uesugi, Ritsuko Katafuchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    NEPHROLOGY DIALYSIS TRANSPLANTATION   35 ( 7 )   1219 - 1227   2020.7

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    DOI: 10.1093/ndt/gfy374

  • Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis

    Takafumi Toyohara, Filip Roudnicky, Mary H. C. Florido, Toshiaki Nakano, Haojie Yu, Shunsuke Katsuki, Minjin Lee, Torsten Meissner, Max Friesen, Lance S. Davidow, Leon Ptaszek, Takaaki Abe, Lee L. Rubin, Alexandre C. Pereira, Masanori Aikawa, Chad A. Cowan

    CELL STEM CELL   27 ( 1 )   147 - +   2020.7

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    DOI: 10.1016/j.stem.2020.04.018

  • Association of serum phosphate concentration with the incidence of intervention for peripheral artery disease in patients undergoing hemodialysis: 10-year outcomes of the Q-Cohort Study

    Sho Shimamoto, Shunsuke Yamada, Hiroto Hiyamuta, Hokuto Arase, Masatomo Taniguchi, Masanori Tokumoto, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    ATHEROSCLEROSIS   304   22 - 29   2020.7

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    DOI: 10.1016/j.atherosclerosis.2020.04.022

  • Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese - The Hisayama Study -

    Keisuke Yamasaki, Jun Hata, Yoshihiko Furuta, Naoki Hirabayashi, Tomoyuki Ohara, Daigo Yoshida, Yoichiro Hirakawa, Toshiaki Nakano, Takanari Kitazono, Toshiharu Ninomiya

    CIRCULATION JOURNAL   84 ( 7 )   1207 - 1207   2020.7

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    DOI: 10.1253/circj.CJ-66-0179

  • Association Between Plasma Intact Parathyroid Hormone Levels and the Prevalence of Atrial Fibrillation in Patients With Chronic Kidney Disease -The Fukuoka Kidney Disease Registry Study-

    Hokuto Arase, Shunsuke Yamada, Shigeru Tanaka, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    CIRCULATION JOURNAL   84 ( 7 )   1105 - +   2020.7

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    DOI: 10.1253/circj.CJ-19-1201

  • Utility of Columbia classification in focal segmental glomerulosclerosis renal prognosis and treatment response among the pathological variants Reviewed

    Akihiro Tsuchimoto, Yuta Matsukuma, Kenji Ueki, Shigeru Tanaka, Kosuke Masutani, Kaneyasu Nakagawa, Koji Mitsuiki, Noriko Uesugi, Ritsuko Katafuchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   35 ( 7 )   1219 - 1227   2020.7

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    DOI: 10.1093/ndt/gfy374

  • Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis Reviewed

    Takafumi Toyohara, Filip Roudnicky, Mary H.C. Florido, Toshiaki Nakano, Haojie Yu, Shunsuke Katsuki, Minjin Lee, Torsten Meissner, Max Friesen, Lance S. Davidow, Leon Ptaszek, Takaaki Abe, Lee L. Rubin, Alexandre C. Pereira, Masanori Aikawa, Chad A. Cowan

    Cell stem cell   27 ( 1 )   147 - 157.e7   2020.7

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    DOI: 10.1016/j.stem.2020.04.018

  • Association between plasma intact parathyroid hormone levels and the prevalence of atrial fibrillation in patients with chronic kidney disease The fukuoka kidney disease registry study Reviewed

    Hokuto Arase, Shunsuke Yamada, Shigeru Tanaka, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Circulation Journal   84 ( 7 )   1105 - 1111   2020.6

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    DOI: 10.1253/circj.CJ-19-1201

  • Late renal recovery after treatment over 1year post-onset in an atypical hemolytic uremic syndrome: a case report

    Yusuke Kuroki, Koji Mitsuiki, Kaneyasu Nakagawa, Kazuhiko Tsuruya, Ritsuko Katafuchi, Hideki Hirakata, Toshiaki Nakano

    BMC NEPHROLOGY   21 ( 1 )   2020.6

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    DOI: 10.1186/s12882-020-01897-4

  • Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese - The Hisayama Study -

    Keisuke Yamasaki, Jun Hata, Yoshihiko Furuta, Naoki Hirabayashi, Tomoyuki Ohara, Daigo Yoshida, Yoichiro Hirakawa, Toshiaki Nakano, Takanari Kitazono, Toshiharu Ninomiya

    CIRCULATION JOURNAL   84 ( 6 )   935 - +   2020.6

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    DOI: 10.1253/circj.CJ-19-1069

  • Late renal recovery after treatment over 1 year post-onset in an atypical hemolytic uremic syndrome a case report Reviewed

    21 ( 1 )   236   2020.6

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    BACKGROUND: Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disease that leads to end-stage kidney disease if only a poor response to plasma exchanges (PEs) or eculizumab therapy is achieved. CASE PRESENTATION: A 58-year-old Japanese man presented with thrombocytopenia, anemia, and kidney failure requiring dialysis without any underlying disease. A kidney biopsy revealed marked mesangiolysis in all glomeruli, compatible with thrombotic microangiopathy (TMA). Based on the positive anti- factor H antibody and negative result for secondary TMA, we diagnosed him as aHUS. Despite eculizumab administration after eight sessions of PE, neither platelet normalization nor kidney recovery was achieved. Eight months later, we discontinued eculizumab therapy due to anaphylactic reaction. At 15 months after the onset of TMA, his platelet count increased gradually from 40 to 150 × 103/μL with a decreased serum creatinine level and increased urine output, eventually allowing the withdrawal of dialysis therapy. A second kidney biopsy showed mesangial widening compatible with the healing of TMA. CONCLUSIONS: This case indicates that aHUS with PEs and eculizumab therapy has the potential for renal recovery even if over 1 year has passed.

    DOI: 10.1186/s12882-020-01897-4

  • Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease A cross-sectional study Reviewed

    Yui Arita, Masaru Nakayama, Yuta Matsukuma, Ryota Yoshitomi, Makiko Seki, Akiko Fukui, Susumu Tsuda, Yuri Sonoda, Rina Imazu, Kimika Arakawa, Mitsuhiro Tominaga, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    BMC Nephrology   21 ( 1 )   2020.5

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    DOI: 10.1186/s12882-020-01864-z

  • The glucose degradation product methylglyoxal induces immature angiogenesis in patients undergoing peritoneal dialysis

    Toshiaki Nakano, Torisu Kumiko, Tohru Mizumasa, Yusuke Kuroki, Kazuhiko Tsuruya, Takanari Kitazono

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   525 ( 3 )   767 - 772   2020.5

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    DOI: 10.1016/j.bbrc.2020.02.048

  • Brachiocephalic vein compression caused by a mediastinal cystic tumor presenting with rapidly progressive upper limb swelling and pain in a patient on hemodialysis with a newly created arteriovenous graft

    Sahomi Yamaguchi, Shunsuke Yamada, Manako Takesako, Toshiaki Nakano, Takanari Kitazono

    CEN CASE REPORTS   9 ( 2 )   186 - 187   2020.5

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    DOI: 10.1007/s13730-019-00433-0

  • Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease: a cross-sectional study

    Yui Arita, Masaru Nakayama, Yuta Matsukuma, Ryota Yoshitomi, Makiko Seki, Akiko Fukui, Susumu Tsuda, Yuri Sonoda, Rina Imazu, Kimika Arakawa, Mitsuhiro Tominaga, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    BMC NEPHROLOGY   21 ( 1 )   2020.5

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    DOI: 10.1186/s12882-020-01864-z

  • Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients Reviewed

    Hiroaki Tsujikawa, Shigeru Tanaka, Masatoshi Hara, Yasuhiro Kawai, Yuta Matsukuma, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   24 ( 2 )   202 - 207   2020.4

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    DOI: 10.1111/1744-9987.12865

  • Increased Risk of Infection-Related and All-Cause Death in Hypercalcemic Patients Receiving Hemodialysis: The Q-Cohort Study

    Shunsuke Yamada, Hokuto Arase, Masanori Tokumoto, Masatomo Taniguchi, Hisako Yoshida, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    SCIENTIFIC REPORTS   10 ( 1 )   2020.4

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    DOI: 10.1038/s41598-020-63334-8

  • Geriatric Nutritional Risk Index (GNRI) and Creatinine Index Equally Predict the Risk of Mortality in Hemodialysis Patients: J-DOPPS

    Shunsuke Yamada, Shungo Yamamoto, Shingo Fukuma, Toshiaki Nakano, Kazuhiko Tsuruya, Masaaki Inaba

    SCIENTIFIC REPORTS   10 ( 1 )   2020.4

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    DOI: 10.1038/s41598-020-62720-6

  • Effect of renin-angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan

    Akihiro Tsuchimoto, Kosuke Masutani, Kenji Ueki, Kaneyasu Nakagawa, Yuta Matsukuma, Shigeru Tanaka, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Hiroshi Noguchi, Keizo Kaku, Yasuhiro Okabe, Toshiaki Nakano, Takanari Kitazono, Masafumi Nakamura, Hideki Ishida, Kazunari Tanabe

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   24 ( 4 )   369 - 378   2020.4

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    DOI: 10.1007/s10157-019-01827-1

  • Case of Chronic Cough Caused by Accidental Inhalation of Lanthanum Carbonate Granules

    Hideaki Oka, Satoru Shichijo, Toshiaki Nakano

    THERAPEUTIC APHERESIS AND DIALYSIS   24 ( 2 )   235 - 236   2020.4

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    DOI: 10.1111/1744-9987.13396

  • Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients

    Hiroaki Tsujikawa, Shigeru Tanaka, Masatoshi Hara, Yasuhiro Kawai, Yuta Matsukuma, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   24 ( 2 )   202 - 207   2020.4

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    DOI: 10.1111/1744-9987.12865

  • Effect of renin–angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients retrospective multicenter study in Japan Reviewed

    24 ( 4 )   369 - 378   2020.4

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    Background: Renin–angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. Method: We investigated 900 kidney transplant patients in a multicenter retrospective cohort study in Japan and compared death-censored graft survival and CVE (total, cardiac events, stroke) based on RASB use within 12 months after KT. The associations were examined using a Cox hazard model and propensity score-matching analysis. Results: The cohort comprised 375 patients treated with RASBs (RASB group) and 525 patients without RASBs (control group). The median observational period was 82 months, with 68 patients reaching graft loss: 79 total CVE, 36 cardiac events, 26 stroke. In a matching cohort comprising 582 patients, death-censored graft survival, total CVE, and cardiac events were not different between the two groups. Only stroke incidence rate was significantly lower in the RASB group compared with the control group (1.4 vs. 6.4 per 1000 patients/year, log-ranked P = 0.005). In a multivariable analysis, stroke events were also significantly lower in the RASB group compared with the control group (Hazard ratio and 95% confidence interval, 0.20 [0.04–0.62]). Conclusion: Thus, RASBs potentially reduce stroke events in KT recipients.

    DOI: 10.1007/s10157-019-01827-1

  • The glucose degradation product methylglyoxal induces immature angiogenesis in patients undergoing peritoneal dialysis. Reviewed International journal

    Nakano T, Kumiko T, Mizumasa T, Kuroki Y, Tsuruya K, Kitazono T.

    Biochem Biophys Res Commun. 2020 Mar 5. pii: S0006-291X(20)30316-8.   2020.3

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  • Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis A Placebo-Controlled, Double-Blind, Crossover Study Reviewed

    Seishi Aihara, Shunsuke Yamada, Satoru Shichijo, Kento Fukumitsu, Mika Kondo, Yutaro Hirashima, Hideaki Oka, Taro Kamimura, Atsumi Harada, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   24 ( 1 )   34 - 41   2020.2

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    DOI: 10.1111/1744-9987.12813

  • Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms

    Masataka Tsuda, Kaito Kitamasu, Seiji Hosokawa, Toshiaki Nakano, Hiroshi Ide

    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS   39 ( 1-3 )   170 - 184   2020.2

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    DOI: 10.1080/15257770.2019.1674332

  • Rapid formation of large pseudostones and acute cholangitis caused by ceftriaxone treatment for bacterial pneumonia in a patient on kidney transplantation: potential risk of ceftriaxone use in patients with decreased kidney function

    Shunsuke Yamada, Manako Takesako, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CEN CASE REPORTS   9 ( 1 )   87 - 88   2020.2

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    DOI: 10.1007/s13730-019-00418-z

  • Lower Serum Albumin Level Is Associated With an Increased Risk for Loss of Residual Kidney Function in Patients Receiving Peritoneal Dialysis

    Shunsuke Yamada, Yasuhiro Kawai, Shoji Tsuneyoshi, Hiroaki Tsujikawa, Hokuto Arase, Hisako Yoshida, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   24 ( 1 )   72 - 80   2020.2

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    DOI: 10.1111/1744-9987.12861

  • Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo-Controlled, Double-Blind, Crossover Study

    Seishi Aihara, Shunsuke Yamada, Satoru Shichijo, Kento Fukumitsu, Mika Kondo, Yutaro Hirashima, Hideaki Oka, Taro Kamimura, Atsumi Harada, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   24 ( 1 )   34 - 41   2020.2

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    DOI: 10.1111/1744-9987.12813

  • Hypocomplementemic urticarial vasculitis syndrome with gastrointestinal vasculitis and crescentic membranoproliferative glomerulonephritis without immune complex deposits

    Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Kumiko Torisu, Kiichiro Fujisaki, Takehiro Torisu, Yuichi Yamada, Yoshinao Oda, Kosuke Masutani, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CEN CASE REPORTS   9 ( 1 )   30 - 35   2020.2

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    DOI: 10.1007/s13730-019-00421-4

  • Axillary arterial angiosarcoma in a nonfunctioning arteriovenous fistula limb of a patient undergoing hemodialysis: case report with literature review

    Seishi Aihara, Shunichi Saito, Hideaki Oka, Taro Kamimura, Terutoshi Yamaoka, Kotaro Kajiwara, Toshiaki Nakano, Takanari Kitazono

    CEN CASE REPORTS   9 ( 1 )   36 - 41   2020.2

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    DOI: 10.1007/s13730-019-00422-3

  • A case of ischemic osteopathy in a hemodialysis patient with advanced peripheral artery disease

    Shunsuke Yamada, Toshiaki Nakano, Hiromasa Kitamura, Takanari Kitazono

    CEN CASE REPORTS   9 ( 1 )   89 - 90   2020.2

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    DOI: 10.1007/s13730-019-00425-0

  • Lower Serum Albumin Level Is Associated With an Increased Risk for Loss of Residual Kidney Function in Patients Receiving Peritoneal Dialysis Reviewed

    Shunsuke Yamada, Yasuhiro Kawai, Shoji Tsuneyoshi, Hiroaki Tsujikawa, Hokuto Arase, Hisako Yoshida, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   24 ( 1 )   72 - 80   2020.2

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    DOI: 10.1111/1744-9987.12861

  • Advanced glycation end products are associated with immature angiogenesis and peritoneal dysfunction in patients on peritoneal dialysis. Reviewed International journal

    Nakano T, Mizumasa T, Kuroki Y, Eriguchi M, Yoshida H, Tanigichi M, Masutani K, Tsuruya K, Kitazono T.

    Perit Dial Int. 2020 Jan;40(1):67-75.   2020.1

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  • Modified creatinine index and risk for long-term infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-Cohort Study

    Hokuto Arase, Shunsuke Yamada, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    SCIENTIFIC REPORTS   10 ( 1 )   2020.1

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    DOI: 10.1038/s41598-020-58181-6

  • Advanced glycation end products are associated with immature angiogenesis and peritoneal dysfunction in patients on peritoneal dialysis

    Toshiaki Nakano, Tohru Mizumasa, Yusuke Kuroki, Masahiro Eriguchi, Hisako Yoshida, Masatomo Taniguchi, Kosuke Masutani, Kazuhiko Tsuruya, Takanari Kitazono

    PERITONEAL DIALYSIS INTERNATIONAL   40 ( 1 )   67 - 75   2020.1

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    DOI: 10.1177/0896860819878344

  • Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease the Fukuoka kidney disease registry study Reviewed

    Akiko Fukui, Masaru Nakayama, Shigeru Tanaka, Yuta Matsukuma, Ryota Yoshitomi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Clinical and Experimental Nephrology   2020

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    DOI: 10.1007/s10157-020-01950-4

  • The incidence and associated factors of sudden death in patients on hemodialysis 10-year outcome of the Q-cohort study Reviewed

    Hiroto Hiyamuta, Shigeru Tanaka, Masatomo Taniguchi, Masanori Tokumoto, Kiichiro Fujisaki, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Journal of atherosclerosis and thrombosis   27 ( 4 )   306 - 318   2020

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    DOI: 10.5551/jat.49833

  • The association between dialysis dose and risk of cancer death in patients undergoing hemodialysis The Q-cohort study Reviewed

    Masatoshi Hara, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Internal Medicine   59 ( 9 )   1141 - 1148   2020

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    DOI: 10.2169/internalmedicine.4027-19

  • Significance of revised criteria for chronic active T cell–mediated rejection in the 2017 Banff classification Surveillance by 1-year protocol biopsies for kidney transplantation Reviewed

    2020

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    Diagnostic criteria for chronic active T cell–mediated rejection (CA-TCMR) were revised in the Banff 2017 consensus, but it is unknown whether the new criteria predict graft prognosis of kidney transplantation. We enrolled 406 kidney allograft recipients who underwent a 1-year protocol biopsy (PB) and investigated the diagnostic significance of Banff 2017. Interobserver reproducibility of the 3 diagnosticians showed a substantial agreement rate of 0.68 in Fleiss's kappa coefficient. Thirty-three patients (8%) were classified as CA-TCMR according to Banff 2017, and 6 were previously diagnosed as normal, 12 as acute TCMR, 10 with borderline changes, and 5 as CA-TCMR according to Banff 2015 criteria. Determinant factors of CA-TCMR were cyclosporine use (vs tacrolimus), previous acute rejection, and BK polyomavirus-associated nephropathy. In survival analysis, the new diagnosis of CA-TCMR predicted a composite graft endpoint defined as doubling serum creatinine or death-censored graft loss (log-rank test, P <.001). In multivariate analysis, CA-TCMR was associated with the second highest risk of the composite endpoint (hazard ratio: 5.42; 95% confidence interval, 2.02-14.61; P <.001 vs normal) behind antibody-mediated rejection. In conclusion, diagnosis of CA-TCMR in Banff 2017 may facilitate detecting an unfavorable prognosis of kidney allograft recipients who undergo a 1-year PB.

    DOI: 10.1111/ajt.16093

  • High low-density lipoprotein cholesterol as an independent risk factor for coronary restenosis in hemodialysis patients undergoing percutaneous coronary interventions Reviewed

    Shoko Hasegawa, Toshiaki Nakano, Yasushi Mukai, Yuta Matsukuma, Ryusuke Yotsueda, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kazuhiko Tsuruya, Hiroyuki Tsutsui, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   2020

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    DOI: 10.1111/1744-9987.13558

  • CORRIGENDUM Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese - The Hisayama Study Reviewed

    84 ( 7 )   1207   2020

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    DOI: 10.1253/circj.CJ-66-0179

  • Association of normalized protein catabolic rate (nPCR) with the risk of bone fracture in patients undergoing maintenance hemodialysis The Q-Cohort Study Reviewed

    Shotaro Ohnaka, Shunsuke Yamada, Hiroaki Tsujikawa, Hokuto Arase, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Clinical Nutrition   2020

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    DOI: 10.1016/j.clnu.2020.07.003

  • Association of albuminuria with white matter hyperintensities volume on brain magnetic resonance imaging in elderly Japanese ― the Hisayama study ― Reviewed

    84 ( 6 )   935 - 942   2020

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    Background: Both chronic kidney disease and brain white matter hyperintensities (WMH) are known to be risk factors of dementia and mortality. Methods and Results: In 2012, 1,214 community-dwelling Japanese subjects aged ≥65 years underwent brain magnetic resonance imaging (MRI) scans and a comprehensive health examination. This study investigated associations of the urinary albumin: creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) with the WMH volume to intracranial volume (WMHV: ICV) ratio, and the association of the combination of UACR and the WMHV: ICV ratio with cognitive decline and mortality risk. The geometric mean of the WMHV: ICV ratio was 0.223% in the entire study population, and increased significantly with higher UACR levels after adjusting for potential confounding factors (0.213% for normoalbuminuria, 0.248% for microalbuminuria, and 0.332% for macroalbuminuria; Ptrend=0.01). In contrast, there was no clear association between eGFR and the WMHV: ICV ratio. Compared with subjects with normoalbuminuria and a smaller WMHV: ICV ratio (<0.257% [median]), subjects with albuminuria and a larger WMHV: ICV ratio (≥0.257%) had higher probabilities of cognitive decline at baseline and all-cause death during the follow-up. Conclusions: This study suggests that subjects with albuminuria have a greater risk of WMH enlargement and that the combination of albuminuria and WMH enlargement increases the risk of cognitive decline and all-cause mortality in an elderly Japanese population.

    DOI: 10.1253/circj.CJ-19-1069

  • Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients Ten-Year Outcomes of the Q-Cohort Study Reviewed

    Shigeru Tanaka, Toshiharu Ninomiya, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kosuke Masutani, Hiroaki Ooboshi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Scientific reports   9 ( 1 )   2019.12

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    DOI: 10.1038/s41598-018-37961-1

  • Higher Cholesterol Level Predicts Cardiovascular Event and Inversely Associates With Mortality in Hemodialysis Patients: 10-Year Outcomes of the Q-Cohort Study. Invited Reviewed International journal

    Nakano T, Hiyamuta H, Yotsueda R, Tanaka S, Taniguchi M, Tsuruya K, Kitazono T.

    Ther Apher Dial. 2019 Nov 8.   2019.11

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  • Development and validation of a new prediction model for graft function using preoperative marginal factors in living-donor kidney transplantation

    Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Toshiaki Nakano, Yasuhiro Okabe, Yoichi Kakuta, Masayoshi Okumi, Kazuhiko Tsuruya, Masafumi Nakamura, Takanari Kitazono, Kazunari Tanabe, Hideki Ishida, Masashi Inui, Daisuke Toki, Kohei Unagami, Miyuki Furusawa, Makiko Fujiwara, Kayo Kusubayashi, Katsunori Shimada

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 ( 11 )   1331 - 1340   2019.11

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    DOI: 10.1007/s10157-019-01774-x

  • Development and validation of a new prediction model for graft function using preoperative marginal factors in living-donor kidney transplantation Reviewed

    , Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Toshiaki Nakano, Yasuhiro Okabe, Yoichi Kakuta, Masayoshi Okumi, Kazuhiko Tsuruya, Masafumi Nakamura, Takanari Kitazono, Kazunari Tanabe

    Clinical and Experimental Nephrology   23 ( 11 )   1331 - 1340   2019.11

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    DOI: 10.1007/s10157-019-01774-x

  • Reduced Estimated GFR and Cardiac Remodeling A Population-Based Autopsy Study Reviewed

    Kensuke Izumaru, Jun Hata, Toshiaki Nakano, Yutaka Nakashima, Masaharu Nagata, Masayo Fukuhara, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    American Journal of Kidney Diseases   74 ( 3 )   373 - 381   2019.9

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    DOI: 10.1053/j.ajkd.2019.02.013

  • Short- and Long-term Effects of Dialysate Calcium Concentrations on Mineral and Bone Metabolism in Hemodialysis Patients: The K4 Study

    Teppei Sakoh, Masatomo Taniguchi, Shunsuke Yamada, Shotaro Ohnaka, Hokuto Arase, Masanori Tokumoto, Taihei Yanagida, Koji Mitsuiki, Hideki Hirakata, Toshiaki Nakano, Takanari Kitazono, Kazuhiko Tsuruya

    KIDNEY MEDICINE   1 ( 5 )   296 - 306   2019.9

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    DOI: 10.1016/j.xkme.2019.08.002

  • Relative hypophosphatemia early after transplantation is a predictor of good kidney graft function

    Kentaro Nakai, Koji Mitsuiki, Yusuke Kuroki, Takehiro Nishiki, Kentaro Motoyama, Toshiaki Nakano, Takanari Kitazono

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 ( 9 )   1161 - 1168   2019.9

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    DOI: 10.1007/s10157-019-01756-z

  • Reduced Estimated GFR and Cardiac Remodeling: A Population-based Autopsy Study

    Kensuke Izumaru, Jun Hata, Toshiaki Nakano, Yutaka Nakashima, Masaharu Nagata, Masayo Fukuhara, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    AMERICAN JOURNAL OF KIDNEY DISEASES   74 ( 3 )   373 - 381   2019.9

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    DOI: 10.1053/j.ajkd.2019.02.013

  • Short- and Long-term Effects of Dialysate Calcium Concentrations on Mineral and Bone Metabolism in Hemodialysis Patients The K4 Study Reviewed

    Teppei Sakoh, Masatomo Taniguchi, Shunsuke Yamada, Shotaro Ohnaka, Hokuto Arase, Masanori Tokumoto, Taihei Yanagida, Koji Mitsuiki, Hideki Hirakata, Toshiaki Nakano, Takanari Kitazono, Kazuhiko Tsuruya

    Kidney Medicine   1 ( 5 )   296 - 306   2019.9

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    DOI: 10.1016/j.xkme.2019.08.002

  • Relative hypophosphatemia early after transplantation is a predictor of good kidney graft function Reviewed

    Kentaro Nakai, Koji Mitsuiki, Yusuke Kuroki, Takehiro Nishiki, Kentaro Motoyama, Toshiaki Nakano, Takanari Kitazono

    Clinical and Experimental Nephrology   23 ( 9 )   1161 - 1168   2019.9

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    DOI: 10.1007/s10157-019-01756-z

  • Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus–associated Nephropathy Reviewed

    51 ( 5 )   1410 - 1414   2019.6

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    Background: Graft biopsy is the gold standard for diagnosis of BK polyomavirus–associated nephropathy (BKPyVAN), and polymerase chain reaction is the most specific screening technique. Development of a noninvasive, cost-effective marker for BKPyVAN is important. Methods: We reviewed 492 adult kidney transplant patients. We investigated peripheral blood lymphocyte (PBL)count and urinary cytology at graft biopsy in patients with BKVPyAN (n = 21), acute T-cell–mediated rejection (n = 79), and no evidence of acute rejection (n = 149). We performed univariate and multivariate logistic regression and receiver operating characteristics analyses to compare the test performance of PBL count, urinary cytology, and their combination for diagnosis of BKPyVAN. Results: The PBL count at biopsy was significantly lower in the BKPyVAN group than the acute T-cell–mediated rejection and no acute rejection groups (959 ± 290/μL, 1433 ± 673/μL, and 1531 ± 549/μL, respectively; P <.01). The PBL count was 959 ± 290/μL at diagnosis of BKPyVAN and increased to 1123 ± 377/μL, 1238 ± 419/μL, and 1292 ± 491/μL at 1, 2, and 3 months after treatment, respectively (P <.05). On univariate analysis, the area under the curve was significantly higher for the combined model than for PBL and cytology alone (0.930, 0.797, and 0.875, respectively; P <.01). The improved test performance in the combined model remained significant after multivariate adjustment (0.972, 0.844, and 0.928, respectively; P <.01). Conclusions: Decreased PBL count was found in BKPyVAN, and the predictive performance of the combination of PBL count and urinary cytology was significantly enhanced for diagnosis of BKPyVAN.

    DOI: 10.1016/j.transproceed.2019.01.129

  • Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus-associated Nephropathy

    Kosuke Masutani, Akihiro Tsuchimoto, Yuta Matsukuma, Shigeru Tanaka, Keizo Kaku, Hiroshi Noguchi, Kei Kurihara, Yasuhiro Okabe, Toshiaki Nakano, Kazuhiko Tsuruya, Hitoshi Nakashima, Masafumi Nakamura, Takanari Kitazono

    TRANSPLANTATION PROCEEDINGS   51 ( 5 )   1410 - 1414   2019.6

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    DOI: 10.1016/j.transproceed.2019.01.129

  • Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease

    Shunsuke Yamada, Hokuto Arase, Toshifumi Morishita, Akihiro Tsuchimoto, Kumiko Torisu, Takehiro Torisu, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    CEN CASE REPORTS   8 ( 2 )   83 - 88   2019.5

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    DOI: 10.1007/s13730-018-0371-9

  • Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis-Related Peritonitis Reviewed

    Hideaki Oka, Shunsuke Yamada, Taro Kamimura, Seishi Aihara, Masahide Hyodo, Nagaaki Terakado, Atsumi Harada, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   23 ( 2 )   187 - 194   2019.4

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    DOI: 10.1111/1744-9987.12757

  • Kidney transplantation for treatment of end-stage kidney disease after haematopoietic stem cell transplantation: case series and literature review

    Akihiro Tsuchimoto, Kosuke Masutani, Kazuya Omoto, Masayoshi Okumi, Yasuhiro Okabe, Takehiro Nishiki, Morihito Ota, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono, Masafumi Nakamura, Hideki Ishida, Kazunari Tanabe, Kazunari Tanabe, Hideki Ishida, Masashi Inui, Kazuya Omoto, Tomokazu Shimizu, Masayoshi Okumi, Toshihito Hirai, Daisuke Toki, Kohei Unagami, Hiroshi Toma, Hiroki Shirakawa, Yasuhiro Okabe, Atsuchi Doi, Keizo Kaku, Kei Kurihara, Ota Morihito, Katsunori Shimada, Masayoshi Okumi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 ( 4 )   561 - 568   2019.4

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    DOI: 10.1007/s10157-018-1672-1

  • Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study

    Makiko Seki, Masaru Nakayama, Teppei Sakoh, Ryota Yoshitomi, Akiko Fukui, Eisuke Katafuchi, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    BMC NEPHROLOGY   20   2019.4

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    DOI: 10.1186/s12882-019-1306-1

  • Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis-Related Peritonitis

    Hideaki Oka, Shunsuke Yamada, Taro Kamimura, Seishi Aihara, Masahide Hyodo, Nagaaki Terakado, Atsumi Harada, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   23 ( 2 )   187 - 194   2019.4

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    DOI: 10.1111/1744-9987.12757

  • Kidney transplantation for treatment of end-stage kidney disease after haematopoietic stem cell transplantation case series and literature review Reviewed

    , Akihiro Tsuchimoto, Kosuke Masutani, Kazuya Omoto, Masayoshi Okumi, Yasuhiro Okabe, Takehiro Nishiki, Morihito Ota, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono, Masafumi Nakamura, Hideki Ishida, Kazunari Tanabe, Kazunari Tanabe, Masashi Inui, Tomokazu Shimizu, Toshihito Hirai, Daisuke Toki, Kohei Unagami, Hiroshi Toma, Hiroki Shirakawa, Atsuchi Doi, Keizo Kaku, Kei Kurihara, Ota Morihito

    Clinical and Experimental Nephrology   23 ( 4 )   561 - 568   2019.4

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    DOI: 10.1007/s10157-018-1672-1

  • Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease A prospective observational study Reviewed

    Makiko Seki, Masaru Nakayama, Teppei Sakoh, Ryota Yoshitomi, Akiko Fukui, Eisuke Katafuchi, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    BMC Nephrology   20 ( 1 )   2019.4

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    DOI: 10.1186/s12882-019-1306-1

  • Development of a risk prediction model for infection-related mortality in patients undergoing peritoneal dialysis Reviewed

    Hiroaki Tsujikawa, Shigeru Tanaka, Yuta Matsukuma, Hidetoshi Kanai, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    PloS one   14 ( 3 )   2019.3

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    DOI: 10.1371/journal.pone.0213922

  • Early postoperative change in serum creatinine predicts acute kidney injury after cardiothoracic surgery: a retrospective cohort study

    Hideaki Oka, Shunsuke Yamada, Taro Kamimura, Atsumi Harada, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 ( 3 )   325 - 334   2019.3

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    DOI: 10.1007/s10157-018-1638-3

  • Development of a risk prediction model for infection-related mortality in patients undergoing peritoneal dialysis

    Hiroaki Tsujikawa, Shigeru Tanaka, Yuta Matsukuma, Hidetoshi Kanai, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    PLOS ONE   14 ( 3 )   2019.3

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    DOI: 10.1371/journal.pone.0213922

  • Author's reply to the letter to the editor regarding "Use of early postoperative serum creatinine changes to predict acute kidney injury after cardiothoracic surgery"

    Hideaki Oka, Shunsuke Yamada, Toshiaki Nakano

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 ( 3 )   433 - 434   2019.3

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    DOI: 10.1007/s10157-018-1671-2

  • Early postoperative change in serum creatinine predicts acute kidney injury after cardiothoracic surgery a retrospective cohort study Reviewed

    Hideaki Oka, Shunsuke Yamada, Taro Kamimura, Atsumi Harada, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Clinical and Experimental Nephrology   23 ( 3 )   325 - 334   2019.3

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    DOI: 10.1007/s10157-018-1638-3

  • Association of geriatric nutritional risk index with infection-related mortality in patients undergoing hemodialysis The Q-Cohort Study Reviewed

    Yuta Matsukuma, Shigeru Tanaka, Masatomo Taniguchi, Toshiaki Nakano, Kosuke Masutani, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya

    Clinical Nutrition   38 ( 1 )   279 - 287   2019.2

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    DOI: 10.1016/j.clnu.2018.01.019

  • Thrombotic microangiopathy associated with anticardiolipin antibody in a kidney transplant recipient with polycythemia

    Akihiro Tsuchimoto, Yuta Matsukuma, Kenji Ueki, Takehiro Nishiki, Atsushi Doi, Yasuhiro Okabe, Masafumi Nakamura, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono, Kosuke Masutani

    CEN CASE REPORTS   8 ( 1 )   1 - 7   2019.2

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    DOI: 10.1007/s13730-018-0354-x

  • Association of geriatric nutritional risk index with infection-related mortality in patients undergoing hemodialysis: The Q-Cohort Study

    Yuta Matsukuma, Shigeru Tanaka, Masatomo Taniguchi, Toshiaki Nakano, Kosuke Masutani, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya

    CLINICAL NUTRITION   38 ( 1 )   279 - 287   2019.2

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    DOI: 10.1016/j.clnu.2018.01.019

  • High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease Reviewed

    Ryota Yoshitomi, Masaru Nakayama, Teppei Sakoh, Akiko Fukui, Eisuke Katafuchi, Makiko Seki, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Renal failure   41 ( 1 )   238 - 243   2019.1

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    DOI: 10.1080/0886022X.2019.1595645

  • Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling Potential Mechanism for Accelerated Atherogenesis in Chronic Kidney Disease

    Toshiaki Nakano, Shunsuke Katsuki, Mingxian Chen, Julius L. Decano, Arda Halu, Lang Ho Lee, Diego V. S. Pestana, Angelo S. T. Kum, Rodrigo K. Kuromoto, Whitney S. Golden, Mario S. Boff, Gabriel C. Guimaraes, Hideyuki Higashi, Kevin J. Kauffman, Takashi Maejima, Takehiro Suzuki, Hiroshi Iwata, Albert-Laszlo Barabasi, Jon C. Aster, Daniel G. Anderson, Amitabh Sharma, Sasha A. Singh, Elena Aikawa, Masanori Aikawa

    CIRCULATION   139 ( 1 )   78 - 96   2019.1

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    DOI: 10.1161/CIRCULATIONAHA.118.034588

  • Hypercalcemia and acute kidney injury induced by eldecalcitol in patients with osteoporosis: a case series of 32 patients at a single facility

    Seishi Aihara, Shunsuke Yamada, Hideaki Oka, Taro Kamimura, Toshiaki Nakano, Kazuhiko Tsuruya, Atsumi Harada

    RENAL FAILURE   41 ( 1 )   88 - 97   2019.1

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    DOI: 10.1080/0886022X.2019.1578667

  • High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease

    Ryota Yoshitomi, Masaru Nakayama, Teppei Sakoh, Akiko Fukui, Eisuke Katafuchi, Makiko Seki, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    RENAL FAILURE   41 ( 1 )   238 - 243   2019.1

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    DOI: 10.1080/0886022X.2019.1595645

  • Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study

    Shigeru Tanaka, Toshiharu Ninomiya, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kosuke Masutani, Hiroaki Ooboshi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    SCIENTIFIC REPORTS   9   2019.1

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    DOI: 10.1038/s41598-018-37961-1

  • Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients The Q-Cohort Study Reviewed

    Masatoshi Hara, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Medicine (United States)   97 ( 51 )   2018.12

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    DOI: 10.1097/MD.0000000000013485

  • Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients The Q-Cohort Study

    Masatoshi Hara, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    MEDICINE   97 ( 51 )   2018.12

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    DOI: 10.1097/MD.0000000000013485

  • A case of congenital left ventricular diverticulum in a patient with autosomal dominant polycystic kidney disease: possible mechanistic link between polycystin and ventricular diverticulum

    Seishi Aihara, Shunsuke Yamada, Hidenori Matsusaka, Rami Tashiro, Hideaki Oka, Taro Kamimura, Atsumi Harada, Toshiaki Nakano, Takanari Kitazono, Kazuhiko Tsuruya

    CEN CASE REPORTS   7 ( 2 )   237 - 242   2018.11

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    DOI: 10.1007/s13730-018-0335-0

  • Diabetic Milieu Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification

    Ryo Kawakami, Shunsuke Katsuki, Julio F. Marchini, Richard Travers, Shinsuke Itoh, Toshiaki Nakano, Peter Libby, Masanori Aikawa, Kevin Croce, Elena Aikawa

    CIRCULATION   138   2018.11

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  • Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation and Vein Graft Lesion Development in LDL Receptor-Independent Mechanisms

    Shunsuke Katsuki, Toshiaki Nakano, Julius L. Decano, Hengmin Zhang, Gabriel Guimaraes, Maximillian A. Rogers, Whitney S. Golden, Ryo Kawakami, Charles K. Ozaki, Elena Aikawa, Masanori Aikawa

    CIRCULATION   138   2018.11

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  • Immobilization-induced severe hypercalcaemia successfully treated with reduced dose of zoledronate in a maintenance haemodialysis patient

    Shunsuke Yamada, Hokuto Arase, Sayaka Tachibana, Keigo Tomita, Masahiro Eriguchi, Kiichiro Fujisaki, Yasuhiro Okabe, Masafumi Nakamura, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    NEPHROLOGY   23 ( 10 )   963 - 964   2018.10

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    DOI: 10.1111/nep.13246

  • Modified creatinine index and risk for cardiovascular events and all-cause mortality in patients undergoing hemodialysis The Q-Cohort study Reviewed

    Hokuto Arase, Shunsuke Yamada, Ryusuke Yotsueda, Masatomo Taniguchi, Hisako Yoshida, Masanori Tokumoto, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Atherosclerosis   275   115 - 123   2018.8

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    DOI: 10.1016/j.atherosclerosis.2018.06.001

  • Modified creatinine index and risk for cardiovascular events and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort study

    Hokuto Arase, Shunsuke Yamada, Ryusuke Yotsueda, Masatomo Taniguchi, Hisako Yoshida, Masanori Tokumoto, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    ATHEROSCLEROSIS   275   115 - 123   2018.8

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    DOI: 10.1016/j.atherosclerosis.2018.06.001

  • Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction Reviewed

    Shoko Hasegawa, Toshiaki Nakano, Kumiko Torisu, Akihiro Tsuchimoto, Masahiro Eriguchi, Naoki Haruyama, Kosuke Masutani, Kazuhiko Tsuruya, Takanari Kitazono

    Laboratory Investigation   97 ( 12 )   1439 - 1452   2017.12

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    DOI: 10.1038/labinvest.2017.77

  • Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction

    Shoko Hasegawa, Toshiaki Nakano, Kumiko Torisu, Akihiro Tsuchimoto, Masahiro Eriguchi, Naoki Haruyama, Kosuke Masutani, Kazuhiko Tsuruya, Takanari Kitazono

    LABORATORY INVESTIGATION   97 ( 12 )   1439 - 1452   2017.12

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    DOI: 10.1038/labinvest.2017.77

  • The potential role of perivascular lymphatic vessels in preservation of kidney allograft function Reviewed

    Akihiro Tsuchimoto, Toshiaki Nakano, Shoko Hasegawa, Kosuke Masutani, Yuta Matsukuma, Masahiro Eriguchi, Masaharu Nagata, Takehiro Nishiki, Hidehisa Kitada, Masao Tanaka, Takanari Kitazono, Kazuhiko Tsuruya

    Clinical and Experimental Nephrology   21 ( 4 )   721 - 731   2017.8

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    DOI: 10.1007/s10157-016-1338-9

  • The potential role of perivascular lymphatic vessels in preservation of kidney allograft function

    Akihiro Tsuchimoto, Toshiaki Nakano, Shoko Hasegawa, Kosuke Masutani, Yuta Matsukuma, Masahiro Eriguchi, Masaharu Nagata, Takehiro Nishiki, Hidehisa Kitada, Masao Tanaka, Takanari Kitazono, Kazuhiko Tsuruya

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   21 ( 4 )   721 - 731   2017.8

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    DOI: 10.1007/s10157-016-1338-9

  • Delta-Like Ligand 4-Notch Signaling in Macrophage Activation

    Toshiaki Nakano, Daiju Fukuda, Jun-ichiro Koga, Masanori Aikawa

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   36 ( 10 )   2038 - 2047   2016.10

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    DOI: 10.1161/ATVBAHA.116.306926

  • Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure. Invited Reviewed International journal

    Koga JI*, Nakano T*, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M.

    Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2343-2353.   2015.11

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  • New-onset systemic lupus erythematosus in a long-term hemodialysis patient with acute pleuritis and pneumonitis

    Hiroto Hiyamuta, Shunsuke Yamada, Ryusuke Yotsueda, Shoko Hasegawa, Toshiaki Nakano, Masatomo Taniguchi, Hiroshi Tsukamoto, Takanari Kitazono, Kazuhiko Tsuruya

    CEN CASE REPORTS   4 ( 2 )   139 - 144   2015.11

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    DOI: 10.1007/s13730-014-0155-9

  • Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development Implications for the Treatment of Vein Graft Failure

    Jun-ichiro Koga, Toshiaki Nakano, James E. Dahlman, Jose-Luiz Figueiredo, Hengmin Zhang, Julius Decano, Omar F. Khan, Tomiharu Niida, Hiroshi Iwata, Jon C. Aster, Hideo Yagita, Daniel G. Anderson, C. Keith Ozaki, Masanori Aikawa

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   35 ( 11 )   2343 - 2353   2015.11

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    DOI: 10.1161/ATVBAHA.115.305516

  • Fibroblast Growth Factor 23, but not Parathyroid Hormone, Is Associated With Urinary Phosphate Regulation in Patients on Peritoneal Dialysis Reviewed

    Shunsuke Yamada, Kazuhiko Tsuruya, Masanori Tokumoto, Hisako Yoshida, Shoko Hasegawa, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Kosuke Masutani, Hiroaki Ooboshi, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   19 ( 1 )   73 - 80   2015.2

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    DOI: 10.1111/1744-9987.12221

  • Fibroblast Growth Factor 23, but not Parathyroid Hormone, Is Associated With Urinary Phosphate Regulation in Patients on Peritoneal Dialysis

    Shunsuke Yamada, Kazuhiko Tsuruya, Masanori Tokumoto, Hisako Yoshida, Shoko Hasegawa, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Kosuke Masutani, Hiroaki Ooboshi, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   19 ( 1 )   73 - 80   2015.2

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    DOI: 10.1111/1744-9987.12221

  • Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension Reviewed

    , Kiichiro Fujisaki, Kazuhiko Tsuruya, Toshiaki Nakano, Masatomo Taniguchi, Harumichi Higashi, Ritsuko Katafuchi, Hidetoshi Kanai, Masaru Nakayama, Hideki Hirakata, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   37 ( 11 )   993 - 998   2014.11

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    DOI: 10.1038/hr.2014.110

  • Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension

    Kiichiro Fujisaki, Kazuhiko Tsuruya, Toshiaki Nakano, Masatomo Taniguchi, Harumichi Higashi, Ritsuko Katafuchi, Hidetoshi Kanai, Masaru Nakayama, Hideki Hirakata, Takanari Kitazono

    HYPERTENSION RESEARCH   37 ( 11 )   993 - 998   2014.11

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    DOI: 10.1038/hr.2014.110

  • Relationship Between Residual Renal Function and Serum Fibroblast Growth Factor 23 in Patients on Peritoneal Dialysis Reviewed

    Shunsuke Yamada, Kazuhiko Tsuruya, Masatomo Taniguchi, Hisako Yoshida, Masanori Tokumoto, Shoko Hasegawa, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   18 ( 5 )   383 - 390   2014.10

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    DOI: 10.1111/1744-9987.12170

  • Relationship Between Residual Renal Function and Serum Fibroblast Growth Factor 23 in Patients on Peritoneal Dialysis

    Shunsuke Yamada, Kazuhiko Tsuruya, Masatomo Taniguchi, Hisako Yoshida, Masanori Tokumoto, Shoko Hasegawa, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Takanari Kitazono

    THERAPEUTIC APHERESIS AND DIALYSIS   18 ( 5 )   383 - 390   2014.10

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    DOI: 10.1111/1744-9987.12170

  • Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia Reviewed

    Shunsuke Yamada, Masanori Tokumoto, Narihito Tatsumoto, Masatomo Taniguchi, Hideko Noguchi, Toshiaki Nakano, Kosuke Masutani, Hiroaki Ooboshi, Kazuhiko Tsuruya, Takanari Kitazono

    American Journal of Physiology - Renal Physiology   306 ( 12 )   F1418 - F1428   2014.6

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    DOI: 10.1152/ajprenal.00633.2013

  • Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia

    Shunsuke Yamada, Masanori Tokumoto, Narihito Tatsumoto, Masatomo Taniguchi, Hideko Noguchi, Toshiaki Nakano, Kosuke Masutani, Hiroaki Ooboshi, Kazuhiko Tsuruya, Takanari Kitazono

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   306 ( 12 )   F1418 - F1428   2014.6

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    DOI: 10.1152/ajprenal.00633.2013

  • PERIVASCULAR LYMPHATIC VESSELS POTENTIALLY PRESERVE ALLOGRAFT FUNCTION IN KIDNEY TRANSPLANT PATIENTS

    Tsuchimoto Akihiro, Nakano Toshiaki, Masutani Kosuke, Matsukuma Yuta, Kitada Hidehisa, Noguchi Hideko, Tsuruya Kazuhiko, Tanaka Masao, Kitazono Takanari

    NEPHROLOGY   19   158 - 158   2014.5

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  • Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice Neuroprotective effect of tempol Reviewed

    Kiichiro Fujisaki, Kazuhiko Tsuruya, Mayumi Yamato, Jiro Toyonaga, Hideko Noguchi, Toshiaki Nakano, Masatomo Taniguchi, Masanori Tokumoto, Hideki Hirakata, Takanari Kitazono

    Nephrology Dialysis Transplantation   29 ( 3 )   529 - 538   2014.3

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    DOI: 10.1093/ndt/gft327

  • Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol

    Kiichiro Fujisaki, Kazuhiko Tsuruya, Mayumi Yamato, Jiro Toyonaga, Hideko Noguchi, Toshiaki Nakano, Masatomo Taniguchi, Masanori Tokumoto, Hideki Hirakata, Takanari Kitazono

    NEPHROLOGY DIALYSIS TRANSPLANTATION   29 ( 3 )   529 - 538   2014.3

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    DOI: 10.1093/ndt/gft327

  • Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study

    Toshiaki Nakano, Toshiharu Ninomiya, Shinji Sumiyoshi, Mitsuho Onimaru, Hiroshi Fujii, Hiroyuki Itabe, Yutaka Nakashima, Katsuo Sueishi, Kazuhiko Tsuruya, Yoshinao Oda, Takanari Kitazono, Yutaka Kiyohara

    KIDNEY INTERNATIONAL   84 ( 2 )   373 - 380   2013.8

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    DOI: 10.1038/ki.2013.111

  • The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis Reviewed

    Shunsuke Yamada, Kazuhiko Tsuruya, Hisako Yoshida, Masatomo Taniguchi, Naoki Haruyama, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Takanari Kitazono

    Clinical Endocrinology   78 ( 6 )   844 - 851   2013.6

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    DOI: 10.1111/cen.12070

  • The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis

    Shunsuke Yamada, Kazuhiko Tsuruya, Hisako Yoshida, Masatomo Taniguchi, Naoki Haruyama, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Takanari Kitazono

    CLINICAL ENDOCRINOLOGY   78 ( 6 )   844 - 851   2013.6

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    DOI: 10.1111/cen.12070

  • The Intertwine Between Coagulation Pathways and Autophagy in Hepatocellular Carcinoma

    Ming-Chao Tsai, Chih-Che Lin, Hsiang-Jen Yang, Kuang-Den Chen, Toshiaki Nakano, Chao-Long Chen

    GASTROENTEROLOGY   142 ( 5 )   S988 - S988   2012.5

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  • Effectiveness of lanthanum carbonate treatment used in combination with other phosphate binders in peritoneal dialysis patients Reviewed

    Shunsuke Yamada, Hisako Yoshida, Masatomo Taniguchi, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Internal Medicine   51 ( 16 )   2097 - 2104   2012

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    DOI: 10.2169/internalmedicine.51.6814

  • Validation of the exit-site scoring system recommended by the 2005 guidelines of the international society for peritoneal dialysis Reviewed

    M. Eriguchi, K. Tsuruya, H. Yoshida, S. Yamada, S. Tanaka, T. Suehiro, T. Nakano, M. Taniguchi

    Peritoneal Dialysis International   31 ( 6 )   698 - 700   2011.11

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    DOI: 10.3747/pdi.2010.00287

  • Association of Kidney Function With Coronary Atherosclerosis and Calcification in Autopsy Samples From Japanese Elders: The Hisayama Study

    Toshiaki Nakano, Toshiharu Ninomiya, Shinji Sumiyoshi, Hiroshi Fujii, Yasufumi Doi, Hideki Hirakata, Kazuhiko Tsuruya, Mitsuo Iida, Yutaka Kiyohara, Katsuo Sueishi

    AMERICAN JOURNAL OF KIDNEY DISEASES   55 ( 1 )   21 - 30   2010.1

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    DOI: 10.1053/j.ajkd.2009.06.034

  • VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B Reviewed

    Mitsuho Onimaru, Yoshikazu Yonemitsu, Takaaki Fujii, Mitsugu Tanii, Toshiaki Nakano, Kazunori Nakagawa, Ri Ichiro Kohno, Mamoru Hasegawa, Shin Ichi Nishikawa, Katsuo Sueishi

    American Journal of Physiology - Heart and Circulatory Physiology   297 ( 5 )   H1685 - H1696   2009.11

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    DOI: 10.1152/ajpheart.00015.2009

  • VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B

    Mitsuho Onimaru, Yoshikazu Yonemitsu, Takaaki Fujii, Mitsugu Tanii, Toshiaki Nakano, Kazunori Nakagawa, Ri-ichiro Kohno, Mamoru Hasegawa, Shin-ichi Nishikawa, Katsuo Sueishi

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   297 ( 5 )   H1685 - H1696   2009.11

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    DOI: 10.1152/ajpheart.00015.2009

  • Autocrine Loop between Vascular Endothelial Growth Factor (VEGF)-C and VEGF Receptor-3 Positively Regulates Tumor-Associated Lymphangiogenesis in Oral Squamoid Cancer Cells

    Masaki Matsuura, Mitsuho Onimaru, Yoshikazu Yonemitsu, Hanako Suzuki, Toshiaki Nakano, Hiroaki Ishibashi, Kanemitsu Shirasuna, Katsuo Sueishi

    AMERICAN JOURNAL OF PATHOLOGY   175 ( 4 )   1709 - 1721   2009.10

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    DOI: 10.2353/ajpath.2009.081139

  • Autocrine Loop between Vascular Endothelial Growth Factor (VEGF)-C and VEGF Receptor-3 Positively Regulates Tumor-Associated Lymphangiogenesis in Oral Squamoid Cancer Cells Reviewed

    Masaki Matsuura, Mitsuho Onimaru, Yoshikazu Yonemitsu, Hanako Suzuki, Toshiaki Nakano, Hiroaki Ishibashi, Kanemitsu Shirasuna, Katsuo Sueishi

    American Journal of Pathology   175 ( 4 )   1709 - 1721   2009

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    DOI: 10.2353/ajpath.2009.081139

  • A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction Reviewed

    39 ( 2 )   212 - 217   2007.2

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    Cerebral infarction is the most common type of stroke and often causes long-term disability. To investigate the genetic contribution to cerebral infarction, we conducted a case-control study using 52,608 gene-based tag SNPs selected from the JSNP database. Here we report that a nonsynonymous SNP in a member of protein kinase C (PKC) family, PRKCH, was significantly associated with lacunar infarction in two independent Japanese samples (P = 5.1 × 10-7, crude odds ratio of 1.40). This SNP is likely to affect PKC activity. Furthermore, a 14-year follow-up cohort study in Hisayama (Fukuoka, Japan) supported involvement of this SNP in the development of cerebral infarction (P = 0.03, age- and sex-adjusted hazard ratio of 2.83). We also found that PKCη was expressed mainly in vascular endothelial cells and foamy macrophages in human atherosclerotic lesions, and its expression increased as the lesion type progressed. Our results support a role for PRKCH in the pathogenesis of cerebral infarction.

    DOI: 10.1038/ng1945

  • 血管新生因子VEGFsによる動脈硬化進展に関する病態学的研究

    中野 敏昭, 鬼丸 満穂, 米満 吉和, 岡野 慎士, 居石 克夫

    日本病理学会会誌   96 ( 1 )   220 - 220   2007.2

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  • A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction

    Michiaki Kubo, Jun Hata, Toshiharu Ninomiya, Koichi Matsuda, Koji Yonemoto, Toshiaki Nakano, Tomonaga Matsushita, Keiko Yamazaki, Yozo Ohnishi, Susumu Saito, Takanari Kitazono, Setsuro Ibayashi, Katsuo Sueishi, Mitsuo Iida, Yusuke Nakamura, Yutaka Kiyohara

    NATURE GENETICS   39 ( 2 )   212 - 217   2007.2

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    DOI: 10.1038/ng1945

  • Actions of ZD0947, a novel ATP-sensitive K + channel opener, on membrane currents in human detrusor myocytes Reviewed

    M. Aishima, T. Tomoda, T. Yunoki, T. Nakano, N. Seki, Y. Yonemitsu, K. Sueishi, S. Naito, Y. Ito, N. Teramoto

    British Journal of Pharmacology   149 ( 5 )   542 - 550   2006.11

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    DOI: 10.1038/sj.bjp.0706893

  • Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes Reviewed

    M. Aishima, T. Tomoda, T. Yunoki, T. Nakano, N. Seki, Y. Yonemitsu, K. Sueishi, S. Naito, Y. Ito, N. Teramoto

    BRITISH JOURNAL OF PHARMACOLOGY   149 ( 5 )   542 - 550   2006.11

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    DOI: 10.1038/sj.bjp.0706893

  • The regulation of vascular endothelial growth factors (VEGF-A -C, and -D) expression in the retinal pigment epithelium

    Yasuhiro Ikeda, Yoshikazu Yonemitsu, Mitsuho Onimaru, Toshiaki Nakano, Masanori Miyazaki, Ri-Ichiro Kohno, Kazunori Nakagawa, Akifumi Ueno, Katsuo Sueishi, Tatsuro Ishibashi

    EXPERIMENTAL EYE RESEARCH   83 ( 5 )   1031 - 1040   2006.11

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    DOI: 10.1016/j.exer.2006.05.007

  • Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization - Critical role of the inflammatory/arteriogenic pathway

    Takaaki Fujii, Yoshikazu Yonemitsu, Mitsuho Onimaru, Mitsugu Tanii, Toshiaki Nakano, Kensuke Egashira, Takako Takehara, Makoto Inoue, Mamoru Hasegawa, Hiroyuki Kuwano, Katsuo Sueishi

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   26 ( 11 )   2483 - 2489   2006.11

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    DOI: 10.1161/01.ATV.0000244684.23499.bf

  • The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium Reviewed

    Yasuhiro Ikeda, Yoshikazu Yonemitsu, Mitsuho Onimaru, Toshiaki Nakano, Masanori Miyazaki, Ri ichiro Kohno, Kazunori Nakagawa, Akifumi Ueno, Katsuo Sueishi, Tatsuro Ishibashi

    Experimental Eye Research   83 ( 5 )   1031 - 1040   2006.11

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    DOI: 10.1016/j.exer.2006.05.007

  • Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization Critical role of the inflammatory/arteriogenic pathway Reviewed

    Takaaki Fujii, Yoshikazu Yonemitsu, Mitsuho Onimaru, Mitsugu Tanii, Toshiaki Nakano, Kensuke Egashira, Takako Takehara, Makoto Inoue, Mamoru Hasegawa, Hiroyuki Kuwano, Katsuo Sueishi

    Arteriosclerosis, thrombosis, and vascular biology   26 ( 11 )   2483 - 2489   2006.11

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    DOI: 10.1161/01.ATV.0000244684.23499.bf

  • 血管新生因子VEGF familyによる動脈硬化進展に関する病態学的研究

    中野 敏昭, 米満 吉和, 岡野 慎士, 居石 克夫

    脈管学   46 ( Suppl. )   S214 - S214   2006.9

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  • 血管新生関連因子VEGF-A,VEGF-Cの動脈硬化進展に関する病態学的研究

    中野 敏昭, 米満 吉和, 居石 克夫

    日本動脈硬化学会総会プログラム・抄録集   38回   267 - 267   2006.7

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  • 口腔扁平上皮癌におけるVEGF-C/VEGFR3(FLT-4)オートクラインループの病態学的意義

    松浦 理城, 鬼丸 満穂, 米満 吉和, 藤井 孝明, 中野 敏昭, 白砂 兼光, 居石 克夫

    日本病理学会会誌   95 ( 1 )   223 - 223   2006.4

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  • FGF-2血管新生遺伝子治療 VEGF-C/Flt-4とPDGF-BB/PDGFR-β連関のパラクライン的相互作用の重要性

    鬼丸 満穂, 米満 吉和, 中野 敏昭, 谷井 貢, 藤井 孝明, 向野 利一郎, 中川 和憲, 居石 克夫

    日本血栓止血学会誌   16 ( 5 )   529 - 529   2005.10

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  • 口腔扁平上皮癌におけるVEGF-C/VEGFR3(FLT-4)オートクラインループの意義

    松浦 理城, 鬼丸 満穂, 米満 吉和, 藤井 孝明, 中野 敏昭, 白砂 兼光, 居石 克夫

    脈管学   45 ( 10 )   823 - 823   2005.10

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  • マウス虚血下肢へのFGF-2遺伝子治療におけるVEGF-C/Flt-4連関ならびにPDGF-BB/PDGFR-β連関のパラクライン的相互作用の重要性

    鬼丸 満穂, 米満 吉和, 中野 敏昭, 谷井 貢, 藤井 孝明, 向野 利一郎, 中川 和憲, 居石 克夫

    脈管学   45 ( 10 )   820 - 820   2005.10

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  • Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques Reviewed

    Hiromitsu Baba, Yoshikazu Yonemitsu, Toshiaki Nakano, Mitsuho Onimaru, Masanori Miyazaki, Yasuhiro Ikeda, Shinji Sumiyoshi, Yasuji Ueda, Mamoru Hasegawa, Ichiro Yoshino, Yoshihiko Maehara, Katsuo Sueishi

    Arteriosclerosis, thrombosis, and vascular biology   25 ( 9 )   1938 - 1944   2005.9

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    DOI: 10.1161/01.ATV.0000175759.78338.1e

  • Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas Reviewed

    Yasunori Shikada, Yoshikazu Yonemitsu, Takaomi Koga, Mitsuho Onimaru, Toshiaki Nakano, Shinji Okano, Shihoko Sata, Kazunori Nakagawa, Ichiro Yoshino, Yoshihiko Maehara, Katsuo Sueishi

    Cancer Research   65 ( 16 )   7241 - 7248   2005.8

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    DOI: 10.1158/0008-5472.CAN-04-4171

  • Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas. International journal

    Yasunori Shikada, Yoshikazu Yonemitsu, Takaomi Koga, Mitsuho Onimaru, Toshiaki Nakano, Shinji Okano, Shihoko Sata, Kazunori Nakagawa, Ichiro Yoshino, Yoshihiko Maehara, Katsuo Sueishi

    Cancer research   65 ( 16 )   7241 - 8   2005.8

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  • マウス虚血下肢のFGF-2遺伝子治療におけるVEGF-C/Flt-4連関ならびにPDGF-BB/PDGFR-β連関のパラクライン的相互作用の重要性

    鬼丸 満穂, 米満 吉和, 谷井 貢, 藤井 孝明, 向野 利一郎, 中野 敏昭, 中川 和憲, 居石 克夫

    日本動脈硬化学会総会プログラム・抄録集   37回   205 - 205   2005.7

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  • 動脈硬化の最前線 基礎から臨床 動脈硬化の発生・進展機序 「炎症・修復説」の観点から

    米満 吉和, 中野 敏昭, 馬場 博充, 住吉 真治, 中島 豊, 居石 克夫

    脈管学   45 ( 7 )   415 - 421   2005.7

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  • ヒト膀胱平滑筋型ATP感受性カリウムチャネルのイオンチャネルポアの分子薬理学的解析

    相島 真奈美, 柚木 貴和, 寺本 憲功, 中野 敏昭, 米満 吉和, 居石 克夫, 関 成人, 伊東 祐之, 内藤 誠二

    日本泌尿器科学会雑誌   96 ( 2 )   268 - 268   2005.3

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  • ヒト膀胱平滑筋における電位依存性L型カルシウム電流に及ぼすFlavoxateの効果

    友田 稔久, 相島 真奈美, 寺本 憲功, 高野 徳昭, 中野 敏昭, 米満 吉和, 居石 克夫, 関 成人, 伊東 祐之, 内藤 誠二

    日本泌尿器科学会雑誌   96 ( 2 )   269 - 269   2005.3

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  • The effects of flavoxate hydrochloride on voltage-dependent L-type Ca 2+ currents in human urinary bladder Reviewed

    Toshihisa Tomoda, Manami Aishima, Naruaki Takano, Toshiaki Nakano, Narihito Seki, Yoshikazu Yonemitsu, Katsuo Sueishi, Seiji Naito, Yushi Ito, Noriyoshi Teramoto

    British Journal of Pharmacology   146 ( 1 )   25 - 32   2005

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    DOI: 10.1038/sj.bjp.0706284

  • 血管新生抑制因子 網膜色素上皮由来因子(PEDF)のヒト動脈硬化巣における発現と分布

    馬場 博充, 米満 吉和, 池田 康博, 宮崎 勝徳, 住吉 真治, 中野 敏昭, 居石 克夫

    日本血栓止血学会誌   15 ( 5 )   482 - 482   2004.10

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  • ヒト冠動脈硬化内膜におけるVEGF-CおよびDの発現に関する免疫組織化学的検討

    中野 敏昭, 中島 豊, 米満 吉和, 住吉 真治, 秋嶋 由里, 石井 壽晴, 居石 克夫

    日本動脈硬化学会総会プログラム・抄録集   36回   189 - 189   2004.7

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  • 血管新生抑制因子 網膜色素上皮由来因子(PEDF)のヒト動脈硬化巣における発現と分布

    馬場 博充, 米満 吉和, 池田 康博, 宮崎 勝徳, 住吉 真治, 中野 敏昭, 居石 克夫

    日本動脈硬化学会総会プログラム・抄録集   36回   190 - 190   2004.7

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  • ヒト冠動脈硬化内膜におけるVEGF-C及びDの発現に関する免疫組織学的検討

    中野 敏昭, 中島 豊, 米満 吉和, 住吉 真治, 秋嶋 由里, 石井 壽晴, 居石 克夫

    日本病理学会会誌   93 ( 1 )   361 - 361   2004.5

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  • 血管新生抑制因子 網膜色素上皮由来因子(PEDF)のヒト動脈硬化巣における発現と分布

    馬場 博充, 米満 吉和, 池田 康博, 宮崎 勝徳, 住吉 真治, 中野 敏昭, 居石 克夫

    日本病理学会会誌   93 ( 1 )   361 - 361   2004.5

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  • ヒト冠動脈硬化内膜におけるVEGF-C及びDの発現の検討

    中野 敏昭, 中島 豊, 米満 吉和, 住吉 真治, 居石 克夫

    日本血栓止血学会誌   14 ( 5 )   426 - 426   2003.10

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  • ヒト冠動脈硬化内膜におけるVEGF-C及びDの発現の検討

    中野 敏昭, 中島 豊, 米満 吉和, 住吉 真治, 居石 克夫

    脈管学   43 ( 9 )   502 - 502   2003.9

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Books

  • 「コリンエステラーゼ」透析患者の検査値の読み方第4版

    中野敏昭( Role: Joint author)

    日本メディカルセンター  2019.1 

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Presentations

  • 慢性腎臓病患者におけるTIBC値と腎予後の関係:福岡腎臓病データベース(FKR)研究

    中野敏昭, 田中茂, 北村博雅, 冷牟田浩人, 岡村員裕, 鶴屋和彦, 北園孝成

    第66回日本腎臓学会学術総会  2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Country:Japan  

  • 透析患者の低栄養 現状と対策のoverview Invited

    中野敏昭

    第68回日本透析医学会学術集会・総会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 透析患者における悪性腫瘍:スクリーニングとその対策 Invited

    中野敏昭

    第68回日本透析医学会学術集会・総会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 血液透析患者における脈圧と脳梗塞、脳出血発症との関連~Qコホート研究~

    中野敏昭, 冷牟田浩人, 田中茂, 北村博雅, 谷口正智, 鶴屋和彦, 北園孝成

    第66回日本透析医学会学術集会・総会  2022.5 

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    Event date: 2023.6 - 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 多併存疾患を伴うCKD治療戦略~福岡腎臓病データベース研究(FKR)の知見より~ Invited

    中野敏昭

    第67回日本透析医学会学術集会・総会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • CKDにおける冠動脈病変の病理像 Invited

    中野敏昭

    第65回日本腎臓学会学術総会  2022.6 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • The impact of calcification on intraplaque hemorrhage in coronary atherosclerosis from autopsy samples: the Hisayama Study International conference

    Toshiaki Nakano, Hiromasa Kitamura, Yoshinao Oda, Takanari Kitazono,Toshiharu Ninomiya

    19th Asian Pacific Congress of Nephrology  2021.8 

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    Event date: 2021.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • The impact of calcification on intraplaque hemorrhage in coronary atherosclerosis from autopsy samples: the Hisayama Study

    Toshiaki Nakano, Hiromasa Kitamura, Yoshinao Oda, Takanari Kitazono,Toshiharu Ninomiya

    2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Qコホート研究から得られた血液透析患者における脳血管障害の特徴 Invited

    中野敏昭

    第66回日本透析医学会学術集会・総会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Higher cholesterol level predicts cardiovascular event and inversely associates with mortality in hemodialysis patients: 10-year outcomes of the Q-Cohort Study Invited

    Toshiaki Nakano, Hiroto Hiyamuta, Ryusuke Yotsueda, Shigeru Tanaka, Masatomo Taniguchi, Kazuhiko Tsuruya, Takanari Kitazono

    2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • CKD患者における野菜、果物、βカロテン摂取量の検討: 福岡腎臓病データベース(FKR)研究

    中野敏昭、田中茂、鶴屋和彦 、北園孝成

    第64回日本腎臓学会学術総会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 透析患者の病態(合併症)を診る-脂質管理:日常検査の視点から- Invited

    @中野敏昭

    第65回日本透析医学会学術集会・総会  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • CKD患者のカリウム管理の重要性~Fukuoka Kidney Registryの結果より~ Invited

    @中野敏昭

    第50回日本腎臓学会西部学術大会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:和歌山   Country:Japan  

  • 中性液での腹膜透析におけるEPSの予測因子の検討

    @中野敏昭、辻川浩明、@恒吉章治、@鳥巣久美子、鶴屋和彦、@北園孝成

    第26回日本腹膜透析医学会学術集会・総会  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • CKD患者における腹囲と脂質異常症の関係: 福岡腎臓病データベース(FKR)研究 International conference

    @中野敏昭, @田中茂, 鶴屋和彦, @北園孝成

    第63回日本腎臓学会学術総会  2020.8 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • CKD患者の管理と最新の治療法 Invited

    @中野敏昭

    第26回日本心臓リハビリテーション学会学術集会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • CKD患者の動脈硬化と心血管病 Invited

    @中野敏昭

    第52回日本動脈硬化学会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • The target cholesterol level for favorable prognosis in hemodialysis patients: 10-Year outcomes of the Q-Cohort Study International conference

    @Toshiaki Nakano, @Hiroto Hiyamuta, @Ryusuke Yotsueda, @Shigeru Tanaka, Masatomo Taniguchi, Kazuhiko Tsuruya, @Takanari Kitazono

    American Society of Nephrology, Kidney Week 2011 Annual Meeting  2019.11 

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    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • CKD患者の心血管合併症 Invited

    @中野敏昭

    第49回日本腎臓学会西部学術大会  2019.10 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高知   Country:Japan  

  • 血液透析患者の総コレステロール値と心血管病発症および生命予後の関係 ~Qコホート研究10年予後調査~

    @中野敏昭, @冷牟田浩人, @四枝龍佑, 谷口正智, 鶴屋和彦, @北園孝成

    第64回日本透析医学会学術集会・総会  2019.6 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • CKDステージと脂質異常症の関係:福岡腎臓病データベース(FKR)研究

    @中野敏昭, @田中茂, 鶴屋和彦, @北園孝成

    第62回日本腎臓学会学術総会  2019.6 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 腹膜透析中止期における腹膜毛細血管数の腹膜機能への影響

    @中野 敏昭

    第18回日本腹膜透析医学会学術集会・総会  2012.9 

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    Event date: 2012.9

    Language:Japanese  

    Venue:徳島県徳島市   Country:Japan  

  • The Effect of kidney function on intimal neovascularization and intraplaque hemorrhage in coronary atherosclerosis: the Hisayama Study. International conference

    @Nakano T, @Ninomiya T, @Onimaru M, Tsuruya K, Kiyohara Y, @Kitazono T

    American Society of Nephrology, Kidney Week 2011 Annual Meeting  2011.11 

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    Event date: 2011.11

    Language:English  

    Country:Japan  

  • 腎機能障害による冠状動脈内血管新生と内膜内出血への影響

    @中野敏昭、二宮利治、鬼丸瑞穂、鶴屋和彦、清原裕、北園孝成

    第54回日本腎臓学会学術総会  2011.6 

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    Event date: 2011.6

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 腹膜透析導入時における腹膜毛細血管数の腹膜機能への影響

    @中野敏昭、江里口雅裕、田中茂、吉田寿子、谷口正智、鶴屋和彦

    第16回日本腹膜透析医学会学術集会・総会  2010.11 

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    Event date: 2010.11

    Language:Japanese  

    Venue:大分   Country:Japan  

  • GNRIを利用した栄養評価と生命予後の検討~Q-Cohort Study~

    @中野敏昭 谷口正智 山田俊輔 鶴屋和彦 平方秀樹 飯田三雄

    第55回日本透析医学会学術集会・総会  2010.6 

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    Event date: 2010.6

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 腎機能と冠状動脈硬化病変における酸化LDL、慢性炎症との関連

    @中野敏昭  二宮利治  鶴屋和彦 鬼丸瑞穂 清原裕 飯田三雄

    第53回日本腎臓学会学術総会  2010.6 

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    Event date: 2010.6

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. International conference

    @Nakano T, Ninomiya T, Tsuruya K, Iida M, Kiyohara Y, Sueishi K.

    International Society of Nephrology  2010.5 

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    Event date: 2010.5

    Language:English  

    Country:Japan  

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MISC

  • Direct and indirect effects of fibroblast growth factor 23 on the heart. Reviewed

    Nakano T, Kishimoto H, Tokumoto M.

    Frontier Endocrinology   2023.5

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  • GENOME-WIDE ASSOCIATION STUDY FOR THE ONSET OF CHRONIC KIDNEY DISEASE IN JAPANESE POPULATION

    Yuka Sugawara, Yosuke Hirakawa, Hajime Nagasu, Akira Narita, Jun Wada, Takashi Wada, Toshiaki Nakano, Motoko Yanagita, Ichiei Narita, Seizo Koshiba, Gen Tamiya, Masaomi Nangaku, Masayuki Yamamoto, Naoki Kashihara

    NEPHROLOGY   2021.8

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  • 1年プロトコル生検における慢性活動性T細胞関連拒絶の意義

    中川 兼康, 土本 晃裕, 植木 研次, 加来 啓三, 野口 浩司, 岡部 安博, 角田 洋一, 奥見 雅由, 升谷 耕介, 中野 敏昭, 田邉 一成, 北園 孝成

    日本臨床腎移植学会プログラム・抄録集   2020.2

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    Language:Japanese  

  • 抗糸球体基底膜病による腎不全患者に対する腎移植成績 JACK研究

    植木 研次, 土本 晃裕, 升谷 耕介, 中川 兼康, 加来 啓三, 野口 浩司, 岡部 安博, 角田 洋一, 奥見 雅由, 佐藤 優, 大田 守仁, 中野 敏昭, 田邉 一成, 北園 孝成

    日本臨床腎移植学会プログラム・抄録集   2020.2

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    Language:Japanese  

  • The Ankle-Brachial Index and Risk of Chronic Kidney Disease. Reviewed

    Nakano T.

    J Atheroscler Thromb. 2019 Dec 1;26(12):1043-1044.   2019.12

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  • Methylglyoxal and immature angiogenesis. Reviewed

    Nakano T.

    IMARS Highlights. 2019 July 15;14(4):p11-14.   2019.7

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  • レニン・アンジオテンシン系阻害薬による腎移植レシピエントの心血管病発症の抑制効果

    土本 晃裕, 松隈 祐太, 植木 研次, 中川 兼康, 岡部 安博, 升谷 耕介, 奥見 雅由, 中野 敏昭, 田邉 一成, 北園 孝成

    日本腎臓学会誌   2019.5

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  • 地域高齢住民における慢性腎臓病と大脳白質病変の関連 久山町研究

    山崎 景介, 秦 淳, 高江 啓太, 古田 芳彦, 平林 直樹, 中野 敏昭, 北園 孝成, 二宮 利治

    日本動脈硬化学会総会プログラム・抄録集   2018.6

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  • 血液透析患者における全身性動脈硬化性疾患と心血管リスクの関係 Qコホート研究10年予後

    田中 茂, 二宮 利治, 冷牟田 浩人, 谷口 正智, 徳本 正憲, 中野 敏昭, 大星 博明, 北園 孝成, 鶴屋 和彦

    日本透析医学会雑誌   2018.5

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  • IgA腎症患者における血漿浸透圧と末期腎不全発症リスクの関連

    田中 茂, 二宮 利治, 徳本 正憲, 土本 晃裕, 中野 敏昭, 大星 博明, 北園 孝成, 鶴屋 和彦

    日本腎臓学会誌   2018.4

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  • Delta-Like Ligand 4-Notch Signaling in Macrophage Activation. Reviewed

    Nakano T, Fukuda D, Koga J, Aikawa M.

    Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2038-47.   2016.10

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  • 一般住民の連続剖検例における腎機能低下と左室肥大の関係 久山町研究

    伊豆丸 堅祐, 永田 雅治, 中島 豊, 中野 敏昭, 鶴屋 和彦, 小田 義直, 北園 孝成, 清原 裕, 二宮 利治

    日本腎臓学会誌   2016.5

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  • 腎機能障害による冠状動脈内新生血管と内膜内出血への影響

    中野 敏昭, 二宮 利治, 鬼丸 満穂, 鶴屋 和彦, 清原 裕

    日本腎臓学会誌   2011.5

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  • 腎機能と冠状動脈硬化病変における酸化LDL、慢性炎症との関連

    中野 敏昭, 二宮 利治, 鶴屋 和彦, 清原 裕, 飯田 三雄

    日本腎臓学会誌   2010.5

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  • 久山町剖検例における慢性腎臓病の冠状動脈硬化進展に与える影響

    中野 敏昭, 二宮 利治, 鶴屋 和彦, 飯田 三雄, 清原 裕, 居石 克夫

    日本腎臓学会誌   2007.4

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  • 久山町剖検例における慢性腎臓病の冠状動脈硬化進展に与える影響

    中野 敏昭, 二宮 利治, 清原 裕, 居石 克夫

    日本病理学会会誌   2007.2

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  • 全身性疾患と腎障害up to date 一般住民における慢性腎臓病と動脈硬化の関係 久山町研究

    二宮 利治, 中野 敏昭, 居石 克夫, 清原 裕

    日本腎臓学会誌   2006.8

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  • Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques

    H Baba, Y Yonemitsu, T Nakano, M Onimaru, M Miyazaki, Y Ikeda, S Sumiyoshi, Y Ueda, M Hasegawa, Yoshino, I, Y Maehara, K Sueishi

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   2005.9

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    DOI: 10.1161/01.ATV.0000175759.78338.1e

  • The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder

    T Tomoda, M Aishima, N Takano, T Nakano, N Seki, Y Yonemitsu, K Sueishi, S Naito, Y Ito, N Teramoto

    BRITISH JOURNAL OF PHARMACOLOGY   2005.9

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    DOI: 10.1038/sj.bjp.0706284

  • Inummohistochemical expressions of VEGF-C and D in the atherosclerotic intima of human coronary arteries

    T Nakano, Y Nakashima, Y Yonemitsu, S Sumiyoshi, K Sueishi

    ATHEROSCLEROSIS SUPPLEMENTS   2003.9

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Professional Memberships

  • The Japanese Society of Internal Medicine

  • Japanese Society of Nephrology

  • The Japanese Society for Dialysis Therapy

  • Japanese Atherosclerosis Society

  • Japanese Society for Clinical Renal Transplantation

  • American Society of Nephrology

  • International Society of Nephrology

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Academic Activities

  • 教育講演演者

    第68回日本透析医学会学術集会・総会  2023.6

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    Type:Competition, symposium, etc. 

  • ワークショップ演者

    第68回日本透析医学会学術集会・総会  2023.6

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • 座長

    第67回日本透析医学会学術集会総会  ( パシフィコ横浜 ) 2022.6

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • シンポジウム演者

    第65回日本腎臓学会学術総会  ( 神戸コンベンションセンター ) 2022.6

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • Journal of Atherosclerosis and Thrombosis International contribution

    2022.6 - 2025.6

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    Type:Academic society, research group, etc. 

  • Frontiers in Cardiovascular Medicine International contribution

    2021.6 - 2025.6

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    Type:Academic society, research group, etc. 

  • 九州人工透析研究会誌

    2018.1 - 2032.6

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    Type:Academic society, research group, etc. 

  • 座長(Chairmanship)

    第296回内科学会九州地方会  ( 福岡 ) 2012.1

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    Type:Competition, symposium, etc. 

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Research Projects

  • 抗加齢因子スペルミジンが腎臓、そして全身を守る

    Grant number:23K07675  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • ネフローゼ型膜性腎症に対するリツキシマブの検証的医師主導治験の実施

    2023 - 2024

    日本医療研究開発機構(AMED)臨床研究・治験推進研究事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 慢性腎臓病進行例(CKD G3b~G5)の予後向上のための予後、合併症、治療に関するコホート研究(REACH-J-CKD cohort)

    2023

    受託研究

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    Authorship:Principal investigator  Grant type:Contract research

  • 石灰化進行抑制薬として用いるCalciprotein particles(CPP)形成抑制剤の研究

    2023

    共同研究 (冨田製薬株式会社)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 腹膜透析による腹膜線維化と石灰化の病態解明~リンの関与とマグネシウムの競合作用

    Grant number:22K08355  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 腎機能障害におけるLuseogliflozinの保護作用の機序の解明

    2022

    共同研究 (大正製薬株式会社)

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    Authorship:Principal investigator  Grant type:Contract research

  • 慢性腎臓病患者の健康生活支援を目指した口腔機能管理・食支援プログラムの開発

    Grant number:21H03265  2021 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 腸内細菌叢メタゲノムおよびメタボローム情報を用いた腎疾患診断モデルの構築

    Grant number:21H03201  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 移植腎に形成される三次リンパ組織が長期移植腎機能に与える影響とその機序の解明

    Grant number:21K08607  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 慢性腎臓病における心筋肥大の機序解明

    Grant number:21K08232  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 慢性腎臓病における心筋肥大の機序解明

    Grant number:21K08232  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 慢性腎臓病における心筋肥大の機序解明

    2021 - 2022

    日本腎臓財団

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    Authorship:Principal investigator  Grant type:Contract research

  • アルギニン代謝とオートファジー~腎臓のミトコンドリア保護機構の解明

    Grant number:20K08610  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 糖尿病性腎症、慢性腎臓病の重症化抑制に資する持続的・自立的エビデンス創出システム構築と健康寿命延伸・医療最適化への貢献

    2020 - 2022

    AMED 循環器疾患・糖尿病等生活習慣病対策実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 精緻な疾患レジストリーと遺伝・環境要因の包括的解析による糖尿病性腎臓病、慢性腎臓病の予後層別化と最適化医療の確立

    2020 - 2022

    AMED ゲノム医療実現推進プラットフォーム事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 骨格筋・血管相関の概念の応用による血管石灰化治療とその分子機構の究明

    Grant number:19K08706  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • The mechanism of atheroma progression in chronic kidney disease via Notch signaling

    2016 - 2017

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    Authorship:Principal investigator  Grant type:Contract research

  • 腎移植患者におけるPolyomavirus BK感染に関する前向き研究

    Grant number:25462540  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 腹膜透析診療チームで行う包括的腎臓リハビリテーション

    Grant number:24593302  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 血管新生因子による血管障害とその修復に関する病理学的研究

    Grant number:23590400  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 血管新生因子による血管障害とその修復に関する病理学的研究

    Grant number:23590400  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 血管新生因子による病的およびに機能的血管新生に対する病態学的研究

    Grant number:20590342  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 血管新生因子による血管病変増悪と修復に関する病態学的研究

    Grant number:20590342  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 腎不全による記憶障害に対する酸化ストレスの影響および苔状線維の変化とEPOの効果

    Grant number:20590959  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 血管新生因子による血管病変増悪と修復に関する病態学的研究

    Grant number:18890130  2006 - 2007

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

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Class subject

  • 検尿実習

    2023.10 - 2024.3   Second semester

  • 症候診断学

    2023.10 - 2024.3   Second semester

  • 腎臓内科学

    2023.4 - 2023.9   First semester

  • 動脈血ガス分析

    2023.4 - 2023.9   First semester

  • 腎・泌尿器生殖器概論

    2023.4 - 2023.9   First semester

  • 腎臓内科学

    2022.10 - 2023.3   Second semester

  • 検尿実習

    2022.10 - 2023.3   Second semester

  • 症候診断学

    2022.10 - 2023.3   Second semester

  • 腎臓内科学

    2022.4 - 2022.9   First semester

  • 動脈血ガス分析

    2022.4 - 2022.9   First semester

  • 腎・泌尿器生殖器概論

    2022.4 - 2022.9   First semester

  • 症候診断学

    2021.10 - 2022.3   Second semester

  • 検尿実習

    2021.10 - 2022.3   Second semester

  • 腎臓内科学

    2021.4 - 2021.9   First semester

  • 動脈血ガス分析

    2021.4 - 2021.9   First semester

  • 腎・泌尿器生殖器概論

    2021.4 - 2021.9   First semester

  • 腎臓内科学

    2020.10 - 2021.3   Second semester

  • 検尿実習

    2020.10 - 2021.3   Second semester

  • 症候診断学

    2020.10 - 2021.3   Second semester

  • 腎臓内科学

    2020.10 - 2021.3   Second semester

  • 腎臓内科学

    2020.4 - 2020.9   First semester

  • 動脈血ガス分析

    2020.4 - 2020.9   First semester

  • 腎・泌尿器生殖器概論

    2020.4 - 2020.9   First semester

  • 腎臓内科学

    2019.10 - 2020.3   Second semester

  • 検尿実習

    2019.10 - 2020.3   Second semester

  • 症候診断学

    2019.10 - 2020.3   Second semester

  • 腎臓内科学

    2019.4 - 2019.9   First semester

  • アレルギー膠原病感染症概論、中毒

    2019.4 - 2019.9   First semester

  • 動脈血ガス分析

    2019.4 - 2019.9   First semester

  • 腎・泌尿器生殖器概論

    2019.4 - 2019.9   First semester

  • 腎臓内科学

    2018.10 - 2019.3   Second semester

  • 検尿実習

    2018.10 - 2019.3   Second semester

  • 症候診断学

    2018.10 - 2019.3   Second semester

  • 腎臓内科学

    2018.10 - 2019.3   Second semester

  • 腎臓内科学

    2018.4 - 2018.9   First semester

  • アレルギー膠原病感染症概論、中毒

    2018.4 - 2018.9   First semester

  • 動脈血ガス分析

    2018.4 - 2018.9   First semester

  • 腎・泌尿器生殖器概論

    2018.4 - 2018.9   First semester

  • 腎臓内科学

    2012.10 - 2013.3   Second semester

  • 腎臓内科学

    2011.10 - 2012.3   Second semester

  • 腎臓内科

    2010.10 - 2011.3   Second semester

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Social Activities

  • 慢性腎臓病(CKD)市民公開講座

    福岡市医師会  天神スカイホール  2023.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 防ごう!透析患者の心血管病

    福腎協  電気ビル  2023.2

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 慢性腎臓病(CKD)とはどういう病気か

    飯塚医師会  飯塚医師会館  2019.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 慢性腎臓病の医師会での講演会

    日本医師会  医師会館  2019.2

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 慢性腎臓病(CKD)市民公開講座

    福岡市医師会  天神スカイホール  2004.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Travel Abroad

  • 2014.1 - 2017.12

    Staying countory name 1:United States   Staying institution name 1:Brigham and Women's Hospital, Harvard University

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Nephrology

Clinician qualification

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

  • Preceptor

    Japanese Society of Nephrology(JSN)

  • Preceptor

    The Japanese Society for Dialysis Therapy

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Preceptor

    The Japanese Society of Internal Medicine(JSIM)

Year of medical license acquisition

  • 1998

Notable Clinical Activities

  • 腎疾患の病棟患者の治療、外来腎疾患患者の治療、透析患者の診療、腎疾患患者の院内コンサルテーションに関して診療を行っている.