Updated on 2024/12/05

Information

 

写真a

 
NAGATOMO YUSAKU
 
Organization
Kyushu University Hospital Comprehensive Maternity and Perinatal Care Center Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425421
External link

Degree

  • Doctor of Philosophy

Research Interests・Research Keywords

  • Research theme:Frequent PVC subtly impaired left ventricular function in healthy children

    Keyword:PVC, Cardiomyopathy

    Research period: 2024.5 - 2019.5

  • Research theme:Optimal size selection of ADO device considering the distensibility of PDA

    Keyword:ADO、PDA

    Research period: 2022.5 - 2024.5

  • Research theme:Pituitary function in Fontan patients

    Keyword:Pituitary function, Fontan

    Research period: 2017.4 - 2022.7

Awards

  • JCIC賞

    2023.1   JCIC学会   BandingしたCovered stentでMAPCAの血流制御を行った乳児例

  • JCIC賞

    2022.1   JCIC学会   逆方向中隔穿刺およびWire atrial septostomyによるASD拡大術

Papers

  • Comparison between transcatheter versus surgical intervention for pediatric aortic valvular stenosis: a multicenter study in Japan(タイトル和訳中)

    Muneuchi Jun, Kuraoka Ayako, Nagatomo Yusaku, Yatsunami Koichi, Sagawa Koichi, Yamamura Kenichiro, Nagata Hazumu, Sugitani Yuichiro, Watanabe Mamie

    Heart and Vessels   39 ( 9 )   826 - 836   2024.9   ISSN:0910-8327

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    Language:English   Publisher:シュプリンガー・ジャパン(株)  

  • Comparison between transcatheter versus surgical intervention for pediatric aortic valvular stenosis: a multicenter study in Japan

    Muneuchi, J; Kuraoka, A; Nagatomo, Y; Yatsunami, K; Sagawa, K; Yamamura, K; Nagata, H; Sugitani, Y; Watanabe, M

    HEART AND VESSELS   39 ( 9 )   826 - 836   2024.9   ISSN:0910-8327 eISSN:1615-2573

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    Language:English   Publisher:Heart and Vessels  

    It is controversial whether children with isolated aortic valvular stenosis (vAS) initially undergo transcatheter or surgical aortic valvuloplasty (BAV or SAV). This multicenter retrospective case–control study aimed to explore outcomes after BAV or SAV for pediatric vAS. We studied children (aged < 15 years) with vAS treated at 4 tertiary congenital heart centers, and compared the rates of survival, reintervention, and valve replacement between patients with BAV and SAV. A total of 73 subjects (BAV: N = 52, SAV: N = 21) were studied. Age and aortic annulus z-score at the first presentation were 85 (26–530) days and − 0.45 (− 1.51–0.59), respectively. During the follow-up period of 121 (47–185) months, rates of 10-year survival (BAV: 88% vs. SAV: 92%, P = 0.477), reintervention (BAV: 58% vs. SAV: 31%, P = 0.626), and prosthetic/autograft valve replacement (BAV: 21% vs. SAV: 19%, P = 0.563) did not differ between the groups. Freedom from reintervention rate significantly correlated with aortic annulus z-score (hazard ratio [HR] 0.66, 95% confidence interval [CI] 0.49–0.88, P = 0.005), and freedom from prosthetic/autograft valve replacement rate significantly correlated to the degree of aortic regurgitation after the first intervention (HR: 4.58, 95% CI 1.19–17.71, P = 0.027). Propensity score-matched analysis (N = 16) did not show the differences in survival and reintervention rates between the groups. Long-term survival was acceptable, and the rates of freedom from reintervention and prosthetic/autograft valve replacement were comparable between children with vAS who underwent BAV and SAV.

    DOI: 10.1007/s00380-024-02403-8

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  • The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome

    Nakashima, K; Imai, T; Shiraishi, A; Unose, R; Goto, H; Nagatomo, Y; Kojima-Ishii, K; Mushimoto, Y; Nishiyama, K; Yamamura, K; Nagata, H; Ishimura, M; Kusuhara, K; Koga, Y; Sakai, Y; Ohga, S

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   217 ( 3 )   291 - 299   2024.6   ISSN:0009-9104 eISSN:1365-2249

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    Language:English   Publisher:Clinical and Experimental Immunology  

    The clinical spectrum of Down syndrome (DS) ranges from congenital malformations to premature aging and early-onset senescence. Excessive immunoreactivity and oxidative stress are thought to accelerate the pace of aging in DS patients; however, the immunological profile remains elusive. We investigated whether peripheral blood monocyte-derived dendritic cells (MoDCs) in DS patients respond to lipopolysaccharide (LPS) distinctly from non-DS control MoDCs. Eighteen DS patients (age 2–47 years, 12 males) and 22 controls (age 4–40 years, 15 males) were enrolled. CD14-positive monocytes were immunopurified and cultured for 7 days in the presence of granulocyte-macrophage colony-stimulating factor and IL-4, yielding MoDCs in vitro. After the LPS-stimulation for 48 hours from days 7 to 9, culture supernatant cytokines were measured by multiplex cytokine bead assays, and bulk-prepared RNA from the cells was used for transcriptomic analyses. MoDCs from DS patients produced cytokines/chemokines (IL-6, IL-8, TNF-α, MCP-1, and IP-10) at significantly higher levels than those from controls in response to LPS. RNA sequencing revealed that DS-derived MoDCs differentially expressed 137 genes (74 upregulated and 63 downregulated) compared with controls. A gene enrichment analysis identified 5 genes associated with Toll-like receptor signaling (KEGG: hsa04620, P = 0.00731) and oxidative phosphorylation (hsa00190, P = 0.0173) pathways. MoDCs obtained from DS patients showed higher cytokine or chemokine responses to LPS than did control MoDCs. Gene expression profiles suggest that hyperactive Toll-like receptor and mitochondrial oxidative phosphorylation pathways configure the immunoreactive signature of MoDCs in DS patients.

    DOI: 10.1093/cei/uxae048

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  • Extracorporeal membrane oxygenation support for balloon atrial septostomy in a BMPR2 variant-associated pulmonary arterial hypertension

    Fukuoka, S; Kaku, N; Nagata, H; Nagatomo, Y; Higashi, K; Toyomura, D; Hirata, Y; Hirono, K; Yamamura, K; Ohga, S

    PEDIATRIC PULMONOLOGY   59 ( 6 )   1789 - 1791   2024.6   ISSN:8755-6863 eISSN:1099-0496

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    Language:English   Publisher:Pediatric Pulmonology  

    DOI: 10.1002/ppul.26973

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  • カテーテルマッピングとアブレーションが奏効した小児発症非リエントリー性束枝頻拍の1例(Successful mapping and ablation of a pediatric-onset non-reentrant fascicular tachycardia)

    Nagatomo Yusaku, Takase Susumu, Sakamoto Kazuo, Nagata Hazumu, Yamamura Kenichiro, Tsutsui Hiroyuki, Ohga Shouichi

    Journal of Cardiology Cases   29 ( 4 )   165 - 169   2024.4

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    Language:English   Publisher:(一社)日本心臓病学会  

    症例は10歳男児。労作時の失神やめまいを主訴に紹介受診した。症状は6歳頃より出現し、9歳以降頻度が増えていたが、激しい運動は控えていた。10歳時に心室頻拍(VT)が初めて記録され、アデノシン三リン酸、リドカインの投与後もVTは抑制されなかった。ベラパミル5mgの静注後、VTはわずかに減速した。プロプラノロール経口投与ではVTが抑制されなかったため、CARTO3マッピングシステムによるガイド下で高周波カテーテルアブレーションを行った。詳細なVTマッピングにより、左室中隔の左後筋膜に最も早い収縮期前のプルキンエ電位が存在することが判明した。この部位に高周波電流を流し、高用量イソプロテレノールと心室バーストペーシングによって非誘発性となった。その後、抗不整脈薬や運動制限なしで、2年間にわたり頻拍の再発は認められていない。

  • Successful mapping and ablation of a pediatric-onset non-reentrant fascicular tachycardia

    Nagatomo Y., Takase S., Sakamoto K., Nagata H., Yamamura K., Tsutsui H., Ohga S.

    Journal of Cardiology Cases   29 ( 4 )   165 - 169   2024.4

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    Language:English   Publisher:Journal of Cardiology Cases  

    Non-reentrant fascicular tachycardia (NRFT) developed in a 6-year-old Japanese boy. Because of drug-resistant recurrences, he received catheter mapping and ablation at age 10 years. An electrocardiogram exhibited a superior left-axis deviation, a right bundle branch block-type configuration, and relatively narrow QRS with sharp R wave. It suggested verapamil-sensitive ventricular tachycardia (VT), but showed no sensitivity to verapamil or reentrant characteristics in the electrophysiological study. Detailed VT mapping determined the earliest presystolic Purkinje potential on the left posterior fascicle at the mid-ventricular septum. Radiofrequency current applications to the lesion led to his NRFT-free life without restriction. Learning objectives: Purkinje-related idiopathic ventricular tachycardias (VTs) are commonly due to reentrant mechanisms, and non-reentrant fascicular tachycardia (NRFT) is a rare form of idiopathic VT in adults. Although it is crucial to distinguish NRFT from reentrant VTs, there is no information about the electrophysiological studies and the treatment effect in pediatric-onset NRFT.

    DOI: 10.1016/j.jccase.2023.12.002

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  • Nationwide registry data of catheter interventions and ablations for congenital heart disease, Kawasaki disease, and tachyarrhythmias in Japan during 2020

    Kise Hiroaki, Kim Sung-Hae, Matsui Hikoro, Inuzuka Ryo, Yoshimoto Jun, Aoki Hisaaki, Kato Atsuko, Fujimoto Kazuto, Ibuki Keijiro, Kondo Maiko, Nagatomo Yusaku, Kumamaru Hiraku, Miyata Hiroaki, Hara Hidehiko, Suda Kenji, Nishikawa Hiroshi, Sugiyama Hisashi, Tomita Hideshi, Yazaki Satoshi, Kobayashi Toshiki, Otsuki Shinichi

    Journal of JPIC   8 ( 2 )   25 - 34   2024.1   eISSN:24322342

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    Language:Japanese   Publisher:Japanese Society of Pediatric Interventional Cardiology  

    The Japanese Society of Congenital Interventional Cardiology (JCIC) had conducted the annual questionnaire surveillance regarding catheter-based interventional procedures and adverse events since 1993. The internet registry system named JCIC-Registry (JCIC-R) went into operation with the initial enrollment of the actual cases since January 2013. In this report, we demonstrate annual 4,554 catheter-based therapeutic sessions during 2020, the fifth year after complete transition to online registration. The JCIC-R maintains specific feature of the nationwide comprehensive real-world registry involving any types of interventions and ablations for congenital heart disease, cardiovascular sequelae following Kawasaki disease, and tachyarrhythmias. In 2020, the audit started to ensure the quality and the completion of registry data, and the JCIC-R is becoming more reliable. In addition to benchmarking and multi-institutional research, we effectively utilize the registry in various fields, such as new device development with post-marketing surveillance, application, and approval process.

    DOI: 10.20599/jjcic.8.25

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  • Coil Embolization in Pediatric Cardiology: Tailored Treatment for Vascular Anatomy

    Nagatomo Yusaku

    Pediatric Cardiology and Cardiac Surgery   39 ( 4 )   217 - 226   2023.12   ISSN:09111794 eISSN:21872988

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    Language:Japanese   Publisher:Japanese Society of Pediatric Cardiology and Cardiac Surgery  

    <p>Vascular embolization, specifically coil embolization, is performed widely in pediatric cardiology. Indications for embolization have been increasing because of the development of devices in recent years. Provided the necessity to embolize diverse anatomic vessels in congenital heart disease, it is crtitical to carefully consider the risks and precautions associated with each vascular anatomy when developing a treatment strategy. This article describes the basic techniques and special considerations for vascular anatomy embolization that include our own approaches.</p>

    DOI: 10.9794/jspccs.39.217

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  • Long-Term Renal Involvement in Association with Fontan Circulation

    Muraoka, M; Nagata, H; Yamamura, K; Sakamoto, I; Ishikita, A; Nishizaki, A; Eguchi, Y; Fukuoka, S; Uike, K; Nagatomo, Y; Hirata, Y; Nishiyama, K; Tsutsui, H; Ohga, S

    PEDIATRIC CARDIOLOGY   45 ( 2 )   340 - 350   2023.11   ISSN:0172-0643 eISSN:1432-1971

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    Language:English   Publisher:Pediatric Cardiology  

    Multiorgan dysfunction is a concern of Fontan patients. To clarify the pathophysiology of Fontan nephropathy, we characterize renal disease in the long-term observational study. Medical records of 128 consecutive Fontan patients [median age: 22 (range 15–37) years old] treated between 2009 and 2018 were reviewed to investigate the incidence of nephropathy and its association with other clinical variables. Thirty-seven patients (29%) showed proteinuria (n = 34) or < 90 mL/min/1.73 m2 of estimated glomerular filtration rate (eGFR) (n = 7), including 4 overlapping cases. Ninety-six patients (75%) had liver dysfunction (Forns index > 4.21). Patients with proteinuria received the Fontan procedure at an older age [78 (26–194) vs. 56 (8–292) months old, p = 0.02] and had a higher cardiac index [3.11 (1.49–6.35) vs. 2.71 (1.40–4.95) L/min/m2, p = 0.02], central venous pressure [12 (7–19) vs. 9 (5–19) mmHg, p < 0.001], and proportion with > 4.21 of Forns index (88% vs. 70%, p = 0.04) than those without proteinuria. The mean renal perfusion pressure was lower in patients with a reduced eGFR than those without it [55 (44–65) vs. 65 (45–102) mmHg, p = 0.03], but no other variables differed significantly. A multivariable analysis revealed that proteinuria was associated with an increased cardiac index (unit odds ratio 2.02, 95% confidence interval 1.12–3.65, p = 0.02). Seven patients with severe proteinuria had a lower oxygen saturation than those with no or mild proteinuria (p = 0.01, 0.03). Proteinuria or a decreased eGFR differentially occurred in approximately 30% of Fontan patients. Suboptimal Fontan circulation may contribute to the development of proteinuria and reduced eGFR.

    DOI: 10.1007/s00246-023-03334-3

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  • Vasospastic angina in a boy with hereditary hemorrhagic telangiectasia due to heterogenous large deletion around <i>ENG</i>

    Narazaki, K; Nagatomo, Y; Uike, K; Sonoda, M; Nagata, H; Yamamura, K; Ohga, S

    PEDIATRICS INTERNATIONAL   65 ( 1 )   e15500   2023.1   ISSN:1328-8067 eISSN:1442-200X

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    Language:English   Publisher:Pediatrics International  

    DOI: 10.1111/ped.15500

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  • Paradoxical spells during ACTH treatment in an infant with Tetralogy of Fallot

    Kikuno, R; Yamamura, K; Nagatomo, Y; Nagata, H; Ichimiya, Y; Sakai, Y; Ohga, S

    PEDIATRICS INTERNATIONAL   65 ( 1 )   e15503   2023.1   ISSN:1328-8067 eISSN:1442-200X

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    Language:English   Publisher:Pediatrics International  

    DOI: 10.1111/ped.15503

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  • 九州・山口地区における小児心臓移植の現状と課題

    平田 悠一郎, 小林 優, 豊村 大亮, 寺師 英子, 長友 雄作, 永田 弾, 賀来 典之, 篠原 玄, 安東 勇介, 塩瀬 明, 大賀 正一

    移植   58 ( Supplement )   s196_2 - s196_2   2023   ISSN:05787947 eISSN:21880034

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    Language:Japanese   Publisher:一般社団法人 日本移植学会  

    <p>【背景】当院は2020年5月に大阪以西で唯一の小児心臓移植実施施設に認定された。それ以前は九州・山口地区で心移植を希望する小児重症心不全患者は遠方の医療施設に頼らなければならず、治療の選択が狭められることもあった。当院の小児心臓移植を中心とした重症心不全診療の現状と課題を考察する。【現状】機械的循環補助や心移植を考慮する症例は、毎年5例程度の診療依頼がある。うち2020年以降に新たに心臓移植登録したのは拡張型心筋症4例、先天性心疾患1例で、4例が登録時11歳未満であった。人口およそ1400万人の九州・山口地区で年1-2例の小児心臓移植適応患者が発生することとなる。3例が補助人工心臓を装着して待機し、2022年9月に11歳未満の小児第1例目の心臓移植を実施した。【課題】小児ドナー不足はコロナ禍で拍車がかかり、当院の移植待機患者は最長で4年目となった。待機が長期化するほど感染や血栓など合併症のリスクは増加し、患者や家族の精神的負担も大きな問題となる。また長期入院は病棟運営にも少なからず影響する。【解決に向けて】ドナーを増やす努力が解決への鍵となるが、年々移植医療に対する医療者および市民の意識は高まってきている。また九州・山口地区は地域間の繋がりも強く、情報を共有し地区全体で重症児を支える意識を持てば、より良い小児重症心不全診療に繋がる。</p>

    DOI: 10.11386/jst.58.supplement_s196_2

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  • Fallot四徴症でACTH治療中に奇異性の発作がみられた乳児例(Paradoxical spells during ACTH treatment in an infant with Tetralogy of Fallot)

    Kikuno Rie, Yamamura Kenichiro, Nagatomo Yusaku, Nagata Hazumu, Ichimiya Yuko, Sakai Yasunari, Ohga Shouichi

    Pediatrics International   65 ( 1 )   1 of 3 - 3 of 3   2023   ISSN:1328-8067

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    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

    症例は9ヵ月齢男児。Down症候群とFallot四徴症に罹患していた。右室流出路閉塞は比較的軽症であり、出生以降、チアノーゼまたは無酸素発作のエピソードはみられていなかった。9ヵ月齢になってから点頭発作を伴う強直性攣縮がみられ始めた。脳波検査でヒプスアリスミアが示されたことからWest症候群と確定診断され、副腎皮質刺激ホルモン(ACTH)治療を行うため当院へ入院となった。入院6日目にACTH治療を開始したが、同治療6日目の哺乳後に徐脈(心拍数60bpm)とチアノーゼを発症した。心エコー法では右室流出路閉塞の悪化と肺血流量の減少が示された。無酸素発作を疑い、体位をchest-knee positionとしたところ、容量輸液を行わずとも約30分後に発作は回復した。以降も徐脈がみられ無酸素発作を間欠的に4回発症したことからACTH治療は中止した。その中止から2日後の心拍数は110bpmまで回復し、無酸素発作はもはやみられなくなっていた。ACTH中止後はトピラマートを使用した。以降も無酸素発作または攣縮発作はみられず退院した。14ヵ月齢時に心内修復術が施行され、術後経過に問題はみられず、6ヵ月間の経過観察中にもてんかん性攣縮は再発しなかった。

  • ENG遺伝子周辺のヘテロ接合型大規模欠失に起因していた遺伝性出血性毛細血管拡張症の男児に発症した血管攣縮性狭心症(Vasospastic angina in a boy with hereditary hemorrhagic telangiectasia due to heterogenous large deletion around ENG)

    Narazaki Kentaro, Nagatomo Yusaku, Uike Kiyoshi, Sonoda Motoshi, Nagata Hazumu, Yamamura Kenichiro, Ohga Shouichi

    Pediatrics International   65 ( 1 )   1 of 3 - 3 of 3   2023   ISSN:1328-8067

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    症例は13歳男児。夜間に強い胸痛が出現し、当院へ緊急入院となった。心電図ではST上昇が、血液検査では血清心筋トロポニンI濃度の高値が示された。血管造影中のアセチルコリン誘発試験では冠動脈攣縮の証拠が確かめられた。経皮的酸素飽和度は93%と軽症の低酸素血症が示された。造影CTでは両肺野に多発する肺動静脈奇形が描出された。履歴を聴取したところ、患児は幼い頃から鼻出血を繰り返しており、また父には皮膚動静脈奇形の家族歴があることが判明した。低酸素血症を改善させるため、全ての肺動静脈奇形に対し、Amplatzerバスキュラープラグとマイクロコイルを用いた経皮的塞栓術を施行した。塞栓術後、安静にしている状態で狭心症の症状が再発した。しかしその後はカルシウム遮断薬のベラパミル50mg/日を予防的に投与することで狭心症の症状は完全に制御された。遺伝性出血性毛細血管拡張症の4大基準のうち2つ(肺動静脈奇形と再発性鼻出血)がみられたことから分子遺伝学的検査を実施した。その結果、ENG遺伝子と他7つの遺伝子を含む、200000塩基を超えるヘテロ接合型大規模欠失が認められた。

  • Clinical outcomes of pulmonary agenesis: A systematic review of the literature

    Fukuoka, S; Yamamura, K; Nagata, H; Toyomura, D; Nagatomo, Y; Eguchi, Y; Uike, K; Hirata, Y; Inoue, H; Ochiai, M; Ohga, S

    PEDIATRIC PULMONOLOGY   57 ( 12 )   3060 - 3068   2022.12   ISSN:8755-6863 eISSN:1099-0496

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    Language:English   Publisher:Pediatric Pulmonology  

    Introduction: Pulmonary agenesis is a complete absence of the pulmonary parenchyma, airways, and vasculature unilaterally or bilaterally. Although bilateral cases are lethal, the outcome of unilateral cases remains not well described. We performed a comprehensive literature review to assess the clinical features of pulmonary agenesis. Methods: Four database sources were searched on October 10, 2021 and two cases were included from our institution. Studies related to the clinical impact of comorbidity and intervention on the survival outcome in pulmonary agenesis were included for full-text review. Results: We identified 259 patients—with right-sided (59%), left-sided (34%), and bilateral agenesis (7%)—among 195 articles and our two cases. Additional anomalies included cardiovascular (40%), skeletal (30%), gastrointestinal (20%), tracheal (20%: all stenoses), and genitourinary (14%) anomalies. Fifty-seven (24%) individuals in unilateral pulmonary agenesis had isolated disease. Outcomes related to survival were not uniformly reported, but the 2-year overall survival rate of unilateral agenesis was 62% and no subsequent death was reported until 13 years of age. The right-sided agenesis was more frequently associated with tracheal stenosis (27% vs. 11%, p = 0.003) than the left-sided disease. A multivariable analysis indicated that tracheal stenosis (hazard ratio [HR]: 2.2, 95% confidence interval [CI]: 1.3–4.1, p = 0.003) and gastrointestinal anomalies (HR: 2.0, 95% CI: 1.1–3.3, p = 0.010) were prognostic factors for mortality. Conclusions: The poor prognostic factors were tracheal stenosis, right agenesis, and gastrointestinal anomalies. Treatment for these comorbidities is a key point for improving the survival of unilateral pulmonary agenesis.

    DOI: 10.1002/ppul.26135

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  • Congenital portosystemic venous shunt associated with 22q11.2 deletion syndrome: a case report

    Ifuku, T; Suzuki, S; Nagatomo, Y; Yokoyama, R; Yamamura, Y; Nakatani, K

    BMC PEDIATRICS   22 ( 1 )   379   2022.6   eISSN:1471-2431

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    Language:English   Publisher:BMC Pediatrics  

    Background: 22q11.2 deletion syndrome (22qDS) is the most common chromosomal microdeletion syndrome and is associated with a high rate of congenital heart disease (CHD) and neurodevelopmental abnormalities. Congenital portosystemic venous shunts (CPSS) are rare developmental abnormalities of the portal venous system. The clinical manifestations of CPSS are varied, and some patients have CHD or genetic chromosomal abnormalities, but their relationship remains unknown. We report the first case of CPSS associated with 22qDS. Case presentation: A newborn boy referred to our institution was diagnosed with 22qDS due to characteristic facial features and complications of tetralogy of Fallot. A subsequent newborn screening test indicated hypergalactosemia and high blood levels of ammonia and bile acids. Upon closer examination, these abnormalities were found to be caused by the CPSS. Abdominal contrast-enhanced computed tomography and angiography confirmed that abnormal blood vessels ascended from the splenic vein and short-circuited to the left renal vein. Intracardiac repair for CHD was performed at 1 year of age, followed by transcatheter occlusion of the CPSS using a multilayer device (vascular plug) and detachable coil at 2 years of age. After treatment, the abnormal blood parameters promptly normalized. Conclusions: As the blood flow of CPSS bypasses the liver, the levels of galactose, bile acids, and ammonia in the systemic veins can increase. Some patients with CPSS have CHD, and these toxic substances may cause liver and lung lesions as well as portosystemic encephalopathy (PSE). Several genetic chromosomal abnormalities, including 22qDS, and CPSS have similar symptoms, and neurodevelopmental abnormalities, particularly those caused by PSE, may be difficult to diagnose. Blood tests, such as newborn screening, and abdominal imaging are useful in the early diagnosis of CPSS.

    DOI: 10.1186/s12887-022-03447-3

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    PubMed

  • Nationwide registry data of catheter interventions and ablations for congenital heart disease, Kawasaki disease, and tachyarrhythmias in Japan during 2019

    Kim Sung-Hae, Matsui Hikoro, Inuzuka Ryo, Yoshimoto Jun, Aoki Hisaaki, Kato Atsuko, Fujimoto Kazuto, Ibuki Keijiro, Kise Hiroaki, Kondo Maiko, Nagatomo Yusaku, Kumamaru Hiraku, Miyata Hiroaki, Hara Hidehiko, Suda Kenji, Nishikawa Hiroshi, Sugiyama Hisashi, Tomita Hideshi, Yazaki Satoshi, Kobayashi Toshiki, Otsuki Shinichi

    Journal of JPIC   6 ( 2 )   17 - 28   2022.4   eISSN:24322342

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    Language:Japanese   Publisher:Japanese Society of Pediatric Interventional Cardiology  

    The Japanese Society of Congenital Interventional Cardiology (JCIC) had conducted the annual questionnaire surveillance regarding catheter-based interventional procedures and adverse events since 1993. The internet registry system named JCIC-Registry (JCIC-R) went into operation with the initial enrollment of the actual cases since January 2013. In this report, we demonstrate annual 4,805 catheter-based therapeutic sessions during 2019, the fourth year after complete transition to online registration. The JCIC-R maintains specific feature of the nationwide comprehensive real-world registry involving any types of interventions and ablations for congenital heart disease, cardiovascular sequelae following Kawasaki disease, and tachyarrhythmias. In addition to benchmarking and multi-institutional research, we effectively utilize the registry in various fields, such as new device development with post-marketing surveillance, application and approval process.

    DOI: 10.20599/jjcic.6.17

    CiNii Research

  • Percutaneous coil embolization and stent implantation for multiple coronary-to-pulmonary artery fistulas with giant coronary aneurysms: a case report

    Nakano, Y; Matoba, T; Nagatomo, Y; Tsutsui, H

    EUROPEAN HEART JOURNAL-CASE REPORTS   6 ( 3 )   ytac104   2022.3   eISSN:2514-2119

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    Language:English   Publisher:European Heart Journal - Case Reports  

    Background: Multiple coronary-to-pulmonary artery fistulas (CPAFs) with giant coronary aneurysms (CAs) are extremely rare. The appropriate therapeutic indication and strategy for CPAFs have not been established. Case summary: Herein, we report the case of an asymptomatic 74-year-old woman with multiple CPAFs associated with giant CAs that had gradually developed over a 4-year period. After heart team discussion, we were successfully treated by minimally invasive intervention using transcatheter coil embolization and coronary stent implantation to prevent ruptures. Discussion: Coronary-to-pulmonary artery fistulas required evaluation of the appropriate timing of therapy initiation with reference to the presence of symptoms and fistula and aneurysm sizes, and determination of the optimal therapeutic approach with reference to the anatomy of the fistula with aneurysm and patient background characteristics.

    DOI: 10.1093/ehjcr/ytac104

    Web of Science

    Scopus

    PubMed

  • 先天性僧帽弁後尖裂隙の7症例

    林 綾子, 長友 雄作, 河原 吾郎, 神谷 登紀子, 佐藤 翼, 花田 麻美, 福留 裕八, 豊村 大亮, 坂本 一郎

    超音波検査技術抄録集   47 ( 0 )   S186 - S186   2022

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    Language:Japanese   Publisher:一般社団法人 日本超音波検査学会  

    DOI: 10.11272/jssabst.47.0_s186_1

    CiNii Research

  • Effective infliximab therapy for the early regression of coronary artery aneurysm in Kawasaki disease Invited Reviewed International journal

    Nagatomo Y, Muneuchi J, Nakashima Y, Nanishi E, Shirozu H, Watanabe M, Uike K, Nagata H, Hirata Y, Yamamura K, Takahashi Y, Okada S, Suzuki Y, Hasegawa S, Ohga S.

    INTERNATIONAL JOURNAL OF CARDIOLOGY   271   317 - 321   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2018.04.062

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Presentations

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MISC

  • 2020年における先天性心疾患,川崎病および頻拍性不整脈に対するカテーテルインターベンション・アブレーション全国集計 日本先天性心疾患インターベンション学会レジストリー(JCIC-Registry)からの年次報告

    喜瀬 広亮, 金 成海, 松井 彦郎, 犬塚 亮, 芳本 潤, 青木 寿明, 加藤 温子, 藤本 一途, 伊吹 圭二郎, 近藤 麻衣子, 長友 雄作, 隈丸 拓, 宮田 裕章, 原 英彦, 須田 憲治, 西川 浩, 杉山 央, 富田 英, 矢崎 諭, 小林 俊樹, 大月 審一, 日本先天性心疾患インターベンション学会(JCIC学会)調査委員会JCICレジストリーワーキンググループ

    Journal of JCIC   8 ( 2 )   25 - 34   2024.1

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    Language:Japanese   Publisher:(一社)日本先天性心疾患インターベンション学会  

    一般社団法人日本先天性心疾患インターベンション学会(JCIC学会)では,カテーテル治療の手技・件数・有害事象に関して,1993年からの全国アンケート集計が開始され,2013年からは日本先天性心疾患インターベンション学会レジストリー(JCIC-R)として全国の小児循環器施設が参加しデータ登録の運用を開始している.本稿では,2020年の1年間における4,554セッションの集計について報告する.本レジストリーは,小児期から成人期にかけての先天性心疾患のみならず,川崎病心血管後遺症や,正常心構造を含む小児期頻拍性不整脈に対するアブレーションを登録対象とし,あらゆるカテーテル治療手技と有害事象を含めるという,日本国内における包括的リアルワールドデータである.2020年からは入力内容に対するauditが開始され,レジストリーデータの質と悉皆登録の担保が図られるようになり,より信頼性の高いレジストリーへと成長している.現在,本レジストリーを利用したデータ利用研究,市販後調査を中心とする新規医療機器導入事業,申請と承認事業で有効活用が行われており,今後,先天性心疾患をはじめとしたカテーテル治療のベンチマーキング,多施設共同研究等,多方面で有効活用が期待される.(著者抄録)

  • 小児循環器領域におけるコイル塞栓術:血管解剖に合わせた塞栓術 Reviewed

    長友雄作

    2023.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 小児循環器領域におけるコイル塞栓術 血管解剖に合わせた塞栓術

    長友 雄作

    日本小児循環器学会雑誌   39 ( 4 )   217 - 226   2023.12   ISSN:0911-1794

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    Language:Japanese   Publisher:(NPO)日本小児循環器学会  

    小児循環器領域において,コイルを中心とした血管塞栓術は多く行われており,近年のデバイスの開発により適応疾患は拡大してきている.主に先天性心疾患の多種多様な解剖の血管に対応する必要があり,血管解剖ごとにリスクや注意点を考えながら治療戦略を立てるのが重要である.本稿では基本的な手技から注意すべき血管解剖への塞栓方法について当施設の考え方を含めて解説する.(著者抄録)

  • 2019年における先天性心疾患、川崎病および頻拍性不整脈に対するカテーテルインターベンション・アブレーション全国集計 日本先天性心疾患インターベンション学会レジストリー(JCIC-Registry)からの年次報告

    金 成海, 松井 彦郎, 犬塚 亮, 芳本 潤, 青木 寿明, 加藤 温子, 藤本 一途, 伊吹 圭二郎, 喜瀬 広亮, 近藤 麻衣子, 長友 雄作, 隈丸 拓, 宮田 裕章, 原 英彦, 須田 憲治, 西川 浩, 杉山 央, 富田 英, 矢崎 諭, 小林 俊樹, 大月 審一

    Journal of JCIC   6 ( 2 )   17 - 28   2022.4

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    Language:Japanese   Publisher:(一社)日本先天性心疾患インターベンション学会  

    一般社団法人日本先天性心疾患インターベンション学会(JCIC学会)では,カテーテル治療の手技・件数・有害事象に関して,1993年からの全国アンケート集計にはじまり,2013年よりインターネットでの日本先天性心疾患インターベンション学会レジストリー(JCIC-R)の運用を開始している.本稿では,完全オンライン移行4年目の2019年の1年間における4,805セッションの集計について報告する.本レジストリーの特徴として,登録対象が小児期から成人期にかけての先天性心疾患のみならず,川崎病心血管後遺症や,正常心構造を含む小児期頻拍性不整脈に対するアブレーションを含め,あらゆるカテーテル治療手技と有害事象を含めるという,一国家における包括的リアルワールドデータであることが挙げられる.ベンチマーキング,多施設共同研究のみならず,市販後調査を中心とする新規医療機器導入事業,申請と承認事業等,多方面で有効活用が始まっている.(著者抄録)

Professional Memberships

  • 日本小児科学会

  • 日本小児循環器学会

  • JCIC学会

  • 日本成人先天性心疾患学会

  • 日本川崎病学会

  • 日本小児心電学会

  • 日本循環器学会

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Committee Memberships

  • JCIC学会   JCIC幹事   Domestic

    2021.1 - 2030.7   

  • Councilor   Domestic

    2020.6 - 2023.7   

  • JCIC学会   JCIC ワーキンググループ   Domestic

    2020.4 - 2025.7   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in Japanese journals:1

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

    Number of peer-reviewed articles in Japanese journals:1

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

Research Projects

  • Fontan患者における下垂体研究

    2021

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • Pituitary research on Fontan patients

    Grant number:19K17568  2019.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Grant type:Scientific research funding

    CiNii Research

Award for Educational Activities

  • 小児科ベストティーチャー賞

       

Class subject

  • 小児科発達医学分野、川崎病

    2024.4 - 2024.9   First semester

  • 小児科発達医学分野、川崎病

    2023.4 - 2023.9   First semester

  • 小児科発達医学分野、川崎病

    2022.4 - 2022.9   First semester

  • 小児科発達医学分野、川崎病

    2021.4 - 2021.9   First semester

Social Activities

  • 学童心臓検診への協力

    2024

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    学童心臓検診への協力

  • 学童心臓検診への協力

    2023

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    学童心臓検診への協力

  • 学童心臓検診への協力

    2022

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    学童心臓検診への協力

  • 学童心臓検診への協力

    2021

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    学童心臓検診への協力

Travel Abroad

  • 2022.9 - 2022.10

    Staying countory name 1:United Kingdom   Staying institution name 1:Birmingham Children Hospital