Updated on 2024/11/30

写真a

 
YAMAMURA KENICHIRO
 
Organization
Kyushu University Hospital Comprehensive Maternity and Perinatal Care Center Associate Professor
Title
Associate Professor
Profile
小児科循環器グループチーフとして、心臓病を持つ小児の診療・研究に携わっている。2009年にハートセンター成人先天性心疾患外来を開設し、循環器内科や他科と連携して、成人期に達した先天性心疾患患者の診療を専門的に行っている。福岡圏内の難治性川崎病の診療を担うと同時に、川崎病疾患感受性遺伝子解析の基礎研究を行っている。小児心筋症・心臓移植に関して、九州での中核施設としての役割を果たしている。また、小児期動脈硬化の生理学的バイオマーカーを用いた研究を行っている。
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Research Areas

  • Life Science / Embryonic medicine and pediatrics

  • Life Science / Cardiology

Degree

  • M.D., Ph.D.

Research Interests・Research Keywords

  • Research theme: clinical study of pediatric cardiology and adult congenital heart disease, genetic analysis of Kawasaki disease, Physiologic study of atherosclerosis in children

    Keyword: pediatric cardiology, adult congenital heart disease, Kawasaki disease, atherosclerosis

    Research period: 2008.4

Awards

  • Best Research Awards, 127th Annual Meeting of Japanese Society of Pediatrics

    2024.4   Japanese Society of Pediatrics  

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  • 第111回日本循環器学会九州地方会 Young Investigator's Award

    2011.12   日本循環器学会   Analysis of left ventricular function after pulmonary valve replacement in patients with tetralogy of Fallot

Papers

  • Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome Reviewed International journal

    Kenichiro Yamamura, Hidetoshi Takada, Kiyoshi Uike, Yasutaka Nakashima, Hazumu Nagata, Tomohito Takimoto, Masataka Ishimura, Eiji Morihana, Shouichi Ohga, Toshiro Hara

    2014.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Histo-blood group gene polymorphisms as potential genetic modifiers of the development of coronary artery lesions in patients with Kawasaki disease Reviewed International journal

    Yamamura K, Ihara K, Ikeda K, Nagata H, Mizuno Y, Hara T

    International Journal of Immunogenetics   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Thrombocytosis in asplenia syndrome with congenital heart disease: A previously unrecognized risk factor for thromboembolism Reviewed International journal

    Yamamura K, Joo K, Ohga S, Nagata H, Ikeda K, Muneuchi J, Watanabe M, Hara T

    International Journal of Cardiology   2012.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Dural arteriovenous fistulae in a 6-year-old girl with trisomy 21 and congenital heart disease. International journal

    Toshiya Ishikura, Yuri Sonoda, Kenta Kajiwara, Pin Fee Chong, Hikaru Kanemasa, Yoshitomo Motomura, Noriyuki Kaku, Yuichiro Hirata, Hazumu Nagata, Kenichiro Yamamura, Koichi Arimura, Akira Nakamizo, Yasunari Sakai, Shouichi Ohga

    Clinical neurology and neurosurgery   246   108540 - 108540   2024.11   ISSN:0303-8467 eISSN:1872-6968

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Clinical Neurology and Neurosurgery  

    Dural arteriovenous fistula (DAVF) represents a pathological group of intracranial shunts arising from the dural artery to venous sinus and veins. Childhood-onset DAVF is generally considered to be poor in prognosis, whereas only limited information is available for the onset and long-term outcomes. We herein report a Japanese girl with trisomy 21, large ventricular septal defects, and pulmonary vein stenosis, for which a transcatheter stent had been placed after birth. At age 6 years, she developed bacterial meningitis due to S. pneumoniae, leading to the diagnosis of venous sinus thrombosis and multiple intracranial shunts. Cerebral angiography identified multiple shunts arising from the middle meningeal arteries to the superior sagittal sinus and a concurrent reflux to cortical vein. Endovascular embolization successfully occluded the shunts without neurovascular complications over 24 months. This report first demonstrates the favorable outcome of DAVF in a pediatric patient with trisomy 21 after the catheter intervention. For children at a risk for intracranial thrombosis, preemptive neurovascular evaluation and transcatheter intervention provide a chance of early diagnosis of DAVF to improve their survival and neurologic outcome.

    DOI: 10.1016/j.clineuro.2024.108540

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  • Respiratory viral infections and Kawasaki disease: A molecular epidemiological analysis. International journal

    Kentaro Marutani, Kenji Murata, Yumi Mizuno, Sagano Onoyama, Takayuki Hoshina, Kenichiro Yamamura, Kenji Furuno, Yasunari Sakai, Junji Kishimoto, Koichi Kusuhura, Toshiro Hara

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi   57 ( 5 )   691 - 699   2024.10   ISSN:1684-1182 eISSN:1995-9133

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Microbiology, Immunology and Infection  

    BACKGROUND/PURPOSE: Recent large-scale epidemiological studies have revealed significant temporal associations between certain viral infections and the subsequent development of Kawasaki disease (KD). Despite these associations, definitive laboratory evidence linking acute or recent viral infections to KD cases remains elusive. The objective of this study is to employ a molecular epidemiological approach to investigate the temporal association between viral infections and the development of KD. METHODS: We analyzed 2460 patients who underwent the FilmArray® Respiratory Panel test between April 2020 and September 2021. RESULTS: Following the application of inclusion criteria, 2402 patients were categorized into KD (n = 148), respiratory tract infection (n = 1524), and control groups (n = 730). The KD group exhibited higher positive rates for respiratory syncytial virus (RSV), human rhinovirus/enterovirus (hRV/EV), parainfluenza virus (PIV) 3, and adenovirus (AdV) compared to the control group. Additionally, coinfections involving two or more viruses were significantly more prevalent in the KD group. Notably, RSV-positive, hRV/EV-positive, and PIV3-positive KD patients exhibited a one-month delay in peak occurrence compared to non-KD patients positive for corresponding viruses. In contrast, AdV-positive KD cases did not show a one-month delay in peak occurrence. Moreover, anti-RSV, anti-PIV3, and anti-AdV antibody-positive rates or antibody titers were higher in RSV-, PIV3-, and AdV-positive KD cases, respectively, compared to non-KD cases with the same viral infections. CONCLUSION: Recent infection with RSV, PIV3, or AdV, occasionally in conjunction with other viruses, may contribute to the pathogenesis of KD as infrequent complications.

    DOI: 10.1016/j.jmii.2024.07.001

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Books

  • 成人先天性心疾患パーフェクトガイド

    山村 健一郎, 赤木禎二(Role:Joint author)

    文光堂  2015.9 

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    Responsible for pages:「Senning/Mustard手術とは─遠隔期の問題と再手術─」「Unifocalizationとは –適応と遠隔期の問題-」   Language:Japanese   Book type:General book, introductory book for general audience

  • SHD/ACHDのCT・MRI

    山村 健一郎, 丹羽 公一郎(Role:Joint author)

    2015.3 

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    Responsible for pages:「大血管系の形態評価◦大動脈縮窄の形態,術後再狭窄の評価」「単心室・Fontan循環」   Language:Japanese   Book type:Scholarly book

  • 成人先天性心疾患

    山村 健一郎, 丹羽 公一郎(Role:Joint author)

    メジカルビュー社  2015.2 

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    Responsible for pages:「心室中隔欠損・Valsalva洞動脈瘤」   Language:Japanese   Book type:Scholarly book

  • 成人先天性心疾患の心エコー

    山村 健一郎, 丹羽 公一郎(Role:Joint author)

    ベクトル・コア  2014.10 

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    Responsible for pages:「心室中隔欠損」「Fallot四徴症、肺動脈閉鎖」   Language:Japanese   Book type:Scholarly book

  • 先天性心疾患

    山村 健一郎, 城尾 邦隆, 中澤 誠(Role:Joint author)

    メジカルビュー社  2014.9 

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    Responsible for pages:「ファロー四徴」「ファロー四徴、肺動脈閉鎖、主要体肺側副動脈」「肺動脈弁欠如症候群」   Language:Japanese   Book type:Scholarly book

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Presentations

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MISC

  • 特集 小児循環器のファーストタッチから専門診療へ 「川崎病」

    山村 健一郎

    小児科診療 80(1): 125 -130 2017   2017.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 特集 慢性心疾患児の一生を診る 「Fallot四徴症」

    山村 健一郎

    小児内科 48巻10号, 1467-1470, 東京医学社 2016   2016.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • チアノーゼの全身合併症

    山村 健一郎

    日本成人先天性心疾患学会雑誌 4巻2合 30-35   2015.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • チアノーゼ型先天性心疾患の特徴 心エコーで何を見ればよいのか

    山村 健一郎

    心エコー 17巻2号, 132-137   2015.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Fontan手術後の抗凝固・抗血小板療法 最善の治療法とは?

    山村 健一郎

    日本小児循環器学会雑誌31巻5号238-239   2015.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • 日本小児救急医学会

  • 日本Pediatric Interventional Cardiology学会

  • 日本川崎病学会

  • 九州小児不整脈研究会(世話人)

  • 九州川崎病研究会(世話人)

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Committee Memberships

  • American Heart Association   FAHA  

    2024.3   

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    Committee type:Academic society

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  • Japanese Society of Adult Congenital Heart Disease   Director  

    2024.1   

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    Committee type:Academic society

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  • 30th Annual Meeting of Japanese Society of Pediatric Myocardial Disease   President  

    2021.10   

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    Committee type:Academic society

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  • 日本小児循環器学会   Councilor   Domestic

    2015.8 - Present   

  • 日本小児循環器学会   評議員  

    2015.8   

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Academic Activities

  • 座長(Chairmanship)

    第36回日本川崎病学会総会・学術集会  ( Japan ) 2016.9 - 2016.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第52回日本小児循環器学会総会・学術集会  ( Japan ) 2016.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第22回日本胎児心臓病学会学術集会  ( Japan ) 2016.2

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第18回日本成人先天性心疾患学会  ( Japan ) 2016.1

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第51回日本小児循環器学会総会・学術集会  ( Japan ) 2015.7

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    Type:Competition, symposium, etc. 

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Research Projects

  • Elucidating the Mechanisms and Reversibility of Congestive Hepatic Fibrosis in Right Heart Failure Using Multimodality Approaches

    Grant number:24K11193  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    山村 健一郎, 田中 正剛, 岩崎 健, 坂本 一郎

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    Grant type:Scientific research funding

    肝硬変・肝臓がんの原因としてのうっ血性肝線維化の重要性が増しているが、その可逆性についてはデータがない。申請者らは、Fallot四徴症術後遠隔期に右心不全による肝線維化マーカーの上昇や肝臓がんがみられることを報告した。本研究では、うっ血性肝線維化の肺動脈弁置換術の前後での変化を、MRI T1 mappingや超音波elastogpraphyといった画像診断を用いて評価する。また、同時に肝線維化マーカー計測、肝生検による病理学的評価、心カテやMRIによる血行動態の評価を行うことにより、右心不全改善によるうっ血性肝線維化の可逆性を明らかにし、その予測指標を確立する。

    CiNii Research

  • Quantification of right ventricular fibrosis with cardiac magnetic resonance imaging and dual-energy computed tomography

    Grant number:20K08449  2020 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    山村 健一郎, 坂本 一郎, 山崎 誘三, 孝橋 賢一, 帯刀 英樹, 塩瀬 明

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    Authorship:Principal investigator  Grant type:Scientific research funding

    Fallot四徴症は心内修復術後も肺動脈弁閉鎖不全/狭窄により慢性的な右室負荷が残存し、成人期に右室機能不全、致死性不整脈を生じうる。これに対する肺動脈弁置換術の手術適応は世界的に見ても未だに定まっていない。本研究では、肺動脈弁置換術中の右室心筋生検組織と、MRI高分解能T1 mappingやDual-energy CTといった最新の画像診断技術を用いて、右室心筋線維化の重症度を非侵襲的、定量的に正確に評価する手法を確立する。Fallot四徴症の再手術適応判断はもちろん、肺高血圧症の治療効果判定などにも新たに安全かつ有用な指標を提供し、ガイドライン改訂/患者予後改善に寄与することを目指す。

    CiNii Research

  • CINCA症候群における動脈硬化の生理学的・生化学的バイオマーカーによる解析

    Grant number:24791072  2012 - 2013

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 川崎病類似NLRリガンド誘発冠動脈炎モデルの病態の検討

    2012 - 2013

    Grants-in-Aid for Scientific Research  母子健康教会 小児医学研究助成

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

Class subject

  • 循環器

    2016.10 - 2017.3   Second semester

  • 循環器

    2015.10 - 2016.3   Second semester

  • 循環器

    2014.10 - 2015.3   Second semester

  • 循環器

    2013.10 - 2014.3   Second semester

  • 循環器

    2012.10 - 2013.3   Second semester

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FD Participation

  • 2014.7   Role:Participation   Title:新GPA制度実施にむけたFD

    Organizer:University-wide

Outline of Social Contribution and International Cooperation activities

  • 福岡市学校心臓検診委員(2009.4.1~)
    福岡県学校心臓検診委員(2013.4.1~)
    九州学校保健学会事務局(2011.4.1~2013.3.31)

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Pediatrics

    小児循環器、成人先天性心疾患

Clinician qualification

  • Specialist

    Japan Pediatric Society

  • Specialist

    The Japanese Circulation Society(JCS)

  • Specialist

    日本小児循環器学会

Year of medical license acquisition

  • 2001

Notable Clinical Activities

  • 2009年 九州大学病院ハートセンター成人先天性心疾患外来開設